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成果論文リスト

本支援による成果を含む論文として支援依頼者から報告があった論文を成果が得られた年度順に並べました。成果論文には「先端モデル動物支援」の課題番号「22H04922」を謝辞に入れることをお願いしていますが、課題番号の記載がない論文も含めています。

2020年度

  1. Shutoh F, Masuda T, Sasaki T, Takei Y.
    Anomalous atrium associated with persistent left superior vena cava.
    Anatomical Science International. -:2021, 1-5. DOI:10.1007/s12565-021-00604-z
  2. Asano T, Teh DBL, Yawo H.
    Application of Optogenetics for Muscle Cells and Stem Cells.
    Adv Exp Med Biol. 1293:2021, 359-375. DOI:10.1007/978-981-15-8763-4_23
  3. M. Sumiyoshi, Y. Kotani, Y. Ikuta, K. Suzue, M. Ozawa, T. Katakai, T. Yamada, T. Abe, K. Bando, S. Koyasu, Y. Kanaho, T. Watanabe and S. Matsuda
    Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation.
    The Journal of Immunology 206:2021, 366-375. DOI:10.4049/jimmunol.2000971
  4. Ishida A, Igarashi K, Ruike Y, Ishiwata K, Naito K, Kono S, Deguchi H, Fujimoto M, Shiga A, Suzuki S, Yoshida T, Tanaka T, Tatsuno I, Yokote K, Koide H.
    Association of urinary free cortisol with bone formation in patients with mild autonomous cortisol secretion.
    Clin Endocrinol (Oxf). 94:2021, 544-550. DOI:10.1111/cen.14385
  5. Fujihara K, Sato T, Higeta K, Miyasaka Y, Mashimo T, Yanagawa Y.
    Behavioral consequences of a combination of Gad1 haplodeficiency and adolescent exposure to NMDA receptor antagonist in Long-Evans rat.
    Front Pharmacol. 12:2021, 646088. DOI:10.3389/fphar.2021.646088
  6. Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Maenaka K, Shimada T, Fukata M, Nishijo H, Takao K, Okabe S, Tabuchi K, Mishina M, Mori H, Fukai S.
    Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.
    Nature Communications 12(1):2021, 1848. DOI:10.1038/s41467-021-22059-6
  7. Adhikara IM, Yagi K, Mayasari DS, Suzuki Y, Ikeda K, Ryanto GRT, Sasaki N, Rikitake Y, Nadanaka S, Kitagawa H, Miyata O, Igarashi M, Hirata K, Emoto N
    Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
    Arterioscler Thromb Vasc Biol 41(3):2021, 1076-1091. DOI:10.1161/ATVBAHA.120.315789
  8. Fumito Ishibashi, Tsutomu Fukuda, Shijiao Zha, Aya Hashirano, Shotaro Hirao, Masatomo Iwao
    Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin.
    Bioscience, Biotechnology, and Biochemistry 85:2021, 181-191. DOI:10.1093/bbb/zbaa028
  9. Sasaki T, Takei Y.
    Constitutive increase of IL-17A in serum affects microglial activity in the hippocampal dentate gyrus.
    Jap J Biol Psych. 32(2):2021, in press.
  10. Shimizu T, Takahashi N, Huber VJ, Asawa Y, Ueda H, Yoshimori A, Muramatsu Y, Seimiya H, Kouji H, Nakamura H, Oguri H.
    Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α.
    Bioorg Med Chem. 30:2021, 115949. DOI:10.1016/j.bmc.2020.115949
  11. Doi H, Parajuli B, Horio T, Shigetomi E, Shinozaki Y, Noda T, Takahashi K, Hattori T, Koizumi S, Sawada K
    Development of a label-free ATP image sensor for analyzing spatiotemporal patterns of ATP release from biological tissues.
    Sensors and Actuators B: Chemical 335:2021, 129686. DOI:10.1016/j.snb.2021.129686
  12. Suzuki T, Ogita H, Sato A, Minamidate N, Hachiro K.
    Differences between atherosclerotic and non-atherosclerotic patients in expression levels of inflammatory mediators in the adipose tissue around the coronary artery.
    Int Heart J -:2021, in press. DOI:10.1536/ihj.20-585
  13. Katagiri T, Ushiki T, Nakajima-Takagi Y, Oshima M, Mikami T, Kawasaki A, Ishiguro H, Tanaka T, Sone H, Kitagawa H, Igarashi M, Iwama A, Masuko M
    Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis.
    Exp Hematol 96:2021, 52-62. DOI:10.1016/j.exphem.2021.02.003
  14. Tsutomu Fukuda, Seiya Okutani, Mayu Sumi, Kazuhito Miyagi, Gen Onodera, Masanari Kimura
    Divergent Total Synthesis of Azalamellarins D and N.
    Heterocycles 103:2021, in press. DOI:10.3987/COM-20-S(K)53
  15. Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K.
    Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons.
    Biomedicines 9 (1):2021, E49. DOI:10.3390/biomedicines9010049
  16. Ito, N., Riyadh, M., Ahmad, S., Hattori, S., Miyakawa, T. and Ohta, K. et al.
    Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice.
    Science Translational Medicine 13(587):2021, eaay7896. DOI:10.1126/scitranslmed.aay7896
  17. Sasaki T, Nagata R, Takahashi S, Takei Y
    Effects of RORγt overexpression on the murine central nervous system.
    Neuropsychopharmacology Reports -:2021, 1-9. DOI:10.1111/NPR2.12162
  18. Hikmawan Wahyu Sulistomo, Takayuki Nemoto, Yohko Kage, Hajime Fujii, Taku Uchida, Kogo Takamiya, Hideki Sumimoto, Hiroaki Kataoka, Haruhiko Bito, Ryu Takeya
    Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.
    Cerebral Cortex -:2021, in press. DOI:10.1093/cercor/bhaa355
  19. Fujihara K, Sato T, Miyasaka Y, Mashimo T, Yanagawa Y.
    Genetic deletion of the 67-kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats.
    FEBS Open Bio. -:2021, in press. DOI:10.1002/2211-5463.13065
  20. Sumitani M, Nishizawa D, Hozumi J, Ikeda K.
    Genetic implications in quality palliative care and preventing opioid crisis in cancer-related pain management.
    Journal of Neuroscience Research -:2021, in press. DOI:10.1002/jnr.24756
  21. Natsumeda M, Miyahara H, Yoshimura J, Okada M, Hirato J, Wataya T, Tateishi K, Rodriguez FJ, Suva ML, Taylor MD, Eberhart CG, Fujii Y, Kakita A
    GLI3 is associated with neuronal differentiation in SHH-activated and WNT-activated medulloblastoma.
    Journal of Neuropathology and Experimental Neurology 80(2):2021, 129-136. DOI:10.1093/jnen/nlaa141
  22. Miyata S, Kakizaki T, Fujihara K, Obinata H, Hirano T, Nakai J, Tanaka M, Itohara S, Watanabe M, Tanaka KF, Abe M, Sakimura K, Yanagawa Y.
    Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice.
    Mol Brain. 14:2021, 5. DOI:10.1186/s13041-020-00713-2
  23. Matsumoto K, Okamoto K, Okabe S, Fujii R, Ueda K, Ohashi K, Seimiya H.
    G-quadruplex-forming nucleic acids interact with SF3B2 and suppress innate immune gene expression.
    Genes Cells 26:2021, 65-82. DOI:10.1111/gtc.12824
  24. Dat NQ, Oikawa D, Yoishizato K, Tokunaga F, Pinzani M, Kawada M, et al.
    His-Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
    Hepatology. -:2021, in press.
  25. Kumiko Naito,Sawako Suzuki,Chikako Ohwada,Jun-ichiro Ikeda,Tomoaki Tanaka,Koutaro Yokote.
    ICAM1-Negative Intravascular Large B-Cell Lymphoma of the Pituitary Gland: A Case Report and Literature Review.
    AACE Clinical Case Reports -:2021, in press. DOI:10.1016/j.aace.2021.01.011
  26. Aoki H, Abe C, Hara A, Miyazaki T, Morita H, Kunisada T.
    Induced genetic ablation of Rest leads to the alteration of stimulus-induced response of the vagal nerve.
    Genes Cells. 26(2):2021, 45-55. DOI:10.1111/gtc.12819
  27. Toshinori Matsuoka, Miwako Yamasaki, Manabu Abe, Yukiko Matsuda, Hiroyuki Morino, Hideshi Kawakami, Kenji Sakimura, Masahiko Watanabe, Kouichi Hashimoto
    Kv11 (ether-à-go-go-related gene) voltage-dependent K+ channels promote resonance and oscillation of subthreshold membrane potentials.
    Journal of Physiology (London) 599:2021, 547-569. DOI:10.1113/JP280342
  28. Nishiya N, Oku Y, Ishikawa C, Fukuda T, Dan S, Mashima T, Ushijima M, Matsuura M, Tomida A, Seimiya H, Yamori T, Iwao M, Uehara Y et al.
    Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor.
    Cancer Sci. -:2021, in press. DOI:10.1111/cas.14839
  29. T Shimizu, K Kimura, E Sugihara, S Yamaguchi‐Iwai, H Nobusue, O Sampetrean, Y Otsuki, Y Fukuchi, K Saitoh, K Kato, T Soga, A Muto, H Saya
    MEK inhibition preferentially suppresses anchorage‐independent growth in osteosarcoma cells and decreases tumors in vivo.
    Journal of Orthopaedic Research -:2021, in press. DOI:10.1002/jor.25023
  30. Asada-Utsugi M, Uemura K, Noda Y, 他8名, Takahashi R, Hattori S, Miyakawa T, Ageta-Ishihara N, Kobayashi K, Kinoshita M, Kinoshita A.
    Mice with a cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial memory tasks.
    Molecular Brain 14(1):2021, 23. DOI:10.1186/s13041-021-00738-1
  31. Tesshu Hori, Shohei Ikuta, Satoko Hattori, Keizo Takao, Tsuyoshi Miyakawa, Chieko Koike
    Mice with mutations in Trpm1, a gene within the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior.
    Molecular Brain 14(1):2021, 61. DOI:10.1186/s13041-021-00749-y
  32. Mushiake H, Ohshiro T, Osawa SI, Hosaka R, Katayama N, Tanaka T, Yawo H, Osanai M.
    Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits.
    Adv Exp Med Biol. 1293:2021, 501-509. DOI:10.1007/978-981-15-8763-4_34
  33. Arima Y, Nakagawa Y, Takeo T, Ishida T, Yamada T, Hino S, Yamagata K, Nakamura T, Nakagata N, Tsujita K
    Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.
    Nature Metabolism 3:2021, 196-210. DOI:10.1038/s42255-021-00342-6
  34. Aki Takahashi, Hossein Aleyasin, Tetsuya Sasaki, Sonoko Ogawa, Bruce S. McEwen and Scott J. Russo et al
    Neuromodulatory effect of interleukin 1 in the dorsal raphe nucleus on individual differences in aggression.
    Molecular Psychiatry -:2021, in press.
  35. Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Matsumoto H, Miyakawa T, Nakada K.
    Neuronal degeneration and cognitive impairment can be prevented via the normalization of mitochondrial dynamics.
    Pharmacol Res. 163:2021, 105246. DOI:10.1016/j.phrs.2020.105246
  36. Tatsuya Yamahira, Gen Onodera, Tsutomu Fukuda, Masanari Kimura
    Ni-catalyzed direct carboxylation of propargylic alcohols with carbon dioxide.
    Chemistry Letters -:2021, in press. DOI:10.1246/cl.210008
  37. Ying Luo, Bun Chan, Tsutomu Fukuda, Gen Onodera, Masanari Kimura
    Nickel-​Catalyzed Carboxylation of Conjugated Dienes with Carbon Dioxide and DIBAL-​H for the Synthesis of β,​γ-​Unsaturated Carboxylic Acids.
    Synlett -:2021, in press. DOI:10.1055/a-1336-8034
  38. Mori T, Kido A, Kawahara I, Nukaga S, Miyagawa Y, Goto K, Mori S, Kishi S, Fujii K, Fujiwara-Tani R, Kuniyasu H
    Nutritional intervention for cancer sarcopenia.
    Ann Muscloskeletal Med 5(1):2021, 001-004. DOI:10.17352/amm.000024
  39. Akira C Saito, Tomohito Higashi, Yugo Fukazawa, Tetsuhisa Otani, Masashi Tauchi, Atsuko Y Higashi, Mikio Furuse, Hideki Chiba
    Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function.
    Molecular biology of the cell -:2021, in press. DOI:10.1091/mbc.E20-07-0464
  40. Ando S, Fukamachi K, Yoshimoto E, Matsumoto H, Iinuma M and Suzui M.
    Palmitoyl piperidinopiperidine, a novel derivative of 10-hydroxy-2-decenoic acid, as a potent and selective anticancer agent against human colon carcinoma cell lines.
    Int J Oncol 58:2021, 251-265. DOI:10.3892/ijo.2020.5160
  41. Okada M, Kawagoe Y, Sato Y, Nozumi M, Ishikawa Y, Tamada A, Yamazaki H, Sekino Y, Kanemura Y, Shinmyo Y, Kawasaki H, Kaneko N, Sawamoto K, Fujii Y, Igarashi M
    Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates.
    Mol Brain 14(1):2021, 66. DOI:10.1186/s13041-021-00755-0
  42. Hayashi T
    Post-translational palmitoylation of ionotropic glutamate receptors in excitatory synaptic functions.
