成果論文リスト
本支援による成果を含む論文として支援依頼者から報告があった論文を成果が得られた年度順に並べました。成果論文には「先端モデル動物支援」の課題番号「22H04922」を謝辞に入れることをお願いしていますが、課題番号の記載がない論文も含めています。
2021年度
- Sakamoto M, Inoue M, Takeuchi A, Kobari S, Yokoyama T, Horigane S, Takemoto-Kimura S, Abe M, Sakimura K, Kano M, Kitamura K, Fujii H, Bito H.
A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo.
Cell Reports Methods 2022;2:100168. DOI:10.1016/j.crmeth.2022.100168 - Shinji Kishimoto, Yuya Matsubara, Kenji Watanabe
Alkaloid biosynthetic enzyme generates diastereomeric pair via two distinct mechanisms.
Journal of the American Chemical Society 2022;144:5485-5493. DOI:10.1021/jacs.1c13621 - Akihito Yokosuka, Tatsuya Shimomura, Shohei Yokogawa, Airi Oguro, Katsunori Miyake, Yoshihiro Mimaki
Chemical components from Hedera rhombea leaves and their cytotoxicity.
Chemical and Pharmaceutical Bulletin 2022;70:175-181. DOI:10.1248/cpb.c21-00907 - Nae Saito, Makoto Itakura, Toshikuni Sasaoka
D1 Receptor Mediated Dopaminergic Neurotransmission Facilitates Remote Memory of Contextual Fear Conditioning.
Frontiers in Behavioral Neuroscience 2022;16:751053. DOI:10.3389/fnbeh.2022.751053 - 齊藤奈英、板倉誠、田井中一貴, Tom Macpherson, 疋田貴俊、山口瞬、佐藤朝子、大久保直、知見聡美、南部篤、笹岡俊邦
D1およびD2ドーパミン受容体を介する神経伝達による運動制御と学習記憶の仕組みの理解.
日本生物学的精神医学会誌 2022;33:in press. - Saegusa J, Osada Y, Miura K, Sasazawa Y, Ogura A, Takao KI, Simizu S.
Elucidation of structure-activity relationship of humulanolides and identification of humulanolide analog as a novel HSP90 inhibitor.
Bioorg Med Chem Lett 2022;60:128589. DOI:10.1016/j.bmcl.2022.128589 - Miura K, Kobayashi T, Zhang Z, Prasoon P, Hirose Y, Ishikawa H, Takizawa K, Sakata J, Miura S, Sasaoka T, Wakai T
Establishment of a long-term survival swine model for observation of transplanted islets: A preliminary step in an allogeneic transplant experiment.
Transplantation Proceedings 2022;54(2):507-512. DOI:10.1016/j.transproceed.2021.10.029 - Koji Kuraoka, Kae Nakamura
Facial temperature and pupil size as indicators of internal state in primates.
Neuroscience research 2022;175:25-37. DOI:10.1016/j.neures.2022.01.002 - Tanno N, Takemoto K, Takada-Horisawa Y, Shimada R., Fujimura S, Tani N., Takeda N., Araki K, Ishiguro K
FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis.
iScience 2022:in press. DOI:10.1016/j.isci.2022.104008 - Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Yurika Tokunaga, Yoshinori Hasegawa, Kimi Araki, Yuichi Wakabayashi
Functional polymorphism in Pak1-3'UTR alters skin tumor susceptibility by alternative polyadenylation.
Journal of Investigative Dermatology 2022:in press. - Yun-Wei Xue, Hiroaki Itoh, Shingo Dan, Masayuki Inoue
Gramicidin A Accumulates in Mitochondria, Reduces ATP Levels, Induces Mitophagy, and Inhibits Cancer Cell Growth.
Chemical Science 2022:in press. DOI:10.1039/D2SC02024F - Wang, X.-H., Abe, I., Morita, H., Tu, P.-F., Shi, S.-P. et al.
Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood.
Nature Commun. 2022;13:348. DOI:10.1038/s41467-022-27971-z - Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.
Identification of a small molecule that enhances ferroptosis via inhibition of ferroptosis suppressor protein 1 (FSP1).
ACS Chem Biol 2022;17:483-491. DOI:10.1021/acschembio.2c00028 - Apostolopoulos A and Iwasaki S
Into the matrix: current methods for mitochondrial translation studies.
J Biochem. 2022;171:379-387. DOI:10.1093/jb/mvac005 - Sasaki L*, Hamada Y*, Yarimizu D*, (20 people), Miyake T, Doi M#
*:co-first, #:corresponding
Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction.
Nature Aging 2022;2:105-114. DOI:10.1038/s43587-021-00167-8 - Kohda, Y., Sakamoto, S., Umekita, M., Kimura, T., Kubota, Y., Arisaka, R., Shibuya, Y., Muramatsu, H., Sawa, R., Dan, S., Kawada, M., Igarashi, M.
Isolation of new derivatives of the 20-membered macrodiolide bispolide from Kitasatospora sp. MG372-hF19.
The Journal of Antibiotics 2022;75:77-85. DOI:10.1038/s41429-021-00492-5 - Sonja Thölmann, Jochen Seebach, Tetsuhisa Otani, Luise Florin, Hans Schnittler, Volker Gerke, Mikio Furuse, Klaus Ebnet
JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells.
Cellular and Molecular Life Sciences 2022;79:1-19. DOI:10.1007/s00018-022-04140-5 - Okada M, Kawagoe Y, Takasugi T, Nozumi M, Ito Y, Fukusumi H, Kanemura Y, Fujii Y, Igarashi M
JNK1-dependent phosphorylation of GAP-43 Serine 142 is a novel molecular marker for axonal growth.
Neurochem Res 2022:in press. - Riki Furuhata, R., Imasaka, M., Sugimoto, M., Yoshinobu, K., Araki, M. and Araki, K.
LincRNA-p21 exon 1 expression correlates with Cdkn1a expression in vivo.
Genes to Cells 2022;27:14-24. DOI:10.1111/gtc.12906 - Liu N, Iijima A, Iwata Y, Ohashi K, Fujisawa N, Sasaoka T, Hasegawa I.
Mental construction of object symbols from meaningless elements by Japanese macaques (Macaca fuscata).
Scientific Reports 2022;12:3566. DOI:10.1038/s41598-022-07563-z - Tao, H.,# Mori, T.,# Chen, H., Lyu, S., Nonoyama, A., Lee, S., Abe, I. (#equall contribution)
Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/α-ketoglutarate-dependent oxygenase SptF.
Nature Commun 2022;13:95. DOI:10.1038/s41467-021-27636-3 - Sayaka Saijo, Mikiko Ohno, Hirotaka Iwasaki, Shintaro Matsuda, Kiyoto Nishi, Yoshinori Hiraoka, Natsuki Ide, Takeshi Kimura, Eiichiro Nishi
Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis.
Scientific Reports 2022;12:3449. DOI:10.1038/s41598-022-07379-x - N Kondo, Y Sakurai, T Takata, K Kano, K Kume, M Maeda, N Takai, S Suzuki et al.,
Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation.
scientific reports 2022;12:8718. DOI:10.1038/s41598-022-12293-3 - Miyajima K, Sudo Y, Sanechika S, Hara S, Inoue K, Takada M, Yoshioka N, Takebayashi H, Sugimoto M, Sumi-Ichinose C, Takao K, Miyakawa T, Ichinose H, et al.
Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin.
Journal of Neurochemistry 2022;161(2):129-145. DOI:10.1111/jnc.15600 - Megumi Saito, Akane Sada, Masaki Fukuyo, Kiyono Aoki, Kazuhiro Okumura, Yuko Tabata, Yu Chen, Atsushi Kaneda, Yuichi Wakabayashi, Rieko Ohki
PHLDA3 Is an Important Downstream Mediator of p53 in Squamous Cell Carcinogenesis.
Journal of Investigative Dermatology 2022;142:1040-1049. DOI:10.1016/j.jid.2021.09.007 - Mishima Y, Han P, Ishibashi K, Kimura S, and Iwasaki S
Ribosome slowdown triggers codon-mediated mRNA decay independently of ribosome quality control.
EMBO J. 2022;41(5):e109256. DOI:10.15252/embj.2021109256 - Miyake T, Doi M
Roles of the Circadian Clock Mechanism in the Regulation of Daily Rhythms of Body Temperature.
Brain and nerve 2022;74:159-166. DOI:10.11477/mf.1416202001 - Wu Q, Shichino Y, Abe T, Suetsugu T, Omori A, Kiyonari H, Iwasaki S, and Matsuzaki F
Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells.
Nat Commun. 2022;13(1):470. DOI:10.1038/s41467-022-28097-y - Ishiguro K
Sexually dimorphic properties in meiotic chromosome.
Sexual Development 2022:in press. DOI:10.1159/000520682 - Hidekazu Sotoyama, Hiroyoshi Inaba, Yuriko Iwakura, Hisaaki Namba, Nobuyuki Takei, Toshikuni Sasaoka, Hiroyuki Nawa
The dual role of dopamine in the modulation of information processing in the prefrontal cortex underlying social behavior.
The FASEB Journal 2022;36:e22160. DOI:10.1096/fj.202101637R. - Fujita T, Yokoyama T, Shirouzu M, Taguchi H, Ito T, and Iwasaki S
The landscape of translational stall sites in bacteria revealed by monosome and disome profiling.
RNA 2022;28(3):290-302. DOI:10.1261/rna.078188.120 - Hiramatsu Y, Suzuki K, Nishida T, Onoda N, Satoh T, Akira S, Ikawa M, Ikeda H, Kamei J, Derouiche S, Tominaga M, Horiguchi Y
The mechanism of pertussis cough revealed by the mouse-coughing model.
mBio 2022;13:e0319721. DOI:10.1128/mbio.03197-21 - Danjo Y, Shinozaki Y, Natsubori A, Kubota Y, Kashiwagi K, Tanaka KF, Koizumi S.
The Mlc1 promotor directs Müller cell-specific gene expression in the retina.
translational vision science & technology 2022;11:25. DOI:10.1167/tvst.11.1.25 - Morimoto y, Tokumitsu A, . , Shigeki Ohta
TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF).
Neurochem Res 2022:in press. DOI:10.1007/s11064-022-03629-6 - Masai, H.
TT-pocket/HIRAN: binding to 3’-terminus of DNA for recognition and processing of stalled replication forks.
J. Biochem. 2022:in press. DOI:10.1093/jb/mvac042 - Naoto Hori, Yuki Takakura, Ayumi Sugino, Shuto Iwasawa, Kota Nomizo, Naoto Yamaguchi, Hiroyuki Takano, Noritaka Yamaguchi
Vestigial-like family member 3 (VGLL3) stimulates cell motility by inducing High mobility group AT-hook 2 (HMGA2) expression in cancer cells.
Journal of Cellular and Molecular Medicine 2022;26(9):2686-2697. DOI:10.1111/jcmm.17279 - 中村 加枝, 石井 宏憲, 安田 正治
【意思決定と行動選択の神経科学】セロトニンと意思決定.
Clinical Neuroscience 2021;39(8):979-983. - Lauren C Briere, Melissa A Walker, Frances A High, Cynthia Cooper, ..., Masaaki Komatsu (19人中１８番目), David A Sweetser
A description of novel variants and review of phenotypic spectrum in UBA5-related early epileptic encephalopathy.
Cold Spring Harb Mol Case Stud 2021;7:a005827. DOI:10.1101/mcs.a005827 - Jin Lee, Xiaoxi Chen, Yuming Wang, Tatsunori Nishimura, Mengjiao Li, Satoko Ishikawa, Takiko Daikoku, Junya Kawai, Arinobu Tojo, Noriko Gotoh
A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer.
Biochem Biophys Res Commun 2021;584:7-14. DOI:10.1016/j.bbrc.2021.11.001 - Miyanishi H, Nitta A
A role of BDNF in the depression pathogenesis and a potential target as antidepressant: the modulator of stress sensitivity "Shati/Nat8l-BDNF system" in the dorsal striatum.
Pharmaceuticals 2021;14:889. DOI:10.3390/ph14090889 - Kawai, F., Ohkuma, M., Horiguchi, M., Ichinose, H., and Miyachi, E.I.
A subset of cone bipolar cells expresses the Na(+) channel SCN2A in the human retina.
Exp. Eye Res. 2021;202:108299. DOI:10.1016/j.exer.2020.108299 - Kazuhiro Okumura(責任著者), Megumi Saito, Yuichi Wakabayashi
A wild-derived inbred mouse strain, MSM/Ms, provides insights into novel skin tumor susceptibility genes.
Experimental Animals 2021;70(3):272-283. DOI:10.1538/expanim.21-0017 - Fukushima, H., Zhang, Y., Kida, S.*
Active transition of fear memory phase from reconsolidation to extinction through ERK-mediated prevention of reconsolidation.
J. Neurosci. 2021;41:1288-1300. DOI:10.1523/JNEUROSCI.1854-20.2020 - Tanaka, M., Shigetomi, E., Parajuli, B., Nagatomo, H., Lee, JH., Kim, SK., Nabekura, J., Koizumi, S. et al.
Adenosine A2B receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
GLIA 2021;69:2546-2558. DOI:10.1002/glia.24006 - Mizuno M, Khaledian B, Maeda M, Hayashi T, Mizuno S, Kono S, Okada S, Suzuki M, Takao S, Minami H, Asai N, Sugiyama F, Takahashi S, Shimono Y, et al.
Adipsin-Dependent Secretion of Hepatocyte Growth Factor Regulates the Adipocyte-Cancer Stem Cell Interaction.
Cancers 2021;13:e4238. DOI:10.3390/cancers13164238 - Hirai I, Funakoshi T, Kamijuku H., Ohta S, Fujita T, Tanosaki R, Handa M, Okamoto S, Amagai M, Kawakami Y.
Adoptive cell therapy using tumor-infiltrating lymphocytes for melanoma refractory to immune-checkpoint inhibitors.
Cancer Sci 2021;112:3163-3172. DOI:10.1111/cas.15009 - Jingushi K, Aoki M,Kawahara K, Furukawa T, Tsujikawa K et al.
ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer.
Sci Rep 2021;11:8677-8677. DOI:10.1038/s41598-021-87763-1 - Shun Hamada, Masashi Nagase, Tomohiko Yoshizawa, Akari Hagiwara, Yoshikazu Isomura, Ayako M Watabe, Toshihisa Ohtsuka.
An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping.
Communications Biology 2021;4:461. DOI:10.1038/s42003-021-01977-7 - Taichi Sugawara, Kyoko Furuse, Tetsuhisa Otani, Tomohiko Wakayama, Mikio Furuse
Angulin-1 seals tricellular contacts independently of tricellulin and claudins.
Journal of Cell Biology 2021;220:e202005062. DOI:10.1083/jcb.202005062 - Yusuke Murakami, Ryutaro Fukui, Reika Tanaka, Yuji Motoi, Atsuo Kanno, Ryota Sato, Kiyoshi Yamaguchi, Yoichi Furukawa,Naomi Yamashita, Kensuke Miyake
Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes.
Frontiers in Immunology 2021;12:777197. DOI:10.3389/fimmu.2021.777197.eCollection2021 - Shinichi Nakagawa, Tomohiro Yamazaki, Taro Mannen, Tetsuro Hirose
ArcRNAs and the formation of nuclear bodies.
Mammalian Genomes 2021;33:382-401. DOI:10.1007/s00335-021-09881-5 - Bunno, T., Awakawa, T., Mori, T., Abe, I.
Aziridine formation by a Fe(II)/α-ketoglutarate dependent oxygenase and 2-aminoisobutyrate biosynthesis in fungi.
Angew. Chem. Int. Ed. 2021;60:15827-15831. DOI:10.1002/anie.202104644 - Nagata T, Minami K, Yamamoto M, Hiraki T, Idogawa M, Fujimoto K, Kageyama S, Tabata K, Kawahara K, Furukawa T, Sato M et al.
BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma.
Int J Mol Sci. 2021;22:11509. DOI:10.3390/ijms222111509 - Nakajima K, Ishiwata M, Weitemier AZ, Shoji H, Monai H, Miyamoto H, Yamakawa K, Miyakawa T, McHugh TJ, Kato T
Brain-specific heterozygous loss-of-function of ATP2A2, endoplasmic reticulum Ca2+ pump responsible for Darier’s disease, causes behavioral abnormalities and a hyper-dopaminergic state.
Human Molecular Genetics 2021;30:1762-1772. DOI:10.1093/hmg/ddab137 - Komeno M, Pang X, Shimizu A, .., Ogita H.
Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice.
J Biol Chem 2021;296:100761. DOI:10.1016/j.jbc.2021.100761 - Sato A, Rahman NIA, Shimizu A, Ogita H.
Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
Cancer Sci 2021;112:4005-4012. DOI:10.1111/cas.15114 - Mori, T., Abe, I., Toshiya, S., Kobayashi, M. et al.
C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes.
Nature Commun. 2021;12:6294. DOI:10.1038/s41467-021-26585-1 - Masashi Kawami, Shinnosuke Takenaka, Mizuki Akai, Ryoko Yumoto, Mikihisa Takano
Characterization of miR-34a-inudced epithelial-mesenchymal transition in Non-small lung cancer cells focusing on p53.
Biomolecules 2021;11:1853. DOI:10.3390/biom11121853 - Chukai Y, Iwamoto T, Itoh K, Tomita H, Ozaki T
Characterization of mitochondrial calpain-5.
Biochim Biophys Acta Mol Cell Res 2021;1868(5):118989. DOI:10.1016/j.bbamcr.2021.118989 - Yasushi Takemoto, Shin Kadota, Itsunari Minami, Shinya Otsuka, Satoshi Okuda, Masahiro Abo, Louvy Lynn Punzalan, Yan Shen, Yuji Shiba, Motonari Uesugi
Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis.
Angewandte Chemie International Edition 2021;60:21824-21831. DOI:10.1002/anie.202100523 - Seimiya H, Nagasawa K, Shin-Ya K
Chemical targeting of G-quadruplexes in telomeres and beyond for molecular cancer therapeutics.
J Antibiot 2021;74:617-628. DOI:10.1038/s41429-021-00454-x - Haryono A, Ikeda K, Nugroho D, Ogata T, Tsuji Y, Matoba S, Moriwaki K, Kitagawa H, Igarashi M, Hirata K, Emoto N
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 plays a cardioprotective role in heart failure caused by acute pressure overload.
J Am Heart Assoc 2021;11(7):e023401. DOI:10.1161/JAHA.121.023401 - Hou X*, Nozumi M, Nakamura H, Igarashi M, Sugiyama S*
Coactosin Promotes F-actin Protrusion in Growth Cones under Cofilin-related Signaling Pathway.
Front Cell Dev Biol 2021;9:660349. DOI:10.3389/fcell.2021.660349 - Ichihara K, Matsumoto A, Nishida H, Kito Y, Shimizu H, Shichino Y, Iwasaki S, Imami K, Ishihama Y, and Nakayama KI.
Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons.
Nucleic Acids Res 2021:gkab549. DOI:10.1093/nar/gkab549 - Katsuya Uchida and Mao Suzuki
Congenital Hypothyroidism and Brain Development: Association with Other Psychiatric Disorders.
Frontiers in Neuroscience 2021;15:772382. DOI:10.3389/fnins.2021.772382 - Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Motegi SI, Tokunaga F, Ishikawa O.
Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease.
Sci Rep. 2021;11:23146. DOI:10.1038/s41598-021-02522-6 - Miyashita H, Oikawa D, Terawaki S, Kabata D, Shintani A, Tokunaga F.
Crosstalk between NDP52 and LUBAC in innate immune responses, cell death, and xenophagy.
Front Immunol. 2021;12:635475. DOI:10.3389/fimmu.2021.635475 - Simankova A, Bizen N, Saitoh S, Shibata S, Ohno N, Abe M, Sakimura K, Takebayashi H.
Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression.
Glia 2021;69:2559-2574. DOI:10.1002/glia.24058 - Murakami R, Sumiyoshi T, Negishi L, Siomi MC.
DEAD‐box polypeptide 43 facilitates piRNA amplification by actively liberating RNA from Ago3‐piRISC.
EMBO Rep. 2021;22:e51313. DOI:10.15252/embr.202051313 - Naniwa, K. and Aonuma H.
Descending and ascending signals that maintain rhythmic walking pattern in the cricket.
Frontiers in Robotics and AI 2021;8:625094. DOI:10.3389/frobt.2021.625094 - Daikuzono H, Yamazaki M, Sato Y, Takahashi T, Yamagata K
Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes.
Biochem Biophys Res Commun. 2021;578:170-176. DOI:10.1016/j.bbrc.2021.08.054 - Kogaki T, Ohshio I,Kawahara K, Furukawa T, Jingushi K, Tsujikawa K et al.
Development of a highly sensitive method for the quantitative analysis of modified nucleosides using UHPLC-UniSpray-MS/MS.
J Pharm Biomed Anal 2021;197:113943-113943. DOI:10.1016/j.jpba.2021.113943 - Watanabe Y, Sugano E, Tabata K, Hatakeyama A, Sakajiri T, Fukuda T, Ozaki T, Suzuki T, Sayama T, Tomita H
Development of an optogenetic gene sensitive to daylight and its implications in vision restoration.
npj Regenerative Medicine 2021;6(1):64. DOI:10.1038/s41536-021-00177-5 - Tsuji, R., Inoue, H., Uehara, M., Kida, S.*
Dietary magnesium deficiency induces the expression of neuroinflammation-related genes in mouse brain.
Neuropsychopharmacol Rep. 2021;41:230-236. DOI:10.1002/npr2.12167 - Irie, T., Asami, T., Sawa, A., Uno, Y., Taniyama, C., Funakoshi, Y., Masai, H., Sawa, M.
Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers.
J. Med. Chem. 2021;64:14153-14164. DOI:10.1021/acs.jmedchem.1c01319 - Yuta Arai, Hiroki Oguri*
Divergent synthesis of functionalized dihydropyridines and pyrroles via metal-free one-pot domino reactions of a gem-disubstituted propargyl amine and an alkynyl sulfone.
Tetrahedron Lett. 2021 2021;78:153283. DOI:10.1246/cl.200920 - Toyokuni S, Kong Y, Zheng H, Mi D, Katabuchi M, Motooka Y, Ito F.
Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles.
J Cancer Prev 26: 244-249, 2021 2021;26:244-249. DOI:10.15430/JCP.2021.26.4.244 - Uchida M, Noda Y, Hasegawa S, Hida H, Taniguchi M, Mouri A, Yoshimi A, Nabeshima T, Yamada K, Aida T, Tanaka K, Ozaki N.
Early postnatal inhibition of GLAST causes abnormalities of psychobehaviors and neuronal morphology in adult mice.
Neurochem Int. 2021;150:105177. DOI:10.1016/j.neuint.2021.105177 - Kashiwagi K, Shichino Y, Osaki T, Sakamoto A, Nishimoto M, Takahashi M, Mito M, Weber F, Ikeuchi Y, Iwasaki S, and Ito T
eIF2B-capturing viral protein NSs suppresses the integrated stress response.
Nat Commun. 2021;12(1):7102. DOI:10.1038/s41467-021-27337-x - Yang, P., Tian, H., Zou, Y.R., Chambon, P., Ichinose, H., Honig, G., Diamond, B., and Kim, S.J.
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Front Immunol 2021;12:616583. DOI:10.3389/fimmu.2021.616583 - Kitakaze, M., Chijimatsu, R., Vecchione, A., Kitagawa, T., Doki, Y., Eguchi, H., Ishii, H.
Epithelial cell transformation and senescence as indicators of genome aging: current advances and unanswered questions.
Int. J. Mol. Sci. 2021;22:7544. DOI:10.3390/ijms22147544 - Naho Nomura, Chiaki Ito, Takako Ooshio1, .., Masaaki Komatsu(15人中13番目), ToruYanagawa, Atsushi Hirao
Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner.
Scientific Reports 2021;11:1666. DOI:10.1038/s41598-021-81076-z - Yusuke Hanaki, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita
Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions.
Fundamental Toxicological Sciences 2021;8(3):69-73. DOI:10.2131/fts.8.69 - Shepherd S., Jackson C.W., Sharkh S.M., Aonuma H., Oliveira E.E. and Newland P.L.
Extremely low-frequency electromagnetic fields entrain locust wingbeats.
Bioelectromagnetics 2021;42:296-308. DOI:10.1002/bem.22336 - Ishizaki Y., Higuchi T., Yanagimoto Y., Kobayashi H., Noritake A., Nakamura K., Kaneko K.
Eye gaze differences in school scenes between preschool children and adolescents with high-functioning autism spectrum disorder and those with typical development.
BioPsychoSocial medicine 2021;15(1):2-2. DOI:10.1186/s13030-020-00203-w - Grigor Varuzhanyan, Mark S Ladinsky, Shun-Ichi Yamashita, Manabu Abe, Kenji Sakimura, Tomotake Kanki, David C Chan
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.
Development 2021;148:dev199686. DOI:10.1242/dev.199686 - Hoshino C, Konno A, Hosoi N, Kaneko R, Mukai R, Nakai J, Hirai H.
GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter.
Mol Brain. 2021;14:33. DOI:10.1186/s13041-021-00746-1 - Abe M., Cox T.C., Firulli A.B., Kanai S.M., Dalhka J., Lim K-C., Engel D.J., Clouthier D.E.
Gata3 is essential for separating patterning domains during facial morphogenesis.
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Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.
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Identification of a small-molecule glucose transporter inhibitor, glutipyran, that inhibits cancer cell growth.
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Frontiers in Molecular Biosciences 2021;8 DOI:10.3389/fmolb.2021.738829 - Munirah I, Ozaki T, Sekine A, Morimoto M, Sugawara M, Takada H, Sugano E, Tomita H, Kiyono T, Fukuda T
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Immunomodulation by Inflammation during Liver and Gastrointestinal Tumorigenesis and Aging.
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Improvement of short straws for sperm cryopreservation: installing an air-permeable filter facilitates handling.
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Interactions between the amygdala and medial prefrontal cortex as upstream regulators of the hippocampus to reconsolidate and enhance retrieved inhibitory avoidance memory.
Mol Brain 2021;14(1):44. DOI:10.1186/s13041-021-00753-2 - Shimizu K, Gi M, Suzuki S, North BJ, Watahiki A, Fukumoto S, Asara JM, Tokunaga F, Wei W, Inuzuka H.
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Interstitial axon collaterals of callosal neurons form association projections from the primary somatosensory to motor cortex in mice.
Cereb. Cortex 2021;31:5225-5238. DOI:10.1093/cercor/bhab153 - Itoh Y., Itoh S., Naruse H., Kagioka T., Abe M., Hayashi M.
Intracellular density is a novel indicator of different stages of murine osteoblast lineage cells.
Journal of Cellular Biochemistry 2021;122(12):1805-1816. DOI:10.1002/jcb.30135 - Ito T, Hiramatsu Y, Mouri A, Yoshigai T, Takahashi A, Yoshimi A, Mamiya T, Ozaki N, Noda Y.
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Neurosci Res 2021;171:83-91. DOI:10.1016/j.neures.2021.01.002 - Mori Y, Mouri A, Kunisawa K, Hirakawa M, Kubota H, Kosuge A, Niijima M, Hasegawa M, Kurahashi H, Murakami R, Hoshi M, Nakano T, Nabeshima T, Saito K.
Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid.
Behav Brain Res 2021;405:113191. DOI:10.1016/j.bbr.2021.113191 - Owaki D., Aonuma H., Sugimoto Y. and Ishiguro A.
Leg amputation modifies coordinated activation ofthe middle leg muscles in the cricket Gryllus bimaculatus.
Scientific Reports 2021;11:1327. DOI:10.1038/s41598-020-79319-6 - Penisson M, Jin M, Wang S, Hirotsune S, Francis F, Belvindrah R.
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Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion.
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Loss of P2Y1 receptor triggers glaucoma-like pathology in mice.
British Journal of Pharmacology 2021;178:4552-4571. DOI:10.1111/bph.15637 - Nishida R, Kawaguchi Y, Matsubayashi J, Ishikawa R, Kida S, Takei K.
LOTUS, an endogenous Nogo receptor antagonist, is involved in synapse and memory formation.
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Manganese Dynamics in Mouse Brain After Systemic MnCl2 Administration for Activation-Induced Manganese-Enhanced MRI.
Frontiers in Neural Circuits 2021;15:787692. DOI:10.3389/fncir.2021.787692 - Ishiguro K, Shimada R.
MEIOSIN directs initiation of meiosis and subsequent meiotic prophase programs during spermatogenesis.
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Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis.
Nat Struct Mol Biol 2021;28:583-593. DOI:10.1038/s41594-021-00614-5 - Tomofumi Watanabe, Kazuhiro Sakamoto
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Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient.
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MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function.
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Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment.
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/ mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes.
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Multiple nicotinic acetylcholine receptor subtypes regulate social or cognitive behaviors in mice repeatedly administered phencyclidine.
