成果論文リスト
本支援による成果を含む論文として支援依頼者から報告があった論文を発表の新しい順に並べました。成果論文には「先端モデル動物支援」の課題番号「16H06276」を謝辞に入れることをお願いしていますが、課題番号の記載がない論文も含めています。また、前事業「生命科学系3分野（がん・ゲノム・脳）支援活動」の支援を受けた成果のうち、そちらの課題番号のみが記載されたもの（＊）も含まれています。
2018年度
- Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S. and Irie, K.
Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin.
Heterocycles 97(1):478-492, 2018. DOI:10.3987/COM-18-S(T)37 - Hirotaka Watanabe, et al.
Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells.
Cell Rep. 23:3721-3729, 2018. DOI:10.1016/j.celrep.2018.05.081 - 和田裕一, 三浦知志, 窪俊一
マンガの読みにおける状況モデルの更新.
マンガ研究 24:93-114, 2018. - Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Ichikawa J, Osada M, Satoh K, Ozaki Y, Suzuki-Inoue K.
Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis.
J Thromb Haemost 16(5):960-972, 2018. DOI:10.1111/jth.13987 - Saito M, Ichikawa J, Ando T, Schoenecker JG, Ohba T, Koyama K, Suzuki-Inoue K, Haro H.
Platelet-Derived TGF-β Induces Tissue Factor Expression via the Smad3 Pathway in Osteosarcoma Cells.
J Bone Miner Res. 33(11):2048-2058, 2018. DOI:10.1002/jbmr.3537 - Takayama Y, Ando T, Ichikawa J, Haro H
Effect of Thrombin-Induced MCP-1 and MMP-3 Production Via PAR1 Expression in Murine Intervertebral Discs.
Sci. Rep 8(1):11320, 2018. DOI:10.1038/s41598-018-29669-z - Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama S
Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells.
Sci. Rep. 8:6760, 2018. DOI:10.1038/s41598-018-25189-y - Kamijo Y, Kawahara K, Yoshinaga T, Kurata H, Arima K, Furukawa T.
A novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analyses.
Oncoscience. 5:88-98, 2018. DOI:10.18632/oncoscience.411 - Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A.
FEAT enhances INSL3 expression in testicular Leydig cells.
Genes to cells 23:952-962, 2018. DOI:10.1111/gtc.12644 - Hideaki ABE, Manabu NATSUMEDA, Yu KANEMARU, Jun WATANABE, Yoshihiro TSUKAMOTO, Masayasu OKADA, Junichi YOSHIMURA, Makoto OISHI, and Yukihiko FUJII
MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas.
Neurol Med Chir (Tokyo) 58:290-295, 2018. DOI:10.2176/nmc.ra.2018-0044 - 岡田正康, 棗田学, 河嵜麻実, 大石誠, 藤井幸彦, 五十嵐道弘
細胞突起形成抑制による膠芽腫治療戦略.
新潟県医師会報 814（1）:9-10, 2018. - Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
Neurosci Res. in press, 2018. DOI:10.1016/j.neures.2018.08.016 - Saitoh F, Hagiwara H, Wakatsuki S, Araki T.
Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency.
Neurosci Res. in press, 2018. DOI:10.1016/j.neures.2018.08.015 - Mori R, Tanaka K, Shimokawa I
Identification and functional analysis of inflammation-related miRNAs in skin wound repair.
Dev Growth Differ 60(6):306-315, 2018. DOI:10.1111/dgd.12542 - de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu To, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R
Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds.
EMBO Mol Med 10(10):e9024, 2018. DOI:10.15252/emmm.201809024 - Umehara T, Mori R, Mace K, Murase T, Abe Y, Yamamoto T, Ikematsu K
Identification of specific microRNAs in neutrophils of type 2 diabetic mice: overexpression of microRNA-129-2-3p accelerates diabetic wound healing.
Diabetes in press, 2019. - Oikawa D, Shiota M, Wanibuchi H, Tokunaga F.
Generation of rat monoclonal antibodies against a deubiquitinase, ovarian tumor domain-containing protein 1.
Monoclon Antib Immunodiagn Immunother. 37(4):180-184, 2018. DOI:10.1089/mab.2018.0023 - Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System.
SLAS Discovery 23(10):1018-1029, 2018. DOI:10.1177/2472555218793066 - Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O.
Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
Nature Commun. 9:4424, 2018. DOI:10.1038/s41467-018-06922-7 - Akatsuka S, Li GH, Toyokuni S
Superiority of rat over murine model for studies on the evolution of cancer genome.
Free Radical Research 7:1-5, 2018. DOI:10.1080/10715762.2018.1467562 - Toyokuni S
Iron Addiction with Ferroptosis-resistance in Asbestos-induced Mesothelial Carcinogenesis: Toward the Era of Mesothelioma Prevention.
Free Radical Biology & Medicine , 2019. DOI:10.1016/j.freeradbiomed.2018.10.401 - Okada K, Nishizawa K, Setogawa S, Hashimoto K, Kobayashi K.
Task-dependent function of striatal cholinergic interneurons.
Eur J Neurosci 47(10):1174-1183., 2018. DOI:10.1111/ejn.13768 - Kurihara Y, Makita Y, Kawashima M, Fujita T, Iwasaki S, and Matsui M.
Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis.
Proc Natl Acad Sci U S A. 115(30):7831-7836, 2018. DOI:10.1073/pnas.1804971115 - Taiwa K, Yokoi S, Mito M2, Fujii K, Kimura Y, Iwasaki S, Nakagawa S.
UPA-Seq: Prediction of Functional LncRNAs Using Differential Sensitivity to UV Crosslinking.
RNA 24(12):1785-1802., 2018. DOI:10.1261/rna.067611.118 - Akichika S., Hirano S., Shichino Y., Suzuki T., Nishimasu H., Ishitani R., Sugita A., Hirose Y., Iwasaki S., Nureki O., and Suzuki T.
Cap-specific terminal N6-methylation of RNA by an RNA polymerase II-associated methyltransferase.
Science , 2018. DOI:10.1126/science.aav0080 - Iwasaki S.*, Iwasaki W., Takahashi M., Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T.*, and Ingolia NT.*
The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA.
Mol. Cell 73:1–10, 2019. DOI:10.1016/j.molcel.2018.11.026 - Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
Generation of Rat Monoclonal Antibodies Specific for DZIP3.
Monoclon Antib Immunodiagn Immunother. 37:153-157, 2018. DOI:10.1089/mab.2018.0005 - Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Shimizu A.
In-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.
J Dermatol Sci. 91:35-42, 2018. DOI:10.1016/j.jdermsci.2018.03.012 - Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time- Resolved Fluorescence (HTRF)-Based Assay System.
SLAS Discov. 23:1018-1029, 2018. DOI:10.1177/2472555218793066 - Oikawa D, Shiota M, Goto E, Komakura K, Wanibuchi H, Tokunaga F.
Generation of Rat Monoclonal Antibodies against a Deubiquitinase, OTUD1.
Monoclon Antib Immunodiagn Immunother. 37:180-184, 2018. DOI:10.1089/mab.2018.0023 - Bando Y*, Sakamoto M* (Co-first and corresponding author), Kim S, Ayzenshtat I, Yuste R.
Comparative evaluation of genetically encoded voltage indicators.
Cell Rep. in press, 2019. - Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N
Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.
Int J Mol Sci. 19(6):E1811, 2018. DOI:10.3390/ijms19061811 - Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N
Forkhead box protein A1 confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.
J Cell Biochem. in press, 2018. DOI:10.1002/jcb.27551 - Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.
Oncogene in press, 2018. DOI:10.1038/s41388-018-0481-z - Kurataka Otsuka, Yusuke Yamamoto, Takahiro Ochiya
Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer.
Oncotarget 9(37):24718-24730, 2018. DOI:10.18632/oncotarget.25339 - Miyasato Y, Yoshizawa T. et al.
Sirtuin 7 deficiency ameliorates cisplatin-induced acute kidney injury through regulation of the inflammatory response.
Sci. Rep 8:5927, 2018. DOI:10.1038/s41598-018-24257-7 - Fukuda M, Yoshizawa T. et al.
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
Nat Commun 19:2833, 2018. DOI:10.1038/s41467-018-05187-4 - Yokoshima Y, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Kato R, Hozumi J, Abe H, Azuma K, Tsuchida R, Yamada Y, Japanese TR-Cancer Pain Research Group.
Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain: An exploratory study.
Neuropsychopharmacology Report in press, 2018. DOI:10.1002/npr2.12030 - Kokuda R, Watanabe R, Okuzaki D, Akamatsu H, Oneyama C.
MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression.
Genes Cells 23(8):688-701, 2018. DOI:10.1111/gtc.12610 - Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration.
Neurochem Int 119:190-198, 2018. DOI:10.1016/j.neuint.2018.01.003 - Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.
UBL3 modification influences protein sorting to small extracellular vesicles.
Nature Commun. 9:3936, 2018. DOI:10.1038/s41467-018-06197-y - Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H.
Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
Sci. Rep. 8:e14827, 2018. DOI:10.1038/s41598-018-33139-x - Okazaki S, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Kinoshita M, Inoue E, Ohmori T, Someya T, Sora I.
Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia.
Prog Neuropsychopharmacol Biol Psychiatry 83:33-41, 2018. DOI:10.1016/j.pnpbp.2018.01.001 - Kimura A, Hishimoto A, Otsuka I, Okazaki S, Boku S, Horai T, Izumi T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
Loss of chromosome Y in blood, but not in brain, of suicide completers.
PLoS One. １３（１）:e0190667, 2018. DOI:10.1371/journal.pone.0190667 - Eguchi N, Sora I, Muguruma K.
Self-organizing cortex generated from human iPSCs with combination of FGF2 and ambient oxygen.
Biochem Biophys Res Commun. 498(4):729-735, 2018. DOI:10.1016/j.bbrc.2018.03.049 - Zhang Y, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Yamamori H, Boku S, Horai T, Someya T, Ohmori T, Hashimoto R, Sora I
Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population.
J Psychiatr Res. 103:161-166, 2018. DOI:10.1016/j.jpsychires.2018.05.014 - Horai T, Hishimoto A, Otsuka I, So T, Mouri K, Shimmyo N, Boku S, Okishio N, Sora I.
A cross-sectional study exploring useful indicators for low bone mineral density in male alcoholic patients.
Neuropsychiatr Dis Treat 14:663-669, 2018. DOI:10.2147/NDT.S153360 - Yu Chen, Masahiro Takikawa, Shuichi Tsutsumi, Yoko Yamaguchi, Atsushi Okabe, Mayuna Shibata, Tatsuya Kawase, Akane Sada, Issei Ezawa, Yuhei Takano, Kisaburo Nagata, Yutaka Suzuki, Kentaro Semba, Hiroyuki Aburatani, Rieko Ohki.
PHLDA1, another PHLDA family protein that inhibits Akt.
Cancer Sci. 109:3532-3542, 2018. DOI:10.1111/cas.13796 - Nakatsumi H., Oka T., Higa T., Shirane M., Nakayama KI.
Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1.
Genes Cells 23:599-605, 2018. DOI:10.1111/gtc.12597 - Kikuchihara S, Sugio S, Tanaka KF, Watanabe T, Kano M, Yamazaki Y, Watanabe M, Ikenaka K.
Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice.
J Neurochem 147(3):344-360, 2018. DOI:10.1111/jnc.14486 - Kano M, Watanabe T, Uesaka N, Watanabe M.
Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum.
Cerebellum. 17(6):722–734, 2018. DOI:10.1007/s12311-018-0964-z - Ashida, Y., Yanagita, R. C., Kawanami, Y., Okamura, M., Dan, S. and Irie, K.
Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin.
Heterocycles in press - Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H
Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
Sci. Rep 8(1):5435, 2018. DOI:10.1038/s41598-018-23810-8 - Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H
Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo.
J Physiol Sci :Epub ahead of print, 2018. DOI:10.1007/s12576-018-0618-4 - Asano T, Igarashi H, Ishizuka T, Yawo H
Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light.
Front Neurosci. 12:561, 2018. DOI:10.3389/fnins.2018.00561 - Shen YC, Sasaki T, Matsuyama T, Yamashita T, Shichida Y, Okitsu T, Yamano Y, Wada A, Ishizuka T, Yawo H, Imamoto Y.
Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues.
Biochemistry 57（38）:5544-5556, 2018. DOI:10.1021/acs.biochem.8b00583 - Abe K, Yawo H.
Quantitative study of the somatosensory sensitization underlying cross-modal plasticity.
PLoS One. 13(12):e0208089, 2018. DOI:10.1371/journal.pone.0208089 - Tsuge M, Osaki M, Sasaki R, Hirahata M, Okada F
SK-216, a novel inhibitor of plasminogen activator inhibitor-1, suppresses lung metastasis of human osteosarcoma.