    British Journal of Pharmacology 178:2021, 784-797. DOI:10.1111/bph.15050
  43. Shinozaki Y, Koizumi S
    Potential role of astrocytes and Muller cells in the pathogenesis of glaucoma.
    Journal of Pharmacological Sciences 145:2021, 262-267. DOI:10.1016/j.jphs.2020.12.009
  44. H. Igata, Y. Ikegaya, T. Sasaki
    Prioritized experience replays on a hippocampal predictive map for learning.
    Proceedings of the National Academy of Sciences of the United States of America 118:2021, e2011266118. DOI:10.1073/pnas.2011266118
  45. Kakizaki T, Ohshiro T, Itakura M, Konno K, Watanabe M, Mushiake H, Yanagawa Y.
    Rats deficient in the GAD65 isoform exhibit epilepsy and premature lethality.
    FASEB J. 35(2):2021, e21224. DOI:10.1096/fj.202001935R
  46. Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, Sugita K, Aihara M, Koizumi S.
    Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
    JCI Insight -:2021, in press. DOI:10.1172/jci.insight.135391
  47. Johmura Y, Nakanishi M, et al
    Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.
    Science 371(6526):2021, 265-270. DOI:10.1126/science.abb5916
  48. K.Hikita, Y.Yamakage, H.Okunaga, Y.Motoyama, H.Matsuyama, K.Matsuoka, T.Murata, T.Nakayoshi, A.Oda, K.Kato, H.Tanaka, N.Asao, S.Dan and N.Kaneda
    (S)-erypoegin K, an isoflavone isolated from Erythrina poeppigiana, is a novel inhibitor of topoisomerase IIα: Induction of G2 phase arrest in human gastric cancer cells .
    Bioorg. Med. Chem. 30:2021, 115904. DOI:10.1016/j.bmc.2020.115904
  49. Rahman NIA, Sato A, Tsevelnorov K, Shimizu A, Komeno M, Ahmat Amin MKB, Molla MR, Soh JEC, Nguyen LKC, Wada A, Kawauchi A, Ogita H.
    Stomatin-mediated inhibition of the Akt signaling axis suppresses tumor growth.
    Cancer Res -:2021, in press. DOI:10.1158/0008-5472.CAN-20-2331
  50. Tsutomu Fukuda, Fumito Ishibashi, Yusuke Oku, Naoyuki Nishiya, Yoshimasa Uehara, Masatomo Iwao
    Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant.
    Bioorganic & Medicinal Chemistry 34:2021, 116039. DOI:10.1016/j.bmc.2021.116039
  51. Taguchi K, Yamamoto M
    The KEAP1-NRF2 system as a molecular target of cancer treatment.
    Cancers 13:2021, 46. DOI:10.3390/cancers13010046
  52. Yamamura R, Ooshio T & Sonoshita M.
    Tiny Drosophila makes giant strides in cancer research.
    Cancer Sci 112:2021, 505-514. DOI:10.1111/cas.14747
  53. Yusuke Araki, Yusuke Hanaki, Masaki Kita, Koutaro Hayakawa, Kazuhiro Irie, Yoshihiko Nokura, Atsuo Nakazaki, and Toshio Nishikawa
    Total Synthesis and Biological Evaluation of Oscillatoxin D, E, and F.
    Bioscience, Biotechnology, and Biochemistry -:2021, in press. DOI:10.1093/bbb/zbab042
  54. Parajuli B, Saito H, Shinozaki Y, Shigetomi E, Miwa H, Yoneda S, Tanimura M, Omachi S, Asaki T, Takahashi K, Fujita M, Nakashima K, Koizumi S
    Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.
    GLIA -:2021, in press.
  55. Chikuma S, Yamanaka S, Nakagawa S, Ueda MT, Hayabuchi H, Tokifuji Y, Kanayama M, Okamura T, Arase H, Yoshimura A
    TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus.
    The Journal of Immunology -:2021, in press. DOI:10.4049/jimmunol.2001003
  56. Miyajima K, Kawamoto C, Hara S, Mori-Kojima M, Ohye T, Sumi-Ichinose C, Saito N, Sasaoka T, Metzger D, Ichinose H
    Tyrosine hydroxylase conditional knockout mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways.
    Journal of Biological Chemistry -:2021, 100544. DOI:10.1016/j.jbc.2021.100544
  57. Huizi Keiko Li, Yukie Morokoshi, Satoshi Kodaira, Tamon Kusumoto, Katsuyuki Minegishi, Hiroaki Kanda, Kotaro Nagatsu, and Sumitaka Hasegawa
    Utility of 211At-trastuzumab for the Treatment of Metastatic Gastric Cancer in the Liver: Evaluation of a Preclinical α-Radioimmunotherapy Approach in a Clinically-relevant Mouse Model.
    Journal of Nuclear Medicine -:2021, in press. DOI:10.2967/jnumed.120.249300
  58. 田口恵子、山本雅之
    環境応答・適応の分子機構.
    日本体質医学学会誌 83:2021, in press.
  59. Yuichiro Koga, Daisuke Tsuchimoto, Yoshinori Hayashi, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Hiroshi Nakanishi, Shinya Toyokuni, Yusaku Nakabeppu
    Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy.
    JCI Insight 5(22):2020, e140229. DOI:10.1172/jci.insight.140229
  60. Ichikawa J, Ando T, Kawasaki T, Sasaki T, Shirai T, Tsukiji N, Kimura Y, Aoki K, Hayakawa K, Suzuki-Inoue K, Saitoh M, Haro H.
    Role of Platelet C-Type Lectin-Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma.
    J Bone Miner Res 35(9):2020, 1738-1750. . DOI:10.1002/jbmr.4045
  61. Kataura T, Tashiro E, Nishikawa S, Onodera M, Shin-ya K, et al Sasazawa Y, Hattori N, Saiki S, and Imoto M
    A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
    Autophagy -:2020, in press. DOI:10.1080/15548627.2020.1794590
  62. M. Endoh, M. Baba, T. Endoh, A. Hirayama, A. Nakamura-Ishizu, T. Umemoto, M. Hashimoto, K. Nagashima, T. Soga, M. Lang, L.S. Schmidt, W.M. Linehan, T. Suda
    A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity.
    Cell Reports 30:2020, 1823 - 1834. DOI:10.1016/j.celrep.2020.01.042
  63. Koi H, Takahashi N, Fuchi Y, Umeno T, Muramatsu Y, Seimiya H, Karasawa S, Oguri H.
    A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities.
    Org Biomol Chem. 18:2020, 5339-5343. DOI:10.1039/d0ob00919a
  64. Masumichi Saito, Hiroo Hasegawa, Shunsuke Yamauchi, et al.
    A high‑throughput detection method for the clonality of Human T‑cell leukemia virus type‑1‑infected cells in vivo.
    International Journal of Hematology 112(3):2020, 300-306. DOI:10.1007/s12185-020-02935-5
  65. Takahashi H, Yamanaka S, Kuwada S, Higaki K, Kido K, Sato Y, Fukai S, Tokunaga F, Sawasaki T.
    A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors.
    Biomedicines 8:2020, 152. DOI:10.3390/biomedicines8060152
  66. Eura N, Matsui TK, ..Kuniyasu H, Nagamori S, Muotri AR, Shin JW, Sugie K, Mori E
    A human neurodevelopmental disease model using human brainstem organoids - Brainstem organoids from human pluripotent stem cells.
    Front Neurosci 14:2020, 538. DOI:10.3389/fnins.2020.00538
  67. Masanori Kawabata, Shogo Soma, Akiko Saiki-Ishikawa, Satoshi Nonomura, Junichi Yoshida, Alain A Ríos, Yutaka Sakai, Yoshikazu Isomura
    A spike analysis method for characterizing neurons based on phase locking and scaling to the interval between two behavioral events.
    Journal of Neurophysiology 124:2020, 1923-1941. DOI:10.1152/jn.00200.2020
  68. Tsuboyama K., Osaki T., Matsuura-Suzuki E., Kozuka-Hata H., Okada Y., Oyama M., Ikeuchi Y., Iwasaki S., and Tomari Y.
    A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation.
    PLoS Biol. 18(3):2020, e3000632. DOI:10.1371/journal.pbio.3000632
  69. Kobayashi K, Endoh F, Ohmori I, Akiyama T.
    Action of antiepileptic drugs on neurons.
    Brain Dev. 42(1):2020, 2-5. DOI:10.1016/j.braindev.2019.07.006
  70. Kawakami R, Mashima T, Kawata N, Kumagai K, Migita T, Sano T, Mizunuma N, Yamaguchi K, Seimiya H.
    ALDH1A3-mTOR axis as a therapeutic target for anticancer drug-tolerant persister cells in gastric cancer.
    Cancer Sci. 111:2020, 962-973. DOI:10.1111/cas.14316
  71. Gotoh N, Saito Y, Hata S, Saito H, Ojima D, Murayama C, Shigeta M, Abe T, Konno D, Matsuzaki F, Suzuki T, Yamamoto T
    Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α-deficient mice.
    Journal of Biological Chemistry 295:2020, 9650-9662. DOI:10.1074/jbc.RA119.012386
  72. Mori S, Kishi S, Honoki K, Fujiwara-Tani R, Moriguchi T, Sasaki T, Fujii K, Tsukamoto S, Fujii H, Kido A, Tanaka Y, Luo Y, Kuniyasu H
    Anti-stem cell property of pterostilbene in gastrointestinal cancer cells.
    Int J Mol Sci 21:2020, 9347. DOI:10.3390/ijms21249347
  73. Tsunematsu T, Arakaki R, Kawai H, Ruppert J, Tsuneyama K, Ishimaru N, Earnshaw WC, Pagano M, Kudo Y.
    APC/C-Cdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit.
    Journal of Cell Science 133(18):2020, jcs251314. DOI:10.1242/jcs.251314
  74. Tetsuro Kawazoe, Hiroshi Saeki, Eiji Oki, Yoshinao Oda, Yoshihiko Maehara, Masaki Mori, Koji Taniguchi
    Autocrine Leukemia Inhibitory Factor Promotes Esophageal Squamous Cell Carcinoma Progression via Src Family Kinase-Dependent Yes-Associated Protein Activation.
    Molecular Cancer Research 18:2020, 1876-1888. DOI:10.1158/1541-7786.MCR-20-0186
  75. Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Murakami M, Tanaka T, Goda W, Hashimoto T, Miyakawa T, Iwatsubo T, Hata J, Niikura T, Yasui M et al.
    Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model.
    Acta Neuropathol. Commun. 8:2020, 67. DOI:10.1186/s40478-020-00936-3
  76. Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Hirashima M, Suzuki Y, Furuya M, Baba M, Kubota Y
    Blood and lymphatic systems are segregated by the FLCN tumor suppressor.
    Nature Communications volume 11:2020, 6314. DOI:10.1038/s41467-020-20156-6
  77. Kariba Y, Yoshizawa T, Sato Y, Tsuyama T, Araki E, Yamagata K
    Brown adipocyte-derived miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes.
    Biochem Biophys Res Commun 530:2020, 500-507. DOI:10.1016/j.bbrc.2020.05.090
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    Scientific Reports 10:2020, 10094. DOI:10.1038/s41598-020-67116-0
  160. Christian Hartmann, Ysabel Alessa Schwietzer, Tetsuhisa Otani, Mikio Furuse, Klaus Ebnet
    Physiological functions of junctional adhesion molecules (JAMs) in tight junctions.
    Biochimica et biophysica acta. Biomembranes 1862(9):2020, 183299-183299. DOI:10.1016/j.bbamem.2020.183299
  161. Onishi R, Sato K, Murano K, Negishi L, Siomi H, Siomi MC.
    Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells.
    Sci. Adv. 6:2020, eaaz7420. DOI:10.1126/sciadv.aaz7420
  162. Ohi K, Nishizawa D, Muto Y, Sugiyama S, Hasegawa J, Soda M, Kitaichi K, Hashimoto R, Shioiri T, Ikeda K
    Polygenic Risk Scores for Late Smoking Initiation Associated with the Risk of Schizophrenia.
    NPJ Schizophr 6(1):2020, 36. DOI:10.1038/s41537-020-00126-z
  163. Kuroiwa Y, Nakayama J, Adachi C, Inoue T, Watanabe S and Semba K
    Proliferative Classification of intracranially injected HER2-positive Breast Cancer Cell Lines.
    Cancers 12:2020, 1-18. DOI:10.3390/cancers12071811
  164. Mito M, Mishima Y, and Iwasaki S
    Protocol for disome profiling to survey ribosome collision in humans and zebrafish.
    STAR Protoc. 1(3):2020, 100168 . DOI:10.1016/j.xpro.2020.100168
  165. Kuniyasu H
    Pterostilbene in Gastrointestinal Cancer Cells.
    MDPI Scholarly Community Encyclopedia-Topic Review 2020:2020, 1-3.
  166. Taishi Kobayashi, Takuro Murakami, Yuu Hirose, and Toshihiko Eki
    Purification and characterization of double-stranded nucleic acid-dependent ATPase activities of tagged Dicer-related helicase 1 and its short isoform in Caenorhabditis elegans.
    Genes 11:2020, 734. DOI:10.3390/genes11070734
  167. Matsuki Y, Matsuo Y, Nakano Y, Iwasaki S, Yoko H, Udagawa T, Li S, Saeki Y, Yoshihisa T, Tanaka K, Ingolia NT, and Inada T.
    Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome.
    Sci Rep 10(1):2020, 19669. DOI:10.1038/s41598-020-76239-3
  168. Kunishige H, Migita K, Matsumoto S, Wakatsuki K, Nakade H, Miyao S, Kuniyasu H, Sho M
    Ring box protein-1 is associated with a poor prognosis and tumor progression in esophageal cancer.
