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成果論文リスト

本支援による成果を含む論文として支援依頼者から報告があった論文を成果が得られた年度順に並べました。成果論文には「先端モデル動物支援」の課題番号「22H04922」を謝辞に入れることをお願いしていますが、課題番号の記載がない論文も含めています。

2022年度

  1. Tetsuya Sasaki.
    Roles of immune molecules in the formation of the cerebral cortex and their abnormalities in psychiatric disorders.
    DOHad Research 2023;11(2):126-134. DOI:10.51067/dohad.11.2_126
  2. Miyake T., Inoue Y., Shao X., Seta T., Aoki Y., Nguyen Pham K.T., Shichino Y., Sasaki J., Sasaki T., Ikawa M., Yamaguchi Y., Okamura H., Iwasaki S., Doi M.
    Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm.
    Cell Reports 2023;42(3):112157. DOI:10.1016/j.celrep.2023.112157
  3. Takemoto T, Hashimoto R, et al.
    Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.
    Molecular Brain 2023;15:34:126-134. DOI:10.1186/s13041-022-00915-w
  4. Yasuhiro Suzuki, Chihiro Nakamoto, Izumi Watanabe-Iida, Masahiko Watanabe, Tomonori Takeuchi, Toshikuni Sasaoka, Manabu Abe, Kenji Sakimura.
    Quantitative analysis of NMDA receptor subunits proteins in mouse brain.
    Neurochemistry International 2023;165:105517. DOI:10.1016/j.neuint.2023.105517
  5. Hirohito Esaki, Yuki Sasaki, Naoya Nishitani, Hikari Kamada, Satoko Mukai, Yoshitaka Ohshima, Sao Nakada, Xiyan Ni, Satoshi Deyama, Katsuyuki Kaneda.
    Role of 5-HT1A receptors in the basolateral amygdala on 3,4-methylenedioxymethamphetamine-induced prosocial effects in mice.
    European journal of pharmacology 2023;946:175653. DOI:10.1016/j.ejphar.2023.175653
  6. Iguchi K, Sada R, Matsumoto S, Kimura H, Zen Y, Akita M, Gon H, Fukumoto T, Kikuchi A.
    DKK1-CKAP4 signal axis promotes hepatocellular carcinoma aggressiveness.
    Cancer Science 2023;114(5):2063-2077. DOI:10.1111/cas.15743
  7. Kitakaze, M., Hara, T., Hirai, T., Okuzaki, D., Sekido, Y., Hata, T., Ogino, T., Takahashi, H., Miyoshi, N., Ofusa, K., Eguchi, H., Doki, Y., Ishii, H.
    Cancer-specific tissue-resident memory T-cells in colorectal cancer.
    Br J Cancer 2023;128(10):1828-1837. DOI:10.1038/s41416-023-02202-4
  8. Furukawa T, Tabata S, Minami K, Yamamoto M, Kawahara K, Tanimoto A.
    Metabolic reprograming of cancer as a therapeutic target.
    Biochim Biophys Acta Gen Subj 2023;1867(3):130301. DOI:10.1016/j.bbagen.2022.130301
  9. Ueda J, Yamazaki T, Funakoshi H.
    Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges.
    Int J Mol Sci. 2023;24(5):4778. DOI:10.3390/ijms24054778
  10. Pagano R, Salamian A, Zielinski J, ..., Bito H, Muller CP, Schumann G, Okuno H, Radwanska K.
    Arc controls alcohol cue relapse by a central amygdala mechanism.
    Mol Psychiatry 2023;28(2):733-745. DOI:10.1038/s41380-022-01849-4
  11. Chen M, Kumakura N, Saito H, Muller R, Nishimoto M, Mito M, Gan P, Ingolia NT, Shirasu K, Ito T, Shichino Y, and Iwasaki S.
    A parasitic fungus employs mutated eIF4A to survive on rocaglate-synthesizing Aglaia plants.
    eLife 2023;12:e81302. DOI:10.7554/eLife.81302
  12. Toyokuni S, Kong Y, Zheng H, Maeda Y, Katabuchi M, Motooka Y.
    Three-dimensional regulation of ferroptosis at the intersection of iron, sulfur and oxygen executing scrap and build toward evolution.
    Antioxidants and Redox Signaling 2023;Online Ahead of Print. DOI:10.1089/ars.2022.0142
  13. Yoneda T, Hayashi K, Yoshimura Y.
    Experience-dependent functional plasticity and visual response selectivity of surviving subplate neurons in the mouse visual cortex.
    PNAS 2023;120(9):e2217011120. DOI:10.1073/pnas.2217011120
  14. Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Onodera O, Iwakura Y, Nawa H, Komatsu M, Fujii M.
    USP10 inhibits aberrant cytoplasmic aggregation of TDP-43 by promoting stress granule clearance.
    Mol Cell Biol. 2023;42(3):e0039321. DOI:10.1128/MCB.00393-21
  15. Awakawa T, Liu W, Bai T, Taniguchi T, Abe I.
    Orthoester formation in fungal meroterpenoid austalide F biosynthesis.
    Phil. Trans. R. Soc. B 2023;378(1871):20220037. DOI:10.1098/rstb.2022.0037
  16. Yamashita A, Shichino Y, Fujii K, Koshidaka Y, Adachi M, Sasagawa E, Mito M, Nakagawa S, Iwasaki S, Takao K, Shiina N.
    ILF3 prion-like domain regulates gene expression and fear memory under chronic stress.
    iScience 2023;26(3):06229. DOI:10.1016/j.isci.2023.106229
  17. Yasuyo Ohguchi, Hiroto Ohguchi.
    DIS3: The Enigmatic Gene in Multiple Myeloma.
    International Journal of Molecular Sciences 2023;24(4):4079. DOI:10.3390/ijms24044079
  18. Shinji Kishimoto, Ayumi Minami, Yoshimitsu Aoki, Yuya Matsubara, Shogo Watanabe and Kenji Watanabe.
    Reactive Azlactone Intermediate Drives Fungal Secondary Metabolite Cross-Pathway Generation.
    Journal of the American Chemical Society 2023;145(5):3221-3228. DOI:10.1021/jacs.2c13188
  19. Yutaka Kanoh, Masaru Ueno, Motoshi Hayano, Satomi Kudo, Hisao Masai.
    Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect.
    Life Science Alliance 2023;6(4):e202201603 DOI:10.26508/lsa.202201603
  20. Saito H, Osaki T, Ikeuchi Y, and Iwasaki S.
    High-throughput assessment of mitochondrial protein synthesis in mammalian cells using mito-FUNCAT FACS.
    Bio Protoc. 2023;13(3):e4602. DOI:10.21769/BioProtoc.4602
  21. Kyosuke Mukae, Hisanori Takenobu, Yuki Endo, Michinori Funato, Junya Toguchida, Kenji Osafune, Tatsutoshi Nakahata, Hiroaki Kanda, Takehiko Kamijo.
    Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell-derived neural crest cells.
    Cancer Science 2023;114(5):1898-1911. DOI:10.1111/cas.15730
  22. Luo Y, Akatsuka S, Motooka Y, Kong Y, Zheng H, Mashimo T, Imaoka T, Toyokuni S.
    BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile-induced mesothelioma via ferroptosis-resistance.
    Cancer Science 2023;114(4):1423-1436. DOI:10.1111/cas.15705
  23. Masami Ishido.
    Chemical nature of attention deficit hyperactivity disorder (ADHD) - related chemical subfamily.
    Chemosphere 2023;313:137495. DOI:10.1016/j.chemosphere.2022.137495
  24. Chi-Chun Yang, Hisao Masai.
    Claspin is Required for Growth Recovery from Serum Starvation through Regulating the PI3K-PDK1-mTOR Pathway in Mammalian Cells.
    Mol Cell Biol. 2023;43:1-21. DOI:10.1080/10985549.2022.2160598
  25. Ohta S, Misawa A, Thu C, Hirose Y, Matsumoto N, Kawakami Y.
    Melanoma antigens recognized by T cells and their use for immunotherapy.
    Experimental Dermatology 2023;32(3):297-305. DOI:10.1111/exd.14741
  26. Shinji Nakamura, Yasuhiro Nakao, Yinmon Htun, ..., Masaki Ueno, Takashi Kusaka.
    Impact of hydrogen gas inhalation during therapeutic hypothermia on cerebral hemodynamics and oxygenation in the asphyxiated piglet.
    Scientific Report 2023;13:1615. DOI:10.1038/s41598-023-28274-z
  27. Yasuto Takeuchi, Noriko Gotoh.
    Inflammatory cytokines-enriched microenvironment plays key roles for the development of breast cancers.
    Cancer Science 2023;114(5):1792-1799. DOI:10.1111/cas.15734
  28. Shin YH, Im JH, Awakawa T, Abe I, Moore BS, Fenical W, Yoon YJ, Cho JC, Lee SK, Oh KB, Oh DC.
    Genomic and Spectroscopic Signature-Based Discovery of Natural Macrolactams.
    J Am Chem Soc. 2023;145(3):1886-1896. DOI:10.1021/jacs.2c11527
  29. Awakawa T, Mori T, Ushimaru R, Abe I.
    Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis.
    Nat Prod Rep. 2023;40(1):46-61. DOI:10.1039/d2np00014h
  30. Cheung A, Konno K, Imamura Kawasawa Y, Matsui A, Abe M, Sakimura K, Sasaoka T, Uemura T, Watanabe M, and Futai K.
    Neurexins in serotonergic neurons regulate serotonin transmission and complex mouse behaviors.
    eLife 2023;12:e85058. DOI:10.7554/eLife.85058
  31. Kurihara, Y, Kotone M, Nagi M, Shoji, H, Miyakawa, T, and Shirane, M.
    PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain.
    Molecular Brain 2023;16(1):11. DOI:10.1186/s13041-023-01002-4
  32. Kei-ichiro Ishiguro.
    Chapter One - Mechanism of initiation of meiosis in mouse germ cells.
    Current Topics in Developmental Biology 2023;151:1-26. DOI:10.1016/bs.ctdb.2022.04.005
  33. Masanori Fujimoto, Yutaro Ruike, Kazuki Ishiwata, Kumiko Naito, Akiko Ishida, Masaya Koshizaka, Sawako Suzuki, Yuki Shiko, Hisashi Koide, Koutaro Yokote.
    Antihypertensive Effects of Esaxerenone in Older Patients with Primary Aldosteronism.
    International journal of hypertension 2023;6453933. DOI:10.1155/2023/6453933
  34. Toyokuni S, Kong Y, Motooka Y, Akatsuka S.
    Environmental impact on carcinogenesis under BRCA1 haploinsufficiency.
    Genes and Environment 2023;45:2. DOI:10.1186/s41021-023-00258-5
  35. Tran Nguyen Truc L, Matsuda S, Takenouchi A, Tran Thuy Huong Q, Kotani Y, Miyazaki T, Kanda H, Yoshizawa K, Tsukaguchi H.
    Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons.
    Scientific Reports 2023;13:508. DOI:10.1038/s41598-023-27766-2
  36. Moriya M, Kasahara Y, Shimada M, Sakakibara Y, Fujii H, Nagase H, Ide S, Ikeda K, Hall FS, Uhl GR, Sora I.
    Role for µ-opioid receptor in antidepressant effects of ∂-opioid receptor agonist KNT-127.
    Journal of Pharmacological Sciences 2023;15(3):135-141. DOI:10.1016/j.jphs.2022.12.008
  37. Hao-Wen Hsiao, Chi-Chun Yang, Hisao Masai.
    Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses.
    Biomolecules 2023;13:125. DOI:10.3390/biom13010125
  38. 石黒啓一郎
    数分裂プログラムの制御における雌雄性差
    日本内分泌学会雑誌 2023;27:28-32
  39. Kazuhide Miyamoto, Hodaka Hayabuchi, Yukiko Tokifuji, Makoto Ando, Nobuyuki Onishi, Tadashi Okamura, Akihiko Yoshimura, Shunsuke Chikuma.
    A Protein Kinase D Inhibitor Suppresses AKT on T cells and Antagonizes Cancer Immunotherapy by Anti-PD-1.
    International Immunology 2022;34(12):609-619. DOI:10.1093/intimm/dxac035
  40. Miyao S, Saito K, Oshima R, Kawahara K, Nagahama M.
    MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing.,Biochem Biophys Res Commun.
    2022;637:203-209. DOI:10.1016/j.bbrc.2022.11.018
  41. Takashi Nagashima, Suguru Tohyama, Kaori Mikami, Masashi Nagase, Mieko Morishima, Atsushi Kasai, Hitoshi Hashimoto, Ayako M Watabe.
    Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.
    Nature Communications 2022;13:7913. DOI:10.1038/s41467-022-35634-2
  42. 岩崎信太郎、吉田稔
    スプライシング阻害と翻訳制御
    Journal of Japanese Biochemical Society 2022;94(6):819-828. DOI:10.14952/SEIKAGAKU.2022.940819
  43. Nakamura, Y., Yahiro, T., Fukushima, A., Kataoka, N., Hioki, H., Nakamura, K.
    Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling.
    Science Advances 2022;8(51):eadd5463. DOI:10.1126/sciadv.add5463
  44. Yoshimatsu S, Nakajima M, Sonn I, Natsume R, Sakimura K, Nakatsukasa E, Sasaoka T, Nakamura M, Serizawa T, Sato T, Sasaki E, Deng H, Okano H.
    Attempts for deriving extended pluripotent stem cells from common marmoset embryonic stem cells.
    Genes to Cells 2022;28(2):156-169. DOI:10.1111/gtc.13000
  45. Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, .., Sakimura K, .., Komatsu M.
    The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.
    Nature communications 2022;13:7857. DOI:10.1038/s41467-022-35501-0
  46. Ishihara Y, Nakamura K, Nakagawa S, Okamoto Y, Yamamoto M, Furukawa T, Kawahara K.
    Nucleolar Stress Response via Ribosomal Protein L11 Regulates Topoisomerase Inhibitor Sensitivity of P53-Intact Cancers.
    Int J Mol Sci. 2022;23(24):15986. DOI:10.3390/ijms232415986
  47. Yoshizawa T, Sato Y, Sobuz S, Mizumoto T, Tsuyama T, Karim Md, Miyata K, Tasaki M, Yamazaki M, Kariba Y, Braun T, Bober E., Auwerx J, Yamagata K.
    SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice.
    Nature Communications 2022;13:7439. DOI:10.1038/s41467-022-35219-z
  48. Hisao Masai.
    Replicon hypothesis revisited.
    Biochemical and Biophysical Research Communications 2022;633:77-80. DOI:10.1016/j.bbrc.2022.09.060
  49. Saito R, Tada Y, Oikawa D, Sato Y, Seto M, Satoh A, Kume K, Ueki N, Nakashima M, Hayashi S, Toyoshima Y, Tokunaga F, Kawakami H, Kakita A.