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Mutual selfish manipulation enhances mutualism in an aphid-ant symbiosis.
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Mutually repulsive EphA7-EfnA5 organize region-to-region corticopontine projection by inhibiting collateral extension.
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Neurexins in serotonergic neurons regulate serotonin release and complex mouse behaviors.
bioRxiv 2021:in press. DOI:10.1101/2021.12.09.471904 - Atsushi Chiba, Kazunori Morita, Ken‑ichi Oshio, Masahiko Inase
Neuronal activity in the monkey prefrontal cortex during a durationdiscrimination task with visual and auditory cues.
Scientific Reports 2021;11:17520. DOI:10.1038/s41598-021-97094-w - Mashima T, Wakatsuki T, Kawata N, Jang MK, Nagamori A, Yoshida H, Nakamura K, Migita T, Seimiya H, Yamaguchi K
Neutralization of the induced VEGF-A potentiates the therapeutic effect of an anti-VEGFR2 antibody on gastric cancer in vivo.
Sci Rep 2021;11:15125. DOI:10.1038/s41598-021-94584-9 - Izuo N, Nitta A
New Insights regarding diagnosis and medication for schizophrenia based on neuronal synapse-microglia interaction.
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Nicotine enhances firing activity of layer 5 pyramidal neurons in the medial prefrontal cortex through inhibition of Kv7 channels.
Biological and Pharmaceutical Bulletin 2021;44:724-731. DOI:10.1248/bpb.b21-00137 - Esaki H, Izumi S, Fukao A, Nishitani N, Deyama S, Kaneda K
Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice.
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Nicotine enhances object recognition memory via stimulating α4β2 and α7 nicotinic acetylcholine receptors in the medial prefrontal cortex of mice.
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One polyketide synthase, two distinct products: trans-acting enzyme-controlled product divergence in calbistrin biosynthesis.
Angew. Chem. Int. Ed. 2021;60:8851-8858. DOI:10.1002/anie.202016525 - Yusuke Hanaki, Yusuke Araki, Toshio Nishikawa, Ryo C. Yanagita
Oscillatoxin E and its C7 epimer show distinct growth inhibition profiles against several cancer cell lines.
Heterocycles 2021;102:2353-2362. DOI:10.3987/COM-21-14538 - Eskelinen EL, Kageyama S, Komatsu M
p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control.
Mol Cell Oncol 2021;8:1890990. DOI:10.1080/23723556.2021.1890990 - Shun Kageyama, Sigurdur Runar Gudmundsson, .. Satoshi Waguri, Eeva-Liisa Eskelinen, Masaaki Komatsu
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.
Nature Communications 2021;12:1-16. DOI:10.1038/s41467-020-20185-1 - Miyata K, Imai Y, Hori S, Toyokuni S, Sakata T, Shirahige K, Kojima R, Nakayama M, Oshima M, Nagayama S, Seimiya H, Hirota T, Saya H, Hara E, Takahashi A et al.
Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
Proc Natl Acad Sci U S A 2021;118:e2025647118. DOI:10.1073/pnas.2025647118 - Wulaer B, Kunisawa K, Tanabe M, Yanagawa A, Saito K, Mouri A, Nabeshima T.
Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice.
Mol Brain. 2021;14:43. DOI:10.1186/s13041-021-00760-3 - Tabata K, Sugano E, Hatakeyama A, Watanabe Y, Suzuki T, Ozaki T, Fukuda T, Tomita H
Phototoxicities Caused by Continuous Light Exposure Were Not Induced in Retinal Ganglion Cells Transduced by an Optogenetic Gene.
Int J Mol Sci 2021;22(13):6732. DOI:10.3390/ijms22136732 - Kawasaki A, Sakai A, Nakanishi H, Hasegawa J, Taguchi T, Sasaki J, Arai H, Sasaki T, Igarashi M, *Nakatsu F
PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission.
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PKCδ deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCδ knockout mice.
PLOS ONE 2021;16(7):e0253912. DOI:10.1371/journal.pone.0253912 - Yuko Nagamura, Makoto Miyazaki, Yoshiko Nagano, Masako Yuki, Kiyoko Fukami, Kazuyoshi Yanagihara, Kazuki Sasaki, Ryuichi Sakai, and Hideki Yamaguchi
PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification.
Oncogenesis 2021;10:25. DOI:10.1038/s41389-021-00314-1 - Ohi K, Nishizawa D, Sugiyama S, Takai K, Kuramitsu A, Hasegawa J, Soda M, Kitaichi K, Hashimoto R, Ikeda K, Shioiri T.
Polygenic Risk Scores Differentiating Schizophrenia From Bipolar Disorder Are Associated With Premorbid Intelligence in Schizophrenia Patients and Healthy Subjects.
Int J Neuropsychopharmacol 2021;24(7):562-569. DOI:10.1093/ijnp/pyab014 - Scibelli A.E., Caron D.P, Aonuma H., Trimmer B.A.
Proleg retractor muscles in Manduca sexta larvae are segmentally different suggesting anteroposterior specialization.
Journal of Experimental Biology 2021;224:jeb242508. DOI:10.1242/jeb.242508 - Muroi M, Osada H.
Proteomics-based target identification of natural products affecting cancer metabolism.
J Antibiot 2021;74:639-650. DOI:10.1038/s41429-021-00437-y - Ono R.*, Abe M.*, Koike N., Inokawa H., Tuchiya Y., Umemura Y., Sasawaki Y., Yamamoto T., Wakisaka S., Kanamura N., Yagita K.
Quantitative morphometric analysis of molar teeth and alveolar bone in aged mice using micro-computed tomography.
Journal of Oral Bioscience 2021;63(3):265-270. DOI:10.1016/j.job.2021.07.006 - Shinsuke Fujii, Takuma Ishibashi, Megumi Kokura, Tatsufumi Fujimoto, Shinji Matsumoto, ..Tamotsu Kiyoshima
RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation.
The Journal of pathology 2021;256:119-133. DOI:10.1002/path.5814 - Takahashi H, Asahina R, Fujioka M, Matsui TK, Kato S, Mori E, Hioki H, Yamamoto T, Kobayashi K, Tsuboi A
Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
Proc. Natl. Acad. Sci. USA. 2021;118:e2018850118. DOI:10.1073/pnas.2018850118 - Ryo Ninokata, Riho Korogi, Junya Nakao, Tsutomu Fukuda, Gen Onodera, Masanari Kimura
Reconstruction of Carbon Bond Frameworks via Oxapalladacycle Promoted by Synergistic Effect of Palladium Catalyst and Triethylborane.
Synthesis 2021;53:3110-3120. DOI:10.1055/a-1485-5781 - Oki M, Masai H.
Regulation of HP1 protein by phosphorylation during transcriptional repression and cell cycle.
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Regulation of neutrophil functions by Hv1/VSOP voltage-gated proton channels.
International Journal of Molecular Sciences 2021;22:2620. DOI:10.3390/ijms22052620 - Kaori Oka（研究代表者、共第一著者）, Shusuke Fujioka（共第一著者）, Yoshimi Kawamura（共第一著者）, Kimi Araki（研究協力者）Kyoko Miura（責任著者） et al.
Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats.
bioRxiv 2021:in press. DOI:10.1101/2021.10.21.465383 - Iwakawa HO, Lam YWA, Mine A, Fujita T, Kiyokawa K, Yoshikawa M, Takeda A, Iwasaki S, and Tomari Y.
Ribosome stalling caused by the Argonaute-miRNA-SGS3 complex regulates production of secondary siRNA biogenesis in plants.
Cell Rep 2021;35:109300. DOI:10.1016/j.celrep.2021.109300 - Toyokuni S, Ito F, Motooka Y
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Metallomics Res 2021;1:#MR202102. - Hsiao H-W, Yang C-C, Masai H
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Genome Instability & Disease 2021;2:263-280. DOI:10.1007/s42764-021-00049-8 - 2） Asai, A., Konno, M., Ozaki, M., Kawamoto, K., Chijimatsu, R., Kondo, N., Hirotsu, T., Ishii, H.
Scent test using caenorhabditis elegans to screen for earlystage pancreatic cancer.
Oncotarget 2021;12:1687-1696. DOI:10.18632/oncotarget.28035 - Nitta A, Izuo N, Hamatani K, Inagaki R, Kusui Y, Fu K, Asano T, Torii Y, Habuchi C, Sekiguchi H, Iritani S, Muramatsu SI, Ozaki N, Miyamoto Y.
Schizophrenia-like behavioraliImpairments in mice with suppressed expression of Piccolo in the medial prefrontal cortex.
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Senescence-accelerated mouse prone 8 (SAMP8) mice exhibit reduced entoconid in the lower second molar.
Archives of Oral Biology 2021;128:105172. DOI:10.1016/j.archoralbio.2021.105172 - Kimura Y, Izumiya Y, Araki S, Yamamura S, Hanatani S, Onoue Y, Ishida T, Arima Y, Nakamura T, Bober E, Braun T, Kaikita K, Yamagata K, Tsujita K
Sirt7 deficiency attenuates neointimal formation following vascular injury by modulating vascular smooth muscle cells proliferation.
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SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARg2.
J Diabetes Investig 2021;12(10):1765-1774. DOI:10.1111/jdi.13567 - Kaiwen Liu, Ryota Sato, Takuma Shibata, Ryosuke Hiranuma, Tatjana Reuter, Takeshi Ichinohe, Manabu Ozawa, Nobuaki Yoshida, Eicke Latz, Kensuke Miyake
Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.
International Immunology 2021;33(9):479-490. DOI:10.1093/intimm/dxab033 - Yoshimoto R, Chhipi Shrestha JK, .. Iwasaki S, and Yoshida M
Spliceostatin A interaction with SF3B1 limits U1 snRNP availability and causes premature cleavage and polyadenylation.
Cell Chem Biol 2021;28:1356-1365. DOI:10.1016/j.chembiol.2021.03.002 - Chhipi Shrestha JK, Schneider-Poetsch T, Suzuki T, Mito M, Khan K, Dohmae N, Iwasaki S, and Yoshida M
Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns.
Cell Chem Biol. 2021;29(2):259-275. DOI:10.1016/j.chembiol.2021.07.015 - Ryo Ishikawa, Mizuho Yasuda, Shogo Sasaki, Yue Ma, Kazuo Nagasawa, Masayuki Tera
Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease.
Chem. Commun., 2021;57:7236-7239. DOI:10.1039/D1CC03294A - Shimo, S., Ushimaru, R., Engelbrecht, A., Harada, M., Miyamoto, K., Andreas, K., Uchiyama, M., Kaysser, L., Abe, I.
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J. Am. Chem. Soc. 2021;143:18413-18418. DOI:10.1021/jacs.1c10201 - Miyanishi H, Muramatsu SI, Nitta A
Striatal Shati/Nat8l-BDNF pathways determine the sensitivity to social defeat stress in mice through epigenetic regulation.
Neuropsychopharmacology 2021;14:1594-1605. DOI:10.1038/s41386-021-01033-2 - Yang, J., Mori, T., Wei, X., Matsuda, Y., Abe, I.
Structural basis for isomerization reactions in fungal tetrahydroxanthone biosynthesis and diversification.
Angew. Chem. Int. Ed. 2021;60:19458-19465. DOI:10.1002/anie.202107884 - Shepherd S., Lima M.A.P., Oliveira E.E., Sharkh S.M., Aonuma H., Jackson C.W., and Newland P.L.
Sublethal neonicotinoid exposure attenuates the effects of electromagnetic fields on honey bee flight and learning.
Environmental Advances 2021;4:100051. DOI:10.1016/j.envadv.2021.100051 - Hiroki Oguri*
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Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice.
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The contribution of low contrast–preferring neurons to information representation in the primary visual cortex after learning.
Science Advances 2021;7(48):eabj9976. DOI:10.1126/sciadv.abj9976 - Kimura H, Sada R, Takada N, Harada A, Doki Y, Eguchi H, Yamamoto H, Kikuchi A
The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancer.
Oncogene 2021;40:4486-4502. DOI:10.1038/s41388-021-01860-z - Hori, H., Itoh, M., Matsui, M., Kamo, T., Saito, T., Nishimatsu, Y, Kito, S., Kida, S., Kim, Y.
The efficacy of memantine in the treatment of civilian posttraumatic stress disorder: an open label trial.
European Journal of Psychotraumatology 2021;12:1:1859821. DOI:10.1080/20008198.2020.1859821 - Nakayama Jun, Han Yuxuan, Kuroiwa Yuka, Azuma Kazushi, Yamamoto Yusuke, Semba Kentaro,
The In Vivo Selection Method in Breast Cancer Metastasis.
International Journal of Molecular Sciences 2021;22:1886. DOI:10.3390/ijms22041886 - Kazuhiro Okumura(第一著者), Megumi Saito, Eriko Isogai, and Yuichi Wakabayashi(責任著者)
The Japanese Wild-Derived Inbred Mouse Strain, MSM/Ms in Cancer Research.
Cancers (Basel). 2021;13(5):1026. DOI:10.3390/cancers13051026 - Michio Sato, .. Kumiko Yoshinobu, Mai Imasaka, Masatake Araki, .. Kimi Araki, Yuichi Oike
The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis.
Nat Commun 2021;12:2529. DOI:10.1038/s41467-021-22735-7 - Takeuchi Y, Kimura N, Murayama T, et al, Gotoh N
The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis.
Proc. Natl, Acad, Sci, USA 2021;vol.118:e2103658118. DOI:10.1073/pnas.2103658118 - Ryo Yoshikawa, Koichiro Abe
The multi-kinase inhibitor dasatinib suppresses autoinflammation and increases bone density in a mouse model for chronic recurrent multifocal osteomyelitis.
Cell Biochem Funct. 2021;39:521-527. DOI:10.1002/cbf.3617 - Mariko Ito, Masashi Nagase, Suguru Tohyama, Kaori Mikami, Fusao Kato, Ayako M Watabe.
The parabrachial-to-amygdala pathway provides aversive information to induce avoidance behavior in mice.
Molecular Brain 2021;14:94. DOI:10.1186/s13041-021-00807-5 - Nishio N, Hayashi K, Ishikawa AW, Yoshimura Y
The role of early visual experience in the development of spatial-frequency preference in the primary visual cortex.
The Journal of Physiology 2021;599(17):4131-4152. DOI:10.1113/JP281463 - Furuya K, Wu T, Orimoto A, Sugano E, Tomita H, Kiyono T, Kurose T, Takai Y, Fukuda T
The transcriptome of wild-type and immortalized corneal epithelial cells.
Sci Data 2021;8(1):126. DOI:10.1038/s41597-021-00908-9 - Shimatani H, Inoue Y, Maekawa Y, Miyake T, Yamaguchi Y, and Doi M
Thermographic imaging of mouse across circadian time reveals body surface temperature elevation associated with non-locomotor body movements.
PLoS One 2021;16:e0252447. DOI:10.1371/journal.pone.0252447 - Miyahara H, Natsumeda M, Kanemura Y, Yamasaki K, Yoshimura J, Fujii Y, Suenobu S, Ihara K, Hara J, Kakita A, Yoshida M, Iwasaki Y
Topoisomerase IIβ immunoreactivity (IR) co-localizes with neuronal marker-IR but not glial fibrillary acidic protein-IR in GLI3-positive medulloblastomas: an immunohistochemical analysis of 124 medulloblastomas from the Japan Children's Cancer Group.
Brain Tumor Pathol 2021;49(3):527-534. DOI:10.1007/s10014-021-00396-0 - Hiroyuki Saiga, Masaki Ueno, Takashi Tanaka, Tsuneyasu Kaisho, Katsuaki Hoshino
Transcription factor MafB-mediated inhibition of type I interferons in plasmacytoid dendritic cells.
International Immunology 2021:dxab103. DOI:10.1093/intimm/dxab103 - Doi M, Oka Y, Taniguchi M, Sato M.
Transient expansion of the expression region of Hsd11b1, encoding 11β-hydroxysteroid dehydrogenase type 1, in the developing mouse neocortex.
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Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through αB-crystallin intracellular dynamics.
J Biochem 2021;170(5):577-585. DOI:10.1093/jb/mvab066 - Takahashi, S., Fukushima, H., Yu, Z., Tomita, H., Kida, S.*
Tumor necrosis factor α negatively regulates the retrieval and reconsolidation of hippocampus-dependent memory.
Brain, Behavior, and Immunity 2021;94:79-88. DOI:10.1016/j.bbi.2021.02.033 - Iori Ohmori, Mamoru Ouchida, Hirohiko Imai, Saeko Ishida, Shinya Toyokuni, Tomoji Mashimo
Txn1 mutation causes epilepsy associated with vacuolar degeneration in the midbrain.
bioRxiv 2021:in press. DOI:10.1101/2021.10.07.463470 - Inukai, S., Hara, S., and Ichinose, H.
Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue.
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Vasopressin escape and memory impairment in a model of chronic syndrome of inappropriate secretion of antidiuretic hormone in mice.
Endocrine Journal 2021;68:31-43. DOI:10.1507/endocrj.EJ20-0289 - Yuki Takakura, Naoto Hori, Natsumi Terada, Moeka Machida, Naoto Yamaguchi, Hiroyuki Takano, Noritaka Yamaguchi
VGLL3 activates inflammatory responses by inducing interleukin-1α secretion.
FASEB Journal 2021;11:e21996. DOI:10.1096/fj.202100679RR - Yue Ma, Yuki Wakabayashi, Naruyuki Watatani, Ryota Saito, Takatsugu Hirokawa, Masayuki Tera, Kazuo Nagasawa
Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand.
Org. Biomol. Chem 2021;19(37):8035-8040. DOI:10.1039/D1OB01500A - Nakamura E., Hata K., Takahata Y., Kurosaka H., Abe M., et al
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β-NAD as a Building Block in Natural Product Biosynthesis.
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高脂肪食摂取加齢マウスにおける亜鉛の長期間過剰投与が学習・記憶能に及ぼす影響.
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上皮管腔形態形成の分子機構とその異常による腫瘍形成.
Journal of Japanese Biochemical Society 2021;93:733-748. DOI:10.14952/SEIKAGAKU.2021.930733 - 福田茉由, 向井淳
統合失調症の認知機能障害を改善するエピゲノム治療薬の開発.
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胚盤胞補完法とES細胞を用いた甲状腺再生.
日本再生医療学会総会(Web) 2021;20:ROMBUNNO.P-01-03. - 西條康夫、周啓亮、冉慶松、北原哲彦、小田佳奈子、泰江章博、笹岡俊邦、叶許緑、阿部学、崎村建司、土田正則、味岡洋一
胚盤胞補完法を用いた多能性幹細胞由来肺の作出.
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Application of Optogenetics for Muscle Cells and Stem Cells.
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Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation.
The Journal of Immunology 206:2021, 366-375. DOI:10.4049/jimmunol.2000971 - Ishida A, Igarashi K, Ruike Y, Ishiwata K, Naito K, Kono S, Deguchi H, Fujimoto M, Shiga A, Suzuki S, Yoshida T, Tanaka T, Tatsuno I, Yokote K, Koide H.
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Behavioral consequences of a combination of Gad1 haplodeficiency and adolescent exposure to NMDA receptor antagonist in Long-Evans rat.
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Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.
Nature Communications 12(1):2021, 1848. DOI:10.1038/s41467-021-22059-6 - Adhikara IM, Yagi K, Mayasari DS, Suzuki Y, Ikeda K, Ryanto GRT, Sasaki N, Rikitake Y, Nadanaka S, Kitagawa H, Miyata O, Igarashi M, Hirata K, Emoto N
Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
Arterioscler Thromb Vasc Biol 41(3):2021, 1076-1091. DOI:10.1161/ATVBAHA.120.315789 - Fumito Ishibashi, Tsutomu Fukuda, Shijiao Zha, Aya Hashirano, Shotaro Hirao, Masatomo Iwao
Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin.
Bioscience, Biotechnology, and Biochemistry 85:2021, 181-191. DOI:10.1093/bbb/zbaa028 - Sasaki T, Takei Y.
Constitutive increase of IL-17A in serum affects microglial activity in the hippocampal dentate gyrus.
Jap J Biol Psych. 32(2):2021, in press. - Shimizu T, Takahashi N, Huber VJ, Asawa Y, Ueda H, Yoshimori A, Muramatsu Y, Seimiya H, Kouji H, Nakamura H, Oguri H.
Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α.
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Development of a label-free ATP image sensor for analyzing spatiotemporal patterns of ATP release from biological tissues.
Sensors and Actuators B: Chemical 335:2021, 129686. DOI:10.1016/j.snb.2021.129686 - Suzuki T, Ogita H, Sato A, Minamidate N, Hachiro K.
Differences between atherosclerotic and non-atherosclerotic patients in expression levels of inflammatory mediators in the adipose tissue around the coronary artery.
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Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis.
Exp Hematol 96:2021, 52-62. DOI:10.1016/j.exphem.2021.02.003 - Tsutomu Fukuda, Seiya Okutani, Mayu Sumi, Kazuhito Miyagi, Gen Onodera, Masanari Kimura
Divergent Total Synthesis of Azalamellarins D and N.
Heterocycles 103:2021, in press. DOI:10.3987/COM-20-S(K)53 - Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K.
Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons.
Biomedicines 9 (1):2021, E49. DOI:10.3390/biomedicines9010049 - Ito, N., Riyadh, M., Ahmad, S., Hattori, S., Miyakawa, T. and Ohta, K. et al.
Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice.
Science Translational Medicine 13(587):2021, eaay7896. DOI:10.1126/scitranslmed.aay7896 - Sasaki T, Nagata R, Takahashi S, Takei Y
Effects of RORγt overexpression on the murine central nervous system.
Neuropsychopharmacology Reports -:2021, 1-9. DOI:10.1111/NPR2.12162 - Hikmawan Wahyu Sulistomo, Takayuki Nemoto, Yohko Kage, Hajime Fujii, Taku Uchida, Kogo Takamiya, Hideki Sumimoto, Hiroaki Kataoka, Haruhiko Bito, Ryu Takeya
Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.
Cerebral Cortex -:2021, in press. DOI:10.1093/cercor/bhaa355 - Fujihara K, Sato T, Miyasaka Y, Mashimo T, Yanagawa Y.
Genetic deletion of the 67-kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats.
FEBS Open Bio. -:2021, in press. DOI:10.1002/2211-5463.13065 - Sumitani M, Nishizawa D, Hozumi J, Ikeda K.
Genetic implications in quality palliative care and preventing opioid crisis in cancer-related pain management.
Journal of Neuroscience Research -:2021, in press. DOI:10.1002/jnr.24756 - Natsumeda M, Miyahara H, Yoshimura J, Okada M, Hirato J, Wataya T, Tateishi K, Rodriguez FJ, Suva ML, Taylor MD, Eberhart CG, Fujii Y, Kakita A
GLI3 is associated with neuronal differentiation in SHH-activated and WNT-activated medulloblastoma.
Journal of Neuropathology and Experimental Neurology 80(2):2021, 129-136. DOI:10.1093/jnen/nlaa141 - Miyata S, Kakizaki T, Fujihara K, Obinata H, Hirano T, Nakai J, Tanaka M, Itohara S, Watanabe M, Tanaka KF, Abe M, Sakimura K, Yanagawa Y.
Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice.
Mol Brain. 14:2021, 5. DOI:10.1186/s13041-020-00713-2 - Matsumoto K, Okamoto K, Okabe S, Fujii R, Ueda K, Ohashi K, Seimiya H.
G-quadruplex-forming nucleic acids interact with SF3B2 and suppress innate immune gene expression.
Genes Cells 26:2021, 65-82. DOI:10.1111/gtc.12824 - Dat NQ, Oikawa D, Yoishizato K, Tokunaga F, Pinzani M, Kawada M, et al.
His-Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
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ICAM1-Negative Intravascular Large B-Cell Lymphoma of the Pituitary Gland: A Case Report and Literature Review.
AACE Clinical Case Reports -:2021, in press. DOI:10.1016/j.aace.2021.01.011 - Aoki H, Abe C, Hara A, Miyazaki T, Morita H, Kunisada T.
Induced genetic ablation of Rest leads to the alteration of stimulus-induced response of the vagal nerve.
Genes Cells. 26(2):2021, 45-55. DOI:10.1111/gtc.12819 - Toshinori Matsuoka, Miwako Yamasaki, Manabu Abe, Yukiko Matsuda, Hiroyuki Morino, Hideshi Kawakami, Kenji Sakimura, Masahiko Watanabe, Kouichi Hashimoto
Kv11 (ether-à-go-go-related gene) voltage-dependent K+ channels promote resonance and oscillation of subthreshold membrane potentials.
Journal of Physiology (London) 599:2021, 547-569. DOI:10.1113/JP280342 - Nishiya N, Oku Y, Ishikawa C, Fukuda T, Dan S, Mashima T, Ushijima M, Matsuura M, Tomida A, Seimiya H, Yamori T, Iwao M, Uehara Y et al.
Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor.
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MEK inhibition preferentially suppresses anchorage‐independent growth in osteosarcoma cells and decreases tumors in vivo.
Journal of Orthopaedic Research -:2021, in press. DOI:10.1002/jor.25023 - Asada-Utsugi M, Uemura K, Noda Y, 他8名, Takahashi R, Hattori S, Miyakawa T, Ageta-Ishihara N, Kobayashi K, Kinoshita M, Kinoshita A.
Mice with a cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial memory tasks.
Molecular Brain 14(1):2021, 23. DOI:10.1186/s13041-021-00738-1 - Tesshu Hori, Shohei Ikuta, Satoko Hattori, Keizo Takao, Tsuyoshi Miyakawa, Chieko Koike
Mice with mutations in Trpm1, a gene within the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior.
Molecular Brain 14(1):2021, 61. DOI:10.1186/s13041-021-00749-y - Mushiake H, Ohshiro T, Osawa SI, Hosaka R, Katayama N, Tanaka T, Yawo H, Osanai M.
Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits.
Adv Exp Med Biol. 1293:2021, 501-509. DOI:10.1007/978-981-15-8763-4_34 - Arima Y, Nakagawa Y, Takeo T, Ishida T, Yamada T, Hino S, Yamagata K, Nakamura T, Nakagata N, Tsujita K
Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.
Nature Metabolism 3:2021, 196-210. DOI:10.1038/s42255-021-00342-6 - Aki Takahashi, Hossein Aleyasin, Tetsuya Sasaki, Sonoko Ogawa, Bruce S. McEwen and Scott J. Russo et al
Neuromodulatory effect of interleukin 1 in the dorsal raphe nucleus on individual differences in aggression.
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Neuronal degeneration and cognitive impairment can be prevented via the normalization of mitochondrial dynamics.
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Ni-catalyzed direct carboxylation of propargylic alcohols with carbon dioxide.
Chemistry Letters -:2021, in press. DOI:10.1246/cl.210008 - Ying Luo, Bun Chan, Tsutomu Fukuda, Gen Onodera, Masanari Kimura
Nickel-Catalyzed Carboxylation of Conjugated Dienes with Carbon Dioxide and DIBAL-H for the Synthesis of β,γ-Unsaturated Carboxylic Acids.
Synlett -:2021, in press. DOI:10.1055/a-1336-8034 - Mori T, Kido A, Kawahara I, Nukaga S, Miyagawa Y, Goto K, Mori S, Kishi S, Fujii K, Fujiwara-Tani R, Kuniyasu H
Nutritional intervention for cancer sarcopenia.
Ann Muscloskeletal Med 5(1):2021, 001-004. DOI:10.17352/amm.000024 - Akira C Saito, Tomohito Higashi, Yugo Fukazawa, Tetsuhisa Otani, Masashi Tauchi, Atsuko Y Higashi, Mikio Furuse, Hideki Chiba
Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function.
Molecular biology of the cell -:2021, in press. DOI:10.1091/mbc.E20-07-0464 - Ando S, Fukamachi K, Yoshimoto E, Matsumoto H, Iinuma M and Suzui M.
Palmitoyl piperidinopiperidine, a novel derivative of 10-hydroxy-2-decenoic acid, as a potent and selective anticancer agent against human colon carcinoma cell lines.
Int J Oncol 58:2021, 251-265. DOI:10.3892/ijo.2020.5160 - Okada M, Kawagoe Y, Sato Y, Nozumi M, Ishikawa Y, Tamada A, Yamazaki H, Sekino Y, Kanemura Y, Shinmyo Y, Kawasaki H, Kaneko N, Sawamoto K, Fujii Y, Igarashi M
Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates.
Mol Brain 14(1):2021, 66. DOI:10.1186/s13041-021-00755-0 - Hayashi T
Post-translational palmitoylation of ionotropic glutamate receptors in excitatory synaptic functions.
British Journal of Pharmacology 178:2021, 784-797. DOI:10.1111/bph.15050 - Shinozaki Y, Koizumi S
Potential role of astrocytes and Muller cells in the pathogenesis of glaucoma.