Int J Mol Sci 19(3):736, 2018. DOI:10.3390/ijms19030736 - Matsuyama S, Kage Y, Fujimoto N, Ushijima T, Tsuruda T, Kitamura K, Shiose A, Asada Y, Sumimoto H, Takeya R.
Interaction between cardiac myosin-binding protein C and formin Fhod3.
Proc Natl Acad Sci U S A. 115(19):E4386-E4395, 2018. DOI:10.1073/pnas.1716498115 - Vu HT, Kobayashi M, Hegazy AM, Tadokoro Y, Ueno M, Kasahara A, Takase Y, Nomura N, Peng H, Ito C, Ino Y, Todo T, Nakada M, Hirao A.
Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas.
Cancer Sci. 109:2497-2508, 2018. DOI:10.1111/cas.13695 - Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T.
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.
Nature Commun. 9(1):2733, 2018. DOI:10.1038/s41467-018-05085-9 - Saika M, Inoue D, Nagase R, Sato N, Tsuchiya A, Yabushita T, Kitamura T, Goyama S.
ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFb pathway genes through histone deacetylation.
Sci. Rep. 8(1):15873, 2018. DOI:10.1038/s41598-018-33881-2 - Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T
Deficiency of AMPA receptor-palmitoylation aggravates seizure susceptibility.
J Neurosci 38:10220-10235, 2018. DOI:10.1523/JNEUROSCI.1590-18.2018 - Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T
Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation deficient mice.
Neuropsychopharmacology Reports , 2018. DOI:10.1002/npr2.12044 - Nakashima C, Yamamoto K, Fujiwara-Tani R, Luo Y, Matsushima S, Fujii K, Ohmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H
Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.
Cancer Sci. 109(6):2036-2045, 2018. DOI:10.1111/cas.13594 - Sasahira T, Nishiguchi Y, Kurihara-Shimomura M, Nakashima C, Kuniyasu H, Kirita T.
NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma.
J Cancer Res Clin Oncol 144(5):875-882, 2018. DOI:10.1007/s00432-018-2612-x - Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H, Kirita T.
The multifarious functions of pyruvate kinase M2 in oral cancer cells.
Int J Mol Sci 19(10), 2018. DOI:10.3390/ijms19102907 - Matsushima-Otsuka S, Fujiwara-Tani R, Sasaki T, Ohmori H Nakashima C, Kishi S, Nishiguchi Y, Fujii K, Luo Y, Kuniyasu H
Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma.
Oncotarget 9(93):36561-36574, 2018. DOI:10.18632/oncotarget.26337 - Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Nishiguchi Y, Kishi S, Mori S, Goto K, Kondoh M, Kuniyasu H
Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer.
Oncotarget in press, 2018. - Hashimoto Y, Hata T, Tada M, Iida M, Watari A, Okada Y, Doi T, Kuniyasu H, Yagi K, Kondoh M
Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2.
Eur J Pharm Sci 117:161-167, 2018. DOI:10.1016/j.ejps.2018.02.016 - Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy.
Pathobiology in press, 2018. - Miyagawa Y, Mori T, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Ohmori H, Kawahara I, Kuniyasu H
Intake of medium-chain fatty acids induces oxidative stress and to atrophy the myocardium.
Lipids in Health and Disease 17:258, 2018. DOI:10.1186/s12944-018-0908-0 - Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, Ríos A, Kawabata M, Kimura M, Sakai Y, *Isomura Y
Area-specific modulation of functional cortical activity during block-based and trial-based proactive inhibition.
Neuroscience 388:297-316, 2018. DOI:10.1523/JNEUROSCI.1584-18.2018 - Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, *Isomura Y, *Kimura M
Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways.
Neuron 99(6):1302-1314, 2018. DOI:10.1016/j.neuron.2018.08.002 - *Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, Ríos A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y
Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.
J Neurosci , 2018. DOI:10.1523/JNEUROSCI.1584-18.2018 - Wang C, Oshima M, Sato D, Matsui H, Kubota S, Aoyama K, Nakajima-Takagi Y, Koide S, Matsubayashi J, Mochizuki-Kashio M, Nakano-Yokomizo T, Bai J, Nagao T, Kanai A, Iwama A, Sashida G.
Ezh2 loss propagates hypermethylation at T-cell differentiation-regulating genes to promote leukemic transformation.
J Clin Invest 128(9):3872-86, 2018. DOI:10.1172/JCI94645 - Aoyama K, Oshima M, Koide S, Suzuki E, Mochizuki-Kashio M, Kato Y, Tara S, Shinoda D, Hiura N, Nakajima-Takagi Y, Sashida G, Iwama A.
Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.
iScience 9:161-174, 2018. DOI:10.1016/j.isci.2018.10.008 - Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger G, Wang J, Dong Y, Zhou Y, Wang J, Wu LY, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, et al.
Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
Cancer Discovery 8(11):1438-57, 2018. DOI:10.1158/2159-8290.CD-17-1203 - Ito N., Mohammad B., A., Shah A., I., A., and *Ohta K.
Transdifferentiation of human somatic cells by ribosome.
Dev Growth Differ. 60:241-247, 2018. DOI:10.1111/dgd.12538 - Tsurumaru, H., Ito, N., Mori, K., Wakai, S., Uchiyama, T., Iino, T., Hosoyama, A., Ataku, H., Nishijima, K., Mise, M., Shimizu, A., Harada, T., Horikawa, H., Ichikawa, N., Sekigawa, T., Jinno, K., Tanikawa, S., Yamazaki, J., Sasaki, K., Yamazaki, S., Fujita, N., and *Harayama, S.
An extracellular [NiFe] hydrogenase mediating iron corrosion is encoded in a genetically unstable genomic island in Methanococcus maripaludis.
Scientific Reports 8 8:15149, 2018. DOI:10.1038/s41598-018-33541-5 - Ohta K, Aoyama E, Ahmad SAI, Ito N, Anam MB, Kubota S, Takigawa M
CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.
J Cell Commun Signal. , 2018. DOI:10.1007/s12079-018-0487-x - Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output.
Cell Rep. 25:2704-2715, 2018. DOI:10.1016/j.celrep.2018.11.016 - Tsukahara, R., Yamamoto, S., Yoshikawa, K., Gotoh, M., Tsukahara, T., Neyama, H., Ishii, S., Akahoshi, N., Yanagida, K., Sumida, H., Araki, M., Araki, K., Yamamura, K. I., Murakami-Murofushi, K., Ueda, H.
LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.
J Pharmacol.Sci. 136:93-96, 2018. DOI:10.1016/j.jphs.2018.01.001 - Sumiyoshi K, Koso H, Watanabe S.
Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma.
Cancer Sci. 109(5):1513-1523, 2018. DOI:10.1111/cas.13579 - Koso H, Nishinakamura R, Watanabe S
Sall1 regulates microglial morphology cell autonomously in the developing retina.
Adv Exp Med Biol :209-215, 2018. DOI:10.1007/978-3-319-75402-4_26 - Kawamura Y, Yamanaka K, Poh B, Kuribayashi H, Koso H, Watanabe S
The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development.
Biochem Biophys Res Commun. 503(4):3023-3030, 2018. DOI:10.1016/j.bbrc.2018.08.088 - M. Ishido*
An Overview of Development of Quantitative Neurotoxicity Testing In vitro.
J Applied Life Sci Intl. 19:2394-1103, 2018. DOI:10.9734/JALSI/2018/45377 - M. Ishido*
The temporal turning window for rat behavioral phenotypes by rotenone.
Fund. Toxicol. Sci. 5:195-202, 2018. DOI:10.2131/fts.5.195 - Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrian Marchand, Fernaldo Richtia Winnerdy, Valerie Gabelica, Anh Tuan Phan, Masato Katahira & Kazuo Nagasawa
Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound.
ChemBioChem 19:2268-2272, 2018. DOI:10.1002/cbic.201800425 - Yue Ma, Yamato Tsushima, Mai Sakuma, Shogo Sasaki, Keisuke Iida, Sachiko Okabe, Hiroyuki Seimiya, Takatsugu Hirokawa, Kazuo Nagasawa
Development of G-quadruplex ligand for selective induction of parallel-type topology.
Org. Biomol. Chem. 16:7375-7382, 2018. DOI:10.1039/C8OB01702F - Shadi Sedghi Masoud, Kazuo Nagasawa
i-Motif-binding ligand and their effects on the structure and biological functions of i-motif.
Chem. Pharm. Bull. 66:1091-1103, 2018. DOI:10.1248/cpb.c18-00720 - Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
Cancer Sci. in press, 2018. DOI:10.1111/cas.13805 - Tominaga, K., Minato, H., Murayama, T., Sasahara, A., Nishimura, T., Kiyokawa, E., Kanauchi, H., Shimizu, S., Sato, A., Nishioka, K., Tsuji, E., Yano, M., Ogawa, T., Ishii, H., Mori, M., Akashi, K., Okamoto, K., Tanabe, M., Tada, K., Tojo, A., Gotoh, N.
Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.
Proc Natl Acad Sci U S A. in press, 2018. - Tamari, K., Konno, M., Asai, A., Koseki., Jun., Hayashi, K., Kawamoto, K., Murai, N., Matsufuji, S., Isohashi, F., Satoh, T., Goto, N., Tanaka, S., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells.
Cell Death Discovery 4(104）, 2018. DOI:10.1038/s41420-018-0117-7 - Toratani, M., Konno, M., Asai, A., Koseki, J., Kawamoto, K., Tamari, K., Li, Z., Sakai, D., Kudo, T., Satoh, T., Sato, K., Motooka, D., Okuzaki, D., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
A Convolutional Neural Network Uses Microscopic Images to Differentiate between Mouse and Human Cell Lines and Their Radioresistant Clones.
Cancer Res 78, 2018. DOI:10.1158/0008-5472.CAN-18-0653 - Toshiyama, R., Konno, M., Eguchi, H., Takemoto, H., Noda, T., Asai, A., Koseki, J., Haraguchi, N., Ueda, Y. Matsushita, K., Asukai, K., Ohashi, T., Iwagami, Y., Yamada, D., Sakai, D., Asaoka, T., Kudo, T., Kawamoto, K., Gotoh, K., Kobayashi, S., Satoh, T., Doki, Y., Nishiyama, N., Mori, M.
Poly(ethylene glycol)–poly(lysine) block copolymer–ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.
Oncogene , 2018. DOI:10.1038/s41388-018-0406-x - Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
J Clin Invest 128(12):5603-5619, 2018. DOI:10.1172/JCI121679 - Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.
Cerebral Cortex in press, 2018. DOI:10.1093/cercor/bhy253 - Ida-Yonemochi H, Morita W, Sugiura N, Kawakami R, Morioka Y, Takeuchi Y, Sato T, Shibata S, Watanabe H, Imamura T, Igarashi M, Ohshima H, Takeuchi K
Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.
Sci. Rep 8:17134-, 2018. DOI:10.1038/s41598-018-35412-5 - Yukawa T, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi, M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa S, Takeuchi R, Takahashi H, Kakita A, Someya T, *Nawa H
Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia.
Psychiarty Res 270:940-946, 2018. DOI:10.1016/j.psychres.2018.10.062 - Adhikara IM, *Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata K, Emoto N
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.
Biochem Biophys Res Commun. 509(1):89-95, 2019. DOI:10.1016/j.bbrc.2018.12.068 - Brew N, Nakamura S, Hale, N. Azhan, A., Davies, G. I., Nitsos, I., Miller, S. L., Walker, D. W., Wong, F. Y.
Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia.
Pediatr Res 83(3):442-450, 2018. DOI:10.1038/s41390-018-0045-5 - Yamauchi Y., Itoh S. et al.
HipOP mesenchymal population has high potential for repairing injured peripheral nerves.
J Cell Biochem. 119(6):4836-4844, 2018. DOI:10.1002/jcb.26684 - Takeuchi Y., Kito A. et al.
Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling.
Exp. Cell Res. 371(2):417-425, 2018. DOI:10.1016/j.yexcr.2018.09.002 - Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR.
Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.
Cell Rep. 24:2196-2210, 2018. DOI:10.1016/j.celrep.2018.07.056 - Shiori Miura, Yoshitaka Maeda, Jun Miyamoto, Ena Nakatsukasa, Nobuyoshi Fujisawa, Miki Miwa, Katsuki Nakamura, Kenji Sakimura and Toshikuni Sasaoka
Generation of functional oocytes of common marmoset by xeno-transplantation of ovarian tissue.
Proceedings of International Symposium on Animal Production and Conservation for Sustainable Development 2018 :31-33, 2018. - Michael S Nahorski, Sateesh Maddirevula, Ryosuke Ishimura, Saud Alsahli, Angela Brady, Anaïs Begemann, Tsunehiro Mizushima, Francisco J. Guzmán-Vega, Miki Obata, Yoshinobu Ichimura, Hessa S Alsaif, Shams Anazi, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Dorota Monies, Mohamed Abouelhoda, Brian F Meyer, Majid Alfadhel, Wafa Eyaid, Markus Zweier Katharina Steindl, Anita Rauch, Stefan T. Arold, *C Geoffrey Woods, *Masaaki Komatsu, *Fowzan S Alkuraya.
Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.
Brain 141:1934-1945, 2018. DOI:10.1093/brain/awy135 - Ichimura Y, Komatsu M.
Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.
Front Oncol. 8, 2018. DOI:10.3389/fonc.2018.00210 - Zhou L, Hossain MI, Yamazaki M, Abe M, Natsume R, Konno K, Kageyama S, Komatsu M, Watanabe M, Sakimura K, Takebayashi H.
Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype.
J Neurochem. 147:557-572, 2018. DOI:10.1111/jnc.14591 - Sánchez-Martín P, Komatsu M.
p62/SQSTM1 - steering the cell through health and disease.
J Cell Sci. 131, 2018. DOI:10.1242/jcs.222836 - Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Nameta M, Zhang L, Iwakura Y, Nawa H, Higuchi M, Komatsu M, Fujii M.
USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis.
iScience. 9:433-450, 2018. DOI:10.1016/j.isci.2018.11.006 - Sánchez-Martín P, Saito T, Komatsu M.
p62/SQSTM1: 'Jack of all trades' in health and cancer.
FEBS J. , 2018. DOI:10.1111/febs.14712 - Someya, M. and Ogawa, H.
Multisensory enhancement of burst activity in an insect auditory neuron.
J Neurophysiol. 120:139-148., 2018. DOI:10.1152/jn.00798.2017 - Iwatani Y, Ogawa, H, Shidara H, Sakura M, Sato T, Hojo MK, Honma A, Tsurui K
Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals.
Advanced Robotics in press, 2019. - Tatsunori Nishimura, Asuka Nakata, Xiaoxi Chen, Kurumi Nishi, Makiko Meguro-Horike, Soichiro Sasaki, Kenji Kita, Shin-ichi Horike, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Takahiko Murayama, Susumu Kohno, Chiaki Takahashi, Naofumi Mukaida, Seiji Yano, Tomoyoshi Soga, Arinobu Tojo, Noriko Gotoh
Mthfd2の研究.
Oncogene in press, 2018. DOI:10.1038/s41388-018-0589-1 - Ng IK, Lee J, Ng C, Kosmo B, Chiu L, Seah E, Mok MMH, Tan K, Osato M, Chng WJ, Yan B, Tan LK.
Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation.
Biomark Res. 6:16, 2018. DOI:10.1186/s40364-018-0130-2 - Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
Systematic review of pre-clinical chronic myeloid leukaemia.
Int J Hematol. 108(5):465-484, 2018. DOI:10.1007/s12185-018-2528-x - Koide H, Shiga A, Komai E, Yamato A, Fujimoto M, Tamura A, Kono T, Nakayama A, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Suzuki S, Takeda Y, Shibuya M, Nishioka H, Yamada S, Inoshita N, Ishiwatari N, Horiguchi K, Yokote K, Tanaka T.
Prednisolone-responsive Postpartum IgG4-related Hypophysitis.
Intern Med. 57(3):367-375, 2018. DOI:10.2169/internalmedicine.8446-16 - Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women: Chiba bone survey.
Endocr J. 65(2):193-202, 2018. DOI:10.1507/endocrj.EJ17-0331 - Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Miyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T.
Glucagonoma With Necrolytic Migratory Erythema: Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.
J Clin Endocrinol Metab. 103(7):2417-2423, 2018. DOI:10.1210/jc.2017-02646 - Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi Y, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T.
p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells.
Proc Natl Acad Sci U S A. 115(33):8370-8375, 2018. DOI:10.1073/pnas.1804243115 - Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
Resting-state functional connectivity analysis of the mouse brain using intrinsic optical signal imaging of cerebral blood volume dynamics.
Physiological Measurement 39:054003, 2018. DOI:10.1088/1361-6579/aac033 - 外川 龍之介, 奥畑 大悟, 吉田 侑冬，中尾 光之, 片山 統裕
眼位・瞳孔径変動を考慮した内因性光信号イメージングに基づく覚醒時マウス脳視野地図の推定.
生体医工学 in press, 2018. - Maeda A, Nishino T, Matsuzaki R, Yokoyama A, Suga H, Yagi T, Konishi H.
Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling.
Biochim Biophys Acta Mol Cell Res. 1866:285-295, 2018. DOI:10.1016/j.bbamcr.2018.11.009 - Kikuchi K, Kozuka-Hata H, Oyama M, Seiki M & Koshikawa N
Identification of proteolytic cleavage sites of EphA2 by membrane type-1 matrix metalloproteinase on the surface of cancer cells.
Methods in Molecular Biology 1731:29-37, 2018. DOI:10.1007/978-1-4939-7595-2_3 - Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ.
Study on the tumor-induced angiogenesis using mathematical models.
Cancer Sci. 109:15-23, 2018. DOI:10.1111/cas.13395 - Takahashi Y, Hamasaki M, Aoki M, Koga K, Koshikawa N, Miyamoto S, Nabeshima K.
Activated EphA2 processing by MT1-MMP is involved in malignant transformation of ovarian tumours in vivo.
Anticancer Res 38:4257-4266, 2018. DOI:10.21873/anticanres.12722 - Okumura K, Saito M, and Wakabayashi Y.
The role of PTH in mouse skin tumorigenesis.
Integrative Cancer Science and Therapeutics 5:2, 2018. DOI:10.15761/ICST.1000271 - Aoto Y, Okumura K, Hachiya T, Hase S, Sato K, Wakabayashi Y, Ishikawa F and Sakakibara Y.
Prospective study of the tumorigenesis process with an experimental carcinogenesis model.
Sci. Rep. 8(1):12994, 2018. DOI:10.1038/s41598-018-31349-x - Huizi Li, Aya Sugyo, Atsushi Tsuji, Yukie Morokoshi, Katsuyuki Minegishi, Kotaro Nagatsu, Hiroaki Kanda, Yosuke Harada, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Tatsuya Higashi, Sumitaka Hasegawa
α-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibody against frizzled homolog 10.
Cancer Sci. 109(7):2302-2309, 2018. DOI:10.1111/cas.13636 - Noguchi K, Konno M, Eguchi H, Kawamoto K, Mukai R, Nishida N, Koseki J, Wada H, Akita H, Satoh T, Marubashi S, Nagano H, Doki Y, Mori M, Ishii H.
c-Met affects gemcitabine resistance during carcinogenesis in a mouse model of pancreatic cancer.
Oncol Lett 16(2):1892-1898, 2018. DOI:10.3892/ol.2018.8793 - Takeuchi E, Ito-Ishida A, Yuzaki M, Yanagihara D.
Improvement of cerebellar ataxic gait by injecting Cbln1 into the cerebellum of cbln1-null mice.
Sci. Rep. 8(1):6184, 2018. DOI:10.1038/s41598-018-24490-0 - Ito-Ishida A, Yamalanchili HK, Shao Y, Baker SA, Heckman LD, Lavery LA, Kim JY, Lombardi LM, Sun Y, Liu Z, Zoghbi HY.
Genome-wide distribution of linker histone H1.0 is independent of MeCP2.
Nature Neuroscience 21(6):794-798, 2018. DOI:10.1038/s41593-018-0155-8 - Aoto Y, Okumura K, Hachiya T, Hase S, Wakabayashi Y, Ishikawa F, Sakakibara Y.
Time-Series Analysis of Tumorigenesis in a Murine Skin Carcinogenesis Model.
Sci. Rep. 8(1):12994, 2018. DOI:10.1038/s41598-018-31349-x - Zhang Y, Nakano D, Guan Y, Hitomi H, Masaki T, Kobara H, Sugaya Y, Nishiyama A.
A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice.
Kidney Int. 94(3):524-535., 2018. DOI:10.1016/j.kint.2018.05.002 - Miyazawa, Y., Takahashi, Y., Watabe, A.M. and Kato F.
Predominant synaptic potentiation and activation of the right central amygdala are independent of bilateral paracrachial activation in the hemilateral trigeminal inflammatory pain model of rats.
Molecular Pain :14:1744806918807102, 2018. DOI:10.1177/1744806918807102 - Nagase, M., Mikami, K., and Watabe, A.M.# (#責任著者)
Parabrachial-to-amygdala control of aversive learning.
Current Opinion in Behavioral Sciences in press, 2019. - Futakuchi M, Nitanda T, Ando S, Matsumoto H, Yoshimoto E, Fukamachi K, Suzui M
Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment.
Int J Mol Sci 19（3）, 2018. DOI:10.3390/ijms19030888 - Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H
Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes.
Chem Res Toxicol 31（10）:1025-1031, 2018. DOI:10.1021/acs.chemrestox.8b00067 - Jinnai, W. Nakamura, S. Koyano, K. Yamato, S. Wakabayashi, T. Htun, Y. Nakao, Y. Iwase, T. Nakamura, M. Yasuda, S. Ueno, M. Miki, T.Kusaka T
Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglets.
Brain Dev 40(8):649-661, 2018. DOI:10.1016/j.braindev.2018.04.010
2017年度
- Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI.
Thymidine Catabolism as a Metabolic Strategy for Cancer Survival.
Cell Rep. 19:1313-1321, 2017. DOI:10.1016/j.celrep.2017.04.061 - Furukawa T, Tabata S, Yamamoto M, Kawahara K, Shinsato Y, Minami K, Shimokawa M, Akiyama SI
Thymidine phosphorylase in cancer aggressiveness and chemoresistance.
Pharmacol Research 132:15-20, 2018. DOI:10.1016/j.phrs.2018.03.019 - 河原康一、古川龍彦
核小体によるp53制御とがん治療薬開発の新展開.
実験医学 35:2365-2367, 2017. - Yuichiro Yoneoka, Junichi Yoshimura, Masayasu Okada, Yukihiko Fujii:
Perifocal Inflammatory Reaction with Volume Fluctuation Caused by Diagnostic Radiation-Induced Reduction in Germinoma Makes Histological Diagnosis Difficult despite Its Disappearance following Treatment: A Significant Pitfall and Countermeasures to It.
Pediatr Neurosurg. 52:87-92, 2017. DOI:10.1159/000450583 - Yuichiro Yoneoka, Junichi Yoshimura, Masakazu Sano, Masayasu Okada, Akiyoshi Kakita, Yukihiko Fujii
Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement.
Pediatr Neurosurg. 53(1):49-54, 2017. DOI:10.1159/000480021 - Hideko Ohno, Yuichiro Yoneoka, Shinya Jinguji, Naoto Watanabe, Masayasu Okada, Yukihiko Fujii
Has acromegaly been diagnosed earlier?.
J Clin Neurosci. 48:138-142, 2017. DOI:10.1016/j.jocn.2017.10.086 - Yuichiro Yoneoka, Masayasu Okada, Naoto Watanabe, Satoru Aoki, Akiyoshi Kakita, Yukihiko Fujii
Ectopic pituitary null cell adenoma arising from the infundibulum in the third ventricle: A successful endonasal transsphenoidal resection after long-term follow-up MR imaging – A technical note.
Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 10:122-125, 2017. DOI:10.1016/j.inat.2017.08.004 - Manabu Natsumeda, Kunio Motohashi, Hironaka Igarashi, Takanori Nozawa, Hideaki Abe, Yoshihiro Tsukamoto, Ryosuke Ogura, Masayasu Okada, Tsutomu Kobayashi, Hiroshi Aoki, Hitoshi Takahashi, Akiyoshi Kakita, Koichiro Okamoto, Tsutomu Nakada, Yukihiko Fujii
Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy.
Neurosurg Rev 41（2）:641-647, 2018. DOI:10.1007/s10143-017-0908-y - Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K*.
Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Exp Neurol 293:1-12, 2017. DOI:10.1016/j.expneurol.2017.03.009 - Park S, Mori R, Shimokawa I
The fat regulator neuropeptide Y and caloric restriction.
Aging (Albany NY) 9(11):2243-2244, 2017. DOI:10.18632/aging.101338 - Hattori M, Shimizu A, Oikawa D, Kamei K, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Tokunaga F, Ishikawa O.
Endoplasmic reticulum stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa.
British Journal of Dermatology 177(4):e92-e93, 2017. DOI:10.1111/bjd.15342 - Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S.
Iron and thiol redox signaling in cancer.
Free Radical Biology & Medicine 108:610-626, 2017. DOI:10.1016/j.freeradbiomed.2017.04.024 - Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon S, Fulda S, Gascon S, Hatzios SK, Kagan V, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat G, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti F, Torti S, Toyokuni S, Woerpel KA, Zhang DD.
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease.