    Spinocerebellar ataxia type 17-digenic TBP/STUB1 disease: neuropathologic features of an autopsied patient.
    Acta Neuropathol Commun. 2022;10,:77. DOI:10.1186/s40478-022-01486-6
  50. Daikohara K, Akanuma SI, Kubo Y, Hosoya KI.
    Lipopolysaccharide-Induced Functional Alteration of P-glycoprotein in the Ex Vivo Rat Inner Blood-Retinal Barrier.
    Int. J. Mol. Sci. 2022;23(24):15504. DOI:10.3390/ijms232415504
  51. Li X, Chen HP, Zhou L, Fan J, Awakawa T, Mori T, Ushimaru R, Abe I, Liu JK.
    Cordycicadins A-D, Antifeedant Polyketides from the Entomopathogenic Fungus Cordyceps cicadae JXCH1.
    Org Lett. 2022;24(47):8627-8632. DOI:10.1021/acs.orglett.2c03432
  52. Abe M., Saeki N., Ikeda Y., Ohba S.
    Kruppel-Like Factors in skeletal physiology and pathologies.
    Int J Mol Sci. 2022;23(23):15174. DOI:10.3390/ijms232315174
  53. Rahman SMK, Hussain Z, Morito K, Takahashi N, Sikder MM, Tanaka T, Ohta KI, Ueno M, Takahashi H, Yamamoto T, Murakami M, Uyama T, Ueda N.
    Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A 2 ε in an ex vivo murine model of brain ischemia.
    Biochim. Biophys. Acta Mol. Cell Biol. Lipds 2022;1867(12):159222. DOI:10.1016/j.bbalip.2022.159222
  54. Terada K, Nakamura S, Nakao Y, Fukudome K, Miyagi Y, Onishi T, Kusaka T.
    Cerebral hemoglobin oxygenation in children with congenital heart disease.
    Pediatr Int. 2022;64:e14726. DOI:10.1111/ped.14726
  55. Morishita H, Komatsu M.
    Role of autophagy in liver diseases.
    Current Opinion in Physiology 2022;30:100594. DOI:10.1016/j.cophys.2022.100594
  56. Zhang Doudou, Takashi Shimokawa, Qianqian Guo, Shingo Dan, Yoshio Miki, Shigeaki Sunada.
    Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break.
    Cancer Science 2022;114(3):1108-1117. DOI:10.1111/cas.15659
  57. Sakai D, Tomita H, Maeda A.
    Optogenetic Therapy for Visual Restoration.
    International Journal of Molecular Sciences 2022;23(23):15041. DOI:10.3390/ijms232315041
  58. Tao H, Ushimaru R, Awakawa T, Mori T, Uchiyama M, Abe I.
    Stereoselectivity and Substrate Specificity of the Fe(II)/α Ketoglutarate-Dependent Oxygenase TqaL.
    J Am Chem Soc. 2022;144(47):21512-21520. DOI:10.1021/jacs.2c08116
  59. Matsusaka H, Tao W, Furuya K, Yamada-Kato T, Bai L, Tomita H, Sugano E, Ozaki T, Kiyono T, Fukuda T.
    Comprehensive transcriptome data to identify downstream genes of testosterone signalling in dermal papilla cells.
    Scientific Data 2022;9:731. DOI:10.1038/s41597-022-01846-w
  60. Daisuke Hoshi, Emiri Kita, Yoshiaki Maru, Hiroyuki Kogashi,... , Tetsuo Ushiku , Masashi Fukayama , Makiko Itami , Taketo Yamaguchi, Yoshitaka Hippo.
    Derivation of pancreatic acinar cell carcinoma cell line HS-1 as a patient-derived tumor organoid.
    Cancer Science 2022;114(3):1165-1179. DOI:10.1111/cas.15656
  61. Alexis J Haas, Ceniz Zihni, Susanne M Krug, Riccardo Maraspini, Tetsuhisa Otani, Mikio Furuse, Alf Honigmann, Maria Balda, Karl Matter.
    ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions.
    Cells 2022;11(23):3775. DOI:10.3390/cells11233775
  62. Terayama R, Ishikawa T, Ishiwata K, Sato A, Minamizuka T, Ohno T, Kono S, Yamamoto M, Yokoh H, Nagano H, Koshizaka M, Suzuki S, Koide H, Maezawa Y, Yokote K.
    Correction of Hypercortisolemia with an Improved Cognitive Function and Muscle Mass after Transsphenoidal Surgery in an Older Patient with Cushing's Disease: A Case Report.
    Intern Med. 2022;61(22):3391-3399. DOI:10.2169/internalmedicine.8326-21
  63. Showkat Rashid; Takashi Murakami; Hiroshi Koganezawa; Yusuke Yoshigoe; Shoichi Hosoya; Shinichi Saito.
    Fluorinated [2]rotaxanes with spirofluorene motifs: a non-symmetric distribution of the ring component along the axle component.
    New J. Chem. 2022;47:900-909. DOI:10.1039/D2NJ05021H
  64. Sasazawa Y, Souma S, Furuya N, Miura Y, Kazuno S, Kakuta S, Suzuki A, Hashimoto R, Hirawake-Mogi H, Date Y, Imoto M, Ueno T, ..., Hattori N, Saiki S.
    Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2.
    EMBO J. 2022;41(22):e111476. DOI:10.15252/embj.2022111476
  65. Shimizu T et al.
    Depletion of R270C mutant p53 in osteosarcoma attenuates cell growth but does not prevent invasion and metastasis in vivo.
    Cells 2022;11(22):3614. DOI:10.3390/cells11223614
  66. Mizumoto T, Yoshizawa T, Sato Y, Ito T, Tsuyama T, Satoh A, Araki S, Tsujita K, Tamura M, Oike Y, Yamagata K.
    SIRT7 deficiency protects against aging-associated glucose intolerance and extends lifespan in male mice.
    Cells 2022;11(22):3609. DOI:10.3390/cells11223609
  67. Yoshigoe Y, Hashizume K, Saito S.
    Synthesis and stereochemistry of chiral aza-boraspirobifluorenes with tetrahedral boron-stereogenic centers.
    Dalton Transactions 2022;51(44):17035-17039. DOI:10.1039/D2DT03303H
  68. Sato, H., Hara, T., Tatekawa, S., Sasaki, K., Kobayashi, S., Kitagawa, T., Doki, Y., Eguchi, H., Ogawa, K., Uchida, S., Ishii, H.
    Emerging roles of long noncoding and circular RNAs in pancreatic ductal adenocarcinoma.
    Front. Physiol. 2022;13:1025923. DOI:10.3389/fphys.2022.1025923
  69. Jin M., Matsumoto S., Ayaki T., Takahashi R., Takao T. and Hirotsune S.
    DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers.
    Nature Communications 2022;13(1):6880. DOI:10.1038/s41467-022-34555-4
  70. Chikara Takeuchi, Moe Yokoshi, Shu Kondo, Aoi Shibuya, Kuniaki Saito, Takashi Fukaya, Haruhiko Siomi, Yuka W Iwasaki.
    Mod(mdg4) variants repress telomeric retrotransposon HeT-A by blocking subtelomeric enhancers.
    Nucleic Acids Research 2022;50(20):11580-11599. DOI:10.1093/nar/gkac1034
  71. Ohmori I, Ouchida M, Imai H, Ishida S, Toyokuni S, Mashimo T.
    Thioredoxin deficiency increases oxidative stress and causes bilateral symmetrical degeneration in rat midbrain.
    Neurobiology of Disease 2022;175:105921. DOI:10.1016/j.nbd.2022.105921
  72. Komatsu M.
    p62 bodies: phase separation, NRF2 activation, and selective autophagic degradation.
    IUBMB Life 2022;74(12):1200-1208. DOI:10.1002/iub.2689
  73. Shinozaki Y, Leung A, Koizumi S et al.
    Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy.
    Sci Adv. 2022;8 (44) :eabq1081. DOI:10.1126/sciadv.abq1081
  74. Sekido, T., Yamamoto, K., Yanagita, R. C., Kawamani, Y., Hanaki, Y., Irie, K.
    A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities.
    Bioorganic & Medicinal Chemistry 2022;73:116988. DOI:10.1016/j.bmc.2022.116988
  75. Hayashi T.
    Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation.
    Frontiers in Synaptic Neuroscience 2022;14:921772. DOI:10.3389/fnsyn.2022.921772
  76. 中村加枝, 石井宏憲, 安田正治
    様々な視点から意思決定を考察する 薬理学的な視点から
    月刊精神科 (精神科) 2022;41(4):500-507.
  77. Sato, H., Sasaki, K., Hara, T., Kobayashi, S., Doki, Y., Eguchi, H., Satoh, T., Ishii, H.
    Targeting the regulation of aberrant protein production pathway in gastrointestinal cancer treatment.
    Frontiers in Oncology 2022;12:1018333. DOI:10.3389/fonc.2022.1018333
  78. Aoyama M, Ishikawa K, Nemoto S, Hirano H, Watanabe N, Osada H, Watanabe S, Semba K.
    Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells.
    Journal of Biological Chemistry 2022;298(12):102635. DOI:10.1016/j.jbc.2022.102635
  79. Nakagawa S, Kawahara K*, Okamoto Y*, Kodama Y, Nishikawa T, Kawano Y and Furukawa T.
    Association between Dysfunction of the Nucleolar Stress Response and Multidrug Resistance in Pediatric Acute Lymphoblastic Leukemia.
    Cancers 2022;14(20):5127. DOI:10.3390/cancers14205127
  80. Park SW, Jeon P, Yamasaki A, Lee HE, Choi H, Mun JY, Jun YW, Park JH, Lee SH, Lee SK, Lee YK, Song HK, Lazarou M, Cho DH, Komatsu M, Noda NN, Jang DJ, Lee JA.
    Development of new tools to study membrane-anchored mammalian Atg8 proteins.
    Autophagy 2022;19(5):1424-1443. DOI:10.1080/15548627.2022.2132040
  81. Sato, H., Sasaki, K., Hara, T., Kobayashi, S., di Luccio, E., Hirotsu, T., Doki, Y., Eguchi, H., Satoh, T., Uchida, S., Ishii, H. et al.
    Pancreatic Cancer Research beyond DNA Mutations.
    Biomolecules 2022;12(10):1503. DOI:10.3390/biom12101503
  82. Sakaguchi M, Okagawa S, Okubo Y, Otsuka Y, Fukuda K, Igata M, Kondo T, Sato Y, Yoshizawa T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, Araki E.
    Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.
    Nature Communications 2022;13:6092. DOI:10.1038/s41467-022-33842-4
  83. Molla MR, Shimizu A, Komeno M, Rahman NIA, Soh JEC, Nguyen LKC, Khan MR, Tesega WW, Chen S, Pang X, Tanaka-Okamoto M, Takashima N, Sato A, Suzuki T, Ogita H.
    Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity.
    Commun Biol. 2022;5:1071. DOI:10.1038/s42003-022-04042-z
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    Star Protocols 2022;3(2):101421. DOI:10.1016/j.xpro.2022.101421
  162. Suzuki S, Ruike Y, Ishiwata K, Naito K, Igarashi K, Ishida A, Fujimoto M, Koide H, Horiguchi K, Tatsuno I, Yokote K.
    Clinical Usefulness of the Growth Hormone-Releasing Peptide-2 Test for Hypothalamic-Pituitary Disorder.
    J Endocr Soc. 2022;6(8):bvac088. DOI:10.1210/jendso/bvac088
  163. Nakai S, Tateoka Y, Miyaguchi Y, Takahashi M, Ogita H.
    Associations Between Habitual Dietary Behaviors and Glutamic Acid Levels in Human Milk
    J Hum Lact. 2022;39(2):315-324. DOI:10.1177/08903344221095784
  164. Yun-Wei Xue, Hiroaki Itoh, Shingo Dan, Masayuki Inoue.
    Gramicidin A Accumulates in Mitochondria, Reduces ATP Levels, Induces Mitophagy, and Inhibits Cancer Cell Growth.
    Chemical Science 2022;13(25):7482-7491. DOI:10.1039/D2SC02024F
  165. Yamada A, Toya H, Tanahashi M, Kurihara M, Mito M, Iwasaki S, Kurosaka S, Takumi T, Fox A, Kawamura Y, Miura K, and Nakagawa S.
    Species-specific formation of paraspeckles in intestinal epithelium revealed by characterization of NEAT1 in naked mole-rat.
    RNA 2022;28(8):1128-1143. DOI:10.1261/rna.079135.122
  166. Kazuhiro Sakamoto, Hinata Yamada, Norihiko Kawaguchi, Yoshito Furusawa, Naohiro Saito, Hajime Mushiake.
    Reinforcement Learning Model With Dynamic State Space Tested on Target Search Tasks for Monkeys: Extension to Learning Task Events.
    Frontiers in Computational Neuroscience 2022;16:84604. DOI:10.3389/fncom.2022.784604
  167. Tao H, Mori T, Adachi N, Kawasaki M, Moriya T, Senda T, Abe I, Dickschat JS, Liu T.
    Discovery of non-squalene triterpenes.
    Nature 2022;606(7913):414-419,10. DOI:1038/s41586-022-04773-3
  168. Hieu VN, Thuy LTT, Hai H, Dat NQ, Hoang DV, Hanh NV, Phuong DM, Hoang TH, Sawai H, Shiro Y, Sato-Matsubara M, Oikawa D, Tokunaga F, Yoshizato K, Kawada N.
    Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion.
    Redox Biol 2022;52:102286. DOI:10.1016/j.redox.2022.102286
  169. Arao, Y., Nakayama, M., Tsuji, Y., Hamano, Y., Otsuka, C., Vecchione, A., Ofusa, K., Ishii, H.
    EpisomiR, a new family of miRNAs, and its possible roles in human.
    Biomedicines 2022;10(6):1280. DOI:10.3390/biomedicines10061280
  170. Iori Ohmori, Mamoru Ouchida, Masakazu Shinohara, Kiyoka Kobayashi, Saeko Ishida, Tomoji Mashimo.
    Novel animal model of combined generalized and focal epilepsy.
    Epilepsia 2022;63(7) :e80-e85. DOI:10.1111/epi.17295
  171. Kong Y, Akatsuka S, Motooka Y, Zheng H, Cheng Z, Shiraki Y, Mashimo T, Imaoka T, Toyokuni S.
    BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance.
    Redox Biology 2022;54,102356. DOI:10.1016/j.redox.2022.102356
  172. Morimoto y, Tokumitsu A, ..., Shigeki Ohta.
    TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF).