Journal of Pharmacological Sciences 145:2021, 262-267. DOI:10.1016/j.jphs.2020.12.009 - H. Igata, Y. Ikegaya, T. Sasaki
Prioritized experience replays on a hippocampal predictive map for learning.
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A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities.
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Human Genetics 140(2):2020, 277-287. DOI:10.1007/s00439-020-02198-4 - Noriho Shinagawa, Kentaro Minami, Takayuki Ishida, Hiroshi Hijioka, Masatatsu Yamamoto, Kohichi Kawahara, Tatsuhiko Furukawa, Norifumi Nakamura
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Editorial: The Earliest-Born Cortical Neurons as Multi-Tasking Pioneers: Expanding Roles for Subplate Neurons in Cerebral Cortex Organization and Function.
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Bioscience, Biotechnology and Biochemistry 85(1):2020, 168-180. DOI:10.1093/bbb/zbaa024 - Saori Miwa, Ayako M. Watabe, Yohta Shimada, Takashi Higuchi, Hiroshi Kobayashi, Takahiro Fukuda, Fusao Kato, Hiroyuki Ida, Toya Ohashi
Efficient engraftment of genetically modified cells is necessary to ameliorate 1 central nervous system involvement of murine model of mucopolysaccharidosis type II by hematopoietic stem cell targeted gene therapy.
Molecular Genetics and Metabolism 130:2020, 262-273. DOI:10.1016/j.ymgme.2020.06.007 - Masami Ishido, Eiko Shimaya
Electromagnetic fields (EMF) facilitate cell migration and BrdU incorporation during an EMF-sensitive phase in a rat neurosphere assay in vitro.
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Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.
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Enhanced homologous recombination by the modulation of targeting vector ends.
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Enhanced retrieval of taste associative memory by chemogenetic activation of locus coeruleus norepinephrine neurons.
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Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages.
Cell death discovery 6:2020, 1-14. DOI:10.1038/s41420-020-00300-3 - Miyagawa Y, Nukaga S, Mori T, Fujiwara-Tani R, Fujii K, Mori S, Goto K, Kishi S, Sasaki T, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H
Evaluation of cancer-derived myocardial impairments using a mouse model.
Oncotarget 11:2020, 3712-3722. DOI:10.18632/oncotarget.27759 - Amodio P., Shigeno, S. Ostojić L.
Evolution of Intelligence in cephalopods.
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Expression patterns of SLIT/ROBO mRNAs reveal a characteristic feature in the entorhinal-hippocampal area of macaque monkeys.
BMC Res Notes 262(13):2020, 1-6. DOI:10.1186/s13104-020-05100-7 - Yoshida K, Ito MA, Sato N, Obayashi K, Yamamoto K, Koizumi S, Tanaka S, Furuta K, Matsuoka I
Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation. .
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FLCN alteration drives metabolic reprogramming towards nucleotide synthesis and cyst formation in salivary gland.
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Fracture Risk Assessment Tool May Not Indicate Bone Fragility in Women With Type 2 Diabetes.
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Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.
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GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia.
Gastroenterology 158:2020, 1650-1666. DOI:10.1053/j.gastro.2020.01.046 - Alavi S, Ghadiri H, Dabirmanesh B, Moriyama K, Khajeh K, Masai H.
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High Sensitivity In Vivo Imaging of Cancer Metastasis Using a Near-Infrared Luciferin Analogue seMpai.
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Hippocampal 7α-hydroxylated neurosteroids are raised by training and bolster remote spatial memory with increase of the spine densities.
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HNF1a controls glucagon secretion in pancreatic a-cells through modulation of SGLT1.
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Impact of tissue macrophage proliferation on peripheral and systemic insulin resistance in obese mice with diabetes.
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Neonatology -:2020, 1-8. DOI:10.1159/000511085 - Tetsuya Sasaki, Saki Tome, Yosuke Takei
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Linear Consecutive Hexaoxazoles as G4 Ligands Inducing Chair-type Anti-parallel Topology of Telomeric G-Quadruplex.
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Malic enzyme 1 is associated with tumor budding in oral squamous cell carcinomas.
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PLOS Genetics 16(9):2020, e1009048. DOI:10.1371/journal.pgen.1009048 - Doki C, Nishida K, Saito S, Shiga M, Ogara H, Kuramoto A, Kuragano M, Nozumi M, Igarashi M, Nakagawa H, Kotani S, Tokuraku K.
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Mouse hair significantly lightened through replacement of the cysteine residue in the N-terminal domain of Mc1r using the CRISPR/Cas9 system.
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Phosphorylation of the Anaphase Promoting Complex activator FZR1/ CDH1 is required for Meiosis II entry in mouse male germ cell.
Scientific Reports 10:2020, 10094. DOI:10.1038/s41598-020-67116-0 - Christian Hartmann, Ysabel Alessa Schwietzer, Tetsuhisa Otani, Mikio Furuse, Klaus Ebnet
Physiological functions of junctional adhesion molecules (JAMs) in tight junctions.
Biochimica et biophysica acta. Biomembranes 1862(9):2020, 183299-183299. DOI:10.1016/j.bbamem.2020.183299 - Onishi R, Sato K, Murano K, Negishi L, Siomi H, Siomi MC.
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Cancers 12:2020, 1-18. DOI:10.3390/cancers12071811 - Mito M, Mishima Y, and Iwasaki S
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MDPI Scholarly Community Encyclopedia-Topic Review 2020:2020, 1-3. - Taishi Kobayashi, Takuro Murakami, Yuu Hirose, and Toshihiko Eki
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Neuroscience Letters 743:2020, 135555. DOI:10.1016/j.neulet.2020.135555 - Fujiwara-Tani R, Fujii K, Mori S, Kishi S, Sasaki T, Ohmori H, Nakashima C, Kawahara I, NishiguchiY, Mori T, Sho M, Kondoh M, Luo Y, Kuniyasu H
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SGLT2 inhibition mediates protection from diabetic kidney disease by promoting ketone body-induced mTORC1 inhibition.
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Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus.
Elife 9:2020, e59545. DOI:10.7554/eLife.59545 - Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H.
Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells.
Biomed Pharmacother. 128:2020, 110330-110340. DOI:10.1016/j.biopha.2020.110330 - Suzuki S, Minamidate T, Shiga A, Ruike Y, Ishiwata K, Naito K, Ishida A, Deguchi H, Fujimoto M, Koide H, Tatsuno I, Ikeda JI, Yamazaki Y, Sasano H, Yokote K.
Steroid metabolites for diagnosing and predicting clinicopathological features in cortisol-producing adrenocortical carcinoma.
BMC Endocr Disord. 20:2020, in press. DOI:10.1186/s12902-020-00652-y - Moe Matsushita, Takanori Nakamura, Hisashi Moriizumi, Hiroaki Miki, Mutsuhiro Takekawa
Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress.
Science Advances 6(26):2020, eaay9778. DOI:10.1126/sciadv.aay9778 - Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, and Noriyuki Sugo
Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons.
The Journal of Neuroscience 40(47):2020, 9012-9027. DOI:10.1523/JNEUROSCI.0319-20.2020 - Lin, Z, Nishikawa, H, Iguchi, Y, Iwanami, A, Kikuchi, M, Toda, S
Sustaining temporal attention prevents habit expression during operant learning in rats.
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Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/pi interaction.
Bioorganic & Medicinal Chemistry Letters 30:2020, 127657. DOI:10.1016/j.bmcl.2020.127657 - Yasuda M, Ma Y, Okabe S, Wakabayashi Y, Su D, Chang YT, Seimiya H, Tera M, Nagasawa K.
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The antimalarial compound atovaquone inhibits Zika and dengue virus infection by blocking E protein-mediated membrane fusion.
Viruses 12:2020, 1475. DOI:10.3390/v1212475 - Tadashi Nakagawa, Satoko Hattori, Tsuyoshi Miyakawa, Keiko Nakayama
The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression.
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The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation.
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The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
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The pentatricopeptide repeat protein PGR3 is required for the translation of petL and ndhG by binding their 5'UTRs.
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Tight Junction Structure and Function Revisited.
Trends in Cell Biology 30(10):2020, 805-817. DOI:10.1016/j.tcb.2020.08.004 - Nakagawa S, Nguyen Pham KT, Shao X, and Doi M
Time-restricted G-protein signaling pathways via GPR176, Gz, and RGS16 set the pace of the master circadian clock in the suprachiasmatic nucleus.
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Translational landscape of protein-coding and non-protein-coding RNAs upon light exposure in Arabidopsis.
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Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway.
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Visually cued fear conditioning test for memory impairment related to cortical function.
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Journal of Japanese Biochemical Society 92(5):2020, 735-739. DOI:10.14952/SEIKAGAKU.2020.920735
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Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a+/- Mice.
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Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice.
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Adiponectin receptor 1 gene is potentially associated with severity of postoperative pain but not cancer pain.
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Anosmin-1 activates vascular endothelial growth factor receptor and its related signaling pathway for olfactory bulb angiogenesis.
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BRUP-1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson's disease model.
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Coordinated Changes in Cell Membrane and Cytoplasm During Maturation of Apoptotic Bleb.
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FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer.
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FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.
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Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis.
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Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle.
Pathobiology 86:2019, 254-262. DOI:10.1159/000501524 - Saori Shinoda, Sho Kitagawa, Shinichi Nakagawa, Fan-Yan Wei, Kazuhito Tomizawa, Kimi Araki, Masatake Araki, Takeo Suzuki and Tsutomu Suzuki,
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Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity.
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Orchestrated ensemble activities constitute a hippocampal memory engram.
Nature Communications 10:2019, 2637. DOI:10.1038/s41467-019-10683-2 - Fujii T, Chiba Y, Nakayama-Imaohji H, Onishi S, Tanaka A, Katami H, Kaji T, Ieiri S, Miki T, Ueno M, Kuwahara T, Shimono R
Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.
J Pediatr Surg 54(12):2019, 2514-2519. DOI:10.1016/j.jpedsurg.2019.08.048 - Ishikawa Y, Okada M, Honda A, Ito Y, Tamada A, Endo N, *Igarashi M
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Mol Brain 12:2019, 93. DOI:10.1186/s13041-019-0510-z - Sanchez-Martin P, Komatsu M.
Physiological Stress Response by Selective Autophagy.
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Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation.
Journal of Neuroscience 39 (22):2019, 4208-4220. DOI:10.1523/JNEUROSCI.2468-18.2019 - Watanabe T, Suzuki H, Kano M
Postnatal Development of Cerebellar Neural Circuits.
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Prefrontal-Enriched SLIT1 Expression in Primate Cortex and its Alteration during Cortical Development.
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Rational engineering of XCaMPs, a multicolor GECI suite for in vivo imaging of complex brain circuit dynamics.
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Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1.
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Front Cell Neurosci, section Cellular Neuropathology 13:2019, 344-350. DOI:10.3389/fncel.2019.00344 - Toshio Fujino and Tetsuya Mitsudomi
Sensitivity and Resistance of MET Exon 14 Mutations in Lung Cancer to Eight MET Tyrosine Kinase Inhibitors In Vitro.
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SIRT7 regulates the nuclear export of NF-kB p65 by deacetylating Ran.
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Stress augments the rewarding memory of cocaine via the activation of brainstem-reward circuitry.
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Suzuki-Miyaura Cross-Coupling of 1,8-Diaminonaphthalene (dan)-Protected Arylboronic Acids.
ACS CATAL 10:2019, 352-357. DOI:10.1021/acscatal.9b03667 - Chi-Wai Fung, Go Fukada, Yuichiro Mutoh, Noriko Tsuchida, Shinchi Saito
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The effect of MR1 ligand glycol-analogues on mucosal-associated invariant T (MAIT) cell activation.
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The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells.
Cancer Res 80:2019, 471-483. DOI:10.1158/0008-5472.CAN-19-1196 - Ahmat Amin MKB, Shimizu A, Ogita H.
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Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter.
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Whole-brain Block-Face Serial Microscopy Tomography at Subcellular Resolution Using FAST.
Nat Protoc 14 (5):2019, 1509-1529. DOI:10.1038/s41596-019-0148-4 - Sadaiwa Yorimoto, Akira Tsubouchi, Haruki Mizoguchi, Hideaki Oikawa, Yoshiaki Tsunekawa, Tomoya Ichino, Satoshi Maeda and Hiroki Oguri
Zn(OTf)2-mediated annulations of N-propargylated tetrahydrocarbolines: divergent synthesis of four distinct alkaloidal scaffolds.
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A method of producing genetically manipulated mouse mammary gland.
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A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway.
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Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP.
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ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus.
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Analysis of Neuro-Neuronal Synapses Using Embryonic Chick Ciliary Ganglion via Single-Axon Tracing, Electrophysiology, and Optogenetic Techniques.
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Analysis of the neuronal network of the medullary respiratory center in transgenic rats expressing archaerhodopsin-3 in Phox2b-expressing cells.
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Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway.
Cell Death Dis. 10(2):535-540, 2019. DOI:10.1038/s41419-019-1356-0 - Saito T., Komatsu M. (19人中19番目)
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Calvarial Bone Implantation and in vivo Imaging of Tumor Cells in Mice.
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Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.
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Chemically modified antisense oligonucleotide against ARL4C inhibits primary and metastatic liver tumor growth.
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Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.
Biochem Biophys res Commun 509:89-95, 2019. DOI:10.1016/j.bbrc.2018.12.068 - Kimura H, Yamamoto H, Harada T, Fumoto K, Osugi Y, Sada R, Maehara N, Hikita H, Mori S, Eguchi H, Ikawa M, Takehara T, Kikuchi A.
CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy.
Clin Cancer Res. 25:1936-1947, 2019. DOI:10.1158/1078-0432.CCR-18-2124 - Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.
CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.
Oncogene 14:2580-2594, 2019. DOI:10.1038/s41388-018-0603-7 - Bando Y*, Sakamoto M* (Co-first and corresponding author), Kim S, Ayzenshtat I, Yuste R.
Comparative evaluation of genetically encoded voltage indicators.
Cell Reports 26(3):802-813, 2019. DOI:10.1016/j.celrep.2018.12.088 - Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy.
Pathobiology 86:182-189, 2019. DOI:10.1159/000496027 - Furusho, K., T. Shibata, R. Sato, R. Fukui, Y. Motoi, Y. Zhang, S. I. Saitoh, T. Ichinohe, M. Moriyama, S. Nakamura, and K. Miyake.
Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.
Int Immunol. 31:167-173, 2019. DOI:10.1093/intimm/dxy075 - Naniwa K., Sugimoto Y., Osuka K. and Aonuma H.
Defecation initiates walking in the cricket Gryllus bimaculatus.
J. Insect Physiol. 112:117-122, 2019. DOI:10.1016/j.jinsphys.2018.11.004 - Sashida G, Oshima M, Iwama A.
Deregulated Polycomb functions in myeloproliferative neoplasms.
Int J Hematol 110(2):170-178, 2019. DOI:10.1007/s12185-019-02600-6 - Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.
Oncogene 38:635-655, 2019. DOI:10.1038/s41388-018-0481-z - Serita, T., Miyahara, M., Tanimizu, T., Takahashi, S., Oishi, S., Nagayoshi, T., Tsuji, R., Inoue, H., Uehara, M., Kida, S*.
Dietary magnesium deficiency impairs hippocampus-dependent memories without changes in the spine density and morphology of hippocampal neurons in mice.
Brain Res Bull. 144:149-157, 2019. DOI:10.1016/j.brainresbull.2018.11.019 - Yoshitomi S, Takahashi Y, Imai K, Koshimizu E, Miyatake S, Nakashima M, Saitsu H, Matsumoto N, Kato M, Fujita T, Ishii A, Hirose S, Inoue Y.
Different types of suppression-burst patterns in patients with epilepsy of infancy with migrating focal seizures (EIMFS).
Seizure 65:118-123, 2019. DOI:10.1016/j.seizure.2019.01.009 - Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Mizutani A, et al.
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
Journal of Medicinal Chemistry 62(7):3407-3427, 2019. DOI:10.1021/acs.jmedchem.8b01888 - Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI.
Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
J. Exp. Med. 216:950-965, 2019. DOI:10.1084/jem.20180900 - Takanori NOZAWA, Masayasu OKADA, Manabu NATSUMEDA, Takeyoshi EDA, Hideaki ABE, Yoshihiro TSUKAMOTO, Kouichirou OKAMOTO, Makoto OISHI, Hitoshi TAKAHASHI, Yukihiko FUJII, and Akiyoshi KAKITA
EGFRvIII is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma.
Neurologia medico-chirurgica (Tokyo) 59(3):89-97, 2019. DOI:10.2176/nmc.oa.2018-0078 - Tome S, Sasaki T, Takahashi S, Takei Y.
Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic-polycytidylic acid in inducing fetal loss.
Experimental Animals Volume 68 Issue 4:491-497, 2019. DOI:10.1538/expanim.19-0038 - Noritake A, Nakamura K.
Encoding prediction signals during appetitive and aversive Pavlovian conditioning in the primate lateral hypothalamus.
Journal of neurophysiology 121(2):396-417, 2019. DOI:10.1152/jn.00247.2018 - Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N
Forkhead box protein A1 confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.
J Cell Biochem. 120:2259-2270, 2019. DOI:10.1002/jcb.27551 - Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H.
Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo.
J Physiol Sci. 69(1):65-77, 2019. DOI:10.1007/s12576-018-0618-4 - Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K.
Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.
Addict Biol 25(1):e12723, 2019. DOI:10.1111/adb.12723 - Jun Watanabe, Manabu Natsumeda, Masayasu Okada, Daiki Kobayashi, Yu Kanemaru, Yoshihiro Tsukamoto, Makoto Oishi, Akiyoshi Kakita, Yukihiko Fujii
High detection rate of MYD88 mutations in cerebrospinal fluid from patients with central nervous system lymphomas.
JCO Precision Oncology :in press, 2019. - Kamil M, Shinsato Y, Higa N, Hirano T, Idogawa M, Takajo T, Minami K, Shimokawa M, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K.
High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme.
British Journal of Cancer 120(8):819-826, 2019. DOI:10.1038/s41416-019-0413-x - Htun Y, Nakamura S, Nakao Koyano K, Ohta K, Morimoto A, Wakabayashi T, Sugino M, Fujioka K, Kato I, Kondo S, Yasuda S, Miki T, Ueno M, Kusaka T
Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.
Scientific Reports 9:4088, 2019. DOI:10.1038/s41598-019-40674-8 - Umehara T, Mori R, Mace K, Murase T, Abe Y, Yamamoto T, Ikematsu K
Identification of specific microRNAs in neutrophils of type 2 diabetic mice: overexpression of microRNA-129-2-3p accelerates diabetic wound healing.
Diabetes 68(3):617-630, 2019. DOI:10.1124/jpet.118.253922 - Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
Neuroscience Resarch 139:63-68, 2019. DOI:10.1016/j.neures.2018.08.016 - Yosuke Takei, Saki Tome, Tetsuya Sasaki
Intracellular transport of NMDA receptors and Schizophrenia.
Japanese Journal of Biological Psychiatry :in press, 2019. - *Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, R?os A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y
Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.
The Journal of Neuroscience 39(3):485-502, 2019. DOI:10.1523/JNEUROSCI.1584-18.2018 - Toyokuni S
Iron Addiction with Ferroptosis-resistance in Asbestos-induced Mesothelial Carcinogenesis: Toward the Era of Mesothelioma Prevention.
Free Radical Biology & Medicine 133:206-215, 2019. DOI:10.1016/j.freeradbiomed.2018.10.401 - Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.
Cerebral Cortex 29(9):3738-3751, 2019. DOI:10.1093/cercor/bhy253 - Tsutomu Fukuda, Yusuke Nanjo, Masahiro Fujimoto, Kenyu Yoshida, Yuko Natsui, Fumito Ishibashi, Fumiyasu Okazaki, Hideto To, Masatomo Iwao
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
Bioorganic and Medicinal Chemistry 27 (2):265－277, 2019. DOI:10.1016/j.bmc.2018.11.037 - Miyazaki T, Chowdhury S, Yamashita T, Matsubara T, Yawo H, Yuasa H, Yamanaka A.
Large Timescale Interrogation of Neuronal Function by Fiberless Optogenetics Using Lanthanide Micro-particles. 26(4):1033-1043.e5.
Cell Rep. 26(4):1033-1043.e5., 2019. DOI:10.1016/j.celrep.2019.01.001 - N Shiina
Liquid- and solid-like RNA granules form through specific scaffold proteins and combine into biphasic granules.
J. Biol. Chem. 294:107149 - 107149, 2019. DOI:10.1074/jbc.RA118.005423 - M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T,Oike Y.
Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice.
Circ J. 2019 Jan 25;83(2):368-378, 2019. DOI:10.1253/circj.CJ-18-0925 - Kawahara I, Goto K, Kodama K, Luo Y, Fujiwara-Tani R, Mori T, Miyagawa Y, Tanaka H, Kodama H, Hirayama A, Hosoito N, Taniguchi Y, Miki Y, Kuniyasu H
Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle.
Pathobiology 86:254-262, 2019. DOI:10.1159/000501524 - Iwatani Y, Ogawa, H, Shidara H, Sakura M, Sato T, Hojo MK, Honma A, Tsurui K
Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals.
Advanced Robotics :in press, 2019. - Ueno T, Kaomatsu M
Measuring Nonselective and Selective Autophagy in the Liver.
Methods Mol Biol. 1880, 2019. DOI:10.1007/978-1-4939-8873-0_34 - Keisuke Iida, Yamato Tsushima, Yue Ma, Shadi Sedghi Masoud, Mai Sakuma, Tomomi Yokoyama, Wataru Yoshida, Kazunari Ikebukuro, Kazuo Nagasawa
Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole.
Bioorg. Med. Chem. 27:1742-1746, 2019. DOI:10.1016/j.bmc.2019.02.056 - Sakayori N, Kato S, Sugawara M, Setogawa S, Fukushima H, Ishikawa R, Kida S, Kobayashi K.
Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus.
Mol Brain 12:13, 2019. DOI:10.1186/s13041-019-0431-x - Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H.
mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model.
Pharmacol Biochem Behav.? 176:1-5, 2019. DOI:10.1016/j.pbb.2018.11.003 - Park S, Nayantai E, Komatsu T, Hayashi H, Mori R, Shimokawa I
NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning.
J Gerontol A Biol Sci Med Sci. :in press, 2019. DOI:10.1093/gerona/gly282 - Hosoda, H., *Kida, S
NSP-C contributes to the upregulation of CLOCK/BMAL1-mediated transcription.
Cytotechnology 71:453-460, 2019. DOI:10.1007/s10616-018-0266-9 - Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Yamanaka A, Hikida T, Manabe H, Yamaguchi M.
Opposing roles of dopamine receptor D1- and D2-expressing neurons in the anteromedial olfactory tubercle in acquisition of place preference in mice.
Front Behav Neurosci 13:50, 2019. DOI:10.3389/fnbeh.2019.00050 - Liu Y, Ohshiro T, Sakuragi S, Koizumi K, Mushiake H, Ishizuka T, Yawo H.
Optogenetic study of the response interaction among multi-afferent inputs in the barrel cortex of rats.
Sci Rep. 9(1):3917, 2019. DOI:10.1038/s41598-019-40688-2 - Ghandour K#,?Ohkawa N#,＊, Fung CCA#, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, Nishizono H, Matsuo M, Osanai M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Kitamura T, Fukai T, Inokuchi K＊?(#Equally contributed,?＊Corresponding authors)
Orchestrated ensemble activities constitute a hippocampal memory engram.
Nature Communications 10(1):2637, 2019. DOI:10.1038/s41467-019-10683-2 - Nagase, M., Mikami, K., and Watabe, A.M.# (#責任著者)
Parabrachial-to-amygdala control of aversive learning.
Current Opinion in Behavioral Sciences :in press, 2019. - Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T
Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation deficient mice.
Neuropsychopharmacology Reports 39:61-66, 2019. DOI:10.1002/npr2.12044 - Okada, K., Araki, M., Sakashita, T., Ma, B., Kanda, R., Yanagitani, N., Horiike, A., Koike, S., Oh-Hara, T., Watanabe, K., Tamai, K., Maemondo, M., Nishio, M., Ishikawa, T., Okuno, Y., Fujita, N. and *Katayama, R.
Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance.
EBioMedicine 41:105-119, 2019. DOI:10.1016/j.ebiom.2019.01.019 - Tetsuya Sasaki (Corresponding Author), Yusuke Komatsu, Tetsuo Yamamori (Corresponding Author)
Prefrontal-Enriched SLIT1 Expression in Primate Cortex and its Alteration during Cortical Development.
Japanese Journal of Biological Psychiatry 30(2):in press, 2019. - Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning.
Neurochem Int 126:11-18, 2019. DOI:10.1016/j.neuint.2019.02.011 - Shimizu H., Takeishi S., Nakatsumi H., Nakayama KI.
Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells.
JCI Insight 4:pii-125138, 2019. DOI:10.1172/jci.insight.125138 - Yoshitomi S, Takahashi Y, Yamaguchi T, Oboshi T, Horino A, Ikeda H, Imai K, Okanishi T, Nakashima M, Saitsu H, Matsumoto N, Yoshimoto J, Fujita T, Ishii A, Hirose S, Inoue Y.
Quinidine therapy and therapeutic drug monitoring in four patients with KCNT1 mutations.
Epileptic Disorders 21(1):48-54, 2019. DOI:10.1684/epd.2019.1026 - Koso H, Tsuhako A, Matsubara D, Fujita Y, Watanabe S.
Ras activation in retinal progenitor cells induces tumor formation in the eye.
Exp. Eye Res. 180:39-42, 2019. DOI:10.1016/j.exer.2018.11.025 - Ikuma Kato, Mitsuko Furuya, Masaya Baba, Yoichi Kameda, Masanori Yasuda, Koshiro Nishimoto, Masafumi Oyama, Toshinari Yamasaki, Osamu Ogawa, Hitoshi Niino, Noboru Nakaigawa, Yuta Yano, Kazumasa Sakamoto, Yoji Urata, Kazuya Mikami, Shigetaka Yamasaki, Reiko Tanaka, Toshio Takagi, Tsunenori Kondo, Yoji Nagashima
RBM10‐TFE3 Renal Cell Carcinoma Characterized by Paracentric Inversion with Consistent Closely Split Signals in Break‐apart Fluorescence in situ Hybridization: Study of Ten Cases and a Literature Review.
Histopathology 75(2):254-265, 2019. DOI:10.1111/his.13866 - Imanishi, T., M. Unno, W. Kobayashi, N. Yoneda, S. Matsuda, K. Ikeda, T. Hoshii, A. Hirao, K. Miyake, G. N. Barber, M. Arita, K. J. Ishii, S. Akira, and T. Saito.
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.
Life Sci Alliance 2(1):e201800282, 2019. DOI:10.26508/lsa.201800282 - Kida, S
Reconsolidation/Destabilization, Extinction and Forgetting of Fear Memory as Therapeutic Targets for PTSD.
Psychopharmacology 236:49-57, 2019. DOI:10.1007/s00213-018-5086-2 - Ishifune, C., Tsukumo, SI., Maekawa Y., Hozumi, K., Chung, DH., Motozono, C., Yamasaki, S., Nakano, H., Yasutomo, K.
Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.
PLoS Biol. 17:e3000262, 2019. DOI:10.1371/journal.pbio.3000262 - Hara S, Fukumura S, Ichinose H
Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity.
J Biol Chem 294:1420-1427, 2019. DOI:10.1074/jbc.RA118.005280 - Nakajo H, Ishibashi K, Aoyama K, Kubota S, Hasegawa H, Yamaguchi N, Yamaguchi N
Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling.
Biochem Biophys Res Commun. 511:765-771, 2019. DOI:10.1016/j.bbrc.2019.02.130 - Sugiyama S., Yumimoto K., Inoue I., Nakayama KI.
SCF(Fbxw7) ubiquitylates KLF7 for degradation in a manner dependent on GSK-3?mediated phosphorylation.
Genes Cells 24:354-365, 2019. DOI:10.1111/gtc.12680 - Tatsukawa T, Raveau M, Ogiwara I, Hattori S, Miyamoto H, Mazaki E, Itohara S, Miyakawa T,Montal M, Yamakawa K*
Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity.
Mol Autism 10:15, 2019. DOI:10.1186/s13229-019-0265-5 - Gong B., Kiyotani K., Sakata S., Nagano S., Kumehara S., Baba S., Besse B., Yanagitani N., Friboulet L., Nishio M., Takeuchi K., Kawamoto H., Fujita N., *Katayama R.
Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer.
J Exp Med. 216(4):982-1000, 2019. DOI:10.1084/jem.20180870 - Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F.
Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling.
Biochemical and Biophysical Research Communications 509(3):700-706, 2019. DOI:10.1016/j.bbrc.2018.12.164 - Mitsuhiro Wada, Hiroyuki Suzuki, Mitsuyasu Kato, Hideaki Oikawa, Akira Tsubouchi, Hiroki Oguri
Stereo-Divergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Anti-proliferative Activity.