Cell 171:273-285, 2017. DOI:10.1016/j.cell.2017.09.021 - Asami Kawasak, Masayasu Okada, Atsushi Tamada, Shujiro Okuda, Motohiro Nozumi, Yasuyuki Ito, Daiki Kobayashi, Tokiwa Yamasaki, Ryo Yokoyama, Takeshi Shibata, Hiroshi Nishina, Yutaka Yoshida, Yukihiko Fujii, Kosei Takeuchi, Michihiro Igarashi
Growth Cone Phosphoproteomics Reveals that GAP-43 Phosphorylated by JNK Is a Marker of Axon Growth and Regeneration.
iScience 4:190-203, 2018. DOI:10.1016/j.isci.2018.05.019 - Michihiro Igarashi, Motohiro Nozumi, Ling-Gang Wu, Francesca Cella Zanacchi, István Katona, László Barna, Pingyong Xu, Mingshu Zhang, Fudong Xue and Edward Boyden
New observations in neuroscience using superresolution microscopy.
J Neurosci 38(44):9459-9467, 2018. DOI:10.1523/JNEUROSCI.1678-18.2018 - 井口善生
オペラント条件づけ―基礎理論を学ぶ.
臨床心理学 (もっと知りたいあなたのための認知行動療法ガイド) 18:7-11, 2018. - Arakawa, H., & Iguchi, Y.
Ethological and multi-behavioral analysis of learning and memory performance in laboratory rodent models.
Neurosci Res. 135:1-12, 2018. DOI:10.1016/j.neures.2018.02.001 - Lucas BA, Lavi E, Shiue L, Cho H, Katzman S, Miyoshi K, Siomi MC, Carmel L, Ares M Jr, Maquat LE.
Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay.
Proc Natl Acad Sci U S A. 115:968-973, 2018. DOI:10.1073/pnas.1715531115 - Nishida KM, Sakakibara K, Iwasaki YW, Yamada H, Murakami R, Murota Y, Kawamura T, Kodama T, Siomi H, Siomi MC.
Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis.
Nature 555:260-264, 2018. DOI:10.1038/nature25788 - Mito M., Kadota M., Tanaka K., Furuta Y., Abe K., Iwasaki S.*, and Nakagawa S.
Cell-type specific survey of epigenetic modifications by tandem chromatin immunoprecipitation sequencing.
Sci. Rep. 8:1143, 2018. DOI:10.1038/s41598-018-19494-9 - Naruse K., Matsuura-Suzuki E., Watanabe M., Iwasaki S.*, Tomari Y.
In vitro reconstitution of chaperone-mediated human RISC assembly.
RNA 24(1):6-11, 2018. DOI:10.1261/rna.063891.117 - Kuriyama Y, Hattori M, Mitsui T, Nakano H, Oikawa D, Tokunaga F, Ishikawa O, Shimizu A.
Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency.
J Dermatol. 45:e108-e109, 2018. DOI:10.1111/1346-8138.14149 - Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H
Calmodulin kinases: essential regulators in health and disease.
J Neurochem. 141(6):808-818, 2017. DOI:10.1111/jnc.14020 - Kwon T*, Sakamoto M* (Co-first author), Peterka DS, Yuste R
Attenuation of Synaptic Potentials in Dendritc Spines.
Cell Rep. 20(5):1100-1110, 2017. DOI:10.1016/j.celrep.2017.07.012 - Yamaguchi N, Nakayama Y, Yamaguchi N
Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6.
J Biol Chem. 292(20):8136-8148, 2017. DOI:10.1074/jbc.M116.763276 - Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N
Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).
Biochem Biophys Res Commun. 490(3):1045-1051, 2017. DOI:10.1016/j.bbrc.2017.06.163 - Anzai E, Hirata K, Shibazaki M, Yamada C, Morii M, Honda T, Yamaguchi N, Yamaguchi N
FOXA1 Induces E-Cadherin Expression at the Protein Level via Suppression of Slug in Epithelial Breast Cancer Cells.
Biol Pharm Bull. 40(9):1483-1489, 2017. DOI:10.1248/bpb.b17-00307 - Takakura Y, Yamaguchi N, Honda T, Morii M, Yuki R, Nakayama Y, Yamaguchi N
The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALK(ATI)) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner.
Biol Pharm Bull. 40(11):1968-1975, 2017. DOI:10.1248/bpb.b17-00548 - Honda T, Morii M, Nakayama Y, Suzuki K, Yamaguchi N, Yamaguchi N
v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling.
Sci. Rep 8:1063, 2017. DOI:10.1038/s41598-018-19599-1 - Okamoto A, Morinaga T, Yamaguchi N, Yamaguchi N
Golgi Distribution of Lyn to Caveolin- and Giantin-Positive cis-Golgi Membranes and the Caveolin-Negative, TGN46-Positive trans-Golgi Network.
Biol Pharm Bull. 41(1):142-146, 2017. DOI:10.1248/bpb.b17-00681 - Hozumi J, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Kusakabe Y, Yamada Y
Resistin Is a Novel Marker for Postoperative Pain Intensity.
Anesthesia & Analgesia in press, 2018. DOI:10.1213/ANE.0000000000003363 - Nakamura T, Okabe S, Yoshida H, Iida K, Ma Y, Sasaki S, Yamori T, Shin-Ya K, Nakano I, Nagasawa K, Seimiya H.
Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole.
Sci. Rep. 7:e3605, 2017. DOI:10.1038/s41598-017-03785-8 - Kawada, M., Inoue, H., Kajikawa, M., Sugiura, M., Sakamoto, S., Urano, S., Karasawa, C., Usami, I., Futakuchi, M., Masuda, T.
A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo.
Sci. Rep. 7:40400, 2017. DOI:10.1038/srep40400 - Ishisaka N, Shimano S, Miura T, Motomura K, Horii M, Imanaga H, Kishimoto J, Kaneda Y, Sora I, Kanba S.
Neurocognitive profile of euthymic Japanese patients with bipolar disorder.
Psychiatry Clin Neurosci. 71(6):373-382, 2017. DOI:10.1111/pcn.12500 - Shimmyo N, Hishimoto A, Otsuka I, Okazaki S, Boku S, Mouri K, Horai T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
Association study of MIF promoter polymorphisms with suicide completers in the Japanese population.
Neuropsychiatr Dis Treat. 13:899-908, 2017. DOI:10.2147/NDT.S130855 - Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Inoue E, Igeta H, Otsuka I, Shibuya M, Egawa J, Sora I, Someya T.
Rare FBXO18 variations and risk of schizophrenia: Whole-exome sequencing in two parent-affected offspring trios followed by resequencing and case-control studies.
Psychiatry Clin Neurosci. 71(8):562-568, 2017. DOI:10.1111/pcn.12526 - Otsuka I, Izumi T, Boku S, Kimura A, Zhang Y, Mouri K, Okazaki S, Shiroiwa K, Takahashi M, Ueno Y, Shirakawa O, Sora I, Hishimoto A.
Aberrant telomere length and mitochondrial DNA copy number in suicide completers.
Sci. Rep 7(1):3176, 2017. DOI:10.1038/s41598-017-03599-8 - Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Kaneko N, Muratake T, Shinmyo N, Otsuka I, Okuda S, Inoue E, Igeta H, Shibuya M, Egawa J, Orime N, Sora I, Someya T.
Rare PDCD11 variations are not associated with risk of schizophrenia in Japan.
Psychiatry Clin Neurosci. 71(11):780-788, 2017. DOI:10.1111/pcn.12549 - Luo H, Hasegawa K, Liu MS, Song W-J.
Comparison of the Upper Marginal Neurons of Cortical Layer 2 with Layer 2/3 Pyramidal Neurons in Mouse Temporal Cortex.
Front Neuroanat 11:115, 2017. DOI:10.3389/fnana.2017.00115 - Nishimura M, Takemoto M, Song W-J.
Organization of auditory areas in the superior temporal gyrus of marmoset monkeys revealed by real-time optical imaging.
Brain Structure and Function in press:1599-1614, 2018. DOI:10.1007/s00429-017-1574-0 - Meikui Wu,Makoto Takemoto,Huan Luo,Jian-Jun Xu,Mei-Hong Lu,Masaki Kameyama,Toru Takumi,Wen-Jie Song.
A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1.
Eur J Pharmacology 824:99-107, 2018. DOI:10.1016/j.ejphar.2018.02.013 - Ohta S, Kawakami Y, Okano H
MIF: functions in brain and glioblastoma.
Oncotarget 8(29):46706-46707, 2017. DOI:10.18632/oncotarget.18489 - Naoaki Sakata, Yohko Yamaguchi, Yu Chen, Masayuki Shimoda, Gumpei Yoshimatsu, Michiaki Unno, Shoichiro Sumi, Rieko Ohki.
Pleckstrin homology-like domain family A, member 3 (PHLDA3) deficiency improves islets engraftment through the suppression of hypoxic damage.
PLoS One. 12(11):e0187927, 2017. DOI:10.1371/journal.pone.0187927 - Yachie N., Robotic Biology Consortium (incl. Nakayama KI.), Natsume T.
Robotic crowd biology with Maholo LabDroids.
Nature Biotechnol. 35:310-2, 2017. DOI:10.1038/nbt.3758 - Zhang S., Chen Q., Liu Q., Li Y., Sun X., Hong L., Ji S., Liu C., Geng J., Zhang W., Lu Z., Yin ZY., Zeng Y., Lin KH., Wu Q., Li Q., Nakayama K., Nakayama KI., Deng X., Johnson RL., Zhu L., Gao D., Chen L., Zhou D.
Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2.
Cancer Cell 31:669-84, 2017. DOI:10.1016/j.ccell.2017.04.004 - Muto Y., Nishiyama M., Nita A., Moroishi T., Nakayama KI.
Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
Nature Commun. 8:16114, 2017. DOI:10.1038/ncomms16114 - Yaguchi H., Yabe I., Takahashi H., Watanabe M., Nomura T., Kano T., Matsumoto M., Nakayama KI., Watanabe M., Hatakeyama S.
Sez6l2 regulates phosphorylation of ADD and neuritogenesis.
Biochem Biophys Res Commun. 494:234-41, 2017. DOI:10.1016/j.bbrc.2017.10.047 - Fukushima H., Shimizu K., Watahiki A., Hoshikawa S., Kosho T., Oba D., Sakano S., Arakaki M., Yamada A., Nagashima K., Okabe K., Fukumoto S., Jimi E., Bigas A., Nakayama KI., Nakayama K., Aoki Y., Wei W., Inuzuka H.
NOTCH2 Hajdu-Cheney mutations escape SCFFBW7-dependent proteolysis to promote osteoporosis.
Mol. Cell 68:645-58.e5, 2017. DOI:10.1016/j.molcel.2017.10.018 - Yonehara R., Nada S., Nakai T., Nakai M., Kitamura A., Ogawa A., Nakatsumi H., Nakayama KI., Li S., Standley DM., Yamashita E., Nakagawa A., Okada M.
Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nature Commun. 8:1625, 2017. DOI:10.1038/s41467-017-01762-3 - Nakatsumi H., Matsumoto M., Nakayama KI.
Noncanonical pathway for regulation of CCL2 expression by an mTORC1-FOXK1 axis promotes recruitment of tumor-associated macrophages.
Cell Rep. 21:2471-86, 2017. DOI:10.1016/j.celrep.2017.11.014 - Hagihara H., Catts VS., Katayama Y., Shoji H., Takagi T., Huang FL., Nakao A., Mori Y., Huang KP., Ishii S., Graef IA., Nakayama KI., Shannon Weickert C., Miyakawa T.
Decreased brain pH as a shared endophenotype of psychiatric disorders.
Neuropsychopharmacology 43:459-68, 2018. DOI:10.1038/npp.2017.167 - Sakai E., Nakayama M., Oshima H., Kouyama Y., Niida A., Fujii S., Ochiai A., Nakayama KI., Mimori K., Suzuki Y., Hong CP., Ock CY., Kim SJ., Oshima M.
Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.
Cancer Res. in press, 2018. DOI:10.1158/0008-5472.CAN-17-3303 - Mikamo M., Kitagawa K., Sakai S., Uchida C., Ohhata T., Nishimoto K., Niida H., Suzuki S., Nakayama KI., Inui N., Suda T., Kitagawa M.
Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis.
J Mol Sci. 19in press, 2018. DOI:10.3390/ijms19020474 - Nakayama S., Yumimoto K., Kawamura A., Nakayama KI.
Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.
J Biol Chem. in press, 2018. DOI:10.1074/jbc.RA117.000741 - Matsumoto M.,. Nakayama KI
The promise of targeted proteomics for quantitative network biology.
Curr. Opin. Biotechnol. 54:88-97, 2018. DOI:10.1016/j.copbio.2018.02.014 - Hashimoto Y., Shirane M., Nakayama KI.
TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation.
Genes Cells 23(6):418-434, 2018. DOI:10.1111/gtc.12583 - Kano M, Watanabe T
Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease.
