成果論文リスト
本支援による成果を含む論文として支援依頼者から報告があった論文を成果が得られた年度順に並べました。成果論文には「先端モデル動物支援」の課題番号「22H04922」を謝辞に入れることをお願いしていますが、課題番号の記載がない論文も含めています。
2020年度
- Shutoh F, Masuda T, Sasaki T, Takei Y.
Anomalous atrium associated with persistent left superior vena cava.
Anatomical Science International. -:2021, 1-5. DOI:10.1007/s12565-021-00604-z - Asano T, Teh DBL, Yawo H.
Application of Optogenetics for Muscle Cells and Stem Cells.
Adv Exp Med Biol. 1293:2021, 359-375. DOI:10.1007/978-981-15-8763-4_23 - M. Sumiyoshi, Y. Kotani, Y. Ikuta, K. Suzue, M. Ozawa, T. Katakai, T. Yamada, T. Abe, K. Bando, S. Koyasu, Y. Kanaho, T. Watanabe and S. Matsuda
Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation.
The Journal of Immunology 206:2021, 366-375. DOI:10.4049/jimmunol.2000971 - Ishida A, Igarashi K, Ruike Y, Ishiwata K, Naito K, Kono S, Deguchi H, Fujimoto M, Shiga A, Suzuki S, Yoshida T, Tanaka T, Tatsuno I, Yokote K, Koide H.
Association of urinary free cortisol with bone formation in patients with mild autonomous cortisol secretion.
Clin Endocrinol (Oxf). 94:2021, 544-550. DOI:10.1111/cen.14385 - Fujihara K, Sato T, Higeta K, Miyasaka Y, Mashimo T, Yanagawa Y.
Behavioral consequences of a combination of Gad1 haplodeficiency and adolescent exposure to NMDA receptor antagonist in Long-Evans rat.
Front Pharmacol. 12:2021, 646088. DOI:10.3389/fphar.2021.646088 - Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Maenaka K, Shimada T, Fukata M, Nishijo H, Takao K, Okabe S, Tabuchi K, Mishina M, Mori H, Fukai S.
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.
Nature Communications 12(1):2021, 1848. DOI:10.1038/s41467-021-22059-6 - Adhikara IM, Yagi K, Mayasari DS, Suzuki Y, Ikeda K, Ryanto GRT, Sasaki N, Rikitake Y, Nadanaka S, Kitagawa H, Miyata O, Igarashi M, Hirata K, Emoto N
Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
Arterioscler Thromb Vasc Biol 41(3):2021, 1076-1091. DOI:10.1161/ATVBAHA.120.315789 - Fumito Ishibashi, Tsutomu Fukuda, Shijiao Zha, Aya Hashirano, Shotaro Hirao, Masatomo Iwao
Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin.
Bioscience, Biotechnology, and Biochemistry 85:2021, 181-191. DOI:10.1093/bbb/zbaa028 - Sasaki T, Takei Y.
Constitutive increase of IL-17A in serum affects microglial activity in the hippocampal dentate gyrus.
Jap J Biol Psych. 32(2):2021, in press. - Shimizu T, Takahashi N, Huber VJ, Asawa Y, Ueda H, Yoshimori A, Muramatsu Y, Seimiya H, Kouji H, Nakamura H, Oguri H.
Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α.
Bioorg Med Chem. 30:2021, 115949. DOI:10.1016/j.bmc.2020.115949 - Doi H, Parajuli B, Horio T, Shigetomi E, Shinozaki Y, Noda T, Takahashi K, Hattori T, Koizumi S, Sawada K
Development of a label-free ATP image sensor for analyzing spatiotemporal patterns of ATP release from biological tissues.
Sensors and Actuators B: Chemical 335:2021, 129686. DOI:10.1016/j.snb.2021.129686 - Suzuki T, Ogita H, Sato A, Minamidate N, Hachiro K.
Differences between atherosclerotic and non-atherosclerotic patients in expression levels of inflammatory mediators in the adipose tissue around the coronary artery.
Int Heart J -:2021, in press. DOI:10.1536/ihj.20-585 - Katagiri T, Ushiki T, Nakajima-Takagi Y, Oshima M, Mikami T, Kawasaki A, Ishiguro H, Tanaka T, Sone H, Kitagawa H, Igarashi M, Iwama A, Masuko M
Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis.
Exp Hematol 96:2021, 52-62. DOI:10.1016/j.exphem.2021.02.003 - Tsutomu Fukuda, Seiya Okutani, Mayu Sumi, Kazuhito Miyagi, Gen Onodera, Masanari Kimura
Divergent Total Synthesis of Azalamellarins D and N.
Heterocycles 103:2021, in press. DOI:10.3987/COM-20-S(K)53 - Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K.
Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons.
Biomedicines 9 (1):2021, E49. DOI:10.3390/biomedicines9010049 - Ito, N., Riyadh, M., Ahmad, S., Hattori, S., Miyakawa, T. and Ohta, K. et al.
Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice.
Science Translational Medicine 13(587):2021, eaay7896. DOI:10.1126/scitranslmed.aay7896 - Sasaki T, Nagata R, Takahashi S, Takei Y
Effects of RORγt overexpression on the murine central nervous system.
Neuropsychopharmacology Reports -:2021, 1-9. DOI:10.1111/NPR2.12162 - Hikmawan Wahyu Sulistomo, Takayuki Nemoto, Yohko Kage, Hajime Fujii, Taku Uchida, Kogo Takamiya, Hideki Sumimoto, Hiroaki Kataoka, Haruhiko Bito, Ryu Takeya
Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.
Cerebral Cortex -:2021, in press. DOI:10.1093/cercor/bhaa355 - Fujihara K, Sato T, Miyasaka Y, Mashimo T, Yanagawa Y.
Genetic deletion of the 67-kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats.
FEBS Open Bio. -:2021, in press. DOI:10.1002/2211-5463.13065 - Sumitani M, Nishizawa D, Hozumi J, Ikeda K.
Genetic implications in quality palliative care and preventing opioid crisis in cancer-related pain management.
Journal of Neuroscience Research -:2021, in press. DOI:10.1002/jnr.24756 - Natsumeda M, Miyahara H, Yoshimura J, Okada M, Hirato J, Wataya T, Tateishi K, Rodriguez FJ, Suva ML, Taylor MD, Eberhart CG, Fujii Y, Kakita A
GLI3 is associated with neuronal differentiation in SHH-activated and WNT-activated medulloblastoma.
Journal of Neuropathology and Experimental Neurology 80(2):2021, 129-136. DOI:10.1093/jnen/nlaa141 - Miyata S, Kakizaki T, Fujihara K, Obinata H, Hirano T, Nakai J, Tanaka M, Itohara S, Watanabe M, Tanaka KF, Abe M, Sakimura K, Yanagawa Y.
Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice.
Mol Brain. 14:2021, 5. DOI:10.1186/s13041-020-00713-2 - Matsumoto K, Okamoto K, Okabe S, Fujii R, Ueda K, Ohashi K, Seimiya H.
G-quadruplex-forming nucleic acids interact with SF3B2 and suppress innate immune gene expression.
Genes Cells 26:2021, 65-82. DOI:10.1111/gtc.12824 - Dat NQ, Oikawa D, Yoishizato K, Tokunaga F, Pinzani M, Kawada M, et al.
His-Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
Hepatology. -:2021, in press. - Kumiko Naito,Sawako Suzuki,Chikako Ohwada,Jun-ichiro Ikeda,Tomoaki Tanaka,Koutaro Yokote.
ICAM1-Negative Intravascular Large B-Cell Lymphoma of the Pituitary Gland: A Case Report and Literature Review.
AACE Clinical Case Reports -:2021, in press. DOI:10.1016/j.aace.2021.01.011 - Aoki H, Abe C, Hara A, Miyazaki T, Morita H, Kunisada T.
Induced genetic ablation of Rest leads to the alteration of stimulus-induced response of the vagal nerve.
Genes Cells. 26(2):2021, 45-55. DOI:10.1111/gtc.12819 - Toshinori Matsuoka, Miwako Yamasaki, Manabu Abe, Yukiko Matsuda, Hiroyuki Morino, Hideshi Kawakami, Kenji Sakimura, Masahiko Watanabe, Kouichi Hashimoto
Kv11 (ether-à-go-go-related gene) voltage-dependent K+ channels promote resonance and oscillation of subthreshold membrane potentials.
Journal of Physiology (London) 599:2021, 547-569. DOI:10.1113/JP280342 - Nishiya N, Oku Y, Ishikawa C, Fukuda T, Dan S, Mashima T, Ushijima M, Matsuura M, Tomida A, Seimiya H, Yamori T, Iwao M, Uehara Y et al.
Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor.
Cancer Sci. -:2021, in press. DOI:10.1111/cas.14839 - T Shimizu, K Kimura, E Sugihara, S Yamaguchi‐Iwai, H Nobusue, O Sampetrean, Y Otsuki, Y Fukuchi, K Saitoh, K Kato, T Soga, A Muto, H Saya
MEK inhibition preferentially suppresses anchorage‐independent growth in osteosarcoma cells and decreases tumors in vivo.
Journal of Orthopaedic Research -:2021, in press. DOI:10.1002/jor.25023 - Asada-Utsugi M, Uemura K, Noda Y, 他8名, Takahashi R, Hattori S, Miyakawa T, Ageta-Ishihara N, Kobayashi K, Kinoshita M, Kinoshita A.
