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成果論文リスト

本支援による成果を含む論文として支援依頼者から報告があった論文を発表の新しい順に並べました。成果論文には「先端モデル動物支援」の課題番号「16H06276」を謝辞に入れることをお願いしていますが、課題番号の記載がない論文も含めています。また、前事業「生命科学系3分野(がん・ゲノム・脳)支援活動」の支援を受けた成果のうち、そちらの課題番号のみが記載されたもの(*)も含まれています。

2018年度

  1. Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S. and Irie, K.
    Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin.
    Heterocycles 97(1):478-492, 2018. DOI:10.3987/COM-18-S(T)37
  2. Hirotaka Watanabe, et al.
    Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells.
    Cell Rep. 23:3721-3729, 2018. DOI:10.1016/j.celrep.2018.05.081
  3. 和田裕一, 三浦知志, 窪俊一
    マンガの読みにおける状況モデルの更新.
    マンガ研究 24:93-114, 2018.
  4. Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Ichikawa J, Osada M, Satoh K, Ozaki Y, Suzuki-Inoue K.
    Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis.
    J Thromb Haemost 16(5):960-972, 2018. DOI:10.1111/jth.13987
  5. Saito M, Ichikawa J, Ando T, Schoenecker JG, Ohba T, Koyama K, Suzuki-Inoue K, Haro H.
    Platelet-Derived TGF-β Induces Tissue Factor Expression via the Smad3 Pathway in Osteosarcoma Cells.
    J Bone Miner Res. 33(11):2048-2058, 2018. DOI:10.1002/jbmr.3537
  6. Takayama Y, Ando T, Ichikawa J, Haro H
    Effect of Thrombin-Induced MCP-1 and MMP-3 Production Via PAR1 Expression in Murine Intervertebral Discs.
    Sci. Rep 8(1):11320, 2018. DOI:10.1038/s41598-018-29669-z
  7. Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama S
    Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells.
    Sci. Rep. 8:6760, 2018. DOI:10.1038/s41598-018-25189-y
  8. Kamijo Y, Kawahara K, Yoshinaga T, Kurata H, Arima K, Furukawa T.
    A novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analyses.
    Oncoscience. 5:88-98, 2018. DOI:10.18632/oncoscience.411
  9. Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A.
    FEAT enhances INSL3 expression in testicular Leydig cells.
    Genes to cells 23:952-962, 2018. DOI:10.1111/gtc.12644
  10. Hideaki ABE, Manabu NATSUMEDA, Yu KANEMARU, Jun WATANABE, Yoshihiro TSUKAMOTO, Masayasu OKADA, Junichi YOSHIMURA, Makoto OISHI, and Yukihiko FUJII
    MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas.
    Neurol Med Chir (Tokyo) 58:290-295, 2018. DOI:10.2176/nmc.ra.2018-0044
  11. 岡田正康, 棗田学, 河嵜麻実, 大石誠, 藤井幸彦, 五十嵐道弘
    細胞突起形成抑制による膠芽腫治療戦略.
    新潟県医師会報 814(1):9-10, 2018.
  12. Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
    Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
    Neurosci Res.  in press, 2018. DOI:10.1016/j.neures.2018.08.016
  13. Saitoh F, Hagiwara H, Wakatsuki S, Araki T.
    Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency.
    Neurosci Res.  in press, 2018. DOI:10.1016/j.neures.2018.08.015
  14. Mori R, Tanaka K, Shimokawa I
    Identification and functional analysis of inflammation-related miRNAs in skin wound repair.
    Dev Growth Differ 60(6):306-315, 2018. DOI:10.1111/dgd.12542
  15. de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu To, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R
    Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds.
    EMBO Mol Med 10(10):e9024, 2018. DOI:10.15252/emmm.201809024
  16. Umehara T, Mori R, Mace K, Murase T, Abe Y, Yamamoto T, Ikematsu K
    Identification of specific microRNAs in neutrophils of type 2 diabetic mice: overexpression of microRNA-129-2-3p accelerates diabetic wound healing.
    Diabetes in press, 2019.
  17. Oikawa D, Shiota M, Wanibuchi H, Tokunaga F.
    Generation of rat monoclonal antibodies against a deubiquitinase, ovarian tumor domain-containing protein 1.
    Monoclon Antib Immunodiagn Immunother. 37(4):180-184, 2018. DOI:10.1089/mab.2018.0023
  18. Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
    High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System.
    SLAS Discovery 23(10):1018-1029, 2018. DOI:10.1177/2472555218793066
  19. Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O.
    Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
    Nature Commun. 9:4424, 2018. DOI:10.1038/s41467-018-06922-7
  20. Akatsuka S, Li GH, Toyokuni S
    Superiority of rat over murine model for studies on the evolution of cancer genome.
    Free Radical Research 7:1-5, 2018. DOI:10.1080/10715762.2018.1467562
  21. Toyokuni S
    Iron Addiction with Ferroptosis-resistance in Asbestos-induced Mesothelial Carcinogenesis: Toward the Era of Mesothelioma Prevention.
    Free Radical Biology & Medicine , 2019. DOI:10.1016/j.freeradbiomed.2018.10.401
  22. Okada K, Nishizawa K, Setogawa S, Hashimoto K, Kobayashi K.
    Task-dependent function of striatal cholinergic interneurons.
    Eur J Neurosci 47(10):1174-1183., 2018. DOI:10.1111/ejn.13768
  23. Kurihara Y, Makita Y, Kawashima M, Fujita T, Iwasaki S, and Matsui M.
    Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis.
    Proc Natl Acad Sci U S A. 115(30):7831-7836, 2018. DOI:10.1073/pnas.1804971115
  24. Taiwa K, Yokoi S, Mito M2, Fujii K, Kimura Y, Iwasaki S, Nakagawa S.
    UPA-Seq: Prediction of Functional LncRNAs Using Differential Sensitivity to UV Crosslinking.
    RNA 24(12):1785-1802., 2018. DOI:10.1261/rna.067611.118
  25. Akichika S., Hirano S., Shichino Y., Suzuki T., Nishimasu H., Ishitani R., Sugita A., Hirose Y., Iwasaki S., Nureki O., and Suzuki T.
    Cap-specific terminal N6-methylation of RNA by an RNA polymerase II-associated methyltransferase.
    Science , 2018. DOI:10.1126/science.aav0080
  26. Iwasaki S.*, Iwasaki W., Takahashi M., Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T.*, and Ingolia NT.*
    The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA.
    Mol. Cell 73:1–10, 2019. DOI:10.1016/j.molcel.2018.11.026
  27. Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
    Generation of Rat Monoclonal Antibodies Specific for DZIP3.