F1000Research 6:416, 2017. DOI:10.12688/f1000research.10485.1 - Aikawa T, Watanabe T, Miyazaki T, Mikuni T, Wakamori M, Sakurai M, Aizawa H, Ishizu N, Watanabe M, Kano M, Mizusawa H, Watase K.
Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice.
Human Molecular Genetics 26(16):3094-3104, 2017. DOI:10.1093/hmg/ddx193 - Watanabe T, Shimazaki T, Oda Y.
Coordinated expression of two types of low-threshold K+ channels establishes unique single-spiking of Mauthner cells among segmentally homologous neurons in the zebrafish hindbrain.
eNeuro 1523:0249-17, 2017. DOI:10.1523/ENEURO.0249-17.2017 - Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M.
Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum.
Neuron 97(4):796-805, 2018. DOI:10.1016/j.neuron.2018.01.018 - Hanaki, Y., Kikumori, M., Tokuda, H., Okamura, M., Dan, S., Adachi, N., Saito, N., Yanagita, R. C., Irie, K.
Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities.
Molecules 22(4):e631, 2017. DOI:10.3390/molecules22040631 - Katow H, Kanaya T, Ogawa T, Egawa R, Yawo H.
Regulation of axon arborization pattern in the developing chick ciliary ganglion: Possible involvement of caspase 3.
Dev Growth Differ 59(3):115-128, 2017. DOI:10.1111/dgd.12346 - Tsunoda SP, Prigge M, Abe-Yoshizumi R, Inoue K, Kozaki Y, Ishizuka T, Yawo H, Yizhar O, Kandori H.
Functional characterization of sodium-pumping rhodopsins with different pumping properties.
PLoS One. 12(7):e0179232, 2017. DOI:10.1371/journal.pone.0179232 - Asano T, Ishizuka T, Yawo H.
Myogenic Maturation by Optical-Training in Cultured Skeletal Muscle Cells.
Methods Mol Biol. 1668:135-145, 2017. DOI:10.1007/978-1-4939-7283-8_10 - Abe K, Yawo H.
Optogenetic conditioning of paradigm and pattern discrimination in the rat somatosensory system.
PLoS One. 12(12):e0189439, 2017. DOI:10.1371/journal.pone.0189439 - Tashima R, Koga K, Sekine M, Kanehisa K, Kohro Y, Tominaga K, Matsushita K, Tozaki-Saitoh H, Fukazawa Y, Inoue K, Yawo H, Furue H, Tsuda M.
Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats.
eNeuro 5(1):ENEURO.0450-17, 2018. DOI:10.1523/ENEURO.0450-17.2018 - Okitsu T, Matsuyama T, Yamashita T, Ishizuka T, Yawo H, Imamoto Y, Shichida Y, Wada A.
Alternative Formation of Red-Shifted Channelrhodopsins: Noncovalent Incorporation with Retinal-Based Enamine-Type Schiff Bases and Mutated Channelopsin.
Chem Pharm Bull (Tokyo). 28(3):1024-1038, 2017. DOI:10.1248/cpb.c17-00054 - Moriguchi S, Ishizuka T, Yabuki Y, Shioda N, Sasaki Y, Tagashira H, Yawo H, Yeh JZ, Sakagami H, Narahashi T, Fukunaga K.
Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy.
Mol Psychiatry. 23(2):211-221, 2018. DOI:10.1038/mp.2016.187 - Ushijima T, Fujimoto N, Matsuyama S, Kan-o M, Kiyonari H, Shioi G, Kage Y, Yamasaki S, Takeya R, Sumimoto H.
The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice.
J Biol Chem. 293:148-162, 2018. DOI:10.1074/jbc.M117.813931 - Tsutomu Fukuda, Minoru Komure, Gen Onodera, Masanari Kimura, Masatomo Iwao
Synthesis of 4,5-disubstituted pyrano[3,4-b]pyrrol-7(1H)-ones via Sonogashira–Hagihara cross-coupling of N-benzenesulfonyl-3-bromo-1H-pyrrole-2-carboxylate and subsequent iodine-mediated cyclization.
Heterocycles 97in press, 2018. DOI:10.3987/COM-18-S(T)68 - Ali MAE， Fuse K， Tadokoro Y， Hoshii T， Ueno M， Kobayashi M， Nomura N， Vu HT， Peng H， Hegazy AM， Masuko M， Sone H， Arai F， Tajima A， Hirao A.
Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression.
Sci. Rep. :11442, 2017. DOI:10.1038/s41598-017-11909-3 - Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi N, Hirao A
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cell Stem Cell 22:713-725, 2018. DOI:10.1016/j.stem.2018.04.002 - Goyama S and Kitamura T.
Epigenetics in Normal and Malignant Hematopoiesis: An Overview and Update 2017.
Cancer Sci. 108(4):553-562, 2017. DOI:10.1111/cas.13168 - Kitamura T.
ASXL1 mutations gain a function.
Blood 131(3):274-275, 2018. DOI:10.1182/blood-2017-12-816595 - Nagase R, Inoue D, Pastore A, Fujino T, Hou HA, Yamasaki N, Goyama S, Saika M, Kanai A, Sera Y, Horikawa S, Ota Y, Asada S, Hayashi Y, Kawabata KC, Takeda R, Tien HF, Honda H, Abdel-Wahab O, Kitamura T.
Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.
J Exp Med. 215(6):1729-1747, 2018. DOI:10.1084/jem.20171151 - Inoue D, Fujino T, Sheridan P, Zhang Yz, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata KC, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang FC, Oyama M, Kitamura T
A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.
Leukemia 32(6):1327-1337, 2018. DOI:10.1038/s41375-018-0083-3 - Itoh M, Kaizuka T, Hayashi T
Evolutionary acquisition and divergence of vertebrate HCN2 palmitoylation.
Neurotransmitter 4:e1603, 2017. DOI:10.14800/nt.1603 - Hayashi T
Conservation and phylogenetic stepwise changes of aquaporin (AQP) 4 palmitoylation in vertebrate evolution.
Neurotransmitter 4:e1608, 2017. DOI:10.14800/nt.1608 - Kaizuka T, Hayashi T
Comparative analysis of palmitoylation sites of serotonin (5-HT) receptors in vertebrates.
Neuropsychopharmacology Reports 38:75-85, 2018. DOI:10.1002/npr2.12011 - Kusuoka O, Fujiwara-Tani R, Nakashima C, Fujii K, Ohmori H, Mori T, Kishi S, Miyagawa Y, Goto K, Kawahara I, Kuniyasu H
Intermittent calorie restriction enhances epithelial-mesenchymal transition through alteration of energy metabolism in a mouse tumor model.
International Journal of Oncology 52:413-423, 2018. DOI:10.3892/ijo.2017.4229 - Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T, Kuniyasu H.
Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma.
Histopathology 70(4):539-548, 2017. DOI:10.1111/his.13097 - Kishi S, Fujiwara-Tani R, Luo Y, Kawahara I, Goto K, Fujii K, Ohmori H, Nakashima C, Sasaki T, Kuniyasu H
Pro-metastatic signaling of elaidic acid, a trans fatty acid, is associated with lipid rafts.
Oncol Lett 15:4423-4426, 2018. DOI:10.3892/ol.2018.7817 - Hashimoto Y, Fukasawa M, Kuniyasu H, Yagi K, Kondoh M
Claudin-targeted drug development using anti-claudin monoclonal antibodies to treat hepatitis and cancer.
Annals of New York Academy of Sciences 1397(1):5-16, 2017. DOI:10.1111/nyas.13337 - Fujii K, Luo Y, Nishiguchi Y, Fujiwara R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H
Pro-metastatic intracellular signaling of elaidic acid, a trans fatty acid.
Int J Oncol 50(1):85-92, 2017. DOI:10.3892/ijo.2016.3797 - Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T, Kuniyasu H
Elaidic acid, a trans fatty acid, enhances the metastasis of colorectal cancer cells.
Pathobiology 84(3):144-151, 2017. DOI:10.1159/000449205 - Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Fujiwara R, Kadochi Y, Mori S, Kuniyasu H
Fatty acids inhibit anti-cancer effect of 5-fluorouracil in mouse cancer cell lines.
Oncol Lett 14(1):681-686, 2017. DOI:10.3892/ol.2017.6190 - Mori S, Kadochi Y, Luo Y, Fujiwara-Tani R, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
Proton pump inhibitor induces-collagen expression in colonocytes is associated with collagenous colitis.
World Journal of Gastroentrology 23(9):1586-1593, 2017. DOI:10.3748/wjg.v23.i9.1586 - Kadochi Y, Mori S, Fujiwara-Tani R, Luo Y, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed proliferation of CT26 mouse colon cancer cells.
Oncol Lett 14(1):673-680, 2017. DOI:10.3892/ol.2017.6195 - Kawahara I, Mori T, Goto K, Fujii K, Ohmori H, Fujiwara-Tani R, Kuniyasu H
Fatty acids induce stemness in the stromal cells of a CT26 mouse tumor model.
Pathobiology 84(5):237-242, 2017. DOI:10.1159/000471854 - Mukai S, Oue N, Oshima T, Imai T, Sekino Y, Honma R, Sakamoto N, Sentani K, Kuniyasu H, Egi H, Tanabe K, Yoshida K, Ohdan H, Yasui W
Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer.
J. Pathol. 243(1):100-110, 2017. DOI:10.1002/path.4931 - Kurihara M, Sasahira T, Nakahiro, Nakashima C, Kuniyasu H, Kirita T
Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma.
J Clin Pathol 71(5):436-441, 2018. DOI:10.1136/jclinpath-2017-204770 - Nakashima C, Kishi S, Fujiwara-Tani R, Luo Y, Kawahara I, Goto K, Fujii K, Ohmori H, Kuniyasu H
Expression of the long-chain fatty acid receptor GPR40 was associated with cancer progression in colorectal cancer.
Oncol Lett 15(6):8641-8646, 2018. DOI:10.3892/ol.2018.8383 - Soma S, Saiki A, Yoshida J, Ríos A, Kawabata M, Sakai Y, Isomura Y
Distinct laterality in forelimb-movement representations of rat primary and secondary motor cortical neurons with intratelencephalic and pyramidal tract projections.
J Neurosci 37(45):10904-10916, 2017. DOI:10.1523/JNEUROSCI.1188-17.2017 - Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A.
Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.
Leukemia 31(4):861-871, 2017. DOI:10.1038/leu.2016.268 - Sashida G, Iwama A.
Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies.
Int J Hematol 105(1):23-30, 2017. DOI:10.1007/s12185-016-2124-x - Shah A., I., A., Mohammad B., A., Ito I., and Ohta K.
Involvement of Tsukushi in diverse developmental processes.
J Cell Commun Signal. 19:205-210, 2018. DOI:10.1007/s12079-018-0452-8 - Ito, N., Katoh, K., Kushige, H., Saito, Y., Umemoto, T., Matsuzaki, Y., Kiyonari, H., Kobayashi, D., Soga, M., Era, T., Araki, N., Furuta, Y., Suda, T., Kida, Y, and *Ohta
Ribosome incorporation into somatic cells promotes transdifferentiation towards multipotency.
Sci. Rep. 8:1634, 2018. DOI:10.1038/s41598-018-20057-1 - Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, McHugh TJ.
Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics.
Science 359:679-684, 2018. DOI:10.1126/science.aaq1144 - Hashimotodani, Y., Nasrallah, K., Jensen, K.R., Chavez, A.E., Carrera, D., and Castillo, P.E.
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Neuron 95:928-943, 2017. DOI:10.1016/j.neuron.2017.07.028 - Tanaka, K., Kim, S. E., Yano, H., Matsumoto, G., Ohuchida, R., Ishikura, Y., Araki, M., Araki, K., Park, S., Komatsu, T., Hayashi, H., Ikematsu, K., Tanaka, K., Hirano, A., Martin, P., Shimokawa, I., Mori, R.
MiR-142 is required for Staphylococcus aureus clearance at skin wound sites via small GTPase-mediated regulation of the neutrophil actin cytoskeleton.
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Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
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Blood 129(13):1811-1822, 2017. DOI:10.1182/blood-2016-08-733394 - Yeon‐Joo Kim, Daniel PS Osborn, Ji‐Young Lee, Masatake Araki, Kimi Araki, Timothy Mohun, Johanna Känsäkoski, Nina Brandstack, Hyun‐Taek Kim, Francesc Miralles, Cheol‐Hee Kim, Nigel A Brown, Hyung‐Goo Kim, Juan Pedro Martinez‐Barbera, Paris Ataliotis, Taneli Raivio, Lawrence C Layman, Soo‐Hyun Kim
WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.
EMBO reports 19:269-289, 2018. DOI:10.15252/embr.201744632 - Ito S, Koso H, Sakamoto K, Watanabe S
RNA helicase DHX15 acts as a tumour suppressor in glioma.
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Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells.