ChemBioChem 20(10):1273-1281, 2019. DOI:10.1002/cbic.201800815 - Yu Buchin, Yuka Sakemi, Ruriko Hamashima, Yuko Morioka, Daisuke Yamanaka,
Fumihiko Hakuno, Shin-ichiro Takahashi, Kazutoshi Shindo
Structures and biological activities of new carnosic acid- and carnosolrelated compounds generated by heat treatment of rosemary.
Phytochemistry Letters 30:43-48, 2019. DOI:10.1016/j.phytol.2019.01.005 - Tsutomu Fukuda, Yuri Matsuo, Fuyuki Matsuoka, Naoki Yoshioka, Gen Onodera, Masanari Kimura, Fumito Ishibashi, Masatomo Iwao
Synthesis and evaluation of topoisomerase I inhibitors possessing the 5,13-dihydro-6H-benzo[6,7]indolo[3,2-c]quinolin-6-one scaffold.
Heterocycles 99:1032-1052, 2019. DOI:10.3987/COM-18-S(F)70 - Yue Ma, Keisuke Iida, Shogo Sasaki, Takatsugu Hirokawa, Heddi Brahim, Anh Tuan Phan, Kazuo Nagasawa
Synthesis and telomeric G-quadruplex-stabilizing ability of macrocyclic hexaoxazoles bearing three side chains.
Molecules 24:263, 2019. DOI:10.3390/molecules24020263 - Ashida, Y., Yanagita, R. C., Kawanami, Y., Okamura, M., Dan, S. and?Irie, K.
Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin.
Heterocycles 99(2):942-957, 2019. DOI:10.3987/COM-18-S(F)60 - Nishiguchi Y, Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Kishi S, Mori S, Goto K, Yasui W, Sho M*, Kuniyasu H
Targeting claudin-4 enhances CDDP-chemosensitivity of gastric cancer.
Oncotarget 10:2189-2202, 2019. DOI:10.18632/oncotarget.26758 - Mito M.,Kadota M., Nakagawa S.*, Iwasaki S.*
tChIP-Seq: cell-type-specific Eepigenome profiling.
J. Vis. Exp 143:e58298, 2019. DOI:10.3791/58298 - Masaya Baba, Mitsuko Furuya, Takanobu Motoshima, Martin Lang, Shintaro Funasaki, Wenjuan Ma, Hong-Wei Sun, Hisashi Hasumi, Ying Huang, Ikuma Kato, Tsuyoshi Kadomatsu, Yorifumi Satou, Nicole Morris, Baktiar O. Karim, Lilia Ileva, Joseph D. Kalen, Luh Ade Wilan Krisna, Kimi Araki et al.
TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease.
Molecular Cancer Research 17:1613-1626, 2019. DOI:10.1158/1541-7786.MCR-18-1235 - Iwasaki S.*, Iwasaki W., Takahashi M., Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T.*, and Ingolia NT.*
The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA.
Mol. Cell 73:1-10, 2019. DOI:10.1016/j.molcel.2018.11.026 - Liang L, Teh D, Dinh ND, Chen W, Chen Q, Wu Y, Chowdhury S, Yamanaka A, Sum TC, Chen CH, Thakor N, All A, Liu X
Upconversion Amplification through Dielectric Superlensing Modulation.
Nat Commun 10:1391, 2019. DOI:10.1038/s41467-019-09345-0 - 平石哲也、棗田学、岡田正康、大石誠、藤井幸彦
悪性髄膜腫における個別化医療の可能性.
Precision Medicine 2(1):54-58, 2019. - Ito N., Mohammad B., A., Shah A., I., A., and Ohta K.
Transdifferentiation of human somatic cells by ribosome.
Development Growth & Differentiation 60:241-247, 2018. DOI:10.1111/dgd.12538 - 山本一男
"サイズ"で斬る生物学への誘い.
実験医学 36(13):2168-2173, 2018. - Mizotani Y, Suzuki M, Hotta K, Watanabe H, Shiba K, Inaba K, Tashiro E, Oka K and Imoto M.
14-3-3εa directs the pulsatile transport of basal factors towards the apical domain for lumen growth in tubulogenesis.
Proc. Natl. Acad. Sci. USA 115:E8873-E8881, 2018. DOI:10.1073/pnas.1808756115 - Gong, B., Oh-Hara, T., Fujita, N. and *Katayama, R.
3D culture system containing gellan gum restores oncogene dependence in ROS1 rearrangements non-small cell lung cancer.
Biochem. Biophys. Res. Commun., 501:527-533, 2018. DOI:10.1016/j.bbrc.2018.05.031 - Horai T, Hishimoto A, Otsuka I, So T, Mouri K, Shimmyo N, Boku S, Okishio N, Sora I.
A Cross-Sectional Study Exploring Useful Indicators for Low Bone Mineral Density in Male Alcoholic Patients.
Neuropsychiatr Dis Treat 14:663-669, 2018. DOI:10.2147/NDT.S153360 - Kosuke Ishikawa, Yuta Kobayashi, Yutaro wakabayashi, Shinya Watanabe and Kentaro Semba
A highly sensitive trap vector system for isolating reporter cells and identification of responsive genes.
Biology Methods and Protocols 3:bpy003, 2018. DOI:10.1093/biomethods/bpy003 - Nakajima C, Kamimoto K, Miyajima K, Matsumoto M, Okazaki Y, Kobayashi-Hattori K, Shimizu M, Yamane T, Oishi Y, Iwatsuki K.
A new method for identifying mouse pancreatic ducts.
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A novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analyses.
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Brain & Development 40(10):926-930, 2018. DOI:10.1016/j.braindev.2018.06.005 - Zhang Y, Nakano D, Guan Y, Hitomi H, Masaki T, Kobara H, Sugaya Y, Nishiyama A.
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Cancer Res 78, 2018. DOI:10.1158/0008-5472 - Takahashi Y, Hamasaki M, Aoki M, Koga K, Koshikawa N, Miyamoto S, Nabeshima K.
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Anticancer Res 38:4257-4266, 2018. DOI:10.21873/anticanres.12722 - Ichimura Y, Komatsu M.
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Front Oncol. 8, 2018. DOI:10.3389/fonc.2018.00210 - Moriya S, Yamashita A, Kawashima S, Nishi R, Yamanaka A, Kuwaki T.
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Neuroscience 386:16-23, 2018. DOI:10.1016/j.neuroscience.2018.06.027 - Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, Endo M, Zhu S, Fan H, Horiguchi H, Morinaga J, Terada K, Yoshizawa T, Yamagata K, Oike Y
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J Biol Chem 293:1596-1609, 2018. DOI:10.1074/jbc.M117.814996 - Ichinose H, Inoue KI, Arakawa S, Watanabe Y, Kurosaki H, Koshiba S, Hustad E, Takada M, Aasly JO
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J Neural Transm 125:45-52, 2018. DOI:10.1007/s00702-017-1784-x - Tsurumaru, H., Ito, N., Mori, K., Wakai, S., Uchiyama, T., Iino, T., Hosoyama, A., Ataku, H., Nishijima, K., Mise, M., Shimizu, A., Harada, T., Horikawa, H., Ichikawa, N., Sekigawa, T., Jinno, K., Tanikawa, S., Yamazaki, J., Sasaki, K., Yamazaki, S., Fujita, N., and Harayama, S.,
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Scientific Reports 8 8:15149, 2018. DOI:10.1038/s41598-018-33541-5 - M. Ishido*
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J. Applied Life Sci. Intl. 19:2394-1103, 2018. DOI:10.9734/JALSI/2018/45377 - Fink J, Jackney A, Matsumoto M, Maekawa T, Nakazato K, Horie S.
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Physician. Sportsmedicine 2 47(1):10-14., 2018. DOI:10.1080/00913847.2018.1526626 - Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrian Marchand, Fernaldo Richtia Winnerdy, Valerie Gabelica, Anh Tuan Phan, Masato Katahira & Kazuo Nagasawa
Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound.
ChemBioChem 19:2268-2272, 2018. DOI:10.1002/cbic.201800425 - Shimizu Y, Tamada S, Kato M, Hirayama Y, Takeyama Y, Iguchi T, Sadar MD, Nakatani T.
Androgen Receptor Splice Variant 7 Drives the Growth of Castration Resistant Prostate Cancer without Being Involved in the Efficacy of Taxane Chemotherapy.
J Clin Med 7(11):E444, 2018. DOI:10.3390/jcm7110444 - Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Nishiguchi Y, Kishi S, Mori S, Goto K, Kondoh M, Kuniyasu H
Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer.
Oncotarget 9(100):37367-37378, 2018. DOI:10.18632/oncotarget.26427 - Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki E, Takeda A, Le HPN, Hayashi H, Hiasa M, Moriyama Y, Ikenaka K, Tanaka KF, Koizumi S
Anti-Depressant Fluoxetine Reveals its Thrapeutic Effect Via Astrocytes.
E BioMedicine 32:72-83, 2018. DOI:10.1016/j.ebiom.2018.05.036 - Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, R?os A, Kawabata M, Kimura M, Sakai Y, *Isomura Y
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Neuroscience 388:297-316, 2018. DOI:10.1016/j.neuroscience.2018.07.039 - Saika M, Inoue D, Nagase R, Sato N, Tsuchiya A, Yabushita T, Kitamura T, Goyama S.
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BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes.
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Cell Rep 24(8):2191-2195, 2018. DOI:10.1016/j.celrep.2018.07.057 - Tatsunori Nishimura, Asuka Nakata, Xiaoxi Chen, Kurumi Nishi, Makiko Meguro-Horike, Soichiro Sasaki, Kenji Kita, Shin-ichi Horike, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Takahiko Murayama, Susumu Kohno, Chiaki Takahashi, Naofumi Mukaida, Seiji Yano, Tomoyoshi Soga, Arinobu Tojo, Noriko Gotoh
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Oncogene 38(14):2464-2481, 2018. DOI:10.1038/s41388-018-0589-1 - Umeda M, Koga T, Ichinose K, Igawa T, Sato T, Takatani A, Shimizu T, Fukui S, Nishino A, Horai Y, Hirai Y, Kawashiri S.-Y, Iwamoto N, Aramaki T, Tamai M, Nakamura H, Yamamoto K, Abiru N, Origuchi T, Ueki Y and Kawakami A
CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus.
Clinical Immunology 187:50-57, 2018. DOI:10.1016/j.clim.2017.10.004 - Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration.
Neurochem Int 119:190-198, 2018. DOI:10.1016/j.neuint.2018.01.003 - Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H.
Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
Scientific Reports 8:e14827, 2018. DOI:10.1038/s41598-018-33139-x - Morrison, S.F., Nakamura, K.
Central mechanisms for thermoregulation.
Annual Review of Physiology 81:285-308, 2018. DOI:10.1146/annurev-physiol-020518-114546 - Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR.
Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.
Cell Reports 24:2196-2210, 2018. DOI:10.1016/j.celrep.2018.07.056 - Ryo Tanifuji, Kento Koketsu, Michiko Takakura, Ryutaro Asano, Atsushi Minami, Hideaki Oikawa, Hiroki Oguri
Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3.
J. Am. Chem. Soc. 140(34):10705?10709, 2018. DOI:10.1021/jacs.8b07161 - Tomoaki Taniguchi, Akira Tsubouchi, Yuki Imai, Junpei Yuasa, Hiroki Oguri
Chiroptical Inversion of Europium(III) Complexes by Changing a Remote Stereogenic Center of a C2-symmetric Bispyrrolidinoindoline Manifold.
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Front Immunol 9:1491, 2018. DOI:10.3389/fimmu.2018.01491 - Noguchi K, Konno M, Eguchi H, Kawamoto K, Mukai R, Nishida N, Koseki J, Wada H, Akita H, Satoh T, Marubashi S, Nagano H, Doki Y, Mori M, Ishii H.
c-Met affects gemcitabine resistance during carcinogenesis in a mouse model of pancreatic cancer.
Oncol Lett 16(2):1892-1898, 2018. DOI:10.3892/ol.2018.8793 - Sato, R., A. Kato, T. Chimura, S. I. Saitoh, T. Shibata, Y. Murakami, R. Fukui, K. Liu, Y. Zhang, J. Arii, G. H. Sun-Wada, Y. Wada, T. Ikenoue, G. N. Barber, T. Manabe, Y. Kawaguchi, and K. Miyake.
Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.
Nat Immunol 19(10):1071-1082, 2018. DOI:10.1038/s41590-018-0203-2 - Aonuma H., Totani Y., Sakakibara M., Lukowiak K. and Ito E.
Comparison of brain monoamine content in three populations of Lymnaea that correlates with taste-aversive learning ability.
Biophys. Physicobiol. 15:129-135, 2018. DOI:10.2142/biophysico.15.0_129 - Ida-Yonemochi H, Morita W, Sugiura N, Kawakami R, Morioka Y, Takeuchi Y, Sato T, Shibata S, Watanabe H, Imamura T, Igarashi M, Ohshima H, Takeuchi K
Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.
Sci Rep 8:17134-, 2018. DOI:10.1038/s41598-018-35412-5 - Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T
Deficiency of AMPA receptor-palmitoylation aggravates seizure susceptibility.
Journal of Neuroscience 38:10220-10235, 2018. DOI:10.1523/JNEUROSCI.1590-18.2018 - Zhou L, Hossain MI, Yamazaki M, Abe M, Natsume R, Konno K, Kageyama S, Komatsu M, Watanabe M, Sakimura K, Takebayashi H.
Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype.
J Neurochem 147:557-572, 2018. DOI:10.1111/jnc.14591 - Karnakar Reddy Bonepally, Takahisa Hiruma, Haruki Mizoguchi, Kyohei Ochiai, Shun Suzuki, Hideaki Oikawa, Aki Ishiyama, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Omura, Hiroki Oguri
Design and De Novo Synthesis of 6-Aza-artemisinins.
Org. Lett. 20(15):4667?4671, 2018. DOI:10.1021/acs.orglett.8b01987 - Nana Tsuchiya, Yunosuke Ryu, Takahiro Muraoka, Hiroki Oguri
Design of C2-symmetric alkaloidal chiral amphiphiles and configurational effects on self-assembly.
Org. Biomol. Chem. 16:9305-9313, 2018. DOI:10.1039/C8OB02287A - Yue Ma, Yamato Tsushima, Mai Sakuma, Shogo Sasaki, Keisuke Iida, Sachiko Okabe, Hiroyuki Seimiya, Takatsugu Hirokawa, Kazuo Nagasawa
Development of G-quadruplex ligand for selective induction of parallel-type topology.
Org. Biomol. Chem. 16:7375-7382, 2018. DOI:10.1039/C8OB01702F - Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, and Komuro I.
Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury.
JACC:Basic to Translational Science 12;3(5):639-653, 2018. DOI:10.1016/j.jacbts.2018.07.005 - Brew N, Nakamura S, Hale, N. Azhan, A., Davies, G. I.
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Pediatr Res 84(3):442-450, 2018. DOI:10.1038/s41390-018-0045-5 - Nagai, N., Ohguchi, H., Nakaki, R., Matsumura, Y., Kanki, Y., Sakai, J., Aburatani, H., and Minami, T
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J Neurochem 147(3):344-360, 2018. DOI:10.1111/jnc.14486 - Takayama Y, Ando T, Ichikawa J, Haro H
Effect of Thrombin-Induced MCP-1 and MMP-3 Production Via PAR1 Expression in Murine Intervertebral Discs.
Sci Rep 8(1):11320, 2018. DOI:10.1038/s41598-018-29669-z - Ahmat Amin MKB, Shimizu A, Zankov DP, Sato A, Kurita S, Ito M, Maeda T, Yoshida T, Sakaue T, Higashiyama S, Kawauchi A, Ogita H.
Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1.
Oncogene 37:5416-5434, 2018. DOI:10.1038/s41388-018-0286-0 - Tanaka Y, Higurashi N, Shirasu N, Yasunaga S, Moreira KM, Okano H, Hirose S.
Establishment of a human induced stem cell line (FUi002-A) from Dravet syndrome patient carrying heterozygous R1525X mutation in SCN1A gene.
Stem Cell Research 31:11-15, 2018. DOI:10.1016/j.scr.2018.06.008 - Y. Yamashita, Y. Saito, S. Kikkawa, Y. Mutoh, S. Hosoya, I. Azumaya, S. Saito
Evaluation of the Steric Bulk of Substituents Utilizing the Shuttling Behavior of [2]Rotaxanes with N-Arylpyrrole Moieties.
EUR J ORG CHEM 2019:3412-3420, 2018. DOI:10.1002/ejoc.201801476 - Nakashima C, Yamamoto K, Fujiwara-Tani R, Luo Y, Matsushima S, Fujii K, Ohmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H
Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.
Cancer Sci 109(6):2036-2045, 2018. DOI:10.1111/cas.13594 - Aoyama K, Oshima M, Koide S, Suzuki E, Mochizuki-Kashio M, Kato Y, Tara S, Shinoda D, Hiura N, Nakajima-Takagi Y, Sashida G, Iwama A.
Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.
iScience 9:161-174, 2018. DOI:10.1016/j.isci.2018.10.008 - Wang C, Oshima M, Sato D, Matsui H, Kubota S, Aoyama K, Nakajima-Takagi Y, Koide S, Matsubayashi J, Mochizuki-Kashio M, Nakano-Yokomizo T, Bai J, Nagao T, Kanai A, Iwama A, Sashida G.
Ezh2 loss propagates hypermethylation at T-cell differentiation-regulating genes to promote leukemic transformation.
J Clin Invest 128(9):3872-86, 2018. DOI:10.1172/JCI94645 - Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
Jounal of Clinical Investigation 128(12):5603-5619, 2018. DOI:10.1172/JCI121679 - Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A.
FEAT enhances INSL3 expression in testicular Leydig cells.
Genes to cells 23:952-962, 2018. DOI:10.1111/gtc.12644 - Masaya Baba, Mitsuhiro Endoh, Wenjuan Ma, Hirofumi Toyama, Akiyoshi Hirayama, Keizo Nishikawa, Keiyo Takubo, Hiroyuki Hano, Hisashi Hasumi, Terumasa Umemoto, Michihiro Hashimoto, Nobuko Irie, Chiharu Esumi, Miho Kataoka, Naomi Nakagata, Tomoyoshi Soga, Masahiro Yao, Tomomi Kamba, Takashi Minami, Masaru Ishii, Toshio Suda
Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation.
Journal of Bone and Mineral Research 33(10):1785-1798, 2018. DOI:10.1002/jbmr.3477 - Sulistomo HW, Nemoto T, Yanagita T, Takeya R.
Formin homology 2 domain-containing 3 (Fhod3) controls neural plate morphogenesis in mouse cranial neurulation by regulating multidirectional apical c ….
J Biol Chem 294:2924-2934, 2018. DOI:10.1074/jbc.RA118.005471 - Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women: Chiba bone survey.
Endocr J 65(2):193-202, 2018. DOI:10.1507/endocrj.EJ17-0331 - Kaneko R, Kakinuma T, Sato S, Jinno-Oue A.
Freezing sperm in short straws reduces storage space and allows transport in dry ice.
J Reprod Dev. 64(6):541-545, 2018. DOI:10.1262/jrd.2018-100 - Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Ichikawa J, Osada M, Satoh K, Ozaki Y, Suzuki-Inoue K.
Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis.
J Thromb Haemost 16(5):960-972, 2018. DOI:10.1111/jth.13987 - Hayashida T, Saito Y, Ishii A, Hirose S, Hiraiwa R, Maegaki Y, Ohno K.
Further characterization of CAPOS/CAOS syndrome with the Glu818Lys mutation in the ATP1A3 gene: A case report.
Brain & Development 40(7):576-581, 2018. DOI:10.1016/j.braindev.2018.03.004 - Yokoshima Y, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Kato R, Hozumi J, Abe H, Azuma K, Tsuchida R, Yamada Y, Japanese TR-Cancer Pain Research Group.
Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain: An exploratory study.
Neuropsychopharmacology Report 38:175-181, 2018. DOI:10.1002/npr2.12030 - Kuriyama Y, Hattori M, Mitsui T, Nakano H, Oikawa D, Tokunaga F, Ishikawa O, Shimizu A.
Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency.
Journal of Dermatology 45(5):e108-e109, 2018. DOI:10.1111/1346-8138 - Shiori Miura, Yoshitaka Maeda, Jun Miyamoto, Ena Nakatsukasa, Nobuyoshi Fujisawa, Miki Miwa, Katsuki Nakamura, Kenji Sakimura and Toshikuni Sasaoka
Generation of functional oocytes of common marmoset by xeno-transplantation of ovarian tissue.
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Generation of rat monoclonal antibodies against a deubiquitinase, ovarian tumor domain-containing protein 1.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 37(4):180-184, 2018. DOI:10.1089/mab.2018.0023 - Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
Generation of rat monoclonal antibodies specific for DZIP3.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 37(3):153-157, 2018. DOI:10.1089/mab.2018.0005 - Orr? C*, Szydlowska M*, Taguchi K*, Zavattari P, Perra A, Yamamoto M, Columbano A
Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis.
J Hepatol 69:635-643, 2018. DOI:10.1016/j.jhep.2018.05.010 - Ito-Ishida A, Yamalanchili HK, Shao Y, Baker SA, Heckman LD, Lavery LA, Kim JY, Lombardi LM, Sun Y, Liu Z, Zoghbi HY.
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Glucagonoma With Necrolytic Migratory Erythema: Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.
J Clin Endocrinol Metab 103(7):2417-2423, 2018. DOI:10.1210/jc.2017-02646 - Nishihara S
Glycans in stem cell regulation: from Drosophila tissue stem cells to mammalian pluripotent stem cells.
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Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.
Cell Host Microbe 23(2):254-265, 2018. DOI:10.1016/j.chom.2017.12.014 - Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System.
SLAS Discovery 23(10):1018-1029, 2018. DOI:10.1177/2472555218793066 - Yamauchi Y., Itoh S. et al.
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Hunger and satiety signaling: Modeling two hypothalamomedullary pathways for energy homeostasis.
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Lipids in Health and Disease 17:258, 2018. DOI:10.1186/s12944-018-0908-0 - Matsuyama S, Kage Y, Fujimoto N, Ushijima T, Tsuruda T, Kitamura K, Shiose A, Asada Y, Sumimoto H, Takeya R.
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Experimental Cell research 370(2):699-707, 2018. DOI:10.1016/j.yexcr.2018.07.036 - Hirata T ; Hishimoto A ; Otsuka I ; Okazaki S ; Boku S ; Kimura A ; Horai T ; Sora I
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MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas.
Neurol Med Chir (Tokyo) 58:290-295, 2018. DOI:10.2176/nmc.ra.2018-0044 - Takeda A, Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J, Koizumi S.
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GLIA 66:2366-2384, 2018. DOI:10.1002/glia.23475 - Kokuda R, Watanabe R, Okuzaki D, Akamatsu H, Oneyama C.
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Mobility and biomechanical functions in the aging male: testosterone and the Locomotive Syndrome.
Aging Male 29:1-8, 2018. DOI:10.1080/13685538.2018.1504914 - Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, *Isomura Y, *Kimura M
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Neuron 99(6):1302-1314, 2018. DOI:10.1016/j.neuron.2018.08.002 - Kano M, Watanabe T, Uesaka N, Watanabe M.
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Cell Reports 23:3721-3729, 2018. DOI:10.1016/j.celrep.2018.05.081 - Tamiya Y ; Ouchi A ; Chen R ; Miyazawa S ; Akimoto Y ; Kaneda Y ; Sora I
Neurocognitive Impairments Are More Severe in the Binge-Eating/Purging Anorexia Nervosa Subtype Than in the Restricting Subtype.
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Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function.
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Proc Natl Acad Sci U S A. 115(33):8370-8375, 2018. DOI:10.1073/pnas.1804243115 - S?nchez-Mart?n P, Komatsu M.
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Cancer Discovery 8(11):1438-57, 2018. DOI:10.1158/2159-8290.CD-17-1203 - Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H
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Platelet-Derived TGF-β Induces Tissue Factor Expression via the Smad3 Pathway in Osteosarcoma Cells.
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Poly(ethylene glycol)?poly(lysine) block copolymer?ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.
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Cell Death Discovery 4(104), 2018. DOI:10.1038/s41420-018-0117-7 - Fink J, Matsumoto M, Tamura Y.
Potential application of testosterone replacement therapy as treatment for obesity and type 2 diabetes in men.
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Prednisolone-responsive Postpartum IgG4-related Hypophysitis.
Intern Med 57(3):367-375, 2018. DOI:10.2169/internalmedicine - Miyazawa, Y., Takahashi, Y., Watabe, A.M. and Kato F.
Predominant synaptic potentiation and activation of the right central amygdala are independent of bilateral paracrachial activation in the hemilateral trigeminal inflammatory pain model of rats.
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Reappraising newborn screening for cobalamin C disorder.
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Leukemia 32:2590?2603, 2018. DOI:10.1038/s41375-018-0154-5 - Watanabe E, Fujita T, Shimono M, Koike H, Yasumoto S, Hirose S.
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Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues.
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Oncotarget 9(37):24718-24730, 2018. DOI:10.18632/oncotarget.25339 - Jinnai, W. Nakamura, S. Koyano, K. Yamato, S.
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Brain Dev 40(8):649-661, 2018. DOI:10.1016/j.braindev.2018.04.010 - Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
Resting-state functional connectivity analysis of the mouse brain using intrinsic optical signal imaging of cerebral blood volume dynamics.
Physiological Measurement 39:54003, 2018. DOI:10.1088/1361-6579/aac033 - Miyazaki K, Miyazaki KW, Yamanaka A, Tokuda T, Tanaka KF, Doya K.
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Reward-enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice: A model of attention-deficit/hyperactivity disorder.
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RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
Cancer Science 109(12):4003-4014, 2018. DOI:10.1111/cas.13805 - Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N
Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.
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Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylstyrenes via 1,2-Carbon Migration that Leads to Substituted Naphthalenes.
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Eur J Pharm Sci 117:161-167, 2018. DOI:10.1016/j.ejps.2018.02.016 - Koso H, Nishinakamura R, Watanabe S
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Self-organizing Cortex Generated From Human iPSCs With Combination of FGF2 and Ambient Oxygen.
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Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.
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SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.
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Sci Rep 8:5927, 2018. DOI:10.1038/s41598-018-24257-7 - Tsuge M, Osaki M, Sasaki R, Hirahata M, Okada F
SK-216, a novel inhibitor of plasminogen activator inhibitor-1, suppresses lung metastasis of human osteosarcoma.
Int J Mol Sci 19(3):736, 2018. DOI:10.3390/ijms19030736 - Mitsuko Furuya, Hironori Kobayashi, Masaya Baba, Takaaki Ito, Reiko Tanaka, Yukio Nakatani
Splice-site mutation causing partial retention of intron in the FLCN gene in Birt-Hogg-Dub? syndrome: a case report.
BMC medical genomics 11, 2018. DOI:10.1186/s12920-018-0359-5 - Sumiyoshi K, Koso H, Watanabe S.
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Cancer Sci. 109(5):1513-1523, 2018. DOI:10.1111/cas.13579 - Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T*, Sato K
Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis.
Mol Cancer Res 16(3):554-563, 2018. DOI:10.1158/1541-7786.MCR-17-0393 - Shimizu Y1, Tamada S1, Kato M1, Takeyama Y1, Fujioka M2, Kakehashi A2, Nakatani T1, Wanibuchi H2, Gi M2.
Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer.
Exp Ther Med 16(6):4463-4470, 2018. DOI:10.3892/etm.2018.6787 - Zhang, Z., U. Ohto, T. Shibata, M. Taoka, Y. Yamauchi, R. Sato, N. M. Shukla, S. A. David, T. Isobe, K. Miyake, and T. Shimizu.
Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep 25(12):3371-3381, 2018. DOI:10.1016/j.celrep.2018.11.081 - Ishida, H., U. Ohto, T. Shibata, K. Miyake, and T. Shimizu.
Structural basis for species-specific activation of mouse Toll-like receptor 9.
FEBS Lett 592(15):2636-2646, 2018. DOI:10.1002/1873-3468.13176 - Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Ishitani R, Tokunaga F, Kasuya G, Nureki O.
Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
Nat Commun. 9:4424, 2018. DOI:10.1038/s41467-018-06922-7 - Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ.
Study on the tumor-induced angiogenesis using mathematical models.
Cancer Science 109:15-23, 2018. DOI:10.1111/cas.13395 - Akatsuka S, Li GH, Toyokuni S
Superiority of rat over murine model for studies on the evolution of cancer genome.
Free Radical Research 52:1323-1327, 2018. DOI:10.1080/10715762.2018.1467562 - Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output.
Cell Rep. 25:2704-2715, 2018. DOI:10.1016/j.celrep.2018.11.016 - Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S. and Irie, K.
Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin.
Heterocycles 97(1):478-492, 2018. DOI:10.3987/COM-18-S(T)37 - Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
Systematic review of pre-clinical chronic myeloid leukaemia.