    Monoclon Antib Immunodiagn Immunother. 37:153-157, 2018. DOI:10.1089/mab.2018.0005
  28. Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Shimizu A.
    In-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.
    J Dermatol Sci. 91:35-42, 2018. DOI:10.1016/j.jdermsci.2018.03.012
  29. Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
    High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time- Resolved Fluorescence (HTRF)-Based Assay System.
    SLAS Discov. 23:1018-1029, 2018. DOI:10.1177/2472555218793066
  30. Oikawa D, Shiota M, Goto E, Komakura K, Wanibuchi H, Tokunaga F.
    Generation of Rat Monoclonal Antibodies against a Deubiquitinase, OTUD1.
    Monoclon Antib Immunodiagn Immunother. 37:180-184, 2018. DOI:10.1089/mab.2018.0023
  31. Bando Y*, Sakamoto M* (Co-first and corresponding author), Kim S, Ayzenshtat I, Yuste R.
    Comparative evaluation of genetically encoded voltage indicators.
    Cell Rep. in press, 2019.
  32. Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N
    Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.
    Int J Mol Sci. 19(6):E1811, 2018. DOI:10.3390/ijms19061811
  33. Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N
    Forkhead box protein A1 confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.
    J Cell Biochem. in press, 2018. DOI:10.1002/jcb.27551
  34. Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
    Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.
    Oncogene in press, 2018. DOI:10.1038/s41388-018-0481-z
  35. Kurataka Otsuka, Yusuke Yamamoto, Takahiro Ochiya
    Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer.
    Oncotarget 9(37):24718-24730, 2018. DOI:10.18632/oncotarget.25339
  36. Miyasato Y, Yoshizawa T. et al.
    Sirtuin 7 deficiency ameliorates cisplatin-induced acute kidney injury through regulation of the inflammatory response.
    Sci. Rep 8:5927, 2018. DOI:10.1038/s41598-018-24257-7
  37. Fukuda M, Yoshizawa T. et al.
    SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
    Nat Commun 19:2833, 2018. DOI:10.1038/s41467-018-05187-4
  38. Yokoshima Y, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Kato R, Hozumi J, Abe H, Azuma K, Tsuchida R, Yamada Y, Japanese TR-Cancer Pain Research Group.
    Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain: An exploratory study.
    Neuropsychopharmacology Report in press, 2018. DOI:10.1002/npr2.12030
  39. Kokuda R, Watanabe R, Okuzaki D, Akamatsu H, Oneyama C.
    MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression.
    Genes Cells 23(8):688-701, 2018. DOI:10.1111/gtc.12610
  40. Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
    CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration.
    Neurochem Int 119:190-198, 2018. DOI:10.1016/j.neuint.2018.01.003
  41. Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.
    UBL3 modification influences protein sorting to small extracellular vesicles.
    Nature Commun. 9:3936, 2018. DOI:10.1038/s41467-018-06197-y
  42. Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H.
    Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
    Sci. Rep. 8:e14827, 2018. DOI:10.1038/s41598-018-33139-x
  43. Okazaki S, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Kinoshita M, Inoue E, Ohmori T, Someya T, Sora I.
    Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia.
    Prog Neuropsychopharmacol Biol Psychiatry 83:33-41, 2018. DOI:10.1016/j.pnpbp.2018.01.001
  44. Kimura A, Hishimoto A, Otsuka I, Okazaki S, Boku S, Horai T, Izumi T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
    Loss of chromosome Y in blood, but not in brain, of suicide completers.
    PLoS One. 13(1):e0190667, 2018. DOI:10.1371/journal.pone.0190667
  45. Eguchi N, Sora I, Muguruma K.
    Self-organizing cortex generated from human iPSCs with combination of FGF2 and ambient oxygen.
    Biochem Biophys Res Commun. 498(4):729-735, 2018. DOI:10.1016/j.bbrc.2018.03.049
  46. Zhang Y, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Yamamori H, Boku S, Horai T, Someya T, Ohmori T, Hashimoto R, Sora I
    Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population.
    J Psychiatr Res. 103:161-166, 2018. DOI:10.1016/j.jpsychires.2018.05.014
  47. Horai T, Hishimoto A, Otsuka I, So T, Mouri K, Shimmyo N, Boku S, Okishio N, Sora I.
    A cross-sectional study exploring useful indicators for low bone mineral density in male alcoholic patients.
    Neuropsychiatr Dis Treat 14:663-669, 2018. DOI:10.2147/NDT.S153360
  48. Yu Chen, Masahiro Takikawa, Shuichi Tsutsumi, Yoko Yamaguchi, Atsushi Okabe, Mayuna Shibata, Tatsuya Kawase, Akane Sada, Issei Ezawa, Yuhei Takano, Kisaburo Nagata, Yutaka Suzuki, Kentaro Semba, Hiroyuki Aburatani, Rieko Ohki.
    PHLDA1, another PHLDA family protein that inhibits Akt.
    Cancer Sci. 109:3532-3542, 2018. DOI:10.1111/cas.13796
  49. Nakatsumi H., Oka T., Higa T., Shirane M., Nakayama KI.
    Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1.
    Genes Cells 23:599-605, 2018. DOI:10.1111/gtc.12597
  50. Kikuchihara S, Sugio S, Tanaka KF, Watanabe T, Kano M, Yamazaki Y, Watanabe M, Ikenaka K.
    Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice.
    J Neurochem 147(3):344-360, 2018. DOI:10.1111/jnc.14486
  51. Kano M, Watanabe T, Uesaka N, Watanabe M.
    Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum.
    Cerebellum. 17(6):722–734, 2018. DOI:10.1007/s12311-018-0964-z
  52. Ashida, Y., Yanagita, R. C., Kawanami, Y., Okamura, M., Dan, S. and Irie, K.
    Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin.
    Heterocycles in press
  53. Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H
    Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
    Sci. Rep 8(1):5435, 2018. DOI:10.1038/s41598-018-23810-8
  54. Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H
    Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo.
    J Physiol Sci :Epub ahead of print, 2018. DOI:10.1007/s12576-018-0618-4
  55. Asano T, Igarashi H, Ishizuka T, Yawo H
    Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light.
    Front Neurosci. 12:561, 2018. DOI:10.3389/fnins.2018.00561
  56. Shen YC, Sasaki T, Matsuyama T, Yamashita T, Shichida Y, Okitsu T, Yamano Y, Wada A, Ishizuka T, Yawo H, Imamoto Y.
    Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues.