J Biol Chem 292(29):12054-12064, 2017. DOI:10.1074/jbc.M117.790568 - Suzuki-Kerr H, Baba Y, Tsuhako A, Koso H, Dekker JD, Tucker H, Kuribayashi H, Watanabe S.
Forkhead box protein P1 is essential for lens epithelium transition to the fiber cells during development but does not play roles for retinal development.
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Nature Cell Biology 19(5):530-541, 2017. DOI:10.1038/ncb3509 - M. Ishido*, J. Suzuki, Y. Masuo
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A new insight into proliferative action of bisphenol A at low-dose.
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APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.
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Mol Brain 10:47-, 2017. DOI:10.1186/s13041-017-0328-5 - Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, *Igarashi M, *Sugiyama S
Chondroitin sulfate is required for onset and offset of critical period plasticity in visual cortex.
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Front Integr Neurosci 12:3ー, 2018. DOI:10.3389/fnint.2018.00003 - Nozumi M, *Igarashi M
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Neurochem Int 119:71-76, 2018. DOI:10.1016/j.neuint.2017.09.011 - *Igarashi M, Takeuchi K, Sugiyama S
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A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling.
Oncogenesis 6:e350, 2017. DOI:10.1038/oncsis.2017.51 - Hashimoto K, Ochi H, Sunamura S, Kosaka N, Mabuchi Y, Fukuda T, Yao K, Kanda H, Ae K, Okawa A, Akazawa C, Ochiya T, Futakuchi M, Takeda S, Sato S
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Proc Natl Acad Sci U S A. 115(9):2204-2209, 2018. DOI:10.1073/pnas.1717363115 - Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabe M, Sasahara M, Fukunaga K
Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons.
Molecular Psychiatry 22 (8):1205-1222, 2017. DOI:10.1038/mp.2016.200 - Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H
Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor.
Neuroscience Letters 654:99-106, 2017. DOI:10.1016/j.neulet.2017.06.005 - Sakagami H, Katsumata O, Hara Y, Sasaoka T, Fukaya M
BRAG2a, a guanine nucleotide exchange factor for Arf6, is a component of the dystrophin-associated glycoprotein complex at the photoreceptor terminal.
Investigative Ophthalmology and Visual Science (IOVS) 58 (9):3795-3803, 2017. DOI:10.1167/iovs.17-21746 - Fukai Y, Ohsawa Y, Ohtsubo H, Nishimatsu S, Hagiwara H, Noda M, Sasaoka T, Murakami T, Sunada Y
Redundancy of matrix metalloproteinases cleaving beta-dystroglycan: Implications for the pathogenesis of sarcoglycanopathy.
Biochem Biophys Res Commun. 492 (2):199-205, 2017. DOI:10.1016/j.bbrc.2017.08.048 - Okubo T, Sato A, Okamoto H, Sato T, Sasaoka T
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Nat Microbiol. 2:17066, 2017. DOI:10.1038/nmicrobiol.2017.66 - Koike M, Shibata M, Sunabori T, Yamaguchi J, Sakimura K, Komatsu M, Tanaka K, Uchiyama Y.
Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.
Am J Pathol. 187:1586-1600, 2017. DOI:10.1016/j.ajpath.2017.02.020 - Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.
Autophagy 17:1-14, 2017. DOI:10.1080/15548627.2017.1314897 - Kim TS, Shin YH, Lee HM, Kim JK, Choe JH, Jang JC, Um S, Jin HS, Komatsu M, Cha GH, Chae HJ, Oh DC, Jo EK.
Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway.
Sci. Rep 7, 2017. DOI:10.1038/s41598-017-03477-3 - Kuma A, Komatsu M, Mizushima N.
Autophagy-monitoring and autophagy-deficient mice.
Autophagy 13:1619-1628, 2017. DOI:10.1080/15548627.2017.1343770 - Yanagisawa H, Ishii T, Endo K, Kawakami E, Nagao K, Miyashita T, Akiyama K, Watabe K, Komatsu M, Yamamoto D, Eto Y.
L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human Niemann-Pick type C disease.
Sci. Rep 7, 2017. DOI:10.1038/s41598-017-15305-9 - Mizunoe Y, Kobayashi M, Sudo Y, Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita N, Komatsu M, Higami Y.
Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.
Redox Biol. 15:115-124, 2018. DOI:10.1016/j.redox.2017.09.007 - Kageyama S, Saito T, Obata M, Koide RH, Ichimura Y, *Komatsu M.
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Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice.
Sci. Rep 8, 2018. DOI:10.1038/s41598-018-21325-w - Yamaguchi T, Suzuki T, Sato T, Takahashi A, Watanabe H, Kadowaki A, Natsui M, Inagaki H, Arakawa S, Nakaoka S, Koizumi Y, Seki S, Adachi S, Fukao A, Fujiwara T, Natsume T, Kimura A, Komatsu M, Shimizu S, Ito H, Suzuki Y, Penninger JM, Yamamoto T, Imai Y, Kuba K.
The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function.
Sci Signal. 11, 2018. DOI:10.1126/scisignal.aan3638 - Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR.
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PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.
Cancer Cell. 33:355-367, 2018. DOI:10.1016/j.ccell.2018.02.004 - Fukutomi, M. and Ogawa, H.
Crickets alter wind-elicited escape strategies depending on acoustic context.
Sci. Rep. 7:15158, 2017. DOI:10.1038/s41598-017-15276-x - Sato N, Shidara H, Ogawa H.
Post-molting development of wind-elicited escape behavior in the cricket.
J Insect Physiol. 103:36-46, 2017. DOI:10.1016/j.jinsphys.2017.10.003 - 設樂久志，小川宏人
コオロギの音源定位ナビゲーション−神経行動学が迫る動物のナビゲーションメカニズム.
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Stereotaxic Surgery for Suprachiasmatic Nucleus Lesions in Mice.
Bio-protocol 7:2346, 2017. DOI:10.21769/BioProtoc.2346 - Liau WS, Tan SH, Ngoc PCT, Wang CQ, Tergaonkar V, Feng H, Gong Z, Osato M, Look AT, Sanda T.
Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia.
Leukemia 31(8):1798-1807, 2017. DOI:10.1038/leu.2016.392 - Selvarajan V, Osato M, Nah GSS, Yan J, Chung TH, Voon DC, Ito Y, Ham MF, Salto-Tellez M, Shimizu N, Choo SN, Fan S, Chng WJ, Ng SB.
RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC.
Leukemia 31(10):2219-2227, 2017. DOI:10.1038/leu.2017.40 - Wang CQ, Mok MM, Yokomizo T, Tergaonkar V, Osato M.
Runx Family Genes in Tissue Stem Cell Dynamics.
Adv Exp Med Biol 962(-):117-138, 2017. DOI:10.1007/978-981-10-3233-2_9 - Tsukada M, Ota Y, Wilkinson AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S.
In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma.
Stem Cell Reports. 9(4):1024-1033, 2017. DOI:10.1016/j.stemcr.2017.08.010 - Marsman J, Thomas A, Osato M, O'Sullivan JM, Horsfield JA.
A DNA Contact Map for the Mouse Runx1 Gene Identifies Novel Haematopoietic Enhancers.
Sci. Rep 7(1):13347, 2017. DOI:10.1038/s41598-017-13748-8 - Yoshida A, Kitajima S, Li F, Cheng C, Takegami Y, Kohno S, Wan YS, Hayashi N, Muranaka H, Nishimoto Y, Nagatani N, Nishiuchi T, Thai TC, Suzuki S, Nakao S, Tanaka T, Hirose O, Barbie DA, Takahashi C.
MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6.
Oncotarget 8(8):13872-13885, 2017. DOI:10.18632/oncotarget.14681 - Ishihara N, Suzuki S, Tanaka S, Watanabe Y, Nagayama D, Saiki A, Tanaka T, Tatsuno I.
Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells.
Mol Med Rep. 16(4):4756-4762, 2017. DOI:10.3892/mmr.2017.7141 - Nagano H, Nakagawa Y, Ishikawa N, Watanabe Y, Miyabayashi Y, Nakayama A, Fujimoto M, Komai E, Shiga A, Tamura A, Kono T, Takiguchi T, Higuchi S, Sakuma I, Hashimoto N, Suzuki S, Koide H, Yokote K, Tanaka T.
SEVEN FAMILIAL DYSALBUMINEMIC HYPERTHYROXINEMIA CASES IN THREE UNRELATED JAPANESE FAMILIES AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ANALYSIS OF THE THYROXINE BINDING PROFILE.
Endocr Pract 23(11):1325-1332, 2017. DOI:10.4158/EP171964.OR - Takiguchi T, Koide H, Nagano H, Nakayama A, Fujimoto M, Tamura A, Komai E, Shiga A, Kono T, Higuchi S, Sakuma I, Hashimoto N, Suzuki S, Miyabayashi Y, Ishiwatari N, Horiguchi K, Nakatani Y, Yokote K, Tanaka T.
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
BMC Endocr Disord. 17(1):54-61, 2017. DOI:10.1186/s12902-017-0203-5 - Yahiro, T., Kataoka, N., Nakamura, Y., Nakamura, K.
The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation.
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Role of N-myristoylation in stability and subcellular localization of the CLPABP protein.
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GAREM1 regulates the PR interval on electrocardiograms.
J Hum Genet. 63:297-307, 2018. DOI:10.1038/s10038-017-0367-x - Honda A, Usui H, Sakimura K, Igarashi M.
Rufy3 is an adapter protein for small GTPases that activates a Rac guanine nucleotide exchange factor to control neuronal polarity.
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Glycoprotein M6a as a signaling transducer in neuronal lipid rafts.
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Serum monomeric laminin-gamma2 as a novel biomarker for hepatocellular carcinoma.
Cancer Sci. 108:1432-1439, 2017. DOI:10.1111/cas.13261 - Koshikawa N, Minegishi T, Kiyokawa H, and Seiki M
Specific detection of soluble EphA2 fragments in blood as a new biomarker for pancreatic cancer.
Cell Death Dis 8:e3134, 2017. DOI:10.1038/cddis.2017.545 - Nakagawa M, Karashima T, Kamada M, Yoshida E, Yoshimura T, Nojima M, Inoue K, Shuin T, Seiki M
Development of a fully automated chemiluminescence immunoassay for urine monomeric laminin-gamma2 as a promising diagnostic tool of non-muscle invasive bladder cancer.
BMC Biomarker Res 5:29, 2017. DOI:10.1186/s40364-017-0109-4 - Aoto Y, Hachiya T, Okumura K, Hase S, Sato K, Wakabayashi Y, and Sakakibara Y.
DEclust: A statistical approach for obtaining differential expression profiles of multiple conditions.
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CENP-R acts bilaterally as a tumor suppressor and an oncogene in the two-stage skin carcinogenesis model.
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The parathyroid hormone regulates skin tumour susceptibility in mice.
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Essential Role of Endogenous Calcitonin Gene-Related Peptide in Pain-associated Plasticity in the Central Amygdala.
European Journal of Neuroscience 46(6):2149-2160, 2017. DOI:10.1111/ejn.13662 - Nobuhiko Takai, Masatsugu Ohgami, Koichi Ando, Akiko Uzawa, Ryoichi Hirayama, Saori Nakamura, Yoshihito Ohba
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RadProc vol.2:25-29., 2017. DOI:10.21175/RadProc.2017.06 - Masatsugu Ohgami, Nobuhiko Takai , Masahiko Watanabe, Koichi Ando, Akiko Uzawa, Ryoichi Hirayama
EFFECT OF N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST ON RADIATION-INDUCED GUT INJURIES IN MICE.
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The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
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TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity.
Sci Rep 7(1):5519, 2017. DOI:10.1038/s41598-017-05736-9 - Yamaguchi N, Shibazaki M, Yamada C,Anzai E, Morii M, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N.
Tyrosine Phosphorylation of the Pioneer Transcription Factor FoxA1 Promotes Activation of Estrogen Signaling.
J Cell Biochem 118:1453-1461, 2017. DOI:10.1002/jcb.25804 - Yamaguchi N, Nakayama Y, Yamaguchi N.
Down-regulation of Forkhead Box Protein A1 (FOXA1) Leads to Cancer-stem Cell-like Properties in Tamoxifen-resistant Breast Cancer Cells through Induction of Interleukin-6.
J Biol Chem 292:8136-8148, 2017. DOI:10.1074/jbc.M116.763276 - Mori S, Kadochi Y, Luo Y, Fujiwara-Tani R, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis.
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Cell & Tissue Research 370(3):441-449, 2017. DOI:10.1007/s00441-017-2674-0
2016年度
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ATP7B expression confers multidrug resistance through drug sequestration.
Oncotarget 7:22779-90, 2016. DOI:10.18632/oncotarget.8059 - Tanabe K, Shinsato Y, Furukawa T, Kita Y, Hatanaka K, Minami K, Kawahara K, Yamamoto M, Baba K, Mori S, Uchikado Y, Maemura K, Tanimoto A, Natsugoe S
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
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Synthesis of Tricyclic Benzazocines by Aza-Prins Reaction.
