成果論文リスト
本支援による成果を含む論文として支援依頼者から報告があった論文を成果が得られた年度順に並べました。成果論文には「先端モデル動物支援」の課題番号「22H04922」を謝辞に入れることをお願いしていますが、課題番号の記載がない論文も含めています。
2024年度
- Tatsuya NAKAGAWA, Chihiro EMORI, Masahito IKAWA
Trophectoderm-specific gene manipulation using adeno-associated viral vectors.
Experimental Animals :2025. DOI:10.1538/expanim.24-0165 - Neyama H, Wu Y, Nakaya Y, Kato S, Miyamichi K, Matsushita N, Mashimo T, Miyasaka Y, Dai Y, Noguchi K, Watanabe Y, Kobayashi M, Kobayashi K, Cui YL
Opioidergic activation of the descending pain inhibitory system underlies placebo analgesia.
Science Advances 11(3):2025. DOI:10.1126/sciadv.adp8494 - Tokiharu Sato, Yuka Nakamura, Kana Hoshina, Ken-ichi Inoue, Masahiko Takada, Masato Yano, Hitoshi Matsuzawa, Masaki Ueno
Scg2 drives reorganization of the corticospinal circuit with spinal premotor interneurons to recover motor function after stroke.
bioRxiv :2025. DOI:10.1101/2025.01.21.634186 - Loughran G, Andreev DE, Terenin IM, Namy O, Mikl M, Yordanova MM, McManus CJ, Firth AE, Atkins JF, Fraser CS, Ignatova Z, Iwasaki S,, et al
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR).
Nat Struct Mol Biol. 32(3);418-430:2025. DOI:10.1038/s41594-025-01492-x - Chikako Okubo, Michiko Nakamura, Masae Sato, Yuichi Shichino, Mari Mito, Yasuhiro Takashima, Shintaro Iwasaki, Kazutoshi Takahashi
Selective translation orchestrates key signaling pathways in primed pluripotency.
BioRxiv :2025. DOI:10.1101/2024.02.09.579580 - Schneider-Poetsch T, Dang Y, Iwasaki W, Arata M, Shichino Y, Mourabit AA, Moriou C, Romo D, Liu JO, Ito T, Iwasaki S, and Yoshida M
Girolline is a sequence context-selective modulator of eIF5A activity.
Nat Commun. 16(1);223:2025. DOI:10.1038/s41467-024-54838-2 - Koinuma S, Miyaji M, Akiyama S, Ito Y, Takemura H, Wada N, Igarashi M, *Nakamura T
TC10 on endosomes regulates the local balance between microtubule stability and dynamics through PAK2-JNK pathway and promotes axon outgrowth.
J Cell Sci 138;jcs263636:2025. DOI:10.1242/jcs.263636 - Lee M, Wakigawa T, Jia Q, Liu C, Huang R, Huang S, Nagao A, Suzuki T, Tomita K, Iwasaki S, and Takeuchi-Tomita N
Discrimination of initiator tRNA and start codon by mammalian mitochondrial initiation factor 3 in leaderless mRNA translation.
Nucleic Acids Res. 53(3):2025. DOI:10.1093/nar/gkaf021 - FukuchiK, NakashimaY, AbeN, KimuraS, HashiyaF, ShichinoY, LiuY, OgisuR, SugiyamS, KawaguchD, InagakM, MengZ, KajiharS, TadaM, UchidS, LiTT, MaityR, KawasakT, KimurY, IwasakiS, AbeH
Internal cap-initiated translation provides efficient protein production from circular mRNA.
Nat Biotechnol. :2025. DOI:10.1038/s41587-025-02561-8 - Nobuyuki Sakayori, Kazuki Fujii, Masanori Katakura, Mayumi Adachi, Yumie Koshidaka, Keizo Takao, Makoto Sugita
Mice born to mothers fed a diet high in omega-6 fatty acids and low in omega-3 fatty acids during pregnancy exhibit various behavioral changes including impaired social behaviors and enhanced recognition memory.
The Journal of Nutrition 155;775-787:2025. DOI:10.1016/j.tjnut.2024.12.031 - Ryosuke Fukuda, Shiori Beppu, Daichi Hinata, Yuka Kamada, Tsukasa Okiyoneda
Perturbation of EPHA2 and EFNA1 trans binding amplifies inflammatory response in airway epithelial cells.
iScience 28(2);111872:2025. DOI:10.1016/j.isci.2025.111872 - Bai, L.; Sawai, K.; Tani, T.; Nakai, M.; Matsusaka, H.; Ito, K.; Tomita, H.; Sugano, E.; Ozaki, T.; Fukuda, T
Adipose-derived cells surpass muscle-derived cells in primary cell isolation efficacy.
In Vitro Cell Dev Biol Anim 61 (1);1-7:2025. DOI:10.1007/s11626-024-00979-z - Notoya G, Kishikawa T, Yasugi K, Iwata T, Seimiya T, Miyabayashi K, Takahashi R, Yamamoto K, Ijichi H, Otsuka M, Fujishiro M
WWP1 inhibition suppresses the proliferation of pancreatic cancer cells by regulating the PI3K-AKT pathway.
Journal of Gastroenterology 60;370-384:2025. DOI:10.1007/s00535-024-02192-x - Ogawa O, Izumikawa K, Tate S, Isoyama S,,,,,,,, S, Dan S, Pommier Y, Murai J
SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis.
Molecular Cell 85(5);894, 912:2025. DOI:10.1016/j.molcel.2025.01.008 - Masatake Araki, Luna Ikeda, Takumi Yonemori, Kumiko Yoshinobu, Mariko Yamane, Takumi Ichikawa and Kimi Araki
Potential role of trap clone accumulation areas (TCAAs) in sustaining pluripotency in mouse embryonic stem cells.
Genes to Cells 30(2);e70011:2025. DOI:10.1111/gtc.70011 - Yuka Yoshizawa, Akihito Yokosuka, Mina Inomata, Tomoki Iguchi, Yoshihiro Mimaki
Steroidal constituents in the whole plants of Helleborus niger and their cytotoxic activity in vitro.
Phytochemistry 229;1142752:2025. DOI:10.1016/j.phytochem.2024.114272 - Fujiwara-Tani R, Nakashima C, Ohmori H, Fujii K, Luo Y, Sasaki T, Ogata R, Kuniyasu H
Significance of malic enzyme 1 in cancer: A review.
Curr. Issues Mol Biol 47;83:2025. DOI:10.3390/cimb47020083 - Nukaga S, Fujiwara-Tani R, Mori T, Kawahara I, Nishida R, Miyagawa Y, Goto K, Ohmori H, Fujii K, Sasaki T, Nakashima C, Luo Y, Kishi S, Ogata R, Kuniyasu H
Effects of antioxidant amino acids on cancer sarcopenia.
Int J Mol Sci 26;272:2025. DOI:10.3390/ijms26010272 - Fujiwara-Tani R, Luo Y, Ogata R, Fujii K, Sasaki T, Nishiguchi Y, Mori S, Ohmori H, Kuniyasu H
Energy metabolism and stemness and the role of lauric acid in reversing 5-fluorouracil resistance in colorectal cancer cells.
Int J Mol Sci 26;664:2025. DOI:10.3390/ijms26020664 - Otani T, Miyake T, Ota T, Yarimizu D, Nakagawa Y, Murai I, Okamura H, Hasegawa E, Doi M
Identification of Angiotensin II-Responsive Circadian Clock Gene Expression in Adrenal Zona Glomerulosa Cells and Human Adrenocortical H295R Cells.
Frontier in Endocrinology 16;1525844:2025. DOI:10.3389/fendo.2025.1525844 - Sasaki R, Luo Y, Kishi S, Ogata R, Nishiguchi Y, Sasaki T, Ohmori H, Fujiwara-Tani R, Kuniyasu H
Oxidative high mobility group box-1 accelerates mitochondrial transfer from mesenchymal stem cells to colorectal cancer cells providing cancer cell stemness.
Int J Mol Sci 26;1192:2025. DOI:10.3390/ijms26031192 - Mori S, Fujiwara-Tani R, Ogata R, Ohmori H, Fujii K, Luo Y, Sasaki T, Nishiguchi Y, Bhawal UK, Kishi S, Kuniyasu H
Anti-cancer and pro-immune effects of lauric acid on colorectal cancer cells.
Int J Mol Sci 26;1953:2025. DOI:10.3390/ijms26051953 - Murakami Y, Kasai Y, Masuda T, Ichikawa H, Ito T
Multiple functions of Cell adhesion molecule 1 (CADM1) and its role in the pathogenesis of cancer and other diseases.
Journal of Nippon Medical School 92:2025. - Akito Kosugi, Moeko Kudo, Ken-ichi Inoue, Masahiko Takada, Kazuhiko Seki
Bidirectional optogenetic modulation of peripheral sensory nerve activity: Induction vs. suppression through channelrhodopsin and halorhodopsin.
iScience :2025. DOI:10.1016/j.isci.2025.112178 - Osanai Y, Battulga B, Yamazaki R, Kobayashi K, Kobayashi K, Nakamura Y, Ueno M, Mizukami H, Yoshimura Y, Ohno N
GABA mediates experience-dependent regulation of myelination in the mouse visual pathway.
BioRxiv :2025. DOI:10.1101/2025.03.05.641594 - Hara, T., Meng S., Arao, Y., Saito, Y., Inoue, K., Alshammari, A.H., Hatakeyama,H., diLuccio,E., Vecchione, A., Hirotsu, T., Ishii, H
Non-Invasive Detection of Tumors by Volatile Organic.
biomedicines 13(1);109:2025. DOI:10.3390/biomedicines13010109 - Yan Wang, Yi Wang, (5名), Hiroshi Takano, (3名), Ryoji Yao, Jun Hamazaki, Shigeo Murata
The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation.
Nature Communications 16;1600:2025. DOI:10.1038/s41467-025-56867-x - M. Ohta, A. Okuda, K. Takahashi, S. Hosoya, Y. Yoshigoe, S. Saito
Synthesis and Properties of [3]Rotaxanes with Two Oligo(para-phenylene) Axles.
Chem. Eur. J. ;e202500522:2025. DOI:10.1002/chem.202500522 - Iwaki T, Nakamura S,...Ueno M, Kusaka T
Hydrogen gas inhalation ameliorates glomerular enlargement after hypoxic-ischemic insult in asphyxiated piglet model.
Sci Rep 15;1677:2025. DOI:10.1038/s41598-025-85231-8 - Ishido M.; Higashi K.; Mori H.; Ueno M.; Kurokawa K
DNA methylation profiles of transgenerational rat hyperactivity primed by silver nanoparticles: Comparison with valproate model rats of autism.
Behavioural Brain Research 477:2025. DOI:10.1016/j.bbr.2024.115293 - Yagi H.; Takao K.; Hattori S.; Minato Y.; Kuwahara-Otani S.; Maeda S.; Noguchi K.; Miyakawa T.; Sato M
Deletion of filamin A-interacting protein (FILIP) results in a weak grip strength and abnormal responses to nociceptive stimulation.
Neuroscience Letters 851:2025. DOI:10.1016/j.neulet.2025.138158 - Fujita T.; Aoki N.; Mori C.; Homma K.J.; Yamaguchi S
Molecular characterization of chicken DA systems reveals that the avian personality gene, DRD4, is expressed in the mitral cells of the olfactory bulb.
Frontiers in Neuroanatomy 19:2025. DOI:10.3389/fnana.2025.1531200 - Ide S.; Iwase N.; Arai K.; Kojima M.; Ushiyama S.; Ikeda K
Inhibitory effects of the selective μ-opioid receptor antagonist UD-030 on methamphetamine-induced conditioned place preference.
Neuropsychopharmacology Reports 45(1):2025. DOI:10.1002/npr2.12503 - Kobayashi, Y; Sato, R; Shimizu, Y; Fukui, R; Shibata, T; Tsukamoto, H; Tsubata, T; Miyake, K
CD20 and CD19 promote proliferation driven by the IgM-TLR9-L265P MyD88 complex.
Int. Immunol. :2025. DOI:10.1093/intimm/dxaf004 - Sato R, Liu K, Shibata T, Hoshino K, Yamaguchi K, Miyazaki T, .., Furukawa Y, Latz E, Nakatani K, Izumi Y, Nie Y, Taniguchi H, Miyake K.
RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells.
J. Exp. Med. 222(3);e20230647:2025. DOI:10.1084/jem.20230647 - Zhu F, Kanda H, Neyama H, Wu Y, Kato S, Hu D, Duan S, Noguchi K, Watanabe Y, Kobayashi K, Dai Y, Cui Y
Modulation of Nicotine-Associated Behaviour in Rats By μ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell.
Neurosci Bull. 40(12);1826-1842:2024. DOI:10.1007/s12264-024-01230-1 - Sato H, Meng S, Sasaki K, Kobayashi S, Kido K, Tsuji Y, Arao Y, Saito Y, Iwagami Y, Yamada D, Tomimaru Y, Noda T, Takahashi H, Motooka D, Uchida S, Ofusa K, Satoh T, Doki Y, Eguchi H, Hara T, Ishii H
Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality.
International Journal of Oncology 65(1);74:2024. DOI:10.3892/ijo.2024.5662 - Shichino Y, Yamaguchi T, Kashiwagi K, Mito M, Takahashi M, Ito T, Ingolia NT, Kuba K, Iwasaki S
eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition.
Nature Structural & Molecular Biology 31(10);1557-1566:2024. DOI:10.1038/s41594-024-01321-7 - Hara T, Meng S, Motooka D, Sato H, Arao Y, Tsuji Y, Yabumoto T, Doki Y, Eguchi H, Uchida S, Ishii H
Fat and proteolysis due to methionine, tryptophan, and niacin deficiency leads to alterations in gut microbiota and immune modulation in inflammatory bowel disease.
Cancer Science 115(7);2473-2485:2024. DOI:10.1111/cas.16153 - Hara T, Meng S, Sato H, Tatekawa S, Sasaki K, Takeda Y, Tsuji Y, Arao Y, Ofusa K, Kitagawa T, Yamada D, Takahashi H, Kobayashi S, Motooka D, Suzuki Y, Rennie S, Uchida S, Mori M, Ogawa K, Doki Y, Eguchi H, Ishii H
High N6-methyladenosine-activated TCEAL8 mRNA is a novel pancreatic cancer marker.
Cancer Science 115(7);2360-2370:2024. DOI:10.1111/cas.16152 - Jin M, Wang S, Gao X, Zou Z, Hirotsune S, Sun L
Pathological and physiological functional cross-talks of α-synuclein and tau in the central nervous system.
Neural Regen Res. 19(4);855-862:2024. DOI:10.4103/1673-5374.382231 - Saeki N., Inui-Yamamoto C., Ikeda Y. , Kanai Y., Kenji Hata4, Itoh S., Inubushi T., Akiyama S., Ohba S., Abe M
Deletion of Trps1 regulatory elements recapitulates postnatal hip joint abnormalities and growth retardation of Trichorhinophalangeal syndrome in mice.
Human Molecular Genetics 33;18:2024. DOI:10.1093/hmg/ddae102/7696522 - Yoshimori T, Kawami M, Kumagai Y, Futatsugi S, Yumoto R, Uchida Y, Takano M
Abemaciclib-induced epithelial-mesenchymal transition mediated by cyclin-dependent kinase 4/6 independent of cell cycle arrest pathway.
Int J Biochem Cell Biol 172;106601:2024. DOI:10.1016/j.biocel.2024.106601 - Shiraishi T, Katayama Y, Nishiyama M, Shoji H, Miyakawa T, Mizoo T, Matsumoto A, Hijikata A, Shirai T, Mayanagi K, Nakayama KI
The complex etiology of autism spectrum disorder due to missense mutations of CHD8.
Mol. Psychiatry 29;2145–2160:2024. DOI:10.1038/s41380-024-02491-y - Tomoe Matagawa, Yukiko Sasazawa, Koki Agui, Motoki Fujimaki, Sayaka Kawano, Akihiro Ogura, Ken-Ichi Takao, Masayuki Igarashi, Siro Simizu
Antiproliferative activities through accelerating autophagic flux by basidalin and its analogs in human cancer cells.
Bioorg Med Chem Lett 104;129713:2024. DOI:10.1016/j.bmcl.2024.129713 - Asahina R, Takahashi M, Takano H, Yao R, Abe M, Goshima Y, Ohshima T
The role of CRMP4 in LPS-induced neuroinflammation.
Brain Res 1841:2024. DOI:10.1016/j.brainres.2024.149094 - Kawai T, Morioka S, Miyata H, Andriani RT, Akter S, Toma G, Nakagawa T, Oyama Y, Iida-Norita R, Sasaki J, Watanabe M, Sakimura K, Ikawa M, Sasaki Y, Okamura Y
The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase.
Nature Communications 15;7289:2024. DOI:10.1038/s41467-024-51755-2 - Kawaguchi T, Hashimoto M, Nakagawa R, Minami R, Ikawa M, Nakayama JI, Ueda J
Comprehensive posttranslational modifications in the testis-specific histone variant H3t protein validated in tagged knock-in mice.
Scientific Reports 14;21305:2024. DOI:10.1038/s41598-024-72362-7 - Miki T, Okamoto Y, Ueno-Umegai M, Toyofuku R, Hattori S, Sakaba T
Single-vesicle imaging reveals actin-dependent spatial restriction of vesicles at the active zone, essential for sustained transmission.
Proc. Natl. Acad. Sci. USA 121;e2402152121:2024. DOI:10.1073/pnas.2402152121 - Toyoaki Maruta, Satoshi Kouroki, Mio Kurogi, Kotaro Hidaka, Tomohiro Koshida, Ayako Miura, Hikaru Nakagawa, Toshihiko Yanagita, Ryu Takeya, and Isao Tsuneyoshi
Comparison of nocifensive behavior in NaV1.7–, NaV1.8–, and NaV1.9–channelrhodopsin-2 mice by selective optogenetic activation of targeted sodium channel subtype-expressing afferents.
Journal of Neuroscience Research 102(10);e25386:2024. DOI:10.1002/jnr.25386 - Sin Yi Lee, Hirotaka Shoji, Aki Shimozawa, Hirofumi Aoyagi, Yoshiaki Sato, Kazuya Tsumagari, Junro Kuromitsu, Tsuyoshi Miyakawa, Daisuke Ito
Phenotypic insights into anti-IgLON5 disease in IgLON5-deficient mice.
Neurol Neuroimmunol. Neuroinflamm. 11(3);e200234:2024. DOI:10.1212/NXI.0000000000200234 - Sadakata M, Fujii K, Kaneko R, Hosoya E, Sugimoto H, Kawabata-Iwakawa R, Kasamatsu T, Hongo S, Koshidaka Y, Takase A, Iijima T, Takao K, Sadakata T
Maternal Immunoglobulin G Affects Brain Development of Mouse Offspring.
Journal of Neuroinflammation 21(114);1-20:2024. DOI:10.1186/s12974-024-03100-z - Sato, H., Meng, S., Hara, T., Tsuji, Y., Arao, Y., Sasaki, K., Kobayashi, S., di Luccio, E., Hirotsu, T., Satoh, T., Doki, Y., Eguchi, H., Ishii, H
Tissue-Resident Memory T Cells in Gastrointestinal Cancers: Prognostic Significance and Therapeutic Implications.
Biomedicines 12;1342:2024. DOI:10.3390/biomedicines12061342 - Daisuke Tatsuda, Masahide Amemiya, Chisato Nosaka, Ryuichi Sawa, Hideyuki Muramatsu, Masayuki Igarashi, Junjiro Yoshida, Tomokazu Ohishi, Manabu Kawada
Two new adenopeptins B and C inhibit sphere formation of pancreatic cancer cells.
The Journal of Antibiotics 77;73-84:2024. DOI:10.1038/s41429-023-00679-y - Kei-ichiro Ishiguro
Mechanisms of meiosis initiation and meiotic prophase progression during spermatogenesis.
Molecular Aspects of Medicine 97;101282:2024. DOI:10.1016/j.mam.2024.101282 - Ichiyama-Kobayashi S, Hata K, Wakamori K, Takahata Y, Murakami T, Yamanaka H, Takano H, Yao R, Uzawa N, Nishimura R
Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development.
JCI Insight. 9(11):2024. DOI:10.1172/jci.insight.175486 - Haruko Miyazaki, Saki Nishioka, Tomoyuki Yamanaka, Manabu Abe, Tomohiro Miyasaka, Nobuto Kakuda, Kazuhiro Yamakawa, Masahito Ikawa, Nobuyuki Nukina
Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP.
Transgenic Research 33(3);99-117:2024. DOI:10.1007/s11248-024-00382-0 - Yusuke Yoshigoe, Hirotaka Shimada, Takuya Takaki, Yoshitane Imai, Shinich Saito
Synthesis and Isolation of a Homochiral Nanohoop Composed of a Tröger's Base and Hexaparaphenylene.
Chem. Eur. J. ;e202304059:2024. DOI:10.1002/chem.202304059 - Meng, S., Hara, T. Miura, Y., Ishii, H
Fibroblast activation protein constitutes a novel target of chimeric antigen receptor T- cell therapy in solid tumors.
Cancer Science 00;1-11:2024. DOI:10.1111/cas.16285 - T Ooshio, Y Satoh, H Jiang, T Liu, K Fujii, T Ishikawa, K Igarashi, T Mashima, S Jin, K Matoba, M Mack, T Osawa, H Seimiya, T Soga, M Sonoshita
Identifying simultaneous inhibition of riboflavin metabolism and MEK as a novel therapeutic strategy for pancreatic cancer.
bioRxiv :2024. DOI:10.1101/2024.10.23.619807 - Osanai Y, Xing YL, Mochizuki S, Kobayashi K, Homman-Ludiye J, Cooray A, Poh J, Inutsuka A, Ohno N, Merson TD
5' transgenes drive leaky expression of 3′ transgenes in inducible bicistronic vectors.
Molecular Therapy Methods and Clinical Development 32;101288:2024. DOI:10.1016/j.omtm.2024.101288 - Alavattam KG, Esparza JM, Hu M, Shimada R, Kohrs AR, Abe H, Munakata Y, Otsuka K, Yoshimura S, Kitamura Y, Ishiguro K, Namekawa SH. et al
ATF7IP2/MCAF2 directs H3K9 methylation and meiotic gene regulation in the male germline.
Genes & Development 38;115-130:2024. DOI:10.1101/gad.351569.124 - Uchimura Y, Hino K, Hattori K, Kubo Y, Owada A, Kimura T, Sugawara L, Kume S, Bellier JP, Yanagisawa D, Shiino A, Nakayama T, Daigo Y, Mashimo T, Udagawa J
Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume.
PLOS One 19(8);e0309461:2024. DOI:10.1371/journal.pone.0309461 - Ageta-Ishihara N, Fukazawa Y, Takao K, Watanabe M, Miyakawa T, Inokuchi K, Bito H, Kinoshita M, et al
Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines.
Cell Reports 44(3);115352:2024. DOI:10.1016/j.celrep.2025.115352 - Okumura K, Morinaga T, Saito M, Tokunaga Y, Otoyama K, Tanaka S, Isogai E, Kawazu M, Togashi Y, Hasegawa Y, Wakabayashi Y
Targeting PAK1 is effective against cutaneous squamous cell carcinoma in a syngenic mouse model.
Cancer Sci. 115(8);2839-2845:2024. DOI:10.1111/cas.16246 - Ryuki Shimada, Kei-ichiro Ishiguro
Female-specific mechanisms of meiotic initiation and progression in mammalian oocyte development.
Genes to Cells 29(10);797-807:2024. DOI:10.1111/gtc.13152 - Ryo C Yanagita, Yoshiyuki Suzuki, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie
Effect of phenolic-hydroxy-group incorporation on the biological activity of a simplified aplysiatoxin analog with an (R)-(-)-carvone-based core.
Biosci. Biotechnol. Biochem. 88(9);992–998:2024. DOI:10.1093/bbb/zbae091 - Bai L, Tani T, Kobayashi T, Nouda R, Kanai Y, Sano Y, Takami K, Tomita H, Sugano E, Ozaki T, Kiyono T, Fukuda T
Establishment of immortalized Egyptian Rousettus bat cell lines.
FEBS Open Bio 14(4);598-612:2024. DOI:10.1002/2211-5463.13781 - Sekine A, Yasunaga G, Kumamoto S, Fujibayashi S, Munirah I, Bai L, Tani T, Sugano E, Tomita H, Ozaki T, Kiyono T, Inoue-Murayama M, Fukuda T
Characterization of Common Minke Whale (Balaenoptera Acutorostrata) Cell Lines Immortalized with the Expression of Cell Cycle Regulators.
Adv Biol (Weinh) 8(3);e2300227:2024. DOI:10.1002/adbi.202300227 - Kong W, Hara M, Tokunaga Y, Okumura K, Hirano Y, Miao J, Takenoshita Y, Hashimoto M, Sasaki H, Fujimori T, Wakabayashi Y, Fukagawa T
CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation.
Life Sci Alliance. 8(1);e202402927:2024. DOI:10.26508/lsa.202402927 - Meng, L.-H., Awakawa, T., Li, X.-M., Quan, Z., Yang, S.-Q., Wang, B.-G., Abe, I
Discovery of (±)-penindolenes reveals an unusual indole ring cleavage pathway catalyzed by P450 monooxygenase.
Angew. Chem. Int. Ed. 63;e202403963:2024. DOI:10.1002/anie.202403963 - Inoue, S., Nguyen, D. T., Hamada, K., Okuma, R., Okada, C., Okada, M., Abe, I., Sengoku, T., Goto, Y., Suga, H
De novo discovery of pseudo-natural prenylated macrocyclic peptide ligands.
Angew. Chem. Int. Ed. 63;e202409973:2024. DOI:10.1002/anie.202409973 - Saito K, Shigetomi E, Shinozaki Y, Kobayashi K, Parajuli B, Kubota Y, Sakai K, Hiroshi H, Nabekura J and Koizumi S
Microglia sense astrocyte dysfunction and prevent disease progression in an Alexander disease model.
Brain 147(2);698-716:2024. DOI:10.1093/brain/awad358 - Sumito Okuyama, Toshinobu Kuki & Hajime Mushiake
Recruitment of the premotor cortex during arithmetic operations by the monkey.
Scientific Reports 14;6450:2024. DOI:10.1038/s41598-024-56755-2 - Mako Aoki, Hiroto Takarada, Jumpei Maki, Takumi Kobayashi, Chihiro Tsukano, Kazuhiro Irie
Convergent Synthesis of Antitumor Aplysiatoxin Derivatives Based on a Combination of Ring-Closing and Cross Metathesis.
European Journal of Organic Chemistry 28;e202401074:2024. DOI:10.1002/ejoc.202401074 - Togo Ikuta, Hiroaki Kanda
Tumor formation at ileocecal junction associated with interleukin-1b upregulation in aryl hydrocarbon receptor-deficient mouse.
Journal of Biochemical and Molecular Toxicology 38(6);e23736:2024. DOI:10.1002/jbt.23736 - Saito H, Handa Y, Chen M, Schneider-Poetsch T, Shichino Y, Takahashi M, Romo D, Yoshida M, Fürstner A, Ito T, Fukuzawa K, Iwasaki S
DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs.
Nat Commun 15(1);7418:2024. DOI:10.1038/s41467-024-51635-9 - TreskyR, MiyamotoY, NagayosiY, YabukiY, ArakiK, TakahasiY, KomoharaY, GeH, NisiguchiK, FukudaT, KanekoH, MaedaN, MatsuuraJ, IwasakiS, SakakidaK, SiodaN, WeiFY, TomizawaK, ChujoT
TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice.
Nucleic Acids Res 52(15);9230-9246:2024. DOI:10.1093/nar/gkae520 - Honoki K, Tsujiuchi T, Kishi S, Kuniyasu H
Revisiting "Hallmarks of Cancer’ in Sarcomas".
J Cancer 15;1786-1804:2024. DOI:10.7150/jca.92844 - Ohmori H, Fujiwara-Tani R, Nukaga S, Nishida R, Fujii K, Mori S, Ogata R, Ikemoto A, Sasaki R, Kishi S, Luo Y, Kuniyasu H
Investigation of cancer-induced myocardial damage in autopsy cases − a comparison of chemotherapy and no chemotherapy cases.
Pathology Int 74;234-238:2024. DOI:10.1111/pin.13411 - Matsuura-Suzuki E, Kiyokawa K, Iwasaki S, Tomari Y
miRNA-mediated gene silencing in Drosophila larval development involves GW182-dependent and independent mechanisms.
EMBO J 43;6161-6179:2024. DOI:10.1038/s44318-024-00249-4 - Ichinose T, Kondo S, Kanno M, Shichino Y, Mito M, Iwasaki S, Tanimoto H
Translational regulation enhances distinction of cell types in the nervous system.
eLife 12:RP90713:2024. DOI:10.7554/eLife.90713.2 - Sakaguchi YM, Wiriyasermku O, Matsubayashi M, Kuniyasu H, Nagamori S, Mori E
Identification of three distinct cell populations for urate excretion in human kidney.
J Physiol Sci 74;1:2024. DOI:10.1186/s12576-023-00894-0 - Goto K, Fujiwara-Tani R, Nukaga S, Miyagawa Y, Kawahara I, Nishida R, Ikemoto A, Sasaki R, Ogata R, Kishi S, Luo Y, Fujii K, Ohmori H, Kuniyasu H
Berberine improves cancer-derived myocardial impairment in experimental cachexia models by targeting high-mobility group-1.
Int J Mol Sci 25;4735:2024. DOI:10.3390/ijms25094735 - Nishiguch Y, Fujiwara-Tani R, Nukaga S, Nishida R, Ikemoto A, Sasaki R, Mori S, Ogata R, Kishi S, Hojo Y, Shinohara H, Sho M, Kuniyasu H
Pterostilbene induces apoptosis from endoplasmic reticulum stress synergistically with anticancer drugs that deposit iron in mitochondria.
Int J Mol Sci 25;2611:2024. DOI:10.3390/ijms25052611 - Sasaki T, Fujiwara-Tani R, Luo Y, Ogata R, Sasaki R, Ikemoto A, Nishiguchi Y, Nakashima C, Kishi S, Fujii K, Ohmori H, Oue N, Kuniyasu H
Effects of high mobility group box-1 on mucosal immunity and epithelial differentiation in colitic carcinoma.
Int J Mol Sci 25;6846:2024. DOI:10.3390/ijms25136846 - Fujii K, Fujiwara-Tani R, Nukaga S, Ohmori H, Luo Y, Nishida R, Sasaki T, Miyagawa Y, Nakashima C, Kawahara I, Ogata R, Ikemoto A, Sasaki R, Kuniyasu H
Involvement of ferroptosis induction and oxidative phosphorylation inhibition in the anticancer-drug-induced myocardial injury: ameliorative role of pterostilbene.
Int J Mol Sci 25;3015:2024. DOI:10.3390/ijms25053015 - Miyagawa Y, Fujiwara-Tani R, Ikemoto A, Sasaki R, Ogata R, Nishiguchi Y, Goto K, Kawahara I, Sasaki T, Luo Y, Kuniyasu H
Significance of CD10 for Mucosal Immunomodulation by β-Casomorphin-7 in Exacerbation of Ulcerative Colitis.
Curr Issue Mol Biol 46;6472-6488:2024. DOI:10.3390/cimb46070386 - Luo Y, Fujiwara-Tani R, Kawahara I, Goto K, Nukaga S, Nishida R, Nakashima C, Sasaki T, Miyagawa Y, Ogata R, Fujii K, Ohmori H, Kuniyasu H
Cancerous conditions accelerate the aging of skeletal muscle via mitochondrial DNA damage.
Int J Mol Sci 25;7060:2024. DOI:10.3390/ijms25137060 - Kubota C, Torii R, Hosaka M, Takeuchi T, Gomi H, Torii S
Phogrin Regulates High-Fat Diet-Induced Compensatory Pancreatic β-Cell Growth by Switching Binding Partners.
Nutrients 16;169:2024. DOI:10.3390/nu16010169 - Nishida R, Nukaga S, Kawahara I, Miyagawa Y, Goto K, Nakashima C, Luo Y, Sasaki T, Fujii K, Ohmori H, Ogata R, Mori S, Fujiwara-Tani R, Kuniyasu H
Differential effects of three medium-chain fatty acids on mitochondrial quality control and skeletal muscle maturation.
Antioxidants 13;821:2024. DOI:10.3390/antiox13070821 - Yasui T, Mashiko M, Obi A, Mori H, Ito-Murata M, Hayakawa H, Kikuchi S, Hosaka M, Kubota C, Torii S, Gomi H
Insulin granule morphology and crinosome formation in mice lacking the pancreatic-specific β cell specific phogrin (PTRN2) gene.
Histochem. Cell Biol. Cytochem. 161;223-238:2024. DOI:10.1007/s00418-023-02256-8 - Nukaga S, Fujiwara-Tani R, Nishida R, Miyagawa Y, Goto K, Kawahara I, Nakashima C, Fujii K, Ogata R, Ohmori H, Kuniyasu H
Caprylic acid inhibits high mobility group box-1-induced mitochondrial damage in myocardial tubes.
Int J Mol Sci 25;8081:2024. DOI:10.3390/ijms25158081 - Shioiri T, Tsuchimoto J, Fukushige K, Takeuchi T, Naito M, Watanabe H, Sugiura N
Chondroitin sulfate-liposome: clustering toward high functional efficiency.
J Biochem 176(3);229-236:2024. DOI:10.1093/jb/mvae041 - Yoshida J, Hayashi T, Munetsuna E, Khaledian B, Sueishi F, Mizuno M, Maeda M, Watanabe T, Ushida K, Sugihara E, Imaizumi K, Kawada K, Asai N, Shimono Y
Adipsin-dependent adipocyte maturation induces cancer cell invasion in breast cancer.
Scientific Reports 14(1);18494:2024. DOI:10.1038/s41598-024-69476-3 - Amy Hui Ping Khor, Tomoyuki Koguchi, Hao Liu, Seiya Imoto, Hidewaki Nakagawa, Koichi Matsuda , Chizu Tanikawa
Regulation of the innate immune response and gut microbiome by p53.
Cancer science 15(1);184-196:2024. DOI:10.1111/cas.15991 - Kobayashi T, Yamashita A, Tsumaki N, Watanabe H
Subpopulations of fibroblasts derived from human iPS cells.
Commun Biol. 7:2024. DOI:10.1038/s42003-024-06419-8 - Hara S, Kono H, Suto N, Kojima H, Kishimoto K, Yoshino H, Niiyama S, Kakihana Y, Ichinose H
Inhibition of QDPR synergistically modulates intracellular tetrahydrobiopterin profiles in cooperation with methotrexate.
Biochem. Biophys. Res. Commun. 717;150059:2024. DOI:10.1016/j.bbrc.2024.150059 - Nasti A, Okumura M, Takeshita Y, Ho TTB, Sakai Y, Sato TA, Nomura C, Goto H, Nakano Y, Urabe T, Nakamura S, Tamura T, Matsubara K, Takamura T, Kaneko S
The declining insulinogenic index correlates with inflammation and metabolic dysregulation in non-obese individuals assessed by blood gene expression.
Diabetes Res Clin Pract. 208;111090:2024. DOI:10.1016/j.diabres.2024.111090 - Arbee S, Himeno T, Miura-Yura E, Kato M, Islam S, Jahan N, Kamiya H, Watanabe H
Versican maintains the homeostasis of adipose tissues and regulates energy metabolism.
Biochem Biopys Res Commun 727:2024. DOI:10.1016/j.bbrc.2024.150309 - Tsuchiya T, Nakamura S, Sugiyama Y, Nakao Y,..Fuke N, Kondo S, Koyano K, Miki T, Ueno M, Kusaka T
Hydrogen gas can ameliorate seizure burden during therapeutic hypothermia in asphyxiated newborn piglets.
Pediat Res 95;1536-1542:2024. DOI:10.1038/s41390-024-03041-6 - Seong HK, Kanda Y, Izutsu R, Jehung JP, Hamada J, Osaki M, Okamoto K, and Okada F
Prevention of liver metastasis via the pharmacological suppression of AMIGO2 expression in tumor cells.
Scientific Reports 14;28183:2024. DOI:10.1038/s41598-024-71827-z - Izuo, N., Ikejima, D., Uno, K., Asano, T., Muramatsu, S. I. & Nitta, A
Hippocampus-specific knockdown of Shati/Nat8l impairs cognitive function and electrophysiological response in mice.
Biochemical and Biophysical Research Communications 736;150435:2024. DOI:10.1016/j.bbrc.2024.150435 - Daichi Hinata, Ryosuke Fukuda, Hiroshi Ishiguro, Yuka Kamada, Tsukasa Okiyoneda
Enhanced CFTR modulator efficacy in ΔF508 CFTR mouse organoids by ablation of RFFL ubiquitin ligase.
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Amino acid influx via LAT1 regulates iron demand and sensitivity to PPMX-T003 of aggressive natural killer cell leukemia.
Leukemia 38;1731-1741:2024. DOI:10.1038/s41375-024-02296-6 - Yokoyama T, Manita S, Uwamori H, Tajiri M, Imayoshi I, Yagishita S, Murayama M, Kitamura K, Sakamoto M
A multicolor suite for deciphering population coding of calcium and cAMP in vivo.
Nature Methods 21;897-907:2024. DOI:10.1038/s41592-024-02222-9 - Nishitani N, Sasaki Y, Kaneda K
Effects of 3,4-methylenedioxymethamphetamine on neural activity in the nucleus accumbens of male mice engaged in social behavior.
Neuropsychopharmacology Reports 45;e12510:2024. DOI:10.1002/npr2.12510 - Sakamoto M, Yokoyama T
Probing neuronal activity with genetically encoded calcium and voltage fluorescent indicators.
Neuroscience Research ;S0168-0102(24)00076-2:2024. DOI:10.1016/j.neures.2024.06.004 - Wang L, Zhang J, Li W, Zhang X, Yokoyama T, Sakamoto M, Wang Y
The A-kinase anchoring protein Yotiao decrease the ER calcium content by inhibiting the store operated calcium entry.
Cell Calcium 121;1021906:2024. DOI:10.1016/j.ceca.2024.102906 - Okagawa S, Sakaguchi M, Okubo Y, Takekuma Y, Igata M, Kondo T, Takeda N, Araki K, Brandao BB, Qian WJ, Tseng YH, Kulkarni RN, Kubota N, Kahn CR, Araki E
Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression.
Nature Communications 15;9585:2024. DOI:10.1038/s41467-024-53835-9 - Rikiya Horikawa, Gen Onodera, Tsutomu Fukuda, Masanari Kimura
Efficient construction of a quinoline framework from alcohols, nitroarenes, and alkenes promoted by a trimetallic catalyst system.
Tetrahedron Chem 12;100108:2024. DOI:10.1016/j.tchem.2024.100108 - Sakaguchi M
The role of insulin signaling with FOXO and FOXK transcription factors.
Endocr Journal 71;939-944:2024. DOI:10.1507/endocrj.EJ24-0205 - Kageyama A, Ogonuki N, Wakai T, Namiki T, Kawata Y, Ozawa M, Yamada Y, Fukada T, Ogura A, Fissore A. Rafael, Kashiwazaki N, Ito J
The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice.
biorxiv :2024. DOI:10.1101/2024.09.11.612381 - Hikasa H, Kawahara K, Inui M, Yasuki Y, Yamashita K, Otsubo K, Kitajima S, Nishio M, Arima K, Endo M, Taira M, Suzuki A
A highly sensitive reporter system to monitor endogenous YAP1/TAZ activity and its application in various human cells.
Cancer Science 115;3370-3383:2024. DOI:10.1111/cas.16316 - Ogishi M,,,,(many authors),,,, Chikuma S,,,,,,,,,, Tangye SG
Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.
Immunity 57;2790-2807:2024. DOI:10.1016/j.immuni.2024.10.014 - Iizuka-Koga M, Ito M, Yumoto N, Mise-Omata S, Hayakawa T, Komai K, Chikuma S, Takahashi S, Matsumoto I, Sumida T, Yoshimura A
Reconstruction of Sjögren's syndrome-like sialadenitis by a defined disease specific gut-reactive single TCR and an autoantibody.
Clin Immunol 264;110258:2024. DOI:10.1016/j.clim.2024.110258 - Ryo Ishikawa, Kazuki Yanagida, Sayuri Shimada, Shogo Sasaki, Takatsugu Hirokawa, Yue Ma, Kazuo Nagasawa, Masayuki Tera
Topology-Selective Photo-Crosslinking of G-Quadruplexes via Dual G-Quartet and Groove Recognition.
Chem. Commun. 60;13550-13553:2024. DOI:10.1039/d4cc04804k - Hayabuchi H, Tokifuji Y, Takahashi H, Amagai M, Yoshimura A, *Chikuma S
Disruption of post-thymic tolerance in skin-reactive TCR transgenic mice through the interaction of lymphopenia and intestinal microbiota.
Int Immunol 36;413-424:2024. DOI:10.1093/intimm/dxae018 - Toya H, Okamatsu-Ogura Y, Yokoi S, Kurihara M, Mito M, Iwasaki S, Hirose T, and Nakagawa S
The essential role of architectural noncoding RNA Neat1 in cold-induced beige adipocyte differentiation in mice.
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New rocaglate derivatives tip the scale against brain tumors.
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Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior.
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Mettl1-dependent m7G tRNA modification is essential for maintaining spermatogenesis and fertility in Drosophila melanogaster.
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Translation of zinc finger domains induces ribosome collision and Znf598-dependent mRNA decay in zebrafish.
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Chemo-enzymatic total synthesis: current approaches toward the integration of chemical and enzymatic transformations.
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Nutritional imbalance between omega-6 and omega-3 polyunsaturated fatty acids during pregnancy increases the number of pyramidal neurons in the basolateral amygdala and anxiety-related behavior in offspring.
Journal of Nutritional Science and Vitaminology 70;411-421:2024. DOI:10.3177/jnsv.70.411 - Kanemura Y, Okada M, Igarashi M, Sekino Y, Shirao T, Nakamura M, Okano H, et al
Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains.
Cells 13;671:2024. DOI:10.3390/cells13080671 - Nozumi M, Sato Y, Nishiyama-Usuda M, Igarashi M
Identification of z-axis filopodia in growth cones using super-resolution microscopy.
J Neurochem 168;2974-2988:2024. DOI:10.1111/jnc.16162 - Sakai S, Tanaka Y, Tsukamoto Y, (中略10名), Fukushima A, Mita M, Nakane M, Doi M, Isaka Y, Kimura T
d-Alanine affects the circadian clock to regulate glucose metabolism in kidney.
Kidney360 5;237-251:2024. DOI:10.34067/KID.0000000000000345 - Fujita Y, Miyake T, Shao X, Aoki Y, Hasegawa E, Doi M
Omeprazole induces CYP3A4 mRNA expression but not CYP3A4 protein expression in HepaRG cells.
Biol. Pharm. Bull. 47;1218-1223:2024. DOI:10.1248/bpb.b24-00161 - Hsiao SW, Doi M
Circuits involving the hypothalamic suprachiasmatic nucleus for controlling diverse physiologies verified by the aid of optogenetics and chemogenetics.
Int Rev Cell Mol Biol :2024. DOI:10.1016/bs.ircmb.2024.06.002 - Miyake T, Inoue Y, Maekawa Y, and Doi M
Circadian Clock and Body Temperature.
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SoxC and MmpReg promote blastema formation in whole-body regeneration of fragmenting potworms Enchytraeus japonensis.
Nature Communications 15;6659:2024. DOI:10.1038/s41467-024-50865-1 - Nguyen Pham KT, Miyake T, Suzuki T, Kinoshita S, Hamada Y, Uehara H, Machida M, Nakajima T, Hasegawa E, and Doi M
Identification of Meibomian Gland Testosterone Metabolites Produced by Tissue-Intrinsic Intracrine Deactivation Activity.
iScience 28;111808:2024. DOI:10.1016/j.isci.2025.111808 - Honda S, Misawa N, Sato Y, Oikawa D, Tokunaga F
The hypothetical molecular mechanism of the ethnic variations in the manifestation of age-related macular degeneration; focuses on the functions of the most significant susceptibility genes.
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Suppression of the amyloidogenic metabolism of APP and the accumulation of Aβ by Alcadein α in the brain during aging.
Sci. Rep. 14;18471:2024. DOI:10.1038/s41598-024-69400-9 - Naoaki Kurisawa, Kazuya Teranuma, Akari Noto, Arihiro Iwasaki, Yoshiki Kabashima, Rie Nakajima, Chikashi Toyoshima, and Kiyotake Suenaga
Structure-Activity Relationship Studies on Iezoside, a Highly Potent Ca2+ ATPase Inhibitor.
Bulletin of the Chemical Society of Japan 97;uoae070:2024. DOI:10.1093/bulcsj/uoae070 - Hara, T., Meng, S., Tsuji, Y., Arao, Y., Saito, Y., Sato, H., Motooka, D., Uchida, S., Ishii, H
RN7SL1 may be translated under oncogenic conditions.
PANAS 121(12);e2312322121:2024. DOI:10.1073/pnas.2312322121 - Ojima D, Tominaga Y, Kubota T, Tada A, Takahashi H, Kishimoto Y, Tominaga T, Yamamoto T
Impaired Hippocampal Long-Term Potentiation and Memory Deficits upon Haploinsufficiency of MDGA1 Can Be Rescued by Acute Administration of D-Cycloserine.
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The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.
J Biol Chem. 300(5);107277:2024. DOI:10.1016/j.jbc.2024.107277 - Bai, L.; Wu, T.; Fukasawa, M.; Kashiwagi, S.; Tate, H.; Ozaki, T.; Sugano, E.; Tomita, H.; Ishii, T.; Akashi, T.; Fukuda, T
Detection of the nuclear translocation of androgen receptor using quantitative and automatic cell imaging analysis.
Tissue Cell 93;102631:2024. DOI:10.1016/j.tice.2024.102631 - Chukai, Y.; Ito, G.; Miki, Y.; Wakabayashi, K.; Itoh, K.; Sugano, E.; Tomita, H.; Fukuda, T.; Ozaki, T
Role of calpain-5 in cerebral ischemia and reperfusion injury.
Biochim Biophys Acta Gen Subj 1868(1);130506:2024. DOI:10.1016/j.bbagen.2023.130506 - Chukai, Y.; Sudo, T.; Fukuda, T.; Tomita, H.; Sugano, E.; Ozaki, T
Proteolysis of mitochondrial calpain-13 in cerebral ischemia-reperfusion injury.
Biochem Biophys Rep 39;101768:2024. DOI:10.1016/j.bbrep.2024.101768 - Maruoka, S.; Sugano, E.; Togawa, R.; Katayama, N.; Tabata, K.; Yoshizawa, N.; Morita, R.; Takita, Y.; Ozaki, T.; Fukuda, T.; Bai, L.; Tomita, H
Enhanced auditory responses in visual cortex of blind rats using intrinsic optical signal imaging.
Sci Rep 14(1);24740:2024. DOI:10.1038/s41598-024-76276-2 - Hong L, Tanaka M, Yasui M, Hara-Chikuma M
HSP90 promotes tumor associated macrophage differentiation during triple-negative breast cancer progression.
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Exploring the molecular and neuronal bases involved in central amygdala-dependent control of emotional behaviors.
Folia Pharmacologica Japonica 159(5);316-320:2024. DOI:10.1254/fpj.23052 - Isumi S, Futamura D, Hanasaki T, Sako Y, Miyata S, Kan H, Suzuki Y, Hasegawa N, Mushiake H, Kametaka S, Uchiyama Y, Osanai M, Lee-Hotta S
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NeuroImage 298;120791:2024. DOI:10.1016/j.neuroimage.2024.120791 - Mori, T., Sakurada, K., Awakawa, T., He, H., Ushimaru, R., Abe, I
Structure-function analysis of 2-sulfamoylacetic acid synthase in altemicidin biosynthesis.
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EphA-mediated regulation of stomatin expression in prostate cancer cells.
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Accumulation of mitochondrial DNA with a point mutation in tRNALeu(UUR) gene induces brain dysfunction in mice.
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Structure-function analysis of carrier protein-dependent 2-sulfamoylacetyltransferase in the biosynthesis of altemicidin.
Nature Commun 15(1);10896:2024. DOI:10.1038/s41467-024-55265-z - Asahi Kanno, Ryo Tanifuji, Satoshi Yoshida, Sota Sato, Saori Maki-Yonekura, Kiyofumi Takaba, Jungmin Kang, Kensuke Tono, Koji Yonekura, and Hiroki Oguri
Streamlined modular synthesis of saframycin substructure via copper-catalyzed three-component assembly and gold-promoted 6-endo cyclization.
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Diversity of set-related neuronal activity in the dorsal premotor cortex of monkeys during a path-planning task.
bioRxiv 630724:2024. DOI:10.1101/2024.12.30.630724 - Sada R, Yamamoto H, Matsumoto S, Harada A, Kikuchi A
Newly developed humanized anti-CKAP4 antibody suppresses pancreatic cancer growth by inhibiting DKK1-CKAP4 signaling.
Cancer Sci. 115;3358-3369:2024. DOI:10.1111/cas.16278 - Tatsuroh Kaneko, Asuka Oura, Yoshiki Imai, Ikue Kusumoto-Yoshida, Takuro Kanekura, Hiroyuki Okuno, Tomoyuki Kuwaki, Hideki Kashiwadani
Orexin neurons play contrasting roles in itch and pain neural processing via projecting to the periaqueductal gray.
Communications Biology 7;290:2024. DOI:10.1038/s42003-024-05997-x - Motooka Y, Tanaka H, Maeda Y, Katabuchi M, Mashimo T, Toyokuni S
Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats.
Scientific Reports 15(1);447:2024. DOI:10.1038/s41598-024-84184-8 - Zhou, L., Awakawa, T., Ushimaru, R., Kanaida, M., Abe, I
Characterization of aziridine-forming α-Ketoglutarate-dependent oxygenase in L-isovaline biosynthesis.
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Cancer Science 116(4);1139-1152:2024. DOI:10.1111/cas.16412 - Yuanqi Lin, Hiroaki Itoh, Shingo Dan, Masayuki Inoue
Methyl scanning approach for enhancing the biological activity of the linear peptidic natural product, efrapeptin C.
Chemical Science 15;19390-19399:2024. DOI:10.1039/D4SC04384G - Hikaru Nakagawa, Yohko Kage, Ayako Miura, Hikmawan Wahyu Sulistomo, Sho Matsuyama, Yoshihiro Yamashita, and Ryu Takeya
The expression of the formin Fhod3 in mouse tongue striated muscle.
Cell Structure and Function 49;111-122:2024. DOI:10.1247/csf.24044 - Hara, T., Meng, S., Arao, Y., Saito, Y., Inoue, K., Rennie, S., Ofusa, K., Doki, Y., Eguchi, Kitagawa, T., Ishii, H
Recent advances in noncoding RNA modifications of gastrointestinal cancer.
Cancer Science 116(1);8-20:2024. DOI:10.1111/cas.16380 - Yoshimura S, Shimada R, Kikuchi K, Kawagoe S, Abe H, Iisaka S, Fujimura S, Yasunaga K, Usuki S, Tani N, Ohba T, Kondoh E, Saio T, Araki K, Ishiguro K
Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions.
Nature Communications 15;3330:2024. DOI:10.1038/s41467-024-47601-0 - Li, S.-Y., Wang, G.-Q., Long, L., Gao, J.-L., Zhou, Z.-Q., Wang, Y.-H., Lv, J.-M., Chen, G.-D., Hu, D., Abe, I., Gao, H
Functional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines.
Nature Commun. 15;4588:2024. DOI:10.1038/s41467-024-49010-9 - Misuzu Ohta, Ayano Okuda, Shoichi Hosoya, Yusuke Yoshigoe, Shinichi Saito
Synthesis of Interlocked and Non-Interlocked Deca(para-phenylene) Derivatives by Ni-mediated Biaryl Coupling.
Chem. Eur. J. 30(16);e202304309:2024. DOI:10.1002/chem.202304309 - Saito, S.; Koizumi, Y.; Ito, Y.; Yasuda, T.; Yoshigoe, Y
Platinum-Catalyzed Diboration of Alkynes by 1,8-Diaminonaphthalene-Protected Diboronic Acid (B2(dan)2).
JOURNAL OF ORGANIC CHEMISTRY 89;16947-16951:2024. DOI:10.1021/acs.joc.4c01939 - Tomuro K, Mito M, Toh H, Kawamoto N, Miyake T, Chow SYA, Doi M, Ikeuchi Y, Shichino Y, Iwasaki S
Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts.
Nat Commun 15(1);7061:2024. DOI:10.1038/s41467-024-51258-0 - Awakawa, T., Mori, T., Barra, L., Ahmed, Y., Ushimaru, R., Gao, Y., Adachi, N., Senda, T., Terada, T., Tantillo, D.J., Abe, I
The structural basis of pyridoxal 5’-phosphate dependent β-NAD alkylating enzyme.
Nature Catalysis 7;1099-1108:2024. DOI:10.1038/s41929-024-01221-5 - Keisuke Koga, Kenta Kobayashi, Makoto Tsuda, Anthony E. Pickering, Hidemasa Furue
Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict.
Communications Biology 7;1:2024. DOI:10.1038/s42003-024-06008-9 - Noguchi J, Sugano E, Tomita H, Mizukami H, Watakabe A, Yamamori T, Ichinohe N
Altered projection-specific synaptic remodeling and its modification by oxytocin in an idiopathic autism marmoset model.
Commun Biol 7(1);642:2024. DOI:10.1038/s42003-024-06345-9 - Lee J, Mashima T, Kawata N, Yamamoto N, Morino S, Inaba S, Nakamura A, Kumagai K, Wakatsuki T, Takeuchi K, Yamaguchi K, Seimiya H
Pharmacological targeting of histone H3K27 acetylation/BRD4-dependent induction of ALDH1A3 for early-phase drug tolerance of gastric cancer.
Cancer Research Communications 4(5);1307-1320:2024. DOI:10.1158/2767-9764.CRC-23-0639 - Funaya S.; Takahashi Y.; Suzuki M.G.; Suzuki Y.; Aoki F
H3.1/3.2 regulate the initial progression of the gene expression program.
Nucleic Acids Research 52(11);6158-6170:2024. DOI:10.1093/nar/gkae214 - Taketsuru H.; Hirayama R.; Nakatsukasa E.; Natsume R.; Takao K.; Abe M.; Sakimura K
Generation of rat offspring from ovarian oocytes by xenotransplantation.
Scientific Reports 14(1):2024. DOI:10.1038/s41598-024-71030-0 - Nakayama H.; Miyazaki T.; Abe M.; Yamazaki M.; Kawamura Y.; Choo M.; Konno K.; Kawata S.; Uesaka N.; Hashimoto K.; Miyata M.; Sakimura K.; Watanabe M.; Kano M
Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum.
Communications Biology 7(1):2024. DOI:10.1038/s42003-024-06447-4 - Kurisawa N.; Iwasaki A.; Suenaga K
The Bioorganic Study of Iezoside: A Novel SERCA Inhibitor from the Marine Cyanobacterium.
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 82(11);1107-1116:2024. DOI:10.5059/yukigoseikyokaishi.82.1107 - Miyake K.; Shibata T.; Fukui R.; Murakami Y.; Sato R.; Hiranuma R
Endosomal Toll-Like Receptors as Therapeutic Targets for Autoimmune Diseases.
Advances in Experimental Medicine and Biology 1444;97-108:2024. DOI:10.1007/978-981-99-9781-7_7 - Sonobe R, Yang P, Suzuki MM, Shinjo K, Iijima K, Nishiyama N, Miyata K, Kataoka K, Kajiyama H, Kondo Y
Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta.
Cancer Sci. 115(6);1910-1923:2024. DOI:10.1111/cas.16150 - Hiranuma R.; Sato R.; Yamaguchi K.; Nakamizo S.; Asano K.; Shibata T.; Fukui R.; Furukawa Y.; Kabashima K.; Miyake K
Aberrant monocytopoiesis drives granuloma development in sarcoidosis.
International Immunology 36(4);183-196:2024. DOI:10.1093/intimm/dxad054 - Wang Y.; Tsukioka D.; Oda S.; Mitani H.; Aoki F
DNA repair is efficient in irradiated M phase zygot.
Journal of Reproduction and Development 70(3);197-201:2024. DOI:10.1262/jrd.2024-018 - Sugimoto C.; Fujita H.; Wakao H
Mice Generated with Induced Pluripotent Stem Cells Derived from Mucosal-Associated Invariant T Cells.
Biomedicines 12(1):2024. DOI:10.3390/biomedicines12010137 - Murakami R.; Chiba Y.; Miyatake N.; Miyai Y.; Matsumoto K.; Wakamatsu K.; Saito Y.; Hara M.; Murayama S.; Ueno M
Morphometry of choroid plexus epithelial cells in neurodegenerative diseases.