    Biochemistry 57(38):5544-5556, 2018. DOI:10.1021/acs.biochem.8b00583
  57. Abe K, Yawo H.
    Quantitative study of the somatosensory sensitization underlying cross-modal plasticity.
    PLoS One. 13(12):e0208089, 2018. DOI:10.1371/journal.pone.0208089
  58. Tsuge M, Osaki M, Sasaki R, Hirahata M, Okada F
    SK-216, a novel inhibitor of plasminogen activator inhibitor-1, suppresses lung metastasis of human osteosarcoma.
    Int J Mol Sci 19(3):736, 2018. DOI:10.3390/ijms19030736
  59. Matsuyama S, Kage Y, Fujimoto N, Ushijima T, Tsuruda T, Kitamura K, Shiose A, Asada Y, Sumimoto H, Takeya R.
    Interaction between cardiac myosin-binding protein C and formin Fhod3.
    Proc Natl Acad Sci U S A. 115(19):E4386-E4395, 2018. DOI:10.1073/pnas.1716498115
  60. Vu HT, Kobayashi M, Hegazy AM, Tadokoro Y, Ueno M, Kasahara A, Takase Y, Nomura N, Peng H, Ito C, Ino Y, Todo T, Nakada M, Hirao A.
    Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas.
    Cancer Sci. 109:2497-2508, 2018. DOI:10.1111/cas.13695
  61. Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T.
    Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.
    Nature Commun. 9(1):2733, 2018. DOI:10.1038/s41467-018-05085-9
  62. Saika M, Inoue D, Nagase R, Sato N, Tsuchiya A, Yabushita T, Kitamura T, Goyama S.
    ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFb pathway genes through histone deacetylation.
    Sci. Rep. 8(1):15873, 2018. DOI:10.1038/s41598-018-33881-2
  63. Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T
    Deficiency of AMPA receptor-palmitoylation aggravates seizure susceptibility.
    J Neurosci 38:10220-10235, 2018. DOI:10.1523/JNEUROSCI.1590-18.2018
  64. Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T
    Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation deficient mice.
    Neuropsychopharmacology Reports , 2018. DOI:10.1002/npr2.12044
  65. Nakashima C, Yamamoto K, Fujiwara-Tani R, Luo Y, Matsushima S, Fujii K, Ohmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H
    Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.
    Cancer Sci. 109(6):2036-2045, 2018. DOI:10.1111/cas.13594
  66. Sasahira T, Nishiguchi Y, Kurihara-Shimomura M, Nakashima C, Kuniyasu H, Kirita T.
    NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma.
    J Cancer Res Clin Oncol 144(5):875-882, 2018. DOI:10.1007/s00432-018-2612-x
  67. Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H, Kirita T.
    The multifarious functions of pyruvate kinase M2 in oral cancer cells.
    Int J Mol Sci 19(10), 2018. DOI:10.3390/ijms19102907
  68. Matsushima-Otsuka S, Fujiwara-Tani R, Sasaki T, Ohmori H Nakashima C, Kishi S, Nishiguchi Y, Fujii K, Luo Y, Kuniyasu H
    Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma.
    Oncotarget 9(93):36561-36574, 2018. DOI:10.18632/oncotarget.26337
  69. Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Nishiguchi Y, Kishi S, Mori S, Goto K, Kondoh M, Kuniyasu H
    Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer.
    Oncotarget in press, 2018.
  70. Hashimoto Y, Hata T, Tada M, Iida M, Watari A, Okada Y, Doi T, Kuniyasu H, Yagi K, Kondoh M
    Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2.
    Eur J Pharm Sci 117:161-167, 2018. DOI:10.1016/j.ejps.2018.02.016
  71. Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
    Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy.
    Pathobiology in press, 2018.
  72. Miyagawa Y, Mori T, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Ohmori H, Kawahara I, Kuniyasu H
    Intake of medium-chain fatty acids induces oxidative stress and to atrophy the myocardium.
    Lipids in Health and Disease 17:258, 2018. DOI:10.1186/s12944-018-0908-0
  73. Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, Ríos A, Kawabata M, Kimura M, Sakai Y, *Isomura Y
    Area-specific modulation of functional cortical activity during block-based and trial-based proactive inhibition.
    Neuroscience 388:297-316, 2018. DOI:10.1523/JNEUROSCI.1584-18.2018
  74. Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, *Isomura Y, *Kimura M
    Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways.
    Neuron 99(6):1302-1314, 2018. DOI:10.1016/j.neuron.2018.08.002
  75. *Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, Ríos A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y
    Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.
    J Neurosci , 2018. DOI:10.1523/JNEUROSCI.1584-18.2018
  76. Wang C, Oshima M, Sato D, Matsui H, Kubota S, Aoyama K, Nakajima-Takagi Y, Koide S, Matsubayashi J, Mochizuki-Kashio M, Nakano-Yokomizo T, Bai J, Nagao T, Kanai A, Iwama A, Sashida G.
    Ezh2 loss propagates hypermethylation at T-cell differentiation-regulating genes to promote leukemic transformation.
    J Clin Invest 128(9):3872-86, 2018. DOI:10.1172/JCI94645
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    Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.
    iScience 9:161-174, 2018. DOI:10.1016/j.isci.2018.10.008
  78. Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger G, Wang J, Dong Y, Zhou Y, Wang J, Wu LY, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, et al.
    Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
    Cancer Discovery 8(11):1438-57, 2018. DOI:10.1158/2159-8290.CD-17-1203
  79. Ito N., Mohammad B., A., Shah A., I., A., and *Ohta K.
    Transdifferentiation of human somatic cells by ribosome.
    Dev Growth Differ. 60:241-247, 2018. DOI:10.1111/dgd.12538
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    An extracellular [NiFe] hydrogenase mediating iron corrosion is encoded in a genetically unstable genomic island in Methanococcus maripaludis.
    Scientific Reports 8 8:15149, 2018. DOI:10.1038/s41598-018-33541-5
  81. Ohta K, Aoyama E, Ahmad SAI, Ito N, Anam MB, Kubota S, Takigawa M
    CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.
    J Cell Commun Signal. , 2018. DOI:10.1007/s12079-018-0487-x
  82. Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
    Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output.
    Cell Rep. 25:2704-2715, 2018. DOI:10.1016/j.celrep.2018.11.016
  83. Tsukahara, R., Yamamoto, S., Yoshikawa, K., Gotoh, M., Tsukahara, T., Neyama, H., Ishii, S., Akahoshi, N., Yanagida, K., Sumida, H., Araki, M., Araki, K., Yamamura, K. I., Murakami-Murofushi, K., Ueda, H.
    LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.