Int J Hematol. 108(5):465-484, 2018. DOI:10.1007/s12185-018-2528-x - Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H
Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
Sci Rep. 8(1):5435, 2018. DOI:10.1038/s41598-018-23810-8 - de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu To, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R
Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds.
EMBO Mol Med 10(10):e9024, 2018. DOI:10.15252/emmm.201809024 - Okada K, Nishizawa K, Setogawa S, Hashimoto K, Kobayashi K.
Task-dependent function of striatal cholinergic interneurons.
Eur J Neurosci 47(10):1174-1183., 2018. DOI:10.1111/ejn.13768 - Kita Y., Katayama Y., Shiraishi T., Oka T., Sato T., Suyama M., Ohkawa Y., Miyata K., Oike Y., Shirane M., Nishiyama M., Nakayama KI.
The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.
Cell Rep. 23:1988-2000, 2018. DOI:10.1016/j.celrep.2018.04.050 - Matsumoto A., Nakayama KI.
The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.
Cell Struct. Funct. 43:75-83, 2018. DOI:10.1247/csf.18005 - Pelka, K., D. Bertheloot, E. Reimer, K. Phulphagar, S. V. Schmidt, A. Christ, R. Stahl, N. Watson, K. Miyake, N. Hacohen, A. Haas, M. M. Brinkmann, A. Marshak-Rothstein, F. Meissner, and E. Latz.
The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.?.
Immunity 48(5):911-922, 2018. DOI:10.1016/j.immuni.2018.04.011 - Lorente J, Velandia C, Leal JA, Garcia-Mayea Y, Lyakhovich A, Kondoh H, LLeonart ME.
The interplay between autophagy and tumorigenesis: exploiting autophagy as a means of anticancer therapy.
Biol Rev Camb Philos Soc. 93, 1:P152?165, 2018. DOI:10.1111/brv.12337 - Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H, Kirita T.
The multifarious functions of pyruvate kinase M2 in oral cancer cells.
Int J Mol Sci 19:2907, 2018. DOI:10.3390/ijms19102907 - Jin F, Li X, Deng Y, Timilshina M, Huang B, Kim DY, Chang JH, Ichinose H, Baek SH, Murakami M, Lee YJ, Chang HW
The orphan nuclear receptor NR4A1 promotes FcepsilonRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis.
Allergy 74(6):1145-1156, 2018. DOI:10.1111/all.13702 - Okumura K, Saito M, and Wakabayashi Y.
The role of PTH in mouse skin tumorigenesis.
Integrative Cancer Science and Therapeutics 5:2, 2018. DOI:10.15761/ICST.1000271 - Kawamura Y, Yamanaka K, Poh B, Kuribayashi H, Koso H, Watanabe S
The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development.
Biochem Biophys Res Commun 503(4):3023-3030, 2018. DOI:10.1016/j.bbrc.2018.08.088 - M. Ishido*
The temporal turning window for rat behavioral phenotypes by rotenone.
Fund. Toxicol. Sci. 5, 2018. - Ihara T,Mitsui T,Nakamura Y,Kanda M,Tsuchiya S,Kira S,Nakagomi H,Sawada N,kamiyama M, Shigetomi E,Shinozaki Y,Yoshiyama M,Nakao A,Takeda M,Koizumi S.
The time-dependent variation of ATP release in mouse primary-cultured urothlial cells is regulated by the clock gene.
Neurourol Urodym. 37:2535-2543, 2018. DOI:10.1002/nau.23793 - Futakuchi M, Nitanda T, Ando S, Matsumoto H, Yoshimoto E, Fukamachi K, Suzui M
Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment.
Int J Mol Sci 19(3), 2018. DOI:10.3390/ijms19030888 - Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama S
Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells.
Scientific Reports 8:6760, 2018. DOI:10.1038/s41598-018-25189-y - Ohto, U., H. Ishida, T. Shibata, R. Sato, K. Miyake, and T. Shimizu.
Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.?.
Immunity 48(4):649-658, 2018. DOI:10.1016/j.immuni.2018.03.013 - Kurihara Y, Makita Y, Kawashima M, Fujita T, Iwasaki S, and Matsui M.
Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis.
Proc Natl Acad Sci USA 115(30):7831-7836, 2018. DOI:10.1073/pnas.1804971115 - Maeda A, Nishino T, Matsuzaki R, Yokoyama A, Suga H, Yagi T, Konishi H.
Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling.
Biochim Biophys Acta Mol Cell Res. 1866:285-295, 2018. DOI:10.1016/j.bbamcr.2018.11.009 - Momohara Y., Aonuma H. and Nagayama T.
Tyraminergic modulation of agonistic outcomes in crayfish.
J. Comp. Physiol. 204:465-473, 2018. DOI:10.1007/s00359-018-1255-3 - Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K,
Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.
UBL3 modification influences protein sorting to small extracellular vesicles.
Nature Communications 9:3936, 2018. DOI:10.1038/s41467-018-06197-y - Taiwa K, Yokoi S, Mito M2, Fujii K, Kimura Y, Iwasaki S, Nakagawa S.
UPA-Seq: Prediction of Functional LncRNAs Using Differential Sensitivity to UV Crosslinking.
RNA 24(12):1785-1802., 2018. DOI:10.1261/rna.067611.118 - Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Nameta M, Zhang L, Iwakura Y, Nawa H, Higuchi M, Komatsu M, Fujii M.
USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis.
iScience. 9:433-450, 2018. DOI:10.1016/j.isci.2018.11.006 - Shimizu A, Zankov DP, Kurokawa-Seo M, Ogita H.
Vascular endothelial growth factor-A exerts diverse cellular effects via small G proteins, Rho and Rap.
Int J Mol Sci 19:E1203, 2018. DOI:10.3390/ijms19041203 - Huizi Li, Aya Sugyo, Atsushi Tsuji, Yukie Morokoshi, Katsuyuki Minegishi, Kotaro Nagatsu, Hiroaki Kanda, Yosuke Harada, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Tatsuya Higashi, Sumitaka Hasegawa
α-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibody against frizzled homolog 10.
Cancer Science 109(7):2302-2309, 2018. DOI:10.1111/cas.13636 - Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H.
β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.
PLoS ONE 13(5):e0196946, 2018. DOI:10.1371/journal.pone.0196946 - 佐藤信吾
がん骨転移のメカニズムの新知見と創薬への可能性.
PHARM STAGE 18(3):54-58, 2018. - 佐藤信吾
がん細胞由来分泌型マイクロRNAが造骨型骨転移を惹起する.
臨床雑誌整形外科 69(11):1124, 2018. - Kojiro Ishibashi, Riku Egami, Kazuki Nakai, Shunsuke Kon
がん変異細胞が産生されたときの代謝変化に関する総説.
Cell Structure and Function 43:171-176, 2018. DOI:10.1247/csf.18018 - Vu HT, Kobayashi M, Hegazy AM, Tadokoro Y, Ueno M, Kasahara A, Takase Y, Nomura N, Peng H, Ito C, Ino Y, Todo T, Nakada M, Hirao A.
グリオーマ幹細胞の治療抵抗性におけるオートファジーの役割.
Cancer Sci 109:2497-2508, 2018. DOI:10.1111/cas.13695 - 和田裕一, 三浦知志, 窪俊一
マンガの読みにおける状況モデルの更新.
マンガ研究 24:93-114, 2018. - 外川 龍之介, 奥畑 大悟, 吉田 侑冬，中尾 光之, 片山 統裕
眼位・瞳孔径変動を考慮した内因性光信号イメージングに基づく覚醒時マウス脳視野地図の推定.
生体医工学 :in press, 2018. - Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi N, Hirao A
高脂肪食ストレスによる幹細胞制御の破綻.
Cell Stem Cell 22:713-725, 2018. DOI:10.1016/j.stem.2018.04.002 - Zhang Y, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Yamamori H, Boku S, Horai T, Someya T, Ohmori T, Hashimoto R, Sora I
高齢の統合失調症におけるより長いテロメアと、日本人の長期入院との関連.
J Psychiatr Res. 103:161-166, 2018. DOI:10.1016/j.jpsychires.2018.05.014 - Shunsuke Kon.
細胞競合の生理的、病理的な役割に関する総説.
Development, Growth and Differentiation 60:14-20, 2018. DOI:10.1111/dgd.12415 - 岡田正康, 棗田学, 河嵜麻実, 大石誠, 藤井幸彦, 五十嵐道弘
細胞突起形成抑制による膠芽腫治療戦略.
新潟県医師会報 814(1):9-10, 2018. - 古瀬 民生, 若菜 茂晴
胎児期栄養は発達障害の環境要因となりうるのか.
日本衛生学雑誌 73:97-100, 2018. DOI:10.1265/jjh.73.97 - 石堂正美
超低周波電磁界の神経幹細胞に及ぼす影響評価に関する研究.
磁気と健康 30:20-25, 2018. - Nakamura S, Koyama T, Izawa N, Nomura S, Fujita T, Omata Y, Minami T, Matsumoto M, Nakamura M, Fujita-Jimbo E, Momoi T, Miyamoto T, Aburatani H, Tanaka S
Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.
PLoS One 12(4):e0175632, 2017. DOI:10.1371/journal.pone.0175632
2017年度
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Dasatinib exacerbates splenomegaly of mice inoculated with Epstein-Barr virus-infected lymphoblastoid cell lines.
Sci Rep. 10(1):4355, 2020. - T. Yamada, A. Tanaka, T. Nehira, T. Nishii, T. Kikuchi
Altercrasins A-E, decalin derivatives, from a sea-urchin-derived Alternaria sp.: isolation and structural analysis including stereochemistry.
Marine Drugs 17:218, 2019. DOI:10.3390/md17040218 - T. Yamada, A. Fujii, T. Kikuchi
New diterpenes with a fused 6-5-6-6 ring system isolated from the marine sponge-derived fungus Trichoderma harzianum.
Marine Drugs 17:480, 2019. DOI:10.3390/md17080480 - Ito T, Oti T, Takanami K, Satoh K, Ueda Y, Sakamoto T, Sakamoto H.
A sexually dimorphic peptidergic system in the lower spinal cord controlling penile function in non-human primates.
Spinal cord 56(1):57-62, 2018. DOI:10.1038/sc.2017.105 - Yamada T, Imamachi N, Onoguchi-Mizutani R, Imamura K, Suzuki Y, Akimitsu N
5'-Bromouridine IP Chase (BRIC)-Seq to Determine RNA Half-Lives.
Methods Mol Biol 1720:1-13, 2018. DOI:10.1007/978-1-4939-7540-2_1 - Inoue D, Fujino T, Sheridan P, Zhang Yz, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata KC, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang FC, Oyama M, Kitamura T
A novel ASXL1?OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.
Leukemia 32(6):1327-1337, 2018. DOI:10.1038/s41375-018-0083-3 - Meikui Wu,Makoto Takemoto,Huan Luo,Jian-Jun Xu,Mei-Hong Lu,Masaki Kameyama,Toru Takumi,Wen-Jie Song.
A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1.
Eur J Pharmacology 824:99-107, 2018. DOI:10.1016/j.ejphar.2018.02.013 - Shinno, N., Kimura, H., Sada, R., Takiguchi, S., Mori, M., Fumoto, K., Doki, Y., and Kikuchi, A.
Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.
Oncogene 37:6107-6120, 2018. DOI:10.1038/s41388-018-0179-2 - Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y, Muto A, Okano H,?Yamanaka A, Tawfik VL, Kuzumaki N, Navratilova E, Porreca F, *Narita M.
Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer.
Molecular Pain 14:1744806918756400, 2018. DOI:10.1177/1744806918756406 - Ueno H, Takao K, Suemitsu S, Murakami S, Kitamura N, Wani K, Okamoto M, Aoki S, Ishihara T
Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex.
Neurochem Int 112:59-70, 2018. DOI:10.1016/j.neuint - Hashimoto M, Yamanaka A, Kato S, Tanifuji M, Kobayashi K, Yaginuma H.
Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus.
Frontiers in Neural Circuit 12:6, 2018. DOI:10.3389/fncir.2018.00006 - Sobue A, Ito N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K.
Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes.
Glia 66:1034-1052, 2018. DOI:10.1002/glia.23299 - Kitamura T.
ASXL1 mutations gain a function.
Blood 131(3):274-275, 2018. DOI:10.1182/blood-2017-12-816595 - Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR.
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.
EMBO J. , 2018. DOI:10.15252/embj.201797858 - Moriguchi S, Ishizuka T, Yabuki Y, Shioda N, Sasaki Y, Tagashira H, Yawo H, Yeh JZ, Sakagami H, Narahashi T, Fukunaga K.
Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy.
Mol Psychiatry. 23(2):211-221, 2018. DOI:10.1038/mp.2016.187 - Hayashida T, Saito Y, Ishii A, Yamada H, Itakura A, Minato T, Fukuyama T, Maegaki Y, Hirose S.
CACNA1A-related early-onset encephalopathy with myoclonic epilepsy: A case report.
Brain & Development 40(2):130-133, 2018. DOI:10.1016/j.braindev.2017.08.006 - Hashimoto K, Ochi H, Sunamura S, Kosaka N, Mabuchi Y, Fukuda T, Yao K, Kanda H, Ae K, Okawa A, Akazawa C, Ochiya T, Futakuchi M, Takeda S, Sato S
Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A.
Proc Natl Acad Sci U S A 115(9):2204-2209, 2018. DOI:10.1073/pnas.1717363115 -
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Cell-type specific survey of epigenetic modifications by tandem chromatin immunoprecipitation sequencing.
Scientific Reports 8:1143, 2018. DOI:10.1038/s41598-018-19494-9 - Nakamura, Y., Nakamura, K.
Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability.
Pfl?gers Archiv - European Journal of Physiology 470:823-837, 2018. DOI:10.1007/s00424-017-2090-z - Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, Nabeshima T.
Cerebellar α6 subunit-containing GABAA receptors: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders.
Br J Pharmacol. 175(12):2414-2427, 2018. DOI:10.1111/bph.14198 - Sakai E., Nakayama M., Oshima H., Kouyama Y., Niida A., Fujii S., Ochiai A., Nakayama KI., Mimori K., Suzuki Y., Hong CP., Ock CY., Kim SJ., Oshima M.
Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.
Cancer Res. 78(5):1334-1346, 2018. DOI:10.1158/0008-5472.CAN-17-3303 - Kaizuka T, Hayashi T
Comparative analysis of palmitoylation sites of serotonin (5-HT) receptors in vertebrates.
Neuropsychopharmacology Reports 38:75-85, 2018. DOI:10.1002/npr2.12011 - Hagihara H., Catts VS., Katayama Y., Shoji H., Takagi T., Huang FL., Nakao A., Mori Y., Huang KP., Ishii S., Graef IA., Nakayama KI., Shannon Weickert C., Miyakawa T.
Decreased brain pH as a shared endophenotype of psychiatric disorders.
Neuropsychopharmacology 43:459-68, 2018. DOI:10.1038/npp.2017.167 - *Fakruddin M, *Wei FY, Suzuki T, Asano K, Kaieda T, Omori A, Izumi R, Fujimura A, Kaitsuka T, Miyata K, Araki K, Oike Y, Scorrano L, Suzuki T, Tomizawa K.
Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
Cell Rep 22:482-496, 2018. - Nakayama S., Yumimoto K., Kawamura A., Nakayama KI.
Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7?in a manner dependent on the kinase GSK-3.
J. Biol. Chem. 293(15):5705-5714, 2018. DOI:10.1074/jbc.RA117.000741 - Eisuke Sato, Maho Morita, Haruo Ogawa, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Satoshi ?mura, Arihiro Iwasaki and Kiyotake Suenaga
Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ pump inhibitor from marine cyanobacteria.
Bioorganic & Medicinal Chemistry Letters 28 (3):298-301, 2018. DOI:10.1016/j.bmcl.2017.12.050 - Suda Y, Kuzumaki N, Narita M, Hamada Y, Shibasaki M, Tanaka K, Tamura H, Kawamura T, Kondo T,?Yamanaka A, *Narita M.
Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors.
Biochemical and Biophysical Research Communications? 496(4):1102-1108, 2018. DOI:10.1016/j.bbrc.2018.01.145 - Kusumoto Y, Okuyama H, Shibata T, Konno K, Takemoto Y, Maekawa D, Kononaga T, Ishii T, Akashi-Takamura S, Saitoh SI, Ikebuchi R, Moriya T, Ueda M, Miyake K, Ono S, Tomura M.
Epithelial Membrane Protein 3 (Emp3) Downregulates Induction and Function of Cytotoxic T Lymphocytes by Macrophages via TNF-α Production.
Cell Immunol. 30(2):43-51, 2018. DOI:10.1016/j.cellimm.2017.12.001 - Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, Fujii T, Kakuta S, Kubo S, Shibata T, Yamaguchi K, Iwakura Y, Furukawa Y.
Establishment and Analysis of a Novel Mouse Line Carrying a Conditional Knockin Allele of a Cancer-Specific FBXW7 Mutation.
Sci Rep. 8:2021, 2018. DOI:10.1038/s41598-018-19769-1 - Arakawa, H., & Iguchi, Y.
Ethological and multi-behavioral analysis of learning and memory performance in laboratory rodent models.
Neuroscience Research 135:1-12, 2018. DOI:10.1016/j.neures.2018.02.001 - Lucas BA, Lavi E, Shiue L, Cho H, Katzman S, Miyoshi K, Siomi MC, Carmel L, Ares M Jr, Maquat LE.
Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay.
Proc Natl Acad Sci U S A. 115:968-973, 2018. DOI:10.1073/pnas.1715531115 - Yamazaki M, Yamada H, Munetsuna E, Ishikawa H, Mizuno G, Mukuda T, Mouri A, Nabeshima T, Saito K, Suzuki K, Hashimoto S, Ohashi K.
Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter.
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Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis.
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Alternative Formation of Red-Shifted Channelrhodopsins: Noncovalent Incorporation with Retinal-Based Enamine-Type Schiff Bases and Mutated Channelopsin.
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Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.
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Association Study of MIF Promoter Polymorphisms With Suicide Completers in the Japanese Population.
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Autophagy 17:764-777, 2017. DOI:10.1080/15548627.2017.1314897 - Ishihara N, Suzuki S, Tanaka S, Watanabe Y, Nagayama D, Saiki A, Tanaka T, Tatsuno I.
Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells.
Mol Med Rep. 16(4):4756-4762, 2017. DOI:10.3892/mmr.2017.7141 - Kwon T*, Sakamoto M* (Co-first author), Peterka DS, Yuste R
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Cell Reports 20(5):1100-1110, 2017. DOI:10.1016/j.celrep.2017.07.012 - Kuma A, Komatsu M, Mizushima N.
Autophagy-monitoring and autophagy-deficient mice.
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BRAG2a, a guanine nucleotide exchange factor for Arf6, is a component of the dystrophin-associated glycoprotein complex at the photoreceptor terminal.
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C4b Binding Protein Negatively Regulates TLR1/2 Response.
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Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response.
Cancer Science 108 (9):1793-1802, 2017. DOI:10.1111/Cas.13304 - Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H
Calmodulin kinases: essential regulators in health and disease.
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CENP-R acts bilaterally as a tumor suppressor and an oncogene in the two-stage skin carcinogenesis model.
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Cerebral haemodynamic response to somatosensory stimulation in neonatal lambs.
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Challenges in the development of therapeutics for narcolepsy.
Progress in Neurobiology 152:89-113, 2017. DOI:10.1016/j.pneurobio.2015.12.002 - Urai M, Aizawa T, Imamura K, Hamamoto H, Sekimizu K
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CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations.
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Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice.
Frontiers in Behavioral Neuroscience 11:125, 2017. DOI:10.3389/fnbeh - Hayashi T
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Neurotransmitter 4:e1608, 2017. DOI:10.14800/nt.1608 - Watanabe T, Shimazaki T, Oda Y.
Coordinated expression of two types of low-threshold K+ channels establishes unique single-spiking of Mauthner cells among segmentally homologous neurons in the zebrafish hindbrain.
eNeuro 1523:0249-17, 2017. DOI:10.1523/ENEURO.0249-17.2017 - Fukutomi, M. and Ogawa, H.
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DEclust: A statistical approach for obtaining differential expression profiles of multiple conditions.
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The Journal of Experiment Medicine 214(5):1431-1452, 2017. DOI:10.1084/jem - Takano, T., Motozono, C*., Imai, T., Sonoda, KH., Nakanishi, Y., Yamasaki, S*.
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Depletion of Myeloid Cells Exacerbates Hepatitis and Induces an Aberrant Increase in Histone H3 in Mouse Serum.
Hepatology 65(1):237-252, 2017. DOI:10.1002/hep.28878 - Tsutomu Fukuda, Teppei Umeki, Keiji Tokushima, Gao Xiang, Yuki Yoshida, Fumito Ishibashi, Yusuke Oku, Naoyuki Nishiya, Yoshimasa Uehara, Masatomo Iwao
Design, synthesis, and evaluation of A-ring-modified lamellarin N analogues as noncovalent inhibitors of the EGFR T790M/L858R mutant.
Bioorganic and Medicinal Chemistry 25 (24):6563-6580, 2017. DOI:10.1016/j.bmc.2017.10.030 - Syuji Kurogi, Tomohisa Sekimoto, Taro Funamoto, Tomomi Ota, Shihoko Nakamura, Takuya Nagai, Mai Nakahara, Kumiko Yoshinobu, Kimi Araki, Masatake Araki and Etsuo Chosa
Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
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Biol Open. 15:1041-1055, 2017. DOI:10.1242/bio.025999 - Kikuchi A., Fumoto K., Kimura H.
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Br. J. Pharmacol 174(24):4651-4665, 2017. DOI:10.1111/bph.13863 - Okubo T, Sato A, Okamoto H, Sato T, Sasaoka T
Differential behavioral phenotypes of dopamine D1 receptor knockdown mice at the embryonic, postnatal, and adult stages.
International Journal of Developmental Neuroscience 66:1-8, 2017. DOI:10.1016/j.ijdevneu.2017.11.004 - Zankov DP, Sato A, Shimizu A, Ogita H.
Differential effects of myocardial afadin on pressure overload-induced compensated cardiac hypertrophy.
Circ J 81:1862-1870, 2017. DOI:10.1253/circj.CJ-17-0394 - Jiang F-X, Li K, Archer M, Mehta M, Jamieson E, Charles A, Dickinson JE, Matsumoto M, Morahan G
Differentiation of Islet Progenitors Regulated by Nicotinamide into Transcriptome-verified β Cells that Ameliorate Diabetes.
Stem Cells 35:1341-1354, 2017. DOI:10.1002/stem.2567 - Yasuda D, Yuasa A, Obata R, Nakajima M, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.
Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor.
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Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection.
Frontiers in Neuroanatomy 0.504166666666667, 2017. DOI:10.3389/fnana.2017.00066 - Soma S, Saiki A, Yoshida J, R?os A, Kawabata M, Sakai Y, Isomura Y
Distinct laterality in forelimb-movement representations of rat primary and secondary motor cortical neurons with intratelencephalic and pyramidal tract projections.
The Journal of Neuroscience 37(45):10904-10916, 2017. DOI:10.1523/JNEUROSCI.1188-17.2017 - M. Ishido*, R.Usu
Distinct regulation of nuclear localization of caspase-activated DNase during cadmium-induced apoptosis of the target cells.
Fund. Toxicol. Sci. 4:159-165, 2017. DOI:10.2131/fts.4.159 - Ide S, Takahashi T, Takamatsu Y, Uhl GR, Niki H, Sora I, Ikeda K.
Distinct Roles of Opioid and Dopamine Systems in Lateral Hypothalamic Intracranial Self-Stimulation.
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Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells.
J. Biol. Chem 292(29):12054-12064, 2017. DOI:10.1074/jbc.M117.790568 - Yamaguchi N, Nakayama Y, Yamaguchi N
Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6.
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Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation.
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Dysfunctional GPR40/FFAR1 Signaling Exacerbates Pain Behavior in Mice.
PLoS One 12(7):e0180610, 2017. DOI:10.1371/journal.pone.0180610 - Yuichiro Yoneoka, Masayasu Okada, Naoto Watanabe, Satoru Aoki, Akiyoshi Kakita, Yukihiko Fujii
Ectopic pituitary null cell adenoma arising from the infundibulum in the third ventricle: A successful endonasal transsphenoidal resection after long-term follow-up MR imaging ? A technical note.
Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 10:122-125, 2017. DOI:10.1016/j.inat.2017.08.004 - Masatsugu Ohgami, Nobuhiko Takai , Masahiko Watanabe, Koichi Ando, Akiko Uzawa, Ryoichi Hirayama
EFFECT OF N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST ON RADIATION-INDUCED GUT INJURIES IN MICE.
RadProc vol.2, 2017. DOI:10.21175 - Ohta Y, Kubo H, Yashiro K, Ohashi K, Tsuzuki Y, Wada N, Yamamoto Y, Saito K.
Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues.
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Elaidic acid, a trans fatty acid, enhances the metastasis of colorectal cancer cells.
Pathobiology 84(3):144-151, 2017. DOI:10.1159/000449205 - Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabe M, Sasahara M, Fukunaga K
Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons.
Molecular Psychiatry 22 (8):1205-1222, 2017. DOI:10.1038/mp.2016.200 - Hattori M, Shimizu A, Oikawa D, Kamei K, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Tokunaga F, Ishikawa O.
Endoplasmic reticulum stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa.
British Journal of Dermatology 177(4):e92-e93, 2017. DOI:10.1111/bjd.15342 - Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama, Kentaro semba, Takuya Tomita, Shigeo Murata, Hiroyuki Arai and Tomohiko Taguchi
Endosomal phosphatdylserine is critical for the YAP signaling pathway in proliferating cells.
Nature Communications 8:1246, 2017. DOI:10.1038/s41467-017-01255-3 - Goswami, D., Marz, S., Li, Y. T., Artz, A., Schafer, K., Seelige, R., Pacheco-Blanco, M., Jing, D., Bixel, M. G., Araki, M., Araki, K., Yamamura, K., Vestweber, D.
Endothelial CD99 supports arrest of mouse neutrophils in venules and binds to neutrophil PILRs.
Blood 129(13):1811-1822, 2017. DOI:10.1182/blood-2016-08-733394 - Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N
Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).
Biochem Biophys Res Commun. 490(3):1045-1051, 2017. DOI:10.1016/j.bbrc.2017.06.163 - Goyama S and Kitamura T.
Epigenetics in Normal and Malignant Hematopoiesis: An Overview and Update 2017.
Cancer Sci. 108(4):553-562, 2017. DOI:10.1111/cas.13168 - Shinohara K., Watabe, A.M. # , Nagase M., Okutsu Y., Takahashi Y., Kurihara H., Kato F.(#責任著者)
Essential Role of Endogenous Calcitonin Gene-Related Peptide in Pain-associated Plasticity in the Central Amygdala.
European Journal of Neuroscience 46(6):2149-2160, 2017. DOI:10.1111/ejn.13662 - Muto Y., Nishiyama M., Nita A., Moroishi T., Nakayama KI.
Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
Nature Commun. 8:16114, 2017. DOI:10.1038/ncomms16114 - Kondo A & Osawa T
Establishment of an extracellular acidic pH culture system.
JoVE 129:e56660, 2017. - Itoh M, Kaizuka T, Hayashi T
Evolutionary acquisition and divergence of vertebrate HCN2 palmitoylation.
Neurotransmitter 4:e1603, 2017. DOI:10.14800/nt.1603 - Yanase T, Matsumoto M, Tanaka T, Mera T, Yasunami Y, Daibo K
Expansion of transplanted islets in mice by co-transplantation with adipose tissue-derived mesenchymal stem cells.
Heliyon :e00632, 2017. DOI:10.1016/j.heliyon.2018.e00632 - Huang M, Narita S, Inoue T, Koizumi A, Saito M, Tsuruta H, Numakura K, Satoh S, Nanjo H, Sasaki T, Habuchi T
Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production.
Oncotarget 8(67):111780-111794, 2017. DOI:10.18632/oncotarget.22908 - Kawahara I, Mori T, Goto K, Fujii K, Ohmori H, Fujiwara-Tani R, Kuniyasu H
Fatty acids induce stemness in the stromal cells of a CT26 mouse tumor model.
Pathobiology 84(5):237-242, 2017. DOI:10.1159/000471854 - Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Fujiwara R, Kadochi Y, Mori S, Kuniyasu H
Fatty acids inhibit anti-cancer effect of 5-fluorouracil in mouse cancer cell lines.
Oncology Letters 14(1):681-686, 2017. DOI:10.3892/ol.2017.6190 - Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon S, Fulda S, Gascon S, Hatzios SK, Kagan V, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat G, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti F, Torti S, Toyokuni S, Woerpel KA, Zhang DD.
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease.