Mice with a cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial memory tasks.
Molecular Brain 14(1):2021, 23. DOI:10.1186/s13041-021-00738-1 - Tesshu Hori, Shohei Ikuta, Satoko Hattori, Keizo Takao, Tsuyoshi Miyakawa, Chieko Koike
Mice with mutations in Trpm1, a gene within the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior.
Molecular Brain 14(1):2021, 61. DOI:10.1186/s13041-021-00749-y - Mushiake H, Ohshiro T, Osawa SI, Hosaka R, Katayama N, Tanaka T, Yawo H, Osanai M.
Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits.
Adv Exp Med Biol. 1293:2021, 501-509. DOI:10.1007/978-981-15-8763-4_34 - Arima Y, Nakagawa Y, Takeo T, Ishida T, Yamada T, Hino S, Yamagata K, Nakamura T, Nakagata N, Tsujita K
Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.
Nature Metabolism 3:2021, 196-210. DOI:10.1038/s42255-021-00342-6 - Aki Takahashi, Hossein Aleyasin, Tetsuya Sasaki, Sonoko Ogawa, Bruce S. McEwen and Scott J. Russo et al
Neuromodulatory effect of interleukin 1 in the dorsal raphe nucleus on individual differences in aggression.
Molecular Psychiatry -:2021, in press. - Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Matsumoto H, Miyakawa T, Nakada K.
Neuronal degeneration and cognitive impairment can be prevented via the normalization of mitochondrial dynamics.
Pharmacol Res. 163:2021, 105246. DOI:10.1016/j.phrs.2020.105246 - Tatsuya Yamahira, Gen Onodera, Tsutomu Fukuda, Masanari Kimura
Ni-catalyzed direct carboxylation of propargylic alcohols with carbon dioxide.
Chemistry Letters -:2021, in press. DOI:10.1246/cl.210008 - Ying Luo, Bun Chan, Tsutomu Fukuda, Gen Onodera, Masanari Kimura
Nickel-Catalyzed Carboxylation of Conjugated Dienes with Carbon Dioxide and DIBAL-H for the Synthesis of β,γ-Unsaturated Carboxylic Acids.
Synlett -:2021, in press. DOI:10.1055/a-1336-8034 - Mori T, Kido A, Kawahara I, Nukaga S, Miyagawa Y, Goto K, Mori S, Kishi S, Fujii K, Fujiwara-Tani R, Kuniyasu H
Nutritional intervention for cancer sarcopenia.
Ann Muscloskeletal Med 5(1):2021, 001-004. DOI:10.17352/amm.000024 - Akira C Saito, Tomohito Higashi, Yugo Fukazawa, Tetsuhisa Otani, Masashi Tauchi, Atsuko Y Higashi, Mikio Furuse, Hideki Chiba
Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function.
Molecular biology of the cell -:2021, in press. DOI:10.1091/mbc.E20-07-0464 - Ando S, Fukamachi K, Yoshimoto E, Matsumoto H, Iinuma M and Suzui M.
Palmitoyl piperidinopiperidine, a novel derivative of 10-hydroxy-2-decenoic acid, as a potent and selective anticancer agent against human colon carcinoma cell lines.
Int J Oncol 58:2021, 251-265. DOI:10.3892/ijo.2020.5160 - Okada M, Kawagoe Y, Sato Y, Nozumi M, Ishikawa Y, Tamada A, Yamazaki H, Sekino Y, Kanemura Y, Shinmyo Y, Kawasaki H, Kaneko N, Sawamoto K, Fujii Y, Igarashi M
Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates.
Mol Brain 14(1):2021, 66. DOI:10.1186/s13041-021-00755-0 - Hayashi T
Post-translational palmitoylation of ionotropic glutamate receptors in excitatory synaptic functions.
British Journal of Pharmacology 178:2021, 784-797. DOI:10.1111/bph.15050 - Shinozaki Y, Koizumi S
Potential role of astrocytes and Muller cells in the pathogenesis of glaucoma.
Journal of Pharmacological Sciences 145:2021, 262-267. DOI:10.1016/j.jphs.2020.12.009 - H. Igata, Y. Ikegaya, T. Sasaki
Prioritized experience replays on a hippocampal predictive map for learning.
Proceedings of the National Academy of Sciences of the United States of America 118:2021, e2011266118. DOI:10.1073/pnas.2011266118 - Kakizaki T, Ohshiro T, Itakura M, Konno K, Watanabe M, Mushiake H, Yanagawa Y.
Rats deficient in the GAD65 isoform exhibit epilepsy and premature lethality.
FASEB J. 35(2):2021, e21224. DOI:10.1096/fj.202001935R - Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, Sugita K, Aihara M, Koizumi S.
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
JCI Insight -:2021, in press. DOI:10.1172/jci.insight.135391 - Johmura Y, Nakanishi M, et al
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.
Science 371(6526):2021, 265-270. DOI:10.1126/science.abb5916 - K.Hikita, Y.Yamakage, H.Okunaga, Y.Motoyama, H.Matsuyama, K.Matsuoka, T.Murata, T.Nakayoshi, A.Oda, K.Kato, H.Tanaka, N.Asao, S.Dan and N.Kaneda
(S)-erypoegin K, an isoflavone isolated from Erythrina poeppigiana, is a novel inhibitor of topoisomerase IIα: Induction of G2 phase arrest in human gastric cancer cells .
Bioorg. Med. Chem. 30:2021, 115904. DOI:10.1016/j.bmc.2020.115904 - Rahman NIA, Sato A, Tsevelnorov K, Shimizu A, Komeno M, Ahmat Amin MKB, Molla MR, Soh JEC, Nguyen LKC, Wada A, Kawauchi A, Ogita H.
Stomatin-mediated inhibition of the Akt signaling axis suppresses tumor growth.
Cancer Res -:2021, in press. DOI:10.1158/0008-5472.CAN-20-2331 - Tsutomu Fukuda, Fumito Ishibashi, Yusuke Oku, Naoyuki Nishiya, Yoshimasa Uehara, Masatomo Iwao
Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant.
Bioorganic & Medicinal Chemistry 34:2021, 116039. DOI:10.1016/j.bmc.2021.116039 - Taguchi K, Yamamoto M
The KEAP1-NRF2 system as a molecular target of cancer treatment.
Cancers 13:2021, 46. DOI:10.3390/cancers13010046 - Yamamura R, Ooshio T & Sonoshita M.
Tiny Drosophila makes giant strides in cancer research.
Cancer Sci 112:2021, 505-514. DOI:10.1111/cas.14747 - Yusuke Araki, Yusuke Hanaki, Masaki Kita, Koutaro Hayakawa, Kazuhiro Irie, Yoshihiko Nokura, Atsuo Nakazaki, and Toshio Nishikawa
Total Synthesis and Biological Evaluation of Oscillatoxin D, E, and F.
Bioscience, Biotechnology, and Biochemistry -:2021, in press. DOI:10.1093/bbb/zbab042 - Parajuli B, Saito H, Shinozaki Y, Shigetomi E, Miwa H, Yoneda S, Tanimura M, Omachi S, Asaki T, Takahashi K, Fujita M, Nakashima K, Koizumi S
Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.
GLIA -:2021, in press. - Chikuma S, Yamanaka S, Nakagawa S, Ueda MT, Hayabuchi H, Tokifuji Y, Kanayama M, Okamura T, Arase H, Yoshimura A
TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus.
The Journal of Immunology -:2021, in press. DOI:10.4049/jimmunol.2001003 - Miyajima K, Kawamoto C, Hara S, Mori-Kojima M, Ohye T, Sumi-Ichinose C, Saito N, Sasaoka T, Metzger D, Ichinose H
Tyrosine hydroxylase conditional knockout mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways.
Journal of Biological Chemistry -:2021, 100544. DOI:10.1016/j.jbc.2021.100544 - Huizi Keiko Li, Yukie Morokoshi, Satoshi Kodaira, Tamon Kusumoto, Katsuyuki Minegishi, Hiroaki Kanda, Kotaro Nagatsu, and Sumitaka Hasegawa
Utility of 211At-trastuzumab for the Treatment of Metastatic Gastric Cancer in the Liver: Evaluation of a Preclinical α-Radioimmunotherapy Approach in a Clinically-relevant Mouse Model.
Journal of Nuclear Medicine -:2021, in press. DOI:10.2967/jnumed.120.249300 - 田口恵子、山本雅之
環境応答・適応の分子機構.
日本体質医学学会誌 83:2021, in press. - Yuichiro Koga, Daisuke Tsuchimoto, Yoshinori Hayashi, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Hiroshi Nakanishi, Shinya Toyokuni, Yusaku Nakabeppu
Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy.
JCI Insight 5(22):2020, e140229. DOI:10.1172/jci.insight.140229 - Ichikawa J, Ando T, Kawasaki T, Sasaki T, Shirai T, Tsukiji N, Kimura Y, Aoki K, Hayakawa K, Suzuki-Inoue K, Saitoh M, Haro H.
Role of Platelet C-Type Lectin-Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma.