Neuropathology :2024. DOI:10.1111/neup.13019 - Hara T, Kazuno AA, Toyota T, Ueda J, Shuno T, Mukai J, Sato TA, Matsumoto N, Yoshikawa T, Takata
A case of bipolar I disorder with a loss-of-function variant of schizophrenia risk gene SETD1A: possible expansion of the relevant clinical spectrum supported by a meta-analysis.
Psychiatry Clin. Neurosci. 78(6);374-375:2024. DOI:10.1111/pcn.13669 - Aoki, N., Mori, C., Serizawa, S., Fujita, T., Yamaguchi, S. and Homma, K.J
Perihatch surge of thyroid hormone drives cognitive flexibility in newborn chick.
Science Advances 10;eadr5113:2024. DOI:10.1126/sciadv.adr5113 - Sunami Y.; Yoshino S.; Yamazaki Y.; Iwamoto T.; Nakamura T
Rapid increase of C/EBPα p42 induces growth arrest of acute myeloid leukemia (AML) cells by Cop1 deletion in Trib1-expressing AML.
Leukemia 38(12);2585-2597:2024. DOI:10.1038/s41375-024-02430-4 - Takeuchi K.; Nishimura Y.; Matsubara T.; Isoyama S.; Suzuki A.; Matsuura M.; Dan S
Prediction of cell cycle distribution after drug exposure by high content imaging analysis using low-toxic DNA staining dye.
Pharmacology Research and Perspectives 12(3):2024. DOI:10.1002/prp2.1203 - Ujie Y.; Saito S.; Fukaya K.; Urabe D.; Yaguchi T.; Arai M.A
Aspergillus terreus IFM 65899-THP-1 cells interaction triggers production of the natural product butyrolactone Ia, an immune suppressive compound.
Scientific Reports 14(1):2024. DOI:10.1038/s41598-024-79837-7 - Okitsu M.; Fujita M.; Moriya Y.; Kotajima-Murakami H.; Ide S.; Kojima R.; Sekiyama K.; Takahashi K.; Ikeda K
Mouse Model of Parkinson’s Disease with Bilateral Dorsal Striatum Lesion with 6-Hydroxydopamine Exhibits Cognitive Apathy-like Behavior.
International Journal of Molecular Sciences 25(14):2024. DOI:10.3390/ijms25147993 - Yoshimi K.; Kuno A.; Yamauchi Y.; Hattori K.; Taniguchi H.; Mikamo K.; Iida R.; Ishida S.; Goto M.; Takeshita K.; Ito R.; Takahashi R.; Takahashi S.; Mashimo T
Genome editing using type I-E CRISPR-Cas3 in mice and rat zygotes.
Cell Reports Methods 4(8):2024. DOI:10.1016/j.crmeth.2024.100833 - Kajita Y.; Fukuda Y.; Kawamatsu R.; Oyanagi T.; Mushiake H
Pentylenetetrazole kindling induces dynamic changes in GAD65 expression in hippocampal somatostatin interneurons.
Pharmacology Biochemistry and Behavior 239:2024. DOI:10.1016/j.pbb.2024.173755 - Yamagishi A.; Ikekubo Y.; Mishina M.; Ikeda K.; Ide S
Loss of the sustained antidepressant-like effect of (2R,6R)-hydroxynorketamine in NMDA receptor GluN2D subunit knockout mice.
Journal of Pharmacological Sciences 154(3);203-208:2024. DOI:10.1016/j.jphs.2024.01.008 - Ide S.; Ikeda K
Caenorhabditis elegans for opioid addiction research.
Current Opinion in Neurobiology 88:2024. DOI:10.1016/j.conb.2024.102914 - Kajita Y.; Mushiake H
Dynamic changes in seizure state and anxiety-like behaviors during pentylenetetrazole kindling in rats.
Epilepsy and Behavior 159:2024. DOI:10.1016/j.yebeh.2024.110019 - Terada Y, Obara K, Yoshioka Y, Ochiya T, Bito H, Tsuchida K, Ageta H, Ageta-Ishihara N.
Intracellular dynamics of ubiquitin-like 3 visualized using an inducible fluorescent timer expression system.
Biology Open 13;bio060345:2024. DOI:10.1242/bio.060345 - Fujiwara-Tani R, Sasaki T, Bhawal UK, Mori S, Ogata R, Sasaki R, Ikemoto A, Kishi S, Fujii K, Ohmori H, Sho M, Kuniyasu H
Nuclear MAST4 suppresses FOXO3 through interaction with AKT3 and induces chemoresistance in pancreatic ductal carcinoma.
Int J Mol Sci 25;4056:2024. DOI:10.3390/ijms25074056 - Cao, Z.-Q., Wang, G.-Q., Luo, R., Gao, Y.-H., Lv, J.-M., Qin, S.-Y., Chen, G.-D., Awakawa, T., Bao, X.-F., Mei, Q.-H., Yao, X.-S., Hu, D., Abe, I., Gao, H
Biosynthesis of enfumafungin-type antibiotic reveals an unusual enzymatic fusion pattern and unprecedented C-C bond cleavage.
J. Am. Chem. Soc. 146;12723-12733:2024. DOI:10.1021/jacs.4c02415 - Ohi, K; Nishizawa, D; Saito, T; Goto, T; Kubota, I; Shinoda, T; Fujikane, D; Hasegawa, J; Sato, N; Tanioka, F; Sugimura, H; Ikeda, K; Shioiri, T
Dietary habits and genetic susceptibility: correlations between nutritional intake and genetic risks for schizophrenia and bipolar disorder.
Transl. Psychiatr. 14(1);404:2024. DOI:10.1038/s41398-024-03105-5 - Wang, Y; Tsukioka, D; Oda, S; Suzuki, MG; Suzuki, Y; Mitani, H; Aoki, F
Involvement of H2A variants in DNA damage response of zygotes.
Cell Death Discov. 10;231:2024. DOI:10.1038/s41420-024-01999-0 - Ong KOK, Mok MMH, Niibori-Nambu A, Du L, Yanagida M, .., Iwasaki M, Minami T, Asou N, .., Shimizu R, Yamamoto M, Ito Y, Kham SKY, Yeoh AE, Chng WJ, Osato M.
Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia.
Exp. Hematol. 137;104255:2024. DOI:10.1016/j.exphem.2024.104255
2023年度
- Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, …Miyakawa T
Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.
Elife 12:RP89376, 2024. DOI:10.7554/eLife.89376 - Teyssonniere EM, Shichino Y, Mito M, Friedrich A, Iwasaki S, Schacherer J
Translation variation across genetic backgrounds reveals a post-transcriptional buffering signature in yeast.
Nucleic Acids Res 52(5):2434-2445, 2024. DOI:10.1093/nar/gkae030 - Hara, T., Meng, S., Tsuji, Y., Arao, Y., Saito, Y., Sato, H., Motooka, D., Uchida, S., Ishii, H.
RN7SL1 may be translated under oncogenic conditions.
PANAS 121(12):e2312322121, 2024. DOI:10.1073/pnas.2312322121 - Ishiguro H, Ushiki T, Honda A, Yoshimatsu Y, Ohashi R, Okuda S, … *Igarashi M, Sone H
Reduced chondroitin sulfate content prevents diabetic neuropathy through TGF-β signaling suppression.
iScience 27(4):109528, 2024. DOI:10.1016/j.isci.2024.109528 - Arai M, Suzuki E, Kitamura S, Otaki M, Kanai K, Yamasaki M, Kobayashi K, Tajika R, Lazarus M, de Kerchove d'Exaerde A, Masukawa D, Goshima Y. et al.
Enhancement of Haloperidol-Induced Catalepsy by GPR143, an L-Dopa Receptor, in Striatal Cholinergic Interneurons.
J Neurosci 44(11):e1504232024, 2024. DOI:10.1523/JNEUROSCI.1504-23.2024 - Ohguchi H,Ohguchi Y, Kubota S, Etoh K, Hamashima A, Usuki S, Yokomizo T, Bai J, Masuda T, Kawano Y, Harada T, Nakao M, Minami T, Hideshima T, Araki K, Sashida G
Multiple myeloma–associated DIS3 gene is essential for hematopoiesis, but loss of DIS3 is insufficient for myelomagenesis.
Blood Neoplasia 1 (1):1:100005, 2024. DOI:10.1016/j.bneo.2024.100005 - Apostolopoulos A, Kawamoto N, Chow SYA, Tsuiji H, Ikeuchi Y, Shichino Y, Iwasaki S
dCas13-mediated translational repression for accurate gene silencing in mammalian cells.
Nat Commun 15(1):2205, 2024. DOI:10.1038/s41467-024-46412-7 - Nakajima C, Sawada M, …Herranz-Pérez V, García-Verdugo JM, Ohno N, Arndt H-D, Trauner D, Tabata Y, Igarashi M, *Sawamoto K
Identification of the growth cone as a probe and driver of neuronal migration in the injured brain.
Nature Commun. 15(1):1877, 2024. DOI:10.1038/s41467-024-45825-8 - Oya, M., Miyasaka, Y., Nakamura, Y., Tanaka, M., Suganami, T., Mashimo, T., Nakamura, K.
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia.
Cell Metabolism 36(5):1044-1058.e10, 2024. DOI:10.1016/j.cmet.2024.02.010 - Shao X., Miyake T., Inoue Y., Hasegawa E., Doi M.
Temperature-Dependent Upregulation of Per2 Protein Expression Is Mediated by eIF2α Kinases PERK and PKR through PI3K Activation.
Biological and Pharmaceutical Bulletin 47:600-605, 2024. DOI:10.1248/bpb.b23-00739 - Ishikawa M, Yamamoto Y, Wulaer B, Kunisawa K, Fujigaki H, Ando T, Kimura H, Kushima I, Arioka Y, Torii Y, Mouri A, Ozaki N, Nabeshima T, Saito K.
Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction.
FEBS J. 291:945-964, 2024. DOI:10.1111/febs.17019 - Ozato, Y., Hara, T., Meng, S., Sato, H., Tatekawa, S., Uemura, M., Yabumoto, T., Uchida, S., Ogawa, K., Doki, Y., Eguchi, H., Ishii, H.
RNA methylation inflammatory bowel disease.
Cancer Science 115(3):723-733, 2024. DOI:10.1111/cas.16048 - Kusui Y, Izuo N, Tokuhara R, Asano T, Nitta A
Neuronal activation of nucleus accumbens by local methamphetamine administration induces cognitive impairment through microglial inflammation in mice.
Journal of Pharmacological Sciences 154(3):127-138, 2024. DOI:10.1016/j.jphs.2023.12.003 - Tanaka H, Motooka Y, Maeda Y, Sonehara R, Nakamura T, Kajiyama H, Mashimo T, Toyokuni S.
Brca2(p.T1942fs/+) dissipates ovarian reserve in rats through oxidative stress in follicular granulosa cells.
Free Radic Res 58(2):130-143, 2024. DOI:10.1080/10715762.2024.2320405 - Honda T, Ogata D, Tsurui M, Yoshida S, Sato S, Muraoka T, Kitagawa Y, Hasegawa Y, Yuasa J, Oguri H.
Rapid Synthesis of Chiral Figure-Eight Macrocycles Using a Preorganized Natural Product-Based Scaffold.
Angew. Chem. Int. Ed. 63:e202318548, 2024. DOI:10.1002/anie.202318548 - Takashima S, Okamura E, Ichiyama Y, Nishi K, Shimizu A, Watanabe C, Muto M, Matsumoto S, Tsukiyama-Fujii S, Tsukiyama T, Ogita H, …
Null mutation of exocyst complex component 3-like does not affect vascular development in mice.
Exp Anim 73:93-100, 2024. DOI:10.1538/expanim.23-0105 - Kumakura N, Singkaravanit-Ogawa S, Gan P, Tsushima A, Ishihama N, Watanabe S, Seo M, Iwasaki S, Narusaka M, Narusaka Y, Takano Y, Shirasu K
Guanosine-specific single-stranded ribonuclease effectors of a phytopathogenic fungus potentiate host immune responses.
New Phytol 242(1):170-191, 2024. DOI:10.1111/nph.19582 - Okumura K, Morinaga T, Saito M, Tokunaga Y, Otoyama K, Tanaka S, Isogai E, Kawazu M, Togashi Y, Araki K, Wakabayashi Y.
Deletion of Pak1 in CD11c-Positive Cells Confers Resistance to Mouse Skin Carcinogenesis.
Journal of Investigative Dermatology 24, 2024. DOI:10.1016/j.jid.2024.01.021 - Tanaka M, Fujikawa R, Sekiguchi T, Johnson OT, Tanaka D, Kumafuji K, Serikawa T, Trung HH, Hattori K, Mashimo T, Kuwamura M, Gestwicki JE, Kuramoto T, et al.
A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats.
Frontiers in Neuroscience 18, 2024. DOI:10.3389/fnins.2024.1263724 - Abdel-maksoud FM., Inui-Yamamoto C., Kawano A., Honma S., Saeki N., Abe M., Kuraki M., Ohba S., Wakisaka S.
Histological and immunohistochemical studies of the fungiform and circumvallate papillae through the life stages from 6- to 72-week-old Sprague-Dawley male rats.
Anatomical Record 307:414-425, 2024. DOI:10.1002/ar.25338 - X. Zhu, .., K. Araki, M. Araki, .., W. Wang
Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity.
Progress in Neurobiology 233:102568, 2024. DOI:10.1016/j.pneurobio.2024.102568 - Suzuki T, Hattori S, Mizukami H, Nakajima R, Hibi Y, Kato S, Matsuzaki M, Ikebe R, Miyakawa T, Yamakawa K.
Inversed effects of Nav1.2 deficiency at medial prefrontal cortex and ventral tegmental area for prepulse inhibition in acoustic startle response.
Molecular Neurobiology 61(2):622-634, 2024. DOI:10.1007/s12035-023-03610-6 - Daisuke Yoshioka, Takanori Nakamura, Yuji Kubota, Mutsuhiro Takekawa
Formation of the NLRP3 inflammasome inhibits stress granule assembly by multiple mechanisms.
The Journal of Biochemistry :mvae009, 2024. DOI:10.1093/jb/mvae009 - Takatsune Shimizu, Atsunobu Sagara, Yumi Fukuchi, Akihiro Muto
Single-agent nintedanib suppresses metastatic osteosarcoma growth by inhibiting tumor vascular formation.
Oncology Letters 7(3):123, 2024. DOI:10.3892/ol.2024.14254 - Tanaka M, Yokoyama T, Saito H, Nishimoto M, Tsuda K, Sotta N, Shigematsu H, Shirouzu M, Iwasaki S, Ito T, Fujiwara T
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.
Nat Chem Biol 20(5):605-614, 2024. DOI:10.1038/s41589-023-01513-0 - Kuraoka K, Nakamura K
Differential and temporally dynamic involvement of primate amygdala nuclei in face animacy and reward information processing.
bioRxiv, 2024. DOI:10.1101/2024.01.16.575972 - Nakamura M, Yoshimi A, Tokura T, Kimura H, Kishi S, Miyauchi T, Iwamoto K, Ito M, Sato-Boku A, Mouri A, Nabeshima T, Ozaki N, Noda Y.
Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter protein.
Pain. 165(5):1177-1186, 2024. DOI:10.1097/j.pain.0000000000003124 - Reiji Tanaka, Kei Watanabe, Takafumi Suzuki, Kae Nakamura, Masaharu Yasuda, Hiroshi Ban, Ken-ichi Okada, Shigeru Kitazawa
An easy-to-implement, non-invasive head restraint method for monkey fMRI.
NeuroImage 285:120479, 2024. DOI:10.1016/j.neuroimage.2023.120479 - Saito A, Murata H, Niitani K, Nagasaki J, Otoda A, Chujo Y, Yanagida J, Nishitani N, Deyama S, Kaneda K
Social defeat stress enhances the rewarding effects of cocaine through α1A adrenoceptors in the medial prefrontal cortex of mice.
Neuropharmacology 242:109757, 2024. DOI:10.1016/j.neuropharm.2023.109757 - Jun Takouda, Fumito Ishibashi, Jun Ishihara, Tsutomu Fukuda, Kohsuke Takeda, et al.
Identification of Azalamellarin N as a Pyroptosis Inhibitor.
Biological and Pharmaceutical Bulletin 47:28-36, 2024. DOI:10.1248/bpb.b23-00569 - Tokifuji Y, Hayabuchi H, Sasaki T, Hara-Chikuma M, Hirota K, Takahashi H, Amagai M, Yoshimura A, Chikuma S
Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition.
iScience 27:108646, 2024. DOI:10.1016/j.isci.2023.108646 - 吉田 香，魏 民，鈴木 周五, 藤岡 正喜, 長谷川 千尋，中川 歩，南 美帆，寺本 勲
中高年のサプリメント摂取によって起こるカルシウム過剰摂取が老人性認知症に及ぼす影響.
Trace Nutrients Research 40:70-76, 2023. DOI:10.51029/jtnrs.40.0_70 - Ryota Shizu, Natsuki Makida, Keiichiro Sobe, Mai Ishimura, Aki Takeshita, Takuomi Hosaka, Yuichiro Kanno, Takamitsu Sasaki, and Kouichi Yoshinari
Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation.
Toxicological Sciences 198(1):101-112, 2024. DOI:10.1093/toxsci/kfad129 - Meng, S., Hara, T., Sato, H., Tatekawa, T., Tsuji, Y., Saito, Y., Hamano, Y., Arao, Y., Gotoh, N., Ogawa, K., Ishii, H.
Revealing neuropilin expression patterns in pancreatic cancer: from single-cell to therapeutic opportunities.
Oncology Letters 27(3):113, 2024. DOI:10.3892/ol.2024.14247 - Hoshino K, Nakazawa S, Yokobori T, Hagiwara K, Ishii N, Tsukagoshi M, Igarashi T, Araki K, Harimoto N, Tokunaga F, Shirabe K.
RNF31 promotes proliferation and invasion of hepatocellular carcinoma via nuclear factor kappaB activation.
Sci Rep 14:346, 2024. DOI:10.1038/s41598-023-50594-3 - Kondo N, Utsumi T, Shimizu Y, Takemoto A, Oh-Hara T, Uchibori K, Subat-Motoshi S, Ninomiya H, Takeuchi K, Nishio M, Miyazaki Y, Katayama R.
MIG6 loss confers resistance to ALK/ROS1 inhibitors in NSCLC through EGFR activation by low-dose EGF.
JCI insight 8:e173688, 2023. DOI:10.1172/jci.insight.173688 - YoshimotoR,NakayamaY,NomuraI,YamamotoI,NakagawaY,TanakaS,KuriharaM,SuzukiY,KobayashiT,Kozuka-HataH,OyamaM,MitoM,IwasakiS,YamazakiT,HiroseT,ArakiK,NakagawaS
4.5SH RNA counteracts deleterious exonization of SINE B1 in mice.
Mol Cell 83(24):4479-4493.e6, 2023. DOI:10.1016/j.molcel.2023.11.019 - Suzuki S, Takahashi N, Imamura Y, Sakamoto S, Ichikawa T, Kubota Y, Wada T, Yamazaki Y, Sasano H, Ikeda JI, Tatsuno I, Yokote K.
Challenges in the diagnosis of the enigmatic primary adrenal leiomyosarcoma: two case reports and review of the literature.
BMC Endocr Disord 23:276, 2023. DOI:10.1186/s12902-023-01530-z - Imamura-Uehara Y, Yasuda-Yamahara M, Kuwagata S, Yamahara K, Yoshibayashi M, Tanaka-Sasaki Y, Shimizu A, Ogita H, Chin-Kanasaki M, Kume S.
Establishment of a novel mouse model of renal artery coiling-based chronic hypoperfusion-related kidney injury.
Biochem Biophys Rep 37:101607, 2023. DOI:10.1016/j.bbrep.2023.101607 - Tayo Katano, Kohtarou Konno, Keizo Takao, Manabu Abe, Akari Yoshikawa, Tsuyoshi Miyakawa, Kenji Sakimura, Masahiko Watanabe, Seiji Ito & Takuya Kobayashi
Brain-enriched guanylate kinase-associated protein, a component of the post-synaptic density protein complexes, contributes to learning and memory.
Scientific Reports 13(1):22027, 2023. DOI:10.1038/s41598-023-49537-9 - Kitamura, K., Hoshino, T., Okabe, A., Fukuyo, M., Rahmutulla, B., Tanaka, N., Tanaka, T., Shida, T., Ueda, M., Kaneda, A., Ishii, H., Matsushita, K. et al
The link of mRNA and rRNA transcription as a novel therapeutic target for cancer.
Molecular Sciences 24:17341, 2023. DOI:10.3390/ijms242417341 - Zhao X, Ma D, Ishiguro K, Saito H, Akichika S, Matsuzawa I, Mito M, Irie T, Ishibashi K, Wakabayashi K, Sakaguchi Y, Yokoyama T, Mishima Y, Shirouzu M, IwasakiS, Suzuki Ta, Suzuki Ts
Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell 186(25):5517-5535.e24, 2023. DOI:10.1016/j.cell.2023.10.026 - Izuo N, Miyanishi H, Nishizawa D, Fujii T, Hasegawa J, Sato N, Tanioka F, Sugimura H, Ikeda K, Nita A.
DNA methylation status of SHATI/NAT8L promoter in the blood of cigarette smokers.
Neuropsychopharmacol Rep 43(4):570-575, 2023. DOI:10.1002/npr2.12373 - Asano T, Takemoto H, Horita T, Tokutake T, Izuo N, Mochizuki T, Nitta A.
Sleep disturbance after cessation of cannabis administration in mice.
Neuropsychopharmacol Rep 43(4):505-512, 2023. DOI:10.1002/npr2.12329 - Yanagawa H, Hara Y, Ando F, Suzuki S, Fujiki T, Oikawa D, Yui N, Mandai S, Mori Y, Susa K, Mori T, Sohara E, Tokunaga F, Uchida S.
LRBA signalosomes activate vasopressin-induced AQP2 trafficking at recycling endosomes.
J Physiol. 601:5437-5451, 2023. DOI:10.1113/JP285188 - Kadomatsu T, Hara C, Kurahashi R, Horiguchi H, Morinaga J, Miyata K, Kurano S, Kanemaru H, Fukushima S, Araki K, Baba M, Linehan WM, Kamba T, Oike Y.
ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion.
Molecular Oncology 17:2637-2658, 2023. DOI:10.1002/1878-0261.13490 - Usukhbayar N, Takano Y, Uesugi S, Muroi M, Osada H, Kimura KI.
3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation.
Free Radic Res 57:208-222, 2023. DOI:10.1080/10715762.2023.2229005 - 渡邉涼香、鈴木佐和子
研修道場 ポイントはここだ下垂体機能検査の実際Q&A.
糖尿病・内分泌プラクティスWeb :a0091, 2023. DOI:10.57554/a0091 - Hideto Watanabe
Versican and versikine: The dynamism of the extracellular matrix.
Proteoglycan Research 1(4):e13, 2023. DOI:10.1002/pgr2.13 - Gyoten M, Luo Y, Fujiwra-Tani R, Mori S, Ogata R, Kishi S, Kuniyasu H
Lovastatin treatment inducing apoptosis in human pancreatic cancer cells by inhibiting cholesterol rafts in plasma membrane and mitochondria.
Int J Mol Sci 24:16814, 2023. DOI:10.3390/ijms242316814 - Lasham DJ, Arta RK, Hadi AF, Egawa J, Lemmon VP, Takasugi T, Igarashi M, Someya T.
Effects of MAP4K inhibition on neurite outgrowth.
Mol Brain. 16(1):79, 2023. DOI:10.1186/s13041-023-01066-2 - Kanatsu-Shinohara M, Shiromoto Y, Ogonuki N, Inoue K, Hattori S, Miura K, Watanabe N, Hasegawa A, Mochida K, Yamamoto T, Miyakawa T, Ogura A, Shinohara T.
Intracytoplasmic sperm injection induces transgenerational abnormalities in mice.
J Clin Invest 133:e170140, 2023. DOI:10.1172/JCI170140 - Kishi S, Mori S, Fujiwara-Tani R, Ogata R, Sasaki R, Ikemoto A, Goto K, Sasaki T, .. Luo Y, Bhawal UK, Fujimoto K, Nakagawa H, Kuniyasu H
ERVK13-1/miR-873-5p/GNMT axis promotes metastatic potential in human bladder cancer though sarcosine production.
Int J Mol Sci 24:16367, 2023. DOI:10.3390/ijms242216367 - Esaki H, Izumi S, Fukao A, Nishitani N, Deyama S, Kaneda K
Varenicline enhances recognition memory via α7 nicotinic acetylcholine receptors in the medial prefrontal cortex in male mice.
Neuropharmacology 239:109672, 2023. DOI:10.1016/j.neuropharm.2023.109672 - Ushimaru, R., Cha, L., Shimo, S., Li, X., Paris, J., Mori, T., Miyamoto. K., Coffer, L., Uchiyama, M., Guo, Y., Chang, W-c., Abe, I.
Mechanistic analysis of the stereodivergent nitroalkane cyclopropanation catalyzed by nonheme iron enzymes.
J. Am. Chem. Soc. 145:24210-24217, 2023. DOI:10.1021/jacs.3c08413 - Kesner AJ, Mozaffarilegha M, Thirtamara Rajamani K, Arima Y, Harony-Nicolas H, Hashimotodani Y, Ito HT, Song J, Ikemoto S
Hypothalamic Supramammillary Control of Cognition and Motivation.
journal of neurosience 43(45):7538-7546, 2023. DOI:10.1523/JNEUROSCI.1320-23.2023 - Mezawa Y, Wang T, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Yang L, Maruyama R, Seimiya H, Orimo A
Glutamine deficiency drives TGF-β signaling activation that gives rise to myofibroblastic carcinoma-associated fibroblasts.
Cancer Science 114(11):4376-4387, 2023. DOI:10.1111/cas.15955 - Youichi Tajima, Futoshi Shibasaki, Hisao Masai
Cell fusion upregulates PD-L1 expression and promotes tumor formation.
Oncogene 31(1):158-173, 2023. DOI:10.1038/s41417-023-00693-0 - Katami H, Suzuki S, Fujii T, Ueno M, Tanaka A, Ohta KI, Miki T, Shimono R.
Genetic and histopathological analysis of spermatogenesis after short-term testicular torsion in rats.
Pediatric Research 94:1650- 1658, 2023. DOI:10.1038/s41390-023-02638-7 - Khaledian B, Thibes L, Shimono Y.
Adipocyte regulation of cancer stem cells.
Cancer Science. 114:4134-4144, 2023. DOI:10.1111/cas.15940 - A Honda, M Nozumi, Y Ito, R Natsume, M Abe, H Uchino, N Matsushita, K Ikeda, M Arita, K Sakimura, M Igarashi
Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts.
Cell Reports 42(10):113195, 2023. DOI:10.1016/j.celrep.2023.113195 - Kono, H., Hara, S., Furuta, T., Ichinose, H.
Binding profile of quinonoid-dihydrobiopterin to quinonoid-dihydropteridine reductase examined by in silico and in vitro analyses.
Journal of Biochemistry 174(5):441-450, 2023. DOI:10.1093/jb/mvad062 - Soh JEC, Shimizu A, Sato A, Ogita H.
Novel cardiovascular protective effects of RhoA signaling and its therapeutic implications.
Biochem Pharmacol 218:115899, 2023. DOI:10.1016/j.bcp.2023.115899 - Ryuki Shimada, Yuzuru Kato, Naoki Takeda, Sayoko Fujimura, Kei-ichiro Yasunaga, Shingo Usuki, Hitoshi Niwa, Kimi Araki, Kei-ichiro Ishiguro
STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells.
Nature Communications 14:6443, 2023. DOI:10.1038/s41467-023-42259-6 - Sawako Suzuki, Divya Venkatesh, Tomoaki Tanaka, Carol Prives
GLS2 shapes ferroptosis in hepatocellular carcinoma.
Oncotarget 14:900-903, 2023. DOI:10.18632/oncotarget.28526 - Ushimaru, R., Ding, Y., Mori, T., Miyamoto, K., Uchiyama, M., Abe, I
Structural and mechanistic insights into the C–C bond forming rearrangement reaction catalyzed by heterodimeric hinokiresinol synthase.
J. Am. Chem. Soc. 145:21966-21973, 2023. DOI:10.1021/jacs.3c06762 - Ikeda Y., Tani S., Moriishi T., Kuroda A., et al.
Modeling of intramembranous ossification using human pluripotent stem cell-derived paraxial mesoderm derivatives.
Regenerative Therapy 24:536-546, 2023. DOI:10.1016/j.reth.2023.09.017 - Miyanishi H, Suga S, Sumi K, Takakuwa M, Izuo N, Asano T, Muramatsu SI, Nitta A.
The Role of GABA in the Dorsal Striatum-Raphe Nucleus Circuit Regulating Stress Vulnerability in Male Mice with High Levels of Shati/Nat8l.
eNeuro 10, 2023. DOI:10.1523/ENEURO.0162-23.2023 - Velissari, R., Ilieva, M., Dao, J., Miller, H. E., Madsen, J. H., Gorodkin, J. Aikawa, M., Ishii, H., Uchida, S.
Systematic analysis and characterization of long non-coding RNA genes in inf lammatory bowel disease.
Briefings in Functional Genomics, 2023. DOI:10.1093/bfgp/elad044 - Moon JY, Miyazaki T, Muroi M, Watanabe N, Shin R.
Chapter Fifteen - Isolation of novel chemical components and their plant target proteins under selenium stress.
Methods Enzymol 680:421-438, 2023. DOI:10.1016/bs.mie.2022.07.035 - Tomoda, F., Koike, T., Nitta, A., Kurosaki, H., Sugimori, H., Oh-Hara, M., & Kinugawa, K
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Journal of hypertension, 41(10):1571-1577, 2023. DOI:10.1097/HJH.0000000000003507 - Shinzawa K, Matsumoto S, Sada R, Harada A, Saitoh K, Kato K, Ikeda S, Hirayama A, Yokoi K, Tanemura A, Nimura K, Ikawa M, Soga T, Kikuchi A.
GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation.
Oncogene 42:3142-3156, 2023. DOI:10.1038/s41388-023-02803-6 - Hori K, Yamazaki S, Ohtaka-Maruyama C, Ono T, Iguchi T, Masai H
Cdc7 kinase is required for postnatal brain development.
Genes Cells 28:679-693, 2023. DOI:10.1111/gtc.13059 - Moriya Y, Kasahara Y, Ishikawa K, Hall FS, Hagino Y, Hen R, Ikeda K, Uhl GR, Sora I.
Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization.
Behavioral Pharmacology 34:393-403, 2023. DOI:10.1097/FBP.0000000000000745 - Wang Y, Hongu T, Nishimura T, Takeuchi Y, Takano H, Daikoku T, Yao R, Gotoh N
Mitochondrial one-carbon metabolic enzyme MTHFD2 facilitates mammary gland development during pregnancy.
Biochem Biophys Res Commun 674:183-189, 2023. DOI:10.1016/j.bbrc.2023.06.074 - Kazuhiko Nishida, Shinji Matsumura, Hitoshi Uchida, Manabu Abe, Kenji Sakimura, Tudor Constantin Badea, Takuya Kobayashi
Brn3a controls the soma localization and axonal extension patterns of developing spinal dorsal horn neurons.
PLOS ONE 18:e0285295, 2023. DOI:10.1371/journal.pone.0285295 - Sato A, Tsukiyama T, Komeno M, .., Yamada A, Ema M, Ogita H.
Generation of a familial hypercholesterolemia model in non-human primate.
Sci Rep 13:15649, 2023. DOI:10.1038/s41598-023-42763-1 - Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Nogawa T, Ohishi T, Ohba S, Kawada M, Yamazaki K, Dan S, Dohmae N, Osada H.
Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling.
Oncol. Res. 31(6):833-844, 2023. DOI:10.32604/or.2023.030241 - Nobuyoshi Takeuchi, Yusuke Imamura, Kazuki Ishiwata, Manato Kanesaka, Yusuke Goto, Tomokazu Sazuka, Sawako Suzuki, Shinichi Sakamoto, Tomohiko Ichikawa
Cushing's syndrome in pregnancy in which laparoscopic adrenalectomy was safely performed by a retroperitoneal approach.
IJU Case Reports 10:415-418, 2023. DOI:10.1002/iju5.12637 - Rios A, Nonomura S, Kato S, Yoshida J, Matsushita N, Nambu A, Takada M, Hira R, Kobayashi K, Sakai Y, Kimura M, Isomura Y
Reward expectation enhances action-related activity of nigral dopaminergic and two striatal output pathways.
Communications Biology 6:914, 2023. DOI:10.1038/s42003-023-05288-x - Takuya Nagai, Tomohisa Sekimoto, Etsuo Chosa, Kimi Araki, Masatake Araki, Taro Funamoto,, et al.
Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway.
Sci. Rep. 13:14639, 2023. DOI:10.1038/s41598-023-41837-4 - Takuma Shibata, Ryota Sato, Masato Taok, Shin-Ichiroh Saitoh, Mayumi Komin, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Moto, Jiro Kitaur, ……, Kensuke Miyake
TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.
Journal of Experimental Medicine (JEM) 220(9):e20230054, 2023. DOI:10.1084/jem.20230054 - Kubota H, Kunisawa K, Wulaer B, Hasegawa M, Kurahashi H, Sakata T, Nagao S, Nagai T, Furuyashiki T, Narumiya S, Saito K, Nabeshima T, Mouri A.
High salt induces cognitive impairment via the interaction of the angiotensin II-AT1 and prostaglandin E2-EP1 systems.
Br J Pharmacol. 180:2393-2411, 2023. DOI:10.1111/bph.16093 - Toyokuni S, Kong Y, Katabuchi M, Maeda Y, Motooka Y, Ito F, Yanatori I.
Iron links endogenous and exogenous nanoparticles.
Arch Biochem Biophys. 745:109718, 2023. DOI:10.1016/j.abb.2023.109718 - Sato, H., Hara, T., Meng, S., Tsuji, Y., Arao, Y., Saito., Sasaki, K., Kobayashi, S., Doki, Y., Eguchi, H., Ishi, H.
Multifaced roles of desmoplastic reaction and fibrosis in pancreatic cancer progression : Current understanding and future directions.
Cancer Science 114(9):3487-3495, 2023. DOI:10.1111/cas.15890 - 鈴木佐和子、横手幸太郎
特集 徹底攻略 副腎腫瘍2023 泌尿器科医が知っておくべき重要ポイント 両側副腎皮質大結節性過形成.
臨床泌尿器科 77(10):5, 2023. - Suzuki MM, Iijima K, (以下17名), Kondo Y.
TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation.
Nature Communications 14(1):4521, 2023. DOI:10.1038/s41467-023-40243-8 - Ishimura R#, Ito S#, Mao G, Komatsu-Hirota S, Inada T*, Noda NN*, Komatsu M*.
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control.
Sci Adv. 9(33):eadh3635, 2023. DOI:10.1126/sciadv.adh3635 - Ohmori I, Ouchida M, Hada Y, Uchida HA, Toyokuni S, Mashimo T.
Txn1 mutation is a monogenic cause of chronic kidney disease associated with mitochondrial dysfunction in rats.
BioRxiv, 2023. DOI:10.1101/2023.08.14.553187 - Tamura S, Ishiguro H, Suwabe T, Katagiri T, Cho K, Fuse K, Shibasaki Y, Mikami T, Shindo T, Kitagawa H, Igarashi M, Sone H, Masuko M, *Ushiki T
Genetic manipulation resulting in decreased donor chondroitin sulfate synthesis mitigates hepatic GVHD via suppression of T cell activity.
Sci Rep 13:13098, 2023. DOI:10.1038/s41598-023-40367-3 - Sato, H.; Hara, T.; Meng, S., Tsuji, Y., Arao, Y., Sasaki, K., Miyoshi, N., Kobayashi, S., Doki, Y., Eguchi, H. et al
Drug discovery and development of miRNA-based nucleotide drugs for gastrointestinal cancer.
Biomedicines 11(8):2235, 2023. DOI:10.3390/biomedicines11082235 - Funasaki S, Hatano A, Nakatsumi H, Koga D, Sugahara O, Yumimoto K, Baba M, Matsumoto M, Nakayama KI.
A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection.
iScience 26:107552, 2023. DOI:10.1016/j.isci.2023.107552 - Gavin Tay, Toshiaki Wayama, Hiroki Takezawa,* Satoshi Yoshida, Sota Sato,* Makoto Fujita,* Hiroki Oguri*
Synthetic Modulation of an Unstable Dehydrosecodine-type Intermediate and Its Encapsulation into a Confined Cavity Enable Its X-ray Crystallographic Observation.
Angew. Chem. Int. Ed. 62:e202305122, 2023. DOI:10.1002/ange.202305122 - 向井 淳、福田 茉由
統合失調症の未来 ─研究と治療.
医学のあゆみ 286(6), 2023. - Ageta-Ishihara N, Takemoto-Kimura S, Kondo Y, Okamura M, Bito H.
Lipidation states orchestrate CLICK-III/CaMKIγ's stepwise association with Golgi and rafts-enriched membranes and specify its functional coupling to STEF-Rac1-dependent neurite extension.
Frontiers in Cellular Neuroscience 17:1204302, 2023. DOI:10.3389/fncel.2023.1204302 - Tsuyama T, Sato Y, Yoshizawa T, Matsuoka T, Yamagata K
Hypoxia causes pancreatic beta-cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE40.
EMBO reports 24:e56227, 2023. DOI:10.15252/embr.202256227 - Ryobu Tachi, Kazutaka Ohi, Daisuke Nishizawa, Midori Soda, Daisuke Fujikane, Junko Hasegawa, .., Kazutaka Ikeda and Toshiki Shioiri
Mitochondrial Genetic Variants Associated with Bipolar Disorder and Schizophrenia in a Japanese Population.
International Journal of Bipolar Disorders 11(1):26, 2023. DOI:10.1186/s40345-023-00307-6 - Mori, T., Sun, X., Kadlcik, S., Janata, J., Abe, I.
Structure-function analysis of the S-glycosylation reaction in lincosamide antibiotics biosynthesis.
Angew. Chem. Int. Ed. 62:e202304989, 2023. DOI:10.1002/anie.202304989 - Ikeda R, Noshiro D, Morishita H, Takada S, Kageyama S, ..., Koga T, Motohashi H, Nakao M, Sakimura K, Horii A, Waguri S, Ichimura Y*, Noda NN*, Komatsu M*.
Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.
EMBO J. 42(14):e113349, 2023. DOI:10.15252/embj.2022113349 - Yamazaki M, Hino S, Usuki S, Miyazaki Y, Oda T, Nakao M, Ito T, Yamagata K
YAP/BRD4-controlled ROR1 promotes tumor-initiating cells and hyperpoliferation in pancreatic cancer.
EMBO J 42:e112614, 2023. DOI:10.15252/embj.2022112614 - Matsumoto S, Harada A, Seta M, Akita M, Gon H, Fukumoto T, Kikuchi A
Wnt Signaling Stimulates Cooperation between GREB1 and HNF4α to Promote Proliferation in Hepatocellular Carcinoma.
Cancer Research 83(14):2312-2327, 2023. DOI:10.1158/0008-5472.CAN-22-3518 - Shogo Sasaki, Yue Ma, Takatsugu Hirokawa, Kazunori Ikebukuro, Masayuki Tera, Kazuo Nagasawa
Regulation of Thrombin Activity by Ligand-Induced Topological Alteration in a Thrombin-Binding Aptamer.
Chem. Commun. 59:8862-8865, 2023. DOI:10.1039/D3CC02308G - Yahiro, T., Kataoka, N., Nakamura, K.
Two ascending thermosensory pathways from the lateral parabrachial nucleus that mediate behavioral and autonomous thermoregulation.
Journal of Neuroscience 43:5221-5240, 2023. DOI:10.1523/JNEUROSCI.0643-23.2023 - Kurusu R#, Fujimoto Y#, Morishita H#, *, Noshiro D, Takada S, ..., Kazuno S, Miura Y, Koike M, Wakai T, Waguri S, Noda NN, Komatsu M*.
Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex.
Dev Cell. 58(13):1189-1205, 2023. DOI:10.1016/j.devcel.2023.04.015 - Matsuura-Suzuki E, Toh H, Iwasaki S
Human-rabbit hybrid translation system to explore the function of modified ribosomes.
Bio Protoc 13(13):e4714, 2023. DOI:10.21769/BioProtoc.4714 - Uchimura H, Kanai K, Arai M, Inoue M, Hishimoto A, Masukawa D, Goshima Y.
Involvement of the L-DOPA receptor GPR143 in acute and chronic actions of methylphenidate.
J Pharmacol Sci 152:178-181, 2023. DOI:10.1016/j.jphs.2023.04.006 - Masukawa D, Takahagi R, Nakao Y, Goshima Y.
L-DOPA Receptor GPR143 Functionally Couples with Adrenergic α1B Receptor at the Second Transmembrane Interface.
Biol Pharm Bull 46:869-873, 2023. DOI:10.1248/bpb.b23-00217 - Kawano, S., Araki, K., Sashida, G., Araki, M., et al.
A gain-of-function mutation in microRNA 142 is sufficient to cause the development of T-cell leukemia in mice.
Cancer Science 114:2821-2834, 2023. DOI:10.1111/cas.15794 - Htun Yinmon, Nakamura Shinji, Nakao Yasuhiro, Mitsuie Tsutomu, Miki Takanori, Ueno Masaki, Kusaka Takashi
Conflicting findings on the effectiveness of hydrogen therapy for ameliorating vascular leakage in a 5-day post hypoxic-ischemic survival piglet model.
Scientific Reports 13:10486, 2023. DOI:10.1038/s41598-023-37577-0 - Fukushi M, Ohsawa R, Okinaka Y, Oikawa D, Kiyono T, Moriwaki M, Irie T, Oda K, Kamei Y, Tokunaga F, Sotomaru Y, Maruyama H, Kawakami H, Sakaguchi T.
Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection.
PLoS One. 18:e0287545, 2023. DOI:10.1371/journal.pone.0287545 - Tsuji, Y., Hara, T., Meng, S., Sato, H., Arao, Y., Ofusa, K., Ishii, H.
Role of RNA methylation in the regulation of pancreatic cancer stem cells.
ONCOLOGY LETTERS 26(2):336, 2023. DOI:10.3892/ol.2023.13922 - Kishimoto H, Iwasaki M, Wada K, Horitani K, Tsukamoto O, Kamikubo K, Nomura S, Matsumoto S, Harada T, Motooka D, Okuzaki D, et al., Kikuchi A, Shiojima I
Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload.
iScience 26(7):107146, 2023. DOI:10.1016/j.isci.2023.107146 - Kito Y, Matsumoto A, Ichihara K, Shiraishi C, Tang R, Hatano A, Matsumoto M, Han P, Iwasaki S, Nakayama KI
The ASC-1 complex promotes translation initiation by scanning ribosomes.
EMBO J 42(12):e112869, 2023. DOI:10.15252/embj.2022112869 - Mori, T., Kadlcik, S., Lyu, S., Kamenik, Z., Sakurada, K., Mazumdar, A., Wang, H., Janata, J., Abe, I.
Molecular basis for carrier protein-dependent amide bond formation in the biosynthesis of lincosamide antibiotics.
Nature Catalysis 6:531-542, 2023. DOI:10.1038/s41929-023-00971-y - Satoshi FUNAYA, Yuan WANG, Masataka G. SUZUKI, Masahito IKAWA, Fugaku AOKI
Involvement of linker histone variant H1a in the regulation of early preimplantation development in mice.
Journal of Reproduction and Development 69:178-182, 2023. DOI:10.1262/jrd.2023-013 - Nobuhiro Okada, Chihiro Ueki, Masahiro Shimazaki, Goki Tsujimoto, Susumu Kohno, Hayato Muranaka, Kiyotsugu Yoshikawa, Chiaki Takahashi
NFYA promotes malignant behavior of triple-negative breast cancer in mice through the regulation of lipid metabolism.
Communications Biology 6:596, 2023. DOI:10.1038/s42003-023-04987-9 - Nakazawa T
Modeling mental disorders in a dish.
Psychiatry Clinical Neuroscience 77:307, 2023. DOI:10.1111/pcn.13552 - Daisuke Tatsuda, Junjiro Yoshida, Tomokazu Ohishi, Manabu Kawada
Pancreatic Stromal Cell-derived Oncostatin M Confers Drug Resistance to a Multi-tyrosine Kinase Inhibitor in Pancreatic Cancer Cells.
Anticancer Res. 43:2477-2489, 2023. DOI:10.21873/anticanres.16415 - Jikuya R, Johnson TA, Maejima K, An J, Ju YS, Lee H, Ha K, Song W, Kim Y, Furuya M, Kato I, Tamura T, Baba M, Linehan WM, Nakagawa H, Hasumi H.
Comparative analyses define differences between BHD-associated renal tumour and sporadic chromophobe renal cell carcinoma.
EBioMedicine 92:104596, 2023. DOI:10.1016/j.ebiom.2023.104596 - Okuda C, Ueda Y, Muroi M, Sanada E, Osada H, Shiono Y, Kimura KI, Takeda K, Kawaguchi K, Kataoka T.
Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells.
J Antibiot 76(6):324-334, 2023. DOI:10.1038/s41429-023-00610-5 - Toshiaki Wayama, Hiroki Oguri*
Synthesis of a Halicyclamine-Type Macrocyclic Scaffold via Biomimetic Transannular Cyclization.
Organic Letters 25(20):3591-3595, 2023. DOI:10.1021/acs.orglett.3c00635 - Horii S, Mori S, .. Nishida R, Kishi S, Sasaki R, Ikemoto A, Owari T, Maesaka F, Honoki K, Miyake M, Tanaka Y, Fujimoto K, Fujiwara-Tani R, Kuniyasu H
5-Aminolevrinic acid exhibits dual effects on stemness in human sarcoma cell lines under dark conditions.
Int J Mol Sci 24:6189, 2023. DOI:10.3390/ijms24076189 - Tanaka M, Homme M, Teramura Y, Kumegawa K, Yamazaki Y, Yamashita K, Osato M, Maruyama R, Nakamura T
HEY1::NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice.
JCI Insight 8(10):e160279, 2023. DOI:10.1172/jci.insight.160279 - Mohamed Darwish, Satoko Hattori, Hirofumi Nishizono, Tsuyoshi Miyakawa, Nozomu Yachie & Keizo Takao
Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency.
Molecular Brain 16(1):44, 2023. DOI:10.1186/s13041-023-01033-x - Fujikawa D., Nakamura T., Yoshioka D., Li Z., Moriizumi H., Taguchi M., Tokai-Nishizumi N., Kozuka-Hata H., Oyama M., Takekawa M.
Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases.
Current Biology 33:1967-1981, 2023. DOI:10.1016/j.cub.2023.04.012 - Takeshi Tsunoda, Hatem A. Abuelizz, Arash Samadi, Chin Piow Wong, Takayoshi Awakawa, Corey J. Brumsted, Ikuro Abe, and Taifo Mahmud
Catalytic Mechanism of Nonglycosidic C–N Bond Formation by the Pseudoglycosyltransferase Enzyme VldE.
ACS Catalysis 13:13369-13382, 2023. DOI:10.1021/acscatal.3c02404 - Kita M, Fujiwara-Tani R, .. Nakashima C, Goto K, Sasaki T, Fujii K, Kawahara I, Bhawal UK, Luo Y, Kuniyasu H
Role of creatine shuttle in colorectal cancer cells.
Oncotarget 24:485-501, 2023. DOI:10.18632/oncotarget.28436 - Kazuhei Niitani, Shiho Ito, Shintaro Wada, Shoma Izumi, Nanoya Nishitani, Satoshi Deyama, Katsuyuki Kaneda
Noradrenergic stimulation of α1 adrenoceptors in the medial prefrontal cortex mediates acute stress-induced facilitation of seizures in mice.
Scientific Reports 13:8089, 2023. DOI:10.1038/s41598-023-35242-0 - Nagao A, Nakanishi Y, Yamaguchi Y, Mishina Y, Karoji M, Toya T, Fujita T, Iwasaki S, Miyauchi K, Sakaguchi Y, Suzuki T
Quality control of protein synthesis in the early elongation stage.
Nat Commun 14(1):2704, 2023. DOI:10.1038/s41467-023-38077-5 - Kagioka T., Itoh S., Hue M.T., Abe M., Hayashi M.
Lithium carbonate accelerates the healing of apical periodontitis.
Scientific Reports 13:7886, 2023. DOI:10.1038/s41598-023-34700-z - Satoshi Zuguchi, Kazuhiro Sakamoto, Norihiro Katayama, Hajime Mushiake
A High-speed Measurement System for Treadmill Spherical Motion in Virtual Reality for Mice and a Robust Rotation Axis Estimation Algorithm Based on Spherical Geometry.
IPSJ Transactions on Bioinformatics 16:1-12, 2023. DOI:10.2197/ipsjtbio.16.1 - Fujiwara-Tani R, Mori S, Ogata R, Sasaki R, Ikemoto A, Kishi S, Kondoh M, Kuniyasu H
Claudin-4: A New Molecular Target for Epithelial Cancer Therapy.
Int J Mol Sci 24(6):5494, 2023. DOI:10.3390/ijms24065494 - Nemeth T, Yoshizawa-Sugata N, Pallier A, Tajima Y, Tóth É, *Masai H, * Yamakoshi Y
Water-Soluble Gd(III)-Porphyrin Complexes Capable of Both Photosensitization and Relaxation Enhancement.
Chemical & Biomedical Imaging 1:157-167, 2023. DOI:10.1021/cbmi.3c00007 - Distefano, R., Ilieva, M., Madsen, J.H., Ishii, H., Aikawa, M., Rennie, S., Uchida, S.
T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes.
Non-Coding RNA 9(3):30, 2023. DOI:10.3390/ncrna9030030 - Hanna Deguchi-Horiuchi, Sawako Suzuki, Eun Young Lee, Takashi Miki, Noriko Yamanaka, Ichiro Manabe, Tomoaki Tanaka, Koutaro Yokote
Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia.
Scientific reports 13:7291-7291, 2023. DOI:10.1038/s41598-023-34336-z - Ushimaru, R., Lyu, J., Ling, M., Abe, I.
Multiple C–C bond cleavage reactions catalyzed by tolyporphin tetrapyrrole biosynthetic enzymes.
J. Am. Chem. Soc. 145:9834-9839, 2023. DOI:10.1021/jacs.3c01993 - Setogawa S, 11 名, Osanai M, Sekiguchi H, Ohkawa N
A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice.
Molecular Brain 16:38, 2023. DOI:10.1186/s13041-023-01019-9 - Ikutama R, Peng G, Tsukamoto S, Umehara Y, Trujillo-Paez JV, Yue H, Nguyen HLT, Takahashi M, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F.
Cathelicidin LL-37 Activates Human Keratinocyte Autophagy through the P2X₇, Mechanistic Target of Rapamycin, and MAPK Pathways.
J Invest Dermatol. 143(5):751-761, 2023. DOI:10.1016/j.jid.2022.10.020 - Nakamichi R, Hishikawa A, Chikuma S, Hayashi K, Itoh H et al
DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation.
Cell Reports 42:112302, 2023. DOI:10.1016/j.celrep.2023.112302 - Shiraishi C,Matsumoto A,Ichihara K,Yamamoto T,Yokoyama T,Mizoo T,Hatano A,Matsumoto M,Tanaka Y,Matsuura-Suzuki E,Iwasaki S,Matsushima S,Tsutsui H,Nakayama KI
RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function.
Nat Commun 14(1):2131, 2023. DOI:10.1038/s41467-023-37838-6 - Takagi T, Fujiwara-Tani R, .. Sasaki T, Ogata R, Ikemoto A, Sasaki R, Ohmori H, Luo Y, Bhawal UK, Sho M, Kuniyasu H
Lauric acid overcomes hypoxia-induced gemcitabine chemoresistance in pancreatic ductal adenocarcinoma.
Int J Mol Sci 24:7506, 2023. DOI:10.3390/ijms24087506 - Atsushi Noritake, Kae Nakamura
Rewarding-unrewarding prediction signals under a bivalent context in the primate lateral hypothalamus.
Scientific Reports 13:5926, 2023. DOI:10.1038/s41598-023-33026-0 - Masukawa D, Kitamura S, Tajika R, Uchimura H, Arai M, Takada Y, Arisawa T, Otaki M, Kanai K, Kobayashi K, Miyazaki T, Goshima Y.
Coupling between GPR143 and dopamine D2 receptor is required for selective potentiation of dopamine D2 receptor function by L-3,4-dihydroxyphenylalanine in the dorsal striatum.
J Neurochem 165(2):177-195, 2023. DOI:10.1111/jnc.15789 - Mori S, Fujiwara-Tani R, Gyoten M, Nukaga S, Sasaki R, Ikemoto A, Ogata R, Kishi S, Fujii K, Luo Y, Kuniyasu H
Berberine induces combined cell death in gastrointestinal cell lines.
Int J Mol Sci 24:6588, 2023. DOI:10.3390/ijms24076588 - Nagoya A, Sada R, Kimura H, Yamamoto H, Morishita K, Miyoshi E, Morii E, Shintani Y, Kikuchi A
CKAP4 is a potential exosomal biomarker and a therapeutic target for lung cancer.
Trans. Lung Cancer Res 12(3):408-426, 2023. DOI:10.21037/tlcr-22-571 - Ryo Endo, Yi-Kai Chen, John Burke, Noriko Takashima1, Nayan Suryawanshi, Kelvin K. Hui, Tatsuhiko Miyazaki, Motomasa Tanaka
Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3.
Proc Natl Acad Sci U S A 120:e2211522120, 2023. DOI:10.1073/pnas.2211522120 - Hamada S, Mikami K, Ueda S, Nagase M, Bito H, Takemoto-Kimura S, Watabe AM et al.
Experience-dependent changes in affective valence of taste in male mice.
Molecular brain 16(1):28, 2023. DOI:10.1186/s13041-023-01017-x - Soh JEC, Shimizu A, Molla MR, Zankov DP, Nguyen LKC, Khan MR, Tesega WW, Chen S, Tojo M, Ito Y, Sato A, Hitosugi M, Miyagawa S, Ogita H
RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy.
J Biol Chem. 299:102993, 2023. DOI:10.1016/j.jbc.2023.102993 - Nago-Iwashita, Y., Moriya, Y., Hara, S., Ogawa, R., Aida, R., Miyajima, K., Shimura, T., Muramatsu, S.I., Ide, S., Ikeda, K., Ichinose, H.
Overexpression of tyrosine hydroxylase in dopaminergic neurons increased sensitivity to methamphetamine.
Neurochemistry International 164:105491, 2023. DOI:10.1016/j.neuint.2023.105491 - Ushimaru, R., Lyu, J., Abe, I.
Diverse enzymatic chemistry for propionate side chain cleavages in tetrapyrrole biosynthesis.
J. Ind. Microbiol. Biotechnol. 50:kuad016, 2023. DOI:10.1093/jimb/kuad016 - 吉田知之
シナプスオーガナイザーPTPδによるシナプス形成調節の分子機構.
生体の科学 74(1):5, 2023. - Manabu Abe, Ena Nakatsukasa, Rie Natsume, Shun Hamada, Kenji Sakimura, Ayako M Watabe, Toshihisa Ohtsuka
A novel technique for large-fragment knock-in animal production without ex vivo handling of zygotes.
Scientific Reports 13:2245, 2023. DOI:10.1038/s41598-023-29468-1 - Fujiwara-Tani R, Takagi T, Mori S, Kishi S, Nishiguchi Y, Sasaki T, Ikeda M, Nagai K, Bhawal UK, Ohmori H, Fujii K, Kuniyasu H
Short telomere lesions with dysplastic metaplasia histology may represent precancerous lesions of Helicobacter pylori-positive gastric mucosa.
Int J Mol Sci 24:3182, 2023. DOI:10.3390/ijms24043182 - Oikawa D, Shimizu K, Tokunaga F.
Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1.
Antioxidants (Basel). 12:350, 2023. DOI:10.3390/antiox12020350 - Cheung A, Konno K, Imamura Kawasawa Y, Matsui A, Abe M, Sakimura K, Sasaoka T, Uemura T, Watanabe M, and Futai K
Neurexins in serotonergic neurons regulate serotonin transmission and complex mouse behaviors.
eLife 12:e85058, 2023. DOI:10.7554/eLife.85058 - Fumito Ishibashi, Shijiao Zha, Taiyo Kondo, Mayu Sakamoto, Mikinori Ueno, Tsutomu Fukuda
Synthesis and structure-activity relationship study of aldose reductase inhibiting marine alkaloid lukianol A and its derivatives.