    Neurochem Res. 2022;47:741–2756. DOI:10.1007/s11064-022-03629-6
  173. Oota-Ishigaki A, Takao K, Yamada D, Sekiguchi M, Itoh M, Koshidata Y, Abe M, Natsume R, ...., Sakimura K, Okuno H, Wada K, Mishima M, Miyakawa T, Hayashi T.
    Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice.
    Neuropsychopharmacology 2022;47:2150-2159. DOI:10.1038/s41386-022-01347-9
  174. Okada N, Ueki C, Shimazaki M, Tsujimoto G, Kohno S, Muranaka H, Yoshikawa K, Takahashi C.
    NFYA promotes the malignant behavior of triple-negative breast cancer through the regulation of lipid metabolism.
    bioRxiv 2022;493660. DOI:10.1101/2022.05.26.493660
  175. Ding WX, Ni HM, Waguri S, Komatsu M.
    Lack of Hepatic Autophagy Promotes Severity of Liver Injury but Not Steatosis.
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    Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation.
    scientific reports 2022;12:8718. DOI:10.1038/s41598-022-12293-3
  177. Asano T, Nakamura H,...Takano H, Yao R,... Doi H, Tanaka F.
    Inhibition of Crmp1 phosphorylation at Ser522 ameliorates motor function and neuronal pathology in amyotrophic lateral sclerosis model mice.
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    Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren's syndrome-like exocrinopathy.
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  179. Kishi S, Fujiwara-Tani R, Honoki H, Sasaki R, Mori S, Ohmori H, Sasaki T, Miyagawa Y, Kawahara I, Kido A, Tanaka Y, Kuniyasu H.
    Oxidized high mobility group B-1 on colorectal cancer via metastasis modification of mesenchymal stem cells.
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    Characterization of Enzymes Catalyzing the Initial Steps of the β-Lactam Tabtoxin Biosynthesis
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    Shape and Rule Information Is Reflected in Different Local Field Potential Frequencies and Different Areas of the Primate Lateral Prefrontal Cortex.
    Frontiers in Behavioral Neuroscience 2022;16:750832. DOI:10.3389/fnbeh.2022.750832
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    Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors.
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    Understanding and Manipulating Assembly Line Biosynthesis by Heterologous Expression in Streptomyces.
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    Regiocontrolled Dimerization of Densely Functionalized 1,6-Dihydropyridines for the Biomimetic Synthesis of a Halicyclamine-type Scaffold by Preventing Disproportionation.
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    Neural signals regulating motor synchronization in the primate deep cerebellar nuclei.
    Nat Commun 2022;13:2504. DOI:10.1038/s41467-022-30246-2
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    Conformational Control of [2]Rotaxane by Hydrogen Bond.
    JOURNAL OF ORGANIC CHEMISTRY 2022;87(9):5744-5759. DOI:10.1021/acs.joc.2c00086
  187. Mori T, Nakashima Y, Chen H, Hoshino S, Mitsuhashi T, Abe I.
    Structure-based redesign of Fe(II)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation.
    Chem Commun. 2022;58(36):5510-5513. DOI:10.1039/d2cc00736c
  188. Hoang DV, Thuy LTT, Hai H, Hieu VN, Kimura K, Oikawa D, ..., Tokunaga F, Kubo S, Ohtani N, Yoshizato K, Kawada N.
    Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species.
    Oncogenesis 2022;11:23. DOI:10.1038/s41389-022-00389-4
  189. Shunske Tomita, Kazuho Inaba, Masashi Sekimoto.
    Tyrphostin AG1024 downregulates aryl hydrocarbon receptor (AhR) expression in an IGF1R and IR-independent manner.
    Toxicology Letters 2022;360:62-70. DOI:10.1016/j.toxlet.2022.02.003
  190. 竹馬俊介
    免疫系における内在性レトロウイルスの役割
    臨床免疫・アレルギー科 2022;77(5):645-650
  191. Naoya Aoki, Chihiro Mori, Toshiyuki Fujita, Shouta Serizawa, Shinji Yamaguchi, Toshiya Matsushima, Koichi J Homma.
    Subtype-selective contribution of muscarinic acetylcholine receptors for filial imprinting in newly-hatched domestic chicks.
    Behavioural brain research 2022;424:113789. DOI:10.1016/j.bbr.2022.113789
  192. Tokunaga F, Ikeda F.
    Linear ubiquitination in immune and neurodegenerative diseases, and beyond.
    Biochem Soc Trans. 2022;50(2):799-811. DOI:10.1042/BST20211078
  193. Sato M, Sato-Yamamoto N, Wakita A, Haraguchi M, Shimonishi M, Okuno H.
    Direct injection of recombinant AAV-containing solution into the oviductal lumen of pregnant mice caused in situ infection of both preimplantation embryos and oviductal epithelium.
    Int J Mol Sci. 2022;23(9):4897. DOI:10.3390/ijms23094897
  194. Ohshiro, T., Asai, A., Konno, M., Ohkawa, M., Komoto, Y., Ofusa, K., Ishii, H., Taniguchi, M.
    Direct observation of DNA alterations induced by a DNA disruptor.
    Science Reports 2022;12:6945. DOI:10.1038/s41598-022-10725-8
  195. Hanna M Ciesielski, Hiroshi Nishida, Tomomi Takano, Aya Fukuhara, Tetsuhisa Otani, Yuko Ikegawa, Morihiro Okada, Takashi Nishimura, Mikio Furuse, Sa Kan Yoo.
    Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes.
    PLoS biology 2022;20(4):e3001586. DOI:10.1371/journal.pbio.3001586
  196. Oikawa T, Fukuda T, Yamashita T, Tomita H, Ozaki T.
    Lentiviral expression of calpain-1 C2-like domain peptide prevents glutamate-induced cell death in mouse hippocampal neuronal HT22 cells.
    In Vitro Cellular & Developmental Biology - Animal 2022;58:289-294. DOI:10.1007/s11626-022-00683-w
  197. Yuriko Saheki, Naoya Aoki, Koichi J Homma, Toshiya Matsushima.
    Suppressive Modulation of the Chick Forebrain Network for Imprinting by Thyroid Hormone: An in Vitro Study.
    Frontiers in physiology 2022;13:881947. DOI:10.3389/fphys.2022.881947
  198. Mai Izumida, Osamu Kotani, Hideki Hayashi, Chris Smith, Tsutomu Fukuda, Koushirou Suga, Masatomo Iwao, Fumito Ishibashi, Hironori Sato, and Yoshinao Kubo.
    Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2.
    Viruses 2022;14(4):816. DOI:10.3390/v14040816
  199. Miyanishi H, Kitazawa A, Izuo N, Muramatsu SI, Nitta A.
    N‐acetyl transferase, Shati/Nat8l, in the dorsal hippocampus suppresses aging‐induced impairment of cognitive function in mice.
    Neurochem Res. 2022;47(9):2703-2714. DOI:10.1007/s11064-022-03594-0
  200. Showkat Rashid, Yusuke Yoshigoe, Shinichi Saito.
    Phenanthroline based rotaxanes: recent developments in syntheses and applications.
    RSC Advances 2022;12(18):11318-11344. DOI:10.1039/D2RA01318E
  201. Hiroshi Gomi, Takahiro Nagumo, Kazushi Asano, Makoto Konosu, Tadashi Yasui, Seiji Torii, Masahiro Hosaka.
    Differential expression of secretogranin II and III in canine adrenal chromaffin cells and pheochromocytomas.
    Journal of Histochemistry & Cytochemistry 2022;70(5):335-356. DOI:10.1369/00221554221091000
  202. Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J Homma, Shinji Yamaguchi.
    Chick Hippocampal Formation Displays Subdivision- and Layer-Selective Expression Patterns of Serotonin Receptor Subfamily Genes.
    Frontiers in physiology 2022;13:882633. DOI:10.3389/fphys.2022.882633
  203. Danjo Y, Shigetomi E, Hirayama YJ, Kobayashi K, Ishikawa T, Fukazawa Y, Shibata K, Takanashi K, Parajuli B, Shinozaki Y, Kim SK, Nabekura J and *Koizumi S.
    Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice.
    J Exp Med. 2022;219(4):e20210989. DOI:10.1084/jem.20210989
  204. Hojo Y, Kishi S, Mori S, Fujiwara-Tani R, Sasaki T, Fujii K, Nakashima C, Luo Y, Shinohara H, Kuniyasu H.
    Sunitinib and pterostilbene combination treatment exerts anti-tumor effects in gastric cancer via suppression of PDZD8.
    Int J Mol Sci. 2022;23(7):4002. DOI:10.3390/ijms23074002
  205. 小山内 実
    マルチスケールカルシウムイメージング技術
    日本材料科学会誌 材料の科学と工学 2022;59:38-41.
  206. Owari T, Tanaka N, Nakai Y, Miyake M, Anai S, Kishi S, Mori S, Tani-Fujiwara R, ..., Hasegawa M, Fujimoto K, Kuniyasu H.
    5-Aminolevulinic acid sensitizes prostate cancer cells to radiation therapy and overcomes hypoxia-induced radiation resistance by enhancing mitochondrial reactive oxygen species production.
    Br J Cancer 2022;127(2):350-363. DOI:10.1038/s41416-022-01789-4
  207. Keita Anoyama, Gen Onodera, Tsutomu Fukuda, Masanari Kimura.
    C−H Silylation of 2-Arylpyridine Derivatives by Using Iridium Catalyst and Phosphine-Borane Ligand.
    Advanced Synthesis & Catalysis 2022;364(7):1223-1227. DOI:10.1002/adsc.202101476
  208. Niu J, Holland SM, Ketschek A, Collura KM, Hesketh NL, Hayashi T, Gallo G, Thomas G.
    Palmitoylation couples the kinases DLK and JNK3 to facilitate prodegenerative axon-to-soma signaling.
    Science Signaling 2022;15:eabh2674. DOI:10.1126/scisignal.abh2674
  209. Okada M, Kawagoe Y, Takasugi T, Nozumi M, Ito Y, Fukusumi H, Kanemura Y, Fujii Y, Igarashi M.
    JNK1-dependent phosphorylation of GAP-43 Serine 142 is a novel molecular marker for axonal growth.
    Neurochem Res. 2022;47:2668-2682. DOI:10.1007/s11064-022-03580-6
  210. Kaori Oka, Shusuke Fujioka, Yoshimi Kawamura, Kimi Araki, Kyoko Miura, et al.
    Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats.
    Communications biology 2022;5:287. DOI:10.1038/s42003-022-03241-y
  211. Kasahara Y, Masukawa D, Kobayashi K, Yamasaki M, Watanabe M, Goshima Y.
    L-DOPA-Induced Neurogenesis in the Hippocampus Is Mediated Through GPR143, a Distinct Mechanism of Dopamine.
    Stem Cells 2022;40(2):215-226. DOI:10.1093/stmcls/sxab013
  212. Ofusa, K., Chijimatsu, R., Ishii, H.
    Detection techniques for epitranscriptomic marks.
    American Journal of physiology 2022;322(4):C787-C793. DOI:10.1152/ajpcell.00460.2021
  213. Haruka Sato, Jun Hatakeyama, Takuji Iwasato, Kimi Araki, Nobuhiko Yamamoto, Kenji Shimamura.
    Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF.
    eLife 2022;11:e67549. DOI:10.7554/eLife.67549
  214. Naoya Aoki, Chihiro Mori, Toshiyuki Fujita, Shouta Serizawa, Shinji Yamaguchi, Toshiya Matsushima, Koichi J Homma.
    Imprintability of Newly Hatched Domestic Chicks on an Artificial Object: A Novel High Time-Resolution Apparatus Based on a Running Disc.
    Frontiers in physiology 2022;13:822638. DOI:10.3389/fphys.2022.822638
  215. Kimura Y, Saito H, Osaki T, Ikegami Y, Wakigawa T, Ikeuchi Y, and Iwasaki S.
    Mito-FUNCAT-FACS reveals cellular heterogeneity in mitochondrial translation.
    RNA 2022;28(6):895-904. DOI:10.1261/rna.079097.122
  216. Ryo Tanifuji, Naoto Haraguchi, Hiroki Oguri.
    Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC.
    Tetrahedron Chem. 2022;1:100010. DOI:10.1016/j.tchem.2022.100010
  217. Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yurika Tokunaga, Yoshinori Hasegawa, Kimi Araki, Yuichi Wakabayashi.
    Functional polymorphism in Pak1-3'UTR alters skin tumor susceptibility by alternative polyadenylation.
    Journal of Investigative Dermatology 2022;142(9):2323-2333.e12. DOI:10.1016/j.jid.2022.02.009
  218. Chihiro Mori, Naoya Aoki, Toshiyuki Fujita, Shinji Yamaguchi, Toshiya Matsushima, Koichi J Homma.
    Gene expression profiles of the muscarinic acetylcholine receptors in brain regions relating to filial imprinting of newly-hatched domestic chicks.
    Behavioural brain research 2022;420:113708. DOI:10.1016/j.bbr.2021.113708
  219. Wang C, Horigane SI, Wakamori M, Aleksic B, Takemoto-Kimura S et al.
    Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder.
    Transl Psychiatry 2022;12(1):84. DOI:10.1038/s41398-022-01851-y
  220. Takeda,Y., Chijimatsu,R., Ofusa, K., Kobayashi,Y., Doki,Y., Eguchi,.H., Ishii, H.
    Cancer metabolism challenges genomic instability and clonal evolution as therapeutic targets.
    Canser Science 2022;113(4):1097-1104. DOI:
  221. 岩崎信太郎
    ダイソームプロファイリング法によるリボソーム衝突の網羅探索
    Journal of Japanese Biochemical Society 2022;94(1):87-91. DOI:10.14952/SEIKAGAKU.2022.940087
  222. Sakai M, Yu Z, Hirayama R, Nakasato M, Kikuchi Y, Ono C, Komatsu H, Nakanishi M, Yoshii H, Stellwagen D, Furuyashiki T, Komatsu M, Tomita H.
    Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance.
    Neural Plast. 2022;,7503553. DOI:10.1155/2022/7503553
  223. Hikita T, Uehara R, Itoh RE, Mitani F, Miyata M, Yoshida T, Yamaguchi R, Oneyama C.
    MEK/ERK-mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function.
    Cancer Sci. 2022;113(4):264-1276. DOI:10.1111/cas.15288
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    Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction.
    Nature Aging 2022;2:105-114. DOI:10.1038/s43587-021-00167-8
  225. Tokio Katakura, Mikihiro Yoshida, Haruki Hisano, Hajime Mushiake, Kazuhiro Sakamoto.
    Reinforcement Learning Model with Dynamic State Space Tested on Target Search Tasks for Monkeys: Self-Determination of Previous States Based on Experience Saturation and Decision Uniqueness.