    J Pharmacol.Sci. 136:93-96, 2018. DOI:10.1016/j.jphs.2018.01.001
  84. Sumiyoshi K, Koso H, Watanabe S.
    Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma.
    Cancer Sci. 109(5):1513-1523, 2018. DOI:10.1111/cas.13579
  85. Koso H, Nishinakamura R, Watanabe S
    Sall1 regulates microglial morphology cell autonomously in the developing retina.
    Adv Exp Med Biol :209-215, 2018. DOI:10.1007/978-3-319-75402-4_26
  86. Kawamura Y, Yamanaka K, Poh B, Kuribayashi H, Koso H, Watanabe S
    The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development.
    Biochem Biophys Res Commun. 503(4):3023-3030, 2018. DOI:10.1016/j.bbrc.2018.08.088
  87. M. Ishido*
    An Overview of Development of Quantitative Neurotoxicity Testing In vitro.
    J Applied Life Sci Intl. 19:2394-1103, 2018. DOI:10.9734/JALSI/2018/45377
  88. M. Ishido*
    The temporal turning window for rat behavioral phenotypes by rotenone.
    Fund. Toxicol. Sci. 5:195-202, 2018. DOI:10.2131/fts.5.195
  89. Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrian Marchand, Fernaldo Richtia Winnerdy, Valerie Gabelica, Anh Tuan Phan, Masato Katahira & Kazuo Nagasawa
    Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound.
    ChemBioChem 19:2268-2272, 2018. DOI:10.1002/cbic.201800425
  90. Yue Ma, Yamato Tsushima, Mai Sakuma, Shogo Sasaki, Keisuke Iida, Sachiko Okabe, Hiroyuki Seimiya, Takatsugu Hirokawa, Kazuo Nagasawa
    Development of G-quadruplex ligand for selective induction of parallel-type topology.
    Org. Biomol. Chem. 16:7375-7382, 2018. DOI:10.1039/C8OB01702F
  91. Shadi Sedghi Masoud, Kazuo Nagasawa
    i-Motif-binding ligand and their effects on the structure and biological functions of i-motif.
    Chem. Pharm. Bull. 66:1091-1103, 2018. DOI:10.1248/cpb.c18-00720
  92. Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
    RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
    Cancer Sci. in press, 2018. DOI:10.1111/cas.13805
  93. Tominaga, K., Minato, H., Murayama, T., Sasahara, A., Nishimura, T., Kiyokawa, E., Kanauchi, H., Shimizu, S., Sato, A., Nishioka, K., Tsuji, E., Yano, M., Ogawa, T., Ishii, H., Mori, M., Akashi, K., Okamoto, K., Tanabe, M., Tada, K., Tojo, A., Gotoh, N.
    Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.
    Proc Natl Acad Sci U S A. in press, 2018.
  94. Tamari, K., Konno, M., Asai, A., Koseki., Jun., Hayashi, K., Kawamoto, K., Murai, N., Matsufuji, S., Isohashi, F., Satoh, T., Goto, N., Tanaka, S., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
    Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells.
    Cell Death Discovery 4(104), 2018. DOI:10.1038/s41420-018-0117-7
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    A Convolutional Neural Network Uses Microscopic Images to Differentiate between Mouse and Human Cell Lines and Their Radioresistant Clones.
    Cancer Res 78, 2018. DOI:10.1158/0008-5472.CAN-18-0653
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    Poly(ethylene glycol)–poly(lysine) block copolymer–ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.
    Oncogene , 2018. DOI:10.1038/s41388-018-0406-x
  97. Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
    Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
    J Clin Invest 128(12):5603-5619, 2018. DOI:10.1172/JCI121679
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    Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.
    Cerebral Cortex in press, 2018. DOI:10.1093/cercor/bhy253
  99. Ida-Yonemochi H, Morita W, Sugiura N, Kawakami R, Morioka Y, Takeuchi Y, Sato T, Shibata S, Watanabe H, Imamura T, Igarashi M, Ohshima H, Takeuchi K
    Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.
    Sci. Rep 8:17134-, 2018. DOI:10.1038/s41598-018-35412-5
  100. Yukawa T, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi, M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa S, Takeuchi R, Takahashi H, Kakita A, Someya T, *Nawa H
    Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia.
    Psychiarty Res 270:940-946, 2018. DOI:10.1016/j.psychres.2018.10.062
  101. Adhikara IM, *Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata K, Emoto N
    Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.
    Biochem Biophys Res Commun. 509(1):89-95, 2019. DOI:10.1016/j.bbrc.2018.12.068
  102. Brew N, Nakamura S, Hale, N. Azhan, A., Davies, G. I., Nitsos, I., Miller, S. L., Walker, D. W., Wong, F. Y.
    Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia.
    Pediatr Res 83(3):442-450, 2018. DOI:10.1038/s41390-018-0045-5
  103. Yamauchi Y., Itoh S. et al.
    HipOP mesenchymal population has high potential for repairing injured peripheral nerves.
    J Cell Biochem. 119(6):4836-4844, 2018. DOI:10.1002/jcb.26684
  104. Takeuchi Y., Kito A. et al.
    Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling.
    Exp. Cell Res. 371(2):417-425, 2018. DOI:10.1016/j.yexcr.2018.09.002
  105. Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR.
    Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.
    Cell Rep. 24:2196-2210, 2018. DOI:10.1016/j.celrep.2018.07.056
  106. Shiori Miura, Yoshitaka Maeda, Jun Miyamoto, Ena Nakatsukasa, Nobuyoshi Fujisawa, Miki Miwa, Katsuki Nakamura, Kenji Sakimura and Toshikuni Sasaoka
    Generation of functional oocytes of common marmoset by xeno-transplantation of ovarian tissue.
    Proceedings of International Symposium on Animal Production and Conservation for Sustainable Development 2018 :31-33, 2018.
  107. Michael S Nahorski, Sateesh Maddirevula, Ryosuke Ishimura, Saud Alsahli, Angela Brady, Anaïs Begemann, Tsunehiro Mizushima, Francisco J. Guzmán-Vega, Miki Obata, Yoshinobu Ichimura, Hessa S Alsaif, Shams Anazi, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Dorota Monies, Mohamed Abouelhoda, Brian F Meyer, Majid Alfadhel, Wafa Eyaid, Markus Zweier Katharina Steindl, Anita Rauch, Stefan T. Arold, *C Geoffrey Woods, *Masaaki Komatsu, *Fowzan S Alkuraya.
    Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.
    Brain 141:1934-1945, 2018. DOI:10.1093/brain/awy135
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    Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.