Bioscience, Biotechnology, and Biochemistry 87:148-157, 2023. DOI:10.1093/bbb/zbac193 - Sato Y, Terawaki S, Oikawa D, Shimizu K, Okina Y, Ito H, Tokunaga F.
Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer's disease and amyotrophic lateral sclerosis.
Front Mol Biosci. 10:1089213, 2023. DOI:10.3389/fmolb.2023.1089213 - Sagae Y, Horie A, Yanai A, Ohara T, Nakakita B, Kitawaki Y, Okunomiya A, Tani H, Yamaguchi K, Hamanishi J, Lydon JP, Daikoku T, Watanabe H, Mandai M.
Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth.
Matrix Biology 115:16-31, 2023. DOI:10.1016/j.matbio.2022.11.004
2022年度
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Roles of immune molecules in the formation of the cerebral cortex and their abnormalities in psychiatric disorders.
DOHad Research 2023;11(2):126-134. DOI:10.51067/dohad.11.2_126 - Miyake T., Inoue Y., Shao X., Seta T., Aoki Y., Nguyen Pham K.T., Shichino Y., Sasaki J., Sasaki T., Ikawa M., Yamaguchi Y., Okamura H., Iwasaki S., Doi M.
Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm.
Cell Reports 2023;42(3):112157. DOI:10.1016/j.celrep.2023.112157 - Takemoto T, Hashimoto R, et al.
Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.
Molecular Brain 2023;15:34:126-134. DOI:10.1186/s13041-022-00915-w - Yasuhiro Suzuki, Chihiro Nakamoto, Izumi Watanabe-Iida, Masahiko Watanabe, Tomonori Takeuchi, Toshikuni Sasaoka, Manabu Abe, Kenji Sakimura.
Quantitative analysis of NMDA receptor subunits proteins in mouse brain.
Neurochemistry International 2023;165:105517. DOI:10.1016/j.neuint.2023.105517 - Hirohito Esaki, Yuki Sasaki, Naoya Nishitani, Hikari Kamada, Satoko Mukai, Yoshitaka Ohshima, Sao Nakada, Xiyan Ni, Satoshi Deyama, Katsuyuki Kaneda.
Role of 5-HT1A receptors in the basolateral amygdala on 3,4-methylenedioxymethamphetamine-induced prosocial effects in mice.
European journal of pharmacology 2023;946:175653. DOI:10.1016/j.ejphar.2023.175653 - Iguchi K, Sada R, Matsumoto S, Kimura H, Zen Y, Akita M, Gon H, Fukumoto T, Kikuchi A.
DKK1-CKAP4 signal axis promotes hepatocellular carcinoma aggressiveness.
Cancer Science 2023;114(5):2063-2077. DOI:10.1111/cas.15743 - Kitakaze, M., Hara, T., Hirai, T., Okuzaki, D., Sekido, Y., Hata, T., Ogino, T., Takahashi, H., Miyoshi, N., Ofusa, K., Eguchi, H., Doki, Y., Ishii, H.
Cancer-specific tissue-resident memory T-cells in colorectal cancer.
Br J Cancer 2023;128(10):1828-1837. DOI:10.1038/s41416-023-02202-4 - Furukawa T, Tabata S, Minami K, Yamamoto M, Kawahara K, Tanimoto A.
Metabolic reprograming of cancer as a therapeutic target.
Biochim Biophys Acta Gen Subj 2023;1867(3):130301. DOI:10.1016/j.bbagen.2022.130301 - Ueda J, Yamazaki T, Funakoshi H.
Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges.
Int J Mol Sci. 2023;24(5):4778. DOI:10.3390/ijms24054778 - Pagano R, Salamian A, Zielinski J, .., Bito H, Muller CP, Schumann G, Okuno H, Radwanska K.
Arc controls alcohol cue relapse by a central amygdala mechanism.
Mol Psychiatry 2023;28(2):733-745. DOI:10.1038/s41380-022-01849-4 - Chen M, Kumakura N, Saito H, Muller R, Nishimoto M, Mito M, Gan P, Ingolia NT, Shirasu K, Ito T, Shichino Y, and Iwasaki S.
A parasitic fungus employs mutated eIF4A to survive on rocaglate-synthesizing Aglaia plants.
eLife 2023;12:e81302. DOI:10.7554/eLife.81302 - Toyokuni S, Kong Y, Zheng H, Maeda Y, Katabuchi M, Motooka Y.
Three-dimensional regulation of ferroptosis at the intersection of iron, sulfur and oxygen executing scrap and build toward evolution.
Antioxidants and Redox Signaling 2023;Online Ahead of Print. DOI:10.1089/ars.2022.0142 - Yoneda T, Hayashi K, Yoshimura Y.
Experience-dependent functional plasticity and visual response selectivity of surviving subplate neurons in the mouse visual cortex.
PNAS 2023;120(9):e2217011120. DOI:10.1073/pnas.2217011120 - Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Onodera O, Iwakura Y, Nawa H, Komatsu M, Fujii M.
USP10 inhibits aberrant cytoplasmic aggregation of TDP-43 by promoting stress granule clearance.
Mol Cell Biol. 2023;42(3):e0039321. DOI:10.1128/MCB.00393-21 - Awakawa T, Liu W, Bai T, Taniguchi T, Abe I.
Orthoester formation in fungal meroterpenoid austalide F biosynthesis.
Phil. Trans. R. Soc. B 2023;378(1871):20220037. DOI:10.1098/rstb.2022.0037 - Yamashita A, Shichino Y, Fujii K, Koshidaka Y, Adachi M, Sasagawa E, Mito M, Nakagawa S, Iwasaki S, Takao K, Shiina N.
ILF3 prion-like domain regulates gene expression and fear memory under chronic stress.
iScience 2023;26(3):06229. DOI:10.1016/j.isci.2023.106229 - Yasuyo Ohguchi, Hiroto Ohguchi.
DIS3: The Enigmatic Gene in Multiple Myeloma.
International Journal of Molecular Sciences 2023;24(4):4079. DOI:10.3390/ijms24044079 - Shinji Kishimoto, Ayumi Minami, Yoshimitsu Aoki, Yuya Matsubara, Shogo Watanabe and Kenji Watanabe.
Reactive Azlactone Intermediate Drives Fungal Secondary Metabolite Cross-Pathway Generation.
Journal of the American Chemical Society 2023;145(5):3221-3228. DOI:10.1021/jacs.2c13188 - Yutaka Kanoh, Masaru Ueno, Motoshi Hayano, Satomi Kudo, Hisao Masai.
Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect.
Life Science Alliance 2023;6(4):e202201603 DOI:10.26508/lsa.202201603 - Saito H, Osaki T, Ikeuchi Y, and Iwasaki S.
High-throughput assessment of mitochondrial protein synthesis in mammalian cells using mito-FUNCAT FACS.
Bio Protoc. 2023;13(3):e4602. DOI:10.21769/BioProtoc.4602 - Kyosuke Mukae, Hisanori Takenobu, Yuki Endo, Michinori Funato, Junya Toguchida, Kenji Osafune, Tatsutoshi Nakahata, Hiroaki Kanda, Takehiko Kamijo.
Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell-derived neural crest cells.
Cancer Science 2023;114(5):1898-1911. DOI:10.1111/cas.15730 - Luo Y, Akatsuka S, Motooka Y, Kong Y, Zheng H, Mashimo T, Imaoka T, Toyokuni S.
BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile-induced mesothelioma via ferroptosis-resistance.
Cancer Science 2023;114(4):1423-1436. DOI:10.1111/cas.15705 - Masami Ishido.
Chemical nature of attention deficit hyperactivity disorder (ADHD) - related chemical subfamily.
Chemosphere 2023;313:137495. DOI:10.1016/j.chemosphere.2022.137495 - Chi-Chun Yang, Hisao Masai.
Claspin is Required for Growth Recovery from Serum Starvation through Regulating the PI3K-PDK1-mTOR Pathway in Mammalian Cells.
Mol Cell Biol. 2023;43:1-21. DOI:10.1080/10985549.2022.2160598 - Ohta S, Misawa A, Thu C, Hirose Y, Matsumoto N, Kawakami Y.
Melanoma antigens recognized by T cells and their use for immunotherapy.
Experimental Dermatology 2023;32(3):297-305. DOI:10.1111/exd.14741 - Shinji Nakamura, Yasuhiro Nakao, Yinmon Htun, .., Masaki Ueno, Takashi Kusaka.
Impact of hydrogen gas inhalation during therapeutic hypothermia on cerebral hemodynamics and oxygenation in the asphyxiated piglet.
Scientific Report 2023;13:1615. DOI:10.1038/s41598-023-28274-z - Yasuto Takeuchi, Noriko Gotoh.
Inflammatory cytokines-enriched microenvironment plays key roles for the development of breast cancers.
Cancer Science 2023;114(5):1792-1799. DOI:10.1111/cas.15734 - Shin YH, Im JH, Awakawa T, Abe I, Moore BS, Fenical W, Yoon YJ, Cho JC, Lee SK, Oh KB, Oh DC.
Genomic and Spectroscopic Signature-Based Discovery of Natural Macrolactams.
J Am Chem Soc. 2023;145(3):1886-1896. DOI:10.1021/jacs.2c11527 - Awakawa T, Mori T, Ushimaru R, Abe I.
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis.
Nat Prod Rep. 2023;40(1):46-61. DOI:10.1039/d2np00014h - Cheung A, Konno K, Imamura Kawasawa Y, Matsui A, Abe M, Sakimura K, Sasaoka T, Uemura T, Watanabe M, and Futai K.
Neurexins in serotonergic neurons regulate serotonin transmission and complex mouse behaviors.
eLife 2023;12:e85058. DOI:10.7554/eLife.85058 - Kurihara, Y, Kotone M, Nagi M, Shoji, H, Miyakawa, T, and Shirane, M.
PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain.
Molecular Brain 2023;16(1):11. DOI:10.1186/s13041-023-01002-4 - Kei-ichiro Ishiguro.
Chapter One - Mechanism of initiation of meiosis in mouse germ cells.
Current Topics in Developmental Biology 2023;151:1-26. DOI:10.1016/bs.ctdb.2022.04.005 - Masanori Fujimoto, Yutaro Ruike, Kazuki Ishiwata, Kumiko Naito, Akiko Ishida, Masaya Koshizaka, Sawako Suzuki, Yuki Shiko, Hisashi Koide, Koutaro Yokote.
Antihypertensive Effects of Esaxerenone in Older Patients with Primary Aldosteronism.
International journal of hypertension 2023;6453933. DOI:10.1155/2023/6453933 - Toyokuni S, Kong Y, Motooka Y, Akatsuka S.
Environmental impact on carcinogenesis under BRCA1 haploinsufficiency.
Genes and Environment 2023;45:2. DOI:10.1186/s41021-023-00258-5 - Tran Nguyen Truc L, Matsuda S, Takenouchi A, Tran Thuy Huong Q, Kotani Y, Miyazaki T, Kanda H, Yoshizawa K, Tsukaguchi H.
Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons.
Scientific Reports 2023;13:508. DOI:10.1038/s41598-023-27766-2 - Moriya M, Kasahara Y, Shimada M, Sakakibara Y, Fujii H, Nagase H, Ide S, Ikeda K, Hall FS, Uhl GR, Sora I.
Role for µ-opioid receptor in antidepressant effects of ∂-opioid receptor agonist KNT-127.
Journal of Pharmacological Sciences 2023;15(3):135-141. DOI:10.1016/j.jphs.2022.12.008 - Hao-Wen Hsiao, Chi-Chun Yang, Hisao Masai.
Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses.
Biomolecules 2023;13:125. DOI:10.3390/biom13010125 - 石黒啓一郎
数分裂プログラムの制御における雌雄性差
日本内分泌学会雑誌 2023;27:28-32 - Kazuhide Miyamoto, Hodaka Hayabuchi, Yukiko Tokifuji, Makoto Ando, Nobuyuki Onishi, Tadashi Okamura, Akihiko Yoshimura, Shunsuke Chikuma.
A Protein Kinase D Inhibitor Suppresses AKT on T cells and Antagonizes Cancer Immunotherapy by Anti-PD-1.
International Immunology 2022;34(12):609-619. DOI:10.1093/intimm/dxac035 - Miyao S, Saito K, Oshima R, Kawahara K, Nagahama M.
MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing.,Biochem Biophys Res Commun.
2022;637:203-209. DOI:10.1016/j.bbrc.2022.11.018 - Takashi Nagashima, Suguru Tohyama, Kaori Mikami, Masashi Nagase, Mieko Morishima, Atsushi Kasai, Hitoshi Hashimoto, Ayako M Watabe.
Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.
Nature Communications 2022;13:7913. DOI:10.1038/s41467-022-35634-2 - 岩崎信太郎、吉田稔
スプライシング阻害と翻訳制御
Journal of Japanese Biochemical Society 2022;94(6):819-828. DOI:10.14952/SEIKAGAKU.2022.940819 - Nakamura, Y., Yahiro, T., Fukushima, A., Kataoka, N., Hioki, H., Nakamura, K.
Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling.
Science Advances 2022;8(51):eadd5463. DOI:10.1126/sciadv.add5463 - Yoshimatsu S, Nakajima M, Sonn I, Natsume R, Sakimura K, Nakatsukasa E, Sasaoka T, Nakamura M, Serizawa T, Sato T, Sasaki E, Deng H, Okano H.
Attempts for deriving extended pluripotent stem cells from common marmoset embryonic stem cells.
Genes to Cells 2022;28(2):156-169. DOI:10.1111/gtc.13000 - Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, .., Sakimura K, .., Komatsu M.
The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.
Nature communications 2022;13:7857. DOI:10.1038/s41467-022-35501-0 - Ishihara Y, Nakamura K, Nakagawa S, Okamoto Y, Yamamoto M, Furukawa T, Kawahara K.
Nucleolar Stress Response via Ribosomal Protein L11 Regulates Topoisomerase Inhibitor Sensitivity of P53-Intact Cancers.
Int J Mol Sci. 2022;23(24):15986. DOI:10.3390/ijms232415986 - Yoshizawa T, Sato Y, Sobuz S, Mizumoto T, Tsuyama T, Karim Md, Miyata K, Tasaki M, Yamazaki M, Kariba Y, Braun T, Bober E., Auwerx J, Yamagata K.
SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice.
Nature Communications 2022;13:7439. DOI:10.1038/s41467-022-35219-z - Hisao Masai.
Replicon hypothesis revisited.
Biochemical and Biophysical Research Communications 2022;633:77-80. DOI:10.1016/j.bbrc.2022.09.060 - Saito R, Tada Y, Oikawa D, Sato Y, Seto M, Satoh A, Kume K, Ueki N, Nakashima M, Hayashi S, Toyoshima Y, Tokunaga F, Kawakami H, Kakita A.
Spinocerebellar ataxia type 17-digenic TBP/STUB1 disease: neuropathologic features of an autopsied patient.
Acta Neuropathol Commun. 2022;10,:77. DOI:10.1186/s40478-022-01486-6 - Daikohara K, Akanuma SI, Kubo Y, Hosoya KI.
Lipopolysaccharide-Induced Functional Alteration of P-glycoprotein in the Ex Vivo Rat Inner Blood-Retinal Barrier.
Int. J. Mol. Sci. 2022;23(24):15504. DOI:10.3390/ijms232415504 - Li X, Chen HP, Zhou L, Fan J, Awakawa T, Mori T, Ushimaru R, Abe I, Liu JK.
Cordycicadins A-D, Antifeedant Polyketides from the Entomopathogenic Fungus Cordyceps cicadae JXCH1.
Org Lett. 2022;24(47):8627-8632. DOI:10.1021/acs.orglett.2c03432 - Abe M., Saeki N., Ikeda Y., Ohba S.
Kruppel-Like Factors in skeletal physiology and pathologies.
Int J Mol Sci. 2022;23(23):15174. DOI:10.3390/ijms232315174 - Rahman SMK, Hussain Z, Morito K, Takahashi N, Sikder MM, Tanaka T, Ohta KI, Ueno M, Takahashi H, Yamamoto T, Murakami M, Uyama T, Ueda N.
Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A 2 ε in an ex vivo murine model of brain ischemia.
Biochim. Biophys. Acta Mol. Cell Biol. Lipds 2022;1867(12):159222. DOI:10.1016/j.bbalip.2022.159222 - Terada K, Nakamura S, Nakao Y, Fukudome K, Miyagi Y, Onishi T, Kusaka T.
Cerebral hemoglobin oxygenation in children with congenital heart disease.
Pediatr Int. 2022;64:e14726. DOI:10.1111/ped.14726 - Morishita H, Komatsu M.
Role of autophagy in liver diseases.
Current Opinion in Physiology 2022;30:100594. DOI:10.1016/j.cophys.2022.100594 - Zhang Doudou, Takashi Shimokawa, Qianqian Guo, Shingo Dan, Yoshio Miki, Shigeaki Sunada.
Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break.
Cancer Science 2022;114(3):1108-1117. DOI:10.1111/cas.15659 - Sakai D, Tomita H, Maeda A.
Optogenetic Therapy for Visual Restoration.
International Journal of Molecular Sciences 2022;23(23):15041. DOI:10.3390/ijms232315041 - Tao H, Ushimaru R, Awakawa T, Mori T, Uchiyama M, Abe I.
Stereoselectivity and Substrate Specificity of the Fe(II)/α Ketoglutarate-Dependent Oxygenase TqaL.
J Am Chem Soc. 2022;144(47):21512-21520. DOI:10.1021/jacs.2c08116 - Matsusaka H, Tao W, Furuya K, Yamada-Kato T, Bai L, Tomita H, Sugano E, Ozaki T, Kiyono T, Fukuda T.
Comprehensive transcriptome data to identify downstream genes of testosterone signalling in dermal papilla cells.
Scientific Data 2022;9:731. DOI:10.1038/s41597-022-01846-w - Daisuke Hoshi, Emiri Kita, Yoshiaki Maru, Hiroyuki Kogashi, Tetsuo Ushiku, Masashi Fukayama, Makiko Itami, Taketo Yamaguchi, Yoshitaka Hippo.
Derivation of pancreatic acinar cell carcinoma cell line HS-1 as a patient-derived tumor organoid.
Cancer Science 2022;114(3):1165-1179. DOI:10.1111/cas.15656 - Alexis J Haas, Ceniz Zihni, Susanne M Krug, Riccardo Maraspini, Tetsuhisa Otani, Mikio Furuse, Alf Honigmann, Maria Balda, Karl Matter.
ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions.
Cells 2022;11(23):3775. DOI:10.3390/cells11233775 - Terayama R, Ishikawa T, Ishiwata K, Sato A, Minamizuka T, Ohno T, Kono S, Yamamoto M, Yokoh H, Nagano H, Koshizaka M, Suzuki S, Koide H, Maezawa Y, Yokote K.
Correction of Hypercortisolemia with an Improved Cognitive Function and Muscle Mass after Transsphenoidal Surgery in an Older Patient with Cushing's Disease: A Case Report.
Intern Med. 2022;61(22):3391-3399. DOI:10.2169/internalmedicine.8326-21 - Showkat Rashid; Takashi Murakami; Hiroshi Koganezawa; Yusuke Yoshigoe; Shoichi Hosoya; Shinichi Saito.
Fluorinated [2]rotaxanes with spirofluorene motifs: a non-symmetric distribution of the ring component along the axle component.
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Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2.
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Depletion of R270C mutant p53 in osteosarcoma attenuates cell growth but does not prevent invasion and metastasis in vivo.
Cells 2022;11(22):3614. DOI:10.3390/cells11223614 - Mizumoto T, Yoshizawa T, Sato Y, Ito T, Tsuyama T, Satoh A, Araki S, Tsujita K, Tamura M, Oike Y, Yamagata K.
SIRT7 deficiency protects against aging-associated glucose intolerance and extends lifespan in male mice.
Cells 2022;11(22):3609. DOI:10.3390/cells11223609 - Yoshigoe Y, Hashizume K, Saito S.
Synthesis and stereochemistry of chiral aza-boraspirobifluorenes with tetrahedral boron-stereogenic centers.
Dalton Transactions 2022;51(44):17035-17039. DOI:10.1039/D2DT03303H - Sato, H., Hara, T., Tatekawa, S., Sasaki, K., Kobayashi, S., Kitagawa, T., Doki, Y., Eguchi, H., Ogawa, K., Uchida, S., Ishii, H.
Emerging roles of long noncoding and circular RNAs in pancreatic ductal adenocarcinoma.
Front. Physiol. 2022;13:1025923. DOI:10.3389/fphys.2022.1025923 - Jin M., Matsumoto S., Ayaki T., Takahashi R., Takao T. and Hirotsune S.
DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers.
Nature Communications 2022;13(1):6880. DOI:10.1038/s41467-022-34555-4 - Chikara Takeuchi, Moe Yokoshi, Shu Kondo, Aoi Shibuya, Kuniaki Saito, Takashi Fukaya, Haruhiko Siomi, Yuka W Iwasaki.
Mod(mdg4) variants repress telomeric retrotransposon HeT-A by blocking subtelomeric enhancers.
Nucleic Acids Research 2022;50(20):11580-11599. DOI:10.1093/nar/gkac1034 - Ohmori I, Ouchida M, Imai H, Ishida S, Toyokuni S, Mashimo T.
Thioredoxin deficiency increases oxidative stress and causes bilateral symmetrical degeneration in rat midbrain.
Neurobiology of Disease 2022;175:105921. DOI:10.1016/j.nbd.2022.105921 - Komatsu M.
p62 bodies: phase separation, NRF2 activation, and selective autophagic degradation.
IUBMB Life 2022;74(12):1200-1208. DOI:10.1002/iub.2689 - Shinozaki Y, Leung A, Koizumi S et al.
Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy.
Sci Adv. 2022;8 (44) :eabq1081. DOI:10.1126/sciadv.abq1081 - Sekido, T., Yamamoto, K., Yanagita, R. C., Kawamani, Y., Hanaki, Y., Irie, K.
A simplified analog of debromoaplysiatoxin lacking the B-ring of spiroketal moiety retains protein kinase C-binding and antiproliferative activities.
Bioorganic & Medicinal Chemistry 2022;73:116988. DOI:10.1016/j.bmc.2022.116988 - Hayashi T.
Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation.
Frontiers in Synaptic Neuroscience 2022;14:921772. DOI:10.3389/fnsyn.2022.921772 - 中村加枝, 石井宏憲, 安田正治
様々な視点から意思決定を考察する 薬理学的な視点から
月刊精神科 (精神科) 2022;41(4):500-507. - Sato, H., Sasaki, K., Hara, T., Kobayashi, S., Doki, Y., Eguchi, H., Satoh, T., Ishii, H.
Targeting the regulation of aberrant protein production pathway in gastrointestinal cancer treatment.
Frontiers in Oncology 2022;12:1018333. DOI:10.3389/fonc.2022.1018333 - Aoyama M, Ishikawa K, Nemoto S, Hirano H, Watanabe N, Osada H, Watanabe S, Semba K.
Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells.
Journal of Biological Chemistry 2022;298(12):102635. DOI:10.1016/j.jbc.2022.102635 - Nakagawa S, Kawahara K*, Okamoto Y*, Kodama Y, Nishikawa T, Kawano Y and Furukawa T.
Association between Dysfunction of the Nucleolar Stress Response and Multidrug Resistance in Pediatric Acute Lymphoblastic Leukemia.
Cancers 2022;14(20):5127. DOI:10.3390/cancers14205127 - Park SW, Jeon P, Yamasaki A, Lee HE, Choi H, Mun JY, Jun YW, Park JH, Lee SH, Lee SK, Lee YK, Song HK, Lazarou M, Cho DH, Komatsu M, Noda NN, Jang DJ, Lee JA.
Development of new tools to study membrane-anchored mammalian Atg8 proteins.
Autophagy 2022;19(5):1424-1443. DOI:10.1080/15548627.2022.2132040 - Sato, H., Sasaki, K., Hara, T., Kobayashi, S., di Luccio, E., Hirotsu, T., Doki, Y., Eguchi, H., Satoh, T., Uchida, S., Ishii, H. et al.
Pancreatic Cancer Research beyond DNA Mutations.
Biomolecules 2022;12(10):1503. DOI:10.3390/biom12101503 - Sakaguchi M, Okagawa S, Okubo Y, Otsuka Y, Fukuda K, Igata M, Kondo T, Sato Y, Yoshizawa T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, Araki E.
Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.
Nature Communications 2022;13:6092. DOI:10.1038/s41467-022-33842-4 - Molla MR, Shimizu A, Komeno M, Rahman NIA, Soh JEC, Nguyen LKC, Khan MR, Tesega WW, Chen S, Pang X, Tanaka-Okamoto M, Takashima N, Sato A, Suzuki T, Ogita H.
Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity.
Commun Biol. 2022;5:1071. DOI:10.1038/s42003-022-04042-z - Hamada Y, Sasaki L, Uehara H, Suzuki T, Kinoshita S, Otsuka K, Kihara A, Yamaguchi Y, Miyake T, Doi M.
Optimising the method for visualising mouse meibomian gland using eyelid whole-mount lipid staining.
Ocul. Surf. 2022;26:268-270. DOI:10.1016/j.jtos.2022.10.002 - Maruta T, Hidaka K, Kouroki S, Koshida T, Kurogi M, Kage Y, Mizuno S, Shirasaka T, Yanagita T, Takahashi S, Takeya R, Tsuneyoshi I.
Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli.
PLoS One 2022;17(10):e0275751. DOI:10.1371/journal.pone.0275751 - Kyota Aoyagi, Manabu Abe, Kenji Sakimura, Tomotake Kanki, Mica Ohara-Imaizumi et al.
A new beta cell-specific mitophagy reporter mouse shows that metabolic stress leads to accumulation of dysfunctional mitochondria despite increased mitophagy.
Diabetologia 2022;66:147-162. DOI:10.1007/s00125-022-05800-8 - Yoshida, J., Takayama, K., Kawada, M.
Short peptide derived from hGAPDH exhibit anti-cancer activity.
Bioorg. Med. Chem. 2022;71:116953. DOI:10.1016/j.bmc.2022.116953 - 吉田穂波.
頼るスキルと子育て : 「受援力」を磨き,子育ての味方を増やす—特集 子どもを育てる 親子が育つ : 時代がかわっても大事にしたいこと
チャイルドヘルス 2022;25(10):760-764 - Yoshizato K, Taira T, Sato-Matsubara M, .., Oikawa D, Matsubara T, Nakagama Y, Kido Y, Tokunaga F, Ikeda K, Kaneko A, Kawada N.
Cloaking the ACE2 receptor with salivary cationic proteins inhibits SARS-CoV-2 entry.
J Biochem. 2022;172(4):205-216. DOI:10.1093/jb/mvac054 - Hirose W, Oshikiri H, Taguchi K, Yamamoto M.
The KEAP1-NRF2 system and esophageal cancer.
Cancers 2022;14(19):4702. DOI:10.3390/cancers14194702 - 齊藤奈英、板倉誠、田井中一貴, Tom Macpherson, 疋田貴俊、山口瞬、佐藤朝子、大久保直、知見聡美、南部篤、笹岡俊邦
D1およびD2ドーパミン受容体を介する神経伝達による運動制御と学習記憶の仕組みの理解
日本生物学的精神医学会誌 2022;33(3):100-105. DOI:10.11249/jsbpjjpp.33.3_100 - Hashimoto R, Takahashi J, Shirakura K, Funatsu R, Kosugi K, Deguchi S, Yamamoto M, Tsunoda Y, Morita M, .., Takayama K, Okada Y.
SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.
Science Advances 2022;8(38):eabo6783. DOI:10.1126/sciadv.abo6783 - Nakazawa S, Mamiya R, Kawabata-Iwakawa R, Oikawa D, Kaira K, Tokunaga F, Nobusawa S, Sato Y, Sasaki A, Yajima T, Shirabe K.
Identification and molecular analysis of RNF31 Q622H germline polymorphism.
Oncol Lett. 2022;24(5):394. DOI:10.3892/ol.2022.13514 - Fukushima, A., Kataoka, N., Nakamura, K.
An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow.
Cell Reports 2022;40(12):111380. DOI:10.1016/j.celrep.2022.111380 - Yamamoto Y, Akanuma SI, Kon H, Endo H, Kubo Y, Hosoya KI.
Newly-established in vitro inner BRB spheroids to elucidate retinal Ang2-linked substance transfer.
J. Control. Release 2022;351:8-21. DOI:10.1016/j.jconrel.2022.09.019 - Suzuki S, Venkatesh D, Kanda H, Nakayama A, Hosokawa H, Lee E, Miki T, Stockwell BR, Yokote K, Tanaka T, Prives C.
GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma.
Cancer Res. 2022;82(18):3209-3222. DOI:10.1158/0008-5472.CAN-21-3914 - Yokomizo T, Ideue T, Morino-Koga S, Tham CY, Sato T, Takeda N, Kubota Y, Kurokawa M, Komatsu N, Ogawa M, Araki K, Osato M, Suda T.
Independent origins of fetal liver haematopoietic stem and progenitor cells.
Nature 2022;609 (7928):779-784. DOI:10.1038/s41586-022-05203-0 - Shengming Wang, Yu Fu, Takaki Miyata, Sakiko Matsumoto, Tomoyasu Shinoda, Kyoko Itoh, Akihiro Harada, Shinji Hirotsune and Mingyue Jin.
Functional Cooperation of α-Synuclein and Tau Is Essential for Proper Corticogenesis.
Journal of Neuroscience 2022;42(37):7031-7046. DOI:10.1523/JNEUROSCI.0396-22.2022 - Kai R, Takahashi K, Tainaka K, Iwakura Y, Namba H, Saito N, Sasaoka T, Yamaguchi S, Nawa H, Horii A.
Cerebrocortical activation following unilateral labyrinthectomy in mice characterized by whole-brain clearing: implications for sensory reweighting.
Scientific Reports 2022;12:15424. DOI:10.1038/s41598-022-19678-4 - Nakashima C, Fujiwara-Tani R, Mori S, Kishi S, Ohmori H, Fujii K, Mori T, Miyagawa Y, Yamamoto K, Kirita T, Luo Y, Kuniyasu H.
An axis between the long non-coding RNA HOXA11-AS and NQOs enhances metastatic ability in oral squamous cell carcinoma.
Int J Mol Sci. 2022;23(18):10704. DOI:10.3390/ijms231810704 - Takayuki Fujii, Haruyuki Nakayama-Imaohji, Aya Tanaka, Hiroto Katami, Kazuya Tanaka, Yoichi Chiba, Machi Kawauchi, Masaki Ueno, Tomomi Kuwahara, Ryuichi Shimono.
Partially hydrolyzed guar gum alleviates hepatic steatosis and alters specific gut microbiota in a murine liver injury model.
Pediatric surgery international 2022;38(12):1759-1768. DOI:10.1007/s00383-022-05221-z - Naoko Yoshizawa-Sugata, Hisao Masai.
Histone Modification Analysis of Low-Mappability Regions.
Methods Mol Biol. 2022;2519:163-185. DOI:10.1007/978-1-0716-2433-3_18 - Taniguchi M, Iwahashi M, Oka Y. Tiong YXS, Sato M.
Fezf2-positive fork cell-like neurons in the mouse insular cortex.
PLoS One 2022;17(9):e0274170. DOI:10.1371/journal.pone.0274170 - Keita Mitani, Masanori Kawabata, Yoshikazu Isomura, Yutaka Sakai.
Automated and parallelized spike collision tests to identify spike signal projections.
iScience 2022;25(10):105071. DOI:10.1016/j.isci.2022.105071 - Zhao T, Chida A, Shichino Y, Choi D, Mizunuma M, Iwasaki S, and Ohya Y.
Multifarious translational regulation during replicative aging in yeast.
J. Fungi 2022;8(9):938. DOI:10.3390/jof8090938 - Nobuyuki Sakayori, Masanori Katakura, Susumu Setogawa, Makoto Sugita, Kazuto Kobayashi.
Characterization of the fatty acid profile in the ventral midbrain of mice exposed to dietary imbalance between omega-6 and omega-3 fatty acids during specific life stages.
BMC Research Notes 2022;15:285. DOI:10.1186/s13104-022-06175-0 - Iwasaki S, Kaneda K.
Genes relating to biological processes of endometriosis: expression changes common to a mouse model and patients.
Drug Research 2022;72(9):523-533. DOI:10.1055/a-1894-6817 - Sato T, Oda K, Sakai S, Kato R, Yamamori S, Itakura M, Kodera Y, Nishizawa M, Sasaoka T, Onodera O, Yokoyama M.
Importance of the Q/N-rich segment for protein stability and activity of endogenous mouse TDP-43.
Scientific Reports 2022;12:14923. DOI:10.1038/s41598-022-19153-0 - Yoshida Y, Shimizu I, Oda K, Sasaoka T, Abe M, Sakimura K, Kubota Y, Yoshimura N, Kajimura S, Zuriaga M, Walsh K, Soga T, Minamino T et al.
Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism.
Scientific Reports 2022;12:14883. DOI:10.1038/s41598-022-19245-x - Mizuki Yamamoto, Jun-Ichiro Inoue, et al.
Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein.
mBio 2022;13(4):e0051922. DOI:10.1128/mbio.00519-22 - Nagai M, Iemura K, Kikkawa T, Naher S, Hattori S, Hagihara H,Nagata KI,Anzawa H,Kugisaki R,Wanibuchi H,Abe T,Inoue K, Kinoshita K, Miyakawa T, Osumi N, Tanaka K.
Deficiency of CHAMP1, a gene related to intellectual disability, causes impaired neuronal development and a mild behavioural phenotype.
Brain Communications 2022;4(5):fcac220. DOI:10.1093/braincomms/fcac220 - Zhang T, Nishitani N, Niitani K, Nishida R, Futami Y, Deyama S, Kaneda K.
A spatiotemporal increase of neuronal activity accompanies the motivational effect of wheel running in mice.
Behavioural Brain Research 2022;432:113981. DOI:10.1016/j.bbr.2022.113981 - Tsujimoto G, Ito R, Yoshikawa K, Ueki C, Okada N.
NFYA promotes the anti-tumor effects of gluconeogenesis in hepatocellular carcinoma through the regulation of PCK1 expression.
Frontiers in Cell and Developmental Biology 2022;10:983599. DOI:10.3389/fcell.2022.983599 - Kobayashi D, Watarai T, Ozawa M, Kanda Y, Saika F, Kiguchi N, Takeuchi A, Ikawa M, Matsuzaki S, Katakai T.
Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway.
Frontiers in Immunology 2022;13:973880. DOI:10.3389/fimmu.2022.973880 - Tokutake T, Asano T, Miyanishi H, Nakaya S, Izuo N, Nitta A.
Cannabinoid type 1 receptors in the basolateral amygdala regulate ACPA‐induced place preference and anxiolytic‐like behaviors.
Neurochem Res. 2022;47(9):2899-2864. DOI:10.1007/s11064-022-03708-8 - Barra L, Awakawa T, Abe I.
Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis.
JACS Au. 2022;,2(9):1950-1963. DOI:10.1021/jacsau.2c00391 - Mizutani H, Sato Y, Yamazaki M, Yoshizawa T, Ando Y, Ueda M, Yamagata K.
SIRT7 deficiency protects against Aβ42-induced apoptosis through the regulation of NOX4-derived reactive oxygen species production in SH-SY5Y cells.
Int. J. Mol. Sci. 2022;23(16):9027. DOI:10.3390/ijms23169027 - Yoshioka, Y., Shimomura, M., Saito, K., Ishii, H., Doki, Y., Eguchi, H., Nakatsura, T., Ito, T., Kuroda, M., Mori, M., Ochiya, T.
Circulating cancer-associated extracellular vesicles as early detection and recurrence biomarkers for pancreatic cancer.
Cancer Science 2022;113(10):3498-3509. DOI:10.1111/cas.15500 - Ishikawa K, Sugimoto S, Oda M, Fujii M, Toshimitsu K, Sawada K, Shimokawa M, Saito M, Kawasaki K, Ishii R, Taniguchi K, Sato T.
Identification of Quiescent LGR5+ Stem Cells in the Human Colon.
Gastroenterology 2022;163(5):1391-1406.e24. DOI:10.1053/j.gastro.2022.07.081 - Sachiko Fujiwara,Thanh Phuong Nguyen,Kyoko Furuse,Yugo Fukazawa,Tetsuhisa Otani,Mikio Furuse.
Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif.
Annals of the New York Academy of Sciences 2022;1516:85-94. DOI:10.1111/nyas.14881 - Kikuchi Y, Sugano E, Honma Y, Perez E, Stock M, Fernandez J R, Tamura M, Voronkov M, Stock J B, Tomita H.
SIG-1451, a Novel, Non-Steroidal Anti-Inflammatory Compound, Attenuates Light-Induced Photoreceptor Degeneration by Affecting the Inflammatory Process.
International Journal of Molecular Sciences 2022;23(15):8802. DOI:10.3390/ijms23158802 - Oikawa D, Gi M, Kosako H, Shimizu K, Takahashi H, Shiota M, Hosomi S, Komakura K, Wanibuchi H, Tsuruta D, Sawasaki T, Tokunaga F.
OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways.
Cell Death Dis. 2022;13(8):694. DOI:10.1038/s41419-022-05145-5 - Zhang Q, Terawaki S, Oikawa D, Okina Y, Usuki Y, Ito H, Tokunaga F.
Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43.
Cells 2022;11(15):2398. DOI:10.3390/cells11152398 - Shichino Y and Iwasaki S.
Compounds for selective translational inhibition.
Curr Opin Chem Biol. 2022;69,:02158. DOI:10.1016/j.cbpa.2022.102158 - Yamaguchi Y, Murai I, Takeda M, Doi S, Seta T, Hanada R, Kangawa K, Okamura H, Miyake T, Doi M.
Nmu/Nms/Gpr176 triple-deficient mice show enhanced light-resetting of circadian locomotor activity.
Biol. Pharm. Bull. 2022;45(8):1172-1179. DOI:10.1248/bpb.b22-00260 - Nakao, Y., Nakamura, S., Htun, Y., Mitsuie, T., Koyano, K., Ohta, K., Konishi, Y., Miki, T., Ueno, M., Kusaka, T.
Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets.
Sci Rep. 2022;12:3157. DOI:10.1038/s41598-022-16625-1 - Guo X, Tan S, Wang T, Sun R, Li S, Tian P, Li M, Wang Y, Zhang Y, Yan Y, Dong Z, Yan L, Yue X, Wu Z, Li C, Yamagata K, Gao L, Ma C, Li T, Liang X.
NAD+ salvage governs mitochondrial metabolism invigorating NK cell anti-immunity.
Hepatology 2022;78(2):468-485. DOI:10.1002/hep.32658 - 鈴木佐和子, 横手幸太郎
糖尿病 副腎疾患と糖尿病
糖尿病 2022;65(7):357-360. DOI:10.11213/tonyobyo.65.357 - Yuka Kusui, Naotaka Izuo, Kyosuke Uno, Bin Ge, Shin-Ichi Muramatsu, Atsumi Nitta.
Knockdown of Piccolo in the Nucleus Accumbens Suppresses Methamphetamine-Induced Hyperlocomotion and Conditioned Place Preference in Mice.
Neurochem Res. 2022;47:2856-2864. DOI:10.1007/s11064-022-03680-3 - Toyokuni S, Kong Y, Zheng H, Maeda Y, Motooka Y, Akatsuka S.
Iron as spirit of life to share under monopoly.
Journal of Clinical Biochemistry and Nutrition 2022;,71(2);78-88. DOI:10.3164/jcbn.22-43 - Hara Y, Ando F, Oikawa D, 10人略, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika H, Tokunaga F, Uchida S.
LRBA is essential for urinary concentration and body water homeostasis.
PNAS 2022;119(30):e2202125119. DOI:10.1073/pnas.2202125119 - Egawa J, Arta RK, Lemmon VP, Muñoz-Barrero M, Shi Y, Igarashi M, Someya T.
The cyclin G-associated kinase (GAK) inhibitor SCG-GAK-1 inhibits neurite outgrowth and synapse formation.
Mol Brain, 2022;15(1):68. DOI:10.1186/s13041-022-00951-6 - Masai, H.
TT-pocket/HIRAN: binding to 3’-terminus of DNA for recognition and processing of stalled replication forks.
J. Biochem. 2022;172(2):57-60. DOI:10.1093/jb/mvac042 - Suzuki, Y., Moritoki, K., Kajiwara, M., Yanagita, R. C., Kawanami, Y., Hanaki, Y., Irie, K.
Design, synthesis, and biological activity of a synthetically accessible analog of aplysiatoxin with an (R)-(−)-carvone-based conformation-controlling unit.
Bioscience, Biotechnology, and Biochemistry 2022;86(8):1013-1023. DOI:10.1093/bbb/zbac084 - Tao H, Abe I.
Harnessing Fe(II)/α-ketoglutarate-dependent oxygenases for structural diversification of fungal meroterpenoids.
Curr Opin Biotechnol. 2022;77:102763. DOI:10.1016/j.copbio.2022.102763 - Ono M, Komatsu M, Ji B, Takado Y, Shimojo M, Minamihisamatsu T, Warabi E, Yanagawa T, Matsumoto G, Aoki I, Kanaan NM, Suhara T, Sahara N, Higuchi M.
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy.
Aging Cell 2022;21(7):e13615. DOI:10.1111/acel.13615 - Sato D. X, Y. U. Inoue, .., M. Kawata.
Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety.
iScience 2022;25(8):104800. DOI:10.1016/j.isci.2022.104800 - Chhipi-Shrestha JK, Yoshida M, and Iwasaki S.
Filter trapping protocol to detect aggregated proteins in human cell lines.
STAR Protoc 2022;3(3):101571. DOI:10.1016/j.xpro.2022.101571 - Rina Fujiwara-Tani, Sasaki T, Takagi T, Mori S, Kishi S, Nishiguchi Y, Ohmori H, Fujii K, Kuniyasu H.
Gemcitabine resistance in pancreatic ductal carcinoma cell lines stems from reprogramming of energy metabolism.
Int J Mol Sci. 2022;23(14):7824. DOI:10.3390/ijms23147824 - Inubushi T, Nakanishi Y, Abe M, Takahata Y, Nishimura R, Kurosaka H, Irie F, Yamashiro T, Yamaguchi Y.
The cell surface hyaluronidase TMEM2 plays an essential role in mouse neural crest cell development and survival.
PLoS Genetics 2022;18(7):e1009765. DOI:10.1371/journal.pgen.1009765 - Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, .., Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F.
Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway.
J Clin Invest. 2022;132(17):e156501. DOI:10.1172/JCI156501 - Nakayama, M., Ozato, Y., Tsuji, Y., Arao, Y., Otsuka, C., Hamano, Y., Sumi, G., Ofusa, K., Uchida, S., Vecchione, A., Ishii, H.
RNA modification in inflammatory bowel diseases.
Biomedicines 2022;10(7):1695. DOI:10.3390/biomedicines10071695 - Yusuke Yoshigoe, Yohei Tanji, Yusei Hata, Kohtaro Osakada, Shinichi Saito, Eiichi Kayahara, Shigeru Yamago, Yoshitaka Tsuchido, and Hidetoshi Kawai.
Dynamic Au–C σ-Bonds Leading to an Efficient Synthesis of [n]Cycloparaphenylenes (n = 9–15) by Self-Assembly.
JACS Au 2022;2(8):1857-1868. DOI:10.1021/jacsau.2c00194 - Mori T, Nakashima Y, Morita H, Abe I.
Structure, function, and engineering of plant polyketide synthases.
Methods Enzymol. 2022;676:3-48. DOI:10.1016/bs.mie.2022.06.003 - Sawagashira, R. & Tanaka, M.
Nicotine promotes the utility of short-term memory during visual search in macaque monkeys.
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Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody.
J Immunother Cancer 2022;10(7):e004616. DOI:10.1136/jitc-2022-004616 - Saeki N., Itoh Y., Kanai R., Itoh S., Inubushi T., Akiyama S., Inui-Yamamoto C., Abe M.
Pregnane X receptor (PXR) represses osteoblast differentiation through repression of the Hedgehog signaling pathway.
Exp Cell Res. 2022;416(1):113156. DOI:10.1016/j.yexcr.2022.113156 - 吉田穂波
災害時に母子を支えるために—心理的安全性を築く拠点づくりの重要性—
地域保健 2022;7:28-34. - Tatekawa, S., Tamari, K., Chijimatsu, R., Konno, M., Motooka, D., Mitsufuji, S., Akita, H., Kobayashi, S., Murakumo, Y., Doki, Y., Eguchi, H., Ishii, H. et al.
N(6) methyladenosine methylation regulated polo like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma.
Scientific Reports 2022;12:11074. DOI:10.1038/s41598-022-15196-5 - Hashimoto K, Ide S, Arata M, Nakata A, Ito A, Ito TK, Kudo N, Lin B, Nunomura K, Tsuganezawa K, Yoshida M, Nagaoka Y, Sumiyoshi T.
Discovery of Benzylpiperazine Derivatives as CNS-Penetrant and Selective Histone Deacetylase 6 Inhibitors.
ACS Med. Chem. Lett. 2022;13(7):1077-1082. DOI:10.1021/acsmedchemlett.2c00081 - Kakeru Chino, Naotaka Izuo, Hiroshi Noike, Kyosuke Uno, Tomoharu Kuboyama, Chihiro Tohda, Shin-Ichi Muramatsu, Atsumi Nitta.
Shati/Nat8l Overexpression Improves Cognitive Decline by Upregulating Neuronal Trophic Factor in Alzheimer's Disease Model Mice.
Neurochem Res. 2022;47:2805-2814. DOI:10.1007/s11064-022-03649-2 - Chijimatsu, R., Takeda, Y., Tatekawa, S., Sasaki, K., Motooka, D., Ohshiro, T., Taniguchi, M., Ogawa, K., Mori, M., Doki, Y., Eguchi, H., Ishii, H. et al.
Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinoma.
iScience 2022;25:104659. DOI:10.1016/j.isci.2022.104659 - Naoaki Kurisawa, Arihiro Iwasaki, Kazuya Teranuma, Shingo Dan, Chikashi Toyoshima, Masaru Hashimoto, and Kiyotake Suenaga.
Structural Determination, Total Synthesis, and Biological Activity of Iezoside, a Highly Potent Ca2+ -ATPase Inhibitor from the Marine Cyanobacterium Leptochromothrix valpauliae.
J. Am. Chem. Soc. 2022;144(24):11019-11032. DOI:10.1021/jacs.2c04459 - Mori T, Abe I.
Structural basis for endoperoxide-forming oxygenases.
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A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice.
NAR Cancer 2022;4(2):zcac019. DOI:10.1093/narcan/zcac019 - Youichi Tajima, Futoshi Shibasaki, Hisao Masai.
Cell fusion upregulates PD-L1 expression and promotes tumor formation.
bioRxiv 2022;496068. DOI:10.1101/2022.06.14.496068 - Tani N, Tanno N, Ishiguro K.
Tandem immuno-purification of affinity-tagged proteins from mouse testis extracts for MS analysis.
STAR Protocols 2022;3(2):10145. DOI:10.1016/j.xpro.2022.101452 - Toshio Fujino, Kenichi Suda, Takamasa Koga, Akira Hamada, Shuta Ohara, Masato Chiba, Masaki Shimoji, Toshiki Takemoto, Junichi Soh, Tetsuya Mitsudomi.
Foretinib can overcome common on-target resistance mutations after capmatinib/tepotinib treatment in NSCLCs with MET exon 14 skipping mutation.
Journal of Hematology & Oncology 2022;15:79. DOI:10.1186/s13045-022-01299-z - Maesaka F, Kuwada M, Horii S, Kishi S, Fujiwara-Tani R, Mori S, .., Bhawal UK, Luo Y, Kondoh M, Fujimoto K, Kuniyasu H.
Hypomethylation of CLDN4 gene promoter is associated with malignant phenotype in urinary bladder cancer.
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METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance.
eLife 2022;11:e72780. DOI:10.7554/eLife.72780 - Sakamoto M, Ota K, Kondo Y, Okamura M, Fujii H, Bito H.
In utero electroporation and cranial window implantation for in vivo wide-field two-photon calcium imaging using G-CaMP9a transgenic mice.
Star Protocols 2022;3(2):101421. DOI:10.1016/j.xpro.2022.101421 - Suzuki S, Ruike Y, Ishiwata K, Naito K, Igarashi K, Ishida A, Fujimoto M, Koide H, Horiguchi K, Tatsuno I, Yokote K.
Clinical Usefulness of the Growth Hormone-Releasing Peptide-2 Test for Hypothalamic-Pituitary Disorder.
J Endocr Soc. 2022;6(8):bvac088. DOI:10.1210/jendso/bvac088 - Nakai S, Tateoka Y, Miyaguchi Y, Takahashi M, Ogita H.
Associations Between Habitual Dietary Behaviors and Glutamic Acid Levels in Human Milk
J Hum Lact. 2022;39(2):315-324. DOI:10.1177/08903344221095784 - Yun-Wei Xue, Hiroaki Itoh, Shingo Dan, Masayuki Inoue.
Gramicidin A Accumulates in Mitochondria, Reduces ATP Levels, Induces Mitophagy, and Inhibits Cancer Cell Growth.
Chemical Science 2022;13(25):7482-7491. DOI:10.1039/D2SC02024F - Yamada A, Toya H, Tanahashi M, Kurihara M, Mito M, Iwasaki S, Kurosaka S, Takumi T, Fox A, Kawamura Y, Miura K, and Nakagawa S.
Species-specific formation of paraspeckles in intestinal epithelium revealed by characterization of NEAT1 in naked mole-rat.
RNA 2022;28(8):1128-1143. DOI:10.1261/rna.079135.122 - Kazuhiro Sakamoto, Hinata Yamada, Norihiko Kawaguchi, Yoshito Furusawa, Naohiro Saito, Hajime Mushiake.
Reinforcement Learning Model With Dynamic State Space Tested on Target Search Tasks for Monkeys: Extension to Learning Task Events.
Frontiers in Computational Neuroscience 2022;16:84604. DOI:10.3389/fncom.2022.784604 - Tao H, Mori T, Adachi N, Kawasaki M, Moriya T, Senda T, Abe I, Dickschat JS, Liu T.
Discovery of non-squalene triterpenes.
Nature 2022;606(7913):414-419,10. DOI:1038/s41586-022-04773-3 - Hieu VN, Thuy LTT, Hai H, Dat NQ, Hoang DV, Hanh NV, Phuong DM, Hoang TH, Sawai H, Shiro Y, Sato-Matsubara M, Oikawa D, Tokunaga F, Yoshizato K, Kawada N.
Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion.
Redox Biol 2022;52:102286. DOI:10.1016/j.redox.2022.102286 - Arao, Y., Nakayama, M., Tsuji, Y., Hamano, Y., Otsuka, C., Vecchione, A., Ofusa, K., Ishii, H.
EpisomiR, a new family of miRNAs, and its possible roles in human.
Biomedicines 2022;10(6):1280. DOI:10.3390/biomedicines10061280 - Iori Ohmori, Mamoru Ouchida, Masakazu Shinohara, Kiyoka Kobayashi, Saeko Ishida, Tomoji Mashimo.
Novel animal model of combined generalized and focal epilepsy.
Epilepsia 2022;63(7) :e80-e85. DOI:10.1111/epi.17295 - Kong Y, Akatsuka S, Motooka Y, Zheng H, Cheng Z, Shiraki Y, Mashimo T, Imaoka T, Toyokuni S.
BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance.
Redox Biology 2022;54,102356. DOI:10.1016/j.redox.2022.102356 - Morimoto y, Tokumitsu A, .., Shigeki Ohta.
TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF).
Neurochem Res. 2022;47:741–2756. DOI:10.1007/s11064-022-03629-6 - Oota-Ishigaki A, Takao K, Yamada D, Sekiguchi M, Itoh M, Koshidata Y, Abe M, Natsume R, .., Sakimura K, Okuno H, Wada K, Mishima M, Miyakawa T, Hayashi T.
Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice.
Neuropsychopharmacology 2022;47:2150-2159. DOI:10.1038/s41386-022-01347-9 - Okada N, Ueki C, Shimazaki M, Tsujimoto G, Kohno S, Muranaka H, Yoshikawa K, Takahashi C.
NFYA promotes the malignant behavior of triple-negative breast cancer through the regulation of lipid metabolism.
bioRxiv 2022;493660. DOI:10.1101/2022.05.26.493660 - Ding WX, Ni HM, Waguri S, Komatsu M.
Lack of Hepatic Autophagy Promotes Severity of Liver Injury but Not Steatosis.
J Hepatol. 2022;77(5):1458-1459. DOI:10.1016/j.jhep.2022.05.015 - N Kondo, Y Sakurai, T Takata, K Kano, K Kume, M Maeda, N Takai, S Suzuki et al.
Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation.
scientific reports 2022;12:8718. DOI:10.1038/s41598-022-12293-3 - Asano T, Nakamura H,..Takano H, Yao R,.. Doi H, Tanaka F.
Inhibition of Crmp1 phosphorylation at Ser522 ameliorates motor function and neuronal pathology in amyotrophic lateral sclerosis model mice.
eNeuro 2022;9(3):ENEURO.0133-22. DOI:10.1523/ENEURO.0133-22.2022 - Suzuki A, Iwaya C, Ogata K, Yoshioka H, Shim J, Tanida I, Komatsu M, Tada N, Iwata J.
Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren's syndrome-like exocrinopathy.
Cell Mol Life Sci. 2022;79:307. DOI:10.1007/s00018-022-04334-x - Kishi S, Fujiwara-Tani R, Honoki H, Sasaki R, Mori S, Ohmori H, Sasaki T, Miyagawa Y, Kawahara I, Kido A, Tanaka Y, Kuniyasu H.
Oxidized high mobility group B-1 on colorectal cancer via metastasis modification of mesenchymal stem cells.
Cancer Sci. 2022;113(8):2904-2915. DOI:10.1111/cas.15400 - Lyu J, Ushimaru R, Abe I.
Characterization of Enzymes Catalyzing the Initial Steps of the β-Lactam Tabtoxin Biosynthesis
Org Lett. 2022;24(18):3337-3341. DOI:10.1021/acs.orglett.2c00878 - Kazuhiro Sakamoto, Norihiko Kawaguchi, Hajime Mushiake.
Shape and Rule Information Is Reflected in Different Local Field Potential Frequencies and Different Areas of the Primate Lateral Prefrontal Cortex.
Frontiers in Behavioral Neuroscience 2022;16:750832. DOI:10.3389/fnbeh.2022.750832 - Fang Q, Kimura Y, Shimazu T, Suzuki T, Dohmae N, Iwasaki S, and Shinkai Y.
Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors.
Sci Rep. 2022;12:4104. DOI:10.1038/s41598-022-08061-y - Zhang L, Awakawa T, Abe I.
Understanding and Manipulating Assembly Line Biosynthesis by Heterologous Expression in Streptomyces.
Methods Mol Biol. 2022;2489:223-238. DOI:10.1007/978-1-0716-2273-5_12 - Toshiaki Wayama, Yuta Arai, Hiroki Oguri.
Regiocontrolled Dimerization of Densely Functionalized 1,6-Dihydropyridines for the Biomimetic Synthesis of a Halicyclamine-type Scaffold by Preventing Disproportionation.
J. Org. Chem. 2022;87(9):5938-5951. DOI:10.1021/acs.joc.2c00212 - Okada, K-I., Takeya, R. & Tanaka, M.
Neural signals regulating motor synchronization in the primate deep cerebellar nuclei.
Nat Commun 2022;13:2504. DOI:10.1038/s41467-022-30246-2 - Kawasaki, Y.; Rashid, S.; Ikeyatsu, K.; Mutoh, Y.; Yoshigoe, Y.; Kikkawa, S.; Azumaya, I.; Hosoya, S.; Saito, S.
Conformational Control of [2]Rotaxane by Hydrogen Bond.
JOURNAL OF ORGANIC CHEMISTRY 2022;87(9):5744-5759. DOI:10.1021/acs.joc.2c00086 - Mori T, Nakashima Y, Chen H, Hoshino S, Mitsuhashi T, Abe I.
Structure-based redesign of Fe(II)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation.
Chem Commun. 2022;58(36):5510-5513. DOI:10.1039/d2cc00736c - Hoang DV, Thuy LTT, Hai H, Hieu VN, Kimura K, Oikawa D, .., Tokunaga F, Kubo S, Ohtani N, Yoshizato K, Kawada N.
Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species.
Oncogenesis 2022;11:23. DOI:10.1038/s41389-022-00389-4 - Shunske Tomita, Kazuho Inaba, Masashi Sekimoto.
Tyrphostin AG1024 downregulates aryl hydrocarbon receptor (AhR) expression in an IGF1R and IR-independent manner.