    Frontiers In Computational Neuroscience 2022;15:784592. DOI:10.3389/fncom.2021.784592
  226. Nakano M, Koga M, Hashimoto T, Matsushita N, Masukawa D, Mizuno Y, Uchimura H, Niikura R, Miyazaki T, Nakamura F, Goshima Y.
    Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.
    J Pharmacol Sci. 2022;148(2):214-220. DOI:10.1016/j.jphs.2021.11.008
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    Endosialin/CD248 may be a potential therapeutic target to prevent the invasion and metastasis in osteosarcoma.
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    Randamized lphase 2 study of perampanel for sporadic amyotrophic lateral sclerosis.
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  229. 竹馬俊介
    TRIM28は内在性レトロウイルスの抑制を通じ、T細胞免疫の暴走を抑制する
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    AHR and NRF2 in skin homeostasis and atopic dermatitis.
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    Serotonergic Neurons in the Chick Brainstem Express Various Serotonin Receptor Subfamily Genes.
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    Suppressive GLI2 fragment enhances liver metastasis in colorectal cancer.
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    A mass spectrometric method for in-depth profiling phosphoinositide regioisomers and their disease-associated regulation.
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    Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases.
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2021年度

  1. Sakamoto M, Inoue M, Takeuchi A, Kobari S, Yokoyama T, Horigane S, Takemoto-Kimura S, Abe M, Sakimura K, Kano M, Kitamura K, Fujii H, Bito H.
    A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo.
    Cell Reports Methods 2022;2:100168. DOI:10.1016/j.crmeth.2022.100168
  2. Shinji Kishimoto, Yuya Matsubara, Kenji Watanabe
    Alkaloid biosynthetic enzyme generates diastereomeric pair via two distinct mechanisms.
    Journal of the American Chemical Society 2022;144:5485-5493. DOI:10.1021/jacs.1c13621
  3. Akihito Yokosuka, Tatsuya Shimomura, Shohei Yokogawa, Airi Oguro, Katsunori Miyake, Yoshihiro Mimaki
    Chemical components from Hedera rhombea leaves and their cytotoxicity.
    Chemical and Pharmaceutical Bulletin 2022;70:175-181. DOI:10.1248/cpb.c21-00907
  4. Nae Saito, Makoto Itakura, Toshikuni Sasaoka
    D1 Receptor Mediated Dopaminergic Neurotransmission Facilitates Remote Memory of Contextual Fear Conditioning.
    Frontiers in Behavioral Neuroscience 2022;16:751053. DOI:10.3389/fnbeh.2022.751053
  5. Saegusa J, Osada Y, Miura K, Sasazawa Y, Ogura A, Takao KI, Simizu S.
    Elucidation of structure-activity relationship of humulanolides and identification of humulanolide analog as a novel HSP90 inhibitor.
    Bioorg Med Chem Lett 2022;60:128589. DOI:10.1016/j.bmcl.2022.128589
  6. Miura K, Kobayashi T, Zhang Z, Prasoon P, Hirose Y, Ishikawa H, Takizawa K, Sakata J, Miura S, Sasaoka T, Wakai T
    Establishment of a long-term survival swine model for observation of transplanted islets: A preliminary step in an allogeneic transplant experiment.
    Transplantation Proceedings 2022;54(2):507-512. DOI:10.1016/j.transproceed.2021.10.029
  7. Koji Kuraoka, Kae Nakamura
    Facial temperature and pupil size as indicators of internal state in primates.
    Neuroscience research 2022;175:25-37. DOI:10.1016/j.neures.2022.01.002
  8. Tanno N, Takemoto K, Takada-Horisawa Y, Shimada R., Fujimura S, Tani N., Takeda N., Araki K, Ishiguro K
    FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis.
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  176. Ryo Ishikawa, Mizuho Yasuda, Shogo Sasaki, Yue Ma, Kazuo Nagasawa, Masayuki Tera
    Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease.
    Chem. Commun., 2021;57:7236-7239. DOI:10.1039/D1CC03294A
  177. Shimo, S., Ushimaru, R., Engelbrecht, A., Harada, M., Miyamoto, K., Andreas, K., Uchiyama, M., Kaysser, L., Abe, I.
    Stereodivergent nitrocyclopropane formation during biosynthesis of belactosins and hormaomycins.
    J. Am. Chem. Soc. 2021;143:18413-18418. DOI:10.1021/jacs.1c10201
  178. Miyanishi H, Muramatsu SI, Nitta A
    Striatal Shati/Nat8l-BDNF pathways determine the sensitivity to social defeat stress in mice through epigenetic regulation.
    Neuropsychopharmacology 2021;14:1594-1605. DOI:10.1038/s41386-021-01033-2
  179. Yang, J., Mori, T., Wei, X., Matsuda, Y., Abe, I.
    Structural basis for isomerization reactions in fungal tetrahydroxanthone biosynthesis and diversification.
    Angew. Chem. Int. Ed. 2021;60:19458-19465. DOI:10.1002/anie.202107884
  180. Shepherd S., Lima M.A.P., Oliveira E.E., Sharkh S.M., Aonuma H., Jackson C.W., and Newland P.L.
    Sublethal neonicotinoid exposure attenuates the effects of electromagnetic fields on honey bee flight and learning.
    Environmental Advances 2021;4:100051. DOI:10.1016/j.envadv.2021.100051
  181. Hiroki Oguri*
    Synthesis and Structural Diversification of Artemisinins Towards the Generation of Potent Anti-malarial Agents.
    Chem. Lett. 2021;50:924-937. DOI:10.1246/cl.200920
  182. Kumiko Yoshinobu, Masatake Araki, Ayaka Morita, Miyuki Araki, Shun Kokuba, Naomi Nakagata, Kimi Araki
    Tamoxifen feeding method is suitable for efficient conditional knockout.
    Exp Anim 2021;70:91-100. DOI:10.1538/expanim.19-0138
  183. Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
    Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
    Inflamm Res. 2021;70:539-541. DOI:10.1007/s00011-021-01458-x
  184. Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
    Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling.
    PLoS One. 2021;16:e0248158. DOI:10.1371/journal.pone.0248158
  185. Kimura R, Yoshimura Y
    The contribution of low contrast–preferring neurons to information representation in the primary visual cortex after learning.
    Science Advances 2021;7(48):eabj9976. DOI:10.1126/sciadv.abj9976
  186. Kimura H, Sada R, Takada N, Harada A, Doki Y, Eguchi H, Yamamoto H, Kikuchi A
    The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancer.
    Oncogene 2021;40:4486-4502. DOI:10.1038/s41388-021-01860-z
  187. Hori, H., Itoh, M., Matsui, M., Kamo, T., Saito, T., Nishimatsu, Y, Kito, S., Kida, S., Kim, Y.
    The efficacy of memantine in the treatment of civilian posttraumatic stress disorder: an open label trial.
    European Journal of Psychotraumatology 2021;12:1:1859821. DOI:10.1080/20008198.2020.1859821
  188. Nakayama Jun, Han Yuxuan, Kuroiwa Yuka, Azuma Kazushi, Yamamoto Yusuke, Semba Kentaro,
    The In Vivo Selection Method in Breast Cancer Metastasis.
    International Journal of Molecular Sciences 2021;22:1886. DOI:10.3390/ijms22041886
  189. Kazuhiro Okumura(第一著者), Megumi Saito, Eriko Isogai, and Yuichi Wakabayashi(責任著者)
    The Japanese Wild-Derived Inbred Mouse Strain, MSM/Ms in Cancer Research.
    Cancers (Basel). 2021;13(5):1026. DOI:10.3390/cancers13051026
  190. Michio Sato, .. Kumiko Yoshinobu, Mai Imasaka, Masatake Araki, .. Kimi Araki, Yuichi Oike
    The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis.
    Nat Commun 2021;12:2529. DOI:10.1038/s41467-021-22735-7
  191. Takeuchi Y, Kimura N, Murayama T, et al, Gotoh N
    The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis.
    Proc. Natl, Acad, Sci, USA 2021;vol.118:e2103658118. DOI:10.1073/pnas.2103658118
  192. Ryo Yoshikawa, Koichiro Abe
    The multi-kinase inhibitor dasatinib suppresses autoinflammation and increases bone density in a mouse model for chronic recurrent multifocal osteomyelitis.
    Cell Biochem Funct. 2021;39:521-527. DOI:10.1002/cbf.3617
  193. Mariko Ito, Masashi Nagase, Suguru Tohyama, Kaori Mikami, Fusao Kato, Ayako M Watabe.
    The parabrachial-to-amygdala pathway provides aversive information to induce avoidance behavior in mice.
    Molecular Brain 2021;14:94. DOI:10.1186/s13041-021-00807-5
  194. Nishio N, Hayashi K, Ishikawa AW, Yoshimura Y
    The role of early visual experience in the development of spatial-frequency preference in the primary visual cortex.
    The Journal of Physiology 2021;599(17):4131-4152. DOI:10.1113/JP281463
  195. Furuya K, Wu T, Orimoto A, Sugano E, Tomita H, Kiyono T, Kurose T, Takai Y, Fukuda T
    The transcriptome of wild-type and immortalized corneal epithelial cells.
    Sci Data 2021;8(1):126. DOI:10.1038/s41597-021-00908-9
  196. Shimatani H, Inoue Y, Maekawa Y, Miyake T, Yamaguchi Y, and Doi M
    Thermographic imaging of mouse across circadian time reveals body surface temperature elevation associated with non-locomotor body movements.
    PLoS One 2021;16:e0252447. DOI:10.1371/journal.pone.0252447
  197. Miyahara H, Natsumeda M, Kanemura Y, Yamasaki K, Yoshimura J, Fujii Y, Suenobu S, Ihara K, Hara J, Kakita A, Yoshida M, Iwasaki Y
    Topoisomerase IIβ immunoreactivity (IR) co-localizes with neuronal marker-IR but not glial fibrillary acidic protein-IR in GLI3-positive medulloblastomas: an immunohistochemical analysis of 124 medulloblastomas from the Japan Children's Cancer Group.
    Brain Tumor Pathol 2021;49(3):527-534. DOI:10.1007/s10014-021-00396-0
  198. Hiroyuki Saiga, Masaki Ueno, Takashi Tanaka, Tsuneyasu Kaisho, Katsuaki Hoshino
    Transcription factor MafB-mediated inhibition of type I interferons in plasmacytoid dendritic cells.
    International Immunology 2021:dxab103. DOI:10.1093/intimm/dxab103
  199. Doi M, Oka Y, Taniguchi M, Sato M.
    Transient expansion of the expression region of Hsd11b1, encoding 11β-hydroxysteroid dehydrogenase type 1, in the developing mouse neocortex.
    J. Neurochem 2021;159:778-788. DOI:10.1111/jnc.15505
  200. Nguyen LKC, Shimizu A, Soh JEC, Komeno M, Sato A, Ogita H.
    Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through αB-crystallin intracellular dynamics.
    J Biochem 2021;170(5):577-585. DOI:10.1093/jb/mvab066
  201. Takahashi, S., Fukushima, H., Yu, Z., Tomita, H., Kida, S.*
    Tumor necrosis factor α negatively regulates the retrieval and reconsolidation of hippocampus-dependent memory.
    Brain, Behavior, and Immunity 2021;94:79-88. DOI:10.1016/j.bbi.2021.02.033
  202. Iori Ohmori, Mamoru Ouchida, Hirohiko Imai, Saeko Ishida, Shinya Toyokuni, Tomoji Mashimo
    Txn1 mutation causes epilepsy associated with vacuolar degeneration in the midbrain.
    bioRxiv 2021:in press. DOI:10.1101/2021.10.07.463470
  203. Inukai, S., Hara, S., and Ichinose, H.
    Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue.
    Biochem. Biophys. Res. Commun. 2021;589:209-214. DOI:10.1016/j.bbrc.2021.12.024
  204. Kawakami T, Fujisawa H, Nakayama S, Yoshino Y, Hattori S, Seino Y, Takayanagi T, Miyakawa T, Suzuki A, Sugimura Y.
    Vasopressin escape and memory impairment in a model of chronic syndrome of inappropriate secretion of antidiuretic hormone in mice.
    Endocrine Journal 2021;68:31-43. DOI:10.1507/endocrj.EJ20-0289
  205. Yuki Takakura, Naoto Hori, Natsumi Terada, Moeka Machida, Naoto Yamaguchi, Hiroyuki Takano, Noritaka Yamaguchi
    VGLL3 activates inflammatory responses by inducing interleukin-1α secretion.
    FASEB Journal 2021;11:e21996. DOI:10.1096/fj.202100679RR
  206. Yue Ma, Yuki Wakabayashi, Naruyuki Watatani, Ryota Saito, Takatsugu Hirokawa, Masayuki Tera, Kazuo Nagasawa
    Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand.
    Org. Biomol. Chem 2021;19(37):8035-8040. DOI:10.1039/D1OB01500A
  207. Nakamura E., Hata K., Takahata Y., Kurosaka H., Abe M., et al
    Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix.
    Commun. Biol. 2021:1258. DOI:10.1038/s42003-021-02793-9
  208. Barra, L., Awakawa, T., Shirai, K., Hu, Z., Bashiri, G., Abe, I.
    β-NAD as a Building Block in Natural Product Biosynthesis.
    Nature 2021;600:754-758. DOI:10.1038/s41586-021-04214-7
  209. 山中章弘
    オレキシンと情動.
    生体の科学 2021;72(5):475-477.
  210. 藤原和之、柿崎利和、姜玮茹、宮田茂雄、柳川右千夫
    ノックアウトラットによる2種類のGABA合成酵素アイソフォームの機能的役割の解明.
    細胞 2021;53:443-447.
  211. 吉田 香,魏 民,藤岡正喜,寺本 勲
    高脂肪食摂取加齢マウスにおける亜鉛の長期間過剰投与が学習・記憶能に及ぼす影響.
    Trace Nutrients Research 2021;38:7-13.
  212. 松本真司
    上皮管腔形態形成の分子機構とその異常による腫瘍形成.
    Journal of Japanese Biochemical Society 2021;93:733-748. DOI:10.14952/SEIKAGAKU.2021.930733
  213. 福田茉由, 向井淳
    統合失調症の認知機能障害を改善するエピゲノム治療薬の開発.
    精神科 2021;38(2):220-228.
  214. 土田陸平, 住谷昌彦, 阿部博昭, 内田寛治
    疼痛医学におけるPrecision Medicine(精密医療)-P2Y12受容体と痛み.
    臨床麻酔 2021;45:137-145.
  215. 冉慶松、周啓亮、小田佳奈子、泰江章博、阿部学、笹岡俊邦、崎村建司、味岡洋一、西條康夫
    胚盤胞補完法とES細胞を用いた甲状腺再生.
    日本再生医療学会総会(Web) 2021;20:ROMBUNNO.P-01-03.