    Front Oncol. 8, 2018. DOI:10.3389/fonc.2018.00210
  109. Zhou L, Hossain MI, Yamazaki M, Abe M, Natsume R, Konno K, Kageyama S, Komatsu M, Watanabe M, Sakimura K, Takebayashi H.
    Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype.
    J Neurochem. 147:557-572, 2018. DOI:10.1111/jnc.14591
  110. Sánchez-Martín P, Komatsu M.
    p62/SQSTM1 - steering the cell through health and disease.
    J Cell Sci. 131, 2018. DOI:10.1242/jcs.222836
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    USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis.
    iScience. 9:433-450, 2018. DOI:10.1016/j.isci.2018.11.006
  112. Sánchez-Martín P, Saito T, Komatsu M.
    p62/SQSTM1: 'Jack of all trades' in health and cancer.
    FEBS J. , 2018. DOI:10.1111/febs.14712
  113. Someya, M. and Ogawa, H.
    Multisensory enhancement of burst activity in an insect auditory neuron.
    J Neurophysiol. 120:139-148., 2018. DOI:10.1152/jn.00798.2017
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    Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals.
    Advanced Robotics in press, 2019.
  115. Tatsunori Nishimura, Asuka Nakata, Xiaoxi Chen, Kurumi Nishi, Makiko Meguro-Horike, Soichiro Sasaki, Kenji Kita, Shin-ichi Horike, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Takahiko Murayama, Susumu Kohno, Chiaki Takahashi, Naofumi Mukaida, Seiji Yano, Tomoyoshi Soga, Arinobu Tojo, Noriko Gotoh
    Mthfd2の研究.
    Oncogene in press, 2018. DOI:10.1038/s41388-018-0589-1
  116. Ng IK, Lee J, Ng C, Kosmo B, Chiu L, Seah E, Mok MMH, Tan K, Osato M, Chng WJ, Yan B, Tan LK.
    Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation.
    Biomark Res. 6:16, 2018. DOI:10.1186/s40364-018-0130-2
  117. Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
    Systematic review of pre-clinical chronic myeloid leukaemia.
    Int J Hematol. 108(5):465-484, 2018. DOI:10.1007/s12185-018-2528-x
  118. Koide H, Shiga A, Komai E, Yamato A, Fujimoto M, Tamura A, Kono T, Nakayama A, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Suzuki S, Takeda Y, Shibuya M, Nishioka H, Yamada S, Inoshita N, Ishiwatari N, Horiguchi K, Yokote K, Tanaka T.
    Prednisolone-responsive Postpartum IgG4-related Hypophysitis.
    Intern Med. 57(3):367-375, 2018. DOI:10.2169/internalmedicine.8446-16
  119. Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
    Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women: Chiba bone survey.
    Endocr J. 65(2):193-202, 2018. DOI:10.1507/endocrj.EJ17-0331
  120. Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Miyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T.
    Glucagonoma With Necrolytic Migratory Erythema: Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.
    J Clin Endocrinol Metab. 103(7):2417-2423, 2018. DOI:10.1210/jc.2017-02646
  121. Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi Y, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T.
    p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells.
    Proc Natl Acad Sci U S A. 115(33):8370-8375, 2018. DOI:10.1073/pnas.1804243115
  122. Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
    Resting-state functional connectivity analysis of the mouse brain using intrinsic optical signal imaging of cerebral blood volume dynamics.
    Physiological Measurement 39:054003, 2018. DOI:10.1088/1361-6579/aac033
  123. 外川 龍之介, 奥畑 大悟, 吉田 侑冬,中尾 光之, 片山 統裕
    眼位・瞳孔径変動を考慮した内因性光信号イメージングに基づく覚醒時マウス脳視野地図の推定.
    生体医工学 in press, 2018.
  124. Maeda A, Nishino T, Matsuzaki R, Yokoyama A, Suga H, Yagi T, Konishi H.
    Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling.
    Biochim Biophys Acta Mol Cell Res. 1866:285-295, 2018. DOI:10.1016/j.bbamcr.2018.11.009
  125. Kikuchi K, Kozuka-Hata H, Oyama M, Seiki M & Koshikawa N
    Identification of proteolytic cleavage sites of EphA2 by membrane type-1 matrix metalloproteinase on the surface of cancer cells.
    Methods in Molecular Biology 1731:29-37, 2018. DOI:10.1007/978-1-4939-7595-2_3
  126. Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ.
    Study on the tumor-induced angiogenesis using mathematical models.
    Cancer Sci. 109:15-23, 2018. DOI:10.1111/cas.13395
  127. Takahashi Y, Hamasaki M, Aoki M, Koga K, Koshikawa N, Miyamoto S, Nabeshima K.
    Activated EphA2 processing by MT1-MMP is involved in malignant transformation of ovarian tumours in vivo.
    Anticancer Res 38:4257-4266, 2018. DOI:10.21873/anticanres.12722
  128. Okumura K, Saito M, and Wakabayashi Y.
    The role of PTH in mouse skin tumorigenesis.
    Integrative Cancer Science and Therapeutics 5:2, 2018. DOI:10.15761/ICST.1000271
  129. Aoto Y, Okumura K, Hachiya T, Hase S, Sato K, Wakabayashi Y, Ishikawa F and Sakakibara Y.
    Prospective study of the tumorigenesis process with an experimental carcinogenesis model.
    Sci. Rep. 8(1):12994, 2018. DOI:10.1038/s41598-018-31349-x
  130. Huizi Li, Aya Sugyo, Atsushi Tsuji, Yukie Morokoshi, Katsuyuki Minegishi, Kotaro Nagatsu, Hiroaki Kanda, Yosuke Harada, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Tatsuya Higashi, Sumitaka Hasegawa
    α-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibody against frizzled homolog 10.
    Cancer Sci. 109(7):2302-2309, 2018. DOI:10.1111/cas.13636
  131. Noguchi K, Konno M, Eguchi H, Kawamoto K, Mukai R, Nishida N, Koseki J, Wada H, Akita H, Satoh T, Marubashi S, Nagano H, Doki Y, Mori M, Ishii H.
    c-Met affects gemcitabine resistance during carcinogenesis in a mouse model of pancreatic cancer.
    Oncol Lett 16(2):1892-1898, 2018. DOI:10.3892/ol.2018.8793
  132. Takeuchi E, Ito-Ishida A, Yuzaki M, Yanagihara D.
    Improvement of cerebellar ataxic gait by injecting Cbln1 into the cerebellum of cbln1-null mice.