    Oncol Lett 20:2020, 2919-2927. DOI:10.3892/ol.2020.11840
  169. Chu J, Deyama S, Li X, Motono M, Otoda A, Saito A, Esaki H,Nishitani N, Kaneda K
    Role of 5-HT1A receptor-mediated serotonergic transmission in the medial prefrontal cortex in acute restraint stress-induced augmentation of rewarding memory of cocaine in mice.
    Neuroscience Letters 743:2020, 135555. DOI:10.1016/j.neulet.2020.135555
  170. Fujiwara-Tani R, Fujii K, Mori S, Kishi S, Sasaki T, Ohmori H, Nakashima C, Kawahara I, NishiguchiY, Mori T, Sho M, Kondoh M, Luo Y, Kuniyasu H
    Role of Clostridium perfringens enterotoxin on YAP activation in colonic sessile serrated adenoma/polyp with dysplasia.
    Int J Mol Sci 21(11):2020, E3840. DOI:10.3390/ijms21113840
  171. Owari T, Takamitsu Sasaki T, Fujii K, Fujiwara-Tani R, Kishi S, Mori S, Mori T, Goto K, Kawahara I, ...Luo Y, Tanaka N, Kondoh M, Fujimoto K, Kuniyasu H
    Role of nuclear claudin-4 in renal cell carcinoma.
    Int J Mol Sci 21:2020, 8340. DOI:10.3390/ijms21218340
  172. Fukai S, Yoshida T.
    Roles of type-IIa receptor protein tyrosine phosphatases as synaptic organizers.
    FEBS Journal -:2020, in press. DOI:10.1111/febs.15666
  173. T Nakayama, K Okimura, J Shen, YJ Guh, 中略, K Nakayama, N Shiina, N Yamamoto, AS Loudon, T Nishiwaki-Ohkawa, A Shinomiya, T Nabeshima, Y Nakane and T Yoshimura
    Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior.
    Proc. Natl. Acad. Sci. U.S.A. 117:2020, 9594 - 9603. DOI:10.1073/pnas.2000278117
  174. Aonuma H.
    Serotonergic control in initiating defensive responses to unexpected tactile stimuli in the trap-jaw ant Odontomachus kuroiwae.
    Journal of Experimental Biology 223(Pt 19):2020, jeb228874. DOI:10.1242/jeb.228874
  175. Yokoi S, Naruse K, Kamei Y, Ansai S, Kinoshita M, Mito M, Iwasaki S., Inoue S, Okuyama T, Nakagawa S, Young LJ, and Takeuchi H.
    Sexually dimorphic role of oxytocin in medaka mate choice.
    Proc Natl Acad Sci USA. 117(9):2020, 4802-4808. DOI:10.1073/pnas.1921446117
  176. Tomita I, Kume S, Sugahara S, .., Ogita H, Araki SI, Maegawa H.
    SGLT2 inhibition mediates protection from diabetic kidney disease by promoting ketone body-induced mTORC1 inhibition.
    Cell Metab. 32:2020, 404-419. DOI:10.1016/j.cmet.2020.06.020
  177. Nishida KM, Sakakibara K, Sumiyoshi T, Yamazaki H, Mannen T, Kawamura T, Kodama T, Siomi MC.
    Siwi levels reversibly regulate secondary piRISC biogenesis by affecting Ago3 body morphology in Bombyx mori.
    EMBO J. 39:2020, e105130. DOI:10.15252/embj.2020105130
  178. Uchigashima M, Konno K, Demchak E, Cheung A, Watanabe T, Keener D G, Abe M, Sakimura K, Sasaoka T, Uemura T, Imamura Karasawa Y, Watanabe M, Futai K.
    Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus.
    Elife 9:2020, e59545. DOI:10.7554/eLife.59545
  179. Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H.
    Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells.
    Biomed Pharmacother. 128:2020, 110330-110340. DOI:10.1016/j.biopha.2020.110330
  180. Suzuki S, Minamidate T, Shiga A, Ruike Y, Ishiwata K, Naito K, Ishida A, Deguchi H, Fujimoto M, Koide H, Tatsuno I, Ikeda JI, Yamazaki Y, Sasano H, Yokote K.
    Steroid metabolites for diagnosing and predicting clinicopathological features in cortisol-producing adrenocortical carcinoma.
    BMC Endocr Disord. 20:2020, in press. DOI:10.1186/s12902-020-00652-y
  181. Moe Matsushita, Takanori Nakamura, Hisashi Moriizumi, Hiroaki Miki, Mutsuhiro Takekawa
    Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress.
    Science Advances 6(26):2020, eaay9778. DOI:10.1126/sciadv.aay9778
  182. Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, and Noriyuki Sugo
    Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons.
    The Journal of Neuroscience 40(47):2020, 9012-9027. DOI:10.1523/JNEUROSCI.0319-20.2020
  183. Lin, Z, Nishikawa, H, Iguchi, Y, Iwanami, A, Kikuchi, M, Toda, S
    Sustaining temporal attention prevents habit expression during operant learning in rats.
    Scientific Reports 10(1):2020, 10303. DOI:10.1038/s41598-020-67304-y
  184. Takumi Kobayashi, Ryo, C. Yanagita, Kazuhiro Irie
    Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/pi interaction.
    Bioorganic & Medicinal Chemistry Letters 30:2020, 127657. DOI:10.1016/j.bmcl.2020.127657
  185. Yasuda M, Ma Y, Okabe S, Wakabayashi Y, Su D, Chang YT, Seimiya H, Tera M, Nagasawa K.
    Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization.
    Chem Commun 56:2020, 12905-12908. DOI:10.1039/d0cc04957c
  186. Yamamoto, M., Ichinohe, T., Watanabe, A., Kobayashi, A., Zhang, R., Song, J., Kawaguchi, Y., Matsuda, Z. and Inoue, J.
    The antimalarial compound atovaquone inhibits Zika and dengue virus infection by blocking E protein-mediated membrane fusion.
    Viruses 12:2020, 1475. DOI:10.3390/v1212475
  187. Tadashi Nakagawa, Satoko Hattori, Tsuyoshi Miyakawa, Keiko Nakayama
    The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression.
    iScience 23(4):2020, 101030. DOI:10.1016/j.isci.2020.101030
  188. Mugat B, Nicot S, Chavez CV, Jourdan C, Sato K, Basyuk E, Juge F, Siomi MC, Pelisson A, Chambeyron S.
    The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation.
    Nature Com. 11:2020, 2828. DOI:10.1038/s41467-020-16635-5
  189. Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, Yoshida K.
    The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
    eLife 9:2020, e57381. DOI:10.7554/eLife.57381
  190. Higashi H, Kato Y, Fujita T, Iwasaki S, Nakamura M, Nishimura Y, Takenaka M, and Shikanai T.
    The pentatricopeptide repeat protein PGR3 is required for the translation of petL and ndhG by binding their 5'UTRs.
    Plant Cell Physiol. in press:2020, in press. DOI:10.1093/pcp/pcaa180
  191. Okumura K, Wakabayashi Y
    The role of calcium metabolism in keratinocyte differentiation.
    Trends in Cancer Research 14:2020, 45-47.
  192. Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Tokunaga F, Tsukagoshi H, Ishikawa O.
    The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis.
    J Am Acad Dermatol. -:2020, in press. DOI:10.1016/j.jaad.2020.05.051
  193. Tetsuhisa Otani, Mikio Furuse
    Tight Junction Structure and Function Revisited.
    Trends in Cell Biology 30(10):2020, 805-817. DOI:10.1016/j.tcb.2020.08.004
  194. Nakagawa S, Nguyen Pham KT, Shao X, and Doi M
    Time-restricted G-protein signaling pathways via GPR176, Gz, and RGS16 set the pace of the master circadian clock in the suprachiasmatic nucleus.
    Int J Mol Sci 21:2020, 5055. DOI:10.3390/ijms21145055
  195. Kurihara Y., Makita Y., Shimohira H., Fujita T., Iwasaki S., and Matsui M.
    Translational landscape of protein-coding and non-protein-coding RNAs upon light exposure in Arabidopsis.
    Plant Cell Physiol. 61(3):2020, 536-545 . DOI:10.1093/pcp/pcz219
  196. Naoto Hori, Kazuyuki Okada, Yuki Takakura, Hiroyuki Takano, Naoto Yamaguchi, Noritaka Yamaguchi
    Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway.
    Journal of Biological Chemistry 295:2020, 8798-8807. DOI:10.1074/jbc.RA120.012781
  197. Kuboyama K, Shirakawa Y, Kawada K, Fujii N, Ojima D, Kishimoto Y, Yamamoto T, Yamada MK
    Visually cued fear conditioning test for memory impairment related to cortical function.
    Neuropsychopharmacol. Rep. 40:2020, 371-375. DOI:10.1002/npr2.12146
  198. 森 拓也, 川原 勲, 額賀翔太,宮川良博, 後藤 桂, 大森 斉, 國安弘基
    がん性サルコペニアに対する栄養介入.
    奈良医学雑誌 71(1-3):2020, 1-5.
  199. 八尾寛,深沢有吾,冨田浩史,五十嵐敬幸
    ラットを用いたオプトジェネティクス(光遺伝学).
    LABIO21 80:2020, 5-8.
  200. Nguyen Pham Khanh Tien、土居雅夫
    時計遺伝子の転写のシス制御エレメントに点変異を入れると体内時計はどうなるのか.
    Journal of Japanese Biochemical Society 92(5):2020, 735-739. DOI:10.14952/SEIKAGAKU.2020.920735

2019年度

  1. Kataoka, N., Shima, Y., Nakajima, K., Nakamura, K.
    A central master driver of psychosocial stress responses in the rat.
    Science 367:2020, 1105-1112. DOI:10.1126/science.aaz4639
  2. Hamm JP, Shymkiv Y, Mukai J, Gogos JA, Yuste R.
    Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a+/- Mice.
    Biological Psychiatry in Press:2020, in Press. DOI:10.1016/j.biopsych.2020.01.004
  3. Wada S, Yanagida J, Sasase H, Zhang T, Li X, Kamii H, Domoto M, Deyama S, Hinoi E, Yamanaka A, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K
    Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice.
    Neuropharmacology 166:2020, 107968. DOI:10.1016/j.neuropharm.2020.107968
  4. Ninagawa J, Sumitani M, Nishizawa D, Nagashima M, Mietani K, Abe H, Inoue R, Hozumi J, Tsuchida R, Ikeda K, Yamada Y
    Adiponectin receptor 1 gene is potentially associated with severity of postoperative pain but not cancer pain.
    Medicine (Baltimore) 99(5):2020, e18924. DOI:10.1097/MD.0000000000018924
  5. Matsushima S, Shimizu A, Kondo M, Asano H, Ueno N, Nakayama H, Sato N, Komeno M, Ogita H, Kurokawa-Seo M.
    Anosmin-1 activates vascular endothelial growth factor receptor and its related signaling pathway for olfactory bulb angiogenesis.
    Sci Rep 10:2020, 188. DOI:10.1038/s41598-019-57040-3
  6. Kataura T, Saiki S, Ishikawa K, Akamatsu W, Sasazawa Y, Hattori N, Imoto M
    BRUP-1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson's disease model.
    J. Neurochemstry :2020, in press. DOI:10.1111/jnc.14997
  7. R Ohashi and N Shiina
    Cataloguing and selection of mRNAs localized to dendrites in neurons and regulated by RNA-binding proteins in RNA granules.
    Biomolecules 10:2020, 167. DOI:10.3390/biom10020167
  8. Takeda K, Miyamoto Y, Yamamoto H, Ishii A, Hirose S, Yamamoto H.
    Clinical features of early myoclonic encephalopathy caused by a CDKL5 mutation.
    Brain Dev. 42(1):2020, 73-76. DOI:10.1016/j.braindev.2019.08.003
  9. Nakahata S , et al, Saito M, Morishita K.
    Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma.
    Haematologica :2020, in Press. DOI:10.3324/haematol.2019.234096
  10. Kana Aoki, Shinsuke Satoi, Shota Harada, Seiichi Uchida, Yoh Iwasa, Junichi Ikenouchi
    Coordinated Changes in Cell Membrane and Cytoplasm During Maturation of Apoptotic Bleb.
    Mol Biol Cell :2020, in press. DOI:10.1091/mbc.E19-12-0691
  11. Yamaguchi S, Oe A, Nishida KM, Yamashita K, Kajiya A, Hirano S, Matsumoto N, Dohmae N, Ishitani R, Saito K, Siomi H, Nishimasu H, Siomi MC, Nureki O.
    Crystal structure of Drosophila Piwi.
    Nature Communications 11(1):2020, 858. DOI:10.1038/s41467-020-14687-1
  12. Takeshita N, Kawade N, Suzuki W, Hara S, Horio F, Ichinose H
    Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats.
    Neurosci Lett 715:2020, 134656. DOI:10.1016/j.neulet.2019.134656
  13. Nakata S, Takemoto M, Song W-J.
    Differential cortical and subcortical projection targets of subfields in the core region of mouse auditory cortex.
    Hearing Research 386:2020, 107876. DOI:10.1016/j.heares.2019.107876
  14. Han Y, Nakayama J, Hayashi Y, Jeong S, Futakuchi M, Ito E, Watanabe S and Semba K
    Establishment and characterization of highly osteolytic luminal breast cancer cell lines by intra-caudal arterial injection.