J Bone Miner Res 35(9):2020, 1738-1750. . DOI:10.1002/jbmr.4045 - Kataura T, Tashiro E, Nishikawa S, Onodera M, Shin-ya K, et al Sasazawa Y, Hattori N, Saiki S, and Imoto M
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Autophagy -:2020, in press. DOI:10.1080/15548627.2020.1794590 - M. Endoh, M. Baba, T. Endoh, A. Hirayama, A. Nakamura-Ishizu, T. Umemoto, M. Hashimoto, K. Nagashima, T. Soga, M. Lang, L.S. Schmidt, W.M. Linehan, T. Suda
A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity.
Cell Reports 30:2020, 1823 - 1834. DOI:10.1016/j.celrep.2020.01.042 - Koi H, Takahashi N, Fuchi Y, Umeno T, Muramatsu Y, Seimiya H, Karasawa S, Oguri H.
A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities.
Org Biomol Chem. 18:2020, 5339-5343. DOI:10.1039/d0ob00919a - Masumichi Saito, Hiroo Hasegawa, Shunsuke Yamauchi, et al.
A high‑throughput detection method for the clonality of Human T‑cell leukemia virus type‑1‑infected cells in vivo.
International Journal of Hematology 112(3):2020, 300-306. DOI:10.1007/s12185-020-02935-5 - Takahashi H, Yamanaka S, Kuwada S, Higaki K, Kido K, Sato Y, Fukai S, Tokunaga F, Sawasaki T.
A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors.
Biomedicines 8:2020, 152. DOI:10.3390/biomedicines8060152 - Eura N, Matsui TK, ..Kuniyasu H, Nagamori S, Muotri AR, Shin JW, Sugie K, Mori E
A human neurodevelopmental disease model using human brainstem organoids - Brainstem organoids from human pluripotent stem cells.
Front Neurosci 14:2020, 538. DOI:10.3389/fnins.2020.00538 - Masanori Kawabata, Shogo Soma, Akiko Saiki-Ishikawa, Satoshi Nonomura, Junichi Yoshida, Alain A Ríos, Yutaka Sakai, Yoshikazu Isomura
A spike analysis method for characterizing neurons based on phase locking and scaling to the interval between two behavioral events.
Journal of Neurophysiology 124:2020, 1923-1941. DOI:10.1152/jn.00200.2020 - Tsuboyama K., Osaki T., Matsuura-Suzuki E., Kozuka-Hata H., Okada Y., Oyama M., Ikeuchi Y., Iwasaki S., and Tomari Y.
A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation.
PLoS Biol. 18(3):2020, e3000632. DOI:10.1371/journal.pbio.3000632 - Kobayashi K, Endoh F, Ohmori I, Akiyama T.
Action of antiepileptic drugs on neurons.
Brain Dev. 42(1):2020, 2-5. DOI:10.1016/j.braindev.2019.07.006 - Kawakami R, Mashima T, Kawata N, Kumagai K, Migita T, Sano T, Mizunuma N, Yamaguchi K, Seimiya H.
ALDH1A3-mTOR axis as a therapeutic target for anticancer drug-tolerant persister cells in gastric cancer.
Cancer Sci. 111:2020, 962-973. DOI:10.1111/cas.14316 - Gotoh N, Saito Y, Hata S, Saito H, Ojima D, Murayama C, Shigeta M, Abe T, Konno D, Matsuzaki F, Suzuki T, Yamamoto T
Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α-deficient mice.
Journal of Biological Chemistry 295:2020, 9650-9662. DOI:10.1074/jbc.RA119.012386 - Mori S, Kishi S, Honoki K, Fujiwara-Tani R, Moriguchi T, Sasaki T, Fujii K, Tsukamoto S, Fujii H, Kido A, Tanaka Y, Luo Y, Kuniyasu H
Anti-stem cell property of pterostilbene in gastrointestinal cancer cells.
Int J Mol Sci 21:2020, 9347. DOI:10.3390/ijms21249347 - Tsunematsu T, Arakaki R, Kawai H, Ruppert J, Tsuneyama K, Ishimaru N, Earnshaw WC, Pagano M, Kudo Y.
APC/C-Cdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit.
Journal of Cell Science 133(18):2020, jcs251314. DOI:10.1242/jcs.251314 - Tetsuro Kawazoe, Hiroshi Saeki, Eiji Oki, Yoshinao Oda, Yoshihiko Maehara, Masaki Mori, Koji Taniguchi
Autocrine Leukemia Inhibitory Factor Promotes Esophageal Squamous Cell Carcinoma Progression via Src Family Kinase-Dependent Yes-Associated Protein Activation.
Molecular Cancer Research 18:2020, 1876-1888. DOI:10.1158/1541-7786.MCR-20-0186 - Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Murakami M, Tanaka T, Goda W, Hashimoto T, Miyakawa T, Iwatsubo T, Hata J, Niikura T, Yasui M et al.
Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model.
Acta Neuropathol. Commun. 8:2020, 67. DOI:10.1186/s40478-020-00936-3 - Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Hirashima M, Suzuki Y, Furuya M, Baba M, Kubota Y
Blood and lymphatic systems are segregated by the FLCN tumor suppressor.
Nature Communications volume 11:2020, 6314. DOI:10.1038/s41467-020-20156-6 - Kariba Y, Yoshizawa T, Sato Y, Tsuyama T, Araki E, Yamagata K
Brown adipocyte-derived miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes.
Biochem Biophys Res Commun 530:2020, 500-507. DOI:10.1016/j.bbrc.2020.05.090 - Yamamura S, Izumiya Y, Araki S, Nakagata N, Bober E, Braun T, Sakamoto K, Kaikita K, Morimoto T, Yamagata K, Tsujita K
Cardiomyocyte Sirt (Sirt7)7 ameliorates stress-induced cardiac hypertrophy by interacting with and deacetylating GATA4.
Hypertension 75:2020, 98-108. DOI:10.1161/HYPERTENSIONAHA.119.13357 - Oikawa D, Hatanaka N, Suzuki T, Tokunaga F.
Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-κB Activation Pathway.
Front Immunol. 11:2020, 601926. DOI:10.3389/fimmu.2020.601926 - Saito M, Kagawa N, Okumura K, Munakata H, Isogai E, Fukagawa T, Wakabayashi Y.
CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model.
Cancer Science. 111:2020, 2850-2860. DOI:10.1111/cas.14533 - Inada R, Miyamoto K, Tanaka N, Moriguchi K, Kadomatsu K, Takeuchi K, Igarashi M, Kusunoki S
Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type.
Glycobiology. -:2020, cwaa072. DOI:10.1093/glycob/cwaa072 - Yoshimi K, Oka Y, Miyasaka Y, Kotani Y, Yasumura M, Uno Y, Hattori K, Tanigawa A, Sato M, Oya M, Nakamura K, Matsushita N, Kobayashi K, Mashimo T
Combi-CRISPR: combination of NHEJ and HDR provides efficient and precise plasmid-based knock-ins in mice and rats.
Human Genetics 140(2):2020, 277-287. DOI:10.1007/s00439-020-02198-4 - Noriho Shinagawa, Kentaro Minami, Takayuki Ishida, Hiroshi Hijioka, Masatatsu Yamamoto, Kohichi Kawahara, Tatsuhiko Furukawa, Norifumi Nakamura
Combination of hydroxyurea and tranilast suppresses gemcitabine resistance induced by ribonucleotide reductase M1 in gemcitabine‐resistant cells.
Oral Sci Int -:2020, 1-9. DOI:10.1002/osi2.1096 - Nukaga S, Mori T, Miyagawa Y, Fujiwara-Tani R, Sasaki T, Fujii K, Mori S, Goto K, Kishi S, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H
Combined administration of medium-chain fatty chain and glucose improved cancer-derived cardiac atrophy in a mouse cachexia model.
Cancer Sci 111:2020, 4605-4615. DOI:10.1111/cas.14656 - Miyazaki T, Yamasaki M, Tanaka KF, Watanabe M.
Compartmentalized input-output organization of Lugaro cells in the cerebellar cortex.
Neuroscience 2020 May 26:S0306-4522(20):2020, 30322-5. DOI:10.1016/j.neuroscience.2020.05.026 - Suzuki Ta., .. Mito M., Iwasaki S., Ma D., Zhao X., Asano K., Lin H., Kirino Y., Sakaguchi Y., and Suzuki Ts.
Complete chemical structures of human mitochondrial tRNAs.
Nat Commun. 11(1):2020, 4269. DOI:10.1038/s41467-020-18068-6 - Fujihara K, Yamada K, Ichitani Y, Kakizaki T, Suto T, Watanabe M, Kajita Y, Ohshiro T, Mushiake H, Miyasaka Y, Mashimo T, Yasuda H, Yanagawa Y.
CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia.
Transl Psychiatry. 10:2020, 426. DOI:10.1038/s41398-020-01108-6 - Seimiya H.
Crossroads of telomere biology and anticancer drug discovery.
Cancer Sci. 111:2020, 3089-3099. DOI:10.1111/cas.14540 - Takujiro Homma, Yuji Takeda, Tomoyuki Nakano, Shinya Akatsuka, Daisuke Kinoshita, Toshihiro Kurahashi, Shinichi Saitoh, Ken-Ichi Yamada, Satoshi Miyata, Hironobu Asao, Kaoru Goto, Tetsu Watanabe, Masafumi Watanabe, Shinya Toyokuni, Junichi Fujii.
Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue.
Free Radical Biology & Medicine 162:2020, 255-265. DOI:10.1016/j.freeradbiomed.2020.10.023 - Masai H, Kanoh Y, Kakusho N, Fukatsu R.