Organic Letters 19(1):266-269, 2017. DOI:10.1021/acs.orglett.6b03577 - Doi H, Kitajima Y, Luo L, Yan C, Tateishi S, Ono Y, Urata Y, Goto S, Mori R, Masuzaki H, Shimokawa I, Hirano A, Li TS
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Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation.
NPJ Regen Med 1:16013, 2016. DOI:10.1038/npjregenmed.2016.13 - Park S, Komatsu T, Kim SE, Tanaka K, Hayashi H, Mori R, Shimokawa I
Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction.
Aging Cell 16(2):339-348, 2016. DOI:10.1111/acel.12558 - Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T, Yamaoka S.
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Leukemia 30(3):716-727, 2016. DOI:10.1038/leu.2015.267 - Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F.
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
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HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.
PLoS Pathogens 13:e100162, 2017. DOI:10.1371/journal.ppat.1006162 - Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H.
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Oxidative stress as an iceberg in carcinogenesis and cancer biology.
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The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy.
Pathology International 66:245-259, 2016. DOI:10.1111/pin.12396 - Motohiro Nozumi, Fubito Nakatsu, Kaoru Katoh, Michihiro Igarashi
Coordinated Movement of Vesicles and Actin Bundles during Nerve Growth Revealed by Superresolution Microscopy.
Cell Rep. 18(9):2203-2216, 2017. DOI:10.1016/j.celrep.2017.02.008 - Motohiro Nozumi, Michihiro Igarashi
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Neurochemistry International 119:71-76, 2018. DOI:10.1016/j.neuint.2017.09.011 - Kai Kitamura, Hiroaki Itoh, Kaori Sakurai, Shingo Dan, Masayuki Inoue
Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase.
Journal of the American Chemical Society 140(38):12189-12199, 2018. DOI:10.1021/jacs.8b07339 - Shibata N, Kashima M, Ishiko T, Nishimura O, Rouhana L, Misaki K, Yonemura S, Saito K, Siomi H, Siomi MC, Agata K.
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Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons.
Mol. Cell 63:p1-12, 2016. DOI:10.1016/j.molcel.2016.06.008 - Sumiyoshi T, Sato K, Yamamoto H, Iwasaki YW, Siomi H, Siomi MC.
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Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.
Genetics 204:631-644, 2016. DOI:10.1534/genetics.116.187922 - Matsumoto N, Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, Siomi MC, Nureki O.
Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA.
Cell 167:484-497, 2016. DOI:10.1016/j.cell.2016.09.002 - Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, Nureki O.
Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.
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Chemical labeling for visualizing native AMPA receptors in live neurons.
Nature Commun. 8:e14850, 2017. DOI:10.1038/ncomms14850 - Misako Matsushita, Yuhki Nakatake, Itaru Arai, Keiji Ibata, Kazuhisa Kohda, Sravan Goparaju, Miyako Murakami, Miki Sakota, Nana Chikazawa-Nohtomi, Shigeru Ko, Takanori Kanai, Michisuke Yuzaki & Minoru S.H. Ko
Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors.
Biochem Biophys Res Commun. 490:296-301, 2017. DOI:10.1016/j.bbrc.2017.06.039 - Gen Shiihashi, Daisuke Ito, Itaru Arai, Yuki Kobayashi, Kanehiro Hayashi, Shintaro Otsuka, Kazunori Nakajima, Michisuke Yuzaki, Shigeyoshi Itohara, Norihiro Suzuki
Dendritic homeostasis disruption in a novel frontotemporal dementia mouse model expressing cytoplasmic fused in sarcoma.
EBioMedicine 24:102-115, 2017. DOI:10.1016/j.ebiom.2017.09.005 - Okamoto M, Nakayama Y, Kakihana A, Yuki R, Yamaguchi N, Yamaguchi N
Fyn Accelerates M Phase Progression by Promoting the Assembly of Mitotic Spindle Microtubules.
J Cell Biochem. 117(4):610-623, 2016. DOI:10.1002/jcb.25373 - Honda T, Soeda S, Tsuda K, Yamaguchi C, Aoyama K, Morinaga T, Yuki R, Nakayama Y, Yamaguchi N, Yamaguchi N
Protective role for lipid modifications of Src-family kinases against chromosome missegregation.
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Sci. Rep 7:493, 2017. DOI:10.1038/s41598-017-00538-5 - Sumitani M, Nishizawa D, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain.
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Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment.
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Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKI pathway during neuronal polarization.
Molecular brain 9(1):8, 2016. DOI:10.1186/s13041-016-0189-3 - Ide S, Takahashi T, Takamatsu Y, Uhl GR, Niki H, Sora I, Ikeda K.
Distinct Roles of Opioid and Dopamine Systems in Lateral Hypothalamic Intracranial Self-Stimulation.
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American Journal of Physiology-Cell Physiology 311(1):C15-23, 2016. DOI:10.1152/ajpcell.00272.2015 - Tetsuhisa Otani, Yosuke Ogura, Kazuyo Misaki, Takuya Maeda, Akiyo Kimpara, Shigenobu Yonemura, Shigeo Hayashi
IKKε inhibits PKC to promote Fascin-dependent actin bundling.
Development 143:3806-3816, 2016. DOI:10.1242/dev.138495 - Yoshinori Asano, Tatsuya Kawase, Atsushi Okabe, Shuichi Tsutsumi, Hitoshi Ichikawa, Satoko Tatebe, Issay Kitabayashi, Fumio Tashiro, Hideo Namiki, Tadashi Kondo, Kentaro Semba, Hiroyuki Aburatani, Yoichi Taya, Hitoshi Nakagama and Rieko Ohki
IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.
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Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.
Rheumatology 55:1117-26, 2016. DOI:10.1093/rheumatology/kew005 - Nita A., Nishiyama M., Muto Y., Nakayama KI.
FBXL12 regulates T cell differentiation in a cell-autonomous manner.
Genes Cells 5:517-24, 2016. DOI:10.1111/gtc.12360 - Tanaka M., Shiota M., Nakao T., Uemura R., Nishi S., Ohkawa Y., Matsumoto M., Yamaguchi M., Osada-Oka M., Inagaki A., Takahashi K., Nakayama KI., Gi M., Izumi Y., Miura K., Iwao H.
Identification of low-abundance proteins in serum via the isolation of HSP72 complexes.
J Proteomics 136:214-21, 2016. DOI:10.1016/j.jprot.2016.01.008 - Hosokawa H., Tanaka T., Endo Y., Kato M., Shinoda K., Suzuki A., Motohashi S., Matsumoto M., Nakayama KI., Nakayama T.
Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.
Nature Commun. 7:11289, 2016. DOI:10.1038/ncomms11289 - Takeishi S., Nakayama KI.
To wake up cancer stem cells, or to let them sleep, that is the question.
Cancer Sci. 107:875-81, 2016. DOI:10.1111/cas.12958 - Duquesnes N., Callot C., Jeannot P., Daburon V., Nakayama KI., Manenti S., Davy A., Besson A.
p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith–Wiedemann syndrome.
J Pathol. 239:250-61, 2016. DOI:10.1002/path.4721 - Kitade S., Onoyama I., Kobayashi H., Yagi H., Yoshida S., Kato M., Tsunematsu R., Asanoma K., Sonoda K., Wake N., Hata K., Nakayama KI., Kato K.
FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors.
Cancer Sci. 107:1399-405, 2016. DOI:10.1111/cas.13026 - Katayama Y., Nishiyama M., Shoji H., Ohkawa Y., Kawamura A., Sato T., Suyama M., Takumi T., Miyakawa T., Nakayama KI.
CHD8 haploinsufficiency results in autistic-like phenotypes in mice.
Nature 537:675-9, 2016. DOI:10.1038/nature19357 - Hatano A, Matsumoto M, Nakayama KI.
Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling.
Genes Cells 21:1095-112, 2016. DOI:10.1111/gtc.12406 - Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S.
The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.
J Mol Cell Cardiol. 100:43-53, 2016. DOI:10.1016/j.yjmcc.2016.09.013 - Kayama K., Watanabe S., Takafuji T., Tsuji T., Hironaka K., Matsumoto M., Nakayama KI., Enari M., Kohno T., Shiraishi K., Kiyono T., Yoshida K., Sugimoto N., Fujita M.
GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
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A large-scale targeted proteomics assay resource based on an in vitro human proteome.
Nature Methods 14:251-8, 2017. DOI:10.1038/nmeth.4116 - Matsumoto A., Pasut A., Matsumoto M., Yamashita R., Fung J., Saghatelian A., Nakayama KI., Clohessy JG., Monteleone E., Pandolfi PP.
mTORC1 and muscle regeneration are regulated by the LINC00961 encoded SPAR polypeptide.
Nature 541:228-32, 2017. DOI:10.1038/nature21034 - Ohnishi T., Shirane M., Nakayama KI.
SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth.
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FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem-progenitor cells.
Mol. Cell. Biol. 37:e00470-16, 2017. DOI:10.1128/MCB.00470-16 - 渡邉 貴樹, 上阪 直史, 狩野 方伸
生後発達期の小脳におけるシナプス刈り込みのメカニズム.
生化学 88(5):621-629, 2016. DOI:10.14952/SEIKAGAKU.2016.880621 - Hoque MR, Ishizuka T, Inoue K, Abe-Yoshizumi R, Igarashi H, Mishima T, Kandori H, Yawo H.
A Chimera Na+-Pump Rhodopsin as an Effective Optogenetic Silencer.
PLoS One. 11(11):e0166820, 2016. DOI:10.1371/journal.pone.0166820 - Zamani A, Sakuragi S, Ishizuka T, Yawo H.
Kinetic characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization.
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Adrenergic receptor-mediated modulation of striatal firing patterns.
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Integration of Organic Electrochemical and Field-Effect Transistors for Ultraflexible, High Temporal Resolution Electrophysiology Arrays.
Adv Mater. 28(44):9722-9728, 2016. DOI:10.1002/adma.201602237 - Umeda K, Ishizuka T, Yawo H, Shoji W.
Position- and quantity-dependent responses in zebrafish turning behavior.
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A Novel Reporter Rat Strain That Conditionally Expresses the Bright Red Fluorescent Protein tdTomato.
PLoS One. 11(5):e0155687, 2016. DOI:10.1371/journal.pone.0155687 - T. Fukuda, T. Katae, I. Harada, M. Iwao
Synthesis of Lamellarins via Regioselective Assembly of 1,2-Diarylated [1]Benzopyrano[3,4-b]pyrrol-4(3H)-one Core.
Heterocycles 95 (2):950-971, 2017. DOI:10.3987/COM-16-S(S)63 - Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C, Hirao A.
Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance.
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MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.
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Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.
Experimental Hematology 44:172 -176, 2016. DOI:10.1016/j.exphem.2015.11.011 - Kitamura, T., Watanabe-Okochi, N., Enomoto, Y., Nakahara, F., Oki, T., Komeno, Y., Kato, N., Doki, N., Uchida, T., Kagiyama, Y., Togami, K., Kawabata, K.C., Nishimura, K., Hayashi, Y., Nagase, R., Saika, M., Fukushima, T., Asada, S., Fujino, T., Izawa, Y., Horikawa, S., Fukuyama, T., Tanaka, Y., Ono, R., Goyama, S., Nosaka, T., Kitaura, J., and Inoue D.
Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).
J Biol Chem. 159:17-25, 2016. DOI:10.1093/jb/mvv114 - Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, Kihara A
Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
J Biol Chem. 291(22):11676-11688, 2016. DOI:10.1074/jbc.M116.714030 - Kanetake T, Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, Kihara A
Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide.
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Evolutionarily conserved phosphorylation and palmitoylation-dependent regulation of dopamine D1-like receptors in vertebrates.
Neurotransmitter 3:e1434, 2016. DOI:10.14800/nt.1434 - Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
Large-scale analysis reveals populational contributions of cortical spike rate and synchrony to behavioral functions.
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In Vivo Spiking Dynamics of Intra- and Extratelencephalic Projection Neurons in Rat Motor Cortex.
Cerebral Cortex 28(3):1024-1038, 2017. DOI:10.1093/cercor/bhx012 - Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A.
The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.
J Exp Med 213(8):1459-1477, 2016. DOI:10.1084/jem.20151121 - Kanda M, Nagai T, Takahashi T, Liu ML, Kondou N, Naito AT, Akazawa H, Sashida G, Iwama A, Komuro I, Kobayashi Y.
Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction.
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Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation.
Biochem Biophys Res Commun. 477:801-806, 2016. DOI:10.1016/j.bbrc.2016.06.138 - Kuribayashi H, Tsuhako A, Kikuchi M, Yoshida N, Koso H, Watanabe S
Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina.