Cell 171:273-285, 2017. DOI:10.1016/j.cell.2017.09.021 - Suzuki-Kerr H, Baba Y, Tsuhako A, Koso H, Dekker JD, Tucker H, Kuribayashi H, Watanabe S.
Forkhead box protein P1 is essential for lens epithelium transition to the fiber cells during development but does not play roles for retinal development.
Invest. Ophthalmol. Vis. Sci. 58:1916-1929, 2017. DOI:10.1167/iovs.16-20085 - Anzai E, Hirata K, Shibazaki M, Yamada C, Morii M, Honda T, Yamaguchi N, Yamaguchi N
FOXA1 Induces E-Cadherin Expression at the Protein Level via Suppression of Slug in Epithelial Breast Cancer Cells.
Biol Pharm Bull. 40(9):1483-1489, 2017. DOI:10.1248/bpb.b17-00307 - Saito K, Ohta S, Kawakami Y, Yoshida K, Toda M
Functional analysis of KIF20A, a potential immunotherapeutic target for glioma.
J Neurooncol 132(1):63-74, 2017. DOI:10.1007/s11060-016-2360-1 - Tsunoda SP, Prigge M, Abe-Yoshizumi R, Inoue K, Kozaki Y, Ishizuka T, Yawo H, Yizhar O, Kandori H.
Functional characterization of sodium-pumping rhodopsins with different pumping properties.
PLoS One. 12(7):e0179232, 2017. DOI:10.1371/journal.pone.0179232 - Ali MAE， Fuse K， Tadokoro Y， Hoshii T， Ueno M， Kobayashi M， Nomura N， Vu HT， Peng H， Hegazy AM， Masuko M， Sone H， Arai F， Tajima A， Hirao A.
Functional Dissection of Hematopoietic Stem Cell Populations With a Stemness-Monitoring System Based on NS-GFP Transgene Expression.
Scientific Report 7:11442, 2017. DOI:10.1038/s41598-017-11909-3 - Sato M, Kokabu S, Enoki Y, Hayashi N, Matsumoto M, Nakahira M, Sugasawa M, Yoda T
Functional roles of netrin-1 in osteoblast differentiation.
In vivo 31(3):321-8, 2017. - Ostrovidov S, Ebrahimi M, Bae H, Nguyen HK, Salehi S, Kim SB, Kumatani A, Matsue T, Shi X, Nakajima K, Hidema S, Osanai M, Khademhosseini A
Gelatin-Polyaniline Composite Nanofibers Enhanced Excitation-Contraction Coupling System Maturation in Myotubes.
ACS Applied Materials & Interfaces 9(49):42444-42458, 2017. DOI:10.1021/acsami.7b03979 - Nishihara S
Glycans define the stemness of na?ve and primed pluripotent stem cells.
Glycoconj J. 34(6):737-747, 2017. DOI:10.1007/s10719-016-9740-9 - Okamoto A, Morinaga T, Yamaguchi N, Yamaguchi N
Golgi Distribution of Lyn to Caveolin- and Giantin-Positive cis-Golgi Membranes and the Caveolin-Negative, TGN46-Positive trans-Golgi Network.
Biol Pharm Bull.? 41(1):142-146, 2017. DOI:10.1248/bpb.b17-00681 - Shuji Wakatsuki, Shinji Tokunaga, Megumi Shibata,Toshiyuki Araki
GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration.
J Cell Biology 216:477, 493, 2017. DOI:10.1083/jcb.201606020 - Hasumi H, Hasumi Y, Baba M, Nishi H, Furuya M, Vocke CD, Warner AC, Haines DC, Wei MH, Zbar B, Yao M, Metwalli AR, Marston Linehan W, Schmidt LS.
H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.
Human Molecular Genetics 26(2):354-366, 2017. DOI:10.1093/hmg/ddw392 - Hideko Ohno, Yuichiro Yoneoka, Shinya Jinguji, Naoto Watanabe, Masayasu Okada, Yukihiko Fujii
Has acromegaly been diagnosed earlier?.
Journal of Clinical Neuroscience 48:138-142, 2017. DOI:10.1016/j.jocn.2017.10.086 - Zhang S., Chen Q., Liu Q., Li Y., Sun X., Hong L., Ji S., Liu C., Geng J., Zhang W., Lu Z., Yin ZY., Zeng Y., Lin KH., Wu Q., Li Q., Nakayama K., Nakayama KI., Deng X., Johnson RL., Zhu L., Gao D., Chen L., Zhou D.
Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2.
Cancer Cell 31:669-84, 2017. DOI:10.1016/j.ccell.2017.04.004 - M. Ishido*, R.Usu
HSP70-Ran-RCC1 transport system during cadmium-induced apoptosis in porcine kidney LLC-PK1 cells.
Fund. Toxicol. Sci. 4:187-189, 2017. DOI:10.2131/fts.4.187 - Goto A, Yoshimi A, Nagai T, Ukigai M, Mouri A, Ozaki N, Noda Y.
Human neutrophils show decreased survival upon long-term exposure to clozapine.
Hum Psychopharmacol. 32:e2629, 2017. DOI:10.1002/hup.2629 - Ono D, Yamanaka A
Hypothalamic regulation of the sleep/wake cycle.
Neuroscience Research 118:74-81, 2017. DOI:10.1016/j.neures.2017.03.013 - Sato Y, Tsuyama T, Sato C, Karim MF, Yoshizawa T, Inoue M, Yamagata K
Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase.
J Biol. Chem. 292:8716-8728, 2017. DOI:10.1074/jbc.M116.767574 - Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A.
Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.
Leukemia 31(4):861-871, 2017. DOI:10.1038/leu.2016.268 - Tsukada M, Ota Y, Wilkinson AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S.
In?Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma.
Stem Cell Reports. 9(4):1024-1033, 2017. DOI:10.1016/j.stemcr.2017.08.010 - Kimura A, Takemura M, Saito K, Serrero G, Yoshikura N, Hayashi Y, Inuzuka T.
Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder.
J Neuroimmunol. 305:175-181, 2017. DOI:10.1016/j.jneuroim.2017.01.006 - DiRienzo, N. and Aonuma H.
Individual differences are consistent across changes in mating status and mediated by biogenic amine.
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Iron and thiol redox signaling in cancer.
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Cell & Tissue Research 370(3):441-449, 2017. DOI:10.1007/s00441-017-2674-0 - Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
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The Journal of Physiology 595(1):385-413, 2017. DOI:10.1113/JP272794 - Yamashita T, *Yamanaka A
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Current Opinion in Neurobiology 44:94-100, 2017. DOI:10.1016/j.conb.2017.03.020 - Yamamoto, H., Umeda, D., Matsumoto, S., and Kikuchi, A.
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Sci Rep. 7, 2017. DOI:10.1038/s41598-017-15305-9 - Kondo A, Nonaka A, Shimamura T, Yamamoto S, Yoshida T, Kodama T, Aburatani H and Osawa T
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Cell Rep. 21:3637-3645, 2017. DOI:10.1016/j.celrep.2017.11.109 - Hanaki, Y., Kikumori, M., Tokuda, H., Okamura, M., Dan, S., Adachi, N., Saito, N., Yanagita, R. C., Irie, K.
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Molecules 22(4):e631, 2017. DOI:10.3390/molecules22040631 - Hashimotodani, Y., Nasrallah, K., Jensen, K.R., Chavez, A.E., Carrera, D., and Castillo, P.E.
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Neuron 95:928-943, 2017. DOI:10.1016/j.neuron.2017.07.028 - Iizuka-Hishikawa Y, Hishikawa D, Sasaki J, Takubo K, Goto M, Nagata K, Nakanishi H, Shindou H, Okamura T, Ito C, Toshimori K, Sasaki T, Shimizu T.
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J Biol Chem. 292:12065-12076, 2017. DOI:10.1074/jbc.M117.791277 - Fuse MJ, Okada K, Oh-hara T, Ogura H, Fujita N, *Katayama R.
Mechanisms of resistance to NTRK inhibitors and therapeutic strategies in NTRK1-rearranged cancers.
Molecular Cancer Therapeutics 16:2130-2143, 2017. DOI:10.1158/1535-7163.MCT-16-0909 - Yamamoto K, Mak TW
Mechanistic aspects of mammalian cell size control.
Development Growth and Differentiation 59(1):33-40, 2017. DOI:10.1111/dgd.12334 - Yamamoto S., Hagihara T., Horiuchi H., Okui A., Wani S., Yoshida T., Inoue T., Tanaka A., Ito T., Hirose Y., and Ohkuma Y.
Mediator Cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.
Genes to Cells 22(3):265-276, 2017. DOI:10.1111/gtc.12475 - Yoshida A, Kitajima S, Li F, Cheng C, Takegami Y, Kohno S, Wan YS, Hayashi N, Muranaka H, Nishimoto Y, Nagatani N, Nishiuchi T, Thai TC, Suzuki S, Nakao S, Tanaka T, Hirose O, Barbie DA, Takahashi C.
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Oncotarget 8(8):13872-13885, 2017. DOI:10.18632/oncotarget.14681 - Tanaka K, Kim SE, Yano H, Matsumoto G, Ohuchida R, Ishikura Y, Araki M, Araki K, Park S, Komatsu T, Hayashi H, Ikematsu K, Tanaka K, Hirano A, Martin P, Shimokawa I, Mori R
MiR-142 Is Required for Staphylococcus aureus Clearance at Skin Wound Sites via Small GTPase-Mediated Regulation of the Neutrophil Actin Cytoskeleton.
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Mitochondrial uncoupler exerts a synthetic lethal effect against beta-catenin mutant tumor cells.
Cancer Science 108:772-784, 2017. DOI:10.1111/cas.13172 - Fumoto, K., Takigawa-Imamura, H., Sumiyama, K., Kaneiwa, T., and Kikuchi, A.
Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition.
Development 144:151-162, 2017. DOI:10.1242/dev.141325 - Mashima T, Taneda Y, Jang MK, Mizutani A, Muramatsu Y, Yoshida H, Sato A, Tanaka N, Sugimoto Y, Seimiya H.
mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer.
Oncotarget 8(29):47902-47915, 2017. DOI:10.18632/oncotarget.18146 - Sashida G, Iwama A.
Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies.
Int J Hematol 105(1):23-30, 2017. DOI:10.1007/s12185-016-2124-x - Takiguchi T, Koide H, Nagano H, Nakayama A, Fujimoto M, Tamura A, Komai E, Shiga A, Kono T, Higuchi S, Sakuma I, Hashimoto N, Suzuki S, Miyabayashi Y, Ishiwatari N, Horiguchi K, Nakatani Y, Yokote K, Tanaka T.
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
BMC Endocr Disord. 17(1):54-61, 2017. DOI:10.1186/s12902-017-0203-5 - Umeda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, Tomiyama T
Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.
Acta Neuropathol Commun 31:5(1):59, 2017. DOI:10.1186/s40478-017-0461-5 - Asano T, Ishizuka T, Yawo H.
Myogenic Maturation by Optical-Training in Cultured Skeletal Muscle Cells.
Methods Mol Biol. 1668:135-145, 2017. DOI:10.1007/978-1-4939-7283-8_10 - M. Ishido*, J. Suzuki, Y. Masuo
Neonatal rotenone lesions cause onset hyperactivity during juvenile and adulthood in the rat.
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Netrin-4 Promotes Differentiation and Migration of Osteoblasts.
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Neurocognitive Profile of Euthymic Japanese Patients With Bipolar Disorder.
Psychiatry Clin Neurosci. 71(6):373-382, 2017. DOI:10.1111/pcn.12500 - Yuji Sato, Satoko Suzuki, Yoko Iijima, and Takatoshi Iijima.
Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of Neurexin in cerebellar cultures.
Biochemical and Biophysical Research Communications. 493:1030-1036, 2017. DOI:10.1038/s41598-017-11319-5 - Nakatsumi H., Matsumoto M., Nakayama KI.
Noncanonical pathway for regulation of CCL2 expression by an mTORC1-FOXK1 axis promotes recruitment of tumor-associated macrophages.
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NOTCH2 Hajdu-Cheney mutations escape SCFFBW7-dependent proteolysis to promote osteoporosis.
Mol. Cell 68:645-58.e5, 2017. DOI:10.1016/j.molcel.2017.10.018 - Kim TS, Shin YH, Lee HM, Kim JK, Choe JH, Jang JC, Um S, Jin HS, Komatsu M, Cha GH, Chae HJ, Oh DC, Jo EK.
Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway.
Sci Rep. 7, 2017. DOI:10.1038/s41598-017-03477-3 - Yamaki N, Hishimoto A, Otsuka I, Sasada T, Boku S, Saito T, Yasuda Y, Yamamori H, Ikeda M, Sora I, Iwata N, Hashimoto R
Optimizing Outcomes in Clozapine Rechallenge Following Neutropenia Using Human Leukocyte Antigen Typing: A Case Report.
Psychiatry Clin Neurosci 71(4):289-290, 2017. DOI:10.1111/pcn.12505 - Ozaki M, Sano H, Sato S, Ogura M, Mushiake H, Chiken S, Nakano N, Nambu A
Optogenetic activation of the sensorimotor cortex reveals “local inhibitory and global excitatory” inputs to the basal ganglia.
Cerebral cortex 27:5716-5726, 2017. DOI:10.1093/cercor/bhx234 - Abe K, Yawo H.
Optogenetic conditioning of paradigm and pattern discrimination in the rat somatosensory system.
PLoS One 12(12):e0189439, 2017. DOI:10.1371/journal.pone.0189439 - Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, *Mendelowitz D
Optogenetic identification of hypothalamic orexin neuron projections to paraventricular spinally projecting neurons.
American journal of physiology. Heart and circulatory physiology 312(4):H808-H817, 2017. DOI:10.1152/ajpheart.00572.2016 - M. Ishido*, R.Usu
Orally administered p-nitrotoluene causes hyperactivity, concomitant with gliosis and impairment of tyrosine hydroxylase immunoreactivity in the rat substantia nigra.
Fund. Toxicol. Sci. 4:151-158, 2017. DOI:10.2131/fts.4.151 - Mukai S, Oue N, Oshima T, Imai T, Sekino Y, Honma R, Sakamoto N, Sentani K, Kuniyasu H, Egi H, Tanabe K, Yoshida K, Ohdan H, Yasui W
Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer.
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Overlapping memory trace indispensable for linking, but not recalling, individual memories.
Science 355(6323):398-403, 2017. DOI:10.1126/science.aal2690 - Nasanbuyan N, Yoshida M, Takayanagi Y, Inutsuka A, Nishimori K, Yamanaka A, *Onaka T.
Oxytocin-Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice.
Endocrinology. 159(2)::763-775, 2017. DOI:10.1210/en.2017-00606 - Nakamura K, Ding L
Parsing Heterogeneous Striatal Activity.
Frontiers in neuroanatomy 0.488194444444444, 2017. DOI:10.3389/fnana.2017.00043 - Sato A, Ogita H.
Pathophysiological Implications of Dipeptidyl Peptidases.
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Perifocal Inflammatory Reaction with Volume Fluctuation Caused by Diagnostic Radiation-Induced Reduction in Germinoma Makes Histological Diagnosis Difficult despite Its Disappearance following Treatment: A Significant Pitfall and Countermeasures to It.
Pediatr Neurosurg. 52:87-92, 2017. DOI:10.1159/000450583 - Naoaki Sakata, Yohko Yamaguchi, Yu Chen, Masayuki Shimoda, Gumpei Yoshimatsu, Michiaki Unno, Shoichiro Sumi, Rieko Ohki.
Pleckstrin homology-like domain family A, member 3 (PHLDA3) deficiency improves islets engraftment through the suppression of hypoxic damage.
PLoS One 12(11):e0187927, 2017. DOI:10.1371/journal.pone.0187927 - Sato N, Shidara H, Ogawa H.
Post-molting development of wind-elicited escape behavior in the cricket.
J Insect Physiol. 103:36-46, 2017. DOI:10.1016/j.jinsphys.2017.10.003 - Fujii K, Luo Y, Nishiguchi Y, Fujiwara R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H
Pro-metastatic intracellular signaling of elaidic acid, a trans fatty acid.
Int J Oncol 50(1):85-92, 2017. DOI:10.3892/ijo.2016.3797 - Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A
Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory-functions and neurogenesis.
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Proton pump inhibitor induces-collagen expression in colonocytes is associated with collagenous colitis.
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Proviral Features of Human T Cell Leukemia Virus Type 1 in Carriers with Indeterminate Western Blot Analysis Results.
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PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.
Mol Cell 68(3):566-580, 2017. DOI:10.1016/j.molcel.2017.09.024 - Koike M, Shibata M, Sunabori T, Yamaguchi J, Sakimura K, Komatsu M, Tanaka K, Uchiyama Y.
Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.
Am J Pathol. 187:1586-1600, 2017. DOI:10.1016/j.ajpath.2017.02.020 - Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Inoue E, Igeta H, Otsuka I, Shibuya M, Egawa J, Sora I, Someya T.
Rare FBXO18 Variations and Risk of Schizophrenia: Whole-exome Sequencing in Two Parent-Affected Offspring Trios Followed by Resequencing and Case-Control Studies.
Psychiatry Clin Neurosci. 71(8):562-568, 2017. DOI:10.1111/pcn.12526. - Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Kaneko N, Muratake T, Shinmyo N, Otsuka I, Okuda S, Inoue E, Igeta H, Shibuya M, Egawa J, Orime N, Sora I, Someya T.
Rare PDCD11 Variations Are Not Associated With Risk of Schizophrenia in Japan.
Psychiatry Clin Neurosci 71(11):780-788, 2017. DOI:10.1111/pcn.12549 - Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.
Nucleic Acids Res. 45:435-445, 2017. DOI:10.1093/nar/gkw745 - Moriguchi S, Kita S, Fukaya M, Osanai M, Inagaki R, Sasaki Y, Izumi H, Horie K, Takeda J, Saito T, Sakagami H, Saido TC, Iwamoto T, Fukunaga K
Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.
Neuropharmacology 131:291-303, 2017. DOI:10.1016/j.neuropharm.2017.12.037 - Fukai Y, Ohsawa Y, Ohtsubo H, Nishimatsu S, Hagiwara H, Noda M, Sasaoka T, Murakami T, Sunada Y
Redundancy of matrix metalloproteinases cleaving beta-dystroglycan: Implications for the pathogenesis of sarcoglycanopathy.
Biochemical Biophysical Research Communications 492 (2):199-205, 2017. DOI:10.1016/j.bbrc.2017.08.048 - Katow H, Kanaya T, Ogawa T, Egawa R, Yawo H.
Regulation of axon arborization pattern in the developing chick ciliary ganglion: Possible involvement of caspase 3.
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Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed proliferation of CT26 mouse colon cancer cells.
Oncology Letters 14(1):673-680, 2017. DOI:10.3892/ol.2017.6195 - *Tamada A, Igarashi M
Revealing chiral cell motility by 3D Riesz transform-differential interference contrast microscopy and computational kinematic analysis.
Nature Communications 8:2194ｰ, 2017. DOI:10.1038/s41467-017-02193-w - Kuroda N, Ohe C, Kato I, Furuya M, Baba M, Nagashima Y, Nakatani Y, Murakami I, Zhou M, Michal M, He O, Amin MB
Review of hereditary leiomyomatosis renal cell carcinoma with focus on clinical and pathobiological aspects of renal tumors.
Polish Journal of Pathology 68(4):284-296, 2017. DOI:10.5114/pjp.2017.73920 - Ito S, Koso H, Sakamoto K, Watanabe S
RNA helicase DHX15 acts as a tumour suppressor in glioma.
Br. J. Cancer 117(9):1349-1359, 2017. DOI:10.1038/bjc.2017.273 - K Nakayama, R Ohashi, Y Shinoda, M Yamazaki, M Abe, A Fujikawa, S Shigenobu, A Futatsugi, M Noda, K Mikoshiba, T Furuichi, K Sakimura, and N Shiina
RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation.
eLife 6:e29677, 2017. DOI:10.7554/eLife.29677 - Yachie N., Robotic Biology Consortium (incl. Nakayama KI.), Natsume T.
Robotic crowd biology with Maholo LabDroids.
Nature Biotechnol. 35:310-2, 2017. DOI:10.1038/nbt.3758 - Honda A, Usui H, Sakimura K, *Igarashi M
Rufy3 is an adapter protein for small GTPases that activates a Rac guanine nucleotide exchange factor to control neuronal polarity.
J Biol Chem 292:20936-20946, 2017. DOI:10.1074/jbc.M117.809541 - Wang CQ, Mok MM, Yokomizo T, Tergaonkar V, Osato M.
Runx Family Genes in Tissue Stem Cell Dynamics.
Adv Exp Med Biol 962(-):117-138, 2017. DOI:10.1007/978-981-10-3233-2_9 - Selvarajan V, Osato M, Nah GSS, Yan J, Chung TH, Voon DC, Ito Y, Ham MF, Salto-Tellez M, Shimizu N, Choo SN, Fan S, Chng WJ, Ng SB.
RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC.
Leukemia 31(10):2219-2227, 2017. DOI:10.1038/leu.2017.40 - T. Watanabe, Y. Mutoh, S. Saito
Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylanilides: Synthesis of 3-Substituted Indoles by 1,2-Carbon Migration.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139:7749-7752, 2017. DOI:10.1021/jacs.7b04564 - Kubo H, Hoshi M, Matsumoto T, Irie M, Oura S, Tsutsumi H, Hata Y, Yamamoto Y, Saito K.
Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice.
Lipids Health Dis. 16:106, 2017. DOI:10.1186/s12944-017-0501-y - Sumi-Ichinose C, Suganuma Y, Kano T, Ihira N, Nomura H, Ikemoto K, Hata T, Katoh S, Ichinose H, Kondo K
Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia.
Physiol Rep 5:e13196, 2017. DOI:10.14814/phy2.13196 - Shibata Y, Hara T, Matsumoto T, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Goto N, Nannya Y, Ito H, Kito Y, Miyazaki T, Takeuchi T, Saito K, Seishima M, Takami T, Moriwaki H, Shimizu M, Tsurumi H.
Serum concentrations of l-kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified.
Hematol Oncol 35:637-644, 2017. DOI:10.1002/hon.2318 - Kiyokawa H, Yasuda H, Oikawa R, Okuse C, Matsumoto N, Ikeda H, Watanabe T, Yamamoto H, Itoh F, Otsubo T, Yoshimura T, Yoshida E, Nakagawa M, Koshikawa N & Seiki M
Serum monomeric laminin-gamma2 as a novel biomarker for hepatocellular carcinoma.
Cancer Science 108:1432-1439, 2017. DOI:10.1111/cas.13261 - Nagano H, Nakagawa Y, Ishikawa N, Watanabe Y, Miyabayashi Y, Nakayama A, Fujimoto M, Komai E, Shiga A, Tamura A, Kono T, Takiguchi T, Higuchi S, Sakuma I, Hashimoto N, Suzuki S, Koide H, Yokote K, Tanaka T.
SEVEN FAMILIAL DYSALBUMINEMIC HYPERTHYROXINEMIA CASES IN THREE UNRELATED JAPANESE FAMILIES AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ANALYSIS OF THE THYROXINE BINDING PROFILE.
Endocr Pract 23(11):1325-1332, 2017. DOI:10.4158/EP171964.OR - Yaguchi H., Yabe I., Takahashi H., Watanabe M., Nomura T., Kano T., Matsumoto M., Nakayama KI., Watanabe M., Hatakeyama S.
Sez6l2 regulates phosphorylation of ADD and neuritogenesis.
Biochem. Biophys. Res. Commun. 494:234-41, 2017. DOI:10.1016/j.bbrc.2017.10.047 - Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K
SIRT7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Biochem Biophys Res Commun 490:423-428, 2017. DOI:10.1016/j.bbrc.2017.06.057 - Satoko Suzuki, Noriko Ayukawa, Chisa Okada, Masami Tanaka, Susumu Takekoshi, Yoko Iijima, and Takatoshi Iijima.
Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons.
Scientific Reports 7:11405, 2017. DOI:10.1038/s41598-017-11319-5 - Higuchi T, Ishizaki Y, Noritake A, Yanagimoto Y, Kobayashi H, Nakamura K, Kaneko K.
Spatiotemporal characteristics of gaze of children with autism spectrum disorders while looking at classroom scenes.
PLoS ONE 12(5), 2017. DOI:10.1371/journal.pone.0175912 - Shuji Wakatsuki, Toshiyuki Araki
Specific phospholipid scramblases are involved in exposure of phosphatidylserine, an "eat-me" signal for phagocytes, on degenerating axons.
Commun Integr Biol 17:e1296615, 2017. DOI:10.1080/19420889.2017.1296615 - Ryo Watanabe, Haruki Mizoguchi, Hideaki, Oikawa, Hirofumi Ohashi, Koichi Watashi, HirokiOguri
Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents.
Bioorg. Med. Chem. 25(11):2851-2855, 2017. DOI:10.1016/j.bmc.2017.03.011 - Kimiko Shimizu and Yoshitaka Fukada
Stereotaxic Surgery for Suprachiasmatic Nucleus Lesions in Mice.
Bio-protocol 7:2346, 2017. DOI:10.21769/BioProtoc.2346 - Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H
Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor.
Neuroscience Letters 654:99-106, 2017. DOI:10.1016/j.neulet.2017.06.005 - Yonehara R., Nada S., Nakai T., Nakai M., Kitamura A., Ogawa A., Nakatsumi H., Nakayama KI., Li S., Standley DM., Yamashita E., Nakagawa A., Okada M.
Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nature Commun. 8:1625, 2017. DOI:10.1038/s41467-017-01762-3 - K. Ito, Y. Mutoh, S. Saito
Synthesis of [2]Catenanes by Intramolecular Sonogashira-Type Reaction.
JOURNAL OF ORGANIC CHEMISTRY 82:6188-6124, 2017. DOI:10.1021/acs.joc.7b00672 - Yamazaki, Y.; Mutoh, Y.; Saito, S.
Synthesis of Interlocked Compounds by Utilizing Bond-forming Reactions Mediated by Macrocyclic Phenanthroline-Cu Complexes.
CHEMISTRY LETTERS 46:904-912, 2017. DOI:10.1246/cl.170031 - Y. Mochizuki, K. Ikeyatsu, Y. Mutoh, S. Hosoya, S. Saito
Synthesis of Mechanically Planar Chiral rac-[2]Rotaxanes by Partitioning of an Achiral [2]Rotaxane: Stereoinversion Induced by Shuttling.
ORGANIC LETTERS 19:4347-4350, 2017. DOI:10.1021/acs.orglett.7b02043 - Nakamura T, Okabe S, Yoshida H, Iida K, Ma Y, Sasaki S, Yamori T, Shin-Ya K, Nakano I, Nagasawa K, Seimiya H.
Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole.
Scientific Reports 7:e3605, 2017. DOI:10.1038/s41598-017-03785-8 - Aizawa F, Ogaki Y, Kyoya N, Nakamoto K, Kurihara T, Hirasawa A, Miyata A, Tokuyama S,
The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice.
Biol Pharm Bull 40:1255-1259, 2017. DOI:10.1248/bpb.b17-00082 - Park S, Mori R, Shimokawa I
The fat regulator neuropeptide Y and caloric restriction.
Aging (Albany NY) 9(11):2243-2244, 2017. DOI:10.18632/aging.101338 - Nobuhiko Takai, Masatsugu Ohgami, Koichi Ando, Akiko Uzawa, Ryoichi Hirayama, Saori Nakamura, Yoshihito Ohba
THE FOCAL BRAIN IRRADIATION OF PROTON BEAM INSULT IN RATS INDUCED MEMORY DISTURBANCE RELATED CHANGE IN ACETYLCHOLINE RECEPTOR BINDING.
RadProc vol.2:25-29, 2017. DOI:10.21175 - Mouri A, Noda Y, Niwa M, Matsumoto Y, Mamiya T, Nitta A, Yamada K, Furukawa S, Iwamura T, Nabeshima T.
The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization.
Behav Brain Res. 329:157-165, 2017. DOI:10.1016/j.bbr.2017.04.052 - Yahiro, T., Kataoka, N., Nakamura, Y., Nakamura, K.
The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation.
Scientific Reports 7:5031, 2017. DOI:10.1038/s41598-017-05327-8 - Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I, Wakana S, Yamaguchi M, Shitara H, Taya C, Karaplis AC, Kominami R, and Wakabayashi Y
The parathyroid hormone regulates skin tumour susceptibility in mice.
Scientific Reports 7(1):11208, 2017. DOI:10.1038/s41598-017-11561-x - Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I, Wakana S, Yamaguchi M, Shitara H, Taya C, Karaplis AC, Kominami R, and Wakabayashi Y.
The parathyroid hormone regulates skin tumour susceptibility in mice.
Scientific Reports 7 (1):11208, 2017. - Murakami Y, Fukui R, Motoi Y, Shibata T, Saitoh SI, Sato R, Miyake K.
The Protective Effect of the anti-Toll-like Receptor 9 Antibody Against Acute Cytokine Storm Caused by Immunostimulatory DNA.