Detection of cellular G-quadruplex by using a loop structure as a structural determinant.
Biochem Biophys Res Commun. 531:2020, 75-83. DOI:10.1016/j.bbrc.2020.05.191 - Ageta-Ishihara N and Kinoshita M
Developmental and postdevelopmental roles of septins in the brain.
Neurosci Res S0168-0102(20):2020, 30440-5. DOI:10.1016/j.neures.2020.08.006 - Fujiwara-Tani R, Sasaki T, Fujii K, Luo Y, Kishi S, Mori S, Matsushima-Otsuka S, Nishiguchi Y, Mori T, Nukaga S, Goto K, Kawahara I, Kondoh M, Sho M, Kuniyasu H
Diabetes mellitus is associated with liver metastasis of colorectal cancer.
Oncotarget 11:2020, 2982-2994. DOI:10.18632/oncotarget.27674 - KazuhiroSakamoto, NorihikoKawaguchi, HajimeMushiake
Differences in task-phase-dependent time-frequency patterns of local field potentials in the dorsal and ventral regions of the monkey lateral prefrontal cortex.
Neuroscience Research 156:2020, 41-49. DOI:10.1016/j.neures.2019.12.016 - Mukai S, Nakada S, Kamada H, Yaguchi R, Deyama S, Kaneda K
Differential sensitivity to detect prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice.
Neuropsychopharmacology Reports 40:2020, 297-301. DOI:10.1002/npr2.12124 - Gen Onodera, Hidenobu Kumagae, Daiki Nakamura, Takuto Hayasaki, Tsutomu Fukuda, Masanari Kimura
Direct benzylation of amines with benzylic alcohols catalyzed by palladium/phosphine-borane catalyst system.
Tetrahedron Letters 61:2020, 152537. DOI:10.1016/j.tetlet.2020.152537 - Horie M, Yoshioka N, Kusumi S, Sano H, Kurose M, Watanabe-Iida I, Hossain I, Chiken S, Abe M, Yamamura K, Sakimura K, Nambu A, Shibata M, Takebayashi H.
Disruption of dystonin in Schwann cells results in late-onset neuropathy and sensory ataxia.
GLIA 68:2020, 2330-2344. DOI:10.1002/glia.23843 - 36. Chen M, Asanuma M, Takahashi M, Shichino Y, Mito M, Fujiwara K, Saito H, Floor SN, Ingolia NT, Sodeoka M, Dodo K, Ito T, and Iwasaki S
Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A.
Cell Chem Biol. -:2020, in press. DOI:10.1016/j.chembiol.2020.11.008 - Kazuhiro Sakamoto, Naohiro Saito, Shun Yoshida and Hajime Mushiake
Dynamic Axis-Tuned Cells in the Monkey Lateral Prefrontal Cortex during a Path-Planning Task.
The Journal of Neuroscience 40:2020, 203 - 219. DOI:10.1523/JNEUROSCI.2526-18.2019 - Saito K., Pérez-de la Fuente R., Arimoto K., Young ah S., Aonuma H., Niiyama N and You Z.
Earwig fan designing: biomimetic and evolutionary biology applications.
Proceedings of the National Academy of Sciences U.S.A. 117(30):2020, 17622-17626. DOI:10.1073/pnas.2005769117 - Sato M., Chou S.-J.
Editorial: The Earliest-Born Cortical Neurons as Multi-Tasking Pioneers: Expanding Roles for Subplate Neurons in Cerebral Cortex Organization and Function.
Frontiers in Neuroanatomy 14:2020, 43. DOI:10.3389/fnana.2020.00043 - Sasaki T, Mori S, Kishi S, Fujiwara-Tani R, Ohmori H, Nishiguchi Y, Kawahara I, Nakashima C, Fujii K, Luo Y, Kuniyasu H
Effect of proton pump inhibitors on colorectal cancer.
Int J Mol Sci 21(11):2020, E3877. DOI:10.3390/ijms21113877 - Atsuko Gonda, Koji Takada, Ryo C. Yanagita, Shingo Dan, and Kazuhiro Irie*
Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities.
Bioscience, Biotechnology and Biochemistry 85(1):2020, 168-180. DOI:10.1093/bbb/zbaa024 - Saori Miwa, Ayako M. Watabe, Yohta Shimada, Takashi Higuchi, Hiroshi Kobayashi, Takahiro Fukuda, Fusao Kato, Hiroyuki Ida, Toya Ohashi
Efficient engraftment of genetically modified cells is necessary to ameliorate 1 central nervous system involvement of murine model of mucopolysaccharidosis type II by hematopoietic stem cell targeted gene therapy.
Molecular Genetics and Metabolism 130:2020, 262-273. DOI:10.1016/j.ymgme.2020.06.007 - Masami Ishido, Eiko Shimaya
Electromagnetic fields (EMF) facilitate cell migration and BrdU incorporation during an EMF-sensitive phase in a rat neurosphere assay in vitro.
Fund Toxicol Sci 7:2020, 253-257. DOI:10.2123/fts7.253 - Nishio M, et al.
Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.
Cancer Sci. 111:2020, 3576-3587. DOI:10.1111/cas.14581 - Shinji Hirotsune, Hiroshi Kiyonari, Mingyue Jin, Kanako Kumamoto, Kayo Yoshida, Miki Shinohara, Hitomi Watanabe, Anthony Wynshaw-Boris, Fumio Matsuzaki
Enhanced homologous recombination by the modulation of targeting vector ends.
Scientific reports 10:2020, 2518. DOI:10.1038/s41598-020-58893-9 - Fukabori, R, Iguchi, Y, .., Benton, R, Kobayashi, K
Enhanced retrieval of taste associative memory by chemogenetic activation of locus coeruleus norepinephrine neurons.
The Journal of Neuroscience 40:2020, 8367-8385. DOI:10.1523/jneurosci.1720-20.2020 - H. Nasser, P. Adhikary, A. Abdel-Daim, O. Noyori, J. Panaampon, R. Kariya, S. Okada, W. Ma, M. Baba, H. Takizawa, M. Yamane, H. Niwa, S. Suzu
Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages.
Cell death discovery 6:2020, 1-14. DOI:10.1038/s41420-020-00300-3 - Miyagawa Y, Nukaga S, Mori T, Fujiwara-Tani R, Fujii K, Mori S, Goto K, Kishi S, Sasaki T, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H
Evaluation of cancer-derived myocardial impairments using a mouse model.
Oncotarget 11:2020, 3712-3722. DOI:10.18632/oncotarget.27759 - Amodio P., Shigeno, S. Ostojić L.
Evolution of Intelligence in cephalopods.
eLS 77 - 84829 1:2020, 77. DOI:10.1002/9780470015902.a0029004 - Sasaki T, Komatsu Y, Yamamori T.
Expression patterns of SLIT/ROBO mRNAs reveal a characteristic feature in the entorhinal-hippocampal area of macaque monkeys.
BMC Res Notes 262(13):2020, 1-6. DOI:10.1186/s13104-020-05100-7 - Yoshida K, Ito MA, Sato N, Obayashi K, Yamamoto K, Koizumi S, Tanaka S, Furuta K, Matsuoka I
Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation. .
J Immunol 204:2020, 3077-3085. DOI:10.4049/jimmunol.1900954 - Y. Isono, M. Furuya, T. Kuwahara, D. Sano, K. Suzuki, R. Jikuya, T. Mitome, S. Otake, M. Baba, LS Schmidt, WM Linehan, T. Kodama, M. Yao, N. Oridate, H. Hasumi
FLCN alteration drives metabolic reprogramming towards nucleotide synthesis and cyst formation in salivary gland.
Biochemical and Biophysical Research Communications 522:2020, 931-938. DOI:10.1016/j.bbrc.2019.11.184 - Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
Fracture Risk Assessment Tool May Not Indicate Bone Fragility in Women With Type 2 Diabetes.
Am J Med Sci. 360:2020, 552-559. DOI:10.1016/j.amjms.2020.04.002 - Omori S, Wang TW, Johmura Y, Makoto Nakanishi, et al
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16 high Cells In Vivo.
Cell Metabolism 32:2020, 814-828. DOI:10.1016/j.cmet.2020.09.006 - Yingsong, Lin., Doki, Y., Ishii, Hideshi, Eguchi, H., Mori, Masaki, Matsuo, K.
Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.
Nature Commun. 11(1):2020, 3175. DOI:10.1038/s41467-020-16711-w - Han P., Shichino Y., Schneider-Poetsch T., Mito M., Hashimoto S., Udagawa T., Kohno K., Yoshida M., Mishima Y., Inada T., and Iwasaki S.
Genome-wide survey of ribosome collision.
Cell Rep. 31(5):2020, 107610. DOI:10.1016/j.celrep.2020.107610 - Hata, M., Kinoshita, H., Hayakawa, Y., (他12名), Kon, S., Tomita, H., Wang, T.C., Koike, K.
GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia.
Gastroenterology 158:2020, 1650-1666. DOI:10.1053/j.gastro.2020.01.046 - Alavi S, Ghadiri H, Dabirmanesh B, Moriyama K, Khajeh K, Masai H.
G-quadruplex binding protein Rif1, a key regulator of replication timing.