    Genes to Cells 25:2020, 111-123. DOI:10.1111/gtc.12743
  15. Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Furukawa T & Shoji Natsugoe et al.
    FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer.
    Oncogenesis 9:2020, 13. DOI:10.1038/s41389-020-0190-7
  16. Yoo SM, Yamashita SI, Kim H, Na D, Lee H, Kim SJ, Cho DH, Kanki T, Jung YK.
    FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.
    FASEB J. 34(2):2020, 2944-2957. DOI:10.1096/fj.201901735R
  17. Higa N, Shinsato Y, Kamil M, Hirano T, Takajo T, Shimokawa M, Minami K, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K and Arita K
    Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis.
    Int J Mol Sci 20:2020, 6355. DOI:10.3390/ijms20246355
  18. Igarashi R, Yamashita SI, Yamashita T, Inoue K, Fukuda T, Fukuchi T, Kanki T.
    Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1.
    Sci Rep. 10(1):2020, 1465. DOI:10.1038/s41598-020-58315-w
  19. Shiori Suzuki#, Shuichi Tsutsumi#, Yu Chen#, Chikako Ozeki, Atsushi Okabe, Tatsuya Kawase, Hiroyuki Aburatani and Rieko Ohki*.
    Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain.
    Cancer Science 111:2020, 451-466. DOI:10.1111/cas.14279
  20. Wang T, Nakagawa S, Miyake T, Setsu G, Kunisue S, Goto K, Hirasawa A, Okamura H, Yamaguchi Y, and Doi M
    Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176.
    Sci. Rep. 10:2020, 4429. DOI:10.1038/s41598-020-61370-y
  21. Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.
    Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA.
    Cell Chemical Biology 27:2020, 186-196.e4. DOI:10.1016/j.chembiol.2019.11.010
  22. Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, .., Ogita H.
    Identification of Transmembrane Protein 168 Mutation in Familial Brugada Syndrome.
    FASEB J 34(5):2020, 6399-6417. DOI:10.1096/fj.201902991R
  23. Kato S., Shirai Y., Motozono, C., Kanzaki, H., Mori, S., Kodama, T.
    In vivo delivery of an exogenous molecule into murine T lymphocytes using a lymphatic drug delivery system combined with sonoporation.
    Biochem Biophys Res Commun. 525(4):2020, 1025-1031. DOI:10.1016/j.bbrc.2020.02.174
  24. Kawahata T, Kawahara K, Shimokawa M, Sakiyama A, Shiraishi T, Minami K, Yamamoto M, Shinsato Y, Arima K, Hamada T, Furukawa T
    Involvement of ribosomal protein L11 expression in sensitivity of gastric cancer against 5-FU.
    ONCOLOGY LETTERS 19:2020, 2258-2264. DOI:10.3892/ol.2020.11352
  25. Wei R, Sugiyama A, Sato Y, Nozumi M, Nishino H, Takahashi M, Saito T, Ando K, Fukuda M, Tomomura M, Igarashi M, *Hisanaga S-i
    Isoform-dependent subcellular localization of LMTK1A and LMTK1B, and their roles in axon outgrowth and spine formation.
    J Biochem :2020, in press. DOI:10.1093/jb/mvaa019
  26. Tsutomu Fukuda, Fumito Ishibashi, Masatomo Iwao
    Lamellarin alkaloids: Isolation, synthesis, and biological activity.
    The Alkaloids: Chemistry and Biology 83:2020, 1-112. DOI:10.1016/bs.alkal.2019.10.001
  27. Tetsuya Sasaki, Yosuke Takei
    Localization Mechanism of Myosin Id, an ASD Risk Gene Product in Dendritic Spines.
    Jap J Biological Psych. 31(2):2020, in press.
  28. Hossain MR, Jamal M, Tanoue Y, Ojima D, Takahashi H, Kubota T, Ansary TM, Ito A, Tanaka N, Kinoshita H, Kishimoto Y, Yamamoto T
    MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism: An ex vivo HPLC-ECD analysis.
    Neurosci. Lett. 716:2020, 134677. DOI:10.1016/j.neulet.2019.134677
  29. Ishiguro K (Corresponding), Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, Sugimoto M, Fujimura S, Hosokawa M, Chuma S, Ko S.H.M, Araki K, Niwa H
    MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells.
    Developmental Cell 52(4):2020, 429-445. DOI:10.1016/j.devcel.2020.01.010
  30. Sugimoto Y., Naniwa K., Aonuma H. and Osuka K.
    Microinjection support system for small biological subject.
    HardwareX :2020, e00103. DOI:10.1016/j.ohx.2020.e00103
  31. R Roy, N Shiina, and D O Wang
    More dynamic, more quantitative, unexpectedly intricate: Advanced understanding on synaptic RNA localization in learning and memory.
    Neurobiology of Learning and Memory 168:2020, 107149 - 107149. DOI:10.1016/j.nlm.2019.107149
  32. 武山祐士、加藤実、清水保臣、東由香里、玉田聡、井口太郎、山崎健史、魏民、鰐渕英機、仲谷達也
    Myeloid-derived suppressor cells are essential partners for immune checkpoint inhibitors in the treatment of cisplatin-resistant bladder cancer.
    Cancer Letters :2020, in press. DOI:10.1016/j.canlet.2020.03.013
  33. Sanchez-Martin P, Sou YS, Kageyama S, Koike M, Waguri S, *Komatsu M.
    NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.
    EMBO Rep. 21:2020, e48902. DOI:10.15252/embr.201948902
  34. Matsumura K, Nakazawa T, et al.
    Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.
    Nat Commun 11:2020, 859. DOI:10.1038/s41467-020-14697-z
  35. Kawashima M, Carreras J, Higuchi H, et al
    PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma.
    Leukemia. :2020, in press. DOI:10.1038/s41375-020-0737-9
  36. Nakano Y, Hirooka K, Chiba Y, Ueno M, Ojima D, Hossain MR, Takahashi H, Yamamoto T, Kiuchi Y
    Retinal ganglion cell loss in 1 kinesin-1 cargo Alcadein α deficient mice.
    Cell Death Dis. 11(3):2020, 166. DOI:10.1038/s41419-020-2363-x
  37. Nishiguchi Y, Oue N, Fujiwara-Tani R, Sasaki T, Ohmori H, Kishi S, Shiori Mori S, Mori T, Ideda N, Matsumoto S, Wakatsuki K, Luo Y, Yasui W, Sho M, Kuniyasu H
    Role of metastasis-related genes in cisplatin chemoresistance in gastric cancer.
    Int J Mol Sci 21:2020, 254. DOI:10.3390/ijms21010254
  38. Yohei Yamagami, Masashi Kawami, Takamichi Ojima, Sora Futatsugi, Ryoko Yumoto, Mikihisa Takano
    Role of plasminogen activator inhibitor-1 in methotrexate-induced epithelial-mesenchymal transition in alveolar epithelial A549 cells.
    Biochem Biophys Res Commun 525(3):2020, 543-548. DOI:10.1016/j.bbrc.2020.02.131
  39. Wakita M, Yamagata A, Shiroshima T, Izumi H, Maeda A, Sendo M, Imai A, Kubota K, Goto-Ito S, Sato Y, Mori H, Yoshida T, Fukai S.
    Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α.
    Nature Communications 11:2020, 649. DOI:10.1038/s41467-020-14516-5
  40. (2) Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunag F, Sawasaki T.
    Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling.
    Biochem Biophys Res Commun. 524(1):2020, 1-7. DOI:10.1016/j.bbrc.2019.12.049
  41. 横山 玲、樋口 桃子、田邊 航、塚田 信司、内藤 恵、Lu Chen、笠井 淳司、勢力 薫、中澤 敬信、中川 晋作、橋本 謙二、橋本 均、吾郷 由希夫
    (S)-norketamine and (2S,6S)-hydroxynorketamine Exert Potent Antidepressant-Like Effects in a Chronic Corticosterone-Induced Mouse Model of Depression.
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    Proceedings of the National Academy of Sciences of the United States of America 116 (52):2019, 26313-26320. DOI:10.1073/pnas.1902283116
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    Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation.
    Circulation 139:2019, 2157-2169. DOI:10.1161/CIRCULATIONAHA.118.036761
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    Newborn screening for Pompe disease in Japan: report and literature review of mutations in the GAA gene in Japanese and Asian patients.
    J Hum Genet. 64(8):2019, 741-755. DOI:10.1038/s10038-019-0603-7
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    Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity.
    Nature Commun. 10:2019, 2563. DOI:10.1038/s41467-019-10532-2
  129. Shotaro Yamano, Makoto Kimura, Yu Chen, Naoko Imamoto* and Rieko Ohki*.
    Nuclear import of IER5 is mediated by a classical bipartite nuclear localization signal and is required for HSF1 full activation.
    Experimental Cell Research 386(1):2019, 111686. DOI:10.1016/j.yexcr.2019.111686
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    Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing.
    EMBO J 38(17):2019, e102870. DOI:10.15252/embj.2019102870
  131. Ghandour K, Ohkawa N, Chung C, Fung A, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, Nishizono H, Matsuo M, Osanai M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Kitamura T, Fukai T, Inokuchi K
    Orchestrated ensemble activities constitute a hippocampal memory engram.
    Nature Communications 10:2019, 2637. DOI:10.1038/s41467-019-10683-2
  132. Fujii T, Chiba Y, Nakayama-Imaohji H, Onishi S, Tanaka A, Katami H, Kaji T, Ieiri S, Miki T, Ueno M, Kuwahara T, Shimono R
    Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.
    J Pediatr Surg 54(12):2019, 2514-2519. DOI:10.1016/j.jpedsurg.2019.08.048
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    Phosphorylation sites of microtubule-associated protein 1B (MAP1B) involved in axon growth and regeneration.
    Mol Brain 12:2019, 93. DOI:10.1186/s13041-019-0510-z
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    Physiological Stress Response by Selective Autophagy.
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    Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation.
    Journal of Neuroscience 39 (22):2019, 4208-4220. DOI:10.1523/JNEUROSCI.2468-18.2019
  136. Watanabe T, Suzuki H, Kano M
    Postnatal Development of Cerebellar Neural Circuits.
    Brain Nerve. 12:2019, 1373-1383. DOI:10.11477/mf.1416201457
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    Prefrontal-Enriched SLIT1 Expression in Primate Cortex and its Alteration during Cortical Development.
    Jap J Biological Psych. 30(2).:2019, 81-85. DOI:10.11249/jsbpjjpp.30.2_81
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    PRRT2 mutations in Japanese patients with benign infantile epilepsy and paroxysmal kinesigenic dyskinesia.
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    Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.
    Neuropsychopharmacology 44:2019, 2125-2135. DOI:10.1038/s41386-019-0441-5
  140. Inoue M, Takeuchi A, Manita S, Horigane SI, Sakamoto M, .. , Bito H.
    Rational engineering of XCaMPs, a multicolor GECI suite for in vivo imaging of complex brain circuit dynamics.
    Cell 177:2019, 1346-1360. DOI:10.1016/j.cell.2019.04.007
  141. Mukai J, Cannavo E, Crabtree GW, Sun Z, Diamantopoulou A, Thakur P, Chang CY, Cai Y, Lomvardas S, Takata A, Xu B, Gogos JA.
    Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice.
    Neuron 104:2019, 471-487. DOI:10.1016/j.neuron.2019.09.014
  142. Miyake T, and Doi M
    Reconstitution of Organismal Liver Clock Function Requires Light.
    Trends Endocrinol Metab. 30:2019, 569-571. DOI:10.1016/j.tem.2019.07.017
  143. Isokawa M, Sassa T, Hattori S, Miyakawa T, Kihara A
    Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1.
    FASEB BioAdvances 1:2019, 747-759. DOI:10.1096/fba.2019-00067
  144. Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, Ohmura Y, Mizoguchi H, Kimura K, Yoshioka M, Terao A, Kilduff TS, Yamanaka A*
    REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories. .
    Science 365(6459):2019, 1308-1313. DOI:10.1126/science.aax9238
  145. Yoshiyuki Kasahara Yasufumi Sakakibara Takashi Hiratsuka Yuki Moriya Klaus‐Peter Lesch F. Scott Hall George R. Uhl Ichiro Sora
    Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice.
    Neuropsychopharmacol Rep 39(2):2019, 130-133. DOI:10.1002/npr2.12049.
  146. Hirakata S, Ishizu H, Fujita A, Tomoe Y, Siomi MC.
    Requirements for multivalent Yb body assembly in transposon silencing in Drosophila.
    EMBO Rep. 20(7):2019, e47708. DOI:10.15252/embr.201947708
  147. Maho Tsubota, ..Shuji Wakatsuki,.., Atsufumi Kawabata
    Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants.
    J Neuroinflamm 16:2019, 199. DOI:10.1186/s12974-019-1581-6
  148. Nie X, Kitaoka S, Shinohara M, Kakizuka A, Narumiya S, Furuyashiki T.
    Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance.
    Sci Rep 9:2019, 17548. DOI:10.1038/s41598-019-54082-5
  149. Kensuke Yamamoto, Yusei Mohara, Yuichiro Mutoh, and Shinichi Saito
    Ruthenium-Catalyzed (Z)-Selective Hydroboration of Terminal Alkynes with Naphthalene-1,8-diaminatoborane.
    J AM CHEM SOC 141:2019, 17042-17047. DOI:10.1021/jacs.9b06910
  150. Tomomi Sanagi, Tetsuya Sasaki, Takafumi Minamimoto, Shin-ichi Kohsaka, and Noritaka Ichinohe
    Segmented Iba1-positive processes of microglia in autism model marmosets.