    Sci. Rep. 8(1):6184, 2018. DOI:10.1038/s41598-018-24490-0
  133. Ito-Ishida A, Yamalanchili HK, Shao Y, Baker SA, Heckman LD, Lavery LA, Kim JY, Lombardi LM, Sun Y, Liu Z, Zoghbi HY.
    Genome-wide distribution of linker histone H1.0 is independent of MeCP2.
    Nature Neuroscience 21(6):794-798, 2018. DOI:10.1038/s41593-018-0155-8
  134. Aoto Y, Okumura K, Hachiya T, Hase S, Wakabayashi Y, Ishikawa F, Sakakibara Y.
    Time-Series Analysis of Tumorigenesis in a Murine Skin Carcinogenesis Model.
    Sci. Rep. 8(1):12994, 2018. DOI:10.1038/s41598-018-31349-x
  135. Zhang Y, Nakano D, Guan Y, Hitomi H, Masaki T, Kobara H, Sugaya Y, Nishiyama A.
    A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice.
    Kidney Int. 94(3):524-535., 2018. DOI:10.1016/j.kint.2018.05.002
  136. Miyazawa, Y., Takahashi, Y., Watabe, A.M. and Kato F.
    Predominant synaptic potentiation and activation of the right central amygdala are independent of bilateral paracrachial activation in the hemilateral trigeminal inflammatory pain model of rats.
    Molecular Pain :14:1744806918807102, 2018. DOI:10.1177/1744806918807102
  137. Nagase, M., Mikami, K., and Watabe, A.M.# (#責任著者)
    Parabrachial-to-amygdala control of aversive learning.
    Current Opinion in Behavioral Sciences in press, 2019.
  138. Futakuchi M, Nitanda T, Ando S, Matsumoto H, Yoshimoto E, Fukamachi K, Suzui M
    Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment.
    Int J Mol Sci 19(3), 2018. DOI:10.3390/ijms19030888
  139. Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H
    Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes.
    Chem Res Toxicol 31(10):1025-1031, 2018. DOI:10.1021/acs.chemrestox.8b00067
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    Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglets.
    Brain Dev 40(8):649-661, 2018. DOI:10.1016/j.braindev.2018.04.010

2017年度

  1. Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI.
    Thymidine Catabolism as a Metabolic Strategy for Cancer Survival.
    Cell Rep. 19:1313-1321, 2017. DOI:10.1016/j.celrep.2017.04.061
  2. Furukawa T, Tabata S, Yamamoto M, Kawahara K, Shinsato Y, Minami K, Shimokawa M, Akiyama SI
    Thymidine phosphorylase in cancer aggressiveness and chemoresistance.
    Pharmacol Research 132:15-20, 2018. DOI:10.1016/j.phrs.2018.03.019
  3. 河原康一、古川龍彦
    核小体によるp53制御とがん治療薬開発の新展開.
    実験医学 35:2365-2367, 2017.
  4. Yuichiro Yoneoka, Junichi Yoshimura, Masayasu Okada, Yukihiko Fujii:
    Perifocal Inflammatory Reaction with Volume Fluctuation Caused by Diagnostic Radiation-Induced Reduction in Germinoma Makes Histological Diagnosis Difficult despite Its Disappearance following Treatment: A Significant Pitfall and Countermeasures to It.
    Pediatr Neurosurg. 52:87-92, 2017. DOI:10.1159/000450583
  5. Yuichiro Yoneoka, Junichi Yoshimura, Masakazu Sano, Masayasu Okada, Akiyoshi Kakita, Yukihiko Fujii
    Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement.
    Pediatr Neurosurg. 53(1):49-54, 2017. DOI:10.1159/000480021
  6. Hideko Ohno, Yuichiro Yoneoka, Shinya Jinguji, Naoto Watanabe, Masayasu Okada, Yukihiko Fujii
    Has acromegaly been diagnosed earlier?.
    J Clin Neurosci. 48:138-142, 2017. DOI:10.1016/j.jocn.2017.10.086
  7. Yuichiro Yoneoka, Masayasu Okada, Naoto Watanabe, Satoru Aoki, Akiyoshi Kakita, Yukihiko Fujii
    Ectopic pituitary null cell adenoma arising from the infundibulum in the third ventricle: A successful endonasal transsphenoidal resection after long-term follow-up MR imaging – A technical note.
    Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 10:122-125, 2017. DOI:10.1016/j.inat.2017.08.004
  8. Manabu Natsumeda, Kunio Motohashi, Hironaka Igarashi, Takanori Nozawa, Hideaki Abe, Yoshihiro Tsukamoto, Ryosuke Ogura, Masayasu Okada, Tsutomu Kobayashi, Hiroshi Aoki, Hitoshi Takahashi, Akiyoshi Kakita, Koichiro Okamoto, Tsutomu Nakada, Yukihiko Fujii
    Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy.
    Neurosurg Rev 41(2):641-647, 2018. DOI:10.1007/s10143-017-0908-y
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    CENP-R acts bilaterally as a tumor suppressor and an oncogene in the two-stage skin carcinogenesis model.
    Cancer Sci. 108(11):2142-2148, 2017. DOI:10.1111/cas.13348
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    The parathyroid hormone regulates skin tumour susceptibility in mice.
    Sci. Rep. 7 (1):11208, 2017. DOI:10.1038/s41598-017-11561-x
  166. Yamaki N, Hishimoto A, Otsuka I, Sasada T, Boku S, Saito T, Yasuda Y, Yamamori H, Ikeda M, Sora I, Iwata N, Hashimoto R
    Optimizing outcomes in clozapine rechallenge following neutropenia using human leukocyte antigen typing: A case report.
    Psychiatry Clin Neurosci. 71(4):289-290, 2017. DOI:10.1111/pcn.12505
  167. Yokose, J., Okubo-Suzuki, R., Nomoto, M., Ohkawa, N., Nishizono, H., Suzuki, A., Matsuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A.M., Sasahara, M., Kato, F., Inokuchi, K.
    Overlapping memory trace indispensable for linking, but not recalling, individual memories.
    Science 355(6323):398-403, 2017. DOI:10.1126/science.aal2690
  168. Shinohara K., Watabe, A.M. # , Nagase M., Okutsu Y., Takahashi Y., Kurihara H., Kato F.(#責任著者)
    Essential Role of Endogenous Calcitonin Gene-Related Peptide in Pain-associated Plasticity in the Central Amygdala.