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    胚盤胞補完法を用いた多能性幹細胞由来肺の作出.
    日本呼吸器学会誌(Web) (Annals of the Japanese Respiratory Society (Web)) 増刊号 2021;10
  217. Kon, S. and Fujita, Y.
    Cell competition-induced apical elimination of transformed cells, EDAC, orchestrates the cellular homeostasis.
    Developmental Biology 2021;476:112-116. DOI:10.1016/j.ydbio.2021.03.015

2020年度

  1. Shutoh F, Masuda T, Sasaki T, Takei Y.
    Anomalous atrium associated with persistent left superior vena cava.
    Anatomical Science International. -:2021, 1-5. DOI:10.1007/s12565-021-00604-z
  2. Asano T, Teh DBL, Yawo H.
    Application of Optogenetics for Muscle Cells and Stem Cells.
    Adv Exp Med Biol. 1293:2021, 359-375. DOI:10.1007/978-981-15-8763-4_23
  3. M. Sumiyoshi, Y. Kotani, Y. Ikuta, K. Suzue, M. Ozawa, T. Katakai, T. Yamada, T. Abe, K. Bando, S. Koyasu, Y. Kanaho, T. Watanabe and S. Matsuda
    Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation.
    The Journal of Immunology 206:2021, 366-375. DOI:10.4049/jimmunol.2000971
  4. Ishida A, Igarashi K, Ruike Y, Ishiwata K, Naito K, Kono S, Deguchi H, Fujimoto M, Shiga A, Suzuki S, Yoshida T, Tanaka T, Tatsuno I, Yokote K, Koide H.
    Association of urinary free cortisol with bone formation in patients with mild autonomous cortisol secretion.
    Clin Endocrinol (Oxf). 94:2021, 544-550. DOI:10.1111/cen.14385
  5. Fujihara K, Sato T, Higeta K, Miyasaka Y, Mashimo T, Yanagawa Y.
    Behavioral consequences of a combination of Gad1 haplodeficiency and adolescent exposure to NMDA receptor antagonist in Long-Evans rat.
    Front Pharmacol. 12:2021, 646088. DOI:10.3389/fphar.2021.646088
  6. Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Maenaka K, Shimada T, Fukata M, Nishijo H, Takao K, Okabe S, Tabuchi K, Mishina M, Mori H, Fukai S.
    Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.
    Nature Communications 12(1):2021, 1848. DOI:10.1038/s41467-021-22059-6
  7. Adhikara IM, Yagi K, Mayasari DS, Suzuki Y, Ikeda K, Ryanto GRT, Sasaki N, Rikitake Y, Nadanaka S, Kitagawa H, Miyata O, Igarashi M, Hirata K, Emoto N
    Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
    Arterioscler Thromb Vasc Biol 41(3):2021, 1076-1091. DOI:10.1161/ATVBAHA.120.315789
  8. Fumito Ishibashi, Tsutomu Fukuda, Shijiao Zha, Aya Hashirano, Shotaro Hirao, Masatomo Iwao
    Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin.
    Bioscience, Biotechnology, and Biochemistry 85:2021, 181-191. DOI:10.1093/bbb/zbaa028
  9. Sasaki T, Takei Y.
    Constitutive increase of IL-17A in serum affects microglial activity in the hippocampal dentate gyrus.
    Jap J Biol Psych. 32(2):2021, in press.
  10. Shimizu T, Takahashi N, Huber VJ, Asawa Y, Ueda H, Yoshimori A, Muramatsu Y, Seimiya H, Kouji H, Nakamura H, Oguri H.
    Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α.
    Bioorg Med Chem. 30:2021, 115949. DOI:10.1016/j.bmc.2020.115949
  11. Doi H, Parajuli B, Horio T, Shigetomi E, Shinozaki Y, Noda T, Takahashi K, Hattori T, Koizumi S, Sawada K
    Development of a label-free ATP image sensor for analyzing spatiotemporal patterns of ATP release from biological tissues.
    Sensors and Actuators B: Chemical 335:2021, 129686. DOI:10.1016/j.snb.2021.129686
  12. Suzuki T, Ogita H, Sato A, Minamidate N, Hachiro K.
    Differences between atherosclerotic and non-atherosclerotic patients in expression levels of inflammatory mediators in the adipose tissue around the coronary artery.
    Int Heart J -:2021, in press. DOI:10.1536/ihj.20-585
  13. Katagiri T, Ushiki T, Nakajima-Takagi Y, Oshima M, Mikami T, Kawasaki A, Ishiguro H, Tanaka T, Sone H, Kitagawa H, Igarashi M, Iwama A, Masuko M
    Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis.
    Exp Hematol 96:2021, 52-62. DOI:10.1016/j.exphem.2021.02.003
  14. Tsutomu Fukuda, Seiya Okutani, Mayu Sumi, Kazuhito Miyagi, Gen Onodera, Masanari Kimura
    Divergent Total Synthesis of Azalamellarins D and N.
    Heterocycles 103:2021, in press. DOI:10.3987/COM-20-S(K)53
  15. Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K.
    Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons.
    Biomedicines 9 (1):2021, E49. DOI:10.3390/biomedicines9010049
  16. Ito, N., Riyadh, M., Ahmad, S., Hattori, S., Miyakawa, T. and Ohta, K. et al.
    Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice.
    Science Translational Medicine 13(587):2021, eaay7896. DOI:10.1126/scitranslmed.aay7896
  17. Sasaki T, Nagata R, Takahashi S, Takei Y
    Effects of RORγt overexpression on the murine central nervous system.
    Neuropsychopharmacology Reports -:2021, 1-9. DOI:10.1111/NPR2.12162
  18. Hikmawan Wahyu Sulistomo, Takayuki Nemoto, Yohko Kage, Hajime Fujii, Taku Uchida, Kogo Takamiya, Hideki Sumimoto, Hiroaki Kataoka, Haruhiko Bito, Ryu Takeya
    Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.
    Cerebral Cortex -:2021, in press. DOI:10.1093/cercor/bhaa355
  19. Fujihara K, Sato T, Miyasaka Y, Mashimo T, Yanagawa Y.
    Genetic deletion of the 67-kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats.
    FEBS Open Bio. -:2021, in press. DOI:10.1002/2211-5463.13065
  20. Sumitani M, Nishizawa D, Hozumi J, Ikeda K.
    Genetic implications in quality palliative care and preventing opioid crisis in cancer-related pain management.
    Journal of Neuroscience Research -:2021, in press. DOI:10.1002/jnr.24756
  21. Natsumeda M, Miyahara H, Yoshimura J, Okada M, Hirato J, Wataya T, Tateishi K, Rodriguez FJ, Suva ML, Taylor MD, Eberhart CG, Fujii Y, Kakita A
    GLI3 is associated with neuronal differentiation in SHH-activated and WNT-activated medulloblastoma.
    Journal of Neuropathology and Experimental Neurology 80(2):2021, 129-136. DOI:10.1093/jnen/nlaa141
  22. Miyata S, Kakizaki T, Fujihara K, Obinata H, Hirano T, Nakai J, Tanaka M, Itohara S, Watanabe M, Tanaka KF, Abe M, Sakimura K, Yanagawa Y.
    Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice.
    Mol Brain. 14:2021, 5. DOI:10.1186/s13041-020-00713-2
  23. Matsumoto K, Okamoto K, Okabe S, Fujii R, Ueda K, Ohashi K, Seimiya H.
    G-quadruplex-forming nucleic acids interact with SF3B2 and suppress innate immune gene expression.
    Genes Cells 26:2021, 65-82. DOI:10.1111/gtc.12824
  24. Dat NQ, Oikawa D, Yoishizato K, Tokunaga F, Pinzani M, Kawada M, et al.
    His-Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
    Hepatology. -:2021, in press.
  25. Kumiko Naito,Sawako Suzuki,Chikako Ohwada,Jun-ichiro Ikeda,Tomoaki Tanaka,Koutaro Yokote.
    ICAM1-Negative Intravascular Large B-Cell Lymphoma of the Pituitary Gland: A Case Report and Literature Review.
    AACE Clinical Case Reports -:2021, in press. DOI:10.1016/j.aace.2021.01.011
  26. Aoki H, Abe C, Hara A, Miyazaki T, Morita H, Kunisada T.
    Induced genetic ablation of Rest leads to the alteration of stimulus-induced response of the vagal nerve.
    Genes Cells. 26(2):2021, 45-55. DOI:10.1111/gtc.12819
  27. Toshinori Matsuoka, Miwako Yamasaki, Manabu Abe, Yukiko Matsuda, Hiroyuki Morino, Hideshi Kawakami, Kenji Sakimura, Masahiko Watanabe, Kouichi Hashimoto
    Kv11 (ether-à-go-go-related gene) voltage-dependent K+ channels promote resonance and oscillation of subthreshold membrane potentials.
    Journal of Physiology (London) 599:2021, 547-569. DOI:10.1113/JP280342
  28. Nishiya N, Oku Y, Ishikawa C, Fukuda T, Dan S, Mashima T, Ushijima M, Matsuura M, Tomida A, Seimiya H, Yamori T, Iwao M, Uehara Y et al.
    Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor.
    Cancer Sci. -:2021, in press. DOI:10.1111/cas.14839
  29. T Shimizu, K Kimura, E Sugihara, S Yamaguchi‐Iwai, H Nobusue, O Sampetrean, Y Otsuki, Y Fukuchi, K Saitoh, K Kato, T Soga, A Muto, H Saya
    MEK inhibition preferentially suppresses anchorage‐independent growth in osteosarcoma cells and decreases tumors in vivo.
    Journal of Orthopaedic Research -:2021, in press. DOI:10.1002/jor.25023
  30. Asada-Utsugi M, Uemura K, Noda Y, 他8名, Takahashi R, Hattori S, Miyakawa T, Ageta-Ishihara N, Kobayashi K, Kinoshita M, Kinoshita A.
    Mice with a cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial memory tasks.
    Molecular Brain 14(1):2021, 23. DOI:10.1186/s13041-021-00738-1
  31. Tesshu Hori, Shohei Ikuta, Satoko Hattori, Keizo Takao, Tsuyoshi Miyakawa, Chieko Koike
    Mice with mutations in Trpm1, a gene within the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior.
    Molecular Brain 14(1):2021, 61. DOI:10.1186/s13041-021-00749-y
  32. Mushiake H, Ohshiro T, Osawa SI, Hosaka R, Katayama N, Tanaka T, Yawo H, Osanai M.
    Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits.
    Adv Exp Med Biol. 1293:2021, 501-509. DOI:10.1007/978-981-15-8763-4_34
  33. Arima Y, Nakagawa Y, Takeo T, Ishida T, Yamada T, Hino S, Yamagata K, Nakamura T, Nakagata N, Tsujita K
    Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.
    Nature Metabolism 3:2021, 196-210. DOI:10.1038/s42255-021-00342-6
  34. Aki Takahashi, Hossein Aleyasin, Tetsuya Sasaki, Sonoko Ogawa, Bruce S. McEwen and Scott J. Russo et al
    Neuromodulatory effect of interleukin 1 in the dorsal raphe nucleus on individual differences in aggression.
    Molecular Psychiatry -:2021, in press.
  35. Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Matsumoto H, Miyakawa T, Nakada K.
    Neuronal degeneration and cognitive impairment can be prevented via the normalization of mitochondrial dynamics.
    Pharmacol Res. 163:2021, 105246. DOI:10.1016/j.phrs.2020.105246
  36. Tatsuya Yamahira, Gen Onodera, Tsutomu Fukuda, Masanari Kimura
    Ni-catalyzed direct carboxylation of propargylic alcohols with carbon dioxide.
    Chemistry Letters -:2021, in press. DOI:10.1246/cl.210008
  37. Ying Luo, Bun Chan, Tsutomu Fukuda, Gen Onodera, Masanari Kimura
    Nickel-​Catalyzed Carboxylation of Conjugated Dienes with Carbon Dioxide and DIBAL-​H for the Synthesis of β,​γ-​Unsaturated Carboxylic Acids.
    Synlett -:2021, in press. DOI:10.1055/a-1336-8034
  38. Mori T, Kido A, Kawahara I, Nukaga S, Miyagawa Y, Goto K, Mori S, Kishi S, Fujii K, Fujiwara-Tani R, Kuniyasu H
    Nutritional intervention for cancer sarcopenia.
    Ann Muscloskeletal Med 5(1):2021, 001-004. DOI:10.17352/amm.000024
  39. Akira C Saito, Tomohito Higashi, Yugo Fukazawa, Tetsuhisa Otani, Masashi Tauchi, Atsuko Y Higashi, Mikio Furuse, Hideki Chiba
    Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function.
    Molecular biology of the cell -:2021, in press. DOI:10.1091/mbc.E20-07-0464
  40. Ando S, Fukamachi K, Yoshimoto E, Matsumoto H, Iinuma M and Suzui M.
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    Phosphorylation of the Anaphase Promoting Complex activator FZR1/ CDH1 is required for Meiosis II entry in mouse male germ cell.
    Scientific Reports 10:2020, 10094. DOI:10.1038/s41598-020-67116-0
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    Proliferative Classification of intracranially injected HER2-positive Breast Cancer Cell Lines.
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    Role of Clostridium perfringens enterotoxin on YAP activation in colonic sessile serrated adenoma/polyp with dysplasia.
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    Serotonergic control in initiating defensive responses to unexpected tactile stimuli in the trap-jaw ant Odontomachus kuroiwae.
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    Sexually dimorphic role of oxytocin in medaka mate choice.
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    SGLT2 inhibition mediates protection from diabetic kidney disease by promoting ketone body-induced mTORC1 inhibition.
    Cell Metab. 32:2020, 404-419. DOI:10.1016/j.cmet.2020.06.020
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    Steroid metabolites for diagnosing and predicting clinicopathological features in cortisol-producing adrenocortical carcinoma.
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    Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress.
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    Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons.
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    The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression.
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    Time-restricted G-protein signaling pathways via GPR176, Gz, and RGS16 set the pace of the master circadian clock in the suprachiasmatic nucleus.
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2019年度

  1. Kataoka, N., Shima, Y., Nakajima, K., Nakamura, K.
    A central master driver of psychosocial stress responses in the rat.
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  2. Hamm JP, Shymkiv Y, Mukai J, Gogos JA, Yuste R.
    Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a+/- Mice.
    Biological Psychiatry in Press:2020, in Press. DOI:10.1016/j.biopsych.2020.01.004
  3. Wada S, Yanagida J, Sasase H, Zhang T, Li X, Kamii H, Domoto M, Deyama S, Hinoi E, Yamanaka A, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K
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  168. Inami C, Tanihira H, Kikuta S, Ogasawara O, Sobue K, Kume K, Osanai M, Ohsawa M
    Visualization of brain activity in a neuropathic pain model using quantitative activity-dependent manganese magnetic resonance imaging.