    Front Cell Neurosci, section Cellular Neuropathology 13:2019, 344-350. DOI:10.3389/fncel.2019.00344
  151. Toshio Fujino and Tetsuya Mitsudomi
    Sensitivity and Resistance of MET Exon 14 Mutations in Lung Cancer to Eight MET Tyrosine Kinase Inhibitors In Vitro.
    Journal of thoracic oncology 14:2019, 1753, 1765. DOI:10.1016/j.jtho.2019.06.023
  152. Sobuz SU, Sato Y, Yoshizawa T, Karim MF, Ono K, Sawa T, Miyamoto Y, Oka Y, Yamagata K
    SIRT7 regulates the nuclear export of NF-kB p65 by deacetylating Ran.
    BBA - Mol Cell Res 1866:2019, 1355-1367. DOI:10.1016/j.bbamcr.2019.05.001
  153. Numa C, Nagai H, Taniguchi M, Nagai M, Shinohara R, Furuyashiki T.
    Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex.
    Sci Rep 9:2019, 16670. DOI:10.1038/s41598-019-52997-7
  154. Kikuta S, Iguchi Y, Kakizaki T, Kobayashi K, Yanagawa Y, Takada M, Osanai M
    Store-operated calcium channels are involved in spontaneous slow calcium oscillations in striatal neurons.
    Frontiers in Cellular Neuroscience 13:2019, 547. DOI:10.3389/fncel.2019.00547
  155. Shinohara, F., Asaoka, Y., Kamii, H., Minami, M., Kaneda, K.
    Stress augments the rewarding memory of cocaine via the activation of brainstem-reward circuitry.
    Addiction Biology 24:2019, 509-521. DOI:10.1111/adb.12617
  156. Yuichiro Mutoh, Kensuke Yamamoto, Shinichi Saito
    Suzuki-Miyaura Cross-Coupling of 1,8-Diaminonaphthalene (dan)-Protected Arylboronic Acids.
    ACS CATAL 10:2019, 352-357. DOI:10.1021/acscatal.9b03667
  157. Chi-Wai Fung, Go Fukada, Yuichiro Mutoh, Noriko Tsuchida, Shinchi Saito
    Synthesis and properties of anionic ruthenium thionitrosyl and selenonitrosyl complexes that contain tetraanionic 2-hydroxybenzamidobenzene ligands.
    DALTON TRANSACTIONS 49:2019, 613-624. DOI:10.1039/C9DT04219A
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    Synthesis of Helical 3,3′-Bridged-2,2′-bibenzo[g]quinolines.
    CHEMISTRY LETTERS 49:2019, 133-136. DOI:10.1246/cl.190803
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    Synthesis of lactone-fused pyrroles by ruthenium-catalyzed 1,2-carbon migration-cycloisomerization.
    ORG BIOMOL CHEM 18:2019, 81-85. DOI:10.1039/C9OB02363A
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    Targeting claudin-4 enhances CDDP-chemosensitivity of gastric cancer.
    Oncotarget 10:2019, 2189-2202. DOI:10.18632/oncotarget.26758
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    Targeting claudin-4 enhances chemosensitivity of pancreatic ductal carcinomas.
    Cancer Med 8:2019, 6700-6708. DOI:10.1002/cam4.2547
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    The effect of MR1 ligand glycol-analogues on mucosal-associated invariant T (MAIT) cell activation.
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    Cancer Res 80:2019, 471-483. DOI:10.1158/0008-5472.CAN-19-1196
  164. Ahmat Amin MKB, Shimizu A, Ogita H.
    The pivotal roles of the epithelial membrane protein family in cancer invasiveness and metastasis.
    Cancers 11:2019, E1620. DOI:10.3390/cancers11111620
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    Three-dimensional fluorescence imaging using the transport of intensity equation.
    J Biomed Opt 25:2019, 1-7. DOI:10.1117/1.JBO.25.3.032004
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    Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter.
    Gynecol Oncology 155(2):2019, 31478-31487. DOI:10.1016/j.ygyno.2019.08.026
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    Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy. .
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    Visualization of brain activity in a neuropathic pain model using quantitative activity-dependent manganese magnetic resonance imaging.
    Frontiers in Neural Circuits 13:2019, 74. DOI:10.3389/fncir.2019.00074
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    Whole-brain Block-Face Serial Microscopy Tomography at Subcellular Resolution Using FAST.
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    Zn(OTf)2-mediated annulations of N-propargylated tetrahydrocarbolines: divergent synthesis of four distinct alkaloidal scaffolds.
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    骨転移とマイクロRNA.
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    定量的マンガン造影MRI を用いた疾患モデル動物の神経活動計測.
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2018年度

  1. Hiroaki Tagaya, Kosuke Ishikawa, Yoshito Hosokawa, Shun Kobayashi, Yukino Ueoka, Mayuna Shimada, Yasuko Ohashi, Hirofumi Mikami, Mizuki Yamamoto, Tatsuya Ihara, Kentaro Kumazawa, Kosuke Sugihara, Naoki Goshima, Shinya Watanabe and Kentaro Semba
    A method of producing genetically manipulated mouse mammary gland.
    Breast Cancer Research 21:1, 2019. DOI:10.1186/s13058-018-1086-8
  2. Saito M, Okumura K, Isogai E, Araki K, Tanikawa C, Matsuda K, Kamijo T, Kominami R, Wakabayashi Y.
    A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway.
    Journal of Investigative Dermatology 139(7):1459-1469, 2019. DOI:10.1016/j.jid.2018.12.027
  3. Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Tani H, Mito T, Matsumoto H, Miyakawa T, Nakada K.
    Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior.
    Journal of Neuroscience 39(9):1588-1604, 2019. DOI:10.1523/JNEUROSCI.2139-18.2018
  4. Kurosaki H, Yamaguchi K, Man-Yoshi K, Muramatsu SI, Hara S, Ichinose H
    Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP.
    Neurochemistry International 125:16-24, 2019. DOI:10.1016/j.neuint.2019.02.005
  5. Saitoh, S. I., Y. M. Saitoh, K. Kontani, K. Sato, and K. Miyake.
    ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus.
    Int Immunol. :in press, 2019. DOI:10.1093/intimm/dxy084
  6. Egawa R, Yawo H.
    Analysis of Neuro-Neuronal Synapses Using Embryonic Chick Ciliary Ganglion via Single-Axon Tracing, Electrophysiology, and Optogenetic Techniques.
    Curr Protoc Neurosci. :e64, 2019. DOI:10.1002/cpns.64
  7. Ikeda K, Kaneko R Yanagawa Y, Ogawa M,et al.
    Analysis of the neuronal network of the medullary respiratory center in transgenic rats expressing archaerhodopsin-3 in Phox2b-expressing cells.
    Brain Res Bull 144:39-45, 2019. DOI:10.1016/j.brainresbull.2018.11.005
  8. Nam SA, Kim WY, Kim JW, Park SH, Kim HL, Lee MS, Komatsu M, Ha H, Lim JH, Park CW, Yang CW, Kim J, Kim YK.
    Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway.
    Cell Death Dis. 10(2):535-540, 2019. DOI:10.1038/s41419-019-1356-0
  9. Saito T., Komatsu M. (19人中19番目)
    Autophagy regulates lipid metabolism through selective turnover of NCoR1.
    Nat.Commun. 10:1567, 2019. DOI:10.1038/s41467-019-08829-3
  10. Hashimoto K, Sato S, Ochi H, Takeda S, Futakuchi M
    Calvarial Bone Implantation and in vivo Imaging of Tumor Cells in Mice.
    Bio Protoc 9(3):e3151, 2019. DOI:10.21769/BioProtoc.3151
  11. Akichika S., Hirano S., Shichino Y., Suzuki T., Nishimasu H., Ishitani R., Sugita A., Hirose Y., Iwasaki S., Nureki O., and Suzuki T.
    Cap-specific terminal N6-methylation of RNA by an RNA polymerase II-associated methyltransferase Cap.
    Science 11(363):6423, 2019. DOI:10.1126/science.aav0080
  12. Saitoh F, Hagiwara H, Wakatsuki S, Araki T.
    Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency.
    Neuroscience Resarch 139:58-62, 2019. DOI:10.1016/j.neures.2018.08.015
  13. Ohta K, Aoyama E, Ahmad SAI, Ito N, Anam MB, Kubota S, Takigawa M.
    CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.
    J Cell Commun Signal. 13(1):113-118, 2019. DOI:10.1007/s12079-018-0487-x
  14. Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M.
    Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.
    Nautre communications 10 (1):981, 2019. DOI:10.1038/s41467-019-08957-w
  15. Harada, T., Matsumoto, S., Hirota, S., Kimura, H., Fujii, S., Kasahara, Y., Gon, H., Yoshida, T., Itoh, T., Haraguchi, N., Mizushima, T., Noda, T., Eguchi, H., Nojima, S., Morii, E., Fukumoto, T., Obika, S., Kikuchi, A.
    Chemically modified antisense oligonucleotide against ARL4C inhibits primary and metastatic liver tumor growth.
    Mol. Cancer Ther. 18:602-612, 2019. DOI:10.1158/1535-7163.MCT-18-082
  16. Orimo, T., I. Sasaki, H. Hemmi, T. Ozasa, Y. Fukuda-Ohta, T. Ohta, M. Morinaka, M. Kitauchi, T. Yamaguchi, Y. Sato, T. Tanaka, K. Hoshino, K. I. Katayama, S. Fukuda, K. Miyake, M. Yamamoto, T. Satoh, K. Furukawa, E. Kuroda, K. J. Ishii, K. Takeda, and T. Kaisho.
    Cholera toxin B induces interleukine-1β production from resident peritoneal macrophages through pyrin as well as NLRP3 inflammasome.
    Int Immunol. :in press, 2019. DOI:10.1093/intimm/dxz004
  17. Adhikara IM, *Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata K, Emoto N
    Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.
    Biochem Biophys res Commun 509:89-95, 2019. DOI:10.1016/j.bbrc.2018.12.068
  18. Kimura H, Yamamoto H, Harada T, Fumoto K, Osugi Y, Sada R, Maehara N, Hikita H, Mori S, Eguchi H, Ikawa M, Takehara T, Kikuchi A.
    CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy.
    Clin Cancer Res. 25:1936-1947, 2019. DOI:10.1158/1078-0432.CCR-18-2124
  19. Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.
    CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.
    Oncogene 14:2580-2594, 2019. DOI:10.1038/s41388-018-0603-7
  20. Bando Y*, Sakamoto M* (Co-first and corresponding author), Kim S, Ayzenshtat I, Yuste R.
    Comparative evaluation of genetically encoded voltage indicators.
    Cell Reports 26(3):802-813, 2019. DOI:10.1016/j.celrep.2018.12.088
  21. Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
    Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy.
    Pathobiology 86:182-189, 2019. DOI:10.1159/000496027
  22. Furusho, K., T. Shibata, R. Sato, R. Fukui, Y. Motoi, Y. Zhang, S. I. Saitoh, T. Ichinohe, M. Moriyama, S. Nakamura, and K. Miyake.
    Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.
    Int Immunol. 31:167-173, 2019. DOI:10.1093/intimm/dxy075
  23. Naniwa K., Sugimoto Y., Osuka K. and Aonuma H.
    Defecation initiates walking in the cricket Gryllus bimaculatus.
    J. Insect Physiol. 112:117-122, 2019. DOI:10.1016/j.jinsphys.2018.11.004
  24. Sashida G, Oshima M, Iwama A.
    Deregulated Polycomb functions in myeloproliferative neoplasms.
    Int J Hematol 110(2):170-178, 2019. DOI:10.1007/s12185-019-02600-6
  25. Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
    Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.
    Oncogene 38:635-655, 2019. DOI:10.1038/s41388-018-0481-z
  26. Serita, T., Miyahara, M., Tanimizu, T., Takahashi, S., Oishi, S., Nagayoshi, T., Tsuji, R., Inoue, H., Uehara, M., Kida, S*.
    Dietary magnesium deficiency impairs hippocampus-dependent memories without changes in the spine density and morphology of hippocampal neurons in mice.
    Brain Res Bull. 144:149-157, 2019. DOI:10.1016/j.brainresbull.2018.11.019
  27. Yoshitomi S, Takahashi Y, Imai K, Koshimizu E, Miyatake S, Nakashima M, Saitsu H, Matsumoto N, Kato M, Fujita T, Ishii A, Hirose S, Inoue Y.
    Different types of suppression-burst patterns in patients with epilepsy of infancy with migrating focal seizures (EIMFS).
    Seizure 65:118-123, 2019. DOI:10.1016/j.seizure.2019.01.009
  28. Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Mizutani A, et al.
    Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
    Journal of Medicinal Chemistry 62(7):3407-3427, 2019. DOI:10.1021/acs.jmedchem.8b01888
  29. Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI.
    Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
    J. Exp. Med. 216:950-965, 2019. DOI:10.1084/jem.20180900
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    Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer.
    Exp Ther Med 16(6):4463-4470, 2018. DOI:10.3892/etm.2018.6787
  253. Zhang, Z., U. Ohto, T. Shibata, M. Taoka, Y. Yamauchi, R. Sato, N. M. Shukla, S. A. David, T. Isobe, K. Miyake, and T. Shimizu.
    Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
    Cell Rep 25(12):3371-3381, 2018. DOI:10.1016/j.celrep.2018.11.081
  254. Ishida, H., U. Ohto, T. Shibata, K. Miyake, and T. Shimizu.
    Structural basis for species-specific activation of mouse Toll-like receptor 9.