Sci Rep 7:44042, 2017. DOI:10.1038/srep44042 - Kake S, Tsuji S, Enjoji S, Hanasaki S, Hayase H, Yabe R, Tanaka Y, Nakagawa T, Liu HP, Chang SC, Usui T, Ohama T*, Sato K
The Role of SET/I2PP2A in canine mammary tumors.
Scientific Reports 27:4279, 2017. DOI:10.1038/s41598-017-04291-7 - Takakura Y, Yamaguchi N, Honda T, Morii M, Yuki R, Nakayama Y, Yamaguchi N
The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALK(ATI)) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner.
Biol Pharm Bull. 40(11):1968-1975, 2017. DOI:10.1248/bpb.b17-00548 - Yuichiro Yoneoka, Junichi Yoshimura, Masakazu Sano, Masayasu Okada, Akiyoshi Kakita, Yukihiko Fujii
Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement.
Pediatr Neurosurg. 53(1):49-54, 2017. DOI:10.1159/000480021 - Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI.
Thymidine Catabolism as a Metabolic Strategy for Cancer Survival.
Cell Reports 19:1313-1321, 2017. DOI:10.1016/j.celrep.2017.04.061 - Ogura H, Nagatake-Kobayashi Y. Adachi J, Tomonaga T, Fujita N, *Katayama R.
TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity.
Scientific Reports 7:5519, 2017. DOI:10.1038/s41598-017-05736-9 - Saitoh S, Abe F, Kanno A, Tanimura N, Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K, and Miyake K
TLR7 Mediated Viral Recognition Results in Focal Type I Interferon Secretion by Dendritic Cells.
Nat. Commun. 8(1):1592, 2017. DOI:10.1038/s41467-017-01687-x - Eisuke Sato, Miho Sato, Yurika Tanabe, Naoya Nakajima, Akifumi Ohkubo, Kiyotake Suenaga
Total Synthesis of Biselyngbyaside.
The Jornal of Organic Cehmistry 82 (13):6770-6777, 2017. DOI:10.1021/acs.joc.7b00905 - Wong-Lin K, Wang DH, Moustafa AA, Cohen JY, Nakamura K.
Toward a multiscale modeling framework for understanding serotonergic function.
Journal of psychopharmacology 31(9):1121-1136, 2017. DOI:10.1177/0269881117699612 - Magi S, Iwamoto K, Yumoto N, Hiroshima M, Nagashima T, Ohki R, Garcia-Munoz A, Volinsky N, Kriegsheim AV, Sako Y, Takahashi K, Kimura S, Kholodenko BN, Okada-Hatakeyama M
Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization.
J Biol Chem 293:2206-2218., 2017. DOI:10.1074/jbc.M117.778399 - Nomiyama H, Osada N, Takahashi I, Terao K, Yamagata K, Yoshie O
Translational repression of a splice variant of cynomolgus macaque CKCL1L by its C-terminal sequence.
Journal of Interferon and Cytokine Research 37:129-138, 2017. DOI:10.1089/jir.2016.0085 - Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K*.
Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Exp Neurol 293:1-12, 2017. DOI:10.1016/j.expneurol.2017.03.009 - Kano M, Watanabe T
Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease.
F1000Research 6:416, 2017. DOI:10.12688/f1000research.10485.1 - Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R.
Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.
Cell Res. 27:657-6674, 2017. DOI:10.1038/cr.2017.40 - Oh Y-M, Karube F…Fujiyama F. et al.
Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations.
Brain Struct Funct 222:2359-2378, 2017. DOI:10.1007/s00429-016-1346-2 - Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T.
Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.
JCI Insight 2(1):e89462, 2017. DOI:10.1172/jci.insight.89462 - Honda T, Morii M, Nakayama Y, Suzuki K, Yamaguchi N, Yamaguchi N
v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling.
Sci Rep. 8:1063, 2017. DOI:10.1038/s41598-018-19599-1 - Aonuma H., Kaneda M., Hatakeyama D., Watanabe T., Lukowiak K. and Ito E.
Weak involvement of octopamine in aversive taste learning in a snail.
Neurobiol. Learn. Mem. 141:189-198, 2017. DOI:10.1016/j.nlm.2017.04.010 - 斎藤慎一， 片村友大， 武藤雄一郎
アジリジン，アゼチジンの環拡大反応を利用したN-ヘテロ環合成法の開発.
有機合成化学協会誌 75:340-348, 2017. DOI:10.5059/yukigoseikyokaishi.75.340 - 山中章弘
オレキシン神経活動操作による機能解明.
睡眠医療 11(1):19-25, 2017. - 設樂久志，小川宏人
コオロギの音源定位ナビゲーション－神経行動学が迫る動物のナビゲーションメカニズム.
生物の科学 遺伝 71:519-525, 2017. - Iijima J, Kobayashi S, Kitazume S, Kizuka Y, Fujinawa R, Korekane H, Shibata T, Saitoh SI, Akashi-Takamura S, Miyake K, Miyoshi E, Taniguchi N.
タンパク質におけるフコース修飾の意義の解析.
Glycobiology 27(11):1006-1015, 2017. DOI:10.1093/glycob/cwx075 - Sato R*, Shibata T*, Tanaka Y, Kato C, Yamaguchi K, Furukawa Y, Shimizu E, Yamaguchi R, Imoto S, Miyano S, Miyake K. (* equally contributed)
ノックアウトライブラリーを用いた分子探索.
Int Immunol 29(8):347-355, 2017. DOI:10.1093/intimm/dxx044 - 河原康一、古川龍彦
核小体によるp53制御とがん治療薬開発の新展開.
実験医学 35:2365-2367, 2017. - 山中章弘
光遺伝学による神経科学研究の新展開.
医学のあゆみ 262(5):491-495, 2017. - 山中章弘
光遺伝学による睡眠覚醒の制御.
生体の科学 65(5):484-485, 2017. - Otsuka I, Izumi T, Boku S, Kimura A, Zhang Y, Mouri K, Okazaki S, Shiroiwa K, Takahashi M, Ueno Y, Shirakawa O, Sora I, Hishimoto A.
自殺既遂者におけるテロメア長とミトコンドリアDNAコピー数の研究.
Sci Rep. 7(1):31-76, 2017. - 山中章弘
睡眠のマニピュレーション-光遺伝学、薬理遺伝学を用いた睡眠覚醒の操作.
医学のあゆみ 263(9):765-774, 2017. - Wu MK, Takemoto M, Taniguchi M, Takumi T, Okazaki T, Song W-J.
Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1.
American Journal of Physiology-Cell Physiology 311(1):C15-23, 2016. DOI:10.1152/ajpcell.00272.2015 - 岡田正康
軸索再生に対するGAP-43の機能解明:GAP-43 (Ser96)のリン酸化は軸索再生の分子マーカーとなる.
新潟医学会雑誌 130(7):405-419, 2016. - Katsutoshi Imamura, Akiko Takaya, Yo-ichi Ishida, Yayoi Fukuoka, Toshiki Taya, Ryo Nakaki, Miho Kakeda, Naoto Imamachi, Aiko Sato, Toshimichi Yamada, Yutaka Suzuki, Masami Nagahama, Tomoko Yamamot, Torben Heick Jensen, Nobuyoshi Akimitsu
Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs.
EMBO Journal
2016年度
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A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors.
Journal of Experimental & Clinical Cancer Research 38:127, 2019. DOI:10.1186/s13046-019-1121-3 - Kanetake T, Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, Kihara A
Neural symptoms in a gene knockout mouse model of Sj?gren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide.
FASEB Journal 33:928-941, 2019. DOI:10.1096/fj.201800291R - Kasahara Y, Sakakibara Y, Hiratsuka T, Moriya Y, Lesch KP, Hall FS, Uhl GR, Sora I
Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice.
Neuropsychopharmacology Reports 39:130-133, 2019. DOI:10.1002/npr2.12049 - Kano T., Sato E., Ono T., Aonuma H., Matsuzaka Y. and Ishiguro A.
A brittle star-like robot capable of immediately adapting to unexpected physical damage.
Royal Soc. Open Sci. 4:171200, 2018. DOI:10.1098/rsos.171200 - Sumitani M, Nishizawa D, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain.
Pain Medicine 19:348-354, 2018. DOI:10.1093/pm/pnx102 - DiRienzo, N. and Aonuma H.
Plasticity in extended phenotype increases offspring defense despite individual variation in web structure and behavior.
Animal Behav. 138:9ｰ17, 2018. DOI:10.1016/j.anbehav.2018.01.022 - Kai Kitamura, Hiroaki Itoh, Kaori Sakurai, Shingo Dan, Masayuki Inoue
Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase.
Journal of the American Chemical Society 140(38):12189-12199, 2018. DOI:10.1021/jacs.8b07339 - Motohiro Nozumi, Michihiro Igarashi
Vesicular movements in the growth cone.
Neurochemistry International 119:71-76, 2018. DOI:10.1016/j.neuint.2017.09.011 - Shiratori C., Suzuki N., Momohara Y., Shiraishi K., Aonuma H., and Nagayama T.
Cyclic AMP-regulated opposing and parallel effects of serotonin and dopamine on phototaxis in the Marmorkrebs (marbled crayfish).
Europ. J. Neurosci. 46:1863-1874, 2017. DOI:10.1111/ejn.13632 - Saito T, Ishii A, Sugai K, Sasaki M, Hirose S.
A de novo missense mutation in SLC12A5 found in a compound heterozygote patient with epilepsy of infancy with migrating focal seizures.
Clinical Genetics 92(6):654-658, 2017. DOI:10.1111/cge.13049 - Matsumoto M., Matsuzaki F., Oshikawa K., Goshima N., Mori M., Kawamura Y., Ogawa K., Fukuda E., Nakatsumi H., Natsume T., Fukui K., Horimoto K., Nagashima T., Funayama R., Nakayama K. & Nakayama KI.
A large-scale targeted proteomics assay resource based on an in vitro human proteome.
Nature Methods 14:251-8, 2017. DOI:10.1038/nmeth.4116 - Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, *Komatsu M.
A novel approach to assess the ubiquitin-fold modifier 1-system in cells.
FEBS Lett. 591:196-204, 2017. DOI:10.1002/1873-3468.12518 - Uchida T, Lossin C, Ihara Y, Deshimaru M, Yanagawa Y, Koyama S, Hirose S.
Abnormal gamma-aminobutyric acid neurotransmission in a Kcnq2 model of early onset epilepsy.
Epilepsia 58(8):1430-1439, 2017. DOI:10.1111/epi.13807 - Ayumi Hashimoto, Toyohiro Sawada, Itsuki Kageyama, Kiyohisa Natsume
Activation of the muscarinic receptors induces the transition of the epileptic discharges to beta oscillation in hippocampal slices.
Biophysics_and Physicobiology 14:137-146, 2017. DOI:10.2142/biophysico.14.0_137 - *Ueno T, *Komatsu M.
Autophagy in the liver: functions in health and disease.
Nat Rev Gastroenterol Hepatol. 14:170-184, 2017. DOI:10.1038/nrgastro.2016.185 - Uchibori K, Inase N, Araki M, Kamada M, Sato S, Okuno Y, Fujita N, *Katayama R.
Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer.
Nature communications 8:14768, 2017. DOI:10.1038/ncomms14768 - Sho Wakayama, Shigeki Kiyonaka, Itaru Arai, Wataru Kakegawa, Shinji Matsuda, Keiji Ibata, Yuri L. Nemoto, Akihiro Kusumi, Michisuke Yuzaki & Itaru Hamachi
Chemical labeling for visualizing native AMPA receptors in live neurons.
Nature Communications 8:e14850, 2017. DOI:10.1038/ncomms14850 - Ishii A, Watkins JC, Chen D, Hirose S, Hammer MF.
Clinical implications of SCN1A missense and truncation variants in a large Japanese cohort with Dravet syndrome.
Epilepsia 58(2):282-290, 2017. DOI:10.1111/epi.13639 - Jun Nakayama, Emi Ito, Jiro Fujimoto, Shinya Watanabe and Kentaro Semba
Comparative analysis of gene regulatory networks of highly metastatic breast cancer cells established by orthotopic transplantation and intra-circulation injection.
International Journal of Oncology 50.2:497-504, 2017. DOI:10.3892/ijo.2016.3809 - Nozumi M, Nakatsu F, Katoh K, *Igarashi M
Coordinated movement of vesicles and actin bundles during nerve growth revealed by superresolution microscopy.
Cell Rep 18:2203-2216, 2017. DOI:10.1016/j.celrep.2017.02.008 - Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.
J Clin Endocrinol Metab 101(3):841-6, 2017. DOI:10.1210/jc.2015-2855 - Goto E, Tokunaga F.
Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.
Biochemical and Biophysical Research Communications 485(1):152-159, 2017. DOI:10.1016/j.bbrc.2017.02.040 - Gen Shiihashi, Daisuke Ito, Itaru Arai, Yuki Kobayashi, Kanehiro Hayashi, Shintaro Otsuka, Kazunori Nakajima, Michisuke Yuzaki, Shigeyoshi Itohara, Norihiro Suzuki
Dendritic homeostasis disruption in a novel frontotemporal dementia mouse model expressing cytoplasmic fused in sarcoma.
EBioMedicine 24:102-115, 2017. DOI:10.1016/j.ebiom.2017.09.005 - Kanki, Y., Nakaki, R., Shimamura, T., Matsunaga, T., Yamamizu, K., Katayama, S., Suehiro, J.I., Osawa, T., Aburatani, H., Kodama, , and Minami, T
Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation.
Nuc.Acids.Res 2017 45:4344-58, 2017. - Furuya M, Hasumi H, Baba M, Tanaka R, Iribe Y, Onishi T, Nagashima Y, Nakatani Y, Isono Y, Yao M
Establishment and characterization of BHD-F59RSVT, an immortalized cell line derived from a renal cell carcinoma in a patient with Birt-Hogg-Dub? syndrome.
Laboratory Investigation 97(3):343-351, 2017. DOI:10.1038/labinvest.2016.137 - Honda A, Ito Y, Takahashi-Niki K, Matsushita N, Nozumi M, Tabata H, Takeuchi K, *Igarashi M
Extracellular signals induce glycoprotein M6a clustering of lipid rafts and associated signaling molecules.
J Neurosci 37:4046-4064, 2017. DOI:10.1523/JNEUROSCI.3319-16.2017 - Yamauchi T., Nishiyama M., Moroishi T., Kawamura A., Nakayama KI.
FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem-progenitor cells.
Mol. Cell. Biol. 37:e00470-16, 2017. DOI:10.1128/MCB.00470-16 - Tanabe K, Shinsato Y, Furukawa T, Kita Y, Hatanaka K, Minami K, Kawahara K, Yamamoto M, Baba K, Mori S, Uchikado Y, Maemura K, Tanimoto A, Natsugoe S
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
Oncotarget 8:6353-6363, 2017. DOI:10.18632/oncotarget.14087 - Kayama K., Watanabe S., Takafuji T., Tsuji T., Hironaka K., Matsumoto M., Nakayama KI., Enari M., Kohno T., Shiraishi K., Kiyono T., Yoshida K., Sugimoto N., Fujita M.
GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
EMBO Rep. 18:123-37, 2017. DOI:10.15252/embr.201642444 - Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue J.
HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.
PLoS Pathogens 13:e100162, 2017. DOI:10.1371/journal.ppat.1006162 - Jinshu Xu, Ueno H,Chelsea Xu, Binglai Chen, Irving Weissman, and Pin-Xian Xu.
Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti.
Nature Communications 8, 15046, 2017. DOI:10.1038/ncomms15046 - Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y.
Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice.
Gastroenterology 152(1):218-231.e14, 2017. DOI:10.1053/j.gastro.2016.09.018 - T. Hara, T. Kojima, H. Matsuzaki, T. Nakamura, E. Yoshida, Y. Fujiwara, C. Yamamoto, S. Saito, T. Kaji
Induction of Syndecan-4 by Organic-Inorganic Hybrid Molecules with a 1,10-Phenanthroline Structure in Cultured Vascular Endothelial Cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18:352, 2017. DOI:10.3390/ijms18020352 - Numata T, Tsumoto K, Yamada K, Kurokawa T, Hirose S, Nomura H, Kawano M, Kurachi Y, Inoue R, Mori Y.
Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing.
Scientific Reports 7(1):9760, 2017. DOI:10.1038/s41598-017-10357-3 - Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Saiga K, Ohsugi H, Tokuyama Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M, and Ueno H.
Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion.
Scientific Reports 7, 41838, 2017. DOI:10.1038/srep41838 - Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Saiga K, Ohsugi H, Tokuyama Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M, and Ueno H.
Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity.
Scientific Reports 7, 9891, 2017. DOI:10.1038/s41598-017-09927-2 - Jin M, Pomp O, Shinoda T, Toba S, Torisawa T, Furuta K, Oiwa K, Yasunaga T, Kitagawa D, Matsumura S, Miyata T, Tan TT, Reversade B, Hirotsune S.
Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.
Sci Rep. 7:e39902, 2017. DOI:10.1038/srep39902 - Zamani A, Sakuragi S, Ishizuka T, Yawo H.
Kinetic characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization.
Biophys Physicobiol. 14:13-22, 2017. DOI:10.2142/biophysico.14.0_13 - Jin Cui, Maho Morita, Osamu Ohno, Tomoyuki Kimura, Toshiaki Teruya, Takumi Watanabe, Kiyotake Suenaga, and Masakatsu Shibasaki:
Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis.
Chemistry An Eurean Journal 23 (35):8500-8509, 2017. DOI:10.1002/chem.201701183 - Nakamura, Y., Yanagawa, Y., Morrison, S.F., Nakamura, K.
Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication.
Cell Metabolism 25:322?334, 2017. DOI:10.1016/j.cmet.2016.12.002 - Matsumoto A., Pasut A., Matsumoto M., Yamashita R., Fung J., Saghatelian A., Nakayama KI., Clohessy JG., Monteleone E., Pandolfi PP.
mTORC1 and muscle regeneration are regulated by the LINC00961 encoded SPAR polypeptide.
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Muscular mechanical hyperalgesia after lengthening contractions in rats depends on stretch velocity and range of motion.
European Journal of Pain 21(1):125-139, 2017. DOI:10.1002/ejp.909 - Misako Matsushita, Yuhki Nakatake, Itaru Arai, Keiji Ibata, Kazuhisa Kohda, Sravan Goparaju, Miyako Murakami, Miki Sakota, Nana Chikazawa-Nohtomi, Shigeru Ko, Takanori Kanai, Michisuke Yuzaki & Minoru S.H. Ko
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Biochemical and Biophysical Research Communications 490:296-301, 2017. DOI:10.1016/j.bbrc.2017.06.039 - Ishii A, Hirose S.
New Genes for Epilepsy - Autism Comorbidity.
Journal of Pediatric Neurology 15(3):105-114, 2017. DOI:10.1055/s-0037-1602822 - Matsuzaka Y, Sato E., Kano T., Aonuma H. and Ishiguro A.
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Biology Open 6:425-438, 2017. DOI:10.1242/bio.019836 - Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Ueno H, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, and Kuo CJ.
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Nature 545:238-242, 2017. DOI:10.1038/nature22313 - Sasaki M, Ishii A, Saito Y, Hirose S.
Progressive Brain Atrophy in Alternating Hemiplegia of Childhood.
Movement Disorders Clinical Practice 4(3):406-411, 2017. DOI:10.1002/mdc3.12451 - Furuse T., Miyake K., Kohda T., Kaneda H., Hirasawa T., Yamada I., Kushida T., Kashimura M., Kobayashi K., Ishino F., Kubota T., Wakana S.
Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny.
Genes & Nutrition , 2017. DOI:10.1186/s12263-016-0550-2 - Hammer MF, Ishii A, Johnstone L, Tchourbanov A, Lau B, Sprissler R, Hallmark B, Zhang M, Zhou J, Watkins J, Hirose S.
Rare variants of small effect size in neuronal excitability genes influence clinical outcome in Japanese cases of SCN1A truncation-positive Dravet syndrome.
PLoS ONE 12(7):e0180485, 2017. DOI:10.1371/journal.pone.0180485 - Morinaga T, Yanase S, Okamoto A, Yamaguchi N, Yamaguchi N
Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells.
Sci Rep. 7:493, 2017. DOI:10.1038/s41598-017-00538-5 - Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H.
Reduced SHARPIN and LUBAC formation may contribute to CCl4- or acetaminophen-induced liver cirrhosis in mice.
International Journal of Molecular Sciences 18:326, 2017. DOI:10.3390/ijms18020326 - Morii M, Kubota S, Honda T, Yuki R, Morinaga T, Kuga T, Tomonaga T, Yamaguchi N, Yamaguchi N
Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530.
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Sci. Rep. 7:41130, 2017. DOI:10.1038/srep41130 - T. Fukuda, T. Katae, I. Harada, M. Iwao
Synthesis of Lamellarins via Regioselective Assembly of 1,2-Diarylated [1]Benzopyrano[3,4-b]pyrrol-4(3H)-one Core.
Heterocycles 95 (2):950-971, 2017. DOI:10.3987/COM-16-S(S)63 - Katamura, T.; Shimizu, T.; Mutoh, Y.; Saito, S.
Synthesis of Tricyclic Benzazocines by Aza-Prins Reaction.
Organic Letters 19(1):266-269, 2017. DOI:10.1021/acs.orglett.6b03577 - Hanaya R, Niantiarno FH, Kashida Y, Hosoyama H, Maruyama S, Otsubo T, Tanaka K, Ishii A, Hirose S, Arita K.
Vagus nerve stimulation for genetic epilepsy with febrile seizures plus (GEFS+) accompanying seizures with impaired consciousness.
Epilepsy & Behavior Case Reports 7:16-19, 2017. DOI:10.1016/j.ebcr.2016.11.001 - 山中章弘
睡眠覚醒調節におけるオレキシンの役割.
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動物心理学研究における還元・比較・発生―研究遍歴をめぐる対談をふまえて―.
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CHD7 promotes proliferation of neural stem cells mediated by MIF.
Molecular Brain 9(1):96, 2016. DOI:10.1186/s13041-016-0275-6 - Etsu Tashiro, Shizuka, Henmi, Hiroyuki Odake, Seitaro Ino, Masaya Imoto
Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation.
Biochem Biophys Res Commun 477:801-806, 2016. DOI:10.1016/j.bbrc.2016.06.138 - Muramatsu, M. and Minami, T
Oncogenic combined calcineurin-NFAT and TLR signals in colon.
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Novel Method to Rescue a Lethal Phenotype Through Integration of Target Gene Onto the X-chromosome.
Sci Rep. 6:37200, 2016. DOI:10.1038/srep37200 - Hoque MR, Ishizuka T, Inoue K, Abe-Yoshizumi R, Igarashi H, Mishima T, Kandori H, Yawo H.
A Chimera Na+-Pump Rhodopsin as an Effective Optogenetic Silencer.
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A de novo missense mutation of GABRB2 causes early myoclonic encephalopathy.
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A Novel Reporter Rat Strain That Conditionally Expresses the Bright Red Fluorescent Protein tdTomato.
PLoS One. 11(5):e0155687, 2016. DOI:10.1371/journal.pone.0155687 - Ayumi Suzuki, Takahiro Arai, Kota Ikenaga, Yuichiro Mutoh, Noriko Tsuchida, Scinchi Saito, Youichi Ishii
A ruthenium tellurocarbonyl (CTe) complex with a cyclopentadienyl ligand: Systematic studies of a series of the chalcogenocarbonyl complexes [CpRuCl(CE)(H2IMes)] (E = O, S, Se, Te).
DALTON TRANSACTIONS 46:44 - 48, 2016. DOI:10.1039/C6DT04440A - Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T, Yamaoka S.
A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.
Leukemia 30(3):716-727, 2016. DOI:10.1038/leu.2015.267 - Ohta H, Kohno Y, Arake M, Tamura R, Yukawa S, Sato Y, Morimoto Y, Nishida Y, Yawo H.
Adrenergic receptor-mediated modulation of striatal firing patterns.
Neurosci Res. 112:47-56, 2016. DOI:10.1016/j.neures.2016.05.004 - Hosokawa H., Tanaka T., Endo Y., Kato M., Shinoda K., Suzuki A., Motohashi S., Matsumoto M., Nakayama KI., Nakayama T.
Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.
Nature Commun. 7:11289, 2016. DOI:10.1038/ncomms11289 - Connor SA, Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Kurihara N, Tada A, Ge Y, Lu H, Yan R, LeDue JM, Matsumoto M, Kiyonari H, Kirino Y, Matsuzaki F, Suzuki T, Murphy TH, Wang YT, Yamamoto T, Craig AM
Altered cortical dynamics and cognitive function upon haploinsufficiency of the autism linked excitatory synaptic suppressor MDGA2.
Neuron 91:1052-1068, 2016. DOI:10.1016/j.neuron.2016.08.016 - Yamashita-Sugahara Y, Matsumoto M, Ohtaka M, Nishimura K, Nakanishi M, Mitani K, Okazaki Y
An inhibitor of Fibroblast Growth Factor Receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors.
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Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.
Biochim Biophys Acta. 1861:1816-1827, 2016. DOI:10.1016/j.bbalip.2016.09.006 - Saito S, Fujimaki T, Panbangred W, Igarashi Y and Imoto M
Antarlides, A new-type of Androgen Receptor (AR) Antagonist, that overcomes resistance to AR-targeted Therapy.
Angewandte Chemie Int. Ed. 55:2728-2732, 2016. DOI:10.1002/anie.201510079 - Moinuddin FM, Shinsato Y, Komatsu M, Mitsuo R, Minami K, Yamamoto M, Kawahara K, Hirano H, Arita K, Furukawa T
ATP7B expression confers multidrug resistance through drug sequestration.
Oncotarget 7:22779-90, 2016. DOI:10.18632/oncotarget.8059 - Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A.
Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.
Elife 5, 2016. DOI:10.7554/eLife.14810 - Muona, M., *Lehesjoki, AE., *Komatsu, M (28人中28番目).
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.
Am. J. Hum. Genet 99:683-694, 2016. DOI:10.1016/j.ajhg.2016.06.020 - Tanaka T, Atsumi N, Nakamura N, Yanai H, Komai Y, Omachi T, Tanaka K, Saiga K, Ohsugi H, Tokuyama Y, Hisha H, Yoshida N, Kumano K, Okazaki K, and Ueno H.
Bmi1-positive cells in the lingual epithelium could serve as cancer stem cells in tongue cancer.
Scientific Reports 6, 39386, 2016. DOI:10.1038/srep39386 - Tuboly E, Futakuchi M, Varga G, Erces D, Tokes T, Meszaros A, Kaszaki J, Suzui M, Imai M, Okada A, Okada N, Boros M, Okada H
C5a inhibitor protects ischemia/reperfusion injury in rat small intestine.
Microbiol Immunol 60(1):35-46, 2016. DOI:10.1111/1348-0421 - Mehanna S, Suzuki C, Shibata M, Sunabori T, Imanaka T, Araki K, Yamamura K, Uchiyama Y,?Ohmuraya?M
Cathepsin D in Pancreatic Acinar Cells Is Implicated in Cathepsin B and L Degradation, but Not in Autophagic Activity.
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Cellular tagging as a neural network mechanism for behavioral tagging.
Nature Communications 7:12319, 2016. DOI:10.1038/ncomms12319 - Hiroshi Yamada , Hitoshi Inokawa , Yukiko Hori , Xiaochuan Pan , Ryuichi Matsuzaki , Kae Nakamura , Kazuyuki Samejima , Munetaka Shidara d, Minoru Kimura , Masamichi Sakagami , Takafumi Minamimoto
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Neuroscience research 105:2-18, 2016. DOI:10.1016/j.neures.2015.10.003 - Motojima M, Tanimoto S, Ohtsuka M, Matsusaka T, Kume T, Abe K
Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2.
Cells Tissues Organs 201:380-389, 2016. DOI:10.1159/000445027 - Katayama Y., Nishiyama M., Shoji H., Ohkawa Y., Kawamura A., Sato T., Suyama M., Takumi T., Miyakawa T., Nakayama KI.
CHD8 haploinsufficiency results in autistic-like phenotypes in mice.
Nature 537:675-9, 2016. DOI:10.1038/nature19357 - Yan M, Audet-Walsh ?, Manteghi S, Rosa Dufour C, Walker B, Baba M, St-Pierre J, Gigu?re V, Pause A
Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.
Genes & Development 30(9):1034-1046, 2016. DOI:10.1101/gad.281410.116 - Kimura, H., Fumoto, K., Shojima, K., Nojima, S., Osugi, Y., Tomihara, H., Eguchi, H., Shintani, Y., Endo, E., Inoue, M., Doki, Y., Okumura, M., Morii, E., and Kikuchi, A
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression.
J Clin. Invest. 126(7):2689-2705, 2016. DOI:10.1172/JCI84658 - Motojima M, Ogiwara S, Matsusaka T, Kim SY, Sagawa N, Abe K, Ohtsuka M.
Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system.
Mammalian genoem 27:62-69, 2016. DOI:10.1007/s00335-015-9610-y - Koso H, Tsuhako A, Lai CY, Baba Y, Otsu M, Ueno K, Nagasaki M, Suzuki Y, Watanabe
Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina.
Glia 64(11):2005-2024, 2016. DOI:10.1002/glia.23038 - Matsumoto N, Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, Siomi MC, Nureki O.
Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA.
Cell 167:484-497, 2016. DOI:10.1016/j.cell.2016.09.002 - Jayapal SR, Ang HY, Wang CQ, Bisteau X, Caldez MJ, Xuan GX, Yu W, Tergaonkar V, Osato M, Lim B, Kaldis P.
Cyclin A2 regulates erythrocyte morphology and numbers.
Cell Cycle 15(22):3070-3081, 2016. DOI:10.1080/15384101.2016.1234546 - T. Hara, H. Matsuzaki, T. Nakamura, E. Yoshida, T. Ohkubo, H. Maruyama, C. Yamamoto, S. Saito, T. Kaji
Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells.
Fundamental Toxicological Sciences 3:109 - 113, 2016. DOI:10.2131/fts.3.109 - Saito A, Taniguchi Y, Kim SH, Selvakumar B, Perez G, Ballinger MD, Zhu X, Sabra J, Jallow M, Yan P, Ito K, Rajendran S, Hirotsune S, Wynshaw-Boris A, Snyder SH, Sawa A, Kamiya A.
Developmental Alcohol Exposure Impairs Activity-Dependent S-Nitrosylation of NDEL1 for Neuronal Maturation.
Cereb Cortex. 27:3918-3929., 2016. DOI:10.1093/cercor/bhw201 - *Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D
Direct Projections from Hypothalamic Orexin Neurons to Brainstem Cardiac Vagal Neurons.
Neuroscience 339:47-53, 2016. DOI:10.1016/j.neuroscience.2016.09.038 - Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, Kihara A
Disruption of the Sj?gren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
Journal of Biological Chemistry 291(22):11676-11688, 2016. DOI:10.1074/jbc.M116.714030 - Hengguang Zhao, Rieger S, Abe K, Hewison M, Lisse T.
DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization.
Int. J. Mol. Sci. 17:1984, 2016. DOI:10.3390/ijms17121984 - Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T.
Dopamine D2L receptor is required for visual discrimination learning.
Molecular Neuropsychiatry 2 (3):124-132, 2016. DOI:10.1159/000447970 - 山中章弘
DREADD による神経活動操作と精神医学研究.
分子精神医学 16(3):45(189)-47(191), 2016. - Tsuji, M., Takahashi, Y., Watabe, A.M., Kato, F.
Enhanced long-term potentiation in mature rats with a history of cryptogenic infantile spasms.
Epilepsia 57(3):495-505, 2016. DOI:10.1111/epi.13315 - Fujii, S., Shinjo, K., Matsumoto, S., Harada, T., Nojima, S., Sato, S., Usami, Y., Toyosawa, S., Morii, E., Kondo, Y., and Kikuchi, A
Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3'-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma.
Oncotarget 7:81571-81587, 2016. DOI:10.18632/oncotarget.13147 - Kikuta S, Ynagawa Y, Homma N, Osanai M
Evaluation of the amount of the manganese entry in the neurons for activity-induced manganese-enhanced MRI.
Electronics and Communications in Japan 99(8):48-53, 2016. DOI:10.1002/ecj.11838 - Adachi T, Hayashi T
Evolutionarily conserved phosphorylation and palmitoylation-dependent regulation of dopamine D1-like receptors in vertebrates.
Neurotransmitter 3:e1434, 2016. DOI:10.14800/nt.1434 - Pei W Tanaka K, Huang SC, Xu L, Liu B, Sinclair J, Idol J, Varshney GK, Huang H, Lin S, Nussenblatt RB, Mori R, Burgess SM
Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation.
NPJ Regen Med 1:16013, 2016. DOI:10.1038/npjregenmed.2016.13 - Lee DH, Han DH, Nam KT, Park JS, Kim SH, Lee M, Kim G, Min BS, Cha BS, Lee YS, Sung SH, Jeong H, Ji HW, Lee MJ, Lee JS, Lee HY, Chun Y, Kim J, Komatsu M, Lee YH, Bae SH.
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
Free Radic Biol Med. 99:520-532, 2016. DOI:10.1016/j.freeradbiomed.2016.09.009 - Horigane S*, Ageta-Ishihara N*(*共同筆頭著者), Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S, Bito H.
Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKI? pathway during neuronal polarization.
Molecular brain 9(1):8, 2016. DOI:10.1186/s13041-016-0189-3 - Nomir AG., Takeuchi Y. et al.
Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1-Cre mice.
Genesis 54(7):379-388, 2016. DOI:10.1002/dvg.22951 - Nita A., Nishiyama M., Muto Y., Nakayama KI.
FBXL12 regulates T cell differentiation in a cell-autonomous manner.
Genes Cells 5:517-24, 2016. DOI:10.1111/gtc.12360 - Kitade S., Onoyama I., Kobayashi H., Yagi H., Yoshida S., Kato M., Tsunematsu R., Asanoma K., Sonoda K., Wake N., Hata K., Nakayama KI., Kato K.
FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors.
Cancer Sci. 107:1399-405, 2016. DOI:10.1111/cas.13026 - Hadano S, Mitsui S, Pan L, Otomo A, Kubo M, Sato K, Ono S, Onodera W, Abe K, Chen X, Koike M, Uchiyama Y, Aoki M, Warabi E, Yamamoto M, Ishii T, Yanagawa T, Shang H-F, Yoshii F.
Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.
Human Molecular Genetics 25:25, 2016. DOI:10.1093/hmg/ddw180 - Okamoto M, Nakayama Y, Kakihana A, Yuki R, Yamaguchi N, Yamaguchi N
Fyn Accelerates M Phase Progression by Promoting the Assembly of Mitotic Spindle Microtubules.
J Cell Biochem. 117(4):610-623, 2016. DOI:10.1002/jcb.25373 - Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M.
Generation of a new model rat: Nrf2 knockout rats are sensitive to aflatoxin B1 toxicity.
Toxicol Sci 152:40-52, 2016. DOI:10.1093/toxsci/kfw065 - Ishikawa T, Imamura K, Kondo T, Koshiba Y, Hara S, Ichinose H, Furujo M, Kinoshita M, Oeda T, Takahashi J, Takahashi R, Inoue H
Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders.
Hum Mol Genet 25:5188-5197, 2016. DOI:10.1093/hmg/ddw339 - Furuya M, Yao M, Tanaka R, Nagashima Y, Kuroda N, Hasumi H, Baba M, Matsushima J, Nomura F, Nakatani Y
Genetic, epidemiologic and clinicopathologic studies of Japanese Asian patients with Birt-Hogg-Dub? syndrome.
Clinical Genetics 90(5):403-412, 2016. DOI:10.1111/cge.12807 - Taki K, Ohmuraya M, Tanji E, Komatsu H, Hashimoto D, Semba K, Araki K, Kawaguchi Y, Baba H, Furukawa T.
GNAS(R201H) and Kras(G12D) Cooperate to Promote Murine Pancreatic Tumorigenesis Recapitulating Human Intraductal Papillary Mucinous Neoplasm.
Oncogene 35（18）:2407-2412, 2016. DOI:10.1038/onc.2015.294 - Futakuchi M, Fukamachi K, Suzui M
Heterogeneity of tumor cells in the bone microenvironment: mechanisms and therapeutic targets for bone metastasis of prostate or breast cancer.
Adv Drug Deliv Rev 99, 2016. DOI:10.1016/j.addr.2015.11.017 - Yoshikawa Y, Emi M, Hashimoto-Tamaoki T, Ohmuraya M, Sato A, Tsujimura T, Hasegawa S, Nakano T, Nasu M, Pastorino S, Szymiczek A, Bononi A, Tanji M, Pagano I, Gaudino G, Napolitano A, Goparaju C, Pass HI, Yang H, Carbone M.
High-density array-CGH With Targeted NGS Unmask Multiple Noncontiguous Minute Deletions on Chromosome 3p21 in Mesothelioma.
Proc Natl Acad Sci U S A. 113(47):13432-13437, 2016. DOI:10.1073/pnas.1612074113 - Wani S., Sugita A., Ohkuma Y., and Hirose Y.
Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation.
The Journal of Biochemistry 160(2):111-120, 2016. DOI:10.1093/jb/mvw018 - *Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D
Hypoxia and hypercapnia inhibit hypothalamic orexin neurons in rats.
Journal of Neurophysiology 116(5):2250-2259, 2016. DOI:10.1152/jn.00196.2016 - Kubo H, Shimono R*,Nakamura S, Koyano K,Jinnai W, Yamato S, Yasuda S, Nakamura M, Tanaka A, Fujii T, Kanenishi K, Chiba Y, Miki T, Kusaka T, Ueno M.
Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets.
Neonatology 111(3)::203-10, 2016. DOI:10.1159/000450721 - Tanaka M., Shiota M., Nakao T., Uemura R., Nishi S., Ohkawa Y., Matsumoto M., Yamaguchi M., Osada-Oka M., Inagaki A., Takahashi K., Nakayama KI., Gi M., Izumi Y., Miura K., Iwao H.
Identification of low-abundance proteins in serum via the isolation of HSP72 complexes.
J. Proteomics 136:214-21, 2016. DOI:10.1016/j.jprot.2016.01.008 - Ueno H.
Identification of normal and neoplastic stem cells by the multicolor lineage tracing method.
Pathology International 66(8):423-430, 2016. DOI:10.1111/pin.12425 - Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T and Sumiko Watanabe S
Identification of RNA-binding protein LARP4B as a tumor suppressor in glioma.
Cancer Res. 76(8):2254-2264, 2016. DOI:10.1158/0008-5472.CAN-15-2308 - Yoshinori Asano, Tatsuya Kawase, Atsushi Okabe, Shuichi Tsutsumi, Hitoshi Ichikawa, Satoko Tatebe, Issay Kitabayashi, Fumio Tashiro, Hideo Namiki, Tadashi Kondo, Kentaro Semba, Hiroyuki Aburatani, Yoichi Taya, Hitoshi Nakagama and Rieko Ohki
IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.
Scientific Reports 6:19174, 2016. DOI:10.1038/srep19174 - Tetsuhisa Otani, Yosuke Ogura, Kazuyo Misaki, Takuya Maeda, Akiyo Kimpara, Shigenobu Yonemura, Shigeo Hayashi
IKKε inhibits PKC to promote Fascin-dependent actin bundling.
Development 143:3806-3816, 2016. DOI:10.1242/dev.138495 - Shibata N, Kashima M, Ishiko T, Nishimura O, Rouhana L, Misaki K, Yonemura S, Saito K, Siomi H, Siomi MC, Agata K.
Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian.
Dev. Cell 37:226-37., 2016. DOI:10.1016/j.devcel.2016.04.009 - Ye X, Zhou Q, Matsumoto Y, Moriyama M, Kageyama S, Komatsu M, Satoh S, Tsuchida M, Saijo Y.
Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma.
Anticancer Res. 36:6021-6029, 2016. - Lee W, Kim D, Rivnay J, Matsuhisa N, Lonjaret T, Yokota T, Yawo H, Sekino M, Malliaras GG, Someya T.
Integration of Organic Electrochemical and Field-Effect Transistors for Ultraflexible, High Temporal Resolution Electrophysiology Arrays.
Adv Mater. 28(44):9722-9728, 2016. DOI:10.1002/adma.201602237 - Wakaizumi K, Kondo T, Hamada Y, Narita M, Kawabe R, Narita H, Watanabe M, Kato S, Senba E, Kobayashi K, Kuzumaki N, Yamanaka A, Morisaki H, *Narita M
Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise: A study for specific neural control with Gi-DREADD in mice.
Molecular Pain 12:1744806916681567., 2016. DOI:10.1177/1744806916681567 - Iizuka K, Yokomizo T, Watanabe N, Tanaka Y, Osato M, Takaku T, Komatsu N.
Lack of Phenotypical and Morphological Evidences of Endothelial to Hematopoietic Transition in the Murine Embryonic Head during Hematopoietic Stem Cell Emergence.
PLoS One 11(5):e0156427, 2016. DOI:10.1371/journal.pone.0156427 - Maekawa T, Sasaoka T, Azuma S, Ichikawa T, Melrose HL, Farrer MJ, Obata F;
Leucine-rich repeat kinase 2 (LRRK2) regulates alpha-synuclein clearance in microglia.
BMC Neuroscience 17 (1):77, 2016. DOI:10.1186/s12868-016-0315-2 - Kanda M, Nagai T, Takahashi T, Liu ML, Kondou N, Naito AT, Akazawa H, Sashida G, Iwama A, Komuro I, Kobayashi Y.
Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction.
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Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nat Commun. 7:12547, 2016. DOI:10.1038/ncomms12547 - Baba M, Toyama H, Sun L, Takubo K, Suh H-C, Hasumi H, Nakamura-Ishizu A, Hasumi Y, Klarmann KD, Schmidt LS, Linehan WM, Suda T, Keller JR
Loss of Folliculin disrupts hematopoietic stem cell quiescence and homeostasis resulting in bone marrow failure.
Stem Cells 34(4):1068-1082, 2016. DOI:10.1002/stem.2293 - Sumiyoshi T, Sato K, Yamamoto H, Iwasaki YW, Siomi H, Siomi MC.
Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells.
Genes Dev. 30:1617-1622., 2016. DOI:10.1101/gad.283929.116 - Ichinose K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri S-Y, Iwamoto N, Tamai M, Arima K, Nakamura H, Obata Y, Yamamoto K, Origuchi T, Nishino T, Kawakami A and Tsokos GC
Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.
Arthritis and Rheumatology 68(4):944-952, 2016. DOI:10.1002/art.39499 - Saito M, Okumura K, Yoshizawa Y, Munakata H, Isogai E, and Wakabayashi Y.
Meis1 is required for c-Met inhibition to suppress cell proliferation of skin squamous cell carcinoma cells.
Journal of Biosciences and medicines 4(1):53-65, 2016. DOI:10.4236/jbm.2016.47007 - Fukaya R, Ohta S, Yaguchi T, Matsuzaki Y, Sugihara E, Okano H, Saya H, Kawakami Y, Kawase T, Yoshida K, Toda M.
MIF Maintains the Tumorigenic Capacity of Brain Tumor-Initiating Cells by Directly Inhibiting p53.
Cancer Res. 34:5667-5677, 2016. DOI:10.1158/0008-5472.CAN-15-1011 - Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, Mukaida N.
MIP-1α/CCL3-expressing Basophil-Lineage Cells Drive the Leukemic Hematopoiesis of Chronic Myeloid Leukemia in Mice.
Blood 127:2607-2617, 2016. DOI:10.1182/blood-2015-10-673087 - Suzui M, Futakuchi M, Fukamachi K, Numano T, Abd Elgied M, Takahashi S, Ohnishi M, Omori T, Tsuruoka S, Hirose A, Kanno J, Sakamoto Y, Alexander DB, Xu J, Tsuda H
Multiwalled carbon nanotubes intratracheally instilletd into the rat lung induce development of pleural malignant mesothelioma and lung tumors.
Cancer Sci 107(7):924-935, 2016. DOI:10.1111/cas.12954 - Inaba H, Goto H, Kasahara K, Kumamoto K, Yonemura S, Inoko A, Yamano S, Wanibuchi H, He D, Goshima N, Kiyono T, Hirotsune S, Inagaki M.
Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.
J Cell Biol. 212:409-423, 2016. DOI:10.1083/jcb.201507046 - Park S, Komatsu T, Kim SE, Tanaka K, Hayashi H, Mori R, Shimokawa I
Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction.
Aging Cell 16(2):339-348, 2016. DOI:10.1111/acel.12558 - Kitamura, T., Watanabe-Okochi, N., Enomoto, Y., Nakahara, F., Oki, T., Komeno, Y., Kato, N., Doki, N., Uchida, T., Kagiyama, Y., Togami, K., Kawabata, K.C., Nishimura, K., Hayashi, Y., Nagase, R., Saika, M., Fukushima, T., Asada, S., Fujino, T., Izawa, Y., Horikawa, S., Fukuyama, T., Tanaka, Y., Ono, R., Goyama, S., Nosaka, T., Kitaura, J., and Inoue D.
Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).
J Biol Chem. 159:17-25, 2016. DOI:10.1093/jb/mvv114 - Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A and Hikida T.
Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage.
Learning and Memory 23 (7):359-64, 2016. DOI:10.1101/lm.042507.116 - Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M,?Ohmuraya?M, Sato T, Yoshimura SI, Sato K, Harada R, Kim YJ, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A.
Opposing Roles for SNAP23 in Secretion in Exocrine and Endocrine Pancreatic Cells.
J Cell Biol. 215（1）:121-138, 2016. DOI:10.1083/jcb.201604030 - Chowdhury S, *Yamanaka A
Optogenetic activation of serotonergic terminals facilitates GABAergic inhibitory input to orexin/hypocretin neurons.
Scientific reports 6:36039, 2016. DOI:10.1038/srep36039 - Hisha H, and Ueno H.
Organoid Culture of Lingual Epithelial Cells in a Three-Dimensional Matrix.
Methods in molecular biology 1576:93-99, 2016. DOI:10.1007/7651_2016_3 - Toyokuni S
Oxidative stress as an iceberg in carcinogenesis and cancer biology.
Archives of Biochemistry and Biophysics 595:46-49, 2016. DOI:10.1016/j.abb.2015.11.025 - Duquesnes N., Callot C., Jeannot P., Daburon V., Nakayama KI., Manenti S., Davy A., Besson A.
p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith?Wiedemann syndrome.
J. Pathol. 239:250-61, 2016. DOI:10.1002/path.4721 - Saito, T., Waguri, S (38人中34番目)., *Komatsu, M (38人中38番目).
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.
Nat Commun 7, 2016. DOI:10.1038/ncomms12030 - Hatano A, Matsumoto M, Nakayama KI.
Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling.
Genes Cells 21:1095-112, 2016. DOI:10.1111/gtc.12406 - Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K.
Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons.
Mol. Cell 63:p1-12, 2016. DOI:10.1016/j.molcel.2016.06.008 - Umeda K, Ishizuka T, Yawo H, Shoji W.
Position- and quantity-dependent responses in zebrafish turning behavior.
Sci Rep. 6:27888, 2016. DOI:10.1038/srep27888 - Doi H, Kitajima Y, Luo L, Yan C, Tateishi S, Ono Y, Urata Y, Goto S, Mori R, Masuzaki H, Shimokawa I, Hirano A, Li TS
Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing.
Sci Rep 6:18844, 2016. DOI:10.1038/srep18844 - Lim, BC., Matsumoto, S., Yamamoto, H., Mizuno, H., Kikuta, J., Ishii, M., and Kikuchi, A
Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.
J. Cell Sci 129:3115-3129, 2016. DOI:10.1242/jcs.185439 - Guida V, Cernilogar FM, Filograna A, De Gregorio R, Ishizu H, Siomi MC, Schotta G, Bellenchi GC, Andrenacci D.
Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.
Genetics 204:631-644, 2016. DOI:10.1534/genetics.116.187922 - Honda T, Soeda S, Tsuda K, Yamaguchi C, Aoyama K, Morinaga T, Yuki R, Nakayama Y, Yamaguchi N, Yamaguchi N
Protective role for lipid modifications of Src-family kinases against chromosome missegregation.
Sci Rep.? 6:38751, 2016. DOI:10.1038/srep38751 - Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S.
Protein Kinase D Regulates Positive Selection of CD4 + Thymocytes Through Phosphorylation of SHP-1.
Nat Commun. 7:12756, 2016. DOI:10.1038/ncomms12756 - 8. Toda, S., Iguchi, Y., Lin, Z., Nishikawa. H, Nagasawa, T., Watanabe, H., & Minabe, Y.
Reconsidering animal models of major depressive disorder in the elderly.
Frontiers in Aging Neuroscience 8:188, 2016. DOI:10.3389/fnagi.2016.00188 - Fujieda Y., Amengual O., Matsumoto M., Kuroki K., Takahashi H., Kono M., Kurita T., Otomo K., Kato M., Oku K., Bohgaki T., Horita T., Yasuda S., Maenaka K., Hatakeyama S., Nakayama KI., Atsumi T.
Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.
Rheumatology 55:1117-26, 2016. DOI:10.1093/rheumatology/kew005 - Kuribayashi H, Tsuhako A, Kikuchi M, Yoshida N, Koso H, Watanabe S
Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina.
Exp. Eye Res. 152:34-42, 2016. DOI:10.1016/j.exer.2016.09.005 - Chin DW, Sakurai M, Nah GS, Du L, Jacob B, Yokomizo T, Matsumura T, Suda T, Huang G, Fu XY, Ito Y, Nakajima H, Osato M.
RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.
Blood Cancer J. 6:e379, 2016. DOI:10.1038/bcj.2015.105 - Watabe, A.M., Nagase, M., Hagiwara, A., Hida, Y., Tsuji, M., Ochiai, T., Kato, F., Ohtsuka, T.
SAD-B Kinase regulates presynaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory.
Journal of Neurochemistry 136(1):36-47, 2016. DOI:10.1111/jnc.13379 - Meisler MH, Helman G, Hammer MF, Fureman BE, Gaillard WD, Goldin AL, Hirose S, Ishii A, Kroner BL, Lossin C, Mefford HC, Parent JM, Patel M, Schreiber J, Stewart R, Whittemore V, Wilcox K, Wagnon JL, Pearl PL, Vanderver A, Scheffer IE.
SCN8A encephalopathy: Research progress and prospects.
Epilepsia 57(7):1027-1035, 2016. DOI:10.1111/epi.13422 - Kimiko Shimizu, Yodai Kobayashi, Erika Nakatsuji, Maya Yamazaki, Shigeki Shimba, Kenji Sakimura & Yoshitaka Fukada
SCOP/PHLPP1b mediates circadian regulation of long-term recognition memory.
Nature Communications 7:12926, 2016. DOI:10.1038/ncomms12926 - Jun J. Nakano, Kimiko Shimizu, Shigeki Shimba & Yoshitaka Fukada
SCOP/PHLPP1β in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior.
Scientific Reports 6:33500, 2016. DOI:10.1038/srep33500 - Yang H, Ni HM, Guo F, Ding Y, Shi YH, Lahiri P, Fr?hlich LF, R?licke T, Smole C, Schmidt VC, Zatloukal K, Cui Y, Komatsu M, Fan J, Ding WX.
Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice.
J Biol Chem. 291:18663-18674, 2016. DOI:10.1074/jbc.M116.739821 - Takamura, S., Yagi, H., Hakata, Y., Motozono, C., McMaster, SR., Tomura, M., Nakayama, T., Woodland, DL., Kohlmeier, JE., Miyazawa, M.
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
J Exp Med. 213:3057-3073, 2016. DOI:10.1084/jem.20160938 - Habisov, S., Huber, J., Ichimura, Y., Akutsu, M., Rogova, N., Loehr, F., McEwan, D.G., Johansen, T., Dikic, I., Doetsch, V., Komatsu, M., Rogov, V.V., *Kirkin, V.
Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.
J Biol Chem 291:9025-9041, 2016. DOI:10.100xxx2/ejoc.201601023 - Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, Nureki O.
Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.
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Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala.
Journal of Neurophysiology 115:2721-2739, 2016. DOI:10.1152/jn.00946.2015 - Yasuda D, Nakajima M, Yuasa A, Obata R, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.
Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity.
Bioorg Med Chem Lett 26:5956-5959, 2016. DOI:10.1016/j.bmcl.2016.10.083 - Katsushima K, Natsume A, Ohka F, Shinjo K, Hatanaka A, Ichimura N, Sato S, Takahashi S, Kimura H, Totoki Y, Shibata T, Naito M, Kim HJ, Miyata K, Kataoka K, Kondo Y.
Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment.
Nat Commun 7:13616-, 2016. DOI:10.1038/ncomms13616 - Fuchs H, Sabrautzki S, Przemeck G, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, O?stereicher M, Hans W, Abe K et al.
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.
G3・Genes| Genomes| Genetics 6:4035-4046, 2016. DOI:10.1534/g3.116.033670 - Inutsuka A, Yamashita A, Chowdhury S, Nakai J, Ohkura M, Taguchi T, *Yamanaka A
The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation.
Scientific reports 6:29480, 2016. DOI:10.1038/srep29480 - Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A.
The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.
J Exp Med 213(8):1459-1477, 2016. DOI:10.1084/jem.20151121 - Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S.
The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.
J. Mol. Cell. Cardiol. 100:43-53, 2016. DOI:10.1016/j.yjmcc.2016.09.013 - Toyokuni S
The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy.
Pathology International 66:245-259, 2016. DOI:10.1111/pin.12396 - Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C, Hirao A.
Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance.
J Biol Chem. 291:21496-21509, 2016. DOI:10.1074/jbc.M116.734756 - Takeishi S., Nakayama KI.
To wake up cancer stem cells, or to let them sleep, that is the question.
Cancer Sci. 107:875-81, 2016. DOI:10.1111/cas.12958 - Miyamoto D,?Hirai D,?Fung CC,?Inutsuka A,?Odagawa M,?Suzuki T,?Boehringer R,?Adaikkan C,?Matsubara C,?Matsuki N,?Fukai T,?McHugh TJ,Yamanaka A,?*Murayama M
Top-down cortical input during NREM sleep consolidates perceptual memory.
Science 352(6291):1315-1318, 2016. DOI:10.1126/science.aaf0902 - Eisuke Sato, Yurika Tanabe, Naoya Nakajima, Akifumi Ohkubo, and Kiyotake Suenaga
Total Synthesis of Biselyngbyolide B.
Organic Letters 18 (9):2047-2049, 2016. DOI:10.1021/acs.orglett.6b00660 - Ju J, Hirose S, Shi XY, Ishii A, Hu LY, Zou LP.
Treatment with Oral ATP decreases alternating hemiplegia of childhood with de novo ATP1A3 Mutation.
Orphanet Journal of Rare Diseases. 11(1):55, 2016. DOI:10.1186/s13023-016-0438-7 - Inoue, D., Nishimura, K., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K-I. and Kitamura, T
Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.
Experimental Hematology 44:172 -176, 2016. DOI:10.1016/j.exphem.2015.11.011 - Takaori T, Kumakura A, Ishii A, Hirose S, Hata D.
Two mild cases of Dravet syndrome with truncating mutation of SCN1A.
Brain & Development 39(1):72-74, 2016. DOI:10.1016/j.braindev.2016.07.006 - Takatoshi Iijima, Chiharu Hidaka and Yoko Iijima.
Update Article: Spatio-temporal regulations and functions of neuronal alternative RNA splicing in developing and adult brains.
Neuroscience Research. 109:43473, 2016. DOI:10.1016/j.neures.2016.01.010 - Matsunaga R, Nishino T, Yokoyama A, Nakashima A, Kikkawa U, Konishi H.
Versatile function of the circadian protein CIPC as a regulator of Erk activation.
Biochem Biophys Res Commun. :377-383, 2016. DOI:10.1016/j.bbrc.2015.11.117 - Abedini, A., Zamberlam, G., Lapointe, E., Tourigny, C., Boyer, A., Paquet, M., Hayashi, K., Honda, H., Kikuchi, A., Price, C., and Boerboom, D
WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
FASEB J 30(4):1534-1547, 2016. DOI:10.1096/fj.15-280313 - Matsumoto, S., Kurimoto, T., Taketo, M., Fujii, S., and Kikuchi, A
Wnt-Myb pathway suppresses KIT expression to control the timing of salivary proacinar differentiation and duct formation.
Development 143(13):2311-2324, 2016. DOI:10.1242/dev.134486 - 山中章弘
オレキシンを中心とした睡眠覚醒調節の神経機構.
高齢者の睡眠とその障害 :221-228, 2016. - 蛯原功介、山中章弘
オレキシン受容体の関連物質をターゲットとした臨床応用.
Clinical Neuroscience 34(7):740-741, 2016. - 山中章弘
オレキシン受容体の種類.
Clinical Neuroscience 34(5):496-497, 2016. - 山下貴之、山中章弘
オレキシン受容体の生理的および薬理的機能.
Clinical Neuroscience 34(6):612-613, 2016. - 小川宏人
昆虫の短中距離ナビゲーションを支える神経基盤.
日本ロボット学会誌 34:685-689, 2016. DOI:10.7210/jrsj.34.685 - 渡邉 貴樹, 上阪 直史, 狩野 方伸
生後発達期の小脳におけるシナプス刈り込みのメカニズム.
生化学 88(5):621-629, 2016. DOI:10.14952/SEIKAGAKU.2016.880621 - 山本一男
哺乳類の細胞サイズを規定する分子基盤.
実験医学 34(15):2615-2620, 2016.