J Biochem. -:2020, in press. DOI:10.1093/jb/mvaa128 - Masai H, Tanaka T.
G-quadruplex DNA and RNA: Their roles in regulation of DNA replication and other biological functions.
Biochem Biophys Res Commun. 531:2020, 25-38. DOI:10.1016/j.bbrc.2020.05.132 - Asai, A., Konno M., Kawamoto K., Isotani, A., Mori, M., Eguchi H., Doki, Y., Arai, T., Ishii, H.
Hereditary pancreatitis model by blastocyst complementation in mouse.
Oncotarget 11(22):2020, 2061-2073. DOI:10.18632/oncotarget.27595 - Nakayama J, Saito R, Hayashi Y, Kitada N, Tamaki S, Han Y, Semba K and Maki SA
High Sensitivity In Vivo Imaging of Cancer Metastasis Using a Near-Infrared Luciferin Analogue seMpai.
International Journal of Molecular Sciences 21:2020, 1-8. DOI:10.3390/ijms21217896 - Kanako Maehata, Kimiko Shimizu*, Tomoko Ikeno, Qiuyi Wang, Ayaka Sakurai, Zefeng Wei, Yue Pan, Toshifumi Takao and Yoshitaka Fukada
Hippocampal 7α-hydroxylated neurosteroids are raised by training and bolster remote spatial memory with increase of the spine densities.
iScience 23(10):2020, 101559. DOI:10.1016/j.isci.2020.101559 - Sato Y, Rahman MM, Haneda M, Tsuyama T, Mizumoto T, Yoshizawa T, Kitamura T, Gonzalez FJ, Yamamura K, Yamagata K
HNF1a controls glucagon secretion in pancreatic a-cells through modulation of SGLT1.
BBA – Mol Basis Dis 1866:2020, 165898. DOI:10.1016/j.bbadis.2020.165898 - Htun, Y. Nakamura, S. Kusaka, T
Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.
Pediatric Research -:2020, in press. DOI:10.1038/s41390-020-0998-z - Iwata S, Sasaki T, Takei Y.
Imaging of activity-dependent local translation in dendrite using photoconvertible protein.
Medical Science Digest 45(6)::2020, 64-65. - Morita Y, Senokuchi T, Yamada S, Wada T, Furusho T, Matsumura T, Ishii N, Murakami-Nishida S, Nisida S, Motoshima H, Komohara Y, Yamagata K, Araki E
Impact of tissue macrophage proliferation on peripheral and systemic insulin resistance in obese mice with diabetes.
BMJ Open Diabetes Research & Care 8:2020, e001578. DOI:10.1136/bmjdrc-2020-001578 - Arima-Yoshida F, Raveau M, Shimohata A, Amano K, Fukushima A, Watanave M, Kobayashi S, Hattori S, Usui M, Sago H, Mataga N, Miyakawa T, Yamakawa K, Manabe T.
Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABA B receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice.
Scientific Report 10:2020, 14187. DOI:10.1038/s41598-020-71085-9 - Nakazawa K. Shichino Y., Iwasaki S., and Shiina N.
Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation.
J Biol Chem. 295(44):2020, 15029-15044. DOI:10.1074/jbc.RA120.012715 - Yamato, S. H. Nakamura, S. Htun, Y. Nakamura, M. Jinnai, W. Nakao, Y. Mitsuie, T. Koyano, K... Iwase, T. Kondo, S. I. Yasuda, S. Ueno, M. Miki, T. Kusaka, T.
Intravenous Edaravone plus Therapeutic Hypothermia Offers Limited Neuroprotection in the Hypoxic-Ischaemic Newborn Piglet.
Neonatology -:2020, 1-8. DOI:10.1159/000511085 - Tetsuya Sasaki, Saki Tome, Yosuke Takei
Intraventricular IL-17A administration activates microglia and alters their localization in the mouse embryo cerebral cortex.
Molecular Brain 13(1):2020, 93. DOI:10.1186/s13041-020-00635-z - Takeuchi Y., Tatsuta S., Kito A., Fujikawa J., Itoh S., Itoh Y., Akiyama S., Yamashiro T., Wakisaka S., Abe M.
Kruppel-Like Factor 4 upregulates Matrix Metalloproteinase 13 expression in chondrocytes via mRNA stabilization.
Cell Tissue Research 382(2):2020, 307-319. DOI:10.1007/s00441-020-03228-3 - Fracassi A, Masai H, Yamakoshi Y.
LDL-mimetic lipid nanoparticles prepared by surface KAT ligation for in vivo MRI of atherosclerosis.
Chem Sci 44:2020, 11998-12008. DOI:10.1039/D0SC04106H - Shogo Sasaki, Yue Ma, Takumi Ishizuka, Hong-Liang Bao, Takatsugu Hirokawa, Yan Xu, Masayuki Tera, Kazuo Nagasawa
Linear Consecutive Hexaoxazoles as G4 Ligands Inducing Chair-type Anti-parallel Topology of Telomeric G-Quadruplex.
RSC Adv. 10:2020, 43319-43323. DOI:10.1039/D0RA09413G - Oikawa D, Sato Y, Ito H, Tokunaga F.
Linear ubiquitin code: Its writer, erasers, decoders, inhibitors, and implications in disorders.
Int J Mol Sci. 21(9):2020, E3381. DOI:10.3390/ijms21093381 - Sasaki T, Takei Y.
Localization Mechanism of Myosin Id, an ASD Risk Gene Product in Dendritic Spines.
Jap J Biol Psych. 31(2):2020, 93-97. DOI:10.11249/jsbpjjpp.31.2_93 - T. Adachi, K. Yasuda, T. Muto, S. Serada, T. Yoshimoto, K. J. Ishii, E. Kuroda, K. Araki, M. Ohmuraya, T. Naka and K. Nakanishi
Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2.
International Immunology 32(10):2020, 637-652. DOI:10.1093/intimm/dxaa031 - Nakashima C, Kirita T, Yamamoto K, Mori S, Luo Y, Sasaki T, Fujii K, Ohmori H, Kawahara I, Mori T, Goto K, Kishi S, Fujiwara-Tani R, Kuniyasu H
Malic enzyme 1 is associated with tumor budding in oral squamous cell carcinomas.
Int J Mol Sci 21(19):2020, 7149. DOI:10.3390/ijms21197149 - Sakayori, N, Katakura, M, Hamazaki, K, Higuchi, O, Fujii, K, Fukabori, R, Iguchi, Y, Setogawa, S, Takao, K, Miyazawa, T, Arita, M, Kobayashi, K
Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice.
Communications Biology 3(1):2020, 473. DOI:10.1038/s42003-020-01209-4 - Nobuyuki Sakayori, Kazuki Fujii, Keizo Takao, Kazuto Kobayashi, et al.
Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring's overeating in mice.
Communications Biology 3:2020, 473. DOI:10.1038/s42003-020-01209-4 - Takemoto K., Tani N., Takada Y., Fujimura S., Tanno N., Yamane M., Okamura K., Sugimoto M., Araki K., Ishiguro K.
Meiosis-specific C19orf57/4930432K21Rik/BRME1 modulates localization of RAD51 and DMC1 to DSBs in mouse meiotic recombination.
Cell Reports 31:2020, 107686. DOI:10.1016/j.celrep.2020.107686 - Fujiwara Y., Horisawa-Takada Y., Inoue E., Tani N., Shibuya H., Fujimura S., Kariyazono R., Sakata T., Ohta K., Araki K., Okada Y., Ishiguro K.
Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase.
PLOS Genetics 16(9):2020, e1009048. DOI:10.1371/journal.pgen.1009048 - Doki C, Nishida K, Saito S, Shiga M, Ogara H, Kuramoto A, Kuragano M, Nozumi M, Igarashi M, Nakagawa H, Kotani S, Tokuraku K.
Microtubule elongation along actin filaments induced by microtubule-associated protein 4 contributes to the formation of cellular protrusions.
J Biochem 168(3):2020, 295-303. DOI:10.1093/jb/mvaa046 - Oikawa D, Sato Y, 13名略, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
Commun Biol. 3:2020, 163. DOI:10.1038/s42003-020-0882-8 - Hitoshi Suzuki, Gohta Kinoshita, Takeru Tsunoi, Mitsuki Noju, Kimi Araki
Mouse hair significantly lightened through replacement of the cysteine residue in the N-terminal domain of Mc1r using the CRISPR/Cas9 system.
Journal of Heredity 111(7):2020, 640-645. DOI:10.1093/jhered/esaa054 - Noritaka Yamaguchi
Multiple Roles of Vestigial-Like Family Members in Tumor Development.
Frontiers in Oncology 10:2020, 1266. DOI:10.3389/fonc.2020.01266 - Igarashi M, Honda A, Kawasaki A, Nozumi M.
Neuronal Signaling Involved in Neuronal Polarization and Growth: Lipid Rafts and Phosphorylation.
Front Mol Neurosci 13:2020, 150. DOI:10.3389/fnmol.2020.00150 - Shinohara S, Arakaki S, Amano T, Minami M, Kaneda K
Noradrenaline enhances the excitatory effects of dopamine on medial prefrontal cortex pyramidal neurons in rats.
Neuropsychopharmacology Reports 40:2020, 348-354. DOI:10.1002/npr2.12135 - Naniwa K., Sugimoto Y., Osuka K. and Aonuma H.
Novel method for analyzing flexible locomotion patterns of animals by using polar histogram.