    Frontiers in Neural Circuits 13:2019, 74. DOI:10.3389/fncir.2019.00074
  169. 勢力 薫、笠井 淳司、中澤 敬信、丹生 光咲、中 雄一郎、田沼 将人、五十嵐 久人、山浦 港生、早田 敦子、吾郷 由希夫、橋本均
    Whole-brain Block-Face Serial Microscopy Tomography at Subcellular Resolution Using FAST.
    Nat Protoc 14 (5):2019, 1509-1529. DOI:10.1038/s41596-019-0148-4
  170. Sadaiwa Yorimoto, Akira Tsubouchi, Haruki Mizoguchi, Hideaki Oikawa, Yoshiaki Tsunekawa, Tomoya Ichino, Satoshi Maeda and Hiroki Oguri
    Zn(OTf)2-mediated annulations of N-propargylated tetrahydrocarbolines: divergent synthesis of four distinct alkaloidal scaffolds.
    Chemical Science 10:2019, 5686-5698. DOI:10.1039/C9SC01507H
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    骨転移とマイクロRNA.
    BIO Clinica 34(9):2019, 794-798.
  172. 菊田 里美, 笠原 二郎, 小山内 実
    定量的マンガン造影MRI を用いた疾患モデル動物の神経活動計測.
    日本放射線技術学会雑誌 75(8):2019, 799-804.

2018年度

  1. Hiroaki Tagaya, Kosuke Ishikawa, Yoshito Hosokawa, Shun Kobayashi, Yukino Ueoka, Mayuna Shimada, Yasuko Ohashi, Hirofumi Mikami, Mizuki Yamamoto, Tatsuya Ihara, Kentaro Kumazawa, Kosuke Sugihara, Naoki Goshima, Shinya Watanabe and Kentaro Semba
    A method of producing genetically manipulated mouse mammary gland.
    Breast Cancer Research 21:1, 2019. DOI:10.1186/s13058-018-1086-8
  2. Saito M, Okumura K, Isogai E, Araki K, Tanikawa C, Matsuda K, Kamijo T, Kominami R, Wakabayashi Y.
    A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway.
    Journal of Investigative Dermatology 139(7):1459-1469, 2019. DOI:10.1016/j.jid.2018.12.027
  3. Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Tani H, Mito T, Matsumoto H, Miyakawa T, Nakada K.
    Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior.
    Journal of Neuroscience 39(9):1588-1604, 2019. DOI:10.1523/JNEUROSCI.2139-18.2018
  4. Kurosaki H, Yamaguchi K, Man-Yoshi K, Muramatsu SI, Hara S, Ichinose H
    Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP.
    Neurochemistry International 125:16-24, 2019. DOI:10.1016/j.neuint.2019.02.005
  5. Saitoh, S. I., Y. M. Saitoh, K. Kontani, K. Sato, and K. Miyake.
    ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus.
    Int Immunol. :in press, 2019. DOI:10.1093/intimm/dxy084
  6. Egawa R, Yawo H.
    Analysis of Neuro-Neuronal Synapses Using Embryonic Chick Ciliary Ganglion via Single-Axon Tracing, Electrophysiology, and Optogenetic Techniques.
    Curr Protoc Neurosci. :e64, 2019. DOI:10.1002/cpns.64
  7. Ikeda K, Kaneko R Yanagawa Y, Ogawa M,et al.
    Analysis of the neuronal network of the medullary respiratory center in transgenic rats expressing archaerhodopsin-3 in Phox2b-expressing cells.
    Brain Res Bull 144:39-45, 2019. DOI:10.1016/j.brainresbull.2018.11.005
  8. Nam SA, Kim WY, Kim JW, Park SH, Kim HL, Lee MS, Komatsu M, Ha H, Lim JH, Park CW, Yang CW, Kim J, Kim YK.
    Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway.
    Cell Death Dis. 10(2):535-540, 2019. DOI:10.1038/s41419-019-1356-0
  9. Saito T., Komatsu M. (19人中19番目)
    Autophagy regulates lipid metabolism through selective turnover of NCoR1.
    Nat.Commun. 10:1567, 2019. DOI:10.1038/s41467-019-08829-3
  10. Hashimoto K, Sato S, Ochi H, Takeda S, Futakuchi M
    Calvarial Bone Implantation and in vivo Imaging of Tumor Cells in Mice.
    Bio Protoc 9(3):e3151, 2019. DOI:10.21769/BioProtoc.3151
  11. Akichika S., Hirano S., Shichino Y., Suzuki T., Nishimasu H., Ishitani R., Sugita A., Hirose Y., Iwasaki S., Nureki O., and Suzuki T.
    Cap-specific terminal N6-methylation of RNA by an RNA polymerase II-associated methyltransferase Cap.
    Science 11(363):6423, 2019. DOI:10.1126/science.aav0080
  12. Saitoh F, Hagiwara H, Wakatsuki S, Araki T.
    Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency.
    Neuroscience Resarch 139:58-62, 2019. DOI:10.1016/j.neures.2018.08.015
  13. Ohta K, Aoyama E, Ahmad SAI, Ito N, Anam MB, Kubota S, Takigawa M.
    CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.
    J Cell Commun Signal. 13(1):113-118, 2019. DOI:10.1007/s12079-018-0487-x
  14. Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M.
    Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.
    Nautre communications 10 (1):981, 2019. DOI:10.1038/s41467-019-08957-w
  15. Harada, T., Matsumoto, S., Hirota, S., Kimura, H., Fujii, S., Kasahara, Y., Gon, H., Yoshida, T., Itoh, T., Haraguchi, N., Mizushima, T., Noda, T., Eguchi, H., Nojima, S., Morii, E., Fukumoto, T., Obika, S., Kikuchi, A.
    Chemically modified antisense oligonucleotide against ARL4C inhibits primary and metastatic liver tumor growth.
    Mol. Cancer Ther. 18:602-612, 2019. DOI:10.1158/1535-7163.MCT-18-082
  16. Orimo, T., I. Sasaki, H. Hemmi, T. Ozasa, Y. Fukuda-Ohta, T. Ohta, M. Morinaka, M. Kitauchi, T. Yamaguchi, Y. Sato, T. Tanaka, K. Hoshino, K. I. Katayama, S. Fukuda, K. Miyake, M. Yamamoto, T. Satoh, K. Furukawa, E. Kuroda, K. J. Ishii, K. Takeda, and T. Kaisho.
    Cholera toxin B induces interleukine-1β production from resident peritoneal macrophages through pyrin as well as NLRP3 inflammasome.
    Int Immunol. :in press, 2019. DOI:10.1093/intimm/dxz004
  17. Adhikara IM, *Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata K, Emoto N
    Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.
    Biochem Biophys res Commun 509:89-95, 2019. DOI:10.1016/j.bbrc.2018.12.068
  18. Kimura H, Yamamoto H, Harada T, Fumoto K, Osugi Y, Sada R, Maehara N, Hikita H, Mori S, Eguchi H, Ikawa M, Takehara T, Kikuchi A.
    CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy.
    Clin Cancer Res. 25:1936-1947, 2019. DOI:10.1158/1078-0432.CCR-18-2124
  19. Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.
    CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.
    Oncogene 14:2580-2594, 2019. DOI:10.1038/s41388-018-0603-7
  20. Bando Y*, Sakamoto M* (Co-first and corresponding author), Kim S, Ayzenshtat I, Yuste R.
    Comparative evaluation of genetically encoded voltage indicators.
    Cell Reports 26(3):802-813, 2019. DOI:10.1016/j.celrep.2018.12.088
  21. Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
    Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy.
    Pathobiology 86:182-189, 2019. DOI:10.1159/000496027
  22. Furusho, K., T. Shibata, R. Sato, R. Fukui, Y. Motoi, Y. Zhang, S. I. Saitoh, T. Ichinohe, M. Moriyama, S. Nakamura, and K. Miyake.
    Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.
    Int Immunol. 31:167-173, 2019. DOI:10.1093/intimm/dxy075
  23. Naniwa K., Sugimoto Y., Osuka K. and Aonuma H.
    Defecation initiates walking in the cricket Gryllus bimaculatus.
    J. Insect Physiol. 112:117-122, 2019. DOI:10.1016/j.jinsphys.2018.11.004
  24. Sashida G, Oshima M, Iwama A.
    Deregulated Polycomb functions in myeloproliferative neoplasms.
    Int J Hematol 110(2):170-178, 2019. DOI:10.1007/s12185-019-02600-6
  25. Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
    Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.
    Oncogene 38:635-655, 2019. DOI:10.1038/s41388-018-0481-z
  26. Serita, T., Miyahara, M., Tanimizu, T., Takahashi, S., Oishi, S., Nagayoshi, T., Tsuji, R., Inoue, H., Uehara, M., Kida, S*.
    Dietary magnesium deficiency impairs hippocampus-dependent memories without changes in the spine density and morphology of hippocampal neurons in mice.
    Brain Res Bull. 144:149-157, 2019. DOI:10.1016/j.brainresbull.2018.11.019
  27. Yoshitomi S, Takahashi Y, Imai K, Koshimizu E, Miyatake S, Nakashima M, Saitsu H, Matsumoto N, Kato M, Fujita T, Ishii A, Hirose S, Inoue Y.
    Different types of suppression-burst patterns in patients with epilepsy of infancy with migrating focal seizures (EIMFS).
    Seizure 65:118-123, 2019. DOI:10.1016/j.seizure.2019.01.009
  28. Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Mizutani A, et al.
    Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
    Journal of Medicinal Chemistry 62(7):3407-3427, 2019. DOI:10.1021/acs.jmedchem.8b01888
  29. Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI.
    Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
    J. Exp. Med. 216:950-965, 2019. DOI:10.1084/jem.20180900
  30. Takanori NOZAWA, Masayasu OKADA, Manabu NATSUMEDA, Takeyoshi EDA, Hideaki ABE, Yoshihiro TSUKAMOTO, Kouichirou OKAMOTO, Makoto OISHI, Hitoshi TAKAHASHI, Yukihiko FUJII, and Akiyoshi KAKITA
    EGFRvIII is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma.
    Neurologia medico-chirurgica (Tokyo) 59(3):89-97, 2019. DOI:10.2176/nmc.oa.2018-0078
  31. Tome S, Sasaki T, Takahashi S, Takei Y.
    Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic-polycytidylic acid in inducing fetal loss.
    Experimental Animals Volume 68 Issue 4:491-497, 2019. DOI:10.1538/expanim.19-0038
  32. Noritake A, Nakamura K.
    Encoding prediction signals during appetitive and aversive Pavlovian conditioning in the primate lateral hypothalamus.
    Journal of neurophysiology 121(2):396-417, 2019. DOI:10.1152/jn.00247.2018
  33. Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N
    Forkhead box protein A1 confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.
    J Cell Biochem. 120:2259-2270, 2019. DOI:10.1002/jcb.27551
  34. Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H.
    Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo.
    J Physiol Sci. 69(1):65-77, 2019. DOI:10.1007/s12576-018-0618-4
  35. Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K.
    Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.
    Addict Biol 25(1):e12723, 2019. DOI:10.1111/adb.12723
  36. Jun Watanabe, Manabu Natsumeda, Masayasu Okada, Daiki Kobayashi, Yu Kanemaru, Yoshihiro Tsukamoto, Makoto Oishi, Akiyoshi Kakita, Yukihiko Fujii
    High detection rate of MYD88 mutations in cerebrospinal fluid from patients with central nervous system lymphomas.
    JCO Precision Oncology :in press, 2019.
  37. Kamil M, Shinsato Y, Higa N, Hirano T, Idogawa M, Takajo T, Minami K, Shimokawa M, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K.
    High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme.
    British Journal of Cancer 120(8):819-826, 2019. DOI:10.1038/s41416-019-0413-x
  38. Htun Y, Nakamura S, Nakao Koyano K, Ohta K, Morimoto A, Wakabayashi T, Sugino M, Fujioka K, Kato I, Kondo S, Yasuda S, Miki T, Ueno M, Kusaka T
    Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.
    Scientific Reports 9:4088, 2019. DOI:10.1038/s41598-019-40674-8
  39. Umehara T, Mori R, Mace K, Murase T, Abe Y, Yamamoto T, Ikematsu K
    Identification of specific microRNAs in neutrophils of type 2 diabetic mice: overexpression of microRNA-129-2-3p accelerates diabetic wound healing.
    Diabetes 68(3):617-630, 2019. DOI:10.1124/jpet.118.253922
  40. Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
    Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
    Neuroscience Resarch 139:63-68, 2019. DOI:10.1016/j.neures.2018.08.016
  41. Yosuke Takei, Saki Tome, Tetsuya Sasaki
    Intracellular transport of NMDA receptors and Schizophrenia.
    Japanese Journal of Biological Psychiatry :in press, 2019.
  42. *Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, R?os A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y
    Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.
    The Journal of Neuroscience 39(3):485-502, 2019. DOI:10.1523/JNEUROSCI.1584-18.2018
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    Iron Addiction with Ferroptosis-resistance in Asbestos-induced Mesothelial Carcinogenesis: Toward the Era of Mesothelioma Prevention.
    Free Radical Biology & Medicine 133:206-215, 2019. DOI:10.1016/j.freeradbiomed.2018.10.401
  44. Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
    Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.
    Cerebral Cortex 29(9):3738-3751, 2019. DOI:10.1093/cercor/bhy253
  45. Tsutomu Fukuda, Yusuke Nanjo, Masahiro Fujimoto, Kenyu Yoshida, Yuko Natsui, Fumito Ishibashi, Fumiyasu Okazaki, Hideto To, Masatomo Iwao
    Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
    Bioorganic and Medicinal Chemistry 27 (2):265-277, 2019. DOI:10.1016/j.bmc.2018.11.037
  46. Miyazaki T, Chowdhury S, Yamashita T, Matsubara T, Yawo H, Yuasa H, Yamanaka A.
    Large Timescale Interrogation of Neuronal Function by Fiberless Optogenetics Using Lanthanide Micro-particles. 26(4):1033-1043.e5.
    Cell Rep. 26(4):1033-1043.e5., 2019. DOI:10.1016/j.celrep.2019.01.001
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    Liquid- and solid-like RNA granules form through specific scaffold proteins and combine into biphasic granules.
    J. Biol. Chem. 294:107149 - 107149, 2019. DOI:10.1074/jbc.RA118.005423
  48. M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T,Oike Y.
    Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice.
    Circ J. 2019 Jan 25;83(2):368-378, 2019. DOI:10.1253/circj.CJ-18-0925
  49. Kawahara I, Goto K, Kodama K, Luo Y, Fujiwara-Tani R, Mori T, Miyagawa Y, Tanaka H, Kodama H, Hirayama A, Hosoito N, Taniguchi Y, Miki Y, Kuniyasu H
    Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle.