    FEBS Lett 592(15):2636-2646, 2018. DOI:10.1002/1873-3468.13176
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    Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
    Nat Commun. 9:4424, 2018. DOI:10.1038/s41467-018-06922-7
  256. Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ.
    Study on the tumor-induced angiogenesis using mathematical models.
    Cancer Science 109:15-23, 2018. DOI:10.1111/cas.13395
  257. Akatsuka S, Li GH, Toyokuni S
    Superiority of rat over murine model for studies on the evolution of cancer genome.
    Free Radical Research 52:1323-1327, 2018. DOI:10.1080/10715762.2018.1467562
  258. Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
    Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output.
    Cell Rep. 25:2704-2715, 2018. DOI:10.1016/j.celrep.2018.11.016
  259. Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S. and Irie, K.
    Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin.
    Heterocycles 97(1):478-492, 2018. DOI:10.3987/COM-18-S(T)37
  260. Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
    Systematic review of pre-clinical chronic myeloid leukaemia.
    Int J Hematol. 108(5):465-484, 2018. DOI:10.1007/s12185-018-2528-x
  261. Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H
    Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
    Sci Rep. 8(1):5435, 2018. DOI:10.1038/s41598-018-23810-8
  262. de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu To, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R
    Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds.
    EMBO Mol Med 10(10):e9024, 2018. DOI:10.15252/emmm.201809024
  263. Okada K, Nishizawa K, Setogawa S, Hashimoto K, Kobayashi K.
    Task-dependent function of striatal cholinergic interneurons.
    Eur J Neurosci 47(10):1174-1183., 2018. DOI:10.1111/ejn.13768
  264. Kita Y., Katayama Y., Shiraishi T., Oka T., Sato T., Suyama M., Ohkawa Y., Miyata K., Oike Y., Shirane M., Nishiyama M., Nakayama KI.
    The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.
    Cell Rep. 23:1988-2000, 2018. DOI:10.1016/j.celrep.2018.04.050
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    The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.
    Cell Struct. Funct. 43:75-83, 2018. DOI:10.1247/csf.18005
  266. Pelka, K., D. Bertheloot, E. Reimer, K. Phulphagar, S. V. Schmidt, A. Christ, R. Stahl, N. Watson, K. Miyake, N. Hacohen, A. Haas, M. M. Brinkmann, A. Marshak-Rothstein, F. Meissner, and E. Latz.
    The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.?.
    Immunity 48(5):911-922, 2018. DOI:10.1016/j.immuni.2018.04.011
  267. Lorente J, Velandia C, Leal JA, Garcia-Mayea Y, Lyakhovich A, Kondoh H, LLeonart ME.
    The interplay between autophagy and tumorigenesis: exploiting autophagy as a means of anticancer therapy.
    Biol Rev Camb Philos Soc. 93, 1:P152?165, 2018. DOI:10.1111/brv.12337
  268. Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H, Kirita T.
    The multifarious functions of pyruvate kinase M2 in oral cancer cells.
    Int J Mol Sci 19:2907, 2018. DOI:10.3390/ijms19102907
  269. Jin F, Li X, Deng Y, Timilshina M, Huang B, Kim DY, Chang JH, Ichinose H, Baek SH, Murakami M, Lee YJ, Chang HW
    The orphan nuclear receptor NR4A1 promotes FcepsilonRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis.
    Allergy 74(6):1145-1156, 2018. DOI:10.1111/all.13702
  270. Okumura K, Saito M, and Wakabayashi Y.
    The role of PTH in mouse skin tumorigenesis.
    Integrative Cancer Science and Therapeutics 5:2, 2018. DOI:10.15761/ICST.1000271
  271. Kawamura Y, Yamanaka K, Poh B, Kuribayashi H, Koso H, Watanabe S
    The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development.
    Biochem Biophys Res Commun 503(4):3023-3030, 2018. DOI:10.1016/j.bbrc.2018.08.088
  272. M. Ishido*
    The temporal turning window for rat behavioral phenotypes by rotenone.
    Fund. Toxicol. Sci. 5, 2018.
  273. Ihara T,Mitsui T,Nakamura Y,Kanda M,Tsuchiya S,Kira S,Nakagomi H,Sawada N,kamiyama M, Shigetomi E,Shinozaki Y,Yoshiyama M,Nakao A,Takeda M,Koizumi S.
    The time-dependent variation of ATP release in mouse primary-cultured urothlial cells is regulated by the clock gene.
    Neurourol Urodym. 37:2535-2543, 2018. DOI:10.1002/nau.23793
  274. Futakuchi M, Nitanda T, Ando S, Matsumoto H, Yoshimoto E, Fukamachi K, Suzui M
    Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment.
    Int J Mol Sci 19(3), 2018. DOI:10.3390/ijms19030888
  275. Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama S
    Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells.
    Scientific Reports 8:6760, 2018. DOI:10.1038/s41598-018-25189-y
  276. Ohto, U., H. Ishida, T. Shibata, R. Sato, K. Miyake, and T. Shimizu.
    Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.?.
    Immunity 48(4):649-658, 2018. DOI:10.1016/j.immuni.2018.03.013
  277. Kurihara Y, Makita Y, Kawashima M, Fujita T, Iwasaki S, and Matsui M.
    Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis.
    Proc Natl Acad Sci USA 115(30):7831-7836, 2018. DOI:10.1073/pnas.1804971115
  278. Maeda A, Nishino T, Matsuzaki R, Yokoyama A, Suga H, Yagi T, Konishi H.
    Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling.
    Biochim Biophys Acta Mol Cell Res. 1866:285-295, 2018. DOI:10.1016/j.bbamcr.2018.11.009
  279. Momohara Y., Aonuma H. and Nagayama T.
    Tyraminergic modulation of agonistic outcomes in crayfish.
    J. Comp. Physiol. 204:465-473, 2018. DOI:10.1007/s00359-018-1255-3
  280. Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.
    UBL3 modification influences protein sorting to small extracellular vesicles.
    Nature Communications 9:3936, 2018. DOI:10.1038/s41467-018-06197-y
  281. Taiwa K, Yokoi S, Mito M2, Fujii K, Kimura Y, Iwasaki S, Nakagawa S.
    UPA-Seq: Prediction of Functional LncRNAs Using Differential Sensitivity to UV Crosslinking.
    RNA 24(12):1785-1802., 2018. DOI:10.1261/rna.067611.118
  282. Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Nameta M, Zhang L, Iwakura Y, Nawa H, Higuchi M, Komatsu M, Fujii M.
    USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis.
    iScience. 9:433-450, 2018. DOI:10.1016/j.isci.2018.11.006
  283. Shimizu A, Zankov DP, Kurokawa-Seo M, Ogita H.
    Vascular endothelial growth factor-A exerts diverse cellular effects via small G proteins, Rho and Rap.
    Int J Mol Sci 19:E1203, 2018. DOI:10.3390/ijms19041203
  284. Huizi Li, Aya Sugyo, Atsushi Tsuji, Yukie Morokoshi, Katsuyuki Minegishi, Kotaro Nagatsu, Hiroaki Kanda, Yosuke Harada, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Tatsuya Higashi, Sumitaka Hasegawa
    α-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibody against frizzled homolog 10.
    Cancer Science 109(7):2302-2309, 2018. DOI:10.1111/cas.13636
  285. Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H.
    β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.
    PLoS ONE 13(5):e0196946, 2018. DOI:10.1371/journal.pone.0196946
  286. 佐藤信吾
    がん骨転移のメカニズムの新知見と創薬への可能性.
    PHARM STAGE 18(3):54-58, 2018.
  287. 佐藤信吾
    がん細胞由来分泌型マイクロRNAが造骨型骨転移を惹起する.
    臨床雑誌整形外科 69(11):1124, 2018.
  288. Kojiro Ishibashi, Riku Egami, Kazuki Nakai, Shunsuke Kon
    がん変異細胞が産生されたときの代謝変化に関する総説.
    Cell Structure and Function 43:171-176, 2018. DOI:10.1247/csf.18018
  289. Vu HT, Kobayashi M, Hegazy AM, Tadokoro Y, Ueno M, Kasahara A, Takase Y, Nomura N, Peng H, Ito C, Ino Y, Todo T, Nakada M, Hirao A.
    グリオーマ幹細胞の治療抵抗性におけるオートファジーの役割.
    Cancer Sci 109:2497-2508, 2018. DOI:10.1111/cas.13695
  290. 和田裕一, 三浦知志, 窪俊一
    マンガの読みにおける状況モデルの更新.
    マンガ研究 24:93-114, 2018.
  291. 外川 龍之介, 奥畑 大悟, 吉田 侑冬,中尾 光之, 片山 統裕
    眼位・瞳孔径変動を考慮した内因性光信号イメージングに基づく覚醒時マウス脳視野地図の推定.
    生体医工学 :in press, 2018.
  292. Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi N, Hirao A
    高脂肪食ストレスによる幹細胞制御の破綻.
    Cell Stem Cell 22:713-725, 2018. DOI:10.1016/j.stem.2018.04.002
  293. Zhang Y, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Yamamori H, Boku S, Horai T, Someya T, Ohmori T, Hashimoto R, Sora I
    高齢の統合失調症におけるより長いテロメアと、日本人の長期入院との関連.
    J Psychiatr Res. 103:161-166, 2018. DOI:10.1016/j.jpsychires.2018.05.014
  294. Shunsuke Kon.
    細胞競合の生理的、病理的な役割に関する総説.
    Development, Growth and Differentiation 60:14-20, 2018. DOI:10.1111/dgd.12415
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    細胞突起形成抑制による膠芽腫治療戦略.
    新潟県医師会報 814(1):9-10, 2018.
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    胎児期栄養は発達障害の環境要因となりうるのか.
    日本衛生学雑誌 73:97-100, 2018. DOI:10.1265/jjh.73.97
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    超低周波電磁界の神経幹細胞に及ぼす影響評価に関する研究.
    磁気と健康 30:20-25, 2018.
  298. Nakamura S, Koyama T, Izawa N, Nomura S, Fujita T, Omata Y, Minami T, Matsumoto M, Nakamura M, Fujita-Jimbo E, Momoi T, Miyamoto T, Aburatani H, Tanaka S
    Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.
    PLoS One 12(4):e0175632, 2017. DOI:10.1371/journal.pone.0175632

2017年度

  1. Kotaki R, Kawashima M, Yamamoto Y, Higuchi H, Nagashima E, Kurosaki N, Takamatsu M, Kikuti YY, Imadome KI, Nakamura N, Kotani A.
    Dasatinib exacerbates splenomegaly of mice inoculated with Epstein-Barr virus-infected lymphoblastoid cell lines.
    Sci Rep. 10(1):4355, 2020.
  2. T. Yamada, A. Tanaka, T. Nehira, T. Nishii, T. Kikuchi
    Altercrasins A-E, decalin derivatives, from a sea-urchin-derived Alternaria sp.: isolation and structural analysis including stereochemistry.
    Marine Drugs 17:218, 2019. DOI:10.3390/md17040218
  3. T. Yamada, A. Fujii, T. Kikuchi
    New diterpenes with a fused 6-5-6-6 ring system isolated from the marine sponge-derived fungus Trichoderma harzianum.
    Marine Drugs 17:480, 2019. DOI:10.3390/md17080480
  4. Ito T, Oti T, Takanami K, Satoh K, Ueda Y, Sakamoto T, Sakamoto H.
    A sexually dimorphic peptidergic system in the lower spinal cord controlling penile function in non-human primates.
    Spinal cord 56(1):57-62, 2018. DOI:10.1038/sc.2017.105
  5. Yamada T, Imamachi N, Onoguchi-Mizutani R, Imamura K, Suzuki Y, Akimitsu N
    5'-Bromouridine IP Chase (BRIC)-Seq to Determine RNA Half-Lives.
    Methods Mol Biol 1720:1-13, 2018. DOI:10.1007/978-1-4939-7540-2_1
  6. Inoue D, Fujino T, Sheridan P, Zhang Yz, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata KC, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang FC, Oyama M, Kitamura T
    A novel ASXL1?OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.
    Leukemia 32(6):1327-1337, 2018. DOI:10.1038/s41375-018-0083-3
  7. Meikui Wu,Makoto Takemoto,Huan Luo,Jian-Jun Xu,Mei-Hong Lu,Masaki Kameyama,Toru Takumi,Wen-Jie Song.
    A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1.
    Eur J Pharmacology 824:99-107, 2018. DOI:10.1016/j.ejphar.2018.02.013
  8. Shinno, N., Kimura, H., Sada, R., Takiguchi, S., Mori, M., Fumoto, K., Doki, Y., and Kikuchi, A.
    Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.
    Oncogene 37:6107-6120, 2018. DOI:10.1038/s41388-018-0179-2
  9. Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y, Muto A, Okano H,?Yamanaka A, Tawfik VL, Kuzumaki N, Navratilova E, Porreca F, *Narita M.
    Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer.
    Molecular Pain 14:1744806918756400, 2018. DOI:10.1177/1744806918756406
  10. Ueno H, Takao K, Suemitsu S, Murakami S, Kitamura N, Wani K, Okamoto M, Aoki S, Ishihara T
    Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex.
    Neurochem Int 112:59-70, 2018. DOI:10.1016/j.neuint
  11. Hashimoto M, Yamanaka A, Kato S, Tanifuji M, Kobayashi K, Yaginuma H.
    Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus.
    Frontiers in Neural Circuit 12:6, 2018. DOI:10.3389/fncir.2018.00006
  12. Sobue A, Ito N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K.
    Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes.