Toxicology Letters 2022;360:62-70. DOI:10.1016/j.toxlet.2022.02.003 - 竹馬俊介
免疫系における内在性レトロウイルスの役割
臨床免疫・アレルギー科 2022;77(5):645-650 - Naoya Aoki, Chihiro Mori, Toshiyuki Fujita, Shouta Serizawa, Shinji Yamaguchi, Toshiya Matsushima, Koichi J Homma.
Subtype-selective contribution of muscarinic acetylcholine receptors for filial imprinting in newly-hatched domestic chicks.
Behavioural brain research 2022;424:113789. DOI:10.1016/j.bbr.2022.113789 - Tokunaga F, Ikeda F.
Linear ubiquitination in immune and neurodegenerative diseases, and beyond.
Biochem Soc Trans. 2022;50(2):799-811. DOI:10.1042/BST20211078 - Sato M, Sato-Yamamoto N, Wakita A, Haraguchi M, Shimonishi M, Okuno H.
Direct injection of recombinant AAV-containing solution into the oviductal lumen of pregnant mice caused in situ infection of both preimplantation embryos and oviductal epithelium.
Int J Mol Sci. 2022;23(9):4897. DOI:10.3390/ijms23094897 - Ohshiro, T., Asai, A., Konno, M., Ohkawa, M., Komoto, Y., Ofusa, K., Ishii, H., Taniguchi, M.
Direct observation of DNA alterations induced by a DNA disruptor.
Science Reports 2022;12:6945. DOI:10.1038/s41598-022-10725-8 - Hanna M Ciesielski, Hiroshi Nishida, Tomomi Takano, Aya Fukuhara, Tetsuhisa Otani, Yuko Ikegawa, Morihiro Okada, Takashi Nishimura, Mikio Furuse, Sa Kan Yoo.
Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes.
PLoS biology 2022;20(4):e3001586. DOI:10.1371/journal.pbio.3001586 - Oikawa T, Fukuda T, Yamashita T, Tomita H, Ozaki T.
Lentiviral expression of calpain-1 C2-like domain peptide prevents glutamate-induced cell death in mouse hippocampal neuronal HT22 cells.
In Vitro Cellular & Developmental Biology - Animal 2022;58:289-294. DOI:10.1007/s11626-022-00683-w - Yuriko Saheki, Naoya Aoki, Koichi J Homma, Toshiya Matsushima.
Suppressive Modulation of the Chick Forebrain Network for Imprinting by Thyroid Hormone: An in Vitro Study.
Frontiers in physiology 2022;13:881947. DOI:10.3389/fphys.2022.881947 - Mai Izumida, Osamu Kotani, Hideki Hayashi, Chris Smith, Tsutomu Fukuda, Koushirou Suga, Masatomo Iwao, Fumito Ishibashi, Hironori Sato, and Yoshinao Kubo.
Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2.
Viruses 2022;14(4):816. DOI:10.3390/v14040816 - Miyanishi H, Kitazawa A, Izuo N, Muramatsu SI, Nitta A.
N‐acetyl transferase, Shati/Nat8l, in the dorsal hippocampus suppresses aging‐induced impairment of cognitive function in mice.
Neurochem Res. 2022;47(9):2703-2714. DOI:10.1007/s11064-022-03594-0 - Showkat Rashid, Yusuke Yoshigoe, Shinichi Saito.
Phenanthroline based rotaxanes: recent developments in syntheses and applications.
RSC Advances 2022;12(18):11318-11344. DOI:10.1039/D2RA01318E - Hiroshi Gomi, Takahiro Nagumo, Kazushi Asano, Makoto Konosu, Tadashi Yasui, Seiji Torii, Masahiro Hosaka.
Differential expression of secretogranin II and III in canine adrenal chromaffin cells and pheochromocytomas.
Journal of Histochemistry & Cytochemistry 2022;70(5):335-356. DOI:10.1369/00221554221091000 - Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J Homma, Shinji Yamaguchi.
Chick Hippocampal Formation Displays Subdivision- and Layer-Selective Expression Patterns of Serotonin Receptor Subfamily Genes.
Frontiers in physiology 2022;13:882633. DOI:10.3389/fphys.2022.882633 - Danjo Y, Shigetomi E, Hirayama YJ, Kobayashi K, Ishikawa T, Fukazawa Y, Shibata K, Takanashi K, Parajuli B, Shinozaki Y, Kim SK, Nabekura J and *Koizumi S.
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice.
J Exp Med. 2022;219(4):e20210989. DOI:10.1084/jem.20210989 - Hojo Y, Kishi S, Mori S, Fujiwara-Tani R, Sasaki T, Fujii K, Nakashima C, Luo Y, Shinohara H, Kuniyasu H.
Sunitinib and pterostilbene combination treatment exerts anti-tumor effects in gastric cancer via suppression of PDZD8.
Int J Mol Sci. 2022;23(7):4002. DOI:10.3390/ijms23074002 - 小山内 実
マルチスケールカルシウムイメージング技術
日本材料科学会誌 材料の科学と工学 2022;59:38-41. - Owari T, Tanaka N, Nakai Y, Miyake M, Anai S, Kishi S, Mori S, Tani-Fujiwara R, .., Hasegawa M, Fujimoto K, Kuniyasu H.
5-Aminolevulinic acid sensitizes prostate cancer cells to radiation therapy and overcomes hypoxia-induced radiation resistance by enhancing mitochondrial reactive oxygen species production.
Br J Cancer 2022;127(2):350-363. DOI:10.1038/s41416-022-01789-4 - Keita Anoyama, Gen Onodera, Tsutomu Fukuda, Masanari Kimura.
C−H Silylation of 2-Arylpyridine Derivatives by Using Iridium Catalyst and Phosphine-Borane Ligand.
Advanced Synthesis & Catalysis 2022;364(7):1223-1227. DOI:10.1002/adsc.202101476 - Niu J, Holland SM, Ketschek A, Collura KM, Hesketh NL, Hayashi T, Gallo G, Thomas G.
Palmitoylation couples the kinases DLK and JNK3 to facilitate prodegenerative axon-to-soma signaling.
Science Signaling 2022;15:eabh2674. DOI:10.1126/scisignal.abh2674 - Okada M, Kawagoe Y, Takasugi T, Nozumi M, Ito Y, Fukusumi H, Kanemura Y, Fujii Y, Igarashi M.
JNK1-dependent phosphorylation of GAP-43 Serine 142 is a novel molecular marker for axonal growth.
Neurochem Res. 2022;47:2668-2682. DOI:10.1007/s11064-022-03580-6 - Kaori Oka, Shusuke Fujioka, Yoshimi Kawamura, Kimi Araki, Kyoko Miura, et al.
Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats.
Communications biology 2022;5:287. DOI:10.1038/s42003-022-03241-y - Kasahara Y, Masukawa D, Kobayashi K, Yamasaki M, Watanabe M, Goshima Y.
L-DOPA-Induced Neurogenesis in the Hippocampus Is Mediated Through GPR143, a Distinct Mechanism of Dopamine.
Stem Cells 2022;40(2):215-226. DOI:10.1093/stmcls/sxab013 - Ofusa, K., Chijimatsu, R., Ishii, H.
Detection techniques for epitranscriptomic marks.
American Journal of physiology 2022;322(4):C787-C793. DOI:10.1152/ajpcell.00460.2021 - Haruka Sato, Jun Hatakeyama, Takuji Iwasato, Kimi Araki, Nobuhiko Yamamoto, Kenji Shimamura.
Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF.
eLife 2022;11:e67549. DOI:10.7554/eLife.67549 - Naoya Aoki, Chihiro Mori, Toshiyuki Fujita, Shouta Serizawa, Shinji Yamaguchi, Toshiya Matsushima, Koichi J Homma.
Imprintability of Newly Hatched Domestic Chicks on an Artificial Object: A Novel High Time-Resolution Apparatus Based on a Running Disc.
Frontiers in physiology 2022;13:822638. DOI:10.3389/fphys.2022.822638 - Kimura Y, Saito H, Osaki T, Ikegami Y, Wakigawa T, Ikeuchi Y, and Iwasaki S.
Mito-FUNCAT-FACS reveals cellular heterogeneity in mitochondrial translation.
RNA 2022;28(6):895-904. DOI:10.1261/rna.079097.122 - Ryo Tanifuji, Naoto Haraguchi, Hiroki Oguri.
Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC.
Tetrahedron Chem. 2022;1:100010. DOI:10.1016/j.tchem.2022.100010 - Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yurika Tokunaga, Yoshinori Hasegawa, Kimi Araki, Yuichi Wakabayashi.
Functional polymorphism in Pak1-3'UTR alters skin tumor susceptibility by alternative polyadenylation.
Journal of Investigative Dermatology 2022;142(9):2323-2333.e12. DOI:10.1016/j.jid.2022.02.009 - Chihiro Mori, Naoya Aoki, Toshiyuki Fujita, Shinji Yamaguchi, Toshiya Matsushima, Koichi J Homma.
Gene expression profiles of the muscarinic acetylcholine receptors in brain regions relating to filial imprinting of newly-hatched domestic chicks.
Behavioural brain research 2022;420:113708. DOI:10.1016/j.bbr.2021.113708 - Wang C, Horigane SI, Wakamori M, Aleksic B, Takemoto-Kimura S et al.
Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder.
Transl Psychiatry 2022;12(1):84. DOI:10.1038/s41398-022-01851-y - Takeda,Y., Chijimatsu,R., Ofusa, K., Kobayashi,Y., Doki,Y., Eguchi,.H., Ishii, H.
Cancer metabolism challenges genomic instability and clonal evolution as therapeutic targets.
Canser Science 2022;113(4):1097-1104. DOI: - 岩崎信太郎
ダイソームプロファイリング法によるリボソーム衝突の網羅探索
Journal of Japanese Biochemical Society 2022;94(1):87-91. DOI:10.14952/SEIKAGAKU.2022.940087 - Sakai M, Yu Z, Hirayama R, Nakasato M, Kikuchi Y, Ono C, Komatsu H, Nakanishi M, Yoshii H, Stellwagen D, Furuyashiki T, Komatsu M, Tomita H.
Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance.
Neural Plast. 2022;,7503553. DOI:10.1155/2022/7503553 - Hikita T, Uehara R, Itoh RE, Mitani F, Miyata M, Yoshida T, Yamaguchi R, Oneyama C.
MEK/ERK-mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function.
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Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction.
Nature Aging 2022;2:105-114. DOI:10.1038/s43587-021-00167-8 - Tokio Katakura, Mikihiro Yoshida, Haruki Hisano, Hajime Mushiake, Kazuhiro Sakamoto.
Reinforcement Learning Model with Dynamic State Space Tested on Target Search Tasks for Monkeys: Self-Determination of Previous States Based on Experience Saturation and Decision Uniqueness.
Frontiers In Computational Neuroscience 2022;15:784592. DOI:10.3389/fncom.2021.784592 - Nakano M, Koga M, Hashimoto T, Matsushita N, Masukawa D, Mizuno Y, Uchimura H, Niikura R, Miyazaki T, Nakamura F, Goshima Y.
Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.
J Pharmacol Sci. 2022;148(2):214-220. DOI:10.1016/j.jphs.2021.11.008 - Kondo Y, Honoki K, Kishi S, Mori S, Tsukamoto S, Fujii H, Kuniyasu H, Tanaka Y.
Endosialin/CD248 may be a potential therapeutic target to prevent the invasion and metastasis in osteosarcoma.
Oncol Lett. 2022;23(2):42. DOI:10.3892/ol.2021.13160 - Aizawa H, Kato H, Oba K, Kawahara T, Okubo Y, Sito T, Naito M, .., Kwak S.
Randamized lphase 2 study of perampanel for sporadic amyotrophic lateral sclerosis.
J Neurology 2022;269(2):885-896. DOI:10.1007/s00415-021-10670-y - 竹馬俊介
TRIM28は内在性レトロウイルスの抑制を通じ、T細胞免疫の暴走を抑制する
医学のあゆみ 2022;260(9):947-948 - Edamitsu T, Taguchi K, Okuyama R, Yamamoto M.
AHR and NRF2 in skin homeostasis and atopic dermatitis.
Antioxidants 2022;11(2):227. DOI:10.3390/antiox11020227 - Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J Homma, Shinji Yamaguchi.
Serotonergic Neurons in the Chick Brainstem Express Various Serotonin Receptor Subfamily Genes.
Frontiers in physiology 2022;12:815997. DOI:10.3389/fphys.2021.815997 - Ogata T, Shiori Mori S, Ohmori H, Kishi S, Fujiwara-Tani R, Sasaki T, Nishiguchi Y, Nakashima C, Goto K, Kawahara I, Yi Luo Y, Kuniyasu H.
Suppressive GLI2 fragment enhances liver metastasis in colorectal cancer.
Oncotarget 2022;13:122-135. DOI:10.18632/oncotarget.28170 - Morioka S, Nakanishi H, Yamamoto T, Hasegawa J, Tokuda E, Hikita T, Sakihara T, Kugii Y, Oneyama C, Yamazaki M, Suzuki A, Sasaki J, Sasaki T.
A mass spectrometric method for in-depth profiling phosphoinositide regioisomers and their disease-associated regulation.
Nature Commun. 2022;13:83. DOI:10.1038/s41467-021-27648-z - Kazuma Murakami, Naotaka Izuo, and Gal Bitan.
Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases.
J. Biol. Chem. 2022;298:101478. DOI:10.1016/j.jbc.2021.101478.
2021年度
- Sakamoto M, Inoue M, Takeuchi A, Kobari S, Yokoyama T, Horigane S, Takemoto-Kimura S, Abe M, Sakimura K, Kano M, Kitamura K, Fujii H, Bito H.
A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo.
Cell Reports Methods 2022;2:100168. DOI:10.1016/j.crmeth.2022.100168 - Shinji Kishimoto, Yuya Matsubara, Kenji Watanabe
Alkaloid biosynthetic enzyme generates diastereomeric pair via two distinct mechanisms.
Journal of the American Chemical Society 2022;144:5485-5493. DOI:10.1021/jacs.1c13621 - Akihito Yokosuka, Tatsuya Shimomura, Shohei Yokogawa, Airi Oguro, Katsunori Miyake, Yoshihiro Mimaki
Chemical components from Hedera rhombea leaves and their cytotoxicity.
Chemical and Pharmaceutical Bulletin 2022;70:175-181. DOI:10.1248/cpb.c21-00907 - Nae Saito, Makoto Itakura, Toshikuni Sasaoka
D1 Receptor Mediated Dopaminergic Neurotransmission Facilitates Remote Memory of Contextual Fear Conditioning.
Frontiers in Behavioral Neuroscience 2022;16:751053. DOI:10.3389/fnbeh.2022.751053 - Saegusa J, Osada Y, Miura K, Sasazawa Y, Ogura A, Takao KI, Simizu S.
Elucidation of structure-activity relationship of humulanolides and identification of humulanolide analog as a novel HSP90 inhibitor.
Bioorg Med Chem Lett 2022;60:128589. DOI:10.1016/j.bmcl.2022.128589 - Miura K, Kobayashi T, Zhang Z, Prasoon P, Hirose Y, Ishikawa H, Takizawa K, Sakata J, Miura S, Sasaoka T, Wakai T
Establishment of a long-term survival swine model for observation of transplanted islets: A preliminary step in an allogeneic transplant experiment.
Transplantation Proceedings 2022;54(2):507-512. DOI:10.1016/j.transproceed.2021.10.029 - Koji Kuraoka, Kae Nakamura
Facial temperature and pupil size as indicators of internal state in primates.
Neuroscience research 2022;175:25-37. DOI:10.1016/j.neures.2022.01.002 - Tanno N, Takemoto K, Takada-Horisawa Y, Shimada R., Fujimura S, Tani N., Takeda N., Araki K, Ishiguro K
FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis.
iScience 2022:in press. DOI:10.1016/j.isci.2022.104008 - Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yurika Tokunaga, Yoshinori Hasegawa, Kimi Araki, Yuichi Wakabayashi
Functional polymorphism in Pak1-3'UTR alters skin tumor susceptibility by alternative polyadenylation.
Journal of Investigative Dermatology 2022:in press. - Yun-Wei Xue, Hiroaki Itoh, Shingo Dan, Masayuki Inoue
Gramicidin A Accumulates in Mitochondria, Reduces ATP Levels, Induces Mitophagy, and Inhibits Cancer Cell Growth.
Chemical Science 2022:in press. DOI:10.1039/D2SC02024F - Wang, X.-H., Abe, I., Morita, H., Tu, P.-F., Shi, S.-P. et al.
Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood.
Nature Commun. 2022;13:348. DOI:10.1038/s41467-022-27971-z - Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.
Identification of a small molecule that enhances ferroptosis via inhibition of ferroptosis suppressor protein 1 (FSP1).
ACS Chem Biol 2022;17:483-491. DOI:10.1021/acschembio.2c00028 - Apostolopoulos A and Iwasaki S
Into the matrix: current methods for mitochondrial translation studies.
J Biochem. 2022;171:379-387. DOI:10.1093/jb/mvac005 - Sasaki L*, Hamada Y*, Yarimizu D*, (20 people), Miyake T, Doi M#
*:co-first, #:corresponding
Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction.
Nature Aging 2022;2:105-114. DOI:10.1038/s43587-021-00167-8 - Kohda, Y., Sakamoto, S., Umekita, M., Kimura, T., Kubota, Y., Arisaka, R., Shibuya, Y., Muramatsu, H., Sawa, R., Dan, S., Kawada, M., Igarashi, M.
Isolation of new derivatives of the 20-membered macrodiolide bispolide from Kitasatospora sp. MG372-hF19.
The Journal of Antibiotics 2022;75:77-85. DOI:10.1038/s41429-021-00492-5 - Sonja Thölmann, Jochen Seebach, Tetsuhisa Otani, Luise Florin, Hans Schnittler, Volker Gerke, Mikio Furuse, Klaus Ebnet
JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells.
Cellular and Molecular Life Sciences 2022;79:1-19. DOI:10.1007/s00018-022-04140-5 - Okada M, Kawagoe Y, Takasugi T, Nozumi M, Ito Y, Fukusumi H, Kanemura Y, Fujii Y, Igarashi M
JNK1-dependent phosphorylation of GAP-43 Serine 142 is a novel molecular marker for axonal growth.
Neurochem Res 2022:in press. - Riki Furuhata, R., Imasaka, M., Sugimoto, M., Yoshinobu, K., Araki, M. and Araki, K.
LincRNA-p21 exon 1 expression correlates with Cdkn1a expression in vivo.
Genes to Cells 2022;27:14-24. DOI:10.1111/gtc.12906 - Liu N, Iijima A, Iwata Y, Ohashi K, Fujisawa N, Sasaoka T, Hasegawa I.
Mental construction of object symbols from meaningless elements by Japanese macaques (Macaca fuscata).
Scientific Reports 2022;12:3566. DOI:10.1038/s41598-022-07563-z - Tao, H.,# Mori, T.,# Chen, H., Lyu, S., Nonoyama, A., Lee, S., Abe, I. (#equall contribution)
Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/α-ketoglutarate-dependent oxygenase SptF.
Nature Commun 2022;13:95. DOI:10.1038/s41467-021-27636-3 - Sayaka Saijo, Mikiko Ohno, Hirotaka Iwasaki, Shintaro Matsuda, Kiyoto Nishi, Yoshinori Hiraoka, Natsuki Ide, Takeshi Kimura, Eiichiro Nishi
Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis.
Scientific Reports 2022;12:3449. DOI:10.1038/s41598-022-07379-x - N Kondo, Y Sakurai, T Takata, K Kano, K Kume, M Maeda, N Takai, S Suzuki et al.,
Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation.
scientific reports 2022;12:8718. DOI:10.1038/s41598-022-12293-3 - Miyajima K, Sudo Y, Sanechika S, Hara S, Inoue K, Takada M, Yoshioka N, Takebayashi H, Sugimoto M, Sumi-Ichinose C, Takao K, Miyakawa T, Ichinose H, et al.
Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin.
Journal of Neurochemistry 2022;161(2):129-145. DOI:10.1111/jnc.15600 - Megumi Saito, Akane Sada, Masaki Fukuyo, Kiyono Aoki, Kazuhiro Okumura, Yuko Tabata, Yu Chen, Atsushi Kaneda, Yuichi Wakabayashi, Rieko Ohki
PHLDA3 Is an Important Downstream Mediator of p53 in Squamous Cell Carcinogenesis.
Journal of Investigative Dermatology 2022;142:1040-1049. DOI:10.1016/j.jid.2021.09.007 - Mishima Y, Han P, Ishibashi K, Kimura S, and Iwasaki S
Ribosome slowdown triggers codon-mediated mRNA decay independently of ribosome quality control.
EMBO J. 2022;41(5):e109256. DOI:10.15252/embj.2021109256 - Miyake T, Doi M
Roles of the Circadian Clock Mechanism in the Regulation of Daily Rhythms of Body Temperature.
Brain and nerve 2022;74:159-166. DOI:10.11477/mf.1416202001 - Wu Q, Shichino Y, Abe T, Suetsugu T, Omori A, Kiyonari H, Iwasaki S, and Matsuzaki F
Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells.
Nat Commun. 2022;13(1):470. DOI:10.1038/s41467-022-28097-y - Ishiguro K
Sexually dimorphic properties in meiotic chromosome.
Sexual Development 2022:in press. DOI:10.1159/000520682 - Hidekazu Sotoyama, Hiroyoshi Inaba, Yuriko Iwakura, Hisaaki Namba, Nobuyuki Takei, Toshikuni Sasaoka, Hiroyuki Nawa
The dual role of dopamine in the modulation of information processing in the prefrontal cortex underlying social behavior.
The FASEB Journal 2022;36:e22160. DOI:10.1096/fj.202101637R. - Fujita T, Yokoyama T, Shirouzu M, Taguchi H, Ito T, and Iwasaki S
The landscape of translational stall sites in bacteria revealed by monosome and disome profiling.
RNA 2022;28(3):290-302. DOI:10.1261/rna.078188.120 - Hiramatsu Y, Suzuki K, Nishida T, Onoda N, Satoh T, Akira S, Ikawa M, Ikeda H, Kamei J, Derouiche S, Tominaga M, Horiguchi Y
The mechanism of pertussis cough revealed by the mouse-coughing model.
mBio 2022;13:e0319721. DOI:10.1128/mbio.03197-21 - Danjo Y, Shinozaki Y, Natsubori A, Kubota Y, Kashiwagi K, Tanaka KF, Koizumi S.
The Mlc1 promotor directs Müller cell-specific gene expression in the retina.
translational vision science & technology 2022;11:25. DOI:10.1167/tvst.11.1.25 - Morimoto y, Tokumitsu A, ., Shigeki Ohta
TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF).
Neurochem Res 2022:in press. DOI:10.1007/s11064-022-03629-6 - Masai, H.
TT-pocket/HIRAN: binding to 3’-terminus of DNA for recognition and processing of stalled replication forks.
J. Biochem. 2022:in press. DOI:10.1093/jb/mvac042 - Naoto Hori, Yuki Takakura, Ayumi Sugino, Shuto Iwasawa, Kota Nomizo, Naoto Yamaguchi, Hiroyuki Takano, Noritaka Yamaguchi
Vestigial-like family member 3 (VGLL3) stimulates cell motility by inducing High mobility group AT-hook 2 (HMGA2) expression in cancer cells.
Journal of Cellular and Molecular Medicine 2022;26(9):2686-2697. DOI:10.1111/jcmm.17279 - 中村 加枝, 石井 宏憲, 安田 正治
【意思決定と行動選択の神経科学】セロトニンと意思決定.
Clinical Neuroscience 2021;39(8):979-983. - Lauren C Briere, Melissa A Walker, Frances A High, Cynthia Cooper, .., Masaaki Komatsu (19人中１８番目), David A Sweetser
A description of novel variants and review of phenotypic spectrum in UBA5-related early epileptic encephalopathy.
Cold Spring Harb Mol Case Stud 2021;7:a005827. DOI:10.1101/mcs.a005827 - Jin Lee, Xiaoxi Chen, Yuming Wang, Tatsunori Nishimura, Mengjiao Li, Satoko Ishikawa, Takiko Daikoku, Junya Kawai, Arinobu Tojo, Noriko Gotoh
A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer.
Biochem Biophys Res Commun 2021;584:7-14. DOI:10.1016/j.bbrc.2021.11.001 - Miyanishi H, Nitta A
A role of BDNF in the depression pathogenesis and a potential target as antidepressant: the modulator of stress sensitivity "Shati/Nat8l-BDNF system" in the dorsal striatum.
Pharmaceuticals 2021;14:889. DOI:10.3390/ph14090889 - Kawai, F., Ohkuma, M., Horiguchi, M., Ichinose, H., and Miyachi, E.I.
A subset of cone bipolar cells expresses the Na(+) channel SCN2A in the human retina.
Exp. Eye Res. 2021;202:108299. DOI:10.1016/j.exer.2020.108299 - Kazuhiro Okumura(責任著者), Megumi Saito, Yuichi Wakabayashi
A wild-derived inbred mouse strain, MSM/Ms, provides insights into novel skin tumor susceptibility genes.
Experimental Animals 2021;70(3):272-283. DOI:10.1538/expanim.21-0017 - Fukushima, H., Zhang, Y., Kida, S.*
Active transition of fear memory phase from reconsolidation to extinction through ERK-mediated prevention of reconsolidation.
J. Neurosci. 2021;41:1288-1300. DOI:10.1523/JNEUROSCI.1854-20.2020 - Tanaka, M., Shigetomi, E., Parajuli, B., Nagatomo, H., Lee, JH., Kim, SK., Nabekura, J., Koizumi, S. et al.
Adenosine A2B receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
GLIA 2021;69:2546-2558. DOI:10.1002/glia.24006 - Mizuno M, Khaledian B, Maeda M, Hayashi T, Mizuno S, Kono S, Okada S, Suzuki M, Takao S, Minami H, Asai N, Sugiyama F, Takahashi S, Shimono Y, et al.
Adipsin-Dependent Secretion of Hepatocyte Growth Factor Regulates the Adipocyte-Cancer Stem Cell Interaction.
Cancers 2021;13:e4238. DOI:10.3390/cancers13164238 - Hirai I, Funakoshi T, Kamijuku H., Ohta S, Fujita T, Tanosaki R, Handa M, Okamoto S, Amagai M, Kawakami Y.
Adoptive cell therapy using tumor-infiltrating lymphocytes for melanoma refractory to immune-checkpoint inhibitors.
Cancer Sci 2021;112:3163-3172. DOI:10.1111/cas.15009 - Jingushi K, Aoki M,Kawahara K, Furukawa T, Tsujikawa K et al.
ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer.
Sci Rep 2021;11:8677-8677. DOI:10.1038/s41598-021-87763-1 - Shun Hamada, Masashi Nagase, Tomohiko Yoshizawa, Akari Hagiwara, Yoshikazu Isomura, Ayako M Watabe, Toshihisa Ohtsuka.
An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping.
Communications Biology 2021;4:461. DOI:10.1038/s42003-021-01977-7 - Taichi Sugawara, Kyoko Furuse, Tetsuhisa Otani, Tomohiko Wakayama, Mikio Furuse
Angulin-1 seals tricellular contacts independently of tricellulin and claudins.
Journal of Cell Biology 2021;220:e202005062. DOI:10.1083/jcb.202005062 - Yusuke Murakami, Ryutaro Fukui, Reika Tanaka, Yuji Motoi, Atsuo Kanno, Ryota Sato, Kiyoshi Yamaguchi, Yoichi Furukawa,Naomi Yamashita, Kensuke Miyake
Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes.
Frontiers in Immunology 2021;12:777197. DOI:10.3389/fimmu.2021.777197.eCollection2021 - Shinichi Nakagawa, Tomohiro Yamazaki, Taro Mannen, Tetsuro Hirose
ArcRNAs and the formation of nuclear bodies.
Mammalian Genomes 2021;33:382-401. DOI:10.1007/s00335-021-09881-5 - Bunno, T., Awakawa, T., Mori, T., Abe, I.
Aziridine formation by a Fe(II)/α-ketoglutarate dependent oxygenase and 2-aminoisobutyrate biosynthesis in fungi.
Angew. Chem. Int. Ed. 2021;60:15827-15831. DOI:10.1002/anie.202104644 - Nagata T, Minami K, Yamamoto M, Hiraki T, Idogawa M, Fujimoto K, Kageyama S, Tabata K, Kawahara K, Furukawa T, Sato M et al.
BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma.
Int J Mol Sci. 2021;22:11509. DOI:10.3390/ijms222111509 - Nakajima K, Ishiwata M, Weitemier AZ, Shoji H, Monai H, Miyamoto H, Yamakawa K, Miyakawa T, McHugh TJ, Kato T
Brain-specific heterozygous loss-of-function of ATP2A2, endoplasmic reticulum Ca2+ pump responsible for Darier’s disease, causes behavioral abnormalities and a hyper-dopaminergic state.
Human Molecular Genetics 2021;30:1762-1772. DOI:10.1093/hmg/ddab137 - Komeno M, Pang X, Shimizu A, .., Ogita H.
Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice.
J Biol Chem 2021;296:100761. DOI:10.1016/j.jbc.2021.100761 - Sato A, Rahman NIA, Shimizu A, Ogita H.
Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
Cancer Sci 2021;112:4005-4012. DOI:10.1111/cas.15114 - Mori, T., Abe, I., Toshiya, S., Kobayashi, M. et al.
C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes.
Nature Commun. 2021;12:6294. DOI:10.1038/s41467-021-26585-1 - Masashi Kawami, Shinnosuke Takenaka, Mizuki Akai, Ryoko Yumoto, Mikihisa Takano
Characterization of miR-34a-inudced epithelial-mesenchymal transition in Non-small lung cancer cells focusing on p53.
Biomolecules 2021;11:1853. DOI:10.3390/biom11121853 - Chukai Y, Iwamoto T, Itoh K, Tomita H, Ozaki T
Characterization of mitochondrial calpain-5.
Biochim Biophys Acta Mol Cell Res 2021;1868(5):118989. DOI:10.1016/j.bbamcr.2021.118989 - Yasushi Takemoto, Shin Kadota, Itsunari Minami, Shinya Otsuka, Satoshi Okuda, Masahiro Abo, Louvy Lynn Punzalan, Yan Shen, Yuji Shiba, Motonari Uesugi
Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis.
Angewandte Chemie International Edition 2021;60:21824-21831. DOI:10.1002/anie.202100523 - Seimiya H, Nagasawa K, Shin-Ya K
Chemical targeting of G-quadruplexes in telomeres and beyond for molecular cancer therapeutics.
J Antibiot 2021;74:617-628. DOI:10.1038/s41429-021-00454-x - Haryono A, Ikeda K, Nugroho D, Ogata T, Tsuji Y, Matoba S, Moriwaki K, Kitagawa H, Igarashi M, Hirata K, Emoto N
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 plays a cardioprotective role in heart failure caused by acute pressure overload.
J Am Heart Assoc 2021;11(7):e023401. DOI:10.1161/JAHA.121.023401 - Hou X*, Nozumi M, Nakamura H, Igarashi M, Sugiyama S*
Coactosin Promotes F-actin Protrusion in Growth Cones under Cofilin-related Signaling Pathway.
Front Cell Dev Biol 2021;9:660349. DOI:10.3389/fcell.2021.660349 - Ichihara K, Matsumoto A, Nishida H, Kito Y, Shimizu H, Shichino Y, Iwasaki S, Imami K, Ishihama Y, and Nakayama KI.
Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons.
Nucleic Acids Res 2021:gkab549. DOI:10.1093/nar/gkab549 - Katsuya Uchida and Mao Suzuki
Congenital Hypothyroidism and Brain Development: Association with Other Psychiatric Disorders.
Frontiers in Neuroscience 2021;15:772382. DOI:10.3389/fnins.2021.772382 - Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Motegi SI, Tokunaga F, Ishikawa O.
Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease.
Sci Rep. 2021;11:23146. DOI:10.1038/s41598-021-02522-6 - Miyashita H, Oikawa D, Terawaki S, Kabata D, Shintani A, Tokunaga F.
Crosstalk between NDP52 and LUBAC in innate immune responses, cell death, and xenophagy.
Front Immunol. 2021;12:635475. DOI:10.3389/fimmu.2021.635475 - Simankova A, Bizen N, Saitoh S, Shibata S, Ohno N, Abe M, Sakimura K, Takebayashi H.
Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression.
Glia 2021;69:2559-2574. DOI:10.1002/glia.24058 - Murakami R, Sumiyoshi T, Negishi L, Siomi MC.
DEAD‐box polypeptide 43 facilitates piRNA amplification by actively liberating RNA from Ago3‐piRISC.
EMBO Rep. 2021;22:e51313. DOI:10.15252/embr.202051313 - Naniwa, K. and Aonuma H.
Descending and ascending signals that maintain rhythmic walking pattern in the cricket.
Frontiers in Robotics and AI 2021;8:625094. DOI:10.3389/frobt.2021.625094 - Daikuzono H, Yamazaki M, Sato Y, Takahashi T, Yamagata K
Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes.
Biochem Biophys Res Commun. 2021;578:170-176. DOI:10.1016/j.bbrc.2021.08.054 - Kogaki T, Ohshio I,Kawahara K, Furukawa T, Jingushi K, Tsujikawa K et al.
Development of a highly sensitive method for the quantitative analysis of modified nucleosides using UHPLC-UniSpray-MS/MS.
J Pharm Biomed Anal 2021;197:113943-113943. DOI:10.1016/j.jpba.2021.113943 - Watanabe Y, Sugano E, Tabata K, Hatakeyama A, Sakajiri T, Fukuda T, Ozaki T, Suzuki T, Sayama T, Tomita H
Development of an optogenetic gene sensitive to daylight and its implications in vision restoration.
npj Regenerative Medicine 2021;6(1):64. DOI:10.1038/s41536-021-00177-5 - Tsuji, R., Inoue, H., Uehara, M., Kida, S.*
Dietary magnesium deficiency induces the expression of neuroinflammation-related genes in mouse brain.
Neuropsychopharmacol Rep. 2021;41:230-236. DOI:10.1002/npr2.12167 - Irie, T., Asami, T., Sawa, A., Uno, Y., Taniyama, C., Funakoshi, Y., Masai, H., Sawa, M.
Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers.
J. Med. Chem. 2021;64:14153-14164. DOI:10.1021/acs.jmedchem.1c01319 - Yuta Arai, Hiroki Oguri*
Divergent synthesis of functionalized dihydropyridines and pyrroles via metal-free one-pot domino reactions of a gem-disubstituted propargyl amine and an alkynyl sulfone.
Tetrahedron Lett. 2021 2021;78:153283. DOI:10.1246/cl.200920 - Toyokuni S, Kong Y, Zheng H, Mi D, Katabuchi M, Motooka Y, Ito F.
Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles.
J Cancer Prev 26: 244-249, 2021 2021;26:244-249. DOI:10.15430/JCP.2021.26.4.244 - Uchida M, Noda Y, Hasegawa S, Hida H, Taniguchi M, Mouri A, Yoshimi A, Nabeshima T, Yamada K, Aida T, Tanaka K, Ozaki N.
Early postnatal inhibition of GLAST causes abnormalities of psychobehaviors and neuronal morphology in adult mice.
Neurochem Int. 2021;150:105177. DOI:10.1016/j.neuint.2021.105177 - Kashiwagi K, Shichino Y, Osaki T, Sakamoto A, Nishimoto M, Takahashi M, Mito M, Weber F, Ikeuchi Y, Iwasaki S, and Ito T
eIF2B-capturing viral protein NSs suppresses the integrated stress response.
Nat Commun. 2021;12(1):7102. DOI:10.1038/s41467-021-27337-x - Yang, P., Tian, H., Zou, Y.R., Chambon, P., Ichinose, H., Honig, G., Diamond, B., and Kim, S.J.
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Front Immunol 2021;12:616583. DOI:10.3389/fimmu.2021.616583 - Kitakaze, M., Chijimatsu, R., Vecchione, A., Kitagawa, T., Doki, Y., Eguchi, H., Ishii, H.
Epithelial cell transformation and senescence as indicators of genome aging: current advances and unanswered questions.
Int. J. Mol. Sci. 2021;22:7544. DOI:10.3390/ijms22147544 - Naho Nomura, Chiaki Ito, Takako Ooshio1, .., Masaaki Komatsu(15人中13番目), ToruYanagawa, Atsushi Hirao
Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner.
Scientific Reports 2021;11:1666. DOI:10.1038/s41598-021-81076-z - Yusuke Hanaki, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita
Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions.
Fundamental Toxicological Sciences 2021;8(3):69-73. DOI:10.2131/fts.8.69 - Shepherd S., Jackson C.W., Sharkh S.M., Aonuma H., Oliveira E.E. and Newland P.L.
Extremely low-frequency electromagnetic fields entrain locust wingbeats.
Bioelectromagnetics 2021;42:296-308. DOI:10.1002/bem.22336 - Ishizaki Y., Higuchi T., Yanagimoto Y., Kobayashi H., Noritake A., Nakamura K., Kaneko K.
Eye gaze differences in school scenes between preschool children and adolescents with high-functioning autism spectrum disorder and those with typical development.
BioPsychoSocial medicine 2021;15(1):2-2. DOI:10.1186/s13030-020-00203-w - Grigor Varuzhanyan, Mark S Ladinsky, Shun-Ichi Yamashita, Manabu Abe, Kenji Sakimura, Tomotake Kanki, David C Chan
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.
Development 2021;148:dev199686. DOI:10.1242/dev.199686 - Hoshino C, Konno A, Hosoi N, Kaneko R, Mukai R, Nakai J, Hirai H.
GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter.
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Gata3 is essential for separating patterning domains during facial morphogenesis.
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Genetic polymorphisms of lysophosphatidic acid receptor 1 are associated with the onset of taxane-induced peripheral neuropathy.
British Journal of Anaesthesia 2021;127:43-46. DOI:10.1016/j.bja.2021.04.014 - Yamaguchi Y, Murai I, Goto K, Doi S, Zhou H, Setsu G, Shimatani H, Okamura H, Miyake T, Doi M
Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.
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Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion.
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Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
Hepatology 2021;73:2527-2545. DOI:10.1002/hep.31752 - Wakabayashi, T., Nakamura, S., Nakao, Y., Yamato, S., Htun, Y., Mitsuie, T., Morimoto, A., Arioka, M., Koyano, K., Konishi, Y., Miki, T., Ueno, M., Kusaka, T.
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Pediatric International 2021;64(1):e14961. DOI:10.1111/ped.14961 - Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Nogawa T, Okano A, Hashizume D, Osada H.
Identification of a small-molecule glucose transporter inhibitor, glutipyran, that inhibits cancer cell growth.
ACS Chem Biol 2021;16:1576-1586. DOI:10.1021/acschembio.1c00480 - Kawatani M, Aono H, Shimizu T, Ohkura S, Hiranuma S, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Yamazaki K, Dan S, Osada H.
Identification of dihydroorotate dehydrogenase inhibitors-indoluidins-that inhibit cancer cell growth.
ACS Chem Biol 2021;16:2570-2580. DOI:10.1021/acschembio.1c00625 - Xiao Min Zhang, Tatsushi Yokoyama, Masayuki Sakamoto
Imaging Voltage with Microbial Rhodopsins.
Frontiers in Molecular Biosciences 2021;8 DOI:10.3389/fmolb.2021.738829 - Munirah I, Ozaki T, Sekine A, Morimoto M, Sugawara M, Takada H, Sugano E, Tomita H, Kiyono T, Fukuda T
Immortalization of cells derived from domestic dogs through expressing mutant cyclin-dependent kinase 4, cyclin D1, and telomerase reverse transcriptase.
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Immunomodulation by Inflammation during Liver and Gastrointestinal Tumorigenesis and Aging.
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FASEB J 2021;36(2):e22123. DOI:10.1096/fj.202101389R - Takeda, Y., Chijimatsu, R., Vecchione, A., Arai, T., Kitagawa, T., Ofusa, K., Yabumoto, M., Hirotsu, T., Eguchi, H., Doki, Y., Ishii, H.
Impact of one-carbon metabolism-driving epitranscriptome as a therapeutic target for gastrointestinal cancer.
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Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice.
Molecular Brain 2021;14:170. DOI:10.1186/s13041-021-00879-3 - Sato T*, Oda K, Sakai S, Kato R, Yamamori S, Itakura M, Kodera Y, Nishizawa M, Sasaoka T, Onodera O, Yokoyama M
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Scientific Reports 2021:in press. DOI:10.21203/rs.3.rs-1113360/v1 - Kaneko R, Kakinuma T, Sato S, Jinno-Oue A.
Improvement of short straws for sperm cryopreservation: installing an air-permeable filter facilitates handling.
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Cancer sci 2021;112:1390-1401. DOI:10.1111/cas.14812 - Fukushima, H., Zhang, Y., Kida, S.*
Interactions between the amygdala and medial prefrontal cortex as upstream regulators of the hippocampus to reconsolidate and enhance retrieved inhibitory avoidance memory.
Mol Brain 2021;14(1):44. DOI:10.1186/s13041-021-00753-2 - Shimizu K, Gi M, Suzuki S, North BJ, Watahiki A, Fukumoto S, Asara JM, Tokunaga F, Wei W, Inuzuka H.
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Interstitial axon collaterals of callosal neurons form association projections from the primary somatosensory to motor cortex in mice.
Cereb. Cortex 2021;31:5225-5238. DOI:10.1093/cercor/bhab153 - Itoh Y., Itoh S., Naruse H., Kagioka T., Abe M., Hayashi M.
Intracellular density is a novel indicator of different stages of murine osteoblast lineage cells.
Journal of Cellular Biochemistry 2021;122(12):1805-1816. DOI:10.1002/jcb.30135 - Ito T, Hiramatsu Y, Mouri A, Yoshigai T, Takahashi A, Yoshimi A, Mamiya T, Ozaki N, Noda Y.
Involvement of PKCβI-SERT activity in stress vulnerability of mice exposed to twice-swim stress.
Neurosci Res 2021;171:83-91. DOI:10.1016/j.neures.2021.01.002 - Mori Y, Mouri A, Kunisawa K, Hirakawa M, Kubota H, Kosuge A, Niijima M, Hasegawa M, Kurahashi H, Murakami R, Hoshi M, Nakano T, Nabeshima T, Saito K.
Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid.
Behav Brain Res 2021;405:113191. DOI:10.1016/j.bbr.2021.113191 - Owaki D., Aonuma H., Sugimoto Y. and Ishiguro A.
Leg amputation modifies coordinated activation ofthe middle leg muscles in the cricket Gryllus bimaculatus.
Scientific Reports 2021;11:1327. DOI:10.1038/s41598-020-79319-6 - Penisson M, Jin M, Wang S, Hirotsune S, Francis F, Belvindrah R.
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Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion.
eLife 2021;10:e66721. DOI:10.7554/eLife.66721 - Yoshizawa-Sugata, Y., Yamazaki, S., Mita-Yoshida, K., Ono, T., Nishito, Y., and *Masai, H.
Loss of full-length Rif1 protein in 2-cell embryos is associated with zygotic transcriptional activation.
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Loss of P2Y1 receptor triggers glaucoma-like pathology in mice.
British Journal of Pharmacology 2021;178:4552-4571. DOI:10.1111/bph.15637 - Nishida R, Kawaguchi Y, Matsubayashi J, Ishikawa R, Kida S, Takei K.
LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation.
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Manganese Dynamics in Mouse Brain After Systemic MnCl2 Administration for Activation-Induced Manganese-Enhanced MRI.
Frontiers in Neural Circuits 2021;15:787692. DOI:10.3389/fncir.2021.787692 - Ishiguro K, Shimada R.
MEIOSIN directs initiation of meiosis and subsequent meiotic prophase programs during spermatogenesis.
Genes and Genetic Systems 2021;96 DOI:10.1266/ggs.21-00054 - Horisawa-Takada Y, Kodera C, Takemoto K, Sakashita A, Horisawa K, Maeda R, Shimada R, et al, Araki K, Ishiguro K.
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Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis.
Nat Struct Mol Biol 2021;28:583-593. DOI:10.1038/s41594-021-00614-5 - Tomofumi Watanabe, Kazuhiro Sakamoto
Meta-analysis of cognitive and behavioral tests in leptin- and leptin receptor-deficient mice.
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Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient.
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MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function.
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Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment.
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/ mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes.
J Immunother Cancer 2021;9:e002954. DOI:10.1136/jitc-2021-002954 - Mori, T., Zhai, R., Ushimaru, R., Matsuda, Y., Abe, I.
Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI.
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Multiple nicotinic acetylcholine receptor subtypes regulate social or cognitive behaviors in mice repeatedly administered phencyclidine.
Behav Brain Res 2021;408:113284. DOI:10.1016/j.bbr.2021.113284 - Kudo T., Aonuma H. and Hasegawa E.
Mutual selfish manipulation enhances mutualism in an aphid-ant symbiosis.
Scientific Reports 2021;11:18569. DOI:10.1038/s41598-021-97666-w - Iguchi T, Oka Y, Yasumura M, Omi M, Kuroda K, Yagi H, Xie MJ, Taniguchi M, Bastmeyer M, Sato M.
Mutually repulsive EphA7-EfnA5 organize region-to-region corticopontine projection by inhibiting collateral extension.
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Neurexins in serotonergic neurons regulate serotonin release and complex mouse behaviors.
bioRxiv 2021:in press. DOI:10.1101/2021.12.09.471904 - Atsushi Chiba, Kazunori Morita, Ken‑ichi Oshio, Masahiko Inase
Neuronal activity in the monkey prefrontal cortex during a durationdiscrimination task with visual and auditory cues.
Scientific Reports 2021;11:17520. DOI:10.1038/s41598-021-97094-w - Mashima T, Wakatsuki T, Kawata N, Jang MK, Nagamori A, Yoshida H, Nakamura K, Migita T, Seimiya H, Yamaguchi K
Neutralization of the induced VEGF-A potentiates the therapeutic effect of an anti-VEGFR2 antibody on gastric cancer in vivo.
Sci Rep 2021;11:15125. DOI:10.1038/s41598-021-94584-9 - Izuo N, Nitta A
New Insights regarding diagnosis and medication for schizophrenia based on neuronal synapse-microglia interaction.
J Pers Med 2021;11:371. DOI:10.3390/jpm11050371 - Izumi S, Domoto M, Esaki H, Sasase H, Nishitani N, Deyama S, Kaneda K
Nicotine enhances firing activity of layer 5 pyramidal neurons in the medial prefrontal cortex through inhibition of Kv7 channels.
Biological and Pharmaceutical Bulletin 2021;44:724-731. DOI:10.1248/bpb.b21-00137 - Esaki H, Izumi S, Fukao A, Nishitani N, Deyama S, Kaneda K
Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice.
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Nicotine enhances object recognition memory via stimulating α4β2 and α7 nicotinic acetylcholine receptors in the medial prefrontal cortex of mice.
Biological and Pharmaceutical Bulletin 2021;44:1007-1013. DOI:10.1248/bpb.b21-00314 - Tao, H., Mori, T., Wei, X., Matsuda, Y., Abe, I.
One polyketide synthase, two distinct products: trans-acting enzyme-controlled product divergence in calbistrin biosynthesis.
Angew. Chem. Int. Ed. 2021;60:8851-8858. DOI:10.1002/anie.202016525 - Yusuke Hanaki, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita
Oscillatoxin E and its C7 epimer show distinct growth inhibition profiles against several cancer cell lines.
Heterocycles 2021;102:2353-2362. DOI:10.3987/COM-21-14538 - Eskelinen EL, Kageyama S, Komatsu M
p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control.
Mol Cell Oncol 2021;8:1890990. DOI:10.1080/23723556.2021.1890990 - Shun Kageyama, Sigurdur Runar Gudmundsson, .. Satoshi Waguri, Eeva-Liisa Eskelinen, Masaaki Komatsu
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.
Nature Communications 2021;12:1-16. DOI:10.1038/s41467-020-20185-1 - Miyata K, Imai Y, Hori S, Toyokuni S, Sakata T, Shirahige K, Kojima R, Nakayama M, Oshima M, Nagayama S, Seimiya H, Hirota T, Saya H, Hara E, Takahashi A et al.
Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
Proc Natl Acad Sci U S A 2021;118:e2025647118. DOI:10.1073/pnas.2025647118 - Wulaer B, Kunisawa K, Tanabe M, Yanagawa A, Saito K, Mouri A, Nabeshima T.
Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice.
Mol Brain. 2021;14:43. DOI:10.1186/s13041-021-00760-3 - Tabata K, Sugano E, Hatakeyama A, Watanabe Y, Suzuki T, Ozaki T, Fukuda T, Tomita H
Phototoxicities Caused by Continuous Light Exposure Were Not Induced in Retinal Ganglion Cells Transduced by an Optogenetic Gene.
Int J Mol Sci 2021;22(13):6732. DOI:10.3390/ijms22136732 - Kawasaki A, Sakai A, Nakanishi H, Hasegawa J, Taguchi T, Sasaki J, Arai H, Sasaki T, Igarashi M, *Nakatsu F
PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission.
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PKCδ deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCδ knockout mice.
PLOS ONE 2021;16(7):e0253912. DOI:10.1371/journal.pone.0253912 - Yuko Nagamura, Makoto Miyazaki, Yoshiko Nagano, Masako Yuki, Kiyoko Fukami, Kazuyoshi Yanagihara, Kazuki Sasaki, Ryuichi Sakai, and Hideki Yamaguchi
PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification.
Oncogenesis 2021;10:25. DOI:10.1038/s41389-021-00314-1 - Ohi K, Nishizawa D, Sugiyama S, Takai K, Kuramitsu A, Hasegawa J, Soda M, Kitaichi K, Hashimoto R, Ikeda K, Shioiri T.
Polygenic Risk Scores Differentiating Schizophrenia From Bipolar Disorder Are Associated With Premorbid Intelligence in Schizophrenia Patients and Healthy Subjects.
Int J Neuropsychopharmacol 2021;24(7):562-569. DOI:10.1093/ijnp/pyab014 - Scibelli A.E., Caron D.P, Aonuma H., Trimmer B.A.
Proleg retractor muscles in Manduca sexta larvae are segmentally different suggesting anteroposterior specialization.
Journal of Experimental Biology 2021;224:jeb242508. DOI:10.1242/jeb.242508 - Muroi M, Osada H.
Proteomics-based target identification of natural products affecting cancer metabolism.
J Antibiot 2021;74:639-650. DOI:10.1038/s41429-021-00437-y - Ono R.*, Abe M.*, Koike N., Inokawa H., Tuchiya Y., Umemura Y., Sasawaki Y., Yamamoto T., Wakisaka S., Kanamura N., Yagita K.
Quantitative morphometric analysis of molar teeth and alveolar bone in aged mice using micro-computed tomography.
Journal of Oral Bioscience 2021;63(3):265-270. DOI:10.1016/j.job.2021.07.006 - Shinsuke Fujii, Takuma Ishibashi, Megumi Kokura, Tatsufumi Fujimoto, Shinji Matsumoto, ..Tamotsu Kiyoshima
RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation.
The Journal of pathology 2021;256:119-133. DOI:10.1002/path.5814 - Takahashi H, Asahina R, Fujioka M, Matsui TK, Kato S, Mori E, Hioki H, Yamamoto T, Kobayashi K, Tsuboi A
Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
Proc. Natl. Acad. Sci. USA. 2021;118:e2018850118. DOI:10.1073/pnas.2018850118 - Ryo Ninokata, Riho Korogi, Junya Nakao, Tsutomu Fukuda, Gen Onodera, Masanari Kimura
Reconstruction of Carbon Bond Frameworks via Oxapalladacycle Promoted by Synergistic Effect of Palladium Catalyst and Triethylborane.
Synthesis 2021;53:3110-3120. DOI:10.1055/a-1485-5781 - Oki M, Masai H.
Regulation of HP1 protein by phosphorylation during transcriptional repression and cell cycle.
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Regulation of neutrophil functions by Hv1/VSOP voltage-gated proton channels.
International Journal of Molecular Sciences 2021;22:2620. DOI:10.3390/ijms22052620 - Kaori Oka（研究代表者、共第一著者）, Shusuke Fujioka（共第一著者）, Yoshimi Kawamura（共第一著者）, Kimi Araki（研究協力者）Kyoko Miura（責任著者） et al.
Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats.
bioRxiv 2021:in press. DOI:10.1101/2021.10.21.465383 - Iwakawa HO, Lam YWA, Mine A, Fujita T, Kiyokawa K, Yoshikawa M, Takeda A, Iwasaki S, and Tomari Y.
Ribosome stalling caused by the Argonaute-miRNA-SGS3 complex regulates production of secondary siRNA biogenesis in plants.
Cell Rep 2021;35:109300. DOI:10.1016/j.celrep.2021.109300 - Toyokuni S, Ito F, Motooka Y
Role of ferroptosis in nanofiber-induced carcinogenesis.
Metallomics Res 2021;1:#MR202102. - Hsiao H-W, Yang C-C, Masai H
Roles of Claspin in regulation of DNA replication, replication stress responses and oncogenesis in human cells.
Genome Instability & Disease 2021;2:263-280. DOI:10.1007/s42764-021-00049-8 - 2） Asai, A., Konno, M., Ozaki, M., Kawamoto, K., Chijimatsu, R., Kondo, N., Hirotsu, T., Ishii, H.
Scent test using caenorhabditis elegans to screen for earlystage pancreatic cancer.
Oncotarget 2021;12:1687-1696. DOI:10.18632/oncotarget.28035 - Nitta A, Izuo N, Hamatani K, Inagaki R, Kusui Y, Fu K, Asano T, Torii Y, Habuchi C, Sekiguchi H, Iritani S, Muramatsu SI, Ozaki N, Miyamoto Y.
Schizophrenia-like behavioraliImpairments in mice with suppressed expression of Piccolo in the medial prefrontal cortex.
J Pers Med. 2021;11 DOI:10.3390/jpm11070607 - Mohammad Omar Faruk, Yoshinobu Ichimura, Masaaki Komatsu
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Cancer Science 2021;112:3972-3978. DOI:10.1111/cas.15112 - Makino S, Kawamata T, Iwasaki S, and Ohsumi Y
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Nat Commun 2021;12(1):2316. DOI:10.1038/s41467-021-22574-6 - Saeki N., Inui-Yamamoto C., Kuraki M., Itoh S., Inubushi T., Okamoto M., Akiyama S., Wakisaka S., Abe M.
Senescence-accelerated mouse prone 8 (SAMP8) mice exhibit reduced entoconid in the lower second molar.
Archives of Oral Biology 2021;128:105172. DOI:10.1016/j.archoralbio.2021.105172 - Kimura Y, Izumiya Y, Araki S, Yamamura S, Hanatani S, Onoue Y, Ishida T, Arima Y, Nakamura T, Bober E, Braun T, Kaikita K, Yamagata K, Tsujita K
Sirt7 deficiency attenuates neointimal formation following vascular injury by modulating vascular smooth muscle cells proliferation.
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SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARg2.
J Diabetes Investig 2021;12(10):1765-1774. DOI:10.1111/jdi.13567 - Kaiwen Liu, Ryota Sato, Takuma Shibata, Ryosuke Hiranuma, Tatjana Reuter, Takeshi Ichinohe, Manabu Ozawa, Nobuaki Yoshida, Eicke Latz, Kensuke Miyake
Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.
International Immunology 2021;33(9):479-490. DOI:10.1093/intimm/dxab033 - Yoshimoto R, Chhipi Shrestha JK, .. Iwasaki S, and Yoshida M
Spliceostatin A interaction with SF3B1 limits U1 snRNP availability and causes premature cleavage and polyadenylation.
Cell Chem Biol 2021;28:1356-1365. DOI:10.1016/j.chembiol.2021.03.002 - Chhipi Shrestha JK, Schneider-Poetsch T, Suzuki T, Mito M, Khan K, Dohmae N, Iwasaki S, and Yoshida M
Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns.
Cell Chem Biol. 2021;29(2):259-275. DOI:10.1016/j.chembiol.2021.07.015 - Ryo Ishikawa, Mizuho Yasuda, Shogo Sasaki, Yue Ma, Kazuo Nagasawa, Masayuki Tera
Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease.
Chem. Commun., 2021;57:7236-7239. DOI:10.1039/D1CC03294A - Shimo, S., Ushimaru, R., Engelbrecht, A., Harada, M., Miyamoto, K., Andreas, K., Uchiyama, M., Kaysser, L., Abe, I.
Stereodivergent nitrocyclopropane formation during biosynthesis of belactosins and hormaomycins.
J. Am. Chem. Soc. 2021;143:18413-18418. DOI:10.1021/jacs.1c10201 - Miyanishi H, Muramatsu SI, Nitta A
Striatal Shati/Nat8l-BDNF pathways determine the sensitivity to social defeat stress in mice through epigenetic regulation.
Neuropsychopharmacology 2021;14:1594-1605. DOI:10.1038/s41386-021-01033-2 - Yang, J., Mori, T., Wei, X., Matsuda, Y., Abe, I.