Journal of Robotics and Mechatronics 32:2020, 812-821. DOI:10.20965/jrm.2020.p0812 - Ikeda H, Muroi M, Kondoh Y, Ishikawa S, Kakeya H, Osada H, Imoto M
Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-catenin Mutant Tumor Cells.
ACS Chem. Biol 15:2020, 2195-2204. DOI:10.1021/acschembio.0c00381 - Saeki N., Eguchi Y., Kintaka R., Makanae K., Shichino Y., Iwasaki S., Kanno M., Kimura N., and Moriya H.
N-terminal deletion of Swi3 created by the deletion of a dubious ORF YJL175W mitigates protein burden effect in S. cerevisiae.
Sci Rep. 10(1):2020, 9500. DOI:10.1038/s41598-020-66307-z - Yu Chen and Rieko Ohki.
p53-PHLDA3-Akt Network: The Key Regulators of Neuroendocrine Tumorigenesis.
Int. J. Mol. Sci. 21(11):2020, 4098. DOI:10.3390/ijms21114098 - Okumura K, Saito M, Yoshizawa Y, Ito Y, Isogai E, Araki K, Wakabayashi Y.
Pak1 maintains epidermal stem cells by regulating Langerhans cells and is required for skin carcinogenesis.
Oncogene. 39(24):2020, 4756-4769. DOI:10.1038/s41388-020-1323-3 - Harada, T., Sada, R., Osugi, Y., Matsumoto, S., Matsuda, T., Hayashi-Nishino, M., Nagai, T., Harada, A., Kikuchi, A.
Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER&[minus]mitochondria contact sites.
J Cell Sci. 133(21):2020, jcs249045. DOI:10.1242/jcs.249045 - Shinozaki Y, Koizumi S
Pathogenic roles of retinal glia in glaucoma.
Nihon Yakurigaku Zasshi 155:2020, 87-92. DOI:10.1254/fpj.19120 - Arai H, Takahashi R, Sakamoto Y, Kitano T, Mashita O, Hara S, Yoshikawa S, Kawasaki K, Ichinose H.
Peripheral tetrahydrobiopterin is involved in the pathogenesis of mechanical hypersensitivity in a rodent postsurgical pain model.
Pain 161:2020, 2520-2531. DOI:10.1097/j.pain.0000000000001946 - Kohno S*, Linn P*, Nagatani N, Watanabe Y, Kumar S, Soga T and Takahashi C. * equal contribution
Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion.
Oncogene 39:2020, 5690-5707. DOI:10.1038/s41388-020-1381-6 - Igarashi M, Kawasaki A, Ishikawa Y, Honda A, Okada M, Okuda S
Phosphoproteomic and bioinformatic methods for analyzing signaling in vertebrate axon growth and regeneration.
J Neurosci Methods 339:2020, 108723. DOI:10.1016/j.jneumeth.2020.108723 - Tanno N., Kuninaka S., Fujimura S., Takemoto K., Okamura K., Takeda N., Araki K., Araki M., Saya H. and Ishiguro K.
Phosphorylation of the Anaphase Promoting Complex activator FZR1/ CDH1 is required for Meiosis II entry in mouse male germ cell.
Scientific Reports 10:2020, 10094. DOI:10.1038/s41598-020-67116-0 - Christian Hartmann, Ysabel Alessa Schwietzer, Tetsuhisa Otani, Mikio Furuse, Klaus Ebnet
Physiological functions of junctional adhesion molecules (JAMs) in tight junctions.
Biochimica et biophysica acta. Biomembranes 1862(9):2020, 183299-183299. DOI:10.1016/j.bbamem.2020.183299 - Onishi R, Sato K, Murano K, Negishi L, Siomi H, Siomi MC.
Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells.
Sci. Adv. 6:2020, eaaz7420. DOI:10.1126/sciadv.aaz7420 - Ohi K, Nishizawa D, Muto Y, Sugiyama S, Hasegawa J, Soda M, Kitaichi K, Hashimoto R, Shioiri T, Ikeda K
Polygenic Risk Scores for Late Smoking Initiation Associated with the Risk of Schizophrenia.
NPJ Schizophr 6(1):2020, 36. DOI:10.1038/s41537-020-00126-z - Kuroiwa Y, Nakayama J, Adachi C, Inoue T, Watanabe S and Semba K
Proliferative Classification of intracranially injected HER2-positive Breast Cancer Cell Lines.
Cancers 12:2020, 1-18. DOI:10.3390/cancers12071811 - Mito M, Mishima Y, and Iwasaki S
Protocol for disome profiling to survey ribosome collision in humans and zebrafish.
STAR Protoc. 1(3):2020, 100168 . DOI:10.1016/j.xpro.2020.100168 - Kuniyasu H
Pterostilbene in Gastrointestinal Cancer Cells.
MDPI Scholarly Community Encyclopedia-Topic Review 2020:2020, 1-3. - Taishi Kobayashi, Takuro Murakami, Yuu Hirose, and Toshihiko Eki
Purification and characterization of double-stranded nucleic acid-dependent ATPase activities of tagged Dicer-related helicase 1 and its short isoform in Caenorhabditis elegans.
Genes 11:2020, 734. DOI:10.3390/genes11070734 - Matsuki Y, Matsuo Y, Nakano Y, Iwasaki S, Yoko H, Udagawa T, Li S, Saeki Y, Yoshihisa T, Tanaka K, Ingolia NT, and Inada T.
Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome.
Sci Rep 10(1):2020, 19669. DOI:10.1038/s41598-020-76239-3 - Kunishige H, Migita K, Matsumoto S, Wakatsuki K, Nakade H, Miyao S, Kuniyasu H, Sho M
Ring box protein-1 is associated with a poor prognosis and tumor progression in esophageal cancer.
Oncol Lett 20:2020, 2919-2927. DOI:10.3892/ol.2020.11840 - Chu J, Deyama S, Li X, Motono M, Otoda A, Saito A, Esaki H,Nishitani N, Kaneda K
Role of 5-HT1A receptor-mediated serotonergic transmission in the medial prefrontal cortex in acute restraint stress-induced augmentation of rewarding memory of cocaine in mice.
Neuroscience Letters 743:2020, 135555. DOI:10.1016/j.neulet.2020.135555 - Fujiwara-Tani R, Fujii K, Mori S, Kishi S, Sasaki T, Ohmori H, Nakashima C, Kawahara I, NishiguchiY, Mori T, Sho M, Kondoh M, Luo Y, Kuniyasu H
Role of Clostridium perfringens enterotoxin on YAP activation in colonic sessile serrated adenoma/polyp with dysplasia.
Int J Mol Sci 21(11):2020, E3840. DOI:10.3390/ijms21113840 - Owari T, Takamitsu Sasaki T, Fujii K, Fujiwara-Tani R, Kishi S, Mori S, Mori T, Goto K, Kawahara I, ...Luo Y, Tanaka N, Kondoh M, Fujimoto K, Kuniyasu H
Role of nuclear claudin-4 in renal cell carcinoma.
Int J Mol Sci 21:2020, 8340. DOI:10.3390/ijms21218340 - Fukai S, Yoshida T.
Roles of type-IIa receptor protein tyrosine phosphatases as synaptic organizers.
FEBS Journal -:2020, in press. DOI:10.1111/febs.15666 - T Nakayama, K Okimura, J Shen, YJ Guh, 中略, K Nakayama, N Shiina, N Yamamoto, AS Loudon, T Nishiwaki-Ohkawa, A Shinomiya, T Nabeshima, Y Nakane and T Yoshimura
Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior.
Proc. Natl. Acad. Sci. U.S.A. 117:2020, 9594 - 9603. DOI:10.1073/pnas.2000278117 - Aonuma H.
Serotonergic control in initiating defensive responses to unexpected tactile stimuli in the trap-jaw ant Odontomachus kuroiwae.
Journal of Experimental Biology 223(Pt 19):2020, jeb228874. DOI:10.1242/jeb.228874 - Yokoi S, Naruse K, Kamei Y, Ansai S, Kinoshita M, Mito M, Iwasaki S., Inoue S, Okuyama T, Nakagawa S, Young LJ, and Takeuchi H.
Sexually dimorphic role of oxytocin in medaka mate choice.
Proc Natl Acad Sci USA. 117(9):2020, 4802-4808. DOI:10.1073/pnas.1921446117 - Tomita I, Kume S, Sugahara S, .., Ogita H, Araki SI, Maegawa H.
SGLT2 inhibition mediates protection from diabetic kidney disease by promoting ketone body-induced mTORC1 inhibition.
Cell Metab. 32:2020, 404-419. DOI:10.1016/j.cmet.2020.06.020 - Nishida KM, Sakakibara K, Sumiyoshi T, Yamazaki H, Mannen T, Kawamura T, Kodama T, Siomi MC.
Siwi levels reversibly regulate secondary piRISC biogenesis by affecting Ago3 body morphology in Bombyx mori.
EMBO J. 39:2020, e105130. DOI:10.15252/embj.2020105130 - Uchigashima M, Konno K, Demchak E, Cheung A, Watanabe T, Keener D G, Abe M, Sakimura K, Sasaoka T, Uemura T, Imamura Karasawa Y, Watanabe M, Futai K.
Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus.
Elife 9:2020, e59545. DOI:10.7554/eLife.59545 - Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H.
Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells.
Biomed Pharmacother. 128:2020, 110330-110340. DOI:10.1016/j.biopha.2020.110330 - Suzuki S, Minamidate T, Shiga A, Ruike Y, Ishiwata K, Naito K, Ishida A, Deguchi H, Fujimoto M, Koide H, Tatsuno I, Ikeda JI, Yamazaki Y, Sasano H, Yokote K.
Steroid metabolites for diagnosing and predicting clinicopathological features in cortisol-producing adrenocortical carcinoma.
BMC Endocr Disord. 20:2020, in press. DOI:10.1186/s12902-020-00652-y - Moe Matsushita, Takanori Nakamura, Hisashi Moriizumi, Hiroaki Miki, Mutsuhiro Takekawa
Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress.
Science Advances 6(26):2020, eaay9778. DOI:10.1126/sciadv.aay9778 - Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, and Noriyuki Sugo
Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons.
The Journal of Neuroscience 40(47):2020, 9012-9027. DOI:10.1523/JNEUROSCI.0319-20.2020 - Lin, Z, Nishikawa, H, Iguchi, Y, Iwanami, A, Kikuchi, M, Toda, S
Sustaining temporal attention prevents habit expression during operant learning in rats.
Scientific Reports 10(1):2020, 10303. DOI:10.1038/s41598-020-67304-y - Takumi Kobayashi, Ryo, C. Yanagita, Kazuhiro Irie
Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/pi interaction.
Bioorganic & Medicinal Chemistry Letters 30:2020, 127657. DOI:10.1016/j.bmcl.2020.127657 - Yasuda M, Ma Y, Okabe S, Wakabayashi Y, Su D, Chang YT, Seimiya H, Tera M, Nagasawa K.
Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization.
Chem Commun 56:2020, 12905-12908. DOI:10.1039/d0cc04957c - Yamamoto, M., Ichinohe, T., Watanabe, A., Kobayashi, A., Zhang, R., Song, J., Kawaguchi, Y., Matsuda, Z. and Inoue, J.
The antimalarial compound atovaquone inhibits Zika and dengue virus infection by blocking E protein-mediated membrane fusion.
Viruses 12:2020, 1475. DOI:10.3390/v1212475 - Tadashi Nakagawa, Satoko Hattori, Tsuyoshi Miyakawa, Keiko Nakayama
The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression.
iScience 23(4):2020, 101030. DOI:10.1016/j.isci.2020.101030 - Mugat B, Nicot S, Chavez CV, Jourdan C, Sato K, Basyuk E, Juge F, Siomi MC, Pelisson A, Chambeyron S.
The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation.
Nature Com. 11:2020, 2828. DOI:10.1038/s41467-020-16635-5 - Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, Yoshida K.
The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
eLife 9:2020, e57381. DOI:10.7554/eLife.57381 - Higashi H, Kato Y, Fujita T, Iwasaki S, Nakamura M, Nishimura Y, Takenaka M, and Shikanai T.
The pentatricopeptide repeat protein PGR3 is required for the translation of petL and ndhG by binding their 5'UTRs.
Plant Cell Physiol. in press:2020, in press. DOI:10.1093/pcp/pcaa180 - Okumura K, Wakabayashi Y
The role of calcium metabolism in keratinocyte differentiation.
Trends in Cancer Research 14:2020, 45-47. - Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Tokunaga F, Tsukagoshi H, Ishikawa O.
The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis.
J Am Acad Dermatol. -:2020, in press. DOI:10.1016/j.jaad.2020.05.051 - Tetsuhisa Otani, Mikio Furuse
Tight Junction Structure and Function Revisited.
Trends in Cell Biology 30(10):2020, 805-817. DOI:10.1016/j.tcb.2020.08.004 - Nakagawa S, Nguyen Pham KT, Shao X, and Doi M
Time-restricted G-protein signaling pathways via GPR176, Gz, and RGS16 set the pace of the master circadian clock in the suprachiasmatic nucleus.
Int J Mol Sci 21:2020, 5055. DOI:10.3390/ijms21145055 - Kurihara Y., Makita Y., Shimohira H., Fujita T., Iwasaki S., and Matsui M.
Translational landscape of protein-coding and non-protein-coding RNAs upon light exposure in Arabidopsis.
Plant Cell Physiol. 61(3):2020, 536-545 . DOI:10.1093/pcp/pcz219 - Naoto Hori, Kazuyuki Okada, Yuki Takakura, Hiroyuki Takano, Naoto Yamaguchi, Noritaka Yamaguchi
Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway.
Journal of Biological Chemistry 295:2020, 8798-8807. DOI:10.1074/jbc.RA120.012781 - Kuboyama K, Shirakawa Y, Kawada K, Fujii N, Ojima D, Kishimoto Y, Yamamoto T, Yamada MK
Visually cued fear conditioning test for memory impairment related to cortical function.
Neuropsychopharmacol. Rep. 40:2020, 371-375. DOI:10.1002/npr2.12146 - 森 拓也, 川原 勲, 額賀翔太，宮川良博, 後藤 桂, 大森 斉, 國安弘基
がん性サルコペニアに対する栄養介入.
奈良医学雑誌 71(1-3):2020, 1-5. - 八尾寛，深沢有吾，冨田浩史，五十嵐敬幸
ラットを用いたオプトジェネティクス（光遺伝学）.
LABIO21 80:2020, 5-8. - Nguyen Pham Khanh Tien、土居雅夫
時計遺伝子の転写のシス制御エレメントに点変異を入れると体内時計はどうなるのか.
Journal of Japanese Biochemical Society 92(5):2020, 735-739. DOI:10.14952/SEIKAGAKU.2020.920735
2019年度
- Kataoka, N., Shima, Y., Nakajima, K., Nakamura, K.
A central master driver of psychosocial stress responses in the rat.
Science 367:2020, 1105-1112. DOI:10.1126/science.aaz4639 - Hamm JP, Shymkiv Y, Mukai J, Gogos JA, Yuste R.
Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setd1a+/- Mice.
Biological Psychiatry in Press:2020, in Press. DOI:10.1016/j.biopsych.2020.01.004 - Wada S, Yanagida J, Sasase H, Zhang T, Li X, Kamii H, Domoto M, Deyama S, Hinoi E, Yamanaka A, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K
Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice.
Neuropharmacology 166:2020, 107968. DOI:10.1016/j.neuropharm.2020.107968 - Ninagawa J, Sumitani M, Nishizawa D, Nagashima M, Mietani K, Abe H, Inoue R, Hozumi J, Tsuchida R, Ikeda K, Yamada Y
Adiponectin receptor 1 gene is potentially associated with severity of postoperative pain but not cancer pain.
Medicine (Baltimore) 99(5):2020, e18924. DOI:10.1097/MD.0000000000018924 - Matsushima S, Shimizu A, Kondo M, Asano H, Ueno N, Nakayama H, Sato N, Komeno M, Ogita H, Kurokawa-Seo M.
Anosmin-1 activates vascular endothelial growth factor receptor and its related signaling pathway for olfactory bulb angiogenesis.
Sci Rep 10:2020, 188. DOI:10.1038/s41598-019-57040-3 - Kataura T, Saiki S, Ishikawa K, Akamatsu W, Sasazawa Y, Hattori N, Imoto M
BRUP-1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson's disease model.
J. Neurochemstry :2020, in press. DOI:10.1111/jnc.14997 - R Ohashi and N Shiina
Cataloguing and selection of mRNAs localized to dendrites in neurons and regulated by RNA-binding proteins in RNA granules.
Biomolecules 10:2020, 167. DOI:10.3390/biom10020167 - Takeda K, Miyamoto Y, Yamamoto H, Ishii A, Hirose S, Yamamoto H.
Clinical features of early myoclonic encephalopathy caused by a CDKL5 mutation.
Brain Dev. 42(1):2020, 73-76. DOI:10.1016/j.braindev.2019.08.003 - Nakahata S , et al, Saito M, Morishita K.
Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma.
Haematologica :2020, in Press. DOI:10.3324/haematol.2019.234096 - Kana Aoki, Shinsuke Satoi, Shota Harada, Seiichi Uchida, Yoh Iwasa, Junichi Ikenouchi
Coordinated Changes in Cell Membrane and Cytoplasm During Maturation of Apoptotic Bleb.
Mol Biol Cell :2020, in press. DOI:10.1091/mbc.E19-12-0691 - Yamaguchi S, Oe A, Nishida KM, Yamashita K, Kajiya A, Hirano S, Matsumoto N, Dohmae N, Ishitani R, Saito K, Siomi H, Nishimasu H, Siomi MC, Nureki O.
Crystal structure of Drosophila Piwi.
Nature Communications 11(1):2020, 858. DOI:10.1038/s41467-020-14687-1 - Takeshita N, Kawade N, Suzuki W, Hara S, Horio F, Ichinose H
Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats.
Neurosci Lett 715:2020, 134656. DOI:10.1016/j.neulet.2019.134656 - Nakata S, Takemoto M, Song W-J.
Differential cortical and subcortical projection targets of subfields in the core region of mouse auditory cortex.
Hearing Research 386:2020, 107876. DOI:10.1016/j.heares.2019.107876 - Han Y, Nakayama J, Hayashi Y, Jeong S, Futakuchi M, Ito E, Watanabe S and Semba K
Establishment and characterization of highly osteolytic luminal breast cancer cell lines by intra-caudal arterial injection.