    Pathobiology 86:254-262, 2019. DOI:10.1159/000501524
  50. Iwatani Y, Ogawa, H, Shidara H, Sakura M, Sato T, Hojo MK, Honma A, Tsurui K
    Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals.
    Advanced Robotics :in press, 2019.
  51. Ueno T, Kaomatsu M
    Measuring Nonselective and Selective Autophagy in the Liver.
    Methods Mol Biol. 1880, 2019. DOI:10.1007/978-1-4939-8873-0_34
  52. Keisuke Iida, Yamato Tsushima, Yue Ma, Shadi Sedghi Masoud, Mai Sakuma, Tomomi Yokoyama, Wataru Yoshida, Kazunari Ikebukuro, Kazuo Nagasawa
    Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole.
    Bioorg. Med. Chem. 27:1742-1746, 2019. DOI:10.1016/j.bmc.2019.02.056
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    Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus.
    Mol Brain 12:13, 2019. DOI:10.1186/s13041-019-0431-x
  54. Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H.
    mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model.
    Pharmacol Biochem Behav.? 176:1-5, 2019. DOI:10.1016/j.pbb.2018.11.003
  55. Park S, Nayantai E, Komatsu T, Hayashi H, Mori R, Shimokawa I
    NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning.
    J Gerontol A Biol Sci Med Sci. :in press, 2019. DOI:10.1093/gerona/gly282
  56. Hosoda, H., *Kida, S
    NSP-C contributes to the upregulation of CLOCK/BMAL1-mediated transcription.
    Cytotechnology 71:453-460, 2019. DOI:10.1007/s10616-018-0266-9
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    Opposing roles of dopamine receptor D1- and D2-expressing neurons in the anteromedial olfactory tubercle in acquisition of place preference in mice.
    Front Behav Neurosci 13:50, 2019. DOI:10.3389/fnbeh.2019.00050
  58. Liu Y, Ohshiro T, Sakuragi S, Koizumi K, Mushiake H, Ishizuka T, Yawo H.
    Optogenetic study of the response interaction among multi-afferent inputs in the barrel cortex of rats.
    Sci Rep. 9(1):3917, 2019. DOI:10.1038/s41598-019-40688-2
  59. Ghandour K#,?Ohkawa N#,*, Fung CCA#, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, Nishizono H, Matsuo M, Osanai M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Kitamura T, Fukai T, Inokuchi K*?(#Equally contributed,?*Corresponding authors)
    Orchestrated ensemble activities constitute a hippocampal memory engram.
    Nature Communications 10(1):2637, 2019. DOI:10.1038/s41467-019-10683-2
  60. Nagase, M., Mikami, K., and Watabe, A.M.# (#責任著者)
    Parabrachial-to-amygdala control of aversive learning.
    Current Opinion in Behavioral Sciences :in press, 2019.
  61. Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T
    Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation deficient mice.
    Neuropsychopharmacology Reports 39:61-66, 2019. DOI:10.1002/npr2.12044
  62. Okada, K., Araki, M., Sakashita, T., Ma, B., Kanda, R., Yanagitani, N., Horiike, A., Koike, S., Oh-Hara, T., Watanabe, K., Tamai, K., Maemondo, M., Nishio, M., Ishikawa, T., Okuno, Y., Fujita, N. and *Katayama, R.
    Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance.
    EBioMedicine 41:105-119, 2019. DOI:10.1016/j.ebiom.2019.01.019
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    Prefrontal-Enriched SLIT1 Expression in Primate Cortex and its Alteration during Cortical Development.
    Japanese Journal of Biological Psychiatry 30(2):in press, 2019.
  64. Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
    Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning.
    Neurochem Int 126:11-18, 2019. DOI:10.1016/j.neuint.2019.02.011
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    Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells.
    JCI Insight 4:pii-125138, 2019. DOI:10.1172/jci.insight.125138
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    Quinidine therapy and therapeutic drug monitoring in four patients with KCNT1 mutations.
    Epileptic Disorders 21(1):48-54, 2019. DOI:10.1684/epd.2019.1026
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    Ras activation in retinal progenitor cells induces tumor formation in the eye.
    Exp. Eye Res. 180:39-42, 2019. DOI:10.1016/j.exer.2018.11.025
  68. Ikuma Kato, Mitsuko Furuya, Masaya Baba, Yoichi Kameda, Masanori Yasuda, Koshiro Nishimoto, Masafumi Oyama, Toshinari Yamasaki, Osamu Ogawa, Hitoshi Niino, Noboru Nakaigawa, Yuta Yano, Kazumasa Sakamoto, Yoji Urata, Kazuya Mikami, Shigetaka Yamasaki, Reiko Tanaka, Toshio Takagi, Tsunenori Kondo, Yoji Nagashima
    RBM10‐TFE3 Renal Cell Carcinoma Characterized by Paracentric Inversion with Consistent Closely Split Signals in Break‐apart Fluorescence in situ Hybridization: Study of Ten Cases and a Literature Review.
    Histopathology 75(2):254-265, 2019. DOI:10.1111/his.13866
  69. Imanishi, T., M. Unno, W. Kobayashi, N. Yoneda, S. Matsuda, K. Ikeda, T. Hoshii, A. Hirao, K. Miyake, G. N. Barber, M. Arita, K. J. Ishii, S. Akira, and T. Saito.
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    細胞競合の生理的、病理的な役割に関する総説.
    Development, Growth and Differentiation 60:14-20, 2018. DOI:10.1111/dgd.12415
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    細胞突起形成抑制による膠芽腫治療戦略.
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    胎児期栄養は発達障害の環境要因となりうるのか.
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    超低周波電磁界の神経幹細胞に及ぼす影響評価に関する研究.
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    Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.
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2017年度

  1. Kotaki R, Kawashima M, Yamamoto Y, Higuchi H, Nagashima E, Kurosaki N, Takamatsu M, Kikuti YY, Imadome KI, Nakamura N, Kotani A.
    Dasatinib exacerbates splenomegaly of mice inoculated with Epstein-Barr virus-infected lymphoblastoid cell lines.
    Sci Rep. 10(1):4355, 2020.
  2. T. Yamada, A. Tanaka, T. Nehira, T. Nishii, T. Kikuchi
    Altercrasins A-E, decalin derivatives, from a sea-urchin-derived Alternaria sp.: isolation and structural analysis including stereochemistry.
    Marine Drugs 17:218, 2019. DOI:10.3390/md17040218
  3. T. Yamada, A. Fujii, T. Kikuchi
    New diterpenes with a fused 6-5-6-6 ring system isolated from the marine sponge-derived fungus Trichoderma harzianum.
    Marine Drugs 17:480, 2019. DOI:10.3390/md17080480
  4. Ito T, Oti T, Takanami K, Satoh K, Ueda Y, Sakamoto T, Sakamoto H.
    A sexually dimorphic peptidergic system in the lower spinal cord controlling penile function in non-human primates.
    Spinal cord 56(1):57-62, 2018. DOI:10.1038/sc.2017.105
  5. Yamada T, Imamachi N, Onoguchi-Mizutani R, Imamura K, Suzuki Y, Akimitsu N
    5'-Bromouridine IP Chase (BRIC)-Seq to Determine RNA Half-Lives.
    Methods Mol Biol 1720:1-13, 2018. DOI:10.1007/978-1-4939-7540-2_1
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    A novel ASXL1?OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.
    Leukemia 32(6):1327-1337, 2018. DOI:10.1038/s41375-018-0083-3
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    A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1.
    Eur J Pharmacology 824:99-107, 2018. DOI:10.1016/j.ejphar.2018.02.013
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    Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.
    Oncogene 37:6107-6120, 2018. DOI:10.1038/s41388-018-0179-2
  9. Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y, Muto A, Okano H,?Yamanaka A, Tawfik VL, Kuzumaki N, Navratilova E, Porreca F, *Narita M.
    Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer.
    Molecular Pain 14:1744806918756400, 2018. DOI:10.1177/1744806918756406
  10. Ueno H, Takao K, Suemitsu S, Murakami S, Kitamura N, Wani K, Okamoto M, Aoki S, Ishihara T
    Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex.
    Neurochem Int 112:59-70, 2018. DOI:10.1016/j.neuint
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    Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus.
    Frontiers in Neural Circuit 12:6, 2018. DOI:10.3389/fncir.2018.00006
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    Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes.
    Glia 66:1034-1052, 2018. DOI:10.1002/glia.23299
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    ASXL1 mutations gain a function.
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    Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.
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    Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy.
    Mol Psychiatry. 23(2):211-221, 2018. DOI:10.1038/mp.2016.187
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    CACNA1A-related early-onset encephalopathy with myoclonic epilepsy: A case report.
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    Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A.
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    Cell-type specific survey of epigenetic modifications by tandem chromatin immunoprecipitation sequencing.
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    Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability.
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    Cerebellar α6 subunit-containing GABAA receptors: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders.
    Br J Pharmacol. 175(12):2414-2427, 2018. DOI:10.1111/bph.14198
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    Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.
    Cancer Res. 78(5):1334-1346, 2018. DOI:10.1158/0008-5472.CAN-17-3303
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    Comparative analysis of palmitoylation sites of serotonin (5-HT) receptors in vertebrates.
    Neuropsychopharmacology Reports 38:75-85, 2018. DOI:10.1002/npr2.12011
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    Decreased brain pH as a shared endophenotype of psychiatric disorders.
    Neuropsychopharmacology 43:459-68, 2018. DOI:10.1038/npp.2017.167
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    Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
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    Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7?in a manner dependent on the kinase GSK-3.
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  26. Eisuke Sato, Maho Morita, Haruo Ogawa, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Satoshi ?mura, Arihiro Iwasaki and Kiyotake Suenaga
    Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ pump inhibitor from marine cyanobacteria.
    Bioorganic & Medicinal Chemistry Letters 28 (3):298-301, 2018. DOI:10.1016/j.bmcl.2017.12.050
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    Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors.
    Biochemical and Biophysical Research Communications? 496(4):1102-1108, 2018. DOI:10.1016/j.bbrc.2018.01.145
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    Epithelial Membrane Protein 3 (Emp3) Downregulates Induction and Function of Cytotoxic T Lymphocytes by Macrophages via TNF-α Production.
    Cell Immunol. 30(2):43-51, 2018. DOI:10.1016/j.cellimm.2017.12.001
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    Establishment and Analysis of a Novel Mouse Line Carrying a Conditional Knockin Allele of a Cancer-Specific FBXW7 Mutation.
    Sci Rep. 8:2021, 2018. DOI:10.1038/s41598-018-19769-1
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    Ethological and multi-behavioral analysis of learning and memory performance in laboratory rodent models.
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    Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay.
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    Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter.
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    Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex.
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    Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.
    J Exp Med.? 215(6):1729-1747, 2018. DOI:10.1084/jem.20171151
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    Expression of the long-chain fatty acid receptor GPR40 was associated with cancer progression in colorectal cancer.
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    Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system.
    Molecular Pain 14:1744806918754930, 2018. DOI:10.1177/1744806918754934
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    Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers.
    Scientific Reports 8:2291, 2018. DOI:10.1038/s41598-018-20572-1
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    GAREM1 regulates the PR interval on electrocardiograms.
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    Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency.
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    Generation of D1-1 TALEN isogenic control cell line from Dravet syndrome patient iPSCs using TALEN-mediated editing of the SCN1A gene.
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    Glycoprotein M6a as a signaling transducer in neuronal lipid rafts.
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    Growth Cone Phosphoproteomics Reveals that GAP-43 Phosphorylated by JNK Is a Marker of Axon Growth and Regeneration.
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    Brain Struct Funct 222:2359-2378, 2017. DOI:10.1007/s00429-016-1346-2
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    Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.
    JCI Insight 2(1):e89462, 2017. DOI:10.1172/jci.insight.89462
  306. Honda T, Morii M, Nakayama Y, Suzuki K, Yamaguchi N, Yamaguchi N
    v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling.
    Sci Rep. 8:1063, 2017. DOI:10.1038/s41598-018-19599-1
  307. Aonuma H., Kaneda M., Hatakeyama D., Watanabe T., Lukowiak K. and Ito E.
    Weak involvement of octopamine in aversive taste learning in a snail.
    Neurobiol. Learn. Mem. 141:189-198, 2017. DOI:10.1016/j.nlm.2017.04.010
  308. 斎藤慎一, 片村友大, 武藤雄一郎
    アジリジン,アゼチジンの環拡大反応を利用したN-ヘテロ環合成法の開発.
    有機合成化学協会誌 75:340-348, 2017. DOI:10.5059/yukigoseikyokaishi.75.340
  309. 山中章弘
    オレキシン神経活動操作による機能解明.
    睡眠医療 11(1):19-25, 2017.
  310. 設樂久志,小川宏人
    コオロギの音源定位ナビゲーション-神経行動学が迫る動物のナビゲーションメカニズム.
    生物の科学 遺伝 71:519-525, 2017.
  311. Iijima J, Kobayashi S, Kitazume S, Kizuka Y, Fujinawa R, Korekane H, Shibata T, Saitoh SI, Akashi-Takamura S, Miyake K, Miyoshi E, Taniguchi N.
    タンパク質におけるフコース修飾の意義の解析.
    Glycobiology 27(11):1006-1015, 2017. DOI:10.1093/glycob/cwx075
  312. Sato R*, Shibata T*, Tanaka Y, Kato C, Yamaguchi K, Furukawa Y, Shimizu E, Yamaguchi R, Imoto S, Miyano S, Miyake K. (* equally contributed)
    ノックアウトライブラリーを用いた分子探索.
    Int Immunol 29(8):347-355, 2017. DOI:10.1093/intimm/dxx044
  313. 河原康一、古川龍彦
    核小体によるp53制御とがん治療薬開発の新展開.
    実験医学 35:2365-2367, 2017.
  314. 山中章弘
    光遺伝学による神経科学研究の新展開.
    医学のあゆみ 262(5):491-495, 2017.
  315. 山中章弘
    光遺伝学による睡眠覚醒の制御.
    生体の科学 65(5):484-485, 2017.
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    自殺既遂者におけるテロメア長とミトコンドリアDNAコピー数の研究.
    Sci Rep. 7(1):31-76, 2017.
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    睡眠のマニピュレーション-光遺伝学、薬理遺伝学を用いた睡眠覚醒の操作.
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    Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1.
    American Journal of Physiology-Cell Physiology 311(1):C15-23, 2016. DOI:10.1152/ajpcell.00272.2015
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    軸索再生に対するGAP-43の機能解明:GAP-43 (Ser96)のリン酸化は軸索再生の分子マーカーとなる.
    新潟医学会雑誌 130(7):405-419, 2016.