Structural basis for isomerization reactions in fungal tetrahydroxanthone biosynthesis and diversification.
Angew. Chem. Int. Ed. 2021;60:19458-19465. DOI:10.1002/anie.202107884 - Shepherd S., Lima M.A.P., Oliveira E.E., Sharkh S.M., Aonuma H., Jackson C.W., and Newland P.L.
Sublethal neonicotinoid exposure attenuates the effects of electromagnetic fields on honey bee flight and learning.
Environmental Advances 2021;4:100051. DOI:10.1016/j.envadv.2021.100051 - Hiroki Oguri*
Synthesis and Structural Diversification of Artemisinins Towards the Generation of Potent Anti-malarial Agents.
Chem. Lett. 2021;50:924-937. DOI:10.1246/cl.200920 - Kumiko Yoshinobu, Masatake Araki, Ayaka Morita, Miyuki Araki, Shun Kokuba, Naomi Nakagata, Kimi Araki
Tamoxifen feeding method is suitable for efficient conditional knockout.
Exp Anim 2021;70:91-100. DOI:10.1538/expanim.19-0138 - Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
Inflamm Res. 2021;70:539-541. DOI:10.1007/s00011-021-01458-x - Iwasaki N, Terawaki S, Shimizu K, Oikawa D, Sakamoto H, Sunami K, Tokunaga F.
Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling.
PLoS One. 2021;16:e0248158. DOI:10.1371/journal.pone.0248158 - Kimura R, Yoshimura Y
The contribution of low contrast–preferring neurons to information representation in the primary visual cortex after learning.
Science Advances 2021;7(48):eabj9976. DOI:10.1126/sciadv.abj9976 - Kimura H, Sada R, Takada N, Harada A, Doki Y, Eguchi H, Yamamoto H, Kikuchi A
The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancer.
Oncogene 2021;40:4486-4502. DOI:10.1038/s41388-021-01860-z - Hori, H., Itoh, M., Matsui, M., Kamo, T., Saito, T., Nishimatsu, Y, Kito, S., Kida, S., Kim, Y.
The efficacy of memantine in the treatment of civilian posttraumatic stress disorder: an open label trial.
European Journal of Psychotraumatology 2021;12:1:1859821. DOI:10.1080/20008198.2020.1859821 - Nakayama Jun, Han Yuxuan, Kuroiwa Yuka, Azuma Kazushi, Yamamoto Yusuke, Semba Kentaro,
The In Vivo Selection Method in Breast Cancer Metastasis.
International Journal of Molecular Sciences 2021;22:1886. DOI:10.3390/ijms22041886 - Kazuhiro Okumura(第一著者), Megumi Saito, Eriko Isogai, and Yuichi Wakabayashi(責任著者)
The Japanese Wild-Derived Inbred Mouse Strain, MSM/Ms in Cancer Research.
Cancers (Basel). 2021;13(5):1026. DOI:10.3390/cancers13051026 - Michio Sato, .. Kumiko Yoshinobu, Mai Imasaka, Masatake Araki, .. Kimi Araki, Yuichi Oike
The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis.
Nat Commun 2021;12:2529. DOI:10.1038/s41467-021-22735-7 - Takeuchi Y, Kimura N, Murayama T, et al, Gotoh N
The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis.
Proc. Natl, Acad, Sci, USA 2021;vol.118:e2103658118. DOI:10.1073/pnas.2103658118 - Ryo Yoshikawa, Koichiro Abe
The multi-kinase inhibitor dasatinib suppresses autoinflammation and increases bone density in a mouse model for chronic recurrent multifocal osteomyelitis.
Cell Biochem Funct. 2021;39:521-527. DOI:10.1002/cbf.3617 - Mariko Ito, Masashi Nagase, Suguru Tohyama, Kaori Mikami, Fusao Kato, Ayako M Watabe.
The parabrachial-to-amygdala pathway provides aversive information to induce avoidance behavior in mice.
Molecular Brain 2021;14:94. DOI:10.1186/s13041-021-00807-5 - Nishio N, Hayashi K, Ishikawa AW, Yoshimura Y
The role of early visual experience in the development of spatial-frequency preference in the primary visual cortex.
The Journal of Physiology 2021;599(17):4131-4152. DOI:10.1113/JP281463 - Furuya K, Wu T, Orimoto A, Sugano E, Tomita H, Kiyono T, Kurose T, Takai Y, Fukuda T
The transcriptome of wild-type and immortalized corneal epithelial cells.
Sci Data 2021;8(1):126. DOI:10.1038/s41597-021-00908-9 - Shimatani H, Inoue Y, Maekawa Y, Miyake T, Yamaguchi Y, and Doi M
Thermographic imaging of mouse across circadian time reveals body surface temperature elevation associated with non-locomotor body movements.
PLoS One 2021;16:e0252447. DOI:10.1371/journal.pone.0252447 - Miyahara H, Natsumeda M, Kanemura Y, Yamasaki K, Yoshimura J, Fujii Y, Suenobu S, Ihara K, Hara J, Kakita A, Yoshida M, Iwasaki Y
Topoisomerase IIβ immunoreactivity (IR) co-localizes with neuronal marker-IR but not glial fibrillary acidic protein-IR in GLI3-positive medulloblastomas: an immunohistochemical analysis of 124 medulloblastomas from the Japan Children's Cancer Group.
Brain Tumor Pathol 2021;49(3):527-534. DOI:10.1007/s10014-021-00396-0 - Hiroyuki Saiga, Masaki Ueno, Takashi Tanaka, Tsuneyasu Kaisho, Katsuaki Hoshino
Transcription factor MafB-mediated inhibition of type I interferons in plasmacytoid dendritic cells.
International Immunology 2021:dxab103. DOI:10.1093/intimm/dxab103 - Doi M, Oka Y, Taniguchi M, Sato M.
Transient expansion of the expression region of Hsd11b1, encoding 11β-hydroxysteroid dehydrogenase type 1, in the developing mouse neocortex.
J. Neurochem 2021;159:778-788. DOI:10.1111/jnc.15505 - Nguyen LKC, Shimizu A, Soh JEC, Komeno M, Sato A, Ogita H.
Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through αB-crystallin intracellular dynamics.
J Biochem 2021;170(5):577-585. DOI:10.1093/jb/mvab066 - Takahashi, S., Fukushima, H., Yu, Z., Tomita, H., Kida, S.*
Tumor necrosis factor α negatively regulates the retrieval and reconsolidation of hippocampus-dependent memory.
Brain, Behavior, and Immunity 2021;94:79-88. DOI:10.1016/j.bbi.2021.02.033 - Iori Ohmori, Mamoru Ouchida, Hirohiko Imai, Saeko Ishida, Shinya Toyokuni, Tomoji Mashimo
Txn1 mutation causes epilepsy associated with vacuolar degeneration in the midbrain.
bioRxiv 2021:in press. DOI:10.1101/2021.10.07.463470 - Inukai, S., Hara, S., and Ichinose, H.
Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue.
Biochem. Biophys. Res. Commun. 2021;589:209-214. DOI:10.1016/j.bbrc.2021.12.024 - Kawakami T, Fujisawa H, Nakayama S, Yoshino Y, Hattori S, Seino Y, Takayanagi T, Miyakawa T, Suzuki A, Sugimura Y.
Vasopressin escape and memory impairment in a model of chronic syndrome of inappropriate secretion of antidiuretic hormone in mice.
Endocrine Journal 2021;68:31-43. DOI:10.1507/endocrj.EJ20-0289 - Yuki Takakura, Naoto Hori, Natsumi Terada, Moeka Machida, Naoto Yamaguchi, Hiroyuki Takano, Noritaka Yamaguchi
VGLL3 activates inflammatory responses by inducing interleukin-1α secretion.
FASEB Journal 2021;11:e21996. DOI:10.1096/fj.202100679RR - Yue Ma, Yuki Wakabayashi, Naruyuki Watatani, Ryota Saito, Takatsugu Hirokawa, Masayuki Tera, Kazuo Nagasawa
Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand.
Org. Biomol. Chem 2021;19(37):8035-8040. DOI:10.1039/D1OB01500A - Nakamura E., Hata K., Takahata Y., Kurosaka H., Abe M., et al
Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix.
Commun. Biol. 2021:1258. DOI:10.1038/s42003-021-02793-9 - Barra, L., Awakawa, T., Shirai, K., Hu, Z., Bashiri, G., Abe, I.
β-NAD as a Building Block in Natural Product Biosynthesis.
Nature 2021;600:754-758. DOI:10.1038/s41586-021-04214-7 - 山中章弘
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生体の科学 2021;72(5):475-477. - 藤原和之、柿崎利和、姜玮茹、宮田茂雄、柳川右千夫
ノックアウトラットによる２種類のGABA合成酵素アイソフォームの機能的役割の解明.
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高脂肪食摂取加齢マウスにおける亜鉛の長期間過剰投与が学習・記憶能に及ぼす影響.
Trace Nutrients Research 2021;38:7-13. - 松本真司
上皮管腔形態形成の分子機構とその異常による腫瘍形成.
Journal of Japanese Biochemical Society 2021;93:733-748. DOI:10.14952/SEIKAGAKU.2021.930733 - 福田茉由, 向井淳
統合失調症の認知機能障害を改善するエピゲノム治療薬の開発.
精神科 2021;38(2):220-228. - 土田陸平, 住谷昌彦, 阿部博昭, 内田寛治
疼痛医学におけるPrecision Medicine（精密医療）-P2Y12受容体と痛み.
臨床麻酔 2021;45:137-145. - 冉慶松、周啓亮、小田佳奈子、泰江章博、阿部学、笹岡俊邦、崎村建司、味岡洋一、西條康夫
胚盤胞補完法とES細胞を用いた甲状腺再生.
日本再生医療学会総会(Web) 2021;20:ROMBUNNO.P-01-03. - 西條康夫、周啓亮、冉慶松、北原哲彦、小田佳奈子、泰江章博、笹岡俊邦、叶許緑、阿部学、崎村建司、土田正則、味岡洋一
胚盤胞補完法を用いた多能性幹細胞由来肺の作出.
日本呼吸器学会誌(Web) (Annals of the Japanese Respiratory Society (Web)) 増刊号 2021;10 - Kon, S. and Fujita, Y.
Cell competition-induced apical elimination of transformed cells, EDAC, orchestrates the cellular homeostasis.
Developmental Biology 2021;476:112-116. DOI:10.1016/j.ydbio.2021.03.015
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Anomalous atrium associated with persistent left superior vena cava.
Anatomical Science International. -:2021, 1-5. DOI:10.1007/s12565-021-00604-z - Asano T, Teh DBL, Yawo H.
Application of Optogenetics for Muscle Cells and Stem Cells.
Adv Exp Med Biol. 1293:2021, 359-375. DOI:10.1007/978-981-15-8763-4_23 - M. Sumiyoshi, Y. Kotani, Y. Ikuta, K. Suzue, M. Ozawa, T. Katakai, T. Yamada, T. Abe, K. Bando, S. Koyasu, Y. Kanaho, T. Watanabe and S. Matsuda
Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation.
The Journal of Immunology 206:2021, 366-375. DOI:10.4049/jimmunol.2000971 - Ishida A, Igarashi K, Ruike Y, Ishiwata K, Naito K, Kono S, Deguchi H, Fujimoto M, Shiga A, Suzuki S, Yoshida T, Tanaka T, Tatsuno I, Yokote K, Koide H.
Association of urinary free cortisol with bone formation in patients with mild autonomous cortisol secretion.
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Behavioral consequences of a combination of Gad1 haplodeficiency and adolescent exposure to NMDA receptor antagonist in Long-Evans rat.
Front Pharmacol. 12:2021, 646088. DOI:10.3389/fphar.2021.646088 - Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Maenaka K, Shimada T, Fukata M, Nishijo H, Takao K, Okabe S, Tabuchi K, Mishina M, Mori H, Fukai S.
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.
Nature Communications 12(1):2021, 1848. DOI:10.1038/s41467-021-22059-6 - Adhikara IM, Yagi K, Mayasari DS, Suzuki Y, Ikeda K, Ryanto GRT, Sasaki N, Rikitake Y, Nadanaka S, Kitagawa H, Miyata O, Igarashi M, Hirata K, Emoto N
Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
Arterioscler Thromb Vasc Biol 41(3):2021, 1076-1091. DOI:10.1161/ATVBAHA.120.315789 - Fumito Ishibashi, Tsutomu Fukuda, Shijiao Zha, Aya Hashirano, Shotaro Hirao, Masatomo Iwao
Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin.
Bioscience, Biotechnology, and Biochemistry 85:2021, 181-191. DOI:10.1093/bbb/zbaa028 - Sasaki T, Takei Y.
Constitutive increase of IL-17A in serum affects microglial activity in the hippocampal dentate gyrus.
Jap J Biol Psych. 32(2):2021, in press. - Shimizu T, Takahashi N, Huber VJ, Asawa Y, Ueda H, Yoshimori A, Muramatsu Y, Seimiya H, Kouji H, Nakamura H, Oguri H.
Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α.
Bioorg Med Chem. 30:2021, 115949. DOI:10.1016/j.bmc.2020.115949 - Doi H, Parajuli B, Horio T, Shigetomi E, Shinozaki Y, Noda T, Takahashi K, Hattori T, Koizumi S, Sawada K
Development of a label-free ATP image sensor for analyzing spatiotemporal patterns of ATP release from biological tissues.
Sensors and Actuators B: Chemical 335:2021, 129686. DOI:10.1016/j.snb.2021.129686 - Suzuki T, Ogita H, Sato A, Minamidate N, Hachiro K.
Differences between atherosclerotic and non-atherosclerotic patients in expression levels of inflammatory mediators in the adipose tissue around the coronary artery.
Int Heart J -:2021, in press. DOI:10.1536/ihj.20-585 - Katagiri T, Ushiki T, Nakajima-Takagi Y, Oshima M, Mikami T, Kawasaki A, Ishiguro H, Tanaka T, Sone H, Kitagawa H, Igarashi M, Iwama A, Masuko M
Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis.
Exp Hematol 96:2021, 52-62. DOI:10.1016/j.exphem.2021.02.003 - Tsutomu Fukuda, Seiya Okutani, Mayu Sumi, Kazuhito Miyagi, Gen Onodera, Masanari Kimura
Divergent Total Synthesis of Azalamellarins D and N.
Heterocycles 103:2021, in press. DOI:10.3987/COM-20-S(K)53 - Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K.
Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons.
Biomedicines 9 (1):2021, E49. DOI:10.3390/biomedicines9010049 - Ito, N., Riyadh, M., Ahmad, S., Hattori, S., Miyakawa, T. and Ohta, K. et al.
Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice.
Science Translational Medicine 13(587):2021, eaay7896. DOI:10.1126/scitranslmed.aay7896 - Sasaki T, Nagata R, Takahashi S, Takei Y
Effects of RORγt overexpression on the murine central nervous system.
Neuropsychopharmacology Reports -:2021, 1-9. DOI:10.1111/NPR2.12162 - Hikmawan Wahyu Sulistomo, Takayuki Nemoto, Yohko Kage, Hajime Fujii, Taku Uchida, Kogo Takamiya, Hideki Sumimoto, Hiroaki Kataoka, Haruhiko Bito, Ryu Takeya
Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.
Cerebral Cortex -:2021, in press. DOI:10.1093/cercor/bhaa355 - Fujihara K, Sato T, Miyasaka Y, Mashimo T, Yanagawa Y.
Genetic deletion of the 67-kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats.
FEBS Open Bio. -:2021, in press. DOI:10.1002/2211-5463.13065 - Sumitani M, Nishizawa D, Hozumi J, Ikeda K.
Genetic implications in quality palliative care and preventing opioid crisis in cancer-related pain management.
Journal of Neuroscience Research -:2021, in press. DOI:10.1002/jnr.24756 - Natsumeda M, Miyahara H, Yoshimura J, Okada M, Hirato J, Wataya T, Tateishi K, Rodriguez FJ, Suva ML, Taylor MD, Eberhart CG, Fujii Y, Kakita A
GLI3 is associated with neuronal differentiation in SHH-activated and WNT-activated medulloblastoma.
Journal of Neuropathology and Experimental Neurology 80(2):2021, 129-136. DOI:10.1093/jnen/nlaa141 - Miyata S, Kakizaki T, Fujihara K, Obinata H, Hirano T, Nakai J, Tanaka M, Itohara S, Watanabe M, Tanaka KF, Abe M, Sakimura K, Yanagawa Y.
Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice.
Mol Brain. 14:2021, 5. DOI:10.1186/s13041-020-00713-2 - Matsumoto K, Okamoto K, Okabe S, Fujii R, Ueda K, Ohashi K, Seimiya H.
G-quadruplex-forming nucleic acids interact with SF3B2 and suppress innate immune gene expression.
Genes Cells 26:2021, 65-82. DOI:10.1111/gtc.12824 - Dat NQ, Oikawa D, Yoishizato K, Tokunaga F, Pinzani M, Kawada M, et al.
His-Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
Hepatology. -:2021, in press. - Kumiko Naito,Sawako Suzuki,Chikako Ohwada,Jun-ichiro Ikeda,Tomoaki Tanaka,Koutaro Yokote.
ICAM1-Negative Intravascular Large B-Cell Lymphoma of the Pituitary Gland: A Case Report and Literature Review.
AACE Clinical Case Reports -:2021, in press. DOI:10.1016/j.aace.2021.01.011 - Aoki H, Abe C, Hara A, Miyazaki T, Morita H, Kunisada T.
Induced genetic ablation of Rest leads to the alteration of stimulus-induced response of the vagal nerve.
Genes Cells. 26(2):2021, 45-55. DOI:10.1111/gtc.12819 - Toshinori Matsuoka, Miwako Yamasaki, Manabu Abe, Yukiko Matsuda, Hiroyuki Morino, Hideshi Kawakami, Kenji Sakimura, Masahiko Watanabe, Kouichi Hashimoto
Kv11 (ether-à-go-go-related gene) voltage-dependent K+ channels promote resonance and oscillation of subthreshold membrane potentials.
Journal of Physiology (London) 599:2021, 547-569. DOI:10.1113/JP280342 - Nishiya N, Oku Y, Ishikawa C, Fukuda T, Dan S, Mashima T, Ushijima M, Matsuura M, Tomida A, Seimiya H, Yamori T, Iwao M, Uehara Y et al.
Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor.
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MEK inhibition preferentially suppresses anchorage‐independent growth in osteosarcoma cells and decreases tumors in vivo.
Journal of Orthopaedic Research -:2021, in press. DOI:10.1002/jor.25023 - Asada-Utsugi M, Uemura K, Noda Y, 他8名, Takahashi R, Hattori S, Miyakawa T, Ageta-Ishihara N, Kobayashi K, Kinoshita M, Kinoshita A.
Mice with a cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial memory tasks.
Molecular Brain 14(1):2021, 23. DOI:10.1186/s13041-021-00738-1 - Tesshu Hori, Shohei Ikuta, Satoko Hattori, Keizo Takao, Tsuyoshi Miyakawa, Chieko Koike
Mice with mutations in Trpm1, a gene within the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior.
Molecular Brain 14(1):2021, 61. DOI:10.1186/s13041-021-00749-y - Mushiake H, Ohshiro T, Osawa SI, Hosaka R, Katayama N, Tanaka T, Yawo H, Osanai M.
Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits.
Adv Exp Med Biol. 1293:2021, 501-509. DOI:10.1007/978-981-15-8763-4_34 - Arima Y, Nakagawa Y, Takeo T, Ishida T, Yamada T, Hino S, Yamagata K, Nakamura T, Nakagata N, Tsujita K
Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.
Nature Metabolism 3:2021, 196-210. DOI:10.1038/s42255-021-00342-6 - Aki Takahashi, Hossein Aleyasin, Tetsuya Sasaki, Sonoko Ogawa, Bruce S. McEwen and Scott J. Russo et al
Neuromodulatory effect of interleukin 1 in the dorsal raphe nucleus on individual differences in aggression.
Molecular Psychiatry -:2021, in press. - Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Matsumoto H, Miyakawa T, Nakada K.
Neuronal degeneration and cognitive impairment can be prevented via the normalization of mitochondrial dynamics.
Pharmacol Res. 163:2021, 105246. DOI:10.1016/j.phrs.2020.105246 - Tatsuya Yamahira, Gen Onodera, Tsutomu Fukuda, Masanari Kimura
Ni-catalyzed direct carboxylation of propargylic alcohols with carbon dioxide.
Chemistry Letters -:2021, in press. DOI:10.1246/cl.210008 - Ying Luo, Bun Chan, Tsutomu Fukuda, Gen Onodera, Masanari Kimura
Nickel-Catalyzed Carboxylation of Conjugated Dienes with Carbon Dioxide and DIBAL-H for the Synthesis of β,γ-Unsaturated Carboxylic Acids.
Synlett -:2021, in press. DOI:10.1055/a-1336-8034 - Mori T, Kido A, Kawahara I, Nukaga S, Miyagawa Y, Goto K, Mori S, Kishi S, Fujii K, Fujiwara-Tani R, Kuniyasu H
Nutritional intervention for cancer sarcopenia.
Ann Muscloskeletal Med 5(1):2021, 001-004. DOI:10.17352/amm.000024 - Akira C Saito, Tomohito Higashi, Yugo Fukazawa, Tetsuhisa Otani, Masashi Tauchi, Atsuko Y Higashi, Mikio Furuse, Hideki Chiba
Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function.
Molecular biology of the cell -:2021, in press. DOI:10.1091/mbc.E20-07-0464 - Ando S, Fukamachi K, Yoshimoto E, Matsumoto H, Iinuma M and Suzui M.
Palmitoyl piperidinopiperidine, a novel derivative of 10-hydroxy-2-decenoic acid, as a potent and selective anticancer agent against human colon carcinoma cell lines.
Int J Oncol 58:2021, 251-265. DOI:10.3892/ijo.2020.5160 - Okada M, Kawagoe Y, Sato Y, Nozumi M, Ishikawa Y, Tamada A, Yamazaki H, Sekino Y, Kanemura Y, Shinmyo Y, Kawasaki H, Kaneko N, Sawamoto K, Fujii Y, Igarashi M
Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates.
Mol Brain 14(1):2021, 66. DOI:10.1186/s13041-021-00755-0 - Hayashi T
Post-translational palmitoylation of ionotropic glutamate receptors in excitatory synaptic functions.
British Journal of Pharmacology 178:2021, 784-797. DOI:10.1111/bph.15050 - Shinozaki Y, Koizumi S
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A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity.
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A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities.
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Journal of Cell Science 133(18):2020, jcs251314. DOI:10.1242/jcs.251314 - Tetsuro Kawazoe, Hiroshi Saeki, Eiji Oki, Yoshinao Oda, Yoshihiko Maehara, Masaki Mori, Koji Taniguchi
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Brown adipocyte-derived miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes.
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Human Genetics 140(2):2020, 277-287. DOI:10.1007/s00439-020-02198-4 - Noriho Shinagawa, Kentaro Minami, Takayuki Ishida, Hiroshi Hijioka, Masatatsu Yamamoto, Kohichi Kawahara, Tatsuhiko Furukawa, Norifumi Nakamura
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Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue.
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Diabetes mellitus is associated with liver metastasis of colorectal cancer.
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Direct benzylation of amines with benzylic alcohols catalyzed by palladium/phosphine-borane catalyst system.
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Disruption of dystonin in Schwann cells results in late-onset neuropathy and sensory ataxia.
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Dynamic Axis-Tuned Cells in the Monkey Lateral Prefrontal Cortex during a Path-Planning Task.
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Editorial: The Earliest-Born Cortical Neurons as Multi-Tasking Pioneers: Expanding Roles for Subplate Neurons in Cerebral Cortex Organization and Function.
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Effect of proton pump inhibitors on colorectal cancer.
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Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities.
Bioscience, Biotechnology and Biochemistry 85(1):2020, 168-180. DOI:10.1093/bbb/zbaa024 - Saori Miwa, Ayako M. Watabe, Yohta Shimada, Takashi Higuchi, Hiroshi Kobayashi, Takahiro Fukuda, Fusao Kato, Hiroyuki Ida, Toya Ohashi
Efficient engraftment of genetically modified cells is necessary to ameliorate 1 central nervous system involvement of murine model of mucopolysaccharidosis type II by hematopoietic stem cell targeted gene therapy.
Molecular Genetics and Metabolism 130:2020, 262-273. DOI:10.1016/j.ymgme.2020.06.007 - Masami Ishido, Eiko Shimaya
Electromagnetic fields (EMF) facilitate cell migration and BrdU incorporation during an EMF-sensitive phase in a rat neurosphere assay in vitro.
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Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.
Cancer Sci. 111:2020, 3576-3587. DOI:10.1111/cas.14581 - Shinji Hirotsune, Hiroshi Kiyonari, Mingyue Jin, Kanako Kumamoto, Kayo Yoshida, Miki Shinohara, Hitomi Watanabe, Anthony Wynshaw-Boris, Fumio Matsuzaki
Enhanced homologous recombination by the modulation of targeting vector ends.
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Enhanced retrieval of taste associative memory by chemogenetic activation of locus coeruleus norepinephrine neurons.
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Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages.
Cell death discovery 6:2020, 1-14. DOI:10.1038/s41420-020-00300-3 - Miyagawa Y, Nukaga S, Mori T, Fujiwara-Tani R, Fujii K, Mori S, Goto K, Kishi S, Sasaki T, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H
Evaluation of cancer-derived myocardial impairments using a mouse model.
Oncotarget 11:2020, 3712-3722. DOI:10.18632/oncotarget.27759 - Amodio P., Shigeno, S. Ostojić L.
Evolution of Intelligence in cephalopods.
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Expression patterns of SLIT/ROBO mRNAs reveal a characteristic feature in the entorhinal-hippocampal area of macaque monkeys.
BMC Res Notes 262(13):2020, 1-6. DOI:10.1186/s13104-020-05100-7 - Yoshida K, Ito MA, Sato N, Obayashi K, Yamamoto K, Koizumi S, Tanaka S, Furuta K, Matsuoka I
Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation. .
J Immunol 204:2020, 3077-3085. DOI:10.4049/jimmunol.1900954 - Y. Isono, M. Furuya, T. Kuwahara, D. Sano, K. Suzuki, R. Jikuya, T. Mitome, S. Otake, M. Baba, LS Schmidt, WM Linehan, T. Kodama, M. Yao, N. Oridate, H. Hasumi
FLCN alteration drives metabolic reprogramming towards nucleotide synthesis and cyst formation in salivary gland.
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Fracture Risk Assessment Tool May Not Indicate Bone Fragility in Women With Type 2 Diabetes.
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Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16 high Cells In Vivo.
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Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.
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Genome-wide survey of ribosome collision.
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GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia.
Gastroenterology 158:2020, 1650-1666. DOI:10.1053/j.gastro.2020.01.046 - Alavi S, Ghadiri H, Dabirmanesh B, Moriyama K, Khajeh K, Masai H.
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Hereditary pancreatitis model by blastocyst complementation in mouse.
Oncotarget 11(22):2020, 2061-2073. DOI:10.18632/oncotarget.27595 - Nakayama J, Saito R, Hayashi Y, Kitada N, Tamaki S, Han Y, Semba K and Maki SA
High Sensitivity In Vivo Imaging of Cancer Metastasis Using a Near-Infrared Luciferin Analogue seMpai.
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Hippocampal 7α-hydroxylated neurosteroids are raised by training and bolster remote spatial memory with increase of the spine densities.
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HNF1a controls glucagon secretion in pancreatic a-cells through modulation of SGLT1.
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Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.
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Imaging of activity-dependent local translation in dendrite using photoconvertible protein.
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Neonatology -:2020, 1-8. DOI:10.1159/000511085 - Tetsuya Sasaki, Saki Tome, Yosuke Takei
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Molecular Brain 13(1):2020, 93. DOI:10.1186/s13041-020-00635-z - Takeuchi Y., Tatsuta S., Kito A., Fujikawa J., Itoh S., Itoh Y., Akiyama S., Yamashiro T., Wakisaka S., Abe M.
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Chem Sci 44:2020, 11998-12008. DOI:10.1039/D0SC04106H - Shogo Sasaki, Yue Ma, Takumi Ishizuka, Hong-Liang Bao, Takatsugu Hirokawa, Yan Xu, Masayuki Tera, Kazuo Nagasawa
Linear Consecutive Hexaoxazoles as G4 Ligands Inducing Chair-type Anti-parallel Topology of Telomeric G-Quadruplex.
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Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2.
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Malic enzyme 1 is associated with tumor budding in oral squamous cell carcinomas.
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Communications Biology 3(1):2020, 473. DOI:10.1038/s42003-020-01209-4 - Nobuyuki Sakayori, Kazuki Fujii, Keizo Takao, Kazuto Kobayashi, et al.
Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring's overeating in mice.
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Meiosis-specific C19orf57/4930432K21Rik/BRME1 modulates localization of RAD51 and DMC1 to DSBs in mouse meiotic recombination.
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PLOS Genetics 16(9):2020, e1009048. DOI:10.1371/journal.pgen.1009048 - Doki C, Nishida K, Saito S, Shiga M, Ogara H, Kuramoto A, Kuragano M, Nozumi M, Igarashi M, Nakagawa H, Kotani S, Tokuraku K.
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Mouse hair significantly lightened through replacement of the cysteine residue in the N-terminal domain of Mc1r using the CRISPR/Cas9 system.
Journal of Heredity 111(7):2020, 640-645. DOI:10.1093/jhered/esaa054 - Noritaka Yamaguchi
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Phosphorylation of the Anaphase Promoting Complex activator FZR1/ CDH1 is required for Meiosis II entry in mouse male germ cell.
Scientific Reports 10:2020, 10094. DOI:10.1038/s41598-020-67116-0 - Christian Hartmann, Ysabel Alessa Schwietzer, Tetsuhisa Otani, Mikio Furuse, Klaus Ebnet
Physiological functions of junctional adhesion molecules (JAMs) in tight junctions.
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Cancers 12:2020, 1-18. DOI:10.3390/cancers12071811 - Mito M, Mishima Y, and Iwasaki S
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MDPI Scholarly Community Encyclopedia-Topic Review 2020:2020, 1-3. - Taishi Kobayashi, Takuro Murakami, Yuu Hirose, and Toshihiko Eki
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Neuroscience Letters 743:2020, 135555. DOI:10.1016/j.neulet.2020.135555 - Fujiwara-Tani R, Fujii K, Mori S, Kishi S, Sasaki T, Ohmori H, Nakashima C, Kawahara I, NishiguchiY, Mori T, Sho M, Kondoh M, Luo Y, Kuniyasu H
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Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus.
Elife 9:2020, e59545. DOI:10.7554/eLife.59545 - Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H.
Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells.
Biomed Pharmacother. 128:2020, 110330-110340. DOI:10.1016/j.biopha.2020.110330 - Suzuki S, Minamidate T, Shiga A, Ruike Y, Ishiwata K, Naito K, Ishida A, Deguchi H, Fujimoto M, Koide H, Tatsuno I, Ikeda JI, Yamazaki Y, Sasano H, Yokote K.
Steroid metabolites for diagnosing and predicting clinicopathological features in cortisol-producing adrenocortical carcinoma.
BMC Endocr Disord. 20:2020, in press. DOI:10.1186/s12902-020-00652-y - Moe Matsushita, Takanori Nakamura, Hisashi Moriizumi, Hiroaki Miki, Mutsuhiro Takekawa
Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress.
Science Advances 6(26):2020, eaay9778. DOI:10.1126/sciadv.aay9778 - Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, and Noriyuki Sugo
Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons.
The Journal of Neuroscience 40(47):2020, 9012-9027. DOI:10.1523/JNEUROSCI.0319-20.2020 - Lin, Z, Nishikawa, H, Iguchi, Y, Iwanami, A, Kikuchi, M, Toda, S
Sustaining temporal attention prevents habit expression during operant learning in rats.
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Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/pi interaction.
Bioorganic & Medicinal Chemistry Letters 30:2020, 127657. DOI:10.1016/j.bmcl.2020.127657 - Yasuda M, Ma Y, Okabe S, Wakabayashi Y, Su D, Chang YT, Seimiya H, Tera M, Nagasawa K.
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Chem Commun 56:2020, 12905-12908. DOI:10.1039/d0cc04957c - Yamamoto, M., Ichinohe, T., Watanabe, A., Kobayashi, A., Zhang, R., Song, J., Kawaguchi, Y., Matsuda, Z. and Inoue, J.
The antimalarial compound atovaquone inhibits Zika and dengue virus infection by blocking E protein-mediated membrane fusion.
Viruses 12:2020, 1475. DOI:10.3390/v1212475 - Tadashi Nakagawa, Satoko Hattori, Tsuyoshi Miyakawa, Keiko Nakayama
The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression.
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The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation.
Nature Com. 11:2020, 2828. DOI:10.1038/s41467-020-16635-5 - Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, Yoshida K.
The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
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The pentatricopeptide repeat protein PGR3 is required for the translation of petL and ndhG by binding their 5'UTRs.
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Tight Junction Structure and Function Revisited.
Trends in Cell Biology 30(10):2020, 805-817. DOI:10.1016/j.tcb.2020.08.004 - Nakagawa S, Nguyen Pham KT, Shao X, and Doi M
Time-restricted G-protein signaling pathways via GPR176, Gz, and RGS16 set the pace of the master circadian clock in the suprachiasmatic nucleus.
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Translational landscape of protein-coding and non-protein-coding RNAs upon light exposure in Arabidopsis.
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Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway.
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Visually cued fear conditioning test for memory impairment related to cortical function.
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Anosmin-1 activates vascular endothelial growth factor receptor and its related signaling pathway for olfactory bulb angiogenesis.
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BRUP-1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson's disease model.
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Coordinated Changes in Cell Membrane and Cytoplasm During Maturation of Apoptotic Bleb.
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FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer.
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Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle.
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Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity.
Nature Commun. 10:2019, 2563. DOI:10.1038/s41467-019-10532-2 - Shotaro Yamano, Makoto Kimura, Yu Chen, Naoko Imamoto* and Rieko Ohki*.
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Nature Communications 10:2019, 2637. DOI:10.1038/s41467-019-10683-2 - Fujii T, Chiba Y, Nakayama-Imaohji H, Onishi S, Tanaka A, Katami H, Kaji T, Ieiri S, Miki T, Ueno M, Kuwahara T, Shimono R
Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.
J Pediatr Surg 54(12):2019, 2514-2519. DOI:10.1016/j.jpedsurg.2019.08.048 - Ishikawa Y, Okada M, Honda A, Ito Y, Tamada A, Endo N, *Igarashi M
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Mol Brain 12:2019, 93. DOI:10.1186/s13041-019-0510-z - Sanchez-Martin P, Komatsu M.
Physiological Stress Response by Selective Autophagy.
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Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation.
Journal of Neuroscience 39 (22):2019, 4208-4220. DOI:10.1523/JNEUROSCI.2468-18.2019 - Watanabe T, Suzuki H, Kano M
Postnatal Development of Cerebellar Neural Circuits.
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Prefrontal-Enriched SLIT1 Expression in Primate Cortex and its Alteration during Cortical Development.
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Rational engineering of XCaMPs, a multicolor GECI suite for in vivo imaging of complex brain circuit dynamics.
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Neuron 104:2019, 471-487. DOI:10.1016/j.neuron.2019.09.014 - Miyake T, and Doi M
Reconstitution of Organismal Liver Clock Function Requires Light.
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Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1.
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REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories. .
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Ruthenium-Catalyzed (Z)-Selective Hydroboration of Terminal Alkynes with Naphthalene-1,8-diaminatoborane.
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Front Cell Neurosci, section Cellular Neuropathology 13:2019, 344-350. DOI:10.3389/fncel.2019.00344 - Toshio Fujino and Tetsuya Mitsudomi
Sensitivity and Resistance of MET Exon 14 Mutations in Lung Cancer to Eight MET Tyrosine Kinase Inhibitors In Vitro.
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SIRT7 regulates the nuclear export of NF-kB p65 by deacetylating Ran.
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Stress augments the rewarding memory of cocaine via the activation of brainstem-reward circuitry.
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Suzuki-Miyaura Cross-Coupling of 1,8-Diaminonaphthalene (dan)-Protected Arylboronic Acids.
ACS CATAL 10:2019, 352-357. DOI:10.1021/acscatal.9b03667 - Chi-Wai Fung, Go Fukada, Yuichiro Mutoh, Noriko Tsuchida, Shinchi Saito
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Synthesis of Helical 3,3′-Bridged-2,2′-bibenzo[g]quinolines.
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Targeting claudin-4 enhances chemosensitivity of pancreatic ductal carcinomas.
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The effect of MR1 ligand glycol-analogues on mucosal-associated invariant T (MAIT) cell activation.
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The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells.
Cancer Res 80:2019, 471-483. DOI:10.1158/0008-5472.CAN-19-1196 - Ahmat Amin MKB, Shimizu A, Ogita H.
The pivotal roles of the epithelial membrane protein family in cancer invasiveness and metastasis.
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Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter.
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Whole-brain Block-Face Serial Microscopy Tomography at Subcellular Resolution Using FAST.
Nat Protoc 14 (5):2019, 1509-1529. DOI:10.1038/s41596-019-0148-4 - Sadaiwa Yorimoto, Akira Tsubouchi, Haruki Mizoguchi, Hideaki Oikawa, Yoshiaki Tsunekawa, Tomoya Ichino, Satoshi Maeda and Hiroki Oguri
Zn(OTf)2-mediated annulations of N-propargylated tetrahydrocarbolines: divergent synthesis of four distinct alkaloidal scaffolds.
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A method of producing genetically manipulated mouse mammary gland.
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A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway.
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Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP.
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ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus.
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Analysis of Neuro-Neuronal Synapses Using Embryonic Chick Ciliary Ganglion via Single-Axon Tracing, Electrophysiology, and Optogenetic Techniques.
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Analysis of the neuronal network of the medullary respiratory center in transgenic rats expressing archaerhodopsin-3 in Phox2b-expressing cells.
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Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway.
Cell Death Dis. 10(2):535-540, 2019. DOI:10.1038/s41419-019-1356-0 - Saito T., Komatsu M. (19人中19番目)
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Calvarial Bone Implantation and in vivo Imaging of Tumor Cells in Mice.
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Chemically modified antisense oligonucleotide against ARL4C inhibits primary and metastatic liver tumor growth.
Mol. Cancer Ther. 18:602-612, 2019. DOI:10.1158/1535-7163.MCT-18-082 - Orimo, T., I. Sasaki, H. Hemmi, T. Ozasa, Y. Fukuda-Ohta, T. Ohta, M. Morinaka, M. Kitauchi, T. Yamaguchi, Y. Sato, T. Tanaka, K. Hoshino, K. I. Katayama, S. Fukuda, K. Miyake, M. Yamamoto, T. Satoh, K. Furukawa, E. Kuroda, K. J. Ishii, K. Takeda, and T. Kaisho.
Cholera toxin B induces interleukine-1β production from resident peritoneal macrophages through pyrin as well as NLRP3 inflammasome.
Int Immunol. :in press, 2019. DOI:10.1093/intimm/dxz004 - Adhikara IM, *Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata K, Emoto N
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.
Biochem Biophys res Commun 509:89-95, 2019. DOI:10.1016/j.bbrc.2018.12.068 - Kimura H, Yamamoto H, Harada T, Fumoto K, Osugi Y, Sada R, Maehara N, Hikita H, Mori S, Eguchi H, Ikawa M, Takehara T, Kikuchi A.
CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy.
Clin Cancer Res. 25:1936-1947, 2019. DOI:10.1158/1078-0432.CCR-18-2124 - Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.
CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.
Oncogene 14:2580-2594, 2019. DOI:10.1038/s41388-018-0603-7 - Bando Y*, Sakamoto M* (Co-first and corresponding author), Kim S, Ayzenshtat I, Yuste R.
Comparative evaluation of genetically encoded voltage indicators.
Cell Reports 26(3):802-813, 2019. DOI:10.1016/j.celrep.2018.12.088 - Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy.
Pathobiology 86:182-189, 2019. DOI:10.1159/000496027 - Furusho, K., T. Shibata, R. Sato, R. Fukui, Y. Motoi, Y. Zhang, S. I. Saitoh, T. Ichinohe, M. Moriyama, S. Nakamura, and K. Miyake.
Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.
Int Immunol. 31:167-173, 2019. DOI:10.1093/intimm/dxy075 - Naniwa K., Sugimoto Y., Osuka K. and Aonuma H.
Defecation initiates walking in the cricket Gryllus bimaculatus.
J. Insect Physiol. 112:117-122, 2019. DOI:10.1016/j.jinsphys.2018.11.004 - Sashida G, Oshima M, Iwama A.
Deregulated Polycomb functions in myeloproliferative neoplasms.
Int J Hematol 110(2):170-178, 2019. DOI:10.1007/s12185-019-02600-6 - Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.
Oncogene 38:635-655, 2019. DOI:10.1038/s41388-018-0481-z - Serita, T., Miyahara, M., Tanimizu, T., Takahashi, S., Oishi, S., Nagayoshi, T., Tsuji, R., Inoue, H., Uehara, M., Kida, S*.
Dietary magnesium deficiency impairs hippocampus-dependent memories without changes in the spine density and morphology of hippocampal neurons in mice.
Brain Res Bull. 144:149-157, 2019. DOI:10.1016/j.brainresbull.2018.11.019 - Yoshitomi S, Takahashi Y, Imai K, Koshimizu E, Miyatake S, Nakashima M, Saitsu H, Matsumoto N, Kato M, Fujita T, Ishii A, Hirose S, Inoue Y.
Different types of suppression-burst patterns in patients with epilepsy of infancy with migrating focal seizures (EIMFS).
Seizure 65:118-123, 2019. DOI:10.1016/j.seizure.2019.01.009 - Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Mizutani A, et al.
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
Journal of Medicinal Chemistry 62(7):3407-3427, 2019. DOI:10.1021/acs.jmedchem.8b01888 - Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI.
Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
J. Exp. Med. 216:950-965, 2019. DOI:10.1084/jem.20180900 - Takanori NOZAWA, Masayasu OKADA, Manabu NATSUMEDA, Takeyoshi EDA, Hideaki ABE, Yoshihiro TSUKAMOTO, Kouichirou OKAMOTO, Makoto OISHI, Hitoshi TAKAHASHI, Yukihiko FUJII, and Akiyoshi KAKITA
EGFRvIII is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma.
Neurologia medico-chirurgica (Tokyo) 59(3):89-97, 2019. DOI:10.2176/nmc.oa.2018-0078 - Tome S, Sasaki T, Takahashi S, Takei Y.
Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic-polycytidylic acid in inducing fetal loss.
Experimental Animals Volume 68 Issue 4:491-497, 2019. DOI:10.1538/expanim.19-0038 - Noritake A, Nakamura K.
Encoding prediction signals during appetitive and aversive Pavlovian conditioning in the primate lateral hypothalamus.
Journal of neurophysiology 121(2):396-417, 2019. DOI:10.1152/jn.00247.2018 - Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N
Forkhead box protein A1 confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.
J Cell Biochem. 120:2259-2270, 2019. DOI:10.1002/jcb.27551 - Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H.
Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo.
J Physiol Sci. 69(1):65-77, 2019. DOI:10.1007/s12576-018-0618-4 - Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K.
Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.
Addict Biol 25(1):e12723, 2019. DOI:10.1111/adb.12723 - Jun Watanabe, Manabu Natsumeda, Masayasu Okada, Daiki Kobayashi, Yu Kanemaru, Yoshihiro Tsukamoto, Makoto Oishi, Akiyoshi Kakita, Yukihiko Fujii
High detection rate of MYD88 mutations in cerebrospinal fluid from patients with central nervous system lymphomas.
JCO Precision Oncology :in press, 2019. - Kamil M, Shinsato Y, Higa N, Hirano T, Idogawa M, Takajo T, Minami K, Shimokawa M, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K.
High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme.
British Journal of Cancer 120(8):819-826, 2019. DOI:10.1038/s41416-019-0413-x - Htun Y, Nakamura S, Nakao Koyano K, Ohta K, Morimoto A, Wakabayashi T, Sugino M, Fujioka K, Kato I, Kondo S, Yasuda S, Miki T, Ueno M, Kusaka T
Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.
Scientific Reports 9:4088, 2019. DOI:10.1038/s41598-019-40674-8 - Umehara T, Mori R, Mace K, Murase T, Abe Y, Yamamoto T, Ikematsu K
Identification of specific microRNAs in neutrophils of type 2 diabetic mice: overexpression of microRNA-129-2-3p accelerates diabetic wound healing.
Diabetes 68(3):617-630, 2019. DOI:10.1124/jpet.118.253922 - Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
Neuroscience Resarch 139:63-68, 2019. DOI:10.1016/j.neures.2018.08.016 - Yosuke Takei, Saki Tome, Tetsuya Sasaki
Intracellular transport of NMDA receptors and Schizophrenia.
Japanese Journal of Biological Psychiatry :in press, 2019. - *Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, R?os A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y
Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.
The Journal of Neuroscience 39(3):485-502, 2019. DOI:10.1523/JNEUROSCI.1584-18.2018 - Toyokuni S
Iron Addiction with Ferroptosis-resistance in Asbestos-induced Mesothelial Carcinogenesis: Toward the Era of Mesothelioma Prevention.
Free Radical Biology & Medicine 133:206-215, 2019. DOI:10.1016/j.freeradbiomed.2018.10.401 - Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.
Cerebral Cortex 29(9):3738-3751, 2019. DOI:10.1093/cercor/bhy253 - Tsutomu Fukuda, Yusuke Nanjo, Masahiro Fujimoto, Kenyu Yoshida, Yuko Natsui, Fumito Ishibashi, Fumiyasu Okazaki, Hideto To, Masatomo Iwao
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
Bioorganic and Medicinal Chemistry 27 (2):265－277, 2019. DOI:10.1016/j.bmc.2018.11.037 - Miyazaki T, Chowdhury S, Yamashita T, Matsubara T, Yawo H, Yuasa H, Yamanaka A.
Large Timescale Interrogation of Neuronal Function by Fiberless Optogenetics Using Lanthanide Micro-particles. 26(4):1033-1043.e5.
Cell Rep. 26(4):1033-1043.e5., 2019. DOI:10.1016/j.celrep.2019.01.001 - N Shiina
Liquid- and solid-like RNA granules form through specific scaffold proteins and combine into biphasic granules.
J. Biol. Chem. 294:107149 - 107149, 2019. DOI:10.1074/jbc.RA118.005423 - M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T,Oike Y.
Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice.
Circ J. 2019 Jan 25;83(2):368-378, 2019. DOI:10.1253/circj.CJ-18-0925 - Kawahara I, Goto K, Kodama K, Luo Y, Fujiwara-Tani R, Mori T, Miyagawa Y, Tanaka H, Kodama H, Hirayama A, Hosoito N, Taniguchi Y, Miki Y, Kuniyasu H
Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle.
Pathobiology 86:254-262, 2019. DOI:10.1159/000501524 - Iwatani Y, Ogawa, H, Shidara H, Sakura M, Sato T, Hojo MK, Honma A, Tsurui K
Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals.
Advanced Robotics :in press, 2019. - Ueno T, Kaomatsu M
Measuring Nonselective and Selective Autophagy in the Liver.
Methods Mol Biol. 1880, 2019. DOI:10.1007/978-1-4939-8873-0_34 - Keisuke Iida, Yamato Tsushima, Yue Ma, Shadi Sedghi Masoud, Mai Sakuma, Tomomi Yokoyama, Wataru Yoshida, Kazunari Ikebukuro, Kazuo Nagasawa
Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole.
Bioorg. Med. Chem. 27:1742-1746, 2019. DOI:10.1016/j.bmc.2019.02.056 - Sakayori N, Kato S, Sugawara M, Setogawa S, Fukushima H, Ishikawa R, Kida S, Kobayashi K.
Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus.
Mol Brain 12:13, 2019. DOI:10.1186/s13041-019-0431-x - Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H.
mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model.
Pharmacol Biochem Behav.? 176:1-5, 2019. DOI:10.1016/j.pbb.2018.11.003 - Park S, Nayantai E, Komatsu T, Hayashi H, Mori R, Shimokawa I
NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning.
J Gerontol A Biol Sci Med Sci. :in press, 2019. DOI:10.1093/gerona/gly282 - Hosoda, H., *Kida, S
NSP-C contributes to the upregulation of CLOCK/BMAL1-mediated transcription.
Cytotechnology 71:453-460, 2019. DOI:10.1007/s10616-018-0266-9 - Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Yamanaka A, Hikida T, Manabe H, Yamaguchi M.
Opposing roles of dopamine receptor D1- and D2-expressing neurons in the anteromedial olfactory tubercle in acquisition of place preference in mice.
Front Behav Neurosci 13:50, 2019. DOI:10.3389/fnbeh.2019.00050 - Liu Y, Ohshiro T, Sakuragi S, Koizumi K, Mushiake H, Ishizuka T, Yawo H.
Optogenetic study of the response interaction among multi-afferent inputs in the barrel cortex of rats.
Sci Rep. 9(1):3917, 2019. DOI:10.1038/s41598-019-40688-2 - Ghandour K#,?Ohkawa N#,＊, Fung CCA#, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, Nishizono H, Matsuo M, Osanai M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Kitamura T, Fukai T, Inokuchi K＊?(#Equally contributed,?＊Corresponding authors)
Orchestrated ensemble activities constitute a hippocampal memory engram.
Nature Communications 10(1):2637, 2019. DOI:10.1038/s41467-019-10683-2 - Nagase, M., Mikami, K., and Watabe, A.M.# (#責任著者)
Parabrachial-to-amygdala control of aversive learning.
Current Opinion in Behavioral Sciences :in press, 2019. - Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T
Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation deficient mice.
Neuropsychopharmacology Reports 39:61-66, 2019. DOI:10.1002/npr2.12044 - Okada, K., Araki, M., Sakashita, T., Ma, B., Kanda, R., Yanagitani, N., Horiike, A., Koike, S., Oh-Hara, T., Watanabe, K., Tamai, K., Maemondo, M., Nishio, M., Ishikawa, T., Okuno, Y., Fujita, N. and *Katayama, R.
Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance.
EBioMedicine 41:105-119, 2019. DOI:10.1016/j.ebiom.2019.01.019 - Tetsuya Sasaki (Corresponding Author), Yusuke Komatsu, Tetsuo Yamamori (Corresponding Author)
Prefrontal-Enriched SLIT1 Expression in Primate Cortex and its Alteration during Cortical Development.
Japanese Journal of Biological Psychiatry 30(2):in press, 2019. - Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning.
Neurochem Int 126:11-18, 2019. DOI:10.1016/j.neuint.2019.02.011 - Shimizu H., Takeishi S., Nakatsumi H., Nakayama KI.
Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells.
JCI Insight 4:pii-125138, 2019. DOI:10.1172/jci.insight.125138 - Yoshitomi S, Takahashi Y, Yamaguchi T, Oboshi T, Horino A, Ikeda H, Imai K, Okanishi T, Nakashima M, Saitsu H, Matsumoto N, Yoshimoto J, Fujita T, Ishii A, Hirose S, Inoue Y.
Quinidine therapy and therapeutic drug monitoring in four patients with KCNT1 mutations.
Epileptic Disorders 21(1):48-54, 2019. DOI:10.1684/epd.2019.1026 - Koso H, Tsuhako A, Matsubara D, Fujita Y, Watanabe S.
Ras activation in retinal progenitor cells induces tumor formation in the eye.
Exp. Eye Res. 180:39-42, 2019. DOI:10.1016/j.exer.2018.11.025 - Ikuma Kato, Mitsuko Furuya, Masaya Baba, Yoichi Kameda, Masanori Yasuda, Koshiro Nishimoto, Masafumi Oyama, Toshinari Yamasaki, Osamu Ogawa, Hitoshi Niino, Noboru Nakaigawa, Yuta Yano, Kazumasa Sakamoto, Yoji Urata, Kazuya Mikami, Shigetaka Yamasaki, Reiko Tanaka, Toshio Takagi, Tsunenori Kondo, Yoji Nagashima
RBM10‐TFE3 Renal Cell Carcinoma Characterized by Paracentric Inversion with Consistent Closely Split Signals in Break‐apart Fluorescence in situ Hybridization: Study of Ten Cases and a Literature Review.
Histopathology 75(2):254-265, 2019. DOI:10.1111/his.13866 - Imanishi, T., M. Unno, W. Kobayashi, N. Yoneda, S. Matsuda, K. Ikeda, T. Hoshii, A. Hirao, K. Miyake, G. N. Barber, M. Arita, K. J. Ishii, S. Akira, and T. Saito.
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.
Life Sci Alliance 2(1):e201800282, 2019. DOI:10.26508/lsa.201800282 - Kida, S
Reconsolidation/Destabilization, Extinction and Forgetting of Fear Memory as Therapeutic Targets for PTSD.
Psychopharmacology 236:49-57, 2019. DOI:10.1007/s00213-018-5086-2 - Ishifune, C., Tsukumo, SI., Maekawa Y., Hozumi, K., Chung, DH., Motozono, C., Yamasaki, S., Nakano, H., Yasutomo, K.
Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.
PLoS Biol. 17:e3000262, 2019. DOI:10.1371/journal.pbio.3000262 - Hara S, Fukumura S, Ichinose H
Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity.
J Biol Chem 294:1420-1427, 2019. DOI:10.1074/jbc.RA118.005280 - Nakajo H, Ishibashi K, Aoyama K, Kubota S, Hasegawa H, Yamaguchi N, Yamaguchi N
Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling.
Biochem Biophys Res Commun. 511:765-771, 2019. DOI:10.1016/j.bbrc.2019.02.130 - Sugiyama S., Yumimoto K., Inoue I., Nakayama KI.
SCF(Fbxw7) ubiquitylates KLF7 for degradation in a manner dependent on GSK-3?mediated phosphorylation.
Genes Cells 24:354-365, 2019. DOI:10.1111/gtc.12680 - Tatsukawa T, Raveau M, Ogiwara I, Hattori S, Miyamoto H, Mazaki E, Itohara S, Miyakawa T,Montal M, Yamakawa K*
Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity.
Mol Autism 10:15, 2019. DOI:10.1186/s13229-019-0265-5 - Gong B., Kiyotani K., Sakata S., Nagano S., Kumehara S., Baba S., Besse B., Yanagitani N., Friboulet L., Nishio M., Takeuchi K., Kawamoto H., Fujita N., *Katayama R.
Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer.
J Exp Med. 216(4):982-1000, 2019. DOI:10.1084/jem.20180870 - Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F.
Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling.
Biochemical and Biophysical Research Communications 509(3):700-706, 2019. DOI:10.1016/j.bbrc.2018.12.164 - Mitsuhiro Wada, Hiroyuki Suzuki, Mitsuyasu Kato, Hideaki Oikawa, Akira Tsubouchi, Hiroki Oguri
Stereo-Divergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Anti-proliferative Activity.
ChemBioChem 20(10):1273-1281, 2019. DOI:10.1002/cbic.201800815 - Yu Buchin, Yuka Sakemi, Ruriko Hamashima, Yuko Morioka, Daisuke Yamanaka,
Fumihiko Hakuno, Shin-ichiro Takahashi, Kazutoshi Shindo
Structures and biological activities of new carnosic acid- and carnosolrelated compounds generated by heat treatment of rosemary.
Phytochemistry Letters 30:43-48, 2019. DOI:10.1016/j.phytol.2019.01.005 - Tsutomu Fukuda, Yuri Matsuo, Fuyuki Matsuoka, Naoki Yoshioka, Gen Onodera, Masanari Kimura, Fumito Ishibashi, Masatomo Iwao
Synthesis and evaluation of topoisomerase I inhibitors possessing the 5,13-dihydro-6H-benzo[6,7]indolo[3,2-c]quinolin-6-one scaffold.
Heterocycles 99:1032-1052, 2019. DOI:10.3987/COM-18-S(F)70 - Yue Ma, Keisuke Iida, Shogo Sasaki, Takatsugu Hirokawa, Heddi Brahim, Anh Tuan Phan, Kazuo Nagasawa
Synthesis and telomeric G-quadruplex-stabilizing ability of macrocyclic hexaoxazoles bearing three side chains.
Molecules 24:263, 2019. DOI:10.3390/molecules24020263 - Ashida, Y., Yanagita, R. C., Kawanami, Y., Okamura, M., Dan, S. and?Irie, K.
Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin.
Heterocycles 99(2):942-957, 2019. DOI:10.3987/COM-18-S(F)60 - Nishiguchi Y, Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Kishi S, Mori S, Goto K, Yasui W, Sho M*, Kuniyasu H
Targeting claudin-4 enhances CDDP-chemosensitivity of gastric cancer.