Exp. Eye Res. 152:34-42, 2016. DOI:10.1016/j.exer.2016.09.005 - Koso H, Tsuhako A, Lai CY, Baba Y, Otsu M, Ueno K, Nagasaki M, Suzuki Y, Watanabe
Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina.
Glia 64(11):2005-2024, 2016. DOI:10.1002/glia.23038 - Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T and Sumiko Watanabe S
Identification of RNA-binding protein LARP4B as a tumor suppressor in glioma.
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Extracellular signals induce glycoprotein M6a clustering of lipid rafts and associated signaling molecules.
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Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1-Cre mice.
Genesis 54(7):379-388, 2016. DOI:10.1002/dvg.22951 - Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A and Hikida T.
Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage.
Learning and Memory 23 (7):359-64, 2016. DOI:10.1101/lm.042507.116 - Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T.
Dopamine D2L receptor is required for visual discrimination learning.
Molecular Neuropsychiatry 2 (3):124-132, 2016. DOI:10.1159/000447970 - Maekawa T, Sasaoka T, Azuma S, Ichikawa T, Melrose HL, Farrer MJ, Obata F;
Leucine-rich repeat kinase 2 (LRRK2) regulates alpha-synuclein clearance in microglia.
BMC Neuroscience 17 (1):77, 2016. DOI:10.1186/s12868-016-0315-2 - Habisov, S., Huber, J., Ichimura, Y., Akutsu, M., Rogova, N., Loehr, F., McEwan, D.G., Johansen, T., Dikic, I., Doetsch, V., Komatsu, M., Rogov, V.V., *Kirkin, V.
Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.
J Biol Chem. 291:9025-9041, 2016. DOI:10.1074/jbc.M116.715474 - Yang H, Ni HM, Guo F, Ding Y, Shi YH, Lahiri P, Fröhlich LF, Rülicke T, Smole C, Schmidt VC, Zatloukal K, Cui Y, Komatsu M, Fan J, Ding WX.
Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice.
J Biol Chem. 291:18663-18674, 2016. DOI:10.1074/jbc.M116.739821 - Saito, T., Waguri, S (38人中34番目)., *Komatsu, M (38人中38番目).
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.
Nat Commun 7, 2016. DOI:10.1038/ncomms12030 - Muona, M., *Lehesjoki, AE., *Komatsu, M (28人中28番目).
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.
Am. J. Hum. Genet 99:683-694, 2016. DOI:10.1016/j.ajhg.2016.06.020 - Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A.
Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.
Elife 5, 2016. DOI:10.7554/eLife.14810 - Lee DH, Han DH, Nam KT, Park JS, Kim SH, Lee M, Kim G, Min BS, Cha BS, Lee YS, Sung SH, Jeong H, Ji HW, Lee MJ, Lee JS, Lee HY, Chun Y, Kim J, Komatsu M, Lee YH, Bae SH.
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
Free Radic Biol Med. 99:520-532, 2016. DOI:10.1016/j.freeradbiomed.2016.09.009 - Ye X, Zhou Q, Matsumoto Y, Moriyama M, Kageyama S, Komatsu M, Satoh S, Tsuchida M, Saijo Y.
Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma.
Anticancer Res. 36:6021-6029, 2016. DOI:10.21873/anticanres.11191 - *Ueno T, *Komatsu M.
Autophagy in the liver: functions in health and disease.
Nat Rev Gastroenterol Hepatol. 14:170-184, 2017. DOI:10.1038/nrgastro.2016.185 - Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, *Komatsu M.
A novel approach to assess the ubiquitin-fold modifier 1-system in cells.
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昆虫の短中距離ナビゲーションを支える神経基盤.
日本ロボット学会誌 34:685-689, 2016. DOI:10.7210/jrsj.34.685 - Kimiko Shimizu, Yodai Kobayashi, Erika Nakatsuji, Maya Yamazaki, Shigeki Shimba, Kenji Sakimura & Yoshitaka Fukada
SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory.
Nature Commun. 7:12926, 2016. DOI:10.1038/ncomms12926 - Jun J. Nakano, Kimiko Shimizu, Shigeki Shimba & Yoshitaka Fukada
SCOP/PHLPP1β in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior.
Sci. Rep. 6:33500, 2016. DOI:10.1038/srep33500 - Jayapal SR, Ang HY, Wang CQ, Bisteau X, Caldez MJ, Xuan GX, Yu W, Tergaonkar V, Osato M, Lim B, Kaldis P.
Cyclin A2 regulates erythrocyte morphology and numbers.
Cell Cycle 15(22):3070-3081, 2016. DOI:10.1053/j.gastro.2016.09.018 - Chin DW, Sakurai M, Nah GS, Du L, Jacob B, Yokomizo T, Matsumura T, Suda T, Huang G, Fu XY, Ito Y, Nakajima H, Osato M.
RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.
Blood Cancer J. 6:e379, 2016. DOI:10.1038/bcj.2015.105 - Iizuka K, Yokomizo T, Watanabe N, Tanaka Y, Osato M, Takaku T, Komatsu N.
Lack of Phenotypical and Morphological Evidences of Endothelial to Hematopoietic Transition in the Murine Embryonic Head during Hematopoietic Stem Cell Emergence.
PLoS One. 11(5):e0156427, 2016. DOI:10.1371/journal.pone.0156427 - Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y.
Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice.
Gastroenterology 152(1):218-231.e14, 2017. DOI:10.1053/j.gastro.2016.09.018 - Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.
J Clin Endocrinol Metab 101(3):841-6, 2017. DOI:10.1210/jc.2015-2855 - Hengguang Zhao, Rieger S, Abe K, Hewison M, Lisse T.
DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization.
Int. J. Mol. Sci. 17:1984, 2016. DOI:10.3390/ijms17121984 - Hadano S, Mitsui S, Pan L, Otomo A, Kubo M, Sato K, Ono S, Onodera W, Abe K, Chen X, Koike M, Uchiyama Y, Aoki M, Warabi E, Yamamoto M, Ishii T, Yanagawa T, Shang H-F, Yoshii F.
Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.
Human Molecular Genetics 25:25, 2016. DOI:10.1093/hmg/ddw180 - Motojima M, Tanimoto S, Ohtsuka M, Matsusaka T, Kume T, Abe K
Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2.
Cells Tissues Organs 201:380-389, 2016. DOI:10.1159/000445027 - Motojima M, Ogiwara S, Matsusaka T, Kim SY, Sagawa N, Abe K, Ohtsuka M.
Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system.
Mammalian genoem 27:62-69, 2016. DOI:10.1007/s00335-015-9610-y - Fuchs H, Sabrautzki S, Przemeck G, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, Östereicher M, Hans W, Abe K et al.
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.
G3・Genes| Genomes| Genetics 6:4035-4046, 2016. DOI:10.1534/g3.116.033670 - Nakamura, Y., Yanagawa, Y., Morrison, S.F., Nakamura, K.
Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication.
Cell Metabolism 25:322–334, 2017. DOI:10.1016/j.cmet.2016.12.002 - Matsunaga R, Nishino T, Yokoyama A, Nakashima A, Kikkawa U, Konishi H.
Versatile function of the circadian protein CIPC as a regulator of Erk activation.
Biochem Biophys Res Commun. :377-383, 2016. DOI:10.1016/j.bbrc.2015.11.117 - Nishino T, Matsunaga R, Jikihara H, Uchida M, Maeda A, Qi G, Abe T, Kiyonari H, Tashiro S, Inagaki-Ohara K, Shimamoto F, Konishi H.
Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.
Biochim Biophys Acta. 1861:1816-1827, 2016. DOI:10.1016/j.bbalip.2016.09.006 - Ayumi Hashimoto, Toyohiro Sawada, Itsuki Kageyama, Kiyohisa Natsume
Activation of the muscarinic receptors induces the transition of the epileptic discharges to beta oscillation in hippocampal slices.
Biophysics_and Physicobiology 14:137-146, 2017. DOI:10.2142/biophysico.14.0_137 - Watabe, A.M., Nagase, M., Hagiwara, A., Hida, Y., Tsuji, M., Ochiai, T., Kato, F., Ohtsuka, T.
SAD-B Kinase regulates presynaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory.
Journal of Neurochemistry 136(1):36-47, 2016. DOI:10.1111/jnc.13379 - Tsuji, M., Takahashi, Y., Watabe, A.M., Kato, F.
Enhanced long-term potentiation in mature rats with a history of cryptogenic infantile spasms.
Epilepsia 57(3):495-505, 2016. DOI:10.1111/epi.13315 - Sugimura, Y.K., Takahashi, Y., Watabe, A.M., Kato, F.
Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala.
Journal of Neurophysiology 115:2721-2739, 2016. DOI:10.1152/jn.00946.2015 - Nomoto, M., Ohkawa, N., Nishizono, H., Yokose, J., Suzuki, A., Matuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A.M., Kato, F., Inokuchi, K.
Cellular tagging as a neural network mechanism for behavioral tagging.
Nature Communications 7(12319):1-11, 2016. DOI:10.1038/ncomms12319 - Takamura, S., Yagi, H., Hakata, Y., Motozono, C., McMaster, SR., Masumoto, T., Fujisawa, M., Chikaishi, T., Komeda, J., Itoh, J., Umemura, M., Kyusai, A., Tomura, M., Nakayama, T., Woodland, DL., Kohlmeier, JE., Miyazawa, M.
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
J Exp Med. 213(13):3057-3073, 2016. DOI:10.1084/jem.20160938 - Tuboly E, Futakuchi M, Varga G, Erces D, Tokes T, Meszaros A, Kaszaki J, Suzui M, Imai M, Okada A, Okada N, Boros M, Okada H
C5a inhibitor protects ischemia/reperfusion injury in rat small intestine.
Microbiol Immunol 60（1）:35-46, 2016. DOI:10.1111/1348-0421.12338 - Futakuchi M, Fukamachi K, Suzui M
Heterogeneity of tumor cells in the bone microenvironment: mechanisms and therapeutic targets for bone metastasis of prostate or breast cancer.
Adv Drug Deliv Rev 99, 2016. DOI:10.1016/j.addr.2015.11.017 - Suzui M, Futakuchi M, Fukamachi K, Numano T, Abd Elgied M, Takahashi S, Ohnishi M, Omori T, Tsuruoka S, Hirose A, Kanno J, Sakamoto Y, Alexander DB, Xu J, Tsuda H
Multiwalled carbon nanotubes intratracheally instilletd into the rat lung induce development of pleural malignant mesothelioma and lung tumors.
Cancer Sci 107（7）:924-935, 2016. DOI:10.1111/cas.12954 - Escudero-Esparza A., Bartoschek M., Gialeli C., Okroj M., Owen S., Jirström K., Orimo A., Jiang WG., Pietras K., Blom AM.
Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer.
Oncotarget 7:76920-76933, 2016. DOI:10.18632/oncotarget.12729 - Mezawa, Y. and Orimo A
The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas.
Cell Tissue Res 365:675-89, 2016. DOI:10.1007/s00441-016-2471-1 - Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirström K, Pietras K, Blom AM.
Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer.
Oncogene. 235:5585-5596, 2016. DOI:10.1038/onc.2016.98 - Nakamura T, Ma Y, Iida K, Ohtake T, Seimiya H, Nagasawa K.
Design, Synthesis and Evaluation of an L-Dopa-Derived Macrocyclic Hexaoxazole (6otd) as a G-Quadruplex-Selective Ligand.
Heterocycles 92:305-315, 2016. DOI:10.3987/COM-15-13383 - Lou C, Yokoyama S, Abdelhamed S, Saiki I, Hayakawa Y.
Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells.
Oncol Lett 12:295-300, 2016. DOI:10.3892/ol.2016.4554 - Sasahira T, Kurihara M, Nishiguchi Y, Fujiwara R, Kirita T, Kuniyasu H.
NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in oral squamous cell carcinoma.
Virchows Arch 469:163-172, 2016. DOI:10.1007/s00428-016-1955-4 - Sasahira T, Nishiguchi Y, Fujiwara R, Kurihara M, Kirita T, Bosserhoff AK, Kuniyasu H.
Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression.
Oncotarget 7:26754-26764, 2016. DOI:10.18632/oncotarget.8495 - Kubo H, Shimono R*,Nakamura S, Koyano K,Jinnai W, Yamato S, Yasuda S, Nakamura M, Tanaka A, Fujii T, Kanenishi K, Chiba Y, Miki T, Kusaka T, Ueno M.
Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets.
Neonatology 111(3):203-10, 2016. DOI:10.1159/000450721 - Saito M, Okumura K, Yoshizawa Y, Munakata H, Isogai E, and Wakabayashi Y.
Meis1 is required for c-Met inhibition to suppress cell proliferation of skin squamous cell carcinoma cells.
Journal of Biosciences and medicines 4(1):53-65, 2016. DOI:10.4236/jbm.2016.47007