    Glia 66:1034-1052, 2018. DOI:10.1002/glia.23299
  13. Kitamura T.
    ASXL1 mutations gain a function.
    Blood 131(3):274-275, 2018. DOI:10.1182/blood-2017-12-816595
  14. Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR.
    Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.
    EMBO J. , 2018. DOI:10.15252/embj.201797858
  15. Moriguchi S, Ishizuka T, Yabuki Y, Shioda N, Sasaki Y, Tagashira H, Yawo H, Yeh JZ, Sakagami H, Narahashi T, Fukunaga K.
    Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy.
    Mol Psychiatry. 23(2):211-221, 2018. DOI:10.1038/mp.2016.187
  16. Hayashida T, Saito Y, Ishii A, Yamada H, Itakura A, Minato T, Fukuyama T, Maegaki Y, Hirose S.
    CACNA1A-related early-onset encephalopathy with myoclonic epilepsy: A case report.
    Brain & Development 40(2):130-133, 2018. DOI:10.1016/j.braindev.2017.08.006
  17. Hashimoto K, Ochi H, Sunamura S, Kosaka N, Mabuchi Y, Fukuda T, Yao K, Kanda H, Ae K, Okawa A, Akazawa C, Ochiya T, Futakuchi M, Takeda S, Sato S
    Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A.
    Proc Natl Acad Sci U S A 115(9):2204-2209, 2018. DOI:10.1073/pnas.1717363115
  18. Mito M., Kadota M., Tanaka K., Furuta Y., Abe K., Iwasaki S.*, and Nakagawa S.
    Cell-type specific survey of epigenetic modifications by tandem chromatin immunoprecipitation sequencing.
    Scientific Reports 8:1143, 2018. DOI:10.1038/s41598-018-19494-9
  19. Nakamura, Y., Nakamura, K.
    Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability.
    Pfl?gers Archiv - European Journal of Physiology 470:823-837, 2018. DOI:10.1007/s00424-017-2090-z
  20. Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, Nabeshima T.
    Cerebellar α6 subunit-containing GABAA receptors: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders.
    Br J Pharmacol. 175(12):2414-2427, 2018. DOI:10.1111/bph.14198
  21. Sakai E., Nakayama M., Oshima H., Kouyama Y., Niida A., Fujii S., Ochiai A., Nakayama KI., Mimori K., Suzuki Y., Hong CP., Ock CY., Kim SJ., Oshima M.
    Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.
    Cancer Res. 78(5):1334-1346, 2018. DOI:10.1158/0008-5472.CAN-17-3303
  22. Kaizuka T, Hayashi T
    Comparative analysis of palmitoylation sites of serotonin (5-HT) receptors in vertebrates.
    Neuropsychopharmacology Reports 38:75-85, 2018. DOI:10.1002/npr2.12011
  23. Hagihara H., Catts VS., Katayama Y., Shoji H., Takagi T., Huang FL., Nakao A., Mori Y., Huang KP., Ishii S., Graef IA., Nakayama KI., Shannon Weickert C., Miyakawa T.
    Decreased brain pH as a shared endophenotype of psychiatric disorders.
    Neuropsychopharmacology 43:459-68, 2018. DOI:10.1038/npp.2017.167
  24. *Fakruddin M, *Wei FY, Suzuki T, Asano K, Kaieda T, Omori A, Izumi R, Fujimura A, Kaitsuka T, Miyata K, Araki K, Oike Y, Scorrano L, Suzuki T, Tomizawa K.
    Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
    Cell Rep 22:482-496, 2018.
  25. Nakayama S., Yumimoto K., Kawamura A., Nakayama KI.
    Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7?in a manner dependent on the kinase GSK-3.
    J. Biol. Chem. 293(15):5705-5714, 2018. DOI:10.1074/jbc.RA117.000741
  26. Eisuke Sato, Maho Morita, Haruo Ogawa, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Satoshi ?mura, Arihiro Iwasaki and Kiyotake Suenaga
    Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ pump inhibitor from marine cyanobacteria.
    Bioorganic & Medicinal Chemistry Letters 28 (3):298-301, 2018. DOI:10.1016/j.bmcl.2017.12.050
  27. Suda Y, Kuzumaki N, Narita M, Hamada Y, Shibasaki M, Tanaka K, Tamura H, Kawamura T, Kondo T,?Yamanaka A, *Narita M.
    Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors.
    Biochemical and Biophysical Research Communications? 496(4):1102-1108, 2018. DOI:10.1016/j.bbrc.2018.01.145
  28. Kusumoto Y, Okuyama H, Shibata T, Konno K, Takemoto Y, Maekawa D, Kononaga T, Ishii T, Akashi-Takamura S, Saitoh SI, Ikebuchi R, Moriya T, Ueda M, Miyake K, Ono S, Tomura M.
    Epithelial Membrane Protein 3 (Emp3) Downregulates Induction and Function of Cytotoxic T Lymphocytes by Macrophages via TNF-α Production.
    Cell Immunol. 30(2):43-51, 2018. DOI:10.1016/j.cellimm.2017.12.001
  29. Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, Fujii T, Kakuta S, Kubo S, Shibata T, Yamaguchi K, Iwakura Y, Furukawa Y.
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  264. T. Watanabe, Y. Mutoh, S. Saito
    Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylanilides: Synthesis of 3-Substituted Indoles by 1,2-Carbon Migration.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139:7749-7752, 2017. DOI:10.1021/jacs.7b04564
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    Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice.
    Lipids Health Dis. 16:106, 2017. DOI:10.1186/s12944-017-0501-y
  266. Sumi-Ichinose C, Suganuma Y, Kano T, Ihira N, Nomura H, Ikemoto K, Hata T, Katoh S, Ichinose H, Kondo K
    Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia.
    Physiol Rep 5:e13196, 2017. DOI:10.14814/phy2.13196
  267. Shibata Y, Hara T, Matsumoto T, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Goto N, Nannya Y, Ito H, Kito Y, Miyazaki T, Takeuchi T, Saito K, Seishima M, Takami T, Moriwaki H, Shimizu M, Tsurumi H.
    Serum concentrations of l-kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified.
    Hematol Oncol 35:637-644, 2017. DOI:10.1002/hon.2318
  268. Kiyokawa H, Yasuda H, Oikawa R, Okuse C, Matsumoto N, Ikeda H, Watanabe T, Yamamoto H, Itoh F, Otsubo T, Yoshimura T, Yoshida E, Nakagawa M, Koshikawa N & Seiki M
    Serum monomeric laminin-gamma2 as a novel biomarker for hepatocellular carcinoma.
    Cancer Science 108:1432-1439, 2017. DOI:10.1111/cas.13261
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    SEVEN FAMILIAL DYSALBUMINEMIC HYPERTHYROXINEMIA CASES IN THREE UNRELATED JAPANESE FAMILIES AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ANALYSIS OF THE THYROXINE BINDING PROFILE.
    Endocr Pract 23(11):1325-1332, 2017. DOI:10.4158/EP171964.OR
  270. Yaguchi H., Yabe I., Takahashi H., Watanabe M., Nomura T., Kano T., Matsumoto M., Nakayama KI., Watanabe M., Hatakeyama S.
    Sez6l2 regulates phosphorylation of ADD and neuritogenesis.
    Biochem. Biophys. Res. Commun. 494:234-41, 2017. DOI:10.1016/j.bbrc.2017.10.047
  271. Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K
    SIRT7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
    Biochem Biophys Res Commun 490:423-428, 2017. DOI:10.1016/j.bbrc.2017.06.057
  272. Satoko Suzuki, Noriko Ayukawa, Chisa Okada, Masami Tanaka, Susumu Takekoshi, Yoko Iijima, and Takatoshi Iijima.
    Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons.
    Scientific Reports 7:11405, 2017. DOI:10.1038/s41598-017-11319-5
  273. Higuchi T, Ishizaki Y, Noritake A, Yanagimoto Y, Kobayashi H, Nakamura K, Kaneko K.
    Spatiotemporal characteristics of gaze of children with autism spectrum disorders while looking at classroom scenes.
    PLoS ONE 12(5), 2017. DOI:10.1371/journal.pone.0175912
  274. Shuji Wakatsuki, Toshiyuki Araki
    Specific phospholipid scramblases are involved in exposure of phosphatidylserine, an "eat-me" signal for phagocytes, on degenerating axons.
    Commun Integr Biol 17:e1296615, 2017. DOI:10.1080/19420889.2017.1296615
  275. Ryo Watanabe, Haruki Mizoguchi, Hideaki, Oikawa, Hirofumi Ohashi, Koichi Watashi, HirokiOguri
    Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents.
    Bioorg. Med. Chem. 25(11):2851-2855, 2017. DOI:10.1016/j.bmc.2017.03.011
  276. Kimiko Shimizu and Yoshitaka Fukada
    Stereotaxic Surgery for Suprachiasmatic Nucleus Lesions in Mice.
    Bio-protocol 7:2346, 2017. DOI:10.21769/BioProtoc.2346
  277. Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H
    Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor.
    Neuroscience Letters 654:99-106, 2017. DOI:10.1016/j.neulet.2017.06.005
  278. Yonehara R., Nada S., Nakai T., Nakai M., Kitamura A., Ogawa A., Nakatsumi H., Nakayama KI., Li S., Standley DM., Yamashita E., Nakagawa A., Okada M.
    Structural basis for the assembly of the Ragulator-Rag GTPase complex.
    Nature Commun. 8:1625, 2017. DOI:10.1038/s41467-017-01762-3
  279. K. Ito, Y. Mutoh, S. Saito
    Synthesis of [2]Catenanes by Intramolecular Sonogashira-Type Reaction.
    JOURNAL OF ORGANIC CHEMISTRY 82:6188-6124, 2017. DOI:10.1021/acs.joc.7b00672
  280. Yamazaki, Y.; Mutoh, Y.; Saito, S.
    Synthesis of Interlocked Compounds by Utilizing Bond-forming Reactions Mediated by Macrocyclic Phenanthroline-Cu Complexes.
    CHEMISTRY LETTERS 46:904-912, 2017. DOI:10.1246/cl.170031
  281. Y. Mochizuki, K. Ikeyatsu, Y. Mutoh, S. Hosoya, S. Saito
    Synthesis of Mechanically Planar Chiral rac-[2]Rotaxanes by Partitioning of an Achiral [2]Rotaxane: Stereoinversion Induced by Shuttling.
    ORGANIC LETTERS 19:4347-4350, 2017. DOI:10.1021/acs.orglett.7b02043
  282. Nakamura T, Okabe S, Yoshida H, Iida K, Ma Y, Sasaki S, Yamori T, Shin-Ya K, Nakano I, Nagasawa K, Seimiya H.
    Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole.
    Scientific Reports 7:e3605, 2017. DOI:10.1038/s41598-017-03785-8
  283. Aizawa F, Ogaki Y, Kyoya N, Nakamoto K, Kurihara T, Hirasawa A, Miyata A, Tokuyama S,
    The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice.
    Biol Pharm Bull 40:1255-1259, 2017. DOI:10.1248/bpb.b17-00082
  284. Park S, Mori R, Shimokawa I
    The fat regulator neuropeptide Y and caloric restriction.
    Aging (Albany NY) 9(11):2243-2244, 2017. DOI:10.18632/aging.101338
  285. Nobuhiko Takai, Masatsugu Ohgami, Koichi Ando, Akiko Uzawa, Ryoichi Hirayama, Saori Nakamura, Yoshihito Ohba
    THE FOCAL BRAIN IRRADIATION OF PROTON BEAM INSULT IN RATS INDUCED MEMORY DISTURBANCE RELATED CHANGE IN ACETYLCHOLINE RECEPTOR BINDING.
    RadProc vol.2:25-29, 2017. DOI:10.21175
  286. Mouri A, Noda Y, Niwa M, Matsumoto Y, Mamiya T, Nitta A, Yamada K, Furukawa S, Iwamura T, Nabeshima T.
    The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization.
    Behav Brain Res. 329:157-165, 2017. DOI:10.1016/j.bbr.2017.04.052
  287. Yahiro, T., Kataoka, N., Nakamura, Y., Nakamura, K.
    The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation.
    Scientific Reports 7:5031, 2017. DOI:10.1038/s41598-017-05327-8
  288. Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I, Wakana S, Yamaguchi M, Shitara H, Taya C, Karaplis AC, Kominami R, and Wakabayashi Y
    The parathyroid hormone regulates skin tumour susceptibility in mice.
    Scientific Reports 7(1):11208, 2017. DOI:10.1038/s41598-017-11561-x
  289. Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I, Wakana S, Yamaguchi M, Shitara H, Taya C, Karaplis AC, Kominami R, and Wakabayashi Y.
    The parathyroid hormone regulates skin tumour susceptibility in mice.
    Scientific Reports 7 (1):11208, 2017.
  290. Murakami Y, Fukui R, Motoi Y, Shibata T, Saitoh SI, Sato R, Miyake K.
    The Protective Effect of the anti-Toll-like Receptor 9 Antibody Against Acute Cytokine Storm Caused by Immunostimulatory DNA.
    Sci Rep 7:44042, 2017. DOI:10.1038/srep44042
  291. Kake S, Tsuji S, Enjoji S, Hanasaki S, Hayase H, Yabe R, Tanaka Y, Nakagawa T, Liu HP, Chang SC, Usui T, Ohama T*, Sato K
    The Role of SET/I2PP2A in canine mammary tumors.