Oncotarget 10:2189-2202, 2019. DOI:10.18632/oncotarget.26758 - Mito M.,Kadota M., Nakagawa S.*, Iwasaki S.*
tChIP-Seq: cell-type-specific Eepigenome profiling.
J. Vis. Exp 143:e58298, 2019. DOI:10.3791/58298 - Masaya Baba, Mitsuko Furuya, Takanobu Motoshima, Martin Lang, Shintaro Funasaki, Wenjuan Ma, Hong-Wei Sun, Hisashi Hasumi, Ying Huang, Ikuma Kato, Tsuyoshi Kadomatsu, Yorifumi Satou, Nicole Morris, Baktiar O. Karim, Lilia Ileva, Joseph D. Kalen, Luh Ade Wilan Krisna, Kimi Araki et al.
TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease.
Molecular Cancer Research 17:1613-1626, 2019. DOI:10.1158/1541-7786.MCR-18-1235 - Iwasaki S.*, Iwasaki W., Takahashi M., Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T.*, and Ingolia NT.*
The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA.
Mol. Cell 73:1-10, 2019. DOI:10.1016/j.molcel.2018.11.026 - Liang L, Teh D, Dinh ND, Chen W, Chen Q, Wu Y, Chowdhury S, Yamanaka A, Sum TC, Chen CH, Thakor N, All A, Liu X
Upconversion Amplification through Dielectric Superlensing Modulation.
Nat Commun 10:1391, 2019. DOI:10.1038/s41467-019-09345-0 - 平石哲也、棗田学、岡田正康、大石誠、藤井幸彦
悪性髄膜腫における個別化医療の可能性.
Precision Medicine 2(1):54-58, 2019. - Ito N., Mohammad B., A., Shah A., I., A., and Ohta K.
Transdifferentiation of human somatic cells by ribosome.
Development Growth & Differentiation 60:241-247, 2018. DOI:10.1111/dgd.12538 - 山本一男
"サイズ"で斬る生物学への誘い.
実験医学 36(13):2168-2173, 2018. - Mizotani Y, Suzuki M, Hotta K, Watanabe H, Shiba K, Inaba K, Tashiro E, Oka K and Imoto M.
14-3-3εa directs the pulsatile transport of basal factors towards the apical domain for lumen growth in tubulogenesis.
Proc. Natl. Acad. Sci. USA 115:E8873-E8881, 2018. DOI:10.1073/pnas.1808756115 - Gong, B., Oh-Hara, T., Fujita, N. and *Katayama, R.
3D culture system containing gellan gum restores oncogene dependence in ROS1 rearrangements non-small cell lung cancer.
Biochem. Biophys. Res. Commun., 501:527-533, 2018. DOI:10.1016/j.bbrc.2018.05.031 - Horai T, Hishimoto A, Otsuka I, So T, Mouri K, Shimmyo N, Boku S, Okishio N, Sora I.
A Cross-Sectional Study Exploring Useful Indicators for Low Bone Mineral Density in Male Alcoholic Patients.
Neuropsychiatr Dis Treat 14:663-669, 2018. DOI:10.2147/NDT.S153360 - Kosuke Ishikawa, Yuta Kobayashi, Yutaro wakabayashi, Shinya Watanabe and Kentaro Semba
A highly sensitive trap vector system for isolating reporter cells and identification of responsive genes.
Biology Methods and Protocols 3:bpy003, 2018. DOI:10.1093/biomethods/bpy003 - Nakajima C, Kamimoto K, Miyajima K, Matsumoto M, Okazaki Y, Kobayashi-Hattori K, Shimizu M, Yamane T, Oishi Y, Iwatsuki K.
A new method for identifying mouse pancreatic ducts.
Tissue Eng. ?24(8):480?485, 2018. DOI:10.1089/ten.tec.2018.0127 - Kamijo Y, Kawahara K, Yoshinaga T, Kurata H, Arima K, Furukawa T.
A novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analyses.
Oncoscience. 5:88-98, 2018. DOI:10.18632/oncoscience.411 - Okumura A, Maruyama K, Shibata M, Kurahashi H, Ishii A, Numoto S, Hirose S, Kawai T, Iso M, Kataoka S, Okuno Y, Muramatsu H, Kojima S.
A patient with a GNAO1 mutation with decreased spontaneous movements, hypotonia, and dystonic features.
Brain & Development 40(10):926-930, 2018. DOI:10.1016/j.braindev.2018.06.005 - Zhang Y, Nakano D, Guan Y, Hitomi H, Masaki T, Kobara H, Sugaya Y, Nishiyama A.
A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice.
Kidney Int. 94(3):524-535., 2018. DOI:10.1016/j.kint.2018.05.002 - Yabe R, Tsuji S, Mochida S, Ikehara T, Usui T, Ohama T*, Sato K
A stable association with PME‐1 may be dispensable for PP2A demethylation ? implications for the detection of PP2A methylation and immunoprecipitation.
FEBS Open Bio 8(9):1486-1496, 2018. DOI:10.1002/2211-5463.12485 - Toratani, M., Konno, M., Asai, A., Koseki, J., Kawamoto, K., Tamari, K., Li, Z., Sakai, D., Kudo, T., Satoh, T., Sato, K., Motooka, D., Okuzaki, D., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
Ability of a convolutional neural network to differentiate between mouse and human cell lines and their radioresistant clones using microscopic images.
Cancer Res 78, 2018. DOI:10.1158/0008-5472 - Takahashi Y, Hamasaki M, Aoki M, Koga K, Koshikawa N, Miyamoto S, Nabeshima K.
Activated EphA2 processing by MT1-MMP is involved in malignant transformation of ovarian tumours in vivo.
Anticancer Res 38:4257-4266, 2018. DOI:10.21873/anticanres.12722 - Ichimura Y, Komatsu M.
Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.
Front Oncol. 8, 2018. DOI:10.3389/fonc.2018.00210 - Moriya S, Yamashita A, Kawashima S, Nishi R, Yamanaka A, Kuwaki T.
Acute aversive stimuli rapidly increase the activity of ventral tegmental area dopamine neurons in awake mice.
Neuroscience 386:16-23, 2018. DOI:10.1016/j.neuroscience.2018.06.027 - Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, Endo M, Zhu S, Fan H, Horiguchi H, Morinaga J, Terada K, Yoshizawa T, Yamagata K, Oike Y
Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice.
J Biol Chem 293:1596-1609, 2018. DOI:10.1074/jbc.M117.814996 - Ichinose H, Inoue KI, Arakawa S, Watanabe Y, Kurosaki H, Koshiba S, Hustad E, Takada M, Aasly JO
Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease.
J Neural Transm 125:45-52, 2018. DOI:10.1007/s00702-017-1784-x - Tsurumaru, H., Ito, N., Mori, K., Wakai, S., Uchiyama, T., Iino, T., Hosoyama, A., Ataku, H., Nishijima, K., Mise, M., Shimizu, A., Harada, T., Horikawa, H., Ichikawa, N., Sekigawa, T., Jinno, K., Tanikawa, S., Yamazaki, J., Sasaki, K., Yamazaki, S., Fujita, N., and Harayama, S.,
An extracellular [NiFe] hydrogenase mediating iron corrosion is encoded in a genetically unstable genomic island in Methanococcus maripaludis.
Scientific Reports 8 8:15149, 2018. DOI:10.1038/s41598-018-33541-5 - M. Ishido*
An Overview of Development of Quantitative Neurotoxicity Testing In vitro.
J. Applied Life Sci. Intl. 19:2394-1103, 2018. DOI:10.9734/JALSI/2018/45377 - Fink J, Jackney A, Matsumoto M, Maekawa T, Nakazato K, Horie S.
Anabolic-androgenic steroids: procurement and administration practices of doping athletes.
Physician. Sportsmedicine 2 47(1):10-14., 2018. DOI:10.1080/00913847.2018.1526626 - Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrian Marchand, Fernaldo Richtia Winnerdy, Valerie Gabelica, Anh Tuan Phan, Masato Katahira & Kazuo Nagasawa
Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound.
ChemBioChem 19:2268-2272, 2018. DOI:10.1002/cbic.201800425 - Shimizu Y, Tamada S, Kato M, Hirayama Y, Takeyama Y, Iguchi T, Sadar MD, Nakatani T.
Androgen Receptor Splice Variant 7 Drives the Growth of Castration Resistant Prostate Cancer without Being Involved in the Efficacy of Taxane Chemotherapy.
J Clin Med 7(11):E444, 2018. DOI:10.3390/jcm7110444 - Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Nishiguchi Y, Kishi S, Mori S, Goto K, Kondoh M, Kuniyasu H
Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer.
Oncotarget 9(100):37367-37378, 2018. DOI:10.18632/oncotarget.26427 - Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki E, Takeda A, Le HPN, Hayashi H, Hiasa M, Moriyama Y, Ikenaka K, Tanaka KF, Koizumi S
Anti-Depressant Fluoxetine Reveals its Thrapeutic Effect Via Astrocytes.
E BioMedicine 32:72-83, 2018. DOI:10.1016/j.ebiom.2018.05.036 - Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, R?os A, Kawabata M, Kimura M, Sakai Y, *Isomura Y
Area-specific modulation of functional cortical activity during block-based and trial-based proactive inhibition.
Neuroscience 388:297-316, 2018. DOI:10.1016/j.neuroscience.2018.07.039 - Saika M, Inoue D, Nagase R, Sato N, Tsuchiya A, Yabushita T, Kitamura T, Goyama S.
ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFb pathway genes through histone deacetylation.
Sci. Rep. 8(1):15873, 2018. DOI:10.1038/s41598-018-33881-2 - Hisashi Hasumi, Mitsuko Furuya, Kenji Tatsuno, Shogo Yamamoto, Masaya Baba, Yukiko Hasumi, Yasuhiro Isono, Kae Suzuki, Ryosuke Jikuya, Shinji Otake, Kentaro Muraoka, Kimito Osaka, Narihiko Hayashi, Kazuhide Makiyama, Yasuhide Miyoshi, Keiichi Kondo, Noboru Nakaigawa, Takashi Kawahara, Koji Izumi, Junichi Teranishi, Yasushi Yumura, Hiroji Uemura, Yoji Nagashima, Adam R Metwalli, Laura S Schmidt, Hiroyuki Aburatani, W Marston Linehan, Masahiro Yao
BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes.
Human molecular genetics 27(15):2712-2724, 2018. DOI:10.1093/hmg/ddy181 - Michael S Nahorski, Sateesh Maddirevula, Ryosuke Ishimura, Saud Alsahli, Angela Brady, Ana?s Begemann, Tsunehiro Mizushima, Francisco J. Guzm?n-Vega, Miki Obata, Yoshinobu Ichimura, Hessa S Alsaif, Shams Anazi, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Dorota Monies, Mohamed Abouelhoda, Brian F Meyer, Majid Alfadhel, Wafa Eyaid, Markus Zweier Katharina Steindl, Anita Rauch, Stefan T. Arold, *C Geoffrey Woods, *Masaaki Komatsu, *Fowzan S Alkuraya.
Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.
Brain 141:1934-1945, 2018. DOI:10.1093/brain/awy135 - Mutoh, H., M. Kato, T. Akita, T. Shibata, H. Wakamoto, H. Ikeda, H. Kitaura, K. Aoto, M. Nakashima, T. Wang, C. Ohba, S. Miyatake, N. Miyake, A. Kakita, K. Miyake, A. Fukuda, N. Matsumoto, and H. Saitsu.?
Biallelic Variants in CNPY3, Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy.
Am J Hum Genet 102(2):321-329, 2018. DOI:10.1016/j.ajhg.2018.01.004 - Kondo T, Saito R, Otaka M, Yoshino-Saito K, Yamanaka A, Yamamori T, Watakabe A, Mizukami H, Schnitzer MJ, Tanaka KF, Ushiba J, Okano H.
Calcium transient dynamics of neural ensembles in the primary motor cortex of naturally behaving monkeys.
Cell Rep 24(8):2191-2195, 2018. DOI:10.1016/j.celrep.2018.07.057 - Tatsunori Nishimura, Asuka Nakata, Xiaoxi Chen, Kurumi Nishi, Makiko Meguro-Horike, Soichiro Sasaki, Kenji Kita, Shin-ichi Horike, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Takahiko Murayama, Susumu Kohno, Chiaki Takahashi, Naofumi Mukaida, Seiji Yano, Tomoyoshi Soga, Arinobu Tojo, Noriko Gotoh
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Oncogene 38(14):2464-2481, 2018. DOI:10.1038/s41388-018-0589-1 - Umeda M, Koga T, Ichinose K, Igawa T, Sato T, Takatani A, Shimizu T, Fukui S, Nishino A, Horai Y, Hirai Y, Kawashiri S.-Y, Iwamoto N, Aramaki T, Tamai M, Nakamura H, Yamamoto K, Abiru N, Origuchi T, Ueki Y and Kawakami A
CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus.
Clinical Immunology 187:50-57, 2018. DOI:10.1016/j.clim.2017.10.004 - Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration.
Neurochem Int 119:190-198, 2018. DOI:10.1016/j.neuint.2018.01.003 - Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H.
Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
Scientific Reports 8:e14827, 2018. DOI:10.1038/s41598-018-33139-x - Morrison, S.F., Nakamura, K.
Central mechanisms for thermoregulation.
Annual Review of Physiology 81:285-308, 2018. DOI:10.1146/annurev-physiol-020518-114546 - Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR.
Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.
Cell Reports 24:2196-2210, 2018. DOI:10.1016/j.celrep.2018.07.056 - Ryo Tanifuji, Kento Koketsu, Michiko Takakura, Ryutaro Asano, Atsushi Minami, Hideaki Oikawa, Hiroki Oguri
Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3.
J. Am. Chem. Soc. 140(34):10705?10709, 2018. DOI:10.1021/jacs.8b07161 - Tomoaki Taniguchi, Akira Tsubouchi, Yuki Imai, Junpei Yuasa, Hiroki Oguri
Chiroptical Inversion of Europium(III) Complexes by Changing a Remote Stereogenic Center of a C2-symmetric Bispyrrolidinoindoline Manifold.
J. Org. Chem. 83(24):15284?15296, 2018. DOI:10.1021/acs.joc.8b02550 - Fukui, R., C. Yamamoto, F. Matsumoto, M. Onji, T. Shibata, Y. Murakami, A. Kanno, T. Hayashi, N. Tanimura, N. Yoshida, and K. Miyake.
Cleavage?of?Toll-Like Receptor 9?Ectodomain?Is?Required?for?In Vivo?Responses to Single Strand DNA.
Front Immunol 9:1491, 2018. DOI:10.3389/fimmu.2018.01491 - Noguchi K, Konno M, Eguchi H, Kawamoto K, Mukai R, Nishida N, Koseki J, Wada H, Akita H, Satoh T, Marubashi S, Nagano H, Doki Y, Mori M, Ishii H.
c-Met affects gemcitabine resistance during carcinogenesis in a mouse model of pancreatic cancer.
Oncol Lett 16(2):1892-1898, 2018. DOI:10.3892/ol.2018.8793 - Sato, R., A. Kato, T. Chimura, S. I. Saitoh, T. Shibata, Y. Murakami, R. Fukui, K. Liu, Y. Zhang, J. Arii, G. H. Sun-Wada, Y. Wada, T. Ikenoue, G. N. Barber, T. Manabe, Y. Kawaguchi, and K. Miyake.
Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.
Nat Immunol 19(10):1071-1082, 2018. DOI:10.1038/s41590-018-0203-2 - Aonuma H., Totani Y., Sakakibara M., Lukowiak K. and Ito E.
Comparison of brain monoamine content in three populations of Lymnaea that correlates with taste-aversive learning ability.
Biophys. Physicobiol. 15:129-135, 2018. DOI:10.2142/biophysico.15.0_129 - Ida-Yonemochi H, Morita W, Sugiura N, Kawakami R, Morioka Y, Takeuchi Y, Sato T, Shibata S, Watanabe H, Imamura T, Igarashi M, Ohshima H, Takeuchi K
Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.
Sci Rep 8:17134-, 2018. DOI:10.1038/s41598-018-35412-5 - Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T
Deficiency of AMPA receptor-palmitoylation aggravates seizure susceptibility.
Journal of Neuroscience 38:10220-10235, 2018. DOI:10.1523/JNEUROSCI.1590-18.2018 - Zhou L, Hossain MI, Yamazaki M, Abe M, Natsume R, Konno K, Kageyama S, Komatsu M, Watanabe M, Sakimura K, Takebayashi H.
Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype.
J Neurochem 147:557-572, 2018. DOI:10.1111/jnc.14591 - Karnakar Reddy Bonepally, Takahisa Hiruma, Haruki Mizoguchi, Kyohei Ochiai, Shun Suzuki, Hideaki Oikawa, Aki Ishiyama, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Omura, Hiroki Oguri
Design and De Novo Synthesis of 6-Aza-artemisinins.
Org. Lett. 20(15):4667?4671, 2018. DOI:10.1021/acs.orglett.8b01987 - Nana Tsuchiya, Yunosuke Ryu, Takahiro Muraoka, Hiroki Oguri
Design of C2-symmetric alkaloidal chiral amphiphiles and configurational effects on self-assembly.
Org. Biomol. Chem. 16:9305-9313, 2018. DOI:10.1039/C8OB02287A - Yue Ma, Yamato Tsushima, Mai Sakuma, Shogo Sasaki, Keisuke Iida, Sachiko Okabe, Hiroyuki Seimiya, Takatsugu Hirokawa, Kazuo Nagasawa
Development of G-quadruplex ligand for selective induction of parallel-type topology.
Org. Biomol. Chem. 16:7375-7382, 2018. DOI:10.1039/C8OB01702F - Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, and Komuro I.
Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury.
JACC:Basic to Translational Science 12;3(5):639-653, 2018. DOI:10.1016/j.jacbts.2018.07.005 - Brew N, Nakamura S, Hale, N. Azhan, A., Davies, G. I.
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Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia.
Pediatr Res 84(3):442-450, 2018. DOI:10.1038/s41390-018-0045-5 - Nagai, N., Ohguchi, H., Nakaki, R., Matsumura, Y., Kanki, Y., Sakai, J., Aburatani, H., and Minami, T
Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.
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Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice.
J Neurochem 147(3):344-360, 2018. DOI:10.1111/jnc.14486 - Takayama Y, Ando T, Ichikawa J, Haro H
Effect of Thrombin-Induced MCP-1 and MMP-3 Production Via PAR1 Expression in Murine Intervertebral Discs.
Sci Rep 8(1):11320, 2018. DOI:10.1038/s41598-018-29669-z - Ahmat Amin MKB, Shimizu A, Zankov DP, Sato A, Kurita S, Ito M, Maeda T, Yoshida T, Sakaue T, Higashiyama S, Kawauchi A, Ogita H.
Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1.
Oncogene 37:5416-5434, 2018. DOI:10.1038/s41388-018-0286-0 - Tanaka Y, Higurashi N, Shirasu N, Yasunaga S, Moreira KM, Okano H, Hirose S.
Establishment of a human induced stem cell line (FUi002-A) from Dravet syndrome patient carrying heterozygous R1525X mutation in SCN1A gene.
Stem Cell Research 31:11-15, 2018. DOI:10.1016/j.scr.2018.06.008 - Y. Yamashita, Y. Saito, S. Kikkawa, Y. Mutoh, S. Hosoya, I. Azumaya, S. Saito
Evaluation of the Steric Bulk of Substituents Utilizing the Shuttling Behavior of [2]Rotaxanes with N-Arylpyrrole Moieties.
EUR J ORG CHEM 2019:3412-3420, 2018. DOI:10.1002/ejoc.201801476 - Nakashima C, Yamamoto K, Fujiwara-Tani R, Luo Y, Matsushima S, Fujii K, Ohmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H
Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.
Cancer Sci 109(6):2036-2045, 2018. DOI:10.1111/cas.13594 - Aoyama K, Oshima M, Koide S, Suzuki E, Mochizuki-Kashio M, Kato Y, Tara S, Shinoda D, Hiura N, Nakajima-Takagi Y, Sashida G, Iwama A.
Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.
iScience 9:161-174, 2018. DOI:10.1016/j.isci.2018.10.008 - Wang C, Oshima M, Sato D, Matsui H, Kubota S, Aoyama K, Nakajima-Takagi Y, Koide S, Matsubayashi J, Mochizuki-Kashio M, Nakano-Yokomizo T, Bai J, Nagao T, Kanai A, Iwama A, Sashida G.
Ezh2 loss propagates hypermethylation at T-cell differentiation-regulating genes to promote leukemic transformation.
J Clin Invest 128(9):3872-86, 2018. DOI:10.1172/JCI94645 - Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
Jounal of Clinical Investigation 128(12):5603-5619, 2018. DOI:10.1172/JCI121679 - Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A.
FEAT enhances INSL3 expression in testicular Leydig cells.
Genes to cells 23:952-962, 2018. DOI:10.1111/gtc.12644 - Masaya Baba, Mitsuhiro Endoh, Wenjuan Ma, Hirofumi Toyama, Akiyoshi Hirayama, Keizo Nishikawa, Keiyo Takubo, Hiroyuki Hano, Hisashi Hasumi, Terumasa Umemoto, Michihiro Hashimoto, Nobuko Irie, Chiharu Esumi, Miho Kataoka, Naomi Nakagata, Tomoyoshi Soga, Masahiro Yao, Tomomi Kamba, Takashi Minami, Masaru Ishii, Toshio Suda
Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation.
Journal of Bone and Mineral Research 33(10):1785-1798, 2018. DOI:10.1002/jbmr.3477 - Sulistomo HW, Nemoto T, Yanagita T, Takeya R.
Formin homology 2 domain-containing 3 (Fhod3) controls neural plate morphogenesis in mouse cranial neurulation by regulating multidirectional apical c ….
J Biol Chem 294:2924-2934, 2018. DOI:10.1074/jbc.RA118.005471 - Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women: Chiba bone survey.
Endocr J 65(2):193-202, 2018. DOI:10.1507/endocrj.EJ17-0331 - Kaneko R, Kakinuma T, Sato S, Jinno-Oue A.
Freezing sperm in short straws reduces storage space and allows transport in dry ice.
J Reprod Dev. 64(6):541-545, 2018. DOI:10.1262/jrd.2018-100 - Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Ichikawa J, Osada M, Satoh K, Ozaki Y, Suzuki-Inoue K.
Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis.
J Thromb Haemost 16(5):960-972, 2018. DOI:10.1111/jth.13987 - Hayashida T, Saito Y, Ishii A, Hirose S, Hiraiwa R, Maegaki Y, Ohno K.
Further characterization of CAPOS/CAOS syndrome with the Glu818Lys mutation in the ATP1A3 gene: A case report.
Brain & Development 40(7):576-581, 2018. DOI:10.1016/j.braindev.2018.03.004 - Yokoshima Y, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Kato R, Hozumi J, Abe H, Azuma K, Tsuchida R, Yamada Y, Japanese TR-Cancer Pain Research Group.
Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain: An exploratory study.
Neuropsychopharmacology Report 38:175-181, 2018. DOI:10.1002/npr2.12030 - Kuriyama Y, Hattori M, Mitsui T, Nakano H, Oikawa D, Tokunaga F, Ishikawa O, Shimizu A.
Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency.
Journal of Dermatology 45(5):e108-e109, 2018. DOI:10.1111/1346-8138 - Shiori Miura, Yoshitaka Maeda, Jun Miyamoto, Ena Nakatsukasa, Nobuyoshi Fujisawa, Miki Miwa, Katsuki Nakamura, Kenji Sakimura and Toshikuni Sasaoka
Generation of functional oocytes of common marmoset by xeno-transplantation of ovarian tissue.
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Generation of rat monoclonal antibodies against a deubiquitinase, ovarian tumor domain-containing protein 1.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 37(4):180-184, 2018. DOI:10.1089/mab.2018.0023 - Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
Generation of rat monoclonal antibodies specific for DZIP3.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 37(3):153-157, 2018. DOI:10.1089/mab.2018.0005 - Orr? C*, Szydlowska M*, Taguchi K*, Zavattari P, Perra A, Yamamoto M, Columbano A
Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis.
J Hepatol 69:635-643, 2018. DOI:10.1016/j.jhep.2018.05.010 - Ito-Ishida A, Yamalanchili HK, Shao Y, Baker SA, Heckman LD, Lavery LA, Kim JY, Lombardi LM, Sun Y, Liu Z, Zoghbi HY.
Genome-wide distribution of linker histone H1.0 is independent of MeCP2.
Nature Neuroscience 21(6):794-798, 2018. DOI:10.1038/s41593-018-0155-8 - Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Miyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T.
Glucagonoma With Necrolytic Migratory Erythema: Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.
J Clin Endocrinol Metab 103(7):2417-2423, 2018. DOI:10.1210/jc.2017-02646 - Nishihara S
Glycans in stem cell regulation: from Drosophila tissue stem cells to mammalian pluripotent stem cells.
FEBS Lett. 592(23):3773-3790, 2018. DOI:10.1002/1873-3468.1316 - Maruzuru, Y., T. Ichinohe, R. Sato, K. Miyake, T. Okano, T. Suzuki, T. Koshiba, N. Koyanagi, S. Tsuda, M. Watanabe, J. Arii, A. Kato, and Y. Kawaguchi.
Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.
Cell Host Microbe 23(2):254-265, 2018. DOI:10.1016/j.chom.2017.12.014 - Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
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SLAS Discovery 23(10):1018-1029, 2018. DOI:10.1177/2472555218793066 - Yamauchi Y., Itoh S. et al.
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Hunger and satiety signaling: Modeling two hypothalamomedullary pathways for energy homeostasis.
BioEssays 40:1700252, 2018. DOI:10.1002/bies.201700252 - Mori R, Tanaka K, Shimokawa I
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Dev Growth Differ 60(6):306-315, 2018. DOI:10.1111/dgd.12542 - Watanabe T., Ugajin A. and Aonuma H.
Immediate-early promoter-driven transgenic reporter system for neuroethological researches in a hemimetabolous insect.
eNeuro 5:e0016-18, 2018. DOI:10.1523/ENEURO.0061-18.2018 - Shadi Sedghi Masoud, Kazuo Nagasawa
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Nature Communications 9:2081, 2018. DOI:10.1038/s41467-018-04449-5 - Ikoma Y, Kusumoto-Yoshida I, Yamanaka A, Ootsuka Y, Kuwaki T.
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Front Physiol 9:832, 2018. DOI:10.3389/fphys.2018.00832 - Okazaki S, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Kinoshita M, Inoue E, Ohmori T, Someya T, Sora I.
Increased Serum Levels and Promoter Polymorphisms of Macrophage Migration Inhibitory Factor in Schizophrenia.
Prog Neuropsychopharmacol Biol Psychiatry 83:33-41, 2018. DOI:10.1016/j.pnpbp.2018.01.001 - Okazaki S ; Hishimoto A ; Otsuka I ; Watanabe Y ; Numata S ; Boku S ; Shimmyo N ; Kinoshita M ; Inoue M ; Ohmori T ; Someya T ; Sora I
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Prog Neuropsychopharmacol Biol Psychiatry 83:33-41, 2018. DOI:10.1016/j.pnpbp.2018.01.001 - Takizawa H*, Hayashi Y
Inflammation and early hematopoiesis.
Rinsho Ketsueki 59:1955-1961, 2018. DOI:10.11406/rinketsu.59.1955 - Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki SI, Wakamatsu K, Tokunaga F, Shimizu A.
In-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.
Journal of Dermatological Science 91(1):35-42, 2018. DOI:10.1016/j.jdermsci.2018.03.012 - Miyagawa Y, Mori T, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Ohmori H, Kawahara I, Kuniyasu H
Intake of medium-chain fatty acids induces oxidative stress and to atrophy the myocardium.
Lipids in Health and Disease 17:258, 2018. DOI:10.1186/s12944-018-0908-0 - Matsuyama S, Kage Y, Fujimoto N, Ushijima T, Tsuruda T, Kitamura K, Shiose A, Asada Y, Sumimoto H, Takeya R.
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Proc Natl Acad Sci U S A. 115(19):E4386-E4395, 2018. DOI:10.1073/pnas.1716498115 - Shimamura M, Yamamoto K, Kurashige T, Nagayama Y
Intracellular redox status controls spherogenicity, an?in vitro?cancer stem cell marker, in thyroid cancer cell lines.
Experimental Cell research 370(2):699-707, 2018. DOI:10.1016/j.yexcr.2018.07.036 - Hirata T ; Hishimoto A ; Otsuka I ; Okazaki S ; Boku S ; Kimura A ; Horai T ; Sora I
Investigation of chromosome Y loss in men with schizophrenia.
Neuropsychiatr Dis Treat 14:2115-2122, 2018. DOI:10.2147/NDT.S172886 - Takeuchi Y., Kito A. et al.
Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling.
Exp. Cell Res. 371(2):417-425, 2018. DOI:10.1016/j.yexcr.2018.09.002 - Sasaki K ; Hall FS ; Uhl GR ; Sora I
Larger Numbers of Glial and Neuronal Cells in the Periaqueductal Gray Matter of μ-Opioid Receptor Knockout Mice.
Front Psychiatry 9:441, 2018. DOI:10.3389/fpsyt.2018.00441 - Zhang Y ; Hishimoto A ; Otsuka I ; Watanabe Y ; Numata S ; Yamamori H ; Boku S ; Horai T ; Someya T ; Ohmori T ; Hashimoto R ; Sora I
Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population.
J Psychiatr Res 103:161-166, 2018. DOI:10.1016/j.jpsychires - Kimura A, Hishimoto A, Otsuka I, Okazaki S, Boku S, Horai T, Izumi T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
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PLoS One 13(1):e0190667, 2018. DOI:10.1371/journal.pone.0190667 - Tsukahara, R., Yamamoto, S., Yoshikawa, K., Gotoh, M., Tsukahara, T., Neyama, H., Ishii, S., Akahoshi, N., Yanagida, K., Sumida, H., Araki, M., Araki, K., Yamamura, K. I., Murakami-Murofushi, K., Ueda, H.
LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.
J. Pharmacol.Sci. 136:93-96, 2018. DOI:10.1016/j.jphs.2018.01.001 - Hideaki ABE, Manabu NATSUMEDA, Yu KANEMARU, Jun WATANABE, Yoshihiro TSUKAMOTO, Masayasu OKADA, Junichi YOSHIMURA, Makoto OISHI, and Yukihiko FUJII
MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas.
Neurol Med Chir (Tokyo) 58:290-295, 2018. DOI:10.2176/nmc.ra.2018-0044 - Takeda A, Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J, Koizumi S.
Microglia mediate non-cell autonomous cell death of retinal ganglion cells.
GLIA 66:2366-2384, 2018. DOI:10.1002/glia.23475 - Kokuda R, Watanabe R, Okuzaki D, Akamatsu H, Oneyama C.
MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression.
Genes Cells 23(8):688-701, 2018. DOI:10.1111/gtc.12610 - Yamaki N ; Otsuka I ; Numata S ; Yanagi M ; Mouri K ; Okazaki S ; Boku S ; Horai T ; Ohmori T ; Shirakawa O ; Sora I ; Hishimoto A
Mitochondrial DNA copy number of peripheral blood in bipolar disorder: The present study and a meta-analysis.
Psychiatry Res 269:115-117, 2018. DOI:10.1016/j.psychres - Takaoka, Y., Konno, M., Koseki, J., Colvin, H., Asai, A., Tamari, K., Satoh, T., Mori, M., Doki, Y., Ogawa, K., Ishii, H.
Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance.
Cancer Sci. 110:1331-1339, 2018. DOI:10.1111/cas.13980 - Fink J, Jackney A, Matsumoto M, Maekawa T, Nkazato K, Horie S.
Mobility and biomechanical functions in the aging male: testosterone and the Locomotive Syndrome.
Aging Male 29:1-8, 2018. DOI:10.1080/13685538.2018.1504914 - Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, *Isomura Y, *Kimura M
Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways.
Neuron 99(6):1302-1314, 2018. DOI:10.1016/j.neuron.2018.08.002 - Kano M, Watanabe T, Uesaka N, Watanabe M.
Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum.
Cerebellum. 17(6):722?734, 2018. DOI:10.1007/s12311-018-0964-z - Someya, M. and Ogawa, H.
Multisensory enhancement of burst activity in an insect auditory neuron.
J Neurophysiol. 120:139-148., 2018. DOI:10.1152/jn.00798.2017 - Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T.
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.
Nature Commun. 9(1):2733, 2018. DOI:10.1038/s41467-018-05085-9 - Hirotaka Watanabe, et al.
Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition With the Neighboring Normal Epithelial Cells.
Cell Reports 23:3721-3729, 2018. DOI:10.1016/j.celrep.2018.05.081 - Tamiya Y ; Ouchi A ; Chen R ; Miyazawa S ; Akimoto Y ; Kaneda Y ; Sora I
Neurocognitive Impairments Are More Severe in the Binge-Eating/Purging Anorexia Nervosa Subtype Than in the Restricting Subtype.
Front Psychiatry 138:9, 2018. DOI:10.3389/fpsyt.2018.00138 - Matsui S, Sasaki T, Kohno D, Yaku K, Inutsuka A, Yokota-Hashimoto H, Kikuchi O, Suga T, Kobayashi M, Yamanaka A, Harada A, Nakagawa T, Onaka T, Kitamura T.
Neuronal sirt1 regulates macronutrient-based diet selection through fgf21 and oxytocin signalling in mice.
Nat Commun 9(1):4604, 2018. DOI:10.1038/s41467-018-07033-z - Sasahira T, Nishiguchi Y, Kurihara-Shimomura M, Nakashima C, Kuniyasu H, Kirita T.
NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma.
J Cancer Res Clin Oncol 144(5):875-882, 2018. DOI:10.1007/s00432-018-2612-x - Tel-Karthaus N, Kers-Rebel ED, Looman MW, Ichinose H, de Vries CJ, Ansems M
Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function.
Front Immunol 9:1797, 2018. DOI:10.3389/fimmu.2018.01797. - Nakatsumi H., Oka T., Higa T., Shirane M., Nakayama KI.
Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1.
Genes Cells 23:599-605, 2018. DOI:10.1111/gtc.12597 - Thannickal TC, John J, Shan L, Swaab DF, Wu MF, Ramanathan L, McGregor R, Chew KT, Cornford M, Yamanaka A, Inutsuka A, Fronczek R, Lammers GJ, Worley PF, Siegel JM.
Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy.
Sci Transl Med 10, 2018. DOI:10.1126/scitranslmed.aao4953 - Asano T, Igarashi H, Ishizuka T, Yawo H
Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light.
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p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells.
Proc Natl Acad Sci U S A. 115(33):8370-8375, 2018. DOI:10.1073/pnas.1804243115 - S?nchez-Mart?n P, Komatsu M.
p62/SQSTM1 - steering the cell through health and disease.
J Cell Sci. 131, 2018. DOI:10.1242/jcs.222836 - S?nchez-Mart?n P, Saito T, Komatsu M.
p62/SQSTM1: 'Jack of all trades' in health and cancer.
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p63-dependent Dickkopf3 expression promotes esophageal cancer cell proliferation via CKAP4.
Cancer Res. 78:3471-3484, 2018. DOI:10.1158/0008-5472.CAN-18-1749 - Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T, Kuniyasu H
Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma.
Histopathol 70(4):539-548, 2018. DOI:10.1111/his.13097 - Heiss JE, Yamanaka A, Kilduff TS.
Parallel arousal pathways in the lateral hypothalamus.
eNeuro 5, 2018. DOI:10.1523/ENEURO.0228-18.2018 - Black SW, Sun JD, Santiago P, Laihsu A, Kimura N, Yamanaka A, Bersot R, Humphries PS
Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration.
Sleep 41(9), 2018. DOI:10.1093/sleep/zsy116 - Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger G, Wang J, Dong Y, Zhou Y, Wang J, Wu LY, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, et al.
Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
Cancer Discovery 8(11):1438-57, 2018. DOI:10.1158/2159-8290.CD-17-1203 - Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H
Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes.
Chem Res Toxicol 31(10):1025-1031, 2018. DOI:10.1021/acs.chemrestox.8b00067 - Yu Chen, Masahiro Takikawa, Shuichi Tsutsumi, Yoko Yamaguchi, Atsushi Okabe, Mayuna Shibata, Tatsuya Kawase, Akane Sada, Issei Ezawa, Yuhei Takano, Kisaburo Nagata, Yutaka Suzuki, Kentaro Semba, Hiroyuki Aburatani, Rieko Ohki.
PHLDA1, another PHLDA family protein that inhibits Akt.
Cancer Science 109:3532-3542, 2018. DOI:10.1111/cas.13796 - Yashiro R, Murota Y, Nishida KM, Yamashiro H, Fujii K, Ogai A, Yamanaka S, Negishi L, Siomi H, Siomi MC.
Piwi Nuclear Localization and Its Regulatory Mechanism in Drosophila Ovarian Somatic Cells.
Cell Reports 23:3647-3657, 2018. DOI:10.1016/j.celrep.2018.05.051 - Saito M, Ichikawa J, Ando T, Schoenecker JG, Ohba T, Koyama K, Suzuki-Inoue K, Haro H.
Platelet-Derived TGF-β Induces Tissue Factor Expression via the Smad3 Pathway in Osteosarcoma Cells.
J Bone Miner Res. 33(11):2048-2058, 2018. DOI:10.1002/jbmr - Toshiyama, R., Konno, M., Eguchi, H., Takemoto, H., Noda, T., Asai, A., Koseki, J., Haraguchi, N., Ueda, Y. Matsushita, K., Asukai, K., Ohashi, T., Iwagami, Y., Yamada, D., Sakai, D., Asaoka, T., Kudo, T., Kawamoto, K., Gotoh, K., Kobayashi, S., Satoh, T., Doki, Y., Nishiyama, N., Mori, M.
Poly(ethylene glycol)?poly(lysine) block copolymer?ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.
Oncogene, 2018. DOI:10.1038/s41388-018-0406-x - Tamari, K., Konno, M., Asai, A., Koseki., Jun., Hayashi, K., Kawamoto, K., Murai, N., Matsufuji, S., Isohashi, F., Satoh, T., Goto, N., Tanaka, S., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells.
Cell Death Discovery 4(104), 2018. DOI:10.1038/s41420-018-0117-7 - Fink J, Matsumoto M, Tamura Y.
Potential application of testosterone replacement therapy as treatment for obesity and type 2 diabetes in men.
Steroids 161:161-166., 2018. DOI:10.1016/j.steroids.2018.08.002 - Koide H, Shiga A, Komai E, Yamato A, Fujimoto M, Tamura A, Kono T, Nakayama A, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Suzuki S, Takeda Y, Shibuya M, Nishioka H, Yamada S, Inoshita N, Ishiwatari N, Horiguchi K, Yokote K, Tanaka T.
Prednisolone-responsive Postpartum IgG4-related Hypophysitis.
Intern Med 57(3):367-375, 2018. DOI:10.2169/internalmedicine - Miyazawa, Y., Takahashi, Y., Watabe, A.M. and Kato F.
Predominant synaptic potentiation and activation of the right central amygdala are independent of bilateral paracrachial activation in the hemilateral trigeminal inflammatory pain model of rats.
Molecular Pain :14:1744806918807102, 2018. DOI:10.1177/1744806918807102 - Ng IK, Lee J, Ng C, Kosmo B, Chiu L, Seah E, Mok MMH, Tan K, Osato M, Chng WJ, Yan B, Tan LK.
Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation.
Biomark Res. 6:16, 2018. DOI:10.1186/s40364-018-0130-2 - Aoto Y, Okumura K, Hachiya T, Hase S, Sato K, Wakabayashi Y, Ishikawa F and Sakakibara Y.
Prospective study of the tumorigenesis process with an experimental carcinogenesis model.
Scientific Reports 8(1):12994, 2018. DOI:10.1038/s41598-018-31349-x - Abe K, Yawo H.
Quantitative study of the somatosensory sensitization underlying cross-modal plasticity.
PLoS One 13(12):e0208089, 2018. DOI:10.1371/journal.pone.0208089 - Tocan V, Ohkubo K, Higashi K, Toda N, Kojima-Ishii K, Nishiyama K, Ishimura M, Takada H, Sakamoto O, Sasaki F, Yoshimura K, Hirose S, Ohga S.
Reappraising newborn screening for cobalamin C disorder.
Pediatrics & Neonatology 59(4):415-417, 2018. DOI:10.1016/j.pedneo.2017.11.002 - Motohiro Kojima, Yu Chen, Koji Ikeda, Yuichiro Tsukada, Daigoro Takahashi, Shingo Kawano, Kota Amemiya, Masaaki Ito, Rieko Ohki, Atsushi Ochiai.
Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients.
Scientific Reports 9(1):2404, 2018. DOI:10.1038/s41598-018-37707-z - Sakamoto, K., Katayama, R., Asaka, R., Sakata, S., Baba, S., Nakasone, H., Takakuwa, E., Yamazaki, R., Takizawa, J., Maeda, T., Narita, M., Izutsu, K., Kanda, Y., Ohshima, K. and *Takeuchi, K.,
Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response.
Leukemia 32:2590?2603, 2018. DOI:10.1038/s41375-018-0154-5 - Watanabe E, Fujita T, Shimono M, Koike H, Yasumoto S, Hirose S.
Recurrent autonomic and sensory neuropathy in a patient with anti-ganglionic acetylcholine receptor antibodies.
eNeurologicalSci 12:36-38, 2018. DOI:10.1016/j.ensci.2018.08.001 - Shen YC, Sasaki T, Matsuyama T, Yamashita T, Shichida Y, Okitsu T, Yamano Y, Wada A, Ishizuka T, Yawo H, Imamoto Y.
Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues.
Biochemistry 57(38):5544-5556, 2018. DOI:10.1021/acs.biochem.8b00583 - Mon, E.E., *Wei, F.-Y., Ahmad, R.N.R., Yamamoto, T., Moroishi, T., *Tomizawa, K.
Regulation of mitochondrial iron homeostasis by sideroflexin 2.
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Regulatory role of resveratrol, a microRNA-controlling compound, in?HNRNPA1?expression, which is associated with poor prognosis in breast cancer.
Oncotarget 9(37):24718-24730, 2018. DOI:10.18632/oncotarget.25339 - Jinnai, W. Nakamura, S. Koyano, K. Yamato, S.
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Brain Dev 40(8):649-661, 2018. DOI:10.1016/j.braindev.2018.04.010 - Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
Resting-state functional connectivity analysis of the mouse brain using intrinsic optical signal imaging of cerebral blood volume dynamics.
Physiological Measurement 39:54003, 2018. DOI:10.1088/1361-6579/aac033 - Miyazaki K, Miyazaki KW, Yamanaka A, Tokuda T, Tanaka KF, Doya K.
Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience.
Nat Commun 9:2048, 2018. DOI:10.1038/s41467-018-04496-y - Ide S ; Ikekubo Y ; Hua J ; Takamatsu Y ; Uhi GR ; Sora I
Reward-enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice: A model of attention-deficit/hyperactivity disorder.
Neuropsychopharmacol Rep 38:149-153, 2018. DOI:10.1002/npr2.12020 - Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
Cancer Science 109(12):4003-4014, 2018. DOI:10.1111/cas.13805 - Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N
Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.
Int J Mol Sci. 19(6):E1811, 2018. DOI:10.3390/ijms19061811 - Takuma Watanabe, Haruka Abe, Yuichiro Mutoh, and Shinichi Saito
Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylstyrenes via 1,2-Carbon Migration that Leads to Substituted Naphthalenes.
CHEMISTRY-A EUROPEAN JOURNAL 24:11545-11549, 2018. DOI:10.1002/chem.201802413 - Hashimoto Y, Hata T, Tada M, Iida M, Watari A, Okada Y, Doi T, Kuniyasu H, Yagi K, Kondoh M
Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2.
Eur J Pharm Sci 117:161-167, 2018. DOI:10.1016/j.ejps.2018.02.016 - Koso H, Nishinakamura R, Watanabe S
Sall1 regulates microglial morphology cell autonomously in the developing retina.
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Self-organizing Cortex Generated From Human iPSCs With Combination of FGF2 and Ambient Oxygen.
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Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.
Proc. Natl. Acad. Sci. U. S. A. 116:625-630, 2018. DOI:10.1073/pnas.1806851116 - Matsushima-Otsuka S, Fujiwara-Tani R, Sasaki T, Ohmori H Nakashima C, Kishi S, Nishiguchi Y, Fujii K, Luo Y, Kuniyasu H
Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma.
Oncotarget 9(93):36561-36574, 2018. DOI:10.18632/oncotarget.26337 - Fukuda M, Yoshizawa T, Karim MF, Sobuz SU, Korogi W, Kobayashi D, Okanishi H, Tasaki M, Sawa T, Oike Y, Araki N, Takeda S, Mizuta H, Yamagata K
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
Nat. Commun. 9:2833, 2018. DOI:10.1038/s41467-018-05187-4 - Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K
SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.
Biochem Biophys Res Commun 496:891-897, 2018. DOI:10.1016/j.bbrc.2018.01.129 - Miyasato Y, Yoshizawa T, Sato Y, Nakagawa T, Miyasato Y, Kakizoe Y, Kuwabara T, Adachi M, Lanni A, Braun T, Komohara Y, Mukoyama M, Yamagata K
Sirtuin 7 deficiency ameliorates cisplatin-induced acute kidney injury through regulation of the inflammatory responses.
Sci Rep 8:5927, 2018. DOI:10.1038/s41598-018-24257-7 - Tsuge M, Osaki M, Sasaki R, Hirahata M, Okada F
SK-216, a novel inhibitor of plasminogen activator inhibitor-1, suppresses lung metastasis of human osteosarcoma.
Int J Mol Sci 19(3):736, 2018. DOI:10.3390/ijms19030736 - Mitsuko Furuya, Hironori Kobayashi, Masaya Baba, Takaaki Ito, Reiko Tanaka, Yukio Nakatani
Splice-site mutation causing partial retention of intron in the FLCN gene in Birt-Hogg-Dub? syndrome: a case report.
BMC medical genomics 11, 2018. DOI:10.1186/s12920-018-0359-5 - Sumiyoshi K, Koso H, Watanabe S.
Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma.
Cancer Sci. 109(5):1513-1523, 2018. DOI:10.1111/cas.13579 - Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T*, Sato K
Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis.
Mol Cancer Res 16(3):554-563, 2018. DOI:10.1158/1541-7786.MCR-17-0393 - Shimizu Y1, Tamada S1, Kato M1, Takeyama Y1, Fujioka M2, Kakehashi A2, Nakatani T1, Wanibuchi H2, Gi M2.
Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer.
Exp Ther Med 16(6):4463-4470, 2018. DOI:10.3892/etm.2018.6787 - Zhang, Z., U. Ohto, T. Shibata, M. Taoka, Y. Yamauchi, R. Sato, N. M. Shukla, S. A. David, T. Isobe, K. Miyake, and T. Shimizu.
Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep 25(12):3371-3381, 2018. DOI:10.1016/j.celrep.2018.11.081 - Ishida, H., U. Ohto, T. Shibata, K. Miyake, and T. Shimizu.
Structural basis for species-specific activation of mouse Toll-like receptor 9.
FEBS Lett 592(15):2636-2646, 2018. DOI:10.1002/1873-3468.13176 - Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Ishitani R, Tokunaga F, Kasuya G, Nureki O.
Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
Nat Commun. 9:4424, 2018. DOI:10.1038/s41467-018-06922-7 - Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ.
Study on the tumor-induced angiogenesis using mathematical models.
Cancer Science 109:15-23, 2018. DOI:10.1111/cas.13395 - Akatsuka S, Li GH, Toyokuni S
Superiority of rat over murine model for studies on the evolution of cancer genome.
Free Radical Research 52:1323-1327, 2018. DOI:10.1080/10715762.2018.1467562 - Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output.
Cell Rep. 25:2704-2715, 2018. DOI:10.1016/j.celrep.2018.11.016 - Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S. and Irie, K.
Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin.
Heterocycles 97(1):478-492, 2018. DOI:10.3987/COM-18-S(T)37 - Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
Systematic review of pre-clinical chronic myeloid leukaemia.
Int J Hematol. 108(5):465-484, 2018. DOI:10.1007/s12185-018-2528-x - Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H
Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
Sci Rep. 8(1):5435, 2018. DOI:10.1038/s41598-018-23810-8 - de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu To, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R
Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds.
EMBO Mol Med 10(10):e9024, 2018. DOI:10.15252/emmm.201809024 - Okada K, Nishizawa K, Setogawa S, Hashimoto K, Kobayashi K.
Task-dependent function of striatal cholinergic interneurons.
Eur J Neurosci 47(10):1174-1183., 2018. DOI:10.1111/ejn.13768 - Kita Y., Katayama Y., Shiraishi T., Oka T., Sato T., Suyama M., Ohkawa Y., Miyata K., Oike Y., Shirane M., Nishiyama M., Nakayama KI.
The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.
Cell Rep. 23:1988-2000, 2018. DOI:10.1016/j.celrep.2018.04.050 - Matsumoto A., Nakayama KI.
The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.
Cell Struct. Funct. 43:75-83, 2018. DOI:10.1247/csf.18005 - Pelka, K., D. Bertheloot, E. Reimer, K. Phulphagar, S. V. Schmidt, A. Christ, R. Stahl, N. Watson, K. Miyake, N. Hacohen, A. Haas, M. M. Brinkmann, A. Marshak-Rothstein, F. Meissner, and E. Latz.
The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.?.
Immunity 48(5):911-922, 2018. DOI:10.1016/j.immuni.2018.04.011 - Lorente J, Velandia C, Leal JA, Garcia-Mayea Y, Lyakhovich A, Kondoh H, LLeonart ME.
The interplay between autophagy and tumorigenesis: exploiting autophagy as a means of anticancer therapy.
Biol Rev Camb Philos Soc. 93, 1:P152?165, 2018. DOI:10.1111/brv.12337 - Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H, Kirita T.
The multifarious functions of pyruvate kinase M2 in oral cancer cells.
Int J Mol Sci 19:2907, 2018. DOI:10.3390/ijms19102907 - Jin F, Li X, Deng Y, Timilshina M, Huang B, Kim DY, Chang JH, Ichinose H, Baek SH, Murakami M, Lee YJ, Chang HW
The orphan nuclear receptor NR4A1 promotes FcepsilonRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis.
Allergy 74(6):1145-1156, 2018. DOI:10.1111/all.13702 - Okumura K, Saito M, and Wakabayashi Y.
The role of PTH in mouse skin tumorigenesis.
Integrative Cancer Science and Therapeutics 5:2, 2018. DOI:10.15761/ICST.1000271 - Kawamura Y, Yamanaka K, Poh B, Kuribayashi H, Koso H, Watanabe S
The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development.
Biochem Biophys Res Commun 503(4):3023-3030, 2018. DOI:10.1016/j.bbrc.2018.08.088 - M. Ishido*
The temporal turning window for rat behavioral phenotypes by rotenone.
Fund. Toxicol. Sci. 5, 2018. - Ihara T,Mitsui T,Nakamura Y,Kanda M,Tsuchiya S,Kira S,Nakagomi H,Sawada N,kamiyama M, Shigetomi E,Shinozaki Y,Yoshiyama M,Nakao A,Takeda M,Koizumi S.
The time-dependent variation of ATP release in mouse primary-cultured urothlial cells is regulated by the clock gene.
Neurourol Urodym. 37:2535-2543, 2018. DOI:10.1002/nau.23793 - Futakuchi M, Nitanda T, Ando S, Matsumoto H, Yoshimoto E, Fukamachi K, Suzui M
Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment.
Int J Mol Sci 19(3), 2018. DOI:10.3390/ijms19030888 - Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama S
Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells.
Scientific Reports 8:6760, 2018. DOI:10.1038/s41598-018-25189-y - Ohto, U., H. Ishida, T. Shibata, R. Sato, K. Miyake, and T. Shimizu.
Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.?.
Immunity 48(4):649-658, 2018. DOI:10.1016/j.immuni.2018.03.013 - Kurihara Y, Makita Y, Kawashima M, Fujita T, Iwasaki S, and Matsui M.
Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis.
Proc Natl Acad Sci USA 115(30):7831-7836, 2018. DOI:10.1073/pnas.1804971115 - Maeda A, Nishino T, Matsuzaki R, Yokoyama A, Suga H, Yagi T, Konishi H.
Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling.
Biochim Biophys Acta Mol Cell Res. 1866:285-295, 2018. DOI:10.1016/j.bbamcr.2018.11.009 - Momohara Y., Aonuma H. and Nagayama T.
Tyraminergic modulation of agonistic outcomes in crayfish.
J. Comp. Physiol. 204:465-473, 2018. DOI:10.1007/s00359-018-1255-3 - Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K,
Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.
UBL3 modification influences protein sorting to small extracellular vesicles.
Nature Communications 9:3936, 2018. DOI:10.1038/s41467-018-06197-y - Taiwa K, Yokoi S, Mito M2, Fujii K, Kimura Y, Iwasaki S, Nakagawa S.
UPA-Seq: Prediction of Functional LncRNAs Using Differential Sensitivity to UV Crosslinking.
RNA 24(12):1785-1802., 2018. DOI:10.1261/rna.067611.118 - Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Nameta M, Zhang L, Iwakura Y, Nawa H, Higuchi M, Komatsu M, Fujii M.
USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis.
iScience. 9:433-450, 2018. DOI:10.1016/j.isci.2018.11.006 - Shimizu A, Zankov DP, Kurokawa-Seo M, Ogita H.
Vascular endothelial growth factor-A exerts diverse cellular effects via small G proteins, Rho and Rap.
Int J Mol Sci 19:E1203, 2018. DOI:10.3390/ijms19041203 - Huizi Li, Aya Sugyo, Atsushi Tsuji, Yukie Morokoshi, Katsuyuki Minegishi, Kotaro Nagatsu, Hiroaki Kanda, Yosuke Harada, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Tatsuya Higashi, Sumitaka Hasegawa
α-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibody against frizzled homolog 10.
Cancer Science 109(7):2302-2309, 2018. DOI:10.1111/cas.13636 - Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H.
β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.
PLoS ONE 13(5):e0196946, 2018. DOI:10.1371/journal.pone.0196946 - 佐藤信吾
がん骨転移のメカニズムの新知見と創薬への可能性.
PHARM STAGE 18(3):54-58, 2018. - 佐藤信吾
がん細胞由来分泌型マイクロRNAが造骨型骨転移を惹起する.
臨床雑誌整形外科 69(11):1124, 2018. - Kojiro Ishibashi, Riku Egami, Kazuki Nakai, Shunsuke Kon
がん変異細胞が産生されたときの代謝変化に関する総説.
Cell Structure and Function 43:171-176, 2018. DOI:10.1247/csf.18018 - Vu HT, Kobayashi M, Hegazy AM, Tadokoro Y, Ueno M, Kasahara A, Takase Y, Nomura N, Peng H, Ito C, Ino Y, Todo T, Nakada M, Hirao A.
グリオーマ幹細胞の治療抵抗性におけるオートファジーの役割.
Cancer Sci 109:2497-2508, 2018. DOI:10.1111/cas.13695 - 和田裕一, 三浦知志, 窪俊一
マンガの読みにおける状況モデルの更新.
マンガ研究 24:93-114, 2018. - 外川 龍之介, 奥畑 大悟, 吉田 侑冬，中尾 光之, 片山 統裕
眼位・瞳孔径変動を考慮した内因性光信号イメージングに基づく覚醒時マウス脳視野地図の推定.
生体医工学 :in press, 2018. - Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi N, Hirao A
高脂肪食ストレスによる幹細胞制御の破綻.
Cell Stem Cell 22:713-725, 2018. DOI:10.1016/j.stem.2018.04.002 - Zhang Y, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Yamamori H, Boku S, Horai T, Someya T, Ohmori T, Hashimoto R, Sora I
高齢の統合失調症におけるより長いテロメアと、日本人の長期入院との関連.
J Psychiatr Res. 103:161-166, 2018. DOI:10.1016/j.jpsychires.2018.05.014 - Shunsuke Kon.
細胞競合の生理的、病理的な役割に関する総説.
Development, Growth and Differentiation 60:14-20, 2018. DOI:10.1111/dgd.12415 - 岡田正康, 棗田学, 河嵜麻実, 大石誠, 藤井幸彦, 五十嵐道弘
細胞突起形成抑制による膠芽腫治療戦略.
新潟県医師会報 814(1):9-10, 2018. - 古瀬 民生, 若菜 茂晴
胎児期栄養は発達障害の環境要因となりうるのか.
日本衛生学雑誌 73:97-100, 2018. DOI:10.1265/jjh.73.97 - 石堂正美
超低周波電磁界の神経幹細胞に及ぼす影響評価に関する研究.
磁気と健康 30:20-25, 2018. - Nakamura S, Koyama T, Izawa N, Nomura S, Fujita T, Omata Y, Minami T, Matsumoto M, Nakamura M, Fujita-Jimbo E, Momoi T, Miyamoto T, Aburatani H, Tanaka S
Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.