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    Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs.
    EMBO Journal

2016年度

  1. Hiroshi Fukamachi, Seon-Kyu Kim, Jiwon Koh, Hye Seung Lee, Yasushi Sasaki, Kentaro Yamashita, Taketo Nishikawaji, Shu Shimada, Yoshimitsu Akiyama, Sun-ju Byeon, Dong-Hyuck Bae, Keisuke Okuno, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Hiroshi Kawachi, Kiichiro Tsuchiya, Kazuyuki Kojima, Takashi Tokino, Yoshinobu Eishi, Yong Sung Kim, Woo Ho Kim, Yasuhito Yuasa, and Shinji Tanaka
    A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors.
    Journal of Experimental & Clinical Cancer Research 38:127, 2019. DOI:10.1186/s13046-019-1121-3
  2. Kanetake T, Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, Kihara A
    Neural symptoms in a gene knockout mouse model of Sj?gren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide.
    FASEB Journal 33:928-941, 2019. DOI:10.1096/fj.201800291R
  3. Kasahara Y, Sakakibara Y, Hiratsuka T, Moriya Y, Lesch KP, Hall FS, Uhl GR, Sora I
    Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice.
    Neuropsychopharmacology Reports 39:130-133, 2019. DOI:10.1002/npr2.12049
  4. Kano T., Sato E., Ono T., Aonuma H., Matsuzaka Y. and Ishiguro A.
    A brittle star-like robot capable of immediately adapting to unexpected physical damage.
    Royal Soc. Open Sci. 4:171200, 2018. DOI:10.1098/rsos.171200
  5. Sumitani M, Nishizawa D, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
    Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain.
    Pain Medicine 19:348-354, 2018. DOI:10.1093/pm/pnx102
  6. DiRienzo, N. and Aonuma H.
    Plasticity in extended phenotype increases offspring defense despite individual variation in web structure and behavior.
    Animal Behav. 138:9ー17, 2018. DOI:10.1016/j.anbehav.2018.01.022
  7. Kai Kitamura, Hiroaki Itoh, Kaori Sakurai, Shingo Dan, Masayuki Inoue
    Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase.
    Journal of the American Chemical Society 140(38):12189-12199, 2018. DOI:10.1021/jacs.8b07339
  8. Motohiro Nozumi, Michihiro Igarashi
    Vesicular movements in the growth cone.
    Neurochemistry International 119:71-76, 2018. DOI:10.1016/j.neuint.2017.09.011
  9. Shiratori C., Suzuki N., Momohara Y., Shiraishi K., Aonuma H., and Nagayama T.
    Cyclic AMP-regulated opposing and parallel effects of serotonin and dopamine on phototaxis in the Marmorkrebs (marbled crayfish).
    Europ. J. Neurosci. 46:1863-1874, 2017. DOI:10.1111/ejn.13632
  10. Saito T, Ishii A, Sugai K, Sasaki M, Hirose S.
    A de novo missense mutation in SLC12A5 found in a compound heterozygote patient with epilepsy of infancy with migrating focal seizures.
    Clinical Genetics 92(6):654-658, 2017. DOI:10.1111/cge.13049
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    A large-scale targeted proteomics assay resource based on an in vitro human proteome.
    Nature Methods 14:251-8, 2017. DOI:10.1038/nmeth.4116
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    A novel approach to assess the ubiquitin-fold modifier 1-system in cells.
    FEBS Lett. 591:196-204, 2017. DOI:10.1002/1873-3468.12518
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    Abnormal gamma-aminobutyric acid neurotransmission in a Kcnq2 model of early onset epilepsy.
    Epilepsia 58(8):1430-1439, 2017. DOI:10.1111/epi.13807
  14. Ayumi Hashimoto, Toyohiro Sawada, Itsuki Kageyama, Kiyohisa Natsume
    Activation of the muscarinic receptors induces the transition of the epileptic discharges to beta oscillation in hippocampal slices.
    Biophysics_and Physicobiology 14:137-146, 2017. DOI:10.2142/biophysico.14.0_137
  15. *Ueno T, *Komatsu M.
    Autophagy in the liver: functions in health and disease.
    Nat Rev Gastroenterol Hepatol. 14:170-184, 2017. DOI:10.1038/nrgastro.2016.185
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    Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer.
    Nature communications 8:14768, 2017. DOI:10.1038/ncomms14768
  17. Sho Wakayama, Shigeki Kiyonaka, Itaru Arai, Wataru Kakegawa, Shinji Matsuda, Keiji Ibata, Yuri L. Nemoto, Akihiro Kusumi, Michisuke Yuzaki & Itaru Hamachi
    Chemical labeling for visualizing native AMPA receptors in live neurons.
    Nature Communications 8:e14850, 2017. DOI:10.1038/ncomms14850
  18. Ishii A, Watkins JC, Chen D, Hirose S, Hammer MF.
    Clinical implications of SCN1A missense and truncation variants in a large Japanese cohort with Dravet syndrome.
    Epilepsia 58(2):282-290, 2017. DOI:10.1111/epi.13639
  19. Jun Nakayama, Emi Ito, Jiro Fujimoto, Shinya Watanabe and Kentaro Semba
    Comparative analysis of gene regulatory networks of highly metastatic breast cancer cells established by orthotopic transplantation and intra-circulation injection.
    International Journal of Oncology 50.2:497-504, 2017. DOI:10.3892/ijo.2016.3809
  20. Nozumi M, Nakatsu F, Katoh K, *Igarashi M
    Coordinated movement of vesicles and actin bundles during nerve growth revealed by superresolution microscopy.
    Cell Rep 18:2203-2216, 2017. DOI:10.1016/j.celrep.2017.02.008
  21. Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
    Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.
    J Clin Endocrinol Metab 101(3):841-6, 2017. DOI:10.1210/jc.2015-2855
  22. Goto E, Tokunaga F.
    Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.
    Biochemical and Biophysical Research Communications 485(1):152-159, 2017. DOI:10.1016/j.bbrc.2017.02.040
  23. Gen Shiihashi, Daisuke Ito, Itaru Arai, Yuki Kobayashi, Kanehiro Hayashi, Shintaro Otsuka, Kazunori Nakajima, Michisuke Yuzaki, Shigeyoshi Itohara, Norihiro Suzuki
    Dendritic homeostasis disruption in a novel frontotemporal dementia mouse model expressing cytoplasmic fused in sarcoma.
    EBioMedicine 24:102-115, 2017. DOI:10.1016/j.ebiom.2017.09.005
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    Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation.
    Nuc.Acids.Res 2017 45:4344-58, 2017.
  25. Furuya M, Hasumi H, Baba M, Tanaka R, Iribe Y, Onishi T, Nagashima Y, Nakatani Y, Isono Y, Yao M
    Establishment and characterization of BHD-F59RSVT, an immortalized cell line derived from a renal cell carcinoma in a patient with Birt-Hogg-Dub? syndrome.
    Laboratory Investigation 97(3):343-351, 2017. DOI:10.1038/labinvest.2016.137
  26. Honda A, Ito Y, Takahashi-Niki K, Matsushita N, Nozumi M, Tabata H, Takeuchi K, *Igarashi M
    Extracellular signals induce glycoprotein M6a clustering of lipid rafts and associated signaling molecules.
    J Neurosci 37:4046-4064, 2017. DOI:10.1523/JNEUROSCI.3319-16.2017
  27. Yamauchi T., Nishiyama M., Moroishi T., Kawamura A., Nakayama KI.
    FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem-progenitor cells.
    Mol. Cell. Biol. 37:e00470-16, 2017. DOI:10.1128/MCB.00470-16
  28. Tanabe K, Shinsato Y, Furukawa T, Kita Y, Hatanaka K, Minami K, Kawahara K, Yamamoto M, Baba K, Mori S, Uchikado Y, Maemura K, Tanimoto A, Natsugoe S
    Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
    Oncotarget 8:6353-6363, 2017. DOI:10.18632/oncotarget.14087
  29. Kayama K., Watanabe S., Takafuji T., Tsuji T., Hironaka K., Matsumoto M., Nakayama KI., Enari M., Kohno T., Shiraishi K., Kiyono T., Yoshida K., Sugimoto N., Fujita M.
    GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
    EMBO Rep. 18:123-37, 2017. DOI:10.15252/embr.201642444
  30. Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue J.
    HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.
    PLoS Pathogens 13:e100162, 2017. DOI:10.1371/journal.ppat.1006162
  31. Jinshu Xu, Ueno H,Chelsea Xu, Binglai Chen, Irving Weissman, and Pin-Xian Xu.
    Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti.
    Nature Communications 8, 15046, 2017. DOI:10.1038/ncomms15046
  32. Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y.
    Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice.
    Gastroenterology 152(1):218-231.e14, 2017. DOI:10.1053/j.gastro.2016.09.018
  33. T. Hara, T. Kojima, H. Matsuzaki, T. Nakamura, E. Yoshida, Y. Fujiwara, C. Yamamoto, S. Saito, T. Kaji
    Induction of Syndecan-4 by Organic-Inorganic Hybrid Molecules with a 1,10-Phenanthroline Structure in Cultured Vascular Endothelial Cells.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18:352, 2017. DOI:10.3390/ijms18020352
  34. Numata T, Tsumoto K, Yamada K, Kurokawa T, Hirose S, Nomura H, Kawano M, Kurachi Y, Inoue R, Mori Y.
    Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing.
    Scientific Reports 7(1):9760, 2017. DOI:10.1038/s41598-017-10357-3
  35. Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Saiga K, Ohsugi H, Tokuyama Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M, and Ueno H.
    Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion.
    Scientific Reports 7, 41838, 2017. DOI:10.1038/srep41838
  36. Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Saiga K, Ohsugi H, Tokuyama Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M, and Ueno H.
    Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity.
    Scientific Reports 7, 9891, 2017. DOI:10.1038/s41598-017-09927-2
  37. Jin M, Pomp O, Shinoda T, Toba S, Torisawa T, Furuta K, Oiwa K, Yasunaga T, Kitagawa D, Matsumura S, Miyata T, Tan TT, Reversade B, Hirotsune S.
    Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.
    Sci Rep. 7:e39902, 2017. DOI:10.1038/srep39902
  38. Zamani A, Sakuragi S, Ishizuka T, Yawo H.
    Kinetic characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization.
    Biophys Physicobiol. 14:13-22, 2017. DOI:10.2142/biophysico.14.0_13
  39. Jin Cui, Maho Morita, Osamu Ohno, Tomoyuki Kimura, Toshiaki Teruya, Takumi Watanabe, Kiyotake Suenaga, and Masakatsu Shibasaki:
    Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis.
    Chemistry An Eurean Journal 23 (35):8500-8509, 2017. DOI:10.1002/chem.201701183
  40. Nakamura, Y., Yanagawa, Y., Morrison, S.F., Nakamura, K.
    Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication.
    Cell Metabolism 25:322?334, 2017. DOI:10.1016/j.cmet.2016.12.002
  41. Matsumoto A., Pasut A., Matsumoto M., Yamashita R., Fung J., Saghatelian A., Nakayama KI., Clohessy JG., Monteleone E., Pandolfi PP.
    mTORC1 and muscle regeneration are regulated by the LINC00961 encoded SPAR polypeptide.
    Nature 541:228-32, 2017. DOI:10.1038/nature21034
  42. Hayashi K, Katanosaka K, Abe M, Yamanaka A, Nosaka K, Mizumura K, *Taguchi T
    Muscular mechanical hyperalgesia after lengthening contractions in rats depends on stretch velocity and range of motion.
    European Journal of Pain 21(1):125-139, 2017. DOI:10.1002/ejp.909
  43. Misako Matsushita, Yuhki Nakatake, Itaru Arai, Keiji Ibata, Kazuhisa Kohda, Sravan Goparaju, Miyako Murakami, Miki Sakota, Nana Chikazawa-Nohtomi, Shigeru Ko, Takanori Kanai, Michisuke Yuzaki & Minoru S.H. Ko
    Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors.
    Biochemical and Biophysical Research Communications 490:296-301, 2017. DOI:10.1016/j.bbrc.2017.06.039
  44. Ishii A, Hirose S.
    New Genes for Epilepsy - Autism Comorbidity.
    Journal of Pediatric Neurology 15(3):105-114, 2017. DOI:10.1055/s-0037-1602822
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    Non-centralized and functionally localized nervous system of ophiuroids: evidence from topical anesthetic experiments.
    Biology Open 6:425-438, 2017. DOI:10.1242/bio.019836
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    Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.
    Nature 545:238-242, 2017. DOI:10.1038/nature22313
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    Progressive Brain Atrophy in Alternating Hemiplegia of Childhood.
    Movement Disorders Clinical Practice 4(3):406-411, 2017. DOI:10.1002/mdc3.12451
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    Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny.
    Genes & Nutrition , 2017. DOI:10.1186/s12263-016-0550-2
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    Rare variants of small effect size in neuronal excitability genes influence clinical outcome in Japanese cases of SCN1A truncation-positive Dravet syndrome.
    PLoS ONE 12(7):e0180485, 2017. DOI:10.1371/journal.pone.0180485
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    Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells.
    Sci Rep. 7:493, 2017. DOI:10.1038/s41598-017-00538-5
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    Reduced SHARPIN and LUBAC formation may contribute to CCl4- or acetaminophen-induced liver cirrhosis in mice.
    International Journal of Molecular Sciences 18:326, 2017. DOI:10.3390/ijms18020326
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    Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530.
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    SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth.
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    Synthesis of Lamellarins via Regioselective Assembly of 1,2-Diarylated [1]Benzopyrano[3,4-b]pyrrol-4(3H)-one Core.
    Heterocycles 95 (2):950-971, 2017. DOI:10.3987/COM-16-S(S)63
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    Synthesis of Tricyclic Benzazocines by Aza-Prins Reaction.
    Organic Letters 19(1):266-269, 2017. DOI:10.1021/acs.orglett.6b03577
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    Vagus nerve stimulation for genetic epilepsy with febrile seizures plus (GEFS+) accompanying seizures with impaired consciousness.
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    睡眠覚醒調節におけるオレキシンの役割.
    医薬ジャーナル 53(2):97-100, 2017.
  58. 辻敬一郎・井口善生
    動物心理学研究における還元・比較・発生―研究遍歴をめぐる対談をふまえて―.
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    CHD7 promotes proliferation of neural stem cells mediated by MIF.
    Molecular Brain 9(1):96, 2016. DOI:10.1186/s13041-016-0275-6
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    Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation.
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    Novel Method to Rescue a Lethal Phenotype Through Integration of Target Gene Onto the X-chromosome.
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    A Chimera Na+-Pump Rhodopsin as an Effective Optogenetic Silencer.
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    A de novo missense mutation of GABRB2 causes early myoclonic encephalopathy.
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