    European Journal of Neuroscience 46(6):2149-2160, 2017. DOI:10.1111/ejn.13662
  169. Nobuhiko Takai, Masatsugu Ohgami, Koichi Ando, Akiko Uzawa, Ryoichi Hirayama, Saori Nakamura, Yoshihito Ohba
    THE FOCAL BRAIN IRRADIATION OF PROTON BEAM INSULT IN RATS INDUCED MEMORY DISTURBANCE RELATED CHANGE IN ACETYLCHOLINE RECEPTOR BINDING.
    RadProc vol.2:25-29., 2017. DOI:10.21175/RadProc.2017.06
  170. Masatsugu Ohgami, Nobuhiko Takai , Masahiko Watanabe, Koichi Ando, Akiko Uzawa, Ryoichi Hirayama
    EFFECT OF N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST ON RADIATION-INDUCED GUT INJURIES IN MICE.
    RadProc vol.2:6-10, 2017. DOI:10.21175/RadProc.2017.02
  171. Takano, T., Motozono, C., Imai, T., Sonoda, KH., Nakanishi, Y., Yamasaki, S.
    Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity.
    J Biol Chem. 292(41):16933-16941, 2017. DOI:10.1074/jbc.M117.800847
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    Microenvironmental control of breast cancer subtype elicited by paracrine platelet derived growth factor-CC signaling.,.
    Nat. Med. 24(4):463-473, 2018. DOI:10.1038/nm.4494
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    High-sensitivity detection of micrometastases in GFP-labelled colon tumor organoids extracted from patient-derived tumor xenografts.
    J Vis Exp. 14:136, 2018. DOI:10.3791/57374
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    The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
    Oncogene 37(9):1205-1219, 2018. DOI:10.1038/s41388-017-0033-y
  175. Nakaoka HJ, Tanei Z, Hara T, Weng JS, Kanamori A, Hayashi T, Sato H, Orimo A, Otsuji K, Tada K, Morikawa T, Sasaki T, Fukayama M, Seiki M, Murakami Y, Sakamoto T.
    Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth.
    Oncogenesis. 6:e334, 2017. DOI:10.1038/oncsis.2017.27
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    Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.,.
    Respir Res. 18:46, 2017. DOI:10.1186/s12931-017-0529-6
  177. Ogura H, Nagatake-Kobayashi Y, Adachi J, Tomonaga T, Fujita N, Katayama R
    TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity.
    Sci Rep 7(1):5519, 2017. DOI:10.1038/s41598-017-05736-9
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    Tyrosine Phosphorylation of the Pioneer Transcription Factor FoxA1 Promotes Activation of Estrogen Signaling.
    J Cell Biochem 118:1453-1461, 2017. DOI:10.1002/jcb.25804
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    Down-regulation of Forkhead Box Protein A1 (FOXA1) Leads to Cancer-stem Cell-like Properties in Tamoxifen-resistant Breast Cancer Cells through Induction of Interleukin-6.
    J Biol Chem 292:8136-8148, 2017. DOI:10.1074/jbc.M116.763276
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    Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis.
    World J Gastroenterol 23:1586-1593, 2017. DOI:10.3748/wjg.v23.i9.1586
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    Pro-metastatic intracellular signaling of the elaidic trans fatty acid.
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    Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells.
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    Fatty acids inhibit anti-cancer effect of 5-fluorouracil in mouse cancer cell lines.
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    Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed proliferation of CT26 mouse colon cancer cells.
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    Cerebral haemodynamic response to somatosensory stimulation in neonatal lambs.
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    Cerebral haemodynamic response to somatosensory stimulation in fetal sheep.
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    Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes.
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2016年度

  1. Moinuddin FM, Shinsato Y, Komatsu M, Mitsuo R, Minami K, Yamamoto M, Kawahara K, Hirano H, Arita K, Furukawa T
    ATP7B expression confers multidrug resistance through drug sequestration.
    Oncotarget 7:22779-90, 2016. DOI:10.18632/oncotarget.8059
  2. Tanabe K, Shinsato Y, Furukawa T, Kita Y, Hatanaka K, Minami K, Kawahara K, Yamamoto M, Baba K, Mori S, Uchikado Y, Maemura K, Tanimoto A, Natsugoe S
    Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
    Oncotarget 8:6353-6363, 2017. DOI:10.18632/oncotarget.14087
  3. Katamura, T.; Shimizu, T.; Mutoh, Y.; Saito, S.
    Synthesis of Tricyclic Benzazocines by Aza-Prins Reaction.
    Organic Letters 19(1):266-269, 2017. DOI:10.1021/acs.orglett.6b03577
  4. Doi H, Kitajima Y, Luo L, Yan C, Tateishi S, Ono Y, Urata Y, Goto S, Mori R, Masuzaki H, Shimokawa I, Hirano A, Li TS
    Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing.
    Sci. Rep 6:18844, 2016. DOI:10.1038/srep18844
  5. Pei W Tanaka K, Huang SC, Xu L, Liu B, Sinclair J, Idol J, Varshney GK, Huang H, Lin S, Nussenblatt RB, Mori R, Burgess SM
    Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation.
    NPJ Regen Med 1:16013, 2016. DOI:10.1038/npjregenmed.2016.13
  6. Park S, Komatsu T, Kim SE, Tanaka K, Hayashi H, Mori R, Shimokawa I
    Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction.
    Aging Cell 16(2):339-348, 2016. DOI:10.1111/acel.12558
  7. Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T, Yamaoka S.
    A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.
    Leukemia 30(3):716-727, 2016. DOI:10.1038/leu.2015.267
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    Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
    Nature Commun. 7:12547, 2016. DOI:10.1038/ncomms12547
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    HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.
    PLoS Pathogens 13:e100162, 2017. DOI:10.1371/journal.ppat.1006162
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    Reduced SHARPIN and LUBAC formation may contribute to CCl4- or acetaminophen-induced liver cirrhosis in mice.
    International Journal of Molecular Sciences 18:326, 2017. DOI:10.3390/ijms18020326
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    Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.
    Biochem Biophys Res Commun. 485:152-159, 2017. DOI:10.1016/j.bbrc.2017.02.040
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    Oxidative stress as an iceberg in carcinogenesis and cancer biology.
    Arch Biochem Biophys. 595:46-49, 2016. DOI:10.1016/j.abb.2015.11.025
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    The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy.
    Pathology International 66:245-259, 2016. DOI:10.1111/pin.12396
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    Coordinated Movement of Vesicles and Actin Bundles during Nerve Growth Revealed by Superresolution Microscopy.
    Cell Rep. 18(9):2203-2216, 2017. DOI:10.1016/j.celrep.2017.02.008
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    Vesicular movements in the growth cone.