    Scientific Reports 27:4279, 2017. DOI:10.1038/s41598-017-04291-7
  292. Takakura Y, Yamaguchi N, Honda T, Morii M, Yuki R, Nakayama Y, Yamaguchi N
    The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALK(ATI)) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner.
    Biol Pharm Bull. 40(11):1968-1975, 2017. DOI:10.1248/bpb.b17-00548
  293. Yuichiro Yoneoka, Junichi Yoshimura, Masakazu Sano, Masayasu Okada, Akiyoshi Kakita, Yukihiko Fujii
    Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement.
    Pediatr Neurosurg. 53(1):49-54, 2017. DOI:10.1159/000480021
  294. Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI.
    Thymidine Catabolism as a Metabolic Strategy for Cancer Survival.
    Cell Reports 19:1313-1321, 2017. DOI:10.1016/j.celrep.2017.04.061
  295. Ogura H, Nagatake-Kobayashi Y. Adachi J, Tomonaga T, Fujita N, *Katayama R.
    TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity.
    Scientific Reports 7:5519, 2017. DOI:10.1038/s41598-017-05736-9
  296. Saitoh S, Abe F, Kanno A, Tanimura N, Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K, and Miyake K
    TLR7 Mediated Viral Recognition Results in Focal Type I Interferon Secretion by Dendritic Cells.
    Nat. Commun. 8(1):1592, 2017. DOI:10.1038/s41467-017-01687-x
  297. Eisuke Sato, Miho Sato, Yurika Tanabe, Naoya Nakajima, Akifumi Ohkubo, Kiyotake Suenaga
    Total Synthesis of Biselyngbyaside.
    The Jornal of Organic Cehmistry 82 (13):6770-6777, 2017. DOI:10.1021/acs.joc.7b00905
  298. Wong-Lin K, Wang DH, Moustafa AA, Cohen JY, Nakamura K.
    Toward a multiscale modeling framework for understanding serotonergic function.
    Journal of psychopharmacology 31(9):1121-1136, 2017. DOI:10.1177/0269881117699612
  299. Magi S, Iwamoto K, Yumoto N, Hiroshima M, Nagashima T, Ohki R, Garcia-Munoz A, Volinsky N, Kriegsheim AV, Sako Y, Takahashi K, Kimura S, Kholodenko BN, Okada-Hatakeyama M
    Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization.
    J Biol Chem 293:2206-2218., 2017. DOI:10.1074/jbc.M117.778399
  300. Nomiyama H, Osada N, Takahashi I, Terao K, Yamagata K, Yoshie O
    Translational repression of a splice variant of cynomolgus macaque CKCL1L by its C-terminal sequence.
    Journal of Interferon and Cytokine Research 37:129-138, 2017. DOI:10.1089/jir.2016.0085
  301. Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K*.
    Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
    Exp Neurol 293:1-12, 2017. DOI:10.1016/j.expneurol.2017.03.009
  302. Kano M, Watanabe T
    Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease.
    F1000Research 6:416, 2017. DOI:10.12688/f1000research.10485.1
  303. Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R.
    Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.
    Cell Res. 27:657-6674, 2017. DOI:10.1038/cr.2017.40
  304. Oh Y-M, Karube F…Fujiyama F. et al.
    Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations.
    Brain Struct Funct 222:2359-2378, 2017. DOI:10.1007/s00429-016-1346-2
  305. Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T.
    Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.
    JCI Insight 2(1):e89462, 2017. DOI:10.1172/jci.insight.89462
  306. Honda T, Morii M, Nakayama Y, Suzuki K, Yamaguchi N, Yamaguchi N
    v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling.
    Sci Rep. 8:1063, 2017. DOI:10.1038/s41598-018-19599-1
  307. Aonuma H., Kaneda M., Hatakeyama D., Watanabe T., Lukowiak K. and Ito E.
    Weak involvement of octopamine in aversive taste learning in a snail.
    Neurobiol. Learn. Mem. 141:189-198, 2017. DOI:10.1016/j.nlm.2017.04.010
  308. 斎藤慎一, 片村友大, 武藤雄一郎
    アジリジン,アゼチジンの環拡大反応を利用したN-ヘテロ環合成法の開発.
    有機合成化学協会誌 75:340-348, 2017. DOI:10.5059/yukigoseikyokaishi.75.340
  309. 山中章弘
    オレキシン神経活動操作による機能解明.
    睡眠医療 11(1):19-25, 2017.
  310. 設樂久志,小川宏人
    コオロギの音源定位ナビゲーション-神経行動学が迫る動物のナビゲーションメカニズム.
    生物の科学 遺伝 71:519-525, 2017.
  311. Iijima J, Kobayashi S, Kitazume S, Kizuka Y, Fujinawa R, Korekane H, Shibata T, Saitoh SI, Akashi-Takamura S, Miyake K, Miyoshi E, Taniguchi N.
    タンパク質におけるフコース修飾の意義の解析.
    Glycobiology 27(11):1006-1015, 2017. DOI:10.1093/glycob/cwx075
  312. Sato R*, Shibata T*, Tanaka Y, Kato C, Yamaguchi K, Furukawa Y, Shimizu E, Yamaguchi R, Imoto S, Miyano S, Miyake K. (* equally contributed)
    ノックアウトライブラリーを用いた分子探索.
    Int Immunol 29(8):347-355, 2017. DOI:10.1093/intimm/dxx044
  313. 河原康一、古川龍彦
    核小体によるp53制御とがん治療薬開発の新展開.
    実験医学 35:2365-2367, 2017.
  314. 山中章弘
    光遺伝学による神経科学研究の新展開.
    医学のあゆみ 262(5):491-495, 2017.
  315. 山中章弘
    光遺伝学による睡眠覚醒の制御.
    生体の科学 65(5):484-485, 2017.
  316. Otsuka I, Izumi T, Boku S, Kimura A, Zhang Y, Mouri K, Okazaki S, Shiroiwa K, Takahashi M, Ueno Y, Shirakawa O, Sora I, Hishimoto A.
    自殺既遂者におけるテロメア長とミトコンドリアDNAコピー数の研究.
    Sci Rep. 7(1):31-76, 2017.
  317. 山中章弘
    睡眠のマニピュレーション-光遺伝学、薬理遺伝学を用いた睡眠覚醒の操作.
    医学のあゆみ 263(9):765-774, 2017.
  318. Wu MK, Takemoto M, Taniguchi M, Takumi T, Okazaki T, Song W-J.
    Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1.
    American Journal of Physiology-Cell Physiology 311(1):C15-23, 2016. DOI:10.1152/ajpcell.00272.2015
  319. 岡田正康
    軸索再生に対するGAP-43の機能解明:GAP-43 (Ser96)のリン酸化は軸索再生の分子マーカーとなる.
    新潟医学会雑誌 130(7):405-419, 2016.
  320. Katsutoshi Imamura, Akiko Takaya, Yo-ichi Ishida, Yayoi Fukuoka, Toshiki Taya, Ryo Nakaki, Miho Kakeda, Naoto Imamachi, Aiko Sato, Toshimichi Yamada, Yutaka Suzuki, Masami Nagahama, Tomoko Yamamot, Torben Heick Jensen, Nobuyoshi Akimitsu
    Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs.
    EMBO Journal

2016年度

  1. Hiroshi Fukamachi, Seon-Kyu Kim, Jiwon Koh, Hye Seung Lee, Yasushi Sasaki, Kentaro Yamashita, Taketo Nishikawaji, Shu Shimada, Yoshimitsu Akiyama, Sun-ju Byeon, Dong-Hyuck Bae, Keisuke Okuno, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Hiroshi Kawachi, Kiichiro Tsuchiya, Kazuyuki Kojima, Takashi Tokino, Yoshinobu Eishi, Yong Sung Kim, Woo Ho Kim, Yasuhito Yuasa, and Shinji Tanaka
    A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors.
    Journal of Experimental & Clinical Cancer Research 38:127, 2019. DOI:10.1186/s13046-019-1121-3
  2. Kanetake T, Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, Kihara A
    Neural symptoms in a gene knockout mouse model of Sj?gren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide.
    FASEB Journal 33:928-941, 2019. DOI:10.1096/fj.201800291R
  3. Kasahara Y, Sakakibara Y, Hiratsuka T, Moriya Y, Lesch KP, Hall FS, Uhl GR, Sora I
    Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice.
    Neuropsychopharmacology Reports 39:130-133, 2019. DOI:10.1002/npr2.12049
  4. Kano T., Sato E., Ono T., Aonuma H., Matsuzaka Y. and Ishiguro A.
    A brittle star-like robot capable of immediately adapting to unexpected physical damage.
    Royal Soc. Open Sci. 4:171200, 2018. DOI:10.1098/rsos.171200
  5. Sumitani M, Nishizawa D, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
    Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain.
    Pain Medicine 19:348-354, 2018. DOI:10.1093/pm/pnx102
  6. DiRienzo, N. and Aonuma H.
    Plasticity in extended phenotype increases offspring defense despite individual variation in web structure and behavior.
    Animal Behav. 138:9ー17, 2018. DOI:10.1016/j.anbehav.2018.01.022
  7. Kai Kitamura, Hiroaki Itoh, Kaori Sakurai, Shingo Dan, Masayuki Inoue
    Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase.
    Journal of the American Chemical Society 140(38):12189-12199, 2018. DOI:10.1021/jacs.8b07339
  8. Motohiro Nozumi, Michihiro Igarashi
    Vesicular movements in the growth cone.
    Neurochemistry International 119:71-76, 2018. DOI:10.1016/j.neuint.2017.09.011
  9. Shiratori C., Suzuki N., Momohara Y., Shiraishi K., Aonuma H., and Nagayama T.
    Cyclic AMP-regulated opposing and parallel effects of serotonin and dopamine on phototaxis in the Marmorkrebs (marbled crayfish).
    Europ. J. Neurosci. 46:1863-1874, 2017. DOI:10.1111/ejn.13632
  10. Saito T, Ishii A, Sugai K, Sasaki M, Hirose S.
    A de novo missense mutation in SLC12A5 found in a compound heterozygote patient with epilepsy of infancy with migrating focal seizures.
    Clinical Genetics 92(6):654-658, 2017. DOI:10.1111/cge.13049
  11. Matsumoto M., Matsuzaki F., Oshikawa K., Goshima N., Mori M., Kawamura Y., Ogawa K., Fukuda E., Nakatsumi H., Natsume T., Fukui K., Horimoto K., Nagashima T., Funayama R., Nakayama K. & Nakayama KI.
    A large-scale targeted proteomics assay resource based on an in vitro human proteome.
    Nature Methods 14:251-8, 2017. DOI:10.1038/nmeth.4116
  12. Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, *Komatsu M.
    A novel approach to assess the ubiquitin-fold modifier 1-system in cells.
    FEBS Lett. 591:196-204, 2017. DOI:10.1002/1873-3468.12518
  13. Uchida T, Lossin C, Ihara Y, Deshimaru M, Yanagawa Y, Koyama S, Hirose S.
    Abnormal gamma-aminobutyric acid neurotransmission in a Kcnq2 model of early onset epilepsy.
    Epilepsia 58(8):1430-1439, 2017. DOI:10.1111/epi.13807
  14. Ayumi Hashimoto, Toyohiro Sawada, Itsuki Kageyama, Kiyohisa Natsume
    Activation of the muscarinic receptors induces the transition of the epileptic discharges to beta oscillation in hippocampal slices.
    Biophysics_and Physicobiology 14:137-146, 2017. DOI:10.2142/biophysico.14.0_137
  15. *Ueno T, *Komatsu M.
    Autophagy in the liver: functions in health and disease.
    Nat Rev Gastroenterol Hepatol. 14:170-184, 2017. DOI:10.1038/nrgastro.2016.185
  16. Uchibori K, Inase N, Araki M, Kamada M, Sato S, Okuno Y, Fujita N, *Katayama R.
    Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer.
    Nature communications 8:14768, 2017. DOI:10.1038/ncomms14768
  17. Sho Wakayama, Shigeki Kiyonaka, Itaru Arai, Wataru Kakegawa, Shinji Matsuda, Keiji Ibata, Yuri L. Nemoto, Akihiro Kusumi, Michisuke Yuzaki & Itaru Hamachi
    Chemical labeling for visualizing native AMPA receptors in live neurons.
    Nature Communications 8:e14850, 2017. DOI:10.1038/ncomms14850
  18. Ishii A, Watkins JC, Chen D, Hirose S, Hammer MF.
    Clinical implications of SCN1A missense and truncation variants in a large Japanese cohort with Dravet syndrome.
    Epilepsia 58(2):282-290, 2017. DOI:10.1111/epi.13639
  19. Jun Nakayama, Emi Ito, Jiro Fujimoto, Shinya Watanabe and Kentaro Semba
    Comparative analysis of gene regulatory networks of highly metastatic breast cancer cells established by orthotopic transplantation and intra-circulation injection.
    International Journal of Oncology 50.2:497-504, 2017. DOI:10.3892/ijo.2016.3809
  20. Nozumi M, Nakatsu F, Katoh K, *Igarashi M
    Coordinated movement of vesicles and actin bundles during nerve growth revealed by superresolution microscopy.
    Cell Rep 18:2203-2216, 2017. DOI:10.1016/j.celrep.2017.02.008
  21. Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
    Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.
    J Clin Endocrinol Metab 101(3):841-6, 2017. DOI:10.1210/jc.2015-2855
  22. Goto E, Tokunaga F.
    Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.
    Biochemical and Biophysical Research Communications 485(1):152-159, 2017. DOI:10.1016/j.bbrc.2017.02.040
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