PLoS One 12(4):e0175632, 2017. DOI:10.1371/journal.pone.0175632
2017年度
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Dasatinib exacerbates splenomegaly of mice inoculated with Epstein-Barr virus-infected lymphoblastoid cell lines.
Sci Rep. 10(1):4355, 2020. - T. Yamada, A. Tanaka, T. Nehira, T. Nishii, T. Kikuchi
Altercrasins A-E, decalin derivatives, from a sea-urchin-derived Alternaria sp.: isolation and structural analysis including stereochemistry.
Marine Drugs 17:218, 2019. DOI:10.3390/md17040218 - T. Yamada, A. Fujii, T. Kikuchi
New diterpenes with a fused 6-5-6-6 ring system isolated from the marine sponge-derived fungus Trichoderma harzianum.
Marine Drugs 17:480, 2019. DOI:10.3390/md17080480 - Ito T, Oti T, Takanami K, Satoh K, Ueda Y, Sakamoto T, Sakamoto H.
A sexually dimorphic peptidergic system in the lower spinal cord controlling penile function in non-human primates.
Spinal cord 56(1):57-62, 2018. DOI:10.1038/sc.2017.105 - Yamada T, Imamachi N, Onoguchi-Mizutani R, Imamura K, Suzuki Y, Akimitsu N
5'-Bromouridine IP Chase (BRIC)-Seq to Determine RNA Half-Lives.
Methods Mol Biol 1720:1-13, 2018. DOI:10.1007/978-1-4939-7540-2_1 - Inoue D, Fujino T, Sheridan P, Zhang Yz, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata KC, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang FC, Oyama M, Kitamura T
A novel ASXL1?OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.
Leukemia 32(6):1327-1337, 2018. DOI:10.1038/s41375-018-0083-3 - Meikui Wu,Makoto Takemoto,Huan Luo,Jian-Jun Xu,Mei-Hong Lu,Masaki Kameyama,Toru Takumi,Wen-Jie Song.
A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1.
Eur J Pharmacology 824:99-107, 2018. DOI:10.1016/j.ejphar.2018.02.013 - Shinno, N., Kimura, H., Sada, R., Takiguchi, S., Mori, M., Fumoto, K., Doki, Y., and Kikuchi, A.
Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.
Oncogene 37:6107-6120, 2018. DOI:10.1038/s41388-018-0179-2 - Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y, Muto A, Okano H,?Yamanaka A, Tawfik VL, Kuzumaki N, Navratilova E, Porreca F, *Narita M.
Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer.
Molecular Pain 14:1744806918756400, 2018. DOI:10.1177/1744806918756406 - Ueno H, Takao K, Suemitsu S, Murakami S, Kitamura N, Wani K, Okamoto M, Aoki S, Ishihara T
Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex.
Neurochem Int 112:59-70, 2018. DOI:10.1016/j.neuint - Hashimoto M, Yamanaka A, Kato S, Tanifuji M, Kobayashi K, Yaginuma H.
Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus.
Frontiers in Neural Circuit 12:6, 2018. DOI:10.3389/fncir.2018.00006 - Sobue A, Ito N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K.
Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes.
Glia 66:1034-1052, 2018. DOI:10.1002/glia.23299 - Kitamura T.
ASXL1 mutations gain a function.
Blood 131(3):274-275, 2018. DOI:10.1182/blood-2017-12-816595 - Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR.
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.
EMBO J., 2018. DOI:10.15252/embj.201797858 - Moriguchi S, Ishizuka T, Yabuki Y, Shioda N, Sasaki Y, Tagashira H, Yawo H, Yeh JZ, Sakagami H, Narahashi T, Fukunaga K.
Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy.
Mol Psychiatry. 23(2):211-221, 2018. DOI:10.1038/mp.2016.187 - Hayashida T, Saito Y, Ishii A, Yamada H, Itakura A, Minato T, Fukuyama T, Maegaki Y, Hirose S.
CACNA1A-related early-onset encephalopathy with myoclonic epilepsy: A case report.
Brain & Development 40(2):130-133, 2018. DOI:10.1016/j.braindev.2017.08.006 - Hashimoto K, Ochi H, Sunamura S, Kosaka N, Mabuchi Y, Fukuda T, Yao K, Kanda H, Ae K, Okawa A, Akazawa C, Ochiya T, Futakuchi M, Takeda S, Sato S
Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A.
Proc Natl Acad Sci U S A 115(9):2204-2209, 2018. DOI:10.1073/pnas.1717363115 - Mito M., Kadota M., Tanaka K., Furuta Y., Abe K., Iwasaki S.*, and Nakagawa S.
Cell-type specific survey of epigenetic modifications by tandem chromatin immunoprecipitation sequencing.
Scientific Reports 8:1143, 2018. DOI:10.1038/s41598-018-19494-9 - Nakamura, Y., Nakamura, K.
Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability.
Pfl?gers Archiv - European Journal of Physiology 470:823-837, 2018. DOI:10.1007/s00424-017-2090-z - Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, Nabeshima T.
Cerebellar α6 subunit-containing GABAA receptors: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders.
Br J Pharmacol. 175(12):2414-2427, 2018. DOI:10.1111/bph.14198 - Sakai E., Nakayama M., Oshima H., Kouyama Y., Niida A., Fujii S., Ochiai A., Nakayama KI., Mimori K., Suzuki Y., Hong CP., Ock CY., Kim SJ., Oshima M.
Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.
Cancer Res. 78(5):1334-1346, 2018. DOI:10.1158/0008-5472.CAN-17-3303 - Kaizuka T, Hayashi T
Comparative analysis of palmitoylation sites of serotonin (5-HT) receptors in vertebrates.
Neuropsychopharmacology Reports 38:75-85, 2018. DOI:10.1002/npr2.12011 - Hagihara H., Catts VS., Katayama Y., Shoji H., Takagi T., Huang FL., Nakao A., Mori Y., Huang KP., Ishii S., Graef IA., Nakayama KI., Shannon Weickert C., Miyakawa T.
Decreased brain pH as a shared endophenotype of psychiatric disorders.
Neuropsychopharmacology 43:459-68, 2018. DOI:10.1038/npp.2017.167 - *Fakruddin M, *Wei FY, Suzuki T, Asano K, Kaieda T, Omori A, Izumi R, Fujimura A, Kaitsuka T, Miyata K, Araki K, Oike Y, Scorrano L, Suzuki T, Tomizawa K.
Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
Cell Rep 22:482-496, 2018. - Nakayama S., Yumimoto K., Kawamura A., Nakayama KI.
Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7?in a manner dependent on the kinase GSK-3.
J. Biol. Chem. 293(15):5705-5714, 2018. DOI:10.1074/jbc.RA117.000741 - Eisuke Sato, Maho Morita, Haruo Ogawa, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Satoshi ?mura, Arihiro Iwasaki and Kiyotake Suenaga
Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ pump inhibitor from marine cyanobacteria.
Bioorganic & Medicinal Chemistry Letters 28 (3):298-301, 2018. DOI:10.1016/j.bmcl.2017.12.050 - Suda Y, Kuzumaki N, Narita M, Hamada Y, Shibasaki M, Tanaka K, Tamura H, Kawamura T, Kondo T,?Yamanaka A, *Narita M.
Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors.
Biochemical and Biophysical Research Communications? 496(4):1102-1108, 2018. DOI:10.1016/j.bbrc.2018.01.145 - Kusumoto Y, Okuyama H, Shibata T, Konno K, Takemoto Y, Maekawa D, Kononaga T, Ishii T, Akashi-Takamura S, Saitoh SI, Ikebuchi R, Moriya T, Ueda M, Miyake K, Ono S, Tomura M.
Epithelial Membrane Protein 3 (Emp3) Downregulates Induction and Function of Cytotoxic T Lymphocytes by Macrophages via TNF-α Production.
Cell Immunol. 30(2):43-51, 2018. DOI:10.1016/j.cellimm.2017.12.001 - Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, Fujii T, Kakuta S, Kubo S, Shibata T, Yamaguchi K, Iwakura Y, Furukawa Y.
Establishment and Analysis of a Novel Mouse Line Carrying a Conditional Knockin Allele of a Cancer-Specific FBXW7 Mutation.
Sci Rep. 8:2021, 2018. DOI:10.1038/s41598-018-19769-1 - Arakawa, H., & Iguchi, Y.
Ethological and multi-behavioral analysis of learning and memory performance in laboratory rodent models.
Neuroscience Research 135:1-12, 2018. DOI:10.1016/j.neures.2018.02.001 - Lucas BA, Lavi E, Shiue L, Cho H, Katzman S, Miyoshi K, Siomi MC, Carmel L, Ares M Jr, Maquat LE.
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A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling.
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A DNA Contact Map for the Mouse Runx1 Gene Identifies Novel Haematopoietic Enhancers.
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A novel mouse model of iNKT cell-deficiency generated by CRISPR/Cas9 reveals a pathogenic role of iNKT cells in metabolic disease.
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Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis.
Mol Brain 10(1):47, 2017. DOI:10.1186/s13041-017-0328-5 - Bayarsaikhan G, Miyakoda M, Yamamoto K, Kimura D, Akbari M, Yuda M and Yui K
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Alternative Formation of Red-Shifted Channelrhodopsins: Noncovalent Incorporation with Retinal-Based Enamine-Type Schiff Bases and Mutated Channelopsin.
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Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.
Osteoarthr Cartilage 26:108-117, 2017. DOI:10.1016/j.joca.2017.10.011 - Tanaka N, Mashima T, Mizutani A, Sato A, Aoyama A, Gong B, Yoshida H, Muramatsu Y, Nakata K, Matsuura M, Katayama R, Nagayama S, Fujita N, Sugimoto Y, Seimiya H.
APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.
Molecular Cancer Therapeutics 16(4):752-762, 2017. DOI:10.1158/1535-7163.MCT-16-0578 - Yamamoto, H., Sato, A., and Kikuchi, A.
Apical secretion of Wnt1 in polarized epithelial cells is regulated by exocyst-mediated trafficking.
J. Biochem. 162:317-326, 2017. DOI:10.1093/jb/mvx035 - Shimmyo N, Hishimoto A, Otsuka I, Okazaki S, Boku S, Mouri K, Horai T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
Association Study of MIF Promoter Polymorphisms With Suicide Completers in the Japanese Population.
Neuropsychiatr Dis Treat. 13:899-908, 2017. DOI:10.2147/NDT.S130855 - Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.
Autophagy 17:764-777, 2017. DOI:10.1080/15548627.2017.1314897 - Ishihara N, Suzuki S, Tanaka S, Watanabe Y, Nagayama D, Saiki A, Tanaka T, Tatsuno I.
Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells.
Mol Med Rep. 16(4):4756-4762, 2017. DOI:10.3892/mmr.2017.7141 - Kwon T*, Sakamoto M* (Co-first author), Peterka DS, Yuste R
Attenuation of Synaptic Potentials in Dendritc Spines.
Cell Reports 20(5):1100-1110, 2017. DOI:10.1016/j.celrep.2017.07.012 - Kuma A, Komatsu M, Mizushima N.
Autophagy-monitoring and autophagy-deficient mice.
Autophagy 13:1619-1628, 2017. DOI:10.1080/15548627.2017.1343770 - Sakagami H, Katsumata O, Hara Y, Sasaoka T, Fukaya M
BRAG2a, a guanine nucleotide exchange factor for Arf6, is a component of the dystrophin-associated glycoprotein complex at the photoreceptor terminal.
Investigative Ophthalmology and Visual Science (IOVS) 58 (9):3795-3803, 2017. DOI:10.1167/iovs.17-21746 - Morita N, Yamai I, Takahashi K, Kusumoto Y, Shibata T, Kobayashi T, Nonaka MI, Ichimonji I, Takagi H, Miyake K, Takamura SA
C4b Binding Protein Negatively Regulates TLR1/2 Response.
Innate Immun 23(1):11-19, 2017. DOI:10.1177/1753425916672312 - Shimizu T, Kamel WA, Yamaguchi-Iwai S, Fukuchi Y, Muto A, Saya H
Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response.
Cancer Science 108 (9):1793-1802, 2017. DOI:10.1111/Cas.13304 - Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H
Calmodulin kinases: essential regulators in health and disease.
Journal of neurochemistry 141(6):808-818, 2017. DOI:10.1111/jnc.14020 - Fakruddin M, Wei FY, Emura S, Matsuda S, Yasukawa T, Kang D, Tomizawa K.
Cdk5rap1-mediated 2-methylthio- N6- isopentenyl adenosine modification is absent from nuclear-derived RNA species.
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Cell Competition With Normal Epithelial Cells Promotes Apical Extrusion of Transformed Cells Through Metabolic Changes.
Nature Cell Biology 19(5):530-541, 2017. DOI:10.1038/ncb3509 - Okumura K, Kagawa N, Saito M, Yoshizawa Y, Munakata H, Isogai E, Fukagawa T and Wakabayashi Y.
CENP-R acts bilaterally as a tumor suppressor and an oncogene in the two-stage skin carcinogenesis model.
Cancer Science 108(11):2142-2148, 2017. DOI:10.1111/cas.13348 - Okumura K, Kagawa N, Saito M, Yoshizawa Y, Munakata H, Isogai E, Fukagawa T, and Wakabayashi Y.
CENP-R acts bilaterally as a tumor suppressor and an oncogene in the two-stage skin carcinogenesis model.
Cancer Science 108(11):2142-2148, 2017. - Shinji Nakamura, Walker DW, Wong FY
Cerebral haemodynamic response to somatosensory stimulation in fetal sheep.
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Cerebral haemodynamic response to somatosensory stimulation in neonatal lambs.
Journal of Physiology 595(17):6007-21, 2017. DOI:10.1113/JP274244 - Black SW,?Yamanaka A,?*Kilduff TS
Challenges in the development of therapeutics for narcolepsy.
Progress in Neurobiology 152:89-113, 2017. DOI:10.1016/j.pneurobio.2015.12.002 - Urai M, Aizawa T, Imamura K, Hamamoto H, Sekimizu K
Characterization of the chemical structure and innate immune-stimulating activity of an extracellular polysaccharide from?Rhizobium?sp. strain M2 screened using a silkworm muscle contraction assay.
Drug discoveries & therapeutics 11 (5):238-245, 2017. DOI:10.5582/ddt.2017.01045 - Okuno H, Renault Mihara F, Ohta S, Fukuda K, Kurosawa K, Akamatsu W, Sanosaka T, Kohyama J, Hayashi K, Nakajima K, Takahashi T, Wysocka J, Kosaki K, Okano H.
CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations.
Elife 6:e21114, 2017. DOI:10.7554/eLife.21114 - Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, *Igarashi M, *Sugiyama S
Chondroitin sulfate is required for onset and offset of critical period plasticity in visual cortex.
Sci Rep 7:12646-, 2017. DOI:10.1038/s41598-017-04007-x - Hashimoto Y, Fukasawa M, Kuniyasu H, Yagi K, Kondoh M
Claudin-targeted drug development using anti-claudin monoclonal antibodies to treat hepatitis and cancer.
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Comparison of the Upper Marginal Neurons of Cortical Layer 2 with Layer 2/3 Pyramidal Neurons in Mouse Temporal Cortex. .
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Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice.
Frontiers in Behavioral Neuroscience 11:125, 2017. DOI:10.3389/fnbeh - Hayashi T
Conservation and phylogenetic stepwise changes of aquaporin (AQP) 4 palmitoylation in vertebrate evolution.
Neurotransmitter 4:e1608, 2017. DOI:10.14800/nt.1608 - Watanabe T, Shimazaki T, Oda Y.
Coordinated expression of two types of low-threshold K+ channels establishes unique single-spiking of Mauthner cells among segmentally homologous neurons in the zebrafish hindbrain.
eNeuro 1523:0249-17, 2017. DOI:10.1523/ENEURO.0249-17.2017 - Fukutomi, M. and Ogawa, H.
Crickets alter wind-elicited escape strategies depending on acoustic context.
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Nat Commun. 8:1177, 2017. DOI:10.1038/s41467-017-01311-y - Aoto Y, Hachiya T, Okumura K, Hase S, Sato K, Wakabayashi Y, and Sakakibara Y.
DEclust: A statistical approach for obtaining differential expression profiles of multiple conditions.
PLoS ONE 12(11):e0188285, 2017. DOI:10.1371/journal.pone.0188285 - Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H.
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Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior.
The Journal of Experiment Medicine 214(5):1431-1452, 2017. DOI:10.1084/jem - Takano, T., Motozono, C*., Imai, T., Sonoda, KH., Nakanishi, Y., Yamasaki, S*.
Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity.
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Depletion of Myeloid Cells Exacerbates Hepatitis and Induces an Aberrant Increase in Histone H3 in Mouse Serum.
Hepatology 65(1):237-252, 2017. DOI:10.1002/hep.28878 - Tsutomu Fukuda, Teppei Umeki, Keiji Tokushima, Gao Xiang, Yuki Yoshida, Fumito Ishibashi, Yusuke Oku, Naoyuki Nishiya, Yoshimasa Uehara, Masatomo Iwao
Design, synthesis, and evaluation of A-ring-modified lamellarin N analogues as noncovalent inhibitors of the EGFR T790M/L858R mutant.
Bioorganic and Medicinal Chemistry 25 (24):6563-6580, 2017. DOI:10.1016/j.bmc.2017.10.030 - Syuji Kurogi, Tomohisa Sekimoto, Taro Funamoto, Tomomi Ota, Shihoko Nakamura, Takuya Nagai, Mai Nakahara, Kumiko Yoshinobu, Kimi Araki, Masatake Araki and Etsuo Chosa
Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
Sci. Rep. 7:40692, 2017. DOI:10.1038/srep40692 - Kumamoto K, Iguchi T, Ishida R, Uemura T, Sato M, Hirotsune S.
Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning.
Biol Open. 15:1041-1055, 2017. DOI:10.1242/bio.025999 - Kikuchi A., Fumoto K., Kimura H.
Dickkopf1-cytoskeleton-associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy.
Br. J. Pharmacol 174(24):4651-4665, 2017. DOI:10.1111/bph.13863 - Okubo T, Sato A, Okamoto H, Sato T, Sasaoka T
Differential behavioral phenotypes of dopamine D1 receptor knockdown mice at the embryonic, postnatal, and adult stages.
International Journal of Developmental Neuroscience 66:1-8, 2017. DOI:10.1016/j.ijdevneu.2017.11.004 - Zankov DP, Sato A, Shimizu A, Ogita H.
Differential effects of myocardial afadin on pressure overload-induced compensated cardiac hypertrophy.
Circ J 81:1862-1870, 2017. DOI:10.1253/circj.CJ-17-0394 - Jiang F-X, Li K, Archer M, Mehta M, Jamieson E, Charles A, Dickinson JE, Matsumoto M, Morahan G
Differentiation of Islet Progenitors Regulated by Nicotinamide into Transcriptome-verified β Cells that Ameliorate Diabetes.
Stem Cells 35:1341-1354, 2017. DOI:10.1002/stem.2567 - Yasuda D, Yuasa A, Obata R, Nakajima M, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.
Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor.
Bioorg Med Chem Lett. 27:5006-5009, 2017. DOI:10.1016/j.bmcl.2017.10.008 - Ueda Y, Yamanaka K, Noritake A, Enomoto K, Matsumoto N, Yamada H, Samejima K, Inokawa H, Hori Y, Nakamura K, Kimura M.
Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection.
Frontiers in Neuroanatomy 0.504166666666667, 2017. DOI:10.3389/fnana.2017.00066 - Soma S, Saiki A, Yoshida J, R?os A, Kawabata M, Sakai Y, Isomura Y
Distinct laterality in forelimb-movement representations of rat primary and secondary motor cortical neurons with intratelencephalic and pyramidal tract projections.
The Journal of Neuroscience 37(45):10904-10916, 2017. DOI:10.1523/JNEUROSCI.1188-17.2017 - M. Ishido*, R.Usu
Distinct regulation of nuclear localization of caspase-activated DNase during cadmium-induced apoptosis of the target cells.
Fund. Toxicol. Sci. 4:159-165, 2017. DOI:10.2131/fts.4.159 - Ide S, Takahashi T, Takamatsu Y, Uhl GR, Niki H, Sora I, Ikeda K.
Distinct Roles of Opioid and Dopamine Systems in Lateral Hypothalamic Intracranial Self-Stimulation.
Int J Neuropsychopharmacol. 20(5):403-409, 2017. DOI:10.1093/ijnp/pyw113 - Shindou H, Koso H, Sasaki J, Nakanishi H, Sagara H, Nakagawa KM, Takahashi Y, Hishikawa D, Iizuka-Hishikawa Y, Tokumasu F, Noguchi H, Watanabe S, Sasaki T, Shimizu T
Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells.
J. Biol. Chem 292(29):12054-12064, 2017. DOI:10.1074/jbc.M117.790568 - Yamaguchi N, Nakayama Y, Yamaguchi N
Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6.
J Biol Chem. 292(20):8136-8148, 2017. DOI:10.1074/jbc.M116.763276 - Kanki Y, Nakaki R, Shimamura T, Matsunaga T, Yamamizu K, Katayama S, Suehiro J, Osawa T et al.
Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation.
Nucleic Acids Research 45(8):4344-4358, 2017. - Nakamoto K, Aizawa F, Miyagi K, Yamashita T, Mankura M, Koyama Y, Kasuya F, Hirasawa A, Kurihara T, Miyata A, Tokuyama S.
Dysfunctional GPR40/FFAR1 Signaling Exacerbates Pain Behavior in Mice.
PLoS One 12(7):e0180610, 2017. DOI:10.1371/journal.pone.0180610 - Yuichiro Yoneoka, Masayasu Okada, Naoto Watanabe, Satoru Aoki, Akiyoshi Kakita, Yukihiko Fujii
Ectopic pituitary null cell adenoma arising from the infundibulum in the third ventricle: A successful endonasal transsphenoidal resection after long-term follow-up MR imaging ? A technical note.
Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 10:122-125, 2017. DOI:10.1016/j.inat.2017.08.004 - Masatsugu Ohgami, Nobuhiko Takai, Masahiko Watanabe, Koichi Ando, Akiko Uzawa, Ryoichi Hirayama
EFFECT OF N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST ON RADIATION-INDUCED GUT INJURIES IN MICE.
RadProc vol.2, 2017. DOI:10.21175 - Ohta Y, Kubo H, Yashiro K, Ohashi K, Tsuzuki Y, Wada N, Yamamoto Y, Saito K.
Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues.
J Physiol Sci. 67:361-372, 2017. DOI:10.1007/s12576-016-0467-y - Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T, Kuniyasu H
Elaidic acid, a trans fatty acid, enhances the metastasis of colorectal cancer cells.
Pathobiology 84(3):144-151, 2017. DOI:10.1159/000449205 - Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabe M, Sasahara M, Fukunaga K
Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons.
Molecular Psychiatry 22 (8):1205-1222, 2017. DOI:10.1038/mp.2016.200 - Hattori M, Shimizu A, Oikawa D, Kamei K, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Tokunaga F, Ishikawa O.
Endoplasmic reticulum stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa.
British Journal of Dermatology 177(4):e92-e93, 2017. DOI:10.1111/bjd.15342 - Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama, Kentaro semba, Takuya Tomita, Shigeo Murata, Hiroyuki Arai and Tomohiko Taguchi
Endosomal phosphatdylserine is critical for the YAP signaling pathway in proliferating cells.
Nature Communications 8:1246, 2017. DOI:10.1038/s41467-017-01255-3 - Goswami, D., Marz, S., Li, Y. T., Artz, A., Schafer, K., Seelige, R., Pacheco-Blanco, M., Jing, D., Bixel, M. G., Araki, M., Araki, K., Yamamura, K., Vestweber, D.
Endothelial CD99 supports arrest of mouse neutrophils in venules and binds to neutrophil PILRs.
Blood 129(13):1811-1822, 2017. DOI:10.1182/blood-2016-08-733394 - Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N
Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).
Biochem Biophys Res Commun. 490(3):1045-1051, 2017. DOI:10.1016/j.bbrc.2017.06.163 - Goyama S and Kitamura T.
Epigenetics in Normal and Malignant Hematopoiesis: An Overview and Update 2017.
Cancer Sci. 108(4):553-562, 2017. DOI:10.1111/cas.13168 - Shinohara K., Watabe, A.M. #, Nagase M., Okutsu Y., Takahashi Y., Kurihara H., Kato F.(#責任著者)
Essential Role of Endogenous Calcitonin Gene-Related Peptide in Pain-associated Plasticity in the Central Amygdala.
European Journal of Neuroscience 46(6):2149-2160, 2017. DOI:10.1111/ejn.13662 - Muto Y., Nishiyama M., Nita A., Moroishi T., Nakayama KI.
Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
Nature Commun. 8:16114, 2017. DOI:10.1038/ncomms16114 - Kondo A & Osawa T
Establishment of an extracellular acidic pH culture system.
JoVE 129:e56660, 2017. - Itoh M, Kaizuka T, Hayashi T
Evolutionary acquisition and divergence of vertebrate HCN2 palmitoylation.
Neurotransmitter 4:e1603, 2017. DOI:10.14800/nt.1603 - Yanase T, Matsumoto M, Tanaka T, Mera T, Yasunami Y, Daibo K
Expansion of transplanted islets in mice by co-transplantation with adipose tissue-derived mesenchymal stem cells.
Heliyon :e00632, 2017. DOI:10.1016/j.heliyon.2018.e00632 - Huang M, Narita S, Inoue T, Koizumi A, Saito M, Tsuruta H, Numakura K, Satoh S, Nanjo H, Sasaki T, Habuchi T
Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production.
Oncotarget 8(67):111780-111794, 2017. DOI:10.18632/oncotarget.22908 - Kawahara I, Mori T, Goto K, Fujii K, Ohmori H, Fujiwara-Tani R, Kuniyasu H
Fatty acids induce stemness in the stromal cells of a CT26 mouse tumor model.
Pathobiology 84(5):237-242, 2017. DOI:10.1159/000471854 - Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Fujiwara R, Kadochi Y, Mori S, Kuniyasu H
Fatty acids inhibit anti-cancer effect of 5-fluorouracil in mouse cancer cell lines.
Oncology Letters 14(1):681-686, 2017. DOI:10.3892/ol.2017.6190 - Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon S, Fulda S, Gascon S, Hatzios SK, Kagan V, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat G, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti F, Torti S, Toyokuni S, Woerpel KA, Zhang DD.
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease.
Cell 171:273-285, 2017. DOI:10.1016/j.cell.2017.09.021 - Suzuki-Kerr H, Baba Y, Tsuhako A, Koso H, Dekker JD, Tucker H, Kuribayashi H, Watanabe S.
Forkhead box protein P1 is essential for lens epithelium transition to the fiber cells during development but does not play roles for retinal development.
Invest. Ophthalmol. Vis. Sci. 58:1916-1929, 2017. DOI:10.1167/iovs.16-20085 - Anzai E, Hirata K, Shibazaki M, Yamada C, Morii M, Honda T, Yamaguchi N, Yamaguchi N
FOXA1 Induces E-Cadherin Expression at the Protein Level via Suppression of Slug in Epithelial Breast Cancer Cells.
Biol Pharm Bull. 40(9):1483-1489, 2017. DOI:10.1248/bpb.b17-00307 - Saito K, Ohta S, Kawakami Y, Yoshida K, Toda M
Functional analysis of KIF20A, a potential immunotherapeutic target for glioma.
J Neurooncol 132(1):63-74, 2017. DOI:10.1007/s11060-016-2360-1 - Tsunoda SP, Prigge M, Abe-Yoshizumi R, Inoue K, Kozaki Y, Ishizuka T, Yawo H, Yizhar O, Kandori H.
Functional characterization of sodium-pumping rhodopsins with different pumping properties.
PLoS One. 12(7):e0179232, 2017. DOI:10.1371/journal.pone.0179232 - Ali MAE， Fuse K， Tadokoro Y， Hoshii T， Ueno M， Kobayashi M， Nomura N， Vu HT， Peng H， Hegazy AM， Masuko M， Sone H， Arai F， Tajima A， Hirao A.
Functional Dissection of Hematopoietic Stem Cell Populations With a Stemness-Monitoring System Based on NS-GFP Transgene Expression.
Scientific Report 7:11442, 2017. DOI:10.1038/s41598-017-11909-3 - Sato M, Kokabu S, Enoki Y, Hayashi N, Matsumoto M, Nakahira M, Sugasawa M, Yoda T
Functional roles of netrin-1 in osteoblast differentiation.
In vivo 31(3):321-8, 2017. - Ostrovidov S, Ebrahimi M, Bae H, Nguyen HK, Salehi S, Kim SB, Kumatani A, Matsue T, Shi X, Nakajima K, Hidema S, Osanai M, Khademhosseini A
Gelatin-Polyaniline Composite Nanofibers Enhanced Excitation-Contraction Coupling System Maturation in Myotubes.
ACS Applied Materials & Interfaces 9(49):42444-42458, 2017. DOI:10.1021/acsami.7b03979 - Nishihara S
Glycans define the stemness of na?ve and primed pluripotent stem cells.
Glycoconj J. 34(6):737-747, 2017. DOI:10.1007/s10719-016-9740-9 - Okamoto A, Morinaga T, Yamaguchi N, Yamaguchi N
Golgi Distribution of Lyn to Caveolin- and Giantin-Positive cis-Golgi Membranes and the Caveolin-Negative, TGN46-Positive trans-Golgi Network.
Biol Pharm Bull.? 41(1):142-146, 2017. DOI:10.1248/bpb.b17-00681 - Shuji Wakatsuki, Shinji Tokunaga, Megumi Shibata,Toshiyuki Araki
GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration.
J Cell Biology 216:477, 493, 2017. DOI:10.1083/jcb.201606020 - Hasumi H, Hasumi Y, Baba M, Nishi H, Furuya M, Vocke CD, Warner AC, Haines DC, Wei MH, Zbar B, Yao M, Metwalli AR, Marston Linehan W, Schmidt LS.
H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.
Human Molecular Genetics 26(2):354-366, 2017. DOI:10.1093/hmg/ddw392 - Hideko Ohno, Yuichiro Yoneoka, Shinya Jinguji, Naoto Watanabe, Masayasu Okada, Yukihiko Fujii
Has acromegaly been diagnosed earlier?.
Journal of Clinical Neuroscience 48:138-142, 2017. DOI:10.1016/j.jocn.2017.10.086 - Zhang S., Chen Q., Liu Q., Li Y., Sun X., Hong L., Ji S., Liu C., Geng J., Zhang W., Lu Z., Yin ZY., Zeng Y., Lin KH., Wu Q., Li Q., Nakayama K., Nakayama KI., Deng X., Johnson RL., Zhu L., Gao D., Chen L., Zhou D.
Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2.
Cancer Cell 31:669-84, 2017. DOI:10.1016/j.ccell.2017.04.004 - M. Ishido*, R.Usu
HSP70-Ran-RCC1 transport system during cadmium-induced apoptosis in porcine kidney LLC-PK1 cells.
Fund. Toxicol. Sci. 4:187-189, 2017. DOI:10.2131/fts.4.187 - Goto A, Yoshimi A, Nagai T, Ukigai M, Mouri A, Ozaki N, Noda Y.
Human neutrophils show decreased survival upon long-term exposure to clozapine.
Hum Psychopharmacol. 32:e2629, 2017. DOI:10.1002/hup.2629 - Ono D, Yamanaka A
Hypothalamic regulation of the sleep/wake cycle.
Neuroscience Research 118:74-81, 2017. DOI:10.1016/j.neures.2017.03.013 - Sato Y, Tsuyama T, Sato C, Karim MF, Yoshizawa T, Inoue M, Yamagata K
Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase.
J Biol. Chem. 292:8716-8728, 2017. DOI:10.1074/jbc.M116.767574 - Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A.
Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.
Leukemia 31(4):861-871, 2017. DOI:10.1038/leu.2016.268 - Tsukada M, Ota Y, Wilkinson AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S.
In?Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma.
Stem Cell Reports. 9(4):1024-1033, 2017. DOI:10.1016/j.stemcr.2017.08.010 - Kimura A, Takemura M, Saito K, Serrero G, Yoshikura N, Hayashi Y, Inuzuka T.
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Individual differences are consistent across changes in mating status and mediated by biogenic amine.
Behav. Ecol. Sociobiol. 71:118, 2017. DOI:10.1007/s00265-017-2345-x - Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S.
Iron and thiol redox signaling in cancer.
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Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes.
Cell & Tissue Research 370(3):441-449, 2017. DOI:10.1007/s00441-017-2674-0 - Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
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The Journal of Physiology 595(1):385-413, 2017. DOI:10.1113/JP272794 - Yamashita T, *Yamanaka A
Lateral hypothalamic circuits for sleep-wake control.
Current Opinion in Neurobiology 44:94-100, 2017. DOI:10.1016/j.conb.2017.03.020 - Yamamoto, H., Umeda, D., Matsumoto, S., and Kikuchi, A.
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JCI Insight 2:e90903, 2017. DOI:10.1172/jci.insight.90903 - van Wijk SJL, Fricke F, Herhaus L, Gupta J, H?tte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I.
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Sci Rep. 7, 2017. DOI:10.1038/s41598-017-15305-9 - Kondo A, Nonaka A, Shimamura T, Yamamoto S, Yoshida T, Kodama T, Aburatani H and Osawa T
Long non-coding RNA JHDM1D-AS1 promotes tumor growth by regulating angiogenesis in response to nutrient starvation.
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Loss of Synapse Repressor MDGA1 Enhances Perisomatic Inhibition, Confers Resistance to Network Excitation, and Impairs Cognitive Function.
Cell Rep. 21:3637-3645, 2017. DOI:10.1016/j.celrep.2017.11.109 - Hanaki, Y., Kikumori, M., Tokuda, H., Okamura, M., Dan, S., Adachi, N., Saito, N., Yanagita, R. C., Irie, K.
Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities.
Molecules 22(4):e631, 2017. DOI:10.3390/molecules22040631 - Hashimotodani, Y., Nasrallah, K., Jensen, K.R., Chavez, A.E., Carrera, D., and Castillo, P.E.
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Neuron 95:928-943, 2017. DOI:10.1016/j.neuron.2017.07.028 - Iizuka-Hishikawa Y, Hishikawa D, Sasaki J, Takubo K, Goto M, Nagata K, Nakanishi H, Shindou H, Okamura T, Ito C, Toshimori K, Sasaki T, Shimizu T.
Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis.
J Biol Chem. 292:12065-12076, 2017. DOI:10.1074/jbc.M117.791277 - Fuse MJ, Okada K, Oh-hara T, Ogura H, Fujita N, *Katayama R.
Mechanisms of resistance to NTRK inhibitors and therapeutic strategies in NTRK1-rearranged cancers.
Molecular Cancer Therapeutics 16:2130-2143, 2017. DOI:10.1158/1535-7163.MCT-16-0909 - Yamamoto K, Mak TW
Mechanistic aspects of mammalian cell size control.
Development Growth and Differentiation 59(1):33-40, 2017. DOI:10.1111/dgd.12334 - Yamamoto S., Hagihara T., Horiuchi H., Okui A., Wani S., Yoshida T., Inoue T., Tanaka A., Ito T., Hirose Y., and Ohkuma Y.
Mediator Cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.
Genes to Cells 22(3):265-276, 2017. DOI:10.1111/gtc.12475 - Yoshida A, Kitajima S, Li F, Cheng C, Takegami Y, Kohno S, Wan YS, Hayashi N, Muranaka H, Nishimoto Y, Nagatani N, Nishiuchi T, Thai TC, Suzuki S, Nakao S, Tanaka T, Hirose O, Barbie DA, Takahashi C.
MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6.
Oncotarget 8(8):13872-13885, 2017. DOI:10.18632/oncotarget.14681 - Tanaka K, Kim SE, Yano H, Matsumoto G, Ohuchida R, Ishikura Y, Araki M, Araki K, Park S, Komatsu T, Hayashi H, Ikematsu K, Tanaka K, Hirano A, Martin P, Shimokawa I, Mori R
MiR-142 Is Required for Staphylococcus aureus Clearance at Skin Wound Sites via Small GTPase-Mediated Regulation of the Neutrophil Actin Cytoskeleton.
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Mitochondrial uncoupler exerts a synthetic lethal effect against beta-catenin mutant tumor cells.
Cancer Science 108:772-784, 2017. DOI:10.1111/cas.13172 - Fumoto, K., Takigawa-Imamura, H., Sumiyama, K., Kaneiwa, T., and Kikuchi, A.
Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition.
Development 144:151-162, 2017. DOI:10.1242/dev.141325 - Mashima T, Taneda Y, Jang MK, Mizutani A, Muramatsu Y, Yoshida H, Sato A, Tanaka N, Sugimoto Y, Seimiya H.
mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer.
Oncotarget 8(29):47902-47915, 2017. DOI:10.18632/oncotarget.18146 - Sashida G, Iwama A.
Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies.
Int J Hematol 105(1):23-30, 2017. DOI:10.1007/s12185-016-2124-x - Takiguchi T, Koide H, Nagano H, Nakayama A, Fujimoto M, Tamura A, Komai E, Shiga A, Kono T, Higuchi S, Sakuma I, Hashimoto N, Suzuki S, Miyabayashi Y, Ishiwatari N, Horiguchi K, Nakatani Y, Yokote K, Tanaka T.
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
BMC Endocr Disord. 17(1):54-61, 2017. DOI:10.1186/s12902-017-0203-5 - Umeda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, Tomiyama T
Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.
Acta Neuropathol Commun 31:5(1):59, 2017. DOI:10.1186/s40478-017-0461-5 - Asano T, Ishizuka T, Yawo H.
Myogenic Maturation by Optical-Training in Cultured Skeletal Muscle Cells.
Methods Mol Biol. 1668:135-145, 2017. DOI:10.1007/978-1-4939-7283-8_10 - M. Ishido*, J. Suzuki, Y. Masuo
Neonatal rotenone lesions cause onset hyperactivity during juvenile and adulthood in the rat.
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Netrin-4 Promotes Differentiation and Migration of Osteoblasts.
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Neurocognitive Profile of Euthymic Japanese Patients With Bipolar Disorder.
Psychiatry Clin Neurosci. 71(6):373-382, 2017. DOI:10.1111/pcn.12500 - Yuji Sato, Satoko Suzuki, Yoko Iijima, and Takatoshi Iijima.
Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of Neurexin in cerebellar cultures.
Biochemical and Biophysical Research Communications. 493:1030-1036, 2017. DOI:10.1038/s41598-017-11319-5 - Nakatsumi H., Matsumoto M., Nakayama KI.
Noncanonical pathway for regulation of CCL2 expression by an mTORC1-FOXK1 axis promotes recruitment of tumor-associated macrophages.
Cell Rep. 21:2471-86, 2017. DOI:10.1016/j.celrep.2017.11.014 - Fukushima H., Shimizu K., Watahiki A., Hoshikawa S., Kosho T., Oba D., Sakano S., Arakaki M., Yamada A., Nagashima K., Okabe K., Fukumoto S., Jimi E., Bigas A., Nakayama KI., Nakayama K., Aoki Y., Wei W., Inuzuka H.
NOTCH2 Hajdu-Cheney mutations escape SCFFBW7-dependent proteolysis to promote osteoporosis.
Mol. Cell 68:645-58.e5, 2017. DOI:10.1016/j.molcel.2017.10.018 - Kim TS, Shin YH, Lee HM, Kim JK, Choe JH, Jang JC, Um S, Jin HS, Komatsu M, Cha GH, Chae HJ, Oh DC, Jo EK.
Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway.
Sci Rep. 7, 2017. DOI:10.1038/s41598-017-03477-3 - Yamaki N, Hishimoto A, Otsuka I, Sasada T, Boku S, Saito T, Yasuda Y, Yamamori H, Ikeda M, Sora I, Iwata N, Hashimoto R
Optimizing Outcomes in Clozapine Rechallenge Following Neutropenia Using Human Leukocyte Antigen Typing: A Case Report.
Psychiatry Clin Neurosci 71(4):289-290, 2017. DOI:10.1111/pcn.12505 - Ozaki M, Sano H, Sato S, Ogura M, Mushiake H, Chiken S, Nakano N, Nambu A
Optogenetic activation of the sensorimotor cortex reveals “local inhibitory and global excitatory” inputs to the basal ganglia.
Cerebral cortex 27:5716-5726, 2017. DOI:10.1093/cercor/bhx234 - Abe K, Yawo H.
Optogenetic conditioning of paradigm and pattern discrimination in the rat somatosensory system.
PLoS One 12(12):e0189439, 2017. DOI:10.1371/journal.pone.0189439 - Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, *Mendelowitz D
Optogenetic identification of hypothalamic orexin neuron projections to paraventricular spinally projecting neurons.
American journal of physiology. Heart and circulatory physiology 312(4):H808-H817, 2017. DOI:10.1152/ajpheart.00572.2016 - M. Ishido*, R.Usu
Orally administered p-nitrotoluene causes hyperactivity, concomitant with gliosis and impairment of tyrosine hydroxylase immunoreactivity in the rat substantia nigra.
Fund. Toxicol. Sci. 4:151-158, 2017. DOI:10.2131/fts.4.151 - Mukai S, Oue N, Oshima T, Imai T, Sekino Y, Honma R, Sakamoto N, Sentani K, Kuniyasu H, Egi H, Tanabe K, Yoshida K, Ohdan H, Yasui W
Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer.
Journal of Pathology 243(1):100-110, 2017. DOI:10.1002/path.4931 - Yokose, J., Okubo-Suzuki, R., Nomoto, M., Ohkawa, N., Nishizono, H., Suzuki, A., Matsuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A.M., Sasahara, M., Kato, F., Inokuchi, K.
Overlapping memory trace indispensable for linking, but not recalling, individual memories.
Science 355(6323):398-403, 2017. DOI:10.1126/science.aal2690 - Nasanbuyan N, Yoshida M, Takayanagi Y, Inutsuka A, Nishimori K, Yamanaka A, *Onaka T.
Oxytocin-Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice.
Endocrinology. 159(2)::763-775, 2017. DOI:10.1210/en.2017-00606 - Nakamura K, Ding L
Parsing Heterogeneous Striatal Activity.
Frontiers in neuroanatomy 0.488194444444444, 2017. DOI:10.3389/fnana.2017.00043 - Sato A, Ogita H.
Pathophysiological Implications of Dipeptidyl Peptidases.
Curr Protein Pept Sci 18:843-849, 2017. DOI:10.2174/1389203718666170329104936 - Yuichiro Yoneoka, Junichi Yoshimura, Masayasu Okada, Yukihiko Fujii:
Perifocal Inflammatory Reaction with Volume Fluctuation Caused by Diagnostic Radiation-Induced Reduction in Germinoma Makes Histological Diagnosis Difficult despite Its Disappearance following Treatment: A Significant Pitfall and Countermeasures to It.
Pediatr Neurosurg. 52:87-92, 2017. DOI:10.1159/000450583 - Naoaki Sakata, Yohko Yamaguchi, Yu Chen, Masayuki Shimoda, Gumpei Yoshimatsu, Michiaki Unno, Shoichiro Sumi, Rieko Ohki.
Pleckstrin homology-like domain family A, member 3 (PHLDA3) deficiency improves islets engraftment through the suppression of hypoxic damage.
PLoS One 12(11):e0187927, 2017. DOI:10.1371/journal.pone.0187927 - Sato N, Shidara H, Ogawa H.
Post-molting development of wind-elicited escape behavior in the cricket.
J Insect Physiol. 103:36-46, 2017. DOI:10.1016/j.jinsphys.2017.10.003 - Fujii K, Luo Y, Nishiguchi Y, Fujiwara R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H
Pro-metastatic intracellular signaling of elaidic acid, a trans fatty acid.
Int J Oncol 50(1):85-92, 2017. DOI:10.3892/ijo.2016.3797 - Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A
Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory-functions and neurogenesis.
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Proton pump inhibitor induces-collagen expression in colonocytes is associated with collagenous colitis.
World Journal of Gastroentrology 23(9):1586-1593, 2017. DOI:10.3748/wjg.v23.i9.1586 - Kuramitsu M, Sekizuka T, Yamochi T, Firouzi S, Sato T, Umeki K, Sasaki D, Hasegawa H, Kubota R, Sobata R, Matsumoto C, Kaneko N, Momose H, Araki K, Saito M, Nosaka K, Utsunomiya A, Koh KR, Ogata M, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, Okayama A, Miura K, Satake M, Saito S, Itabashi K, Yamaguchi K, Kuroda M, Watanabe T, Okuma K, Hamaguchi I.
Proviral Features of Human T Cell Leukemia Virus Type 1 in Carriers with Indeterminate Western Blot Analysis Results.
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PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.
Mol Cell 68(3):566-580, 2017. DOI:10.1016/j.molcel.2017.09.024 - Koike M, Shibata M, Sunabori T, Yamaguchi J, Sakimura K, Komatsu M, Tanaka K, Uchiyama Y.
Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.
Am J Pathol. 187:1586-1600, 2017. DOI:10.1016/j.ajpath.2017.02.020 - Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Inoue E, Igeta H, Otsuka I, Shibuya M, Egawa J, Sora I, Someya T.
Rare FBXO18 Variations and Risk of Schizophrenia: Whole-exome Sequencing in Two Parent-Affected Offspring Trios Followed by Resequencing and Case-Control Studies.
Psychiatry Clin Neurosci. 71(8):562-568, 2017. DOI:10.1111/pcn.12526. - Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Kaneko N, Muratake T, Shinmyo N, Otsuka I, Okuda S, Inoue E, Igeta H, Shibuya M, Egawa J, Orime N, Sora I, Someya T.
Rare PDCD11 Variations Are Not Associated With Risk of Schizophrenia in Japan.
Psychiatry Clin Neurosci 71(11):780-788, 2017. DOI:10.1111/pcn.12549 - Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.
Nucleic Acids Res. 45:435-445, 2017. DOI:10.1093/nar/gkw745 - Moriguchi S, Kita S, Fukaya M, Osanai M, Inagaki R, Sasaki Y, Izumi H, Horie K, Takeda J, Saito T, Sakagami H, Saido TC, Iwamoto T, Fukunaga K
Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.
Neuropharmacology 131:291-303, 2017. DOI:10.1016/j.neuropharm.2017.12.037 - Fukai Y, Ohsawa Y, Ohtsubo H, Nishimatsu S, Hagiwara H, Noda M, Sasaoka T, Murakami T, Sunada Y
Redundancy of matrix metalloproteinases cleaving beta-dystroglycan: Implications for the pathogenesis of sarcoglycanopathy.
Biochemical Biophysical Research Communications 492 (2):199-205, 2017. DOI:10.1016/j.bbrc.2017.08.048 - Katow H, Kanaya T, Ogawa T, Egawa R, Yawo H.
Regulation of axon arborization pattern in the developing chick ciliary ganglion: Possible involvement of caspase 3.
Dev Growth Differ. 59(3):115-128. 2017 59(3):115-128, 2017. DOI:10.1111/dgd.12346 - Kadochi Y, Mori S, Fujiwara-Tani R, Luo Y, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed proliferation of CT26 mouse colon cancer cells.
Oncology Letters 14(1):673-680, 2017. DOI:10.3892/ol.2017.6195 - *Tamada A, Igarashi M
Revealing chiral cell motility by 3D Riesz transform-differential interference contrast microscopy and computational kinematic analysis.
Nature Communications 8:2194ｰ, 2017. DOI:10.1038/s41467-017-02193-w - Kuroda N, Ohe C, Kato I, Furuya M, Baba M, Nagashima Y, Nakatani Y, Murakami I, Zhou M, Michal M, He O, Amin MB
Review of hereditary leiomyomatosis renal cell carcinoma with focus on clinical and pathobiological aspects of renal tumors.
Polish Journal of Pathology 68(4):284-296, 2017. DOI:10.5114/pjp.2017.73920 - Ito S, Koso H, Sakamoto K, Watanabe S
RNA helicase DHX15 acts as a tumour suppressor in glioma.
Br. J. Cancer 117(9):1349-1359, 2017. DOI:10.1038/bjc.2017.273 - K Nakayama, R Ohashi, Y Shinoda, M Yamazaki, M Abe, A Fujikawa, S Shigenobu, A Futatsugi, M Noda, K Mikoshiba, T Furuichi, K Sakimura, and N Shiina
RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation.
eLife 6:e29677, 2017. DOI:10.7554/eLife.29677 - Yachie N., Robotic Biology Consortium (incl. Nakayama KI.), Natsume T.
Robotic crowd biology with Maholo LabDroids.
Nature Biotechnol. 35:310-2, 2017. DOI:10.1038/nbt.3758 - Honda A, Usui H, Sakimura K, *Igarashi M
Rufy3 is an adapter protein for small GTPases that activates a Rac guanine nucleotide exchange factor to control neuronal polarity.
J Biol Chem 292:20936-20946, 2017. DOI:10.1074/jbc.M117.809541 - Wang CQ, Mok MM, Yokomizo T, Tergaonkar V, Osato M.
Runx Family Genes in Tissue Stem Cell Dynamics.
Adv Exp Med Biol 962(-):117-138, 2017. DOI:10.1007/978-981-10-3233-2_9 - Selvarajan V, Osato M, Nah GSS, Yan J, Chung TH, Voon DC, Ito Y, Ham MF, Salto-Tellez M, Shimizu N, Choo SN, Fan S, Chng WJ, Ng SB.
RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC.
Leukemia 31(10):2219-2227, 2017. DOI:10.1038/leu.2017.40 - T. Watanabe, Y. Mutoh, S. Saito
Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylanilides: Synthesis of 3-Substituted Indoles by 1,2-Carbon Migration.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139:7749-7752, 2017. DOI:10.1021/jacs.7b04564 - Kubo H, Hoshi M, Matsumoto T, Irie M, Oura S, Tsutsumi H, Hata Y, Yamamoto Y, Saito K.
Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice.
Lipids Health Dis. 16:106, 2017. DOI:10.1186/s12944-017-0501-y - Sumi-Ichinose C, Suganuma Y, Kano T, Ihira N, Nomura H, Ikemoto K, Hata T, Katoh S, Ichinose H, Kondo K
Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia.
Physiol Rep 5:e13196, 2017. DOI:10.14814/phy2.13196 - Shibata Y, Hara T, Matsumoto T, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Goto N, Nannya Y, Ito H, Kito Y, Miyazaki T, Takeuchi T, Saito K, Seishima M, Takami T, Moriwaki H, Shimizu M, Tsurumi H.
Serum concentrations of l-kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified.
Hematol Oncol 35:637-644, 2017. DOI:10.1002/hon.2318 - Kiyokawa H, Yasuda H, Oikawa R, Okuse C, Matsumoto N, Ikeda H, Watanabe T, Yamamoto H, Itoh F, Otsubo T, Yoshimura T, Yoshida E, Nakagawa M, Koshikawa N & Seiki M
Serum monomeric laminin-gamma2 as a novel biomarker for hepatocellular carcinoma.
Cancer Science 108:1432-1439, 2017. DOI:10.1111/cas.13261 - Nagano H, Nakagawa Y, Ishikawa N, Watanabe Y, Miyabayashi Y, Nakayama A, Fujimoto M, Komai E, Shiga A, Tamura A, Kono T, Takiguchi T, Higuchi S, Sakuma I, Hashimoto N, Suzuki S, Koide H, Yokote K, Tanaka T.
SEVEN FAMILIAL DYSALBUMINEMIC HYPERTHYROXINEMIA CASES IN THREE UNRELATED JAPANESE FAMILIES AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ANALYSIS OF THE THYROXINE BINDING PROFILE.
Endocr Pract 23(11):1325-1332, 2017. DOI:10.4158/EP171964.OR - Yaguchi H., Yabe I., Takahashi H., Watanabe M., Nomura T., Kano T., Matsumoto M., Nakayama KI., Watanabe M., Hatakeyama S.
Sez6l2 regulates phosphorylation of ADD and neuritogenesis.
Biochem. Biophys. Res. Commun. 494:234-41, 2017. DOI:10.1016/j.bbrc.2017.10.047 - Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K
SIRT7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Biochem Biophys Res Commun 490:423-428, 2017. DOI:10.1016/j.bbrc.2017.06.057 - Satoko Suzuki, Noriko Ayukawa, Chisa Okada, Masami Tanaka, Susumu Takekoshi, Yoko Iijima, and Takatoshi Iijima.
Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons.
Scientific Reports 7:11405, 2017. DOI:10.1038/s41598-017-11319-5 - Higuchi T, Ishizaki Y, Noritake A, Yanagimoto Y, Kobayashi H, Nakamura K, Kaneko K.
Spatiotemporal characteristics of gaze of children with autism spectrum disorders while looking at classroom scenes.
PLoS ONE 12(5), 2017. DOI:10.1371/journal.pone.0175912 - Shuji Wakatsuki, Toshiyuki Araki
Specific phospholipid scramblases are involved in exposure of phosphatidylserine, an "eat-me" signal for phagocytes, on degenerating axons.
Commun Integr Biol 17:e1296615, 2017. DOI:10.1080/19420889.2017.1296615 - Ryo Watanabe, Haruki Mizoguchi, Hideaki, Oikawa, Hirofumi Ohashi, Koichi Watashi, HirokiOguri
Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents.
Bioorg. Med. Chem. 25(11):2851-2855, 2017. DOI:10.1016/j.bmc.2017.03.011 - Kimiko Shimizu and Yoshitaka Fukada
Stereotaxic Surgery for Suprachiasmatic Nucleus Lesions in Mice.
Bio-protocol 7:2346, 2017. DOI:10.21769/BioProtoc.2346 - Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H
Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor.
Neuroscience Letters 654:99-106, 2017. DOI:10.1016/j.neulet.2017.06.005 - Yonehara R., Nada S., Nakai T., Nakai M., Kitamura A., Ogawa A., Nakatsumi H., Nakayama KI., Li S., Standley DM., Yamashita E., Nakagawa A., Okada M.
Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nature Commun. 8:1625, 2017. DOI:10.1038/s41467-017-01762-3 - K. Ito, Y. Mutoh, S. Saito
Synthesis of [2]Catenanes by Intramolecular Sonogashira-Type Reaction.
JOURNAL OF ORGANIC CHEMISTRY 82:6188-6124, 2017. DOI:10.1021/acs.joc.7b00672 - Yamazaki, Y.; Mutoh, Y.; Saito, S.
Synthesis of Interlocked Compounds by Utilizing Bond-forming Reactions Mediated by Macrocyclic Phenanthroline-Cu Complexes.
CHEMISTRY LETTERS 46:904-912, 2017. DOI:10.1246/cl.170031 - Y. Mochizuki, K. Ikeyatsu, Y. Mutoh, S. Hosoya, S. Saito
Synthesis of Mechanically Planar Chiral rac-[2]Rotaxanes by Partitioning of an Achiral [2]Rotaxane: Stereoinversion Induced by Shuttling.
ORGANIC LETTERS 19:4347-4350, 2017. DOI:10.1021/acs.orglett.7b02043 - Nakamura T, Okabe S, Yoshida H, Iida K, Ma Y, Sasaki S, Yamori T, Shin-Ya K, Nakano I, Nagasawa K, Seimiya H.
Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole.
Scientific Reports 7:e3605, 2017. DOI:10.1038/s41598-017-03785-8 - Aizawa F, Ogaki Y, Kyoya N, Nakamoto K, Kurihara T, Hirasawa A, Miyata A, Tokuyama S,
The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice.
Biol Pharm Bull 40:1255-1259, 2017. DOI:10.1248/bpb.b17-00082 - Park S, Mori R, Shimokawa I
The fat regulator neuropeptide Y and caloric restriction.
Aging (Albany NY) 9(11):2243-2244, 2017. DOI:10.18632/aging.101338 - Nobuhiko Takai, Masatsugu Ohgami, Koichi Ando, Akiko Uzawa, Ryoichi Hirayama, Saori Nakamura, Yoshihito Ohba
THE FOCAL BRAIN IRRADIATION OF PROTON BEAM INSULT IN RATS INDUCED MEMORY DISTURBANCE RELATED CHANGE IN ACETYLCHOLINE RECEPTOR BINDING.
RadProc vol.2:25-29, 2017. DOI:10.21175 - Mouri A, Noda Y, Niwa M, Matsumoto Y, Mamiya T, Nitta A, Yamada K, Furukawa S, Iwamura T, Nabeshima T.
The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization.
Behav Brain Res. 329:157-165, 2017. DOI:10.1016/j.bbr.2017.04.052 - Yahiro, T., Kataoka, N., Nakamura, Y., Nakamura, K.
The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation.
Scientific Reports 7:5031, 2017. DOI:10.1038/s41598-017-05327-8 - Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I, Wakana S, Yamaguchi M, Shitara H, Taya C, Karaplis AC, Kominami R, and Wakabayashi Y
The parathyroid hormone regulates skin tumour susceptibility in mice.
Scientific Reports 7(1):11208, 2017. DOI:10.1038/s41598-017-11561-x - Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I, Wakana S, Yamaguchi M, Shitara H, Taya C, Karaplis AC, Kominami R, and Wakabayashi Y.