    Neurochemistry International 119:71-76, 2018. DOI:10.1016/j.neuint.2017.09.011
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    Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase.
    Journal of the American Chemical Society 140(38):12189-12199, 2018. DOI:10.1021/jacs.8b07339
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    Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian.
    Dev. Cell 37:226-37., 2016. DOI:10.1016/j.devcel.2016.04.009
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    Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons.
    Mol. Cell 63:p1-12, 2016. DOI:10.1016/j.molcel.2016.06.008
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    Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells.
    Genes Dev. 30:1617-1622., 2016. DOI:10.1101/gad.283929.116
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    Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.
    Genetics 204:631-644, 2016. DOI:10.1534/genetics.116.187922
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    Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA.
    Cell 167:484-497, 2016. DOI:10.1016/j.cell.2016.09.002
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    Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.
    Sci. Rep 6:34756 , 2016. DOI:10.1038/srep34756
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    Chemical labeling for visualizing native AMPA receptors in live neurons.
    Nature Commun. 8:e14850, 2017. DOI:10.1038/ncomms14850
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    Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors.
    Biochem Biophys Res Commun. 490:296-301, 2017. DOI:10.1016/j.bbrc.2017.06.039
  25. Gen Shiihashi, Daisuke Ito, Itaru Arai, Yuki Kobayashi, Kanehiro Hayashi, Shintaro Otsuka, Kazunori Nakajima, Michisuke Yuzaki, Shigeyoshi Itohara, Norihiro Suzuki
    Dendritic homeostasis disruption in a novel frontotemporal dementia mouse model expressing cytoplasmic fused in sarcoma.
    EBioMedicine 24:102-115, 2017. DOI:10.1016/j.ebiom.2017.09.005
  26. Okamoto M, Nakayama Y, Kakihana A, Yuki R, Yamaguchi N, Yamaguchi N
    Fyn Accelerates M Phase Progression by Promoting the Assembly of Mitotic Spindle Microtubules.
    J Cell Biochem. 117(4):610-623, 2016. DOI:10.1002/jcb.25373
  27. Honda T, Soeda S, Tsuda K, Yamaguchi C, Aoyama K, Morinaga T, Yuki R, Nakayama Y, Yamaguchi N, Yamaguchi N
    Protective role for lipid modifications of Src-family kinases against chromosome missegregation.
    Sci. Rep 6:38751, 2016. DOI:10.1038/srep38751
  28. Morii M, Kubota S, Honda T, Yuki R, Morinaga T, Kuga T, Tomonaga T, Yamaguchi N, Yamaguchi N
    Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530.
    J Biol Chem. 292(5):1648-1665, 2017. DOI:10.1074/jbc.M116.753202
  29. Morinaga T, Yanase S, Okamoto A, Yamaguchi N, Yamaguchi N
    Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells.
    Sci. Rep 7:493, 2017. DOI:10.1038/s41598-017-00538-5
  30. Sumitani M, Nishizawa D, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
    Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain.
    Pain Medicine 19:348-354, 2018. DOI:10.1093/pm/pnx102
  31. Katsushima K, Natsume A, Ohka F, Shinjo K, Hatanaka A, Ichimura N, Sato S, Takahashi S, Kimura H, Totoki Y, Shibata T, Naito M, Kim HJ, Miyata K, Kataoka K, Kondo Y.
    Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment.
    Nat Commun 7:13616-, 2016. DOI:10.1038/ncomms13616
  32. Horigane S*, Ageta-Ishihara N*(*共同筆頭著者), Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S, Bito H.
    Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKI pathway during neuronal polarization.
    Molecular brain 9(1):8, 2016. DOI:10.1186/s13041-016-0189-3
  33. Ide S, Takahashi T, Takamatsu Y, Uhl GR, Niki H, Sora I, Ikeda K.
    Distinct Roles of Opioid and Dopamine Systems in Lateral Hypothalamic Intracranial Self-Stimulation.
    Int J Neuropsychopharmacol. 20(5):403-409, 2017. DOI:10.1093/ijnp/pyw113
  34. Wu MK, Takemoto M, Taniguchi M, Takumi T, Okazaki T, Song W-J.
    Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1.
    American Journal of Physiology-Cell Physiology 311(1):C15-23, 2016. DOI:10.1152/ajpcell.00272.2015
  35. Tetsuhisa Otani, Yosuke Ogura, Kazuyo Misaki, Takuya Maeda, Akiyo Kimpara, Shigenobu Yonemura, Shigeo Hayashi
    IKKε inhibits PKC to promote Fascin-dependent actin bundling.
    Development 143:3806-3816, 2016. DOI:10.1242/dev.138495
  36. Yoshinori Asano, Tatsuya Kawase, Atsushi Okabe, Shuichi Tsutsumi, Hitoshi Ichikawa, Satoko Tatebe, Issay Kitabayashi, Fumio Tashiro, Hideo Namiki, Tadashi Kondo, Kentaro Semba, Hiroyuki Aburatani, Yoichi Taya, Hitoshi Nakagama and Rieko Ohki
    IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.
    Sci. Rep. 6:19174, 2016. DOI:10.1038/srep19174
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    Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.
    Rheumatology 55:1117-26, 2016. DOI:10.1093/rheumatology/kew005
  38. Nita A., Nishiyama M., Muto Y., Nakayama KI.
    FBXL12 regulates T cell differentiation in a cell-autonomous manner.
    Genes Cells 5:517-24, 2016. DOI:10.1111/gtc.12360
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    Identification of low-abundance proteins in serum via the isolation of HSP72 complexes.
    J Proteomics 136:214-21, 2016. DOI:10.1016/j.jprot.2016.01.008
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    Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.
    Nature Commun. 7:11289, 2016. DOI:10.1038/ncomms11289
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    To wake up cancer stem cells, or to let them sleep, that is the question.
    Cancer Sci. 107:875-81, 2016. DOI:10.1111/cas.12958
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    p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith–Wiedemann syndrome.
    J Pathol. 239:250-61, 2016. DOI:10.1002/path.4721
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    FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors.
    Cancer Sci. 107:1399-405, 2016. DOI:10.1111/cas.13026
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    CHD8 haploinsufficiency results in autistic-like phenotypes in mice.
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    Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling.
    Genes Cells 21:1095-112, 2016. DOI:10.1111/gtc.12406
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    The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.
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    GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
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    A large-scale targeted proteomics assay resource based on an in vitro human proteome.
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    FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem-progenitor cells.
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    生後発達期の小脳におけるシナプス刈り込みのメカニズム.
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    A Chimera Na+-Pump Rhodopsin as an Effective Optogenetic Silencer.
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