The parathyroid hormone regulates skin tumour susceptibility in mice.
Scientific Reports 7 (1):11208, 2017. - Murakami Y, Fukui R, Motoi Y, Shibata T, Saitoh SI, Sato R, Miyake K.
The Protective Effect of the anti-Toll-like Receptor 9 Antibody Against Acute Cytokine Storm Caused by Immunostimulatory DNA.
Sci Rep 7:44042, 2017. DOI:10.1038/srep44042 - Kake S, Tsuji S, Enjoji S, Hanasaki S, Hayase H, Yabe R, Tanaka Y, Nakagawa T, Liu HP, Chang SC, Usui T, Ohama T*, Sato K
The Role of SET/I2PP2A in canine mammary tumors.
Scientific Reports 27:4279, 2017. DOI:10.1038/s41598-017-04291-7 - Takakura Y, Yamaguchi N, Honda T, Morii M, Yuki R, Nakayama Y, Yamaguchi N
The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALK(ATI)) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner.
Biol Pharm Bull. 40(11):1968-1975, 2017. DOI:10.1248/bpb.b17-00548 - Yuichiro Yoneoka, Junichi Yoshimura, Masakazu Sano, Masayasu Okada, Akiyoshi Kakita, Yukihiko Fujii
Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement.
Pediatr Neurosurg. 53(1):49-54, 2017. DOI:10.1159/000480021 - Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI.
Thymidine Catabolism as a Metabolic Strategy for Cancer Survival.
Cell Reports 19:1313-1321, 2017. DOI:10.1016/j.celrep.2017.04.061 - Ogura H, Nagatake-Kobayashi Y. Adachi J, Tomonaga T, Fujita N, *Katayama R.
TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity.
Scientific Reports 7:5519, 2017. DOI:10.1038/s41598-017-05736-9 - Saitoh S, Abe F, Kanno A, Tanimura N, Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K, and Miyake K
TLR7 Mediated Viral Recognition Results in Focal Type I Interferon Secretion by Dendritic Cells.
Nat. Commun. 8(1):1592, 2017. DOI:10.1038/s41467-017-01687-x - Eisuke Sato, Miho Sato, Yurika Tanabe, Naoya Nakajima, Akifumi Ohkubo, Kiyotake Suenaga
Total Synthesis of Biselyngbyaside.
The Jornal of Organic Cehmistry 82 (13):6770-6777, 2017. DOI:10.1021/acs.joc.7b00905 - Wong-Lin K, Wang DH, Moustafa AA, Cohen JY, Nakamura K.
Toward a multiscale modeling framework for understanding serotonergic function.
Journal of psychopharmacology 31(9):1121-1136, 2017. DOI:10.1177/0269881117699612 - Magi S, Iwamoto K, Yumoto N, Hiroshima M, Nagashima T, Ohki R, Garcia-Munoz A, Volinsky N, Kriegsheim AV, Sako Y, Takahashi K, Kimura S, Kholodenko BN, Okada-Hatakeyama M
Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization.
J Biol Chem 293:2206-2218., 2017. DOI:10.1074/jbc.M117.778399 - Nomiyama H, Osada N, Takahashi I, Terao K, Yamagata K, Yoshie O
Translational repression of a splice variant of cynomolgus macaque CKCL1L by its C-terminal sequence.
Journal of Interferon and Cytokine Research 37:129-138, 2017. DOI:10.1089/jir.2016.0085 - Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K*.
Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Exp Neurol 293:1-12, 2017. DOI:10.1016/j.expneurol.2017.03.009 - Kano M, Watanabe T
Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease.
F1000Research 6:416, 2017. DOI:10.12688/f1000research.10485.1 - Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R.
Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.
Cell Res. 27:657-6674, 2017. DOI:10.1038/cr.2017.40 - Oh Y-M, Karube F…Fujiyama F. et al.
Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations.
Brain Struct Funct 222:2359-2378, 2017. DOI:10.1007/s00429-016-1346-2 - Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T.
Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.
JCI Insight 2(1):e89462, 2017. DOI:10.1172/jci.insight.89462 - Honda T, Morii M, Nakayama Y, Suzuki K, Yamaguchi N, Yamaguchi N
v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling.
Sci Rep. 8:1063, 2017. DOI:10.1038/s41598-018-19599-1 - Aonuma H., Kaneda M., Hatakeyama D., Watanabe T., Lukowiak K. and Ito E.
Weak involvement of octopamine in aversive taste learning in a snail.
Neurobiol. Learn. Mem. 141:189-198, 2017. DOI:10.1016/j.nlm.2017.04.010 - 斎藤慎一， 片村友大， 武藤雄一郎
アジリジン，アゼチジンの環拡大反応を利用したN-ヘテロ環合成法の開発.
有機合成化学協会誌 75:340-348, 2017. DOI:10.5059/yukigoseikyokaishi.75.340 - 山中章弘
オレキシン神経活動操作による機能解明.
睡眠医療 11(1):19-25, 2017. - 設樂久志，小川宏人
コオロギの音源定位ナビゲーション－神経行動学が迫る動物のナビゲーションメカニズム.
生物の科学 遺伝 71:519-525, 2017. - Iijima J, Kobayashi S, Kitazume S, Kizuka Y, Fujinawa R, Korekane H, Shibata T, Saitoh SI, Akashi-Takamura S, Miyake K, Miyoshi E, Taniguchi N.
タンパク質におけるフコース修飾の意義の解析.
Glycobiology 27(11):1006-1015, 2017. DOI:10.1093/glycob/cwx075 - Sato R*, Shibata T*, Tanaka Y, Kato C, Yamaguchi K, Furukawa Y, Shimizu E, Yamaguchi R, Imoto S, Miyano S, Miyake K. (* equally contributed)
ノックアウトライブラリーを用いた分子探索.
Int Immunol 29(8):347-355, 2017. DOI:10.1093/intimm/dxx044 - 河原康一、古川龍彦
核小体によるp53制御とがん治療薬開発の新展開.
実験医学 35:2365-2367, 2017. - 山中章弘
光遺伝学による神経科学研究の新展開.
医学のあゆみ 262(5):491-495, 2017. - 山中章弘
光遺伝学による睡眠覚醒の制御.
生体の科学 65(5):484-485, 2017. - Otsuka I, Izumi T, Boku S, Kimura A, Zhang Y, Mouri K, Okazaki S, Shiroiwa K, Takahashi M, Ueno Y, Shirakawa O, Sora I, Hishimoto A.
自殺既遂者におけるテロメア長とミトコンドリアDNAコピー数の研究.
Sci Rep. 7(1):31-76, 2017. - 山中章弘
睡眠のマニピュレーション-光遺伝学、薬理遺伝学を用いた睡眠覚醒の操作.
医学のあゆみ 263(9):765-774, 2017. - Wu MK, Takemoto M, Taniguchi M, Takumi T, Okazaki T, Song W-J.
Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1.
American Journal of Physiology-Cell Physiology 311(1):C15-23, 2016. DOI:10.1152/ajpcell.00272.2015 - 岡田正康
軸索再生に対するGAP-43の機能解明:GAP-43 (Ser96)のリン酸化は軸索再生の分子マーカーとなる.
新潟医学会雑誌 130(7):405-419, 2016. - Katsutoshi Imamura, Akiko Takaya, Yo-ichi Ishida, Yayoi Fukuoka, Toshiki Taya, Ryo Nakaki, Miho Kakeda, Naoto Imamachi, Aiko Sato, Toshimichi Yamada, Yutaka Suzuki, Masami Nagahama, Tomoko Yamamot, Torben Heick Jensen, Nobuyoshi Akimitsu
Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs.
EMBO Journal
2016年度
- Hiroshi Fukamachi, Seon-Kyu Kim, Jiwon Koh, Hye Seung Lee, Yasushi Sasaki, Kentaro Yamashita, Taketo Nishikawaji, Shu Shimada, Yoshimitsu Akiyama, Sun-ju Byeon, Dong-Hyuck Bae, Keisuke Okuno, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Hiroshi Kawachi, Kiichiro Tsuchiya, Kazuyuki Kojima, Takashi Tokino, Yoshinobu Eishi, Yong Sung Kim, Woo Ho Kim, Yasuhito Yuasa, and Shinji Tanaka
A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors.
Journal of Experimental & Clinical Cancer Research 38:127, 2019. DOI:10.1186/s13046-019-1121-3 - Kanetake T, Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, Kihara A
Neural symptoms in a gene knockout mouse model of Sj?gren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide.
FASEB Journal 33:928-941, 2019. DOI:10.1096/fj.201800291R - Kasahara Y, Sakakibara Y, Hiratsuka T, Moriya Y, Lesch KP, Hall FS, Uhl GR, Sora I
Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice.
Neuropsychopharmacology Reports 39:130-133, 2019. DOI:10.1002/npr2.12049 - Kano T., Sato E., Ono T., Aonuma H., Matsuzaka Y. and Ishiguro A.
A brittle star-like robot capable of immediately adapting to unexpected physical damage.
Royal Soc. Open Sci. 4:171200, 2018. DOI:10.1098/rsos.171200 - Sumitani M, Nishizawa D, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain.
Pain Medicine 19:348-354, 2018. DOI:10.1093/pm/pnx102 - DiRienzo, N. and Aonuma H.
Plasticity in extended phenotype increases offspring defense despite individual variation in web structure and behavior.
Animal Behav. 138:9ｰ17, 2018. DOI:10.1016/j.anbehav.2018.01.022 - Kai Kitamura, Hiroaki Itoh, Kaori Sakurai, Shingo Dan, Masayuki Inoue
Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase.
Journal of the American Chemical Society 140(38):12189-12199, 2018. DOI:10.1021/jacs.8b07339 - Motohiro Nozumi, Michihiro Igarashi
Vesicular movements in the growth cone.
Neurochemistry International 119:71-76, 2018. DOI:10.1016/j.neuint.2017.09.011 - Shiratori C., Suzuki N., Momohara Y., Shiraishi K., Aonuma H., and Nagayama T.
Cyclic AMP-regulated opposing and parallel effects of serotonin and dopamine on phototaxis in the Marmorkrebs (marbled crayfish).
Europ. J. Neurosci. 46:1863-1874, 2017. DOI:10.1111/ejn.13632 - Saito T, Ishii A, Sugai K, Sasaki M, Hirose S.
A de novo missense mutation in SLC12A5 found in a compound heterozygote patient with epilepsy of infancy with migrating focal seizures.
Clinical Genetics 92(6):654-658, 2017. DOI:10.1111/cge.13049 - Matsumoto M., Matsuzaki F., Oshikawa K., Goshima N., Mori M., Kawamura Y., Ogawa K., Fukuda E., Nakatsumi H., Natsume T., Fukui K., Horimoto K., Nagashima T., Funayama R., Nakayama K. & Nakayama KI.
A large-scale targeted proteomics assay resource based on an in vitro human proteome.
Nature Methods 14:251-8, 2017. DOI:10.1038/nmeth.4116 - Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, *Komatsu M.
A novel approach to assess the ubiquitin-fold modifier 1-system in cells.
FEBS Lett. 591:196-204, 2017. DOI:10.1002/1873-3468.12518 - Uchida T, Lossin C, Ihara Y, Deshimaru M, Yanagawa Y, Koyama S, Hirose S.
Abnormal gamma-aminobutyric acid neurotransmission in a Kcnq2 model of early onset epilepsy.
Epilepsia 58(8):1430-1439, 2017. DOI:10.1111/epi.13807 - Ayumi Hashimoto, Toyohiro Sawada, Itsuki Kageyama, Kiyohisa Natsume
Activation of the muscarinic receptors induces the transition of the epileptic discharges to beta oscillation in hippocampal slices.
Biophysics_and Physicobiology 14:137-146, 2017. DOI:10.2142/biophysico.14.0_137 - *Ueno T, *Komatsu M.
Autophagy in the liver: functions in health and disease.
Nat Rev Gastroenterol Hepatol. 14:170-184, 2017. DOI:10.1038/nrgastro.2016.185 - Uchibori K, Inase N, Araki M, Kamada M, Sato S, Okuno Y, Fujita N, *Katayama R.
Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer.
Nature communications 8:14768, 2017. DOI:10.1038/ncomms14768 - Sho Wakayama, Shigeki Kiyonaka, Itaru Arai, Wataru Kakegawa, Shinji Matsuda, Keiji Ibata, Yuri L. Nemoto, Akihiro Kusumi, Michisuke Yuzaki & Itaru Hamachi
Chemical labeling for visualizing native AMPA receptors in live neurons.
Nature Communications 8:e14850, 2017. DOI:10.1038/ncomms14850 - Ishii A, Watkins JC, Chen D, Hirose S, Hammer MF.
Clinical implications of SCN1A missense and truncation variants in a large Japanese cohort with Dravet syndrome.
Epilepsia 58(2):282-290, 2017. DOI:10.1111/epi.13639 - Jun Nakayama, Emi Ito, Jiro Fujimoto, Shinya Watanabe and Kentaro Semba
Comparative analysis of gene regulatory networks of highly metastatic breast cancer cells established by orthotopic transplantation and intra-circulation injection.
International Journal of Oncology 50.2:497-504, 2017. DOI:10.3892/ijo.2016.3809 - Nozumi M, Nakatsu F, Katoh K, *Igarashi M
Coordinated movement of vesicles and actin bundles during nerve growth revealed by superresolution microscopy.
Cell Rep 18:2203-2216, 2017. DOI:10.1016/j.celrep.2017.02.008 - Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.
J Clin Endocrinol Metab 101(3):841-6, 2017. DOI:10.1210/jc.2015-2855 - Goto E, Tokunaga F.
Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.
Biochemical and Biophysical Research Communications 485(1):152-159, 2017. DOI:10.1016/j.bbrc.2017.02.040 - Gen Shiihashi, Daisuke Ito, Itaru Arai, Yuki Kobayashi, Kanehiro Hayashi, Shintaro Otsuka, Kazunori Nakajima, Michisuke Yuzaki, Shigeyoshi Itohara, Norihiro Suzuki
Dendritic homeostasis disruption in a novel frontotemporal dementia mouse model expressing cytoplasmic fused in sarcoma.
EBioMedicine 24:102-115, 2017. DOI:10.1016/j.ebiom.2017.09.005 - Kanki, Y., Nakaki, R., Shimamura, T., Matsunaga, T., Yamamizu, K., Katayama, S., Suehiro, J.I., Osawa, T., Aburatani, H., Kodama, and Minami, T
Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation.
Nuc.Acids.Res 2017 45:4344-58, 2017. - Furuya M, Hasumi H, Baba M, Tanaka R, Iribe Y, Onishi T, Nagashima Y, Nakatani Y, Isono Y, Yao M
Establishment and characterization of BHD-F59RSVT, an immortalized cell line derived from a renal cell carcinoma in a patient with Birt-Hogg-Dub? syndrome.
Laboratory Investigation 97(3):343-351, 2017. DOI:10.1038/labinvest.2016.137 - Honda A, Ito Y, Takahashi-Niki K, Matsushita N, Nozumi M, Tabata H, Takeuchi K, *Igarashi M
Extracellular signals induce glycoprotein M6a clustering of lipid rafts and associated signaling molecules.
J Neurosci 37:4046-4064, 2017. DOI:10.1523/JNEUROSCI.3319-16.2017 - Yamauchi T., Nishiyama M., Moroishi T., Kawamura A., Nakayama KI.
FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem-progenitor cells.
Mol. Cell. Biol. 37:e00470-16, 2017. DOI:10.1128/MCB.00470-16 - Tanabe K, Shinsato Y, Furukawa T, Kita Y, Hatanaka K, Minami K, Kawahara K, Yamamoto M, Baba K, Mori S, Uchikado Y, Maemura K, Tanimoto A, Natsugoe S
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
Oncotarget 8:6353-6363, 2017. DOI:10.18632/oncotarget.14087 - Kayama K., Watanabe S., Takafuji T., Tsuji T., Hironaka K., Matsumoto M., Nakayama KI., Enari M., Kohno T., Shiraishi K., Kiyono T., Yoshida K., Sugimoto N., Fujita M.
GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
EMBO Rep. 18:123-37, 2017. DOI:10.15252/embr.201642444 - Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue J.
HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.
PLoS Pathogens 13:e100162, 2017. DOI:10.1371/journal.ppat.1006162 - Jinshu Xu, Ueno H,Chelsea Xu, Binglai Chen, Irving Weissman, and Pin-Xian Xu.
Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti.
Nature Communications 8, 15046, 2017. DOI:10.1038/ncomms15046 - Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y.
Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice.
Gastroenterology 152(1):218-231.e14, 2017. DOI:10.1053/j.gastro.2016.09.018 - T. Hara, T. Kojima, H. Matsuzaki, T. Nakamura, E. Yoshida, Y. Fujiwara, C. Yamamoto, S. Saito, T. Kaji
Induction of Syndecan-4 by Organic-Inorganic Hybrid Molecules with a 1,10-Phenanthroline Structure in Cultured Vascular Endothelial Cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18:352, 2017. DOI:10.3390/ijms18020352 - Numata T, Tsumoto K, Yamada K, Kurokawa T, Hirose S, Nomura H, Kawano M, Kurachi Y, Inoue R, Mori Y.
Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing.
Scientific Reports 7(1):9760, 2017. DOI:10.1038/s41598-017-10357-3 - Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Saiga K, Ohsugi H, Tokuyama Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M, and Ueno H.
Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion.
Scientific Reports 7, 41838, 2017. DOI:10.1038/srep41838 - Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Saiga K, Ohsugi H, Tokuyama Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M, and Ueno H.
Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity.
Scientific Reports 7, 9891, 2017. DOI:10.1038/s41598-017-09927-2 - Jin M, Pomp O, Shinoda T, Toba S, Torisawa T, Furuta K, Oiwa K, Yasunaga T, Kitagawa D, Matsumura S, Miyata T, Tan TT, Reversade B, Hirotsune S.
Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.
Sci Rep. 7:e39902, 2017. DOI:10.1038/srep39902 - Zamani A, Sakuragi S, Ishizuka T, Yawo H.
Kinetic characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization.
Biophys Physicobiol. 14:13-22, 2017. DOI:10.2142/biophysico.14.0_13 - Jin Cui, Maho Morita, Osamu Ohno, Tomoyuki Kimura, Toshiaki Teruya, Takumi Watanabe, Kiyotake Suenaga, and Masakatsu Shibasaki:
Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis.
Chemistry An Eurean Journal 23 (35):8500-8509, 2017. DOI:10.1002/chem.201701183 - Nakamura, Y., Yanagawa, Y., Morrison, S.F., Nakamura, K.
Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication.
Cell Metabolism 25:322?334, 2017. DOI:10.1016/j.cmet.2016.12.002 - Matsumoto A., Pasut A., Matsumoto M., Yamashita R., Fung J., Saghatelian A., Nakayama KI., Clohessy JG., Monteleone E., Pandolfi PP.
mTORC1 and muscle regeneration are regulated by the LINC00961 encoded SPAR polypeptide.
Nature 541:228-32, 2017. DOI:10.1038/nature21034 - Hayashi K, Katanosaka K, Abe M, Yamanaka A, Nosaka K, Mizumura K, *Taguchi T
Muscular mechanical hyperalgesia after lengthening contractions in rats depends on stretch velocity and range of motion.
European Journal of Pain 21(1):125-139, 2017. DOI:10.1002/ejp.909 - Misako Matsushita, Yuhki Nakatake, Itaru Arai, Keiji Ibata, Kazuhisa Kohda, Sravan Goparaju, Miyako Murakami, Miki Sakota, Nana Chikazawa-Nohtomi, Shigeru Ko, Takanori Kanai, Michisuke Yuzaki & Minoru S.H. Ko
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Biochemical and Biophysical Research Communications 490:296-301, 2017. DOI:10.1016/j.bbrc.2017.06.039 - Ishii A, Hirose S.
New Genes for Epilepsy - Autism Comorbidity.
Journal of Pediatric Neurology 15(3):105-114, 2017. DOI:10.1055/s-0037-1602822 - Matsuzaka Y, Sato E., Kano T., Aonuma H. and Ishiguro A.
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Biology Open 6:425-438, 2017. DOI:10.1242/bio.019836 - Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Ueno H, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, and Kuo CJ.
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Nature 545:238-242, 2017. DOI:10.1038/nature22313 - Sasaki M, Ishii A, Saito Y, Hirose S.
Progressive Brain Atrophy in Alternating Hemiplegia of Childhood.
Movement Disorders Clinical Practice 4(3):406-411, 2017. DOI:10.1002/mdc3.12451 - Furuse T., Miyake K., Kohda T., Kaneda H., Hirasawa T., Yamada I., Kushida T., Kashimura M., Kobayashi K., Ishino F., Kubota T., Wakana S.
Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny.
Genes & Nutrition, 2017. DOI:10.1186/s12263-016-0550-2 - Hammer MF, Ishii A, Johnstone L, Tchourbanov A, Lau B, Sprissler R, Hallmark B, Zhang M, Zhou J, Watkins J, Hirose S.
Rare variants of small effect size in neuronal excitability genes influence clinical outcome in Japanese cases of SCN1A truncation-positive Dravet syndrome.
PLoS ONE 12(7):e0180485, 2017. DOI:10.1371/journal.pone.0180485 - Morinaga T, Yanase S, Okamoto A, Yamaguchi N, Yamaguchi N
Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells.
Sci Rep. 7:493, 2017. DOI:10.1038/s41598-017-00538-5 - Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H.
Reduced SHARPIN and LUBAC formation may contribute to CCl4- or acetaminophen-induced liver cirrhosis in mice.
International Journal of Molecular Sciences 18:326, 2017. DOI:10.3390/ijms18020326 - Morii M, Kubota S, Honda T, Yuki R, Morinaga T, Kuga T, Tomonaga T, Yamaguchi N, Yamaguchi N
Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530.
J Biol Chem. 292(5):1648-1665, 2017. DOI:10.1074/jbc.M116.753202 - Ohnishi T., Shirane M., Nakayama KI.
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Sci. Rep. 7:41130, 2017. DOI:10.1038/srep41130 - T. Fukuda, T. Katae, I. Harada, M. Iwao
Synthesis of Lamellarins via Regioselective Assembly of 1,2-Diarylated [1]Benzopyrano[3,4-b]pyrrol-4(3H)-one Core.
Heterocycles 95 (2):950-971, 2017. DOI:10.3987/COM-16-S(S)63 - Katamura, T.; Shimizu, T.; Mutoh, Y.; Saito, S.
Synthesis of Tricyclic Benzazocines by Aza-Prins Reaction.
Organic Letters 19(1):266-269, 2017. DOI:10.1021/acs.orglett.6b03577 - Hanaya R, Niantiarno FH, Kashida Y, Hosoyama H, Maruyama S, Otsubo T, Tanaka K, Ishii A, Hirose S, Arita K.
Vagus nerve stimulation for genetic epilepsy with febrile seizures plus (GEFS+) accompanying seizures with impaired consciousness.
Epilepsy & Behavior Case Reports 7:16-19, 2017. DOI:10.1016/j.ebcr.2016.11.001 - 山中章弘
睡眠覚醒調節におけるオレキシンの役割.
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動物心理学研究における還元・比較・発生―研究遍歴をめぐる対談をふまえて―.
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CHD7 promotes proliferation of neural stem cells mediated by MIF.
Molecular Brain 9(1):96, 2016. DOI:10.1186/s13041-016-0275-6 - Etsu Tashiro, Shizuka, Henmi, Hiroyuki Odake, Seitaro Ino, Masaya Imoto
Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation.
Biochem Biophys Res Commun 477:801-806, 2016. DOI:10.1016/j.bbrc.2016.06.138 - Muramatsu, M. and Minami, T
Oncogenic combined calcineurin-NFAT and TLR signals in colon.
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Novel Method to Rescue a Lethal Phenotype Through Integration of Target Gene Onto the X-chromosome.
Sci Rep. 6:37200, 2016. DOI:10.1038/srep37200 - Hoque MR, Ishizuka T, Inoue K, Abe-Yoshizumi R, Igarashi H, Mishima T, Kandori H, Yawo H.
A Chimera Na+-Pump Rhodopsin as an Effective Optogenetic Silencer.
PLoS One. 11(11):e0166820, 2016. DOI:10.1371/journal.pone.0166820 - Ishii A, Kang JQ, Schornak CC, Hernandez CC, Shen W, Watkins JC, Macdonald RL, Hirose S.
A de novo missense mutation of GABRB2 causes early myoclonic encephalopathy.
Journal of Medical Genetics 54(3):202-211, 2016. DOI:10.1136/jmedgenet-2016-104083 - Igarashi H, Koizumi K, Kaneko R, Ikeda K, Egawa R, Yanagawa Y, Muramatsu S, Onimaru H, Ishizuka T, Yawo H.
A Novel Reporter Rat Strain That Conditionally Expresses the Bright Red Fluorescent Protein tdTomato.
PLoS One. 11(5):e0155687, 2016. DOI:10.1371/journal.pone.0155687 - Ayumi Suzuki, Takahiro Arai, Kota Ikenaga, Yuichiro Mutoh, Noriko Tsuchida, Scinchi Saito, Youichi Ishii
A ruthenium tellurocarbonyl (CTe) complex with a cyclopentadienyl ligand: Systematic studies of a series of the chalcogenocarbonyl complexes [CpRuCl(CE)(H2IMes)] (E = O, S, Se, Te).
DALTON TRANSACTIONS 46:44 - 48, 2016. DOI:10.1039/C6DT04440A - Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T, Yamaoka S.
A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.
Leukemia 30(3):716-727, 2016. DOI:10.1038/leu.2015.267 - Ohta H, Kohno Y, Arake M, Tamura R, Yukawa S, Sato Y, Morimoto Y, Nishida Y, Yawo H.
Adrenergic receptor-mediated modulation of striatal firing patterns.
Neurosci Res. 112:47-56, 2016. DOI:10.1016/j.neures.2016.05.004 - Hosokawa H., Tanaka T., Endo Y., Kato M., Shinoda K., Suzuki A., Motohashi S., Matsumoto M., Nakayama KI., Nakayama T.
Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.
Nature Commun. 7:11289, 2016. DOI:10.1038/ncomms11289 - Connor SA, Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Kurihara N, Tada A, Ge Y, Lu H, Yan R, LeDue JM, Matsumoto M, Kiyonari H, Kirino Y, Matsuzaki F, Suzuki T, Murphy TH, Wang YT, Yamamoto T, Craig AM
Altered cortical dynamics and cognitive function upon haploinsufficiency of the autism linked excitatory synaptic suppressor MDGA2.
Neuron 91:1052-1068, 2016. DOI:10.1016/j.neuron.2016.08.016 - Yamashita-Sugahara Y, Matsumoto M, Ohtaka M, Nishimura K, Nakanishi M, Mitani K, Okazaki Y
An inhibitor of Fibroblast Growth Factor Receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors.
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Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.
Biochim Biophys Acta. 1861:1816-1827, 2016. DOI:10.1016/j.bbalip.2016.09.006 - Saito S, Fujimaki T, Panbangred W, Igarashi Y and Imoto M
Antarlides, A new-type of Androgen Receptor (AR) Antagonist, that overcomes resistance to AR-targeted Therapy.
Angewandte Chemie Int. Ed. 55:2728-2732, 2016. DOI:10.1002/anie.201510079 - Moinuddin FM, Shinsato Y, Komatsu M, Mitsuo R, Minami K, Yamamoto M, Kawahara K, Hirano H, Arita K, Furukawa T
ATP7B expression confers multidrug resistance through drug sequestration.
Oncotarget 7:22779-90, 2016. DOI:10.18632/oncotarget.8059 - Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A.
Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.
Elife 5, 2016. DOI:10.7554/eLife.14810 - Muona, M., *Lehesjoki, AE., *Komatsu, M (28人中28番目).
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.
Am. J. Hum. Genet 99:683-694, 2016. DOI:10.1016/j.ajhg.2016.06.020 - Tanaka T, Atsumi N, Nakamura N, Yanai H, Komai Y, Omachi T, Tanaka K, Saiga K, Ohsugi H, Tokuyama Y, Hisha H, Yoshida N, Kumano K, Okazaki K, and Ueno H.
Bmi1-positive cells in the lingual epithelium could serve as cancer stem cells in tongue cancer.
Scientific Reports 6, 39386, 2016. DOI:10.1038/srep39386 - Tuboly E, Futakuchi M, Varga G, Erces D, Tokes T, Meszaros A, Kaszaki J, Suzui M, Imai M, Okada A, Okada N, Boros M, Okada H
C5a inhibitor protects ischemia/reperfusion injury in rat small intestine.
Microbiol Immunol 60(1):35-46, 2016. DOI:10.1111/1348-0421 - Mehanna S, Suzuki C, Shibata M, Sunabori T, Imanaka T, Araki K, Yamamura K, Uchiyama Y,?Ohmuraya?M
Cathepsin D in Pancreatic Acinar Cells Is Implicated in Cathepsin B and L Degradation, but Not in Autophagic Activity.
Biochem Biophys Res Commun 469（9）:405-411, 2016. DOI:10.1016/j.bbrc.2015.12.002 - Nomoto, M., Ohkawa, N., Nishizono, H., Yokose, J., Suzuki, A., Matuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A.M., Kato, F., Inokuchi, K.
Cellular tagging as a neural network mechanism for behavioral tagging.
Nature Communications 7:12319, 2016. DOI:10.1038/ncomms12319 - Hiroshi Yamada, Hitoshi Inokawa, Yukiko Hori, Xiaochuan Pan, Ryuichi Matsuzaki, Kae Nakamura, Kazuyuki Samejima, Munetaka Shidara d, Minoru Kimura, Masamichi Sakagami, Takafumi Minamimoto
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Neuroscience research 105:2-18, 2016. DOI:10.1016/j.neures.2015.10.003 - Motojima M, Tanimoto S, Ohtsuka M, Matsusaka T, Kume T, Abe K
Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2.
Cells Tissues Organs 201:380-389, 2016. DOI:10.1159/000445027 - Katayama Y., Nishiyama M., Shoji H., Ohkawa Y., Kawamura A., Sato T., Suyama M., Takumi T., Miyakawa T., Nakayama KI.
CHD8 haploinsufficiency results in autistic-like phenotypes in mice.
Nature 537:675-9, 2016. DOI:10.1038/nature19357 - Yan M, Audet-Walsh ?, Manteghi S, Rosa Dufour C, Walker B, Baba M, St-Pierre J, Gigu?re V, Pause A
Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.
Genes & Development 30(9):1034-1046, 2016. DOI:10.1101/gad.281410.116 - Kimura, H., Fumoto, K., Shojima, K., Nojima, S., Osugi, Y., Tomihara, H., Eguchi, H., Shintani, Y., Endo, E., Inoue, M., Doki, Y., Okumura, M., Morii, E., and Kikuchi, A
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression.
J Clin. Invest. 126(7):2689-2705, 2016. DOI:10.1172/JCI84658 - Motojima M, Ogiwara S, Matsusaka T, Kim SY, Sagawa N, Abe K, Ohtsuka M.
Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system.
Mammalian genoem 27:62-69, 2016. DOI:10.1007/s00335-015-9610-y - Koso H, Tsuhako A, Lai CY, Baba Y, Otsu M, Ueno K, Nagasaki M, Suzuki Y, Watanabe
Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina.
Glia 64(11):2005-2024, 2016. DOI:10.1002/glia.23038 - Matsumoto N, Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, Siomi MC, Nureki O.
Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA.
Cell 167:484-497, 2016. DOI:10.1016/j.cell.2016.09.002 - Jayapal SR, Ang HY, Wang CQ, Bisteau X, Caldez MJ, Xuan GX, Yu W, Tergaonkar V, Osato M, Lim B, Kaldis P.
Cyclin A2 regulates erythrocyte morphology and numbers.
Cell Cycle 15(22):3070-3081, 2016. DOI:10.1080/15384101.2016.1234546 - T. Hara, H. Matsuzaki, T. Nakamura, E. Yoshida, T. Ohkubo, H. Maruyama, C. Yamamoto, S. Saito, T. Kaji
Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells.
Fundamental Toxicological Sciences 3:109 - 113, 2016. DOI:10.2131/fts.3.109 - Saito A, Taniguchi Y, Kim SH, Selvakumar B, Perez G, Ballinger MD, Zhu X, Sabra J, Jallow M, Yan P, Ito K, Rajendran S, Hirotsune S, Wynshaw-Boris A, Snyder SH, Sawa A, Kamiya A.
Developmental Alcohol Exposure Impairs Activity-Dependent S-Nitrosylation of NDEL1 for Neuronal Maturation.
Cereb Cortex. 27:3918-3929., 2016. DOI:10.1093/cercor/bhw201 - *Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D
Direct Projections from Hypothalamic Orexin Neurons to Brainstem Cardiac Vagal Neurons.
Neuroscience 339:47-53, 2016. DOI:10.1016/j.neuroscience.2016.09.038 - Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, Kihara A
Disruption of the Sj?gren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
Journal of Biological Chemistry 291(22):11676-11688, 2016. DOI:10.1074/jbc.M116.714030 - Hengguang Zhao, Rieger S, Abe K, Hewison M, Lisse T.
DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization.
Int. J. Mol. Sci. 17:1984, 2016. DOI:10.3390/ijms17121984 - Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T.
Dopamine D2L receptor is required for visual discrimination learning.
Molecular Neuropsychiatry 2 (3):124-132, 2016. DOI:10.1159/000447970 - 山中章弘
DREADD による神経活動操作と精神医学研究.
分子精神医学 16(3):45(189)-47(191), 2016. - Tsuji, M., Takahashi, Y., Watabe, A.M., Kato, F.
Enhanced long-term potentiation in mature rats with a history of cryptogenic infantile spasms.
Epilepsia 57(3):495-505, 2016. DOI:10.1111/epi.13315 - Fujii, S., Shinjo, K., Matsumoto, S., Harada, T., Nojima, S., Sato, S., Usami, Y., Toyosawa, S., Morii, E., Kondo, Y., and Kikuchi, A
Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3'-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma.
Oncotarget 7:81571-81587, 2016. DOI:10.18632/oncotarget.13147 - Kikuta S, Ynagawa Y, Homma N, Osanai M
Evaluation of the amount of the manganese entry in the neurons for activity-induced manganese-enhanced MRI.
Electronics and Communications in Japan 99(8):48-53, 2016. DOI:10.1002/ecj.11838 - Adachi T, Hayashi T
Evolutionarily conserved phosphorylation and palmitoylation-dependent regulation of dopamine D1-like receptors in vertebrates.
Neurotransmitter 3:e1434, 2016. DOI:10.14800/nt.1434 - Pei W Tanaka K, Huang SC, Xu L, Liu B, Sinclair J, Idol J, Varshney GK, Huang H, Lin S, Nussenblatt RB, Mori R, Burgess SM
Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation.
NPJ Regen Med 1:16013, 2016. DOI:10.1038/npjregenmed.2016.13 - Lee DH, Han DH, Nam KT, Park JS, Kim SH, Lee M, Kim G, Min BS, Cha BS, Lee YS, Sung SH, Jeong H, Ji HW, Lee MJ, Lee JS, Lee HY, Chun Y, Kim J, Komatsu M, Lee YH, Bae SH.
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
Free Radic Biol Med. 99:520-532, 2016. DOI:10.1016/j.freeradbiomed.2016.09.009 - Horigane S*, Ageta-Ishihara N*(*共同筆頭著者), Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S, Bito H.
Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKI? pathway during neuronal polarization.
Molecular brain 9(1):8, 2016. DOI:10.1186/s13041-016-0189-3 - Nomir AG., Takeuchi Y. et al.
Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1-Cre mice.
Genesis 54(7):379-388, 2016. DOI:10.1002/dvg.22951 - Nita A., Nishiyama M., Muto Y., Nakayama KI.
FBXL12 regulates T cell differentiation in a cell-autonomous manner.
Genes Cells 5:517-24, 2016. DOI:10.1111/gtc.12360 - Kitade S., Onoyama I., Kobayashi H., Yagi H., Yoshida S., Kato M., Tsunematsu R., Asanoma K., Sonoda K., Wake N., Hata K., Nakayama KI., Kato K.
FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors.
Cancer Sci. 107:1399-405, 2016. DOI:10.1111/cas.13026 - Hadano S, Mitsui S, Pan L, Otomo A, Kubo M, Sato K, Ono S, Onodera W, Abe K, Chen X, Koike M, Uchiyama Y, Aoki M, Warabi E, Yamamoto M, Ishii T, Yanagawa T, Shang H-F, Yoshii F.
Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.
Human Molecular Genetics 25:25, 2016. DOI:10.1093/hmg/ddw180 - Okamoto M, Nakayama Y, Kakihana A, Yuki R, Yamaguchi N, Yamaguchi N
Fyn Accelerates M Phase Progression by Promoting the Assembly of Mitotic Spindle Microtubules.
J Cell Biochem. 117(4):610-623, 2016. DOI:10.1002/jcb.25373 - Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M.
Generation of a new model rat: Nrf2 knockout rats are sensitive to aflatoxin B1 toxicity.
Toxicol Sci 152:40-52, 2016. DOI:10.1093/toxsci/kfw065 - Ishikawa T, Imamura K, Kondo T, Koshiba Y, Hara S, Ichinose H, Furujo M, Kinoshita M, Oeda T, Takahashi J, Takahashi R, Inoue H
Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders.
Hum Mol Genet 25:5188-5197, 2016. DOI:10.1093/hmg/ddw339 - Furuya M, Yao M, Tanaka R, Nagashima Y, Kuroda N, Hasumi H, Baba M, Matsushima J, Nomura F, Nakatani Y
Genetic, epidemiologic and clinicopathologic studies of Japanese Asian patients with Birt-Hogg-Dub? syndrome.
Clinical Genetics 90(5):403-412, 2016. DOI:10.1111/cge.12807 - Taki K, Ohmuraya M, Tanji E, Komatsu H, Hashimoto D, Semba K, Araki K, Kawaguchi Y, Baba H, Furukawa T.
GNAS(R201H) and Kras(G12D) Cooperate to Promote Murine Pancreatic Tumorigenesis Recapitulating Human Intraductal Papillary Mucinous Neoplasm.
Oncogene 35（18）:2407-2412, 2016. DOI:10.1038/onc.2015.294 - Futakuchi M, Fukamachi K, Suzui M
Heterogeneity of tumor cells in the bone microenvironment: mechanisms and therapeutic targets for bone metastasis of prostate or breast cancer.
Adv Drug Deliv Rev 99, 2016. DOI:10.1016/j.addr.2015.11.017 - Yoshikawa Y, Emi M, Hashimoto-Tamaoki T, Ohmuraya M, Sato A, Tsujimura T, Hasegawa S, Nakano T, Nasu M, Pastorino S, Szymiczek A, Bononi A, Tanji M, Pagano I, Gaudino G, Napolitano A, Goparaju C, Pass HI, Yang H, Carbone M.
High-density array-CGH With Targeted NGS Unmask Multiple Noncontiguous Minute Deletions on Chromosome 3p21 in Mesothelioma.
Proc Natl Acad Sci U S A. 113(47):13432-13437, 2016. DOI:10.1073/pnas.1612074113 - Wani S., Sugita A., Ohkuma Y., and Hirose Y.
Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation.
The Journal of Biochemistry 160(2):111-120, 2016. DOI:10.1093/jb/mvw018 - *Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D
Hypoxia and hypercapnia inhibit hypothalamic orexin neurons in rats.
Journal of Neurophysiology 116(5):2250-2259, 2016. DOI:10.1152/jn.00196.2016 - Kubo H, Shimono R*,Nakamura S, Koyano K,Jinnai W, Yamato S, Yasuda S, Nakamura M, Tanaka A, Fujii T, Kanenishi K, Chiba Y, Miki T, Kusaka T, Ueno M.
Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets.
Neonatology 111(3)::203-10, 2016. DOI:10.1159/000450721 - Tanaka M., Shiota M., Nakao T., Uemura R., Nishi S., Ohkawa Y., Matsumoto M., Yamaguchi M., Osada-Oka M., Inagaki A., Takahashi K., Nakayama KI., Gi M., Izumi Y., Miura K., Iwao H.
Identification of low-abundance proteins in serum via the isolation of HSP72 complexes.
J. Proteomics 136:214-21, 2016. DOI:10.1016/j.jprot.2016.01.008 - Ueno H.
Identification of normal and neoplastic stem cells by the multicolor lineage tracing method.
Pathology International 66(8):423-430, 2016. DOI:10.1111/pin.12425 - Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T and Sumiko Watanabe S
Identification of RNA-binding protein LARP4B as a tumor suppressor in glioma.
Cancer Res. 76(8):2254-2264, 2016. DOI:10.1158/0008-5472.CAN-15-2308 - Yoshinori Asano, Tatsuya Kawase, Atsushi Okabe, Shuichi Tsutsumi, Hitoshi Ichikawa, Satoko Tatebe, Issay Kitabayashi, Fumio Tashiro, Hideo Namiki, Tadashi Kondo, Kentaro Semba, Hiroyuki Aburatani, Yoichi Taya, Hitoshi Nakagama and Rieko Ohki
IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.
Scientific Reports 6:19174, 2016. DOI:10.1038/srep19174 - Tetsuhisa Otani, Yosuke Ogura, Kazuyo Misaki, Takuya Maeda, Akiyo Kimpara, Shigenobu Yonemura, Shigeo Hayashi
IKKε inhibits PKC to promote Fascin-dependent actin bundling.
Development 143:3806-3816, 2016. DOI:10.1242/dev.138495 - Shibata N, Kashima M, Ishiko T, Nishimura O, Rouhana L, Misaki K, Yonemura S, Saito K, Siomi H, Siomi MC, Agata K.
Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian.
Dev. Cell 37:226-37., 2016. DOI:10.1016/j.devcel.2016.04.009 - Ye X, Zhou Q, Matsumoto Y, Moriyama M, Kageyama S, Komatsu M, Satoh S, Tsuchida M, Saijo Y.
Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma.
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Integration of Organic Electrochemical and Field-Effect Transistors for Ultraflexible, High Temporal Resolution Electrophysiology Arrays.
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Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise: A study for specific neural control with Gi-DREADD in mice.
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Lack of Phenotypical and Morphological Evidences of Endothelial to Hematopoietic Transition in the Murine Embryonic Head during Hematopoietic Stem Cell Emergence.
PLoS One 11(5):e0156427, 2016. DOI:10.1371/journal.pone.0156427 - Maekawa T, Sasaoka T, Azuma S, Ichikawa T, Melrose HL, Farrer MJ, Obata F;
Leucine-rich repeat kinase 2 (LRRK2) regulates alpha-synuclein clearance in microglia.
BMC Neuroscience 17 (1):77, 2016. DOI:10.1186/s12868-016-0315-2 - Kanda M, Nagai T, Takahashi T, Liu ML, Kondou N, Naito AT, Akazawa H, Sashida G, Iwama A, Komuro I, Kobayashi Y.
Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction.
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Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
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Loss of Folliculin disrupts hematopoietic stem cell quiescence and homeostasis resulting in bone marrow failure.
Stem Cells 34(4):1068-1082, 2016. DOI:10.1002/stem.2293 - Sumiyoshi T, Sato K, Yamamoto H, Iwasaki YW, Siomi H, Siomi MC.
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Genes Dev. 30:1617-1622., 2016. DOI:10.1101/gad.283929.116 - Ichinose K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri S-Y, Iwamoto N, Tamai M, Arima K, Nakamura H, Obata Y, Yamamoto K, Origuchi T, Nishino T, Kawakami A and Tsokos GC
Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.
Arthritis and Rheumatology 68(4):944-952, 2016. DOI:10.1002/art.39499 - Saito M, Okumura K, Yoshizawa Y, Munakata H, Isogai E, and Wakabayashi Y.
Meis1 is required for c-Met inhibition to suppress cell proliferation of skin squamous cell carcinoma cells.
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MIF Maintains the Tumorigenic Capacity of Brain Tumor-Initiating Cells by Directly Inhibiting p53.
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MIP-1α/CCL3-expressing Basophil-Lineage Cells Drive the Leukemic Hematopoiesis of Chronic Myeloid Leukemia in Mice.
Blood 127:2607-2617, 2016. DOI:10.1182/blood-2015-10-673087 - Suzui M, Futakuchi M, Fukamachi K, Numano T, Abd Elgied M, Takahashi S, Ohnishi M, Omori T, Tsuruoka S, Hirose A, Kanno J, Sakamoto Y, Alexander DB, Xu J, Tsuda H
Multiwalled carbon nanotubes intratracheally instilletd into the rat lung induce development of pleural malignant mesothelioma and lung tumors.
Cancer Sci 107(7):924-935, 2016. DOI:10.1111/cas.12954 - Inaba H, Goto H, Kasahara K, Kumamoto K, Yonemura S, Inoko A, Yamano S, Wanibuchi H, He D, Goshima N, Kiyono T, Hirotsune S, Inagaki M.
Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.
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Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction.
Aging Cell 16(2):339-348, 2016. DOI:10.1111/acel.12558 - Kitamura, T., Watanabe-Okochi, N., Enomoto, Y., Nakahara, F., Oki, T., Komeno, Y., Kato, N., Doki, N., Uchida, T., Kagiyama, Y., Togami, K., Kawabata, K.C., Nishimura, K., Hayashi, Y., Nagase, R., Saika, M., Fukushima, T., Asada, S., Fujino, T., Izawa, Y., Horikawa, S., Fukuyama, T., Tanaka, Y., Ono, R., Goyama, S., Nosaka, T., Kitaura, J., and Inoue D.
Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).
J Biol Chem. 159:17-25, 2016. DOI:10.1093/jb/mvv114 - Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A and Hikida T.
Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage.
Learning and Memory 23 (7):359-64, 2016. DOI:10.1101/lm.042507.116 - Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M,?Ohmuraya?M, Sato T, Yoshimura SI, Sato K, Harada R, Kim YJ, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A.
Opposing Roles for SNAP23 in Secretion in Exocrine and Endocrine Pancreatic Cells.
J Cell Biol. 215（1）:121-138, 2016. DOI:10.1083/jcb.201604030 - Chowdhury S, *Yamanaka A
Optogenetic activation of serotonergic terminals facilitates GABAergic inhibitory input to orexin/hypocretin neurons.
Scientific reports 6:36039, 2016. DOI:10.1038/srep36039 - Hisha H, and Ueno H.
Organoid Culture of Lingual Epithelial Cells in a Three-Dimensional Matrix.
Methods in molecular biology 1576:93-99, 2016. DOI:10.1007/7651_2016_3 - Toyokuni S
Oxidative stress as an iceberg in carcinogenesis and cancer biology.
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p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith?Wiedemann syndrome.
J. Pathol. 239:250-61, 2016. DOI:10.1002/path.4721 - Saito, T., Waguri, S (38人中34番目)., *Komatsu, M (38人中38番目).
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.
Nat Commun 7, 2016. DOI:10.1038/ncomms12030 - Hatano A, Matsumoto M, Nakayama KI.
Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling.
Genes Cells 21:1095-112, 2016. DOI:10.1111/gtc.12406 - Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K.
Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons.
Mol. Cell 63:p1-12, 2016. DOI:10.1016/j.molcel.2016.06.008 - Umeda K, Ishizuka T, Yawo H, Shoji W.
Position- and quantity-dependent responses in zebrafish turning behavior.
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Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing.
Sci Rep 6:18844, 2016. DOI:10.1038/srep18844 - Lim, BC., Matsumoto, S., Yamamoto, H., Mizuno, H., Kikuta, J., Ishii, M., and Kikuchi, A
Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.
J. Cell Sci 129:3115-3129, 2016. DOI:10.1242/jcs.185439 - Guida V, Cernilogar FM, Filograna A, De Gregorio R, Ishizu H, Siomi MC, Schotta G, Bellenchi GC, Andrenacci D.
Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.
Genetics 204:631-644, 2016. DOI:10.1534/genetics.116.187922 - Honda T, Soeda S, Tsuda K, Yamaguchi C, Aoyama K, Morinaga T, Yuki R, Nakayama Y, Yamaguchi N, Yamaguchi N
Protective role for lipid modifications of Src-family kinases against chromosome missegregation.
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Protein Kinase D Regulates Positive Selection of CD4 + Thymocytes Through Phosphorylation of SHP-1.
Nat Commun. 7:12756, 2016. DOI:10.1038/ncomms12756 - 8. Toda, S., Iguchi, Y., Lin, Z., Nishikawa. H, Nagasawa, T., Watanabe, H., & Minabe, Y.
Reconsidering animal models of major depressive disorder in the elderly.
Frontiers in Aging Neuroscience 8:188, 2016. DOI:10.3389/fnagi.2016.00188 - Fujieda Y., Amengual O., Matsumoto M., Kuroki K., Takahashi H., Kono M., Kurita T., Otomo K., Kato M., Oku K., Bohgaki T., Horita T., Yasuda S., Maenaka K., Hatakeyama S., Nakayama KI., Atsumi T.
Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.
Rheumatology 55:1117-26, 2016. DOI:10.1093/rheumatology/kew005 - Kuribayashi H, Tsuhako A, Kikuchi M, Yoshida N, Koso H, Watanabe S
Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina.
Exp. Eye Res. 152:34-42, 2016. DOI:10.1016/j.exer.2016.09.005 - Chin DW, Sakurai M, Nah GS, Du L, Jacob B, Yokomizo T, Matsumura T, Suda T, Huang G, Fu XY, Ito Y, Nakajima H, Osato M.
RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.
Blood Cancer J. 6:e379, 2016. DOI:10.1038/bcj.2015.105 - Watabe, A.M., Nagase, M., Hagiwara, A., Hida, Y., Tsuji, M., Ochiai, T., Kato, F., Ohtsuka, T.
SAD-B Kinase regulates presynaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory.
Journal of Neurochemistry 136(1):36-47, 2016. DOI:10.1111/jnc.13379 - Meisler MH, Helman G, Hammer MF, Fureman BE, Gaillard WD, Goldin AL, Hirose S, Ishii A, Kroner BL, Lossin C, Mefford HC, Parent JM, Patel M, Schreiber J, Stewart R, Whittemore V, Wilcox K, Wagnon JL, Pearl PL, Vanderver A, Scheffer IE.
SCN8A encephalopathy: Research progress and prospects.
Epilepsia 57(7):1027-1035, 2016. DOI:10.1111/epi.13422 - Kimiko Shimizu, Yodai Kobayashi, Erika Nakatsuji, Maya Yamazaki, Shigeki Shimba, Kenji Sakimura & Yoshitaka Fukada
SCOP/PHLPP1b mediates circadian regulation of long-term recognition memory.
Nature Communications 7:12926, 2016. DOI:10.1038/ncomms12926 - Jun J. Nakano, Kimiko Shimizu, Shigeki Shimba & Yoshitaka Fukada
SCOP/PHLPP1β in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior.
Scientific Reports 6:33500, 2016. DOI:10.1038/srep33500 - Yang H, Ni HM, Guo F, Ding Y, Shi YH, Lahiri P, Fr?hlich LF, R?licke T, Smole C, Schmidt VC, Zatloukal K, Cui Y, Komatsu M, Fan J, Ding WX.
Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice.
J Biol Chem. 291:18663-18674, 2016. DOI:10.1074/jbc.M116.739821 - Takamura, S., Yagi, H., Hakata, Y., Motozono, C., McMaster, SR., Tomura, M., Nakayama, T., Woodland, DL., Kohlmeier, JE., Miyazawa, M.
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
J Exp Med. 213:3057-3073, 2016. DOI:10.1084/jem.20160938 - Habisov, S., Huber, J., Ichimura, Y., Akutsu, M., Rogova, N., Loehr, F., McEwan, D.G., Johansen, T., Dikic, I., Doetsch, V., Komatsu, M., Rogov, V.V., *Kirkin, V.
Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.
J Biol Chem 291:9025-9041, 2016. DOI:10.100xxx2/ejoc.201601023 - Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, Nureki O.
Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.
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Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala.
Journal of Neurophysiology 115:2721-2739, 2016. DOI:10.1152/jn.00946.2015 - Yasuda D, Nakajima M, Yuasa A, Obata R, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.
Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity.
Bioorg Med Chem Lett 26:5956-5959, 2016. DOI:10.1016/j.bmcl.2016.10.083 - Katsushima K, Natsume A, Ohka F, Shinjo K, Hatanaka A, Ichimura N, Sato S, Takahashi S, Kimura H, Totoki Y, Shibata T, Naito M, Kim HJ, Miyata K, Kataoka K, Kondo Y.
Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment.
Nat Commun 7:13616-, 2016. DOI:10.1038/ncomms13616 - Fuchs H, Sabrautzki S, Przemeck G, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, O?stereicher M, Hans W, Abe K et al.
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.
G3・Genes| Genomes| Genetics 6:4035-4046, 2016. DOI:10.1534/g3.116.033670 - Inutsuka A, Yamashita A, Chowdhury S, Nakai J, Ohkura M, Taguchi T, *Yamanaka A
The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation.
Scientific reports 6:29480, 2016. DOI:10.1038/srep29480 - Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A.
The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.
J Exp Med 213(8):1459-1477, 2016. DOI:10.1084/jem.20151121 - Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S.
The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.
J. Mol. Cell. Cardiol. 100:43-53, 2016. DOI:10.1016/j.yjmcc.2016.09.013 - Toyokuni S
The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy.
Pathology International 66:245-259, 2016. DOI:10.1111/pin.12396 - Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C, Hirao A.
Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance.
J Biol Chem. 291:21496-21509, 2016. DOI:10.1074/jbc.M116.734756 - Takeishi S., Nakayama KI.
To wake up cancer stem cells, or to let them sleep, that is the question.
Cancer Sci. 107:875-81, 2016. DOI:10.1111/cas.12958 - Miyamoto D,?Hirai D,?Fung CC,?Inutsuka A,?Odagawa M,?Suzuki T,?Boehringer R,?Adaikkan C,?Matsubara C,?Matsuki N,?Fukai T,?McHugh TJ,Yamanaka A,?*Murayama M
Top-down cortical input during NREM sleep consolidates perceptual memory.
Science 352(6291):1315-1318, 2016. DOI:10.1126/science.aaf0902 - Eisuke Sato, Yurika Tanabe, Naoya Nakajima, Akifumi Ohkubo, and Kiyotake Suenaga
Total Synthesis of Biselyngbyolide B.
Organic Letters 18 (9):2047-2049, 2016. DOI:10.1021/acs.orglett.6b00660 - Ju J, Hirose S, Shi XY, Ishii A, Hu LY, Zou LP.
Treatment with Oral ATP decreases alternating hemiplegia of childhood with de novo ATP1A3 Mutation.
Orphanet Journal of Rare Diseases. 11(1):55, 2016. DOI:10.1186/s13023-016-0438-7 - Inoue, D., Nishimura, K., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K-I. and Kitamura, T
Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.
Experimental Hematology 44:172 -176, 2016. DOI:10.1016/j.exphem.2015.11.011 - Takaori T, Kumakura A, Ishii A, Hirose S, Hata D.
Two mild cases of Dravet syndrome with truncating mutation of SCN1A.
Brain & Development 39(1):72-74, 2016. DOI:10.1016/j.braindev.2016.07.006 - Takatoshi Iijima, Chiharu Hidaka and Yoko Iijima.
Update Article: Spatio-temporal regulations and functions of neuronal alternative RNA splicing in developing and adult brains.
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Versatile function of the circadian protein CIPC as a regulator of Erk activation.
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WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
FASEB J 30(4):1534-1547, 2016. DOI:10.1096/fj.15-280313 - Matsumoto, S., Kurimoto, T., Taketo, M., Fujii, S., and Kikuchi, A
Wnt-Myb pathway suppresses KIT expression to control the timing of salivary proacinar differentiation and duct formation.
Development 143(13):2311-2324, 2016. DOI:10.1242/dev.134486 - 山中章弘
オレキシンを中心とした睡眠覚醒調節の神経機構.
高齢者の睡眠とその障害 :221-228, 2016. - 蛯原功介、山中章弘
オレキシン受容体の関連物質をターゲットとした臨床応用.
Clinical Neuroscience 34(7):740-741, 2016. - 山中章弘
オレキシン受容体の種類.
Clinical Neuroscience 34(5):496-497, 2016. - 山下貴之、山中章弘
オレキシン受容体の生理的および薬理的機能.
Clinical Neuroscience 34(6):612-613, 2016. - 小川宏人
昆虫の短中距離ナビゲーションを支える神経基盤.
日本ロボット学会誌 34:685-689, 2016. DOI:10.7210/jrsj.34.685 - 渡邉 貴樹, 上阪 直史, 狩野 方伸
生後発達期の小脳におけるシナプス刈り込みのメカニズム.
生化学 88(5):621-629, 2016. DOI:10.14952/SEIKAGAKU.2016.880621 - 山本一男
哺乳類の細胞サイズを規定する分子基盤.
実験医学 34(15):2615-2620, 2016.