Genes to Cells 25:2020, 111-123. DOI:10.1111/gtc.12743 - Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Furukawa T & Shoji Natsugoe et al.
FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer.
Oncogenesis 9:2020, 13. DOI:10.1038/s41389-020-0190-7 - Yoo SM, Yamashita SI, Kim H, Na D, Lee H, Kim SJ, Cho DH, Kanki T, Jung YK.
FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.
FASEB J. 34(2):2020, 2944-2957. DOI:10.1096/fj.201901735R - Higa N, Shinsato Y, Kamil M, Hirano T, Takajo T, Shimokawa M, Minami K, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K and Arita K
Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis.
Int J Mol Sci 20:2020, 6355. DOI:10.3390/ijms20246355 - Igarashi R, Yamashita SI, Yamashita T, Inoue K, Fukuda T, Fukuchi T, Kanki T.
Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1.
Sci Rep. 10(1):2020, 1465. DOI:10.1038/s41598-020-58315-w - Shiori Suzuki#, Shuichi Tsutsumi#, Yu Chen#, Chikako Ozeki, Atsushi Okabe, Tatsuya Kawase, Hiroyuki Aburatani and Rieko Ohki*.
Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain.
Cancer Science 111:2020, 451-466. DOI:10.1111/cas.14279 - Wang T, Nakagawa S, Miyake T, Setsu G, Kunisue S, Goto K, Hirasawa A, Okamura H, Yamaguchi Y, and Doi M
Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176.
Sci. Rep. 10:2020, 4429. DOI:10.1038/s41598-020-61370-y - Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.
Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA.
Cell Chemical Biology 27:2020, 186-196.e4. DOI:10.1016/j.chembiol.2019.11.010 - Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, .., Ogita H.
Identification of Transmembrane Protein 168 Mutation in Familial Brugada Syndrome.
FASEB J 34(5):2020, 6399-6417. DOI:10.1096/fj.201902991R - Kato S., Shirai Y., Motozono, C., Kanzaki, H., Mori, S., Kodama, T.
In vivo delivery of an exogenous molecule into murine T lymphocytes using a lymphatic drug delivery system combined with sonoporation.
Biochem Biophys Res Commun. 525(4):2020, 1025-1031. DOI:10.1016/j.bbrc.2020.02.174 - Kawahata T, Kawahara K, Shimokawa M, Sakiyama A, Shiraishi T, Minami K, Yamamoto M, Shinsato Y, Arima K, Hamada T, Furukawa T
Involvement of ribosomal protein L11 expression in sensitivity of gastric cancer against 5-FU.
ONCOLOGY LETTERS 19:2020, 2258-2264. DOI:10.3892/ol.2020.11352 - Wei R, Sugiyama A, Sato Y, Nozumi M, Nishino H, Takahashi M, Saito T, Ando K, Fukuda M, Tomomura M, Igarashi M, *Hisanaga S-i
Isoform-dependent subcellular localization of LMTK1A and LMTK1B, and their roles in axon outgrowth and spine formation.
J Biochem :2020, in press. DOI:10.1093/jb/mvaa019 - Tsutomu Fukuda, Fumito Ishibashi, Masatomo Iwao
Lamellarin alkaloids: Isolation, synthesis, and biological activity.
The Alkaloids: Chemistry and Biology 83:2020, 1-112. DOI:10.1016/bs.alkal.2019.10.001 - Tetsuya Sasaki, Yosuke Takei
Localization Mechanism of Myosin Id, an ASD Risk Gene Product in Dendritic Spines.
Jap J Biological Psych. 31(2):2020, in press. - Hossain MR, Jamal M, Tanoue Y, Ojima D, Takahashi H, Kubota T, Ansary TM, Ito A, Tanaka N, Kinoshita H, Kishimoto Y, Yamamoto T
MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism: An ex vivo HPLC-ECD analysis.
Neurosci. Lett. 716:2020, 134677. DOI:10.1016/j.neulet.2019.134677 - Ishiguro K (Corresponding), Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, Sugimoto M, Fujimura S, Hosokawa M, Chuma S, Ko S.H.M, Araki K, Niwa H
MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells.
Developmental Cell 52(4):2020, 429-445. DOI:10.1016/j.devcel.2020.01.010 - Sugimoto Y., Naniwa K., Aonuma H. and Osuka K.
Microinjection support system for small biological subject.
HardwareX :2020, e00103. DOI:10.1016/j.ohx.2020.e00103 - R Roy, N Shiina, and D O Wang
More dynamic, more quantitative, unexpectedly intricate: Advanced understanding on synaptic RNA localization in learning and memory.
Neurobiology of Learning and Memory 168:2020, 107149 - 107149. DOI:10.1016/j.nlm.2019.107149 - 武山祐士、加藤実、清水保臣、東由香里、玉田聡、井口太郎、山崎健史、魏民、鰐渕英機、仲谷達也
Myeloid-derived suppressor cells are essential partners for immune checkpoint inhibitors in the treatment of cisplatin-resistant bladder cancer.
Cancer Letters :2020, in press. DOI:10.1016/j.canlet.2020.03.013 - Sanchez-Martin P, Sou YS, Kageyama S, Koike M, Waguri S, *Komatsu M.
NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.
EMBO Rep. 21:2020, e48902. DOI:10.15252/embr.201948902 - Matsumura K, Nakazawa T, et al.
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.
Nat Commun 11:2020, 859. DOI:10.1038/s41467-020-14697-z - Kawashima M, Carreras J, Higuchi H, et al
PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma.
Leukemia. :2020, in press. DOI:10.1038/s41375-020-0737-9 - Nakano Y, Hirooka K, Chiba Y, Ueno M, Ojima D, Hossain MR, Takahashi H, Yamamoto T, Kiuchi Y
Retinal ganglion cell loss in 1 kinesin-1 cargo Alcadein α deficient mice.
Cell Death Dis. 11(3):2020, 166. DOI:10.1038/s41419-020-2363-x - Nishiguchi Y, Oue N, Fujiwara-Tani R, Sasaki T, Ohmori H, Kishi S, Shiori Mori S, Mori T, Ideda N, Matsumoto S, Wakatsuki K, Luo Y, Yasui W, Sho M, Kuniyasu H
Role of metastasis-related genes in cisplatin chemoresistance in gastric cancer.
Int J Mol Sci 21:2020, 254. DOI:10.3390/ijms21010254 - Yohei Yamagami, Masashi Kawami, Takamichi Ojima, Sora Futatsugi, Ryoko Yumoto, Mikihisa Takano
Role of plasminogen activator inhibitor-1 in methotrexate-induced epithelial-mesenchymal transition in alveolar epithelial A549 cells.
Biochem Biophys Res Commun 525(3):2020, 543-548. DOI:10.1016/j.bbrc.2020.02.131 - Wakita M, Yamagata A, Shiroshima T, Izumi H, Maeda A, Sendo M, Imai A, Kubota K, Goto-Ito S, Sato Y, Mori H, Yoshida T, Fukai S.
Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α.
Nature Communications 11:2020, 649. DOI:10.1038/s41467-020-14516-5 - (2) Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunag F, Sawasaki T.
Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling.
Biochem Biophys Res Commun. 524(1):2020, 1-7. DOI:10.1016/j.bbrc.2019.12.049 - 横山 玲、樋口 桃子、田邊 航、塚田 信司、内藤 恵、Lu Chen、笠井 淳司、勢力 薫、中澤 敬信、中川 晋作、橋本 謙二、橋本 均、吾郷 由希夫
(S)-norketamine and (2S,6S)-hydroxynorketamine Exert Potent Antidepressant-Like Effects in a Chronic Corticosterone-Induced Mouse Model of Depression.
Pharmacology Biochemistry and Behavior 191:2020, 172876. DOI:10.1016/j.pbb.2020.172876 - Jang MK, Mashima T, Seimiya H
Tankyrase Inhibitors Target Colorectal Cancer Stem Cells via AXIN-Dependent Downregulation of c-KIT Tyrosine Kinase.
Mol Cancer Ther 19(3):2020, 765-776. DOI:10.1158/1535-7163.MCT-19-0668 - Mizutani A, Seimiya H
Tankyrase promotes primary precursor miRNA processing to precursor miRNA.
Biochem Biophys Res Commun 522:2020, 945-951. DOI:10.1016/j.bbrc.2019.11.191 - Luo Y, Kishi S, Sasaki T, Ohmori H, Fujiwara-Tani R, Mori S, Goto K, Nishiguchi Y, Mori T, Kawahara I, Kondoh M, Kuniyasu H
Targeting claudin-4 enhances chemosensitivity in breast cancer.
Cancer Sci :2020, in press. DOI:10.1111/cas.14361 - Yukako Oda, Taichi Sugawara, Yuko Fukata, Yasushi Izumi, Tetsuhisa Otani, Tomohito Higashi, Masaki Fukata, Mikio Furuse
The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts.
Journal of Biological Chemistry 295(13):2020, 4289-4302. DOI:10.1074/jbc.RA119.010491 - Okumura K, Wakabayashi Y
The role of calcium metabolism in keratinocyte differentiation.
Trends in Cancer Research 14:2020, 45-47. - Aonuma H., Mezheritskiy M., Boldyshev B., Totani Y., Vorontsov D., Zakharov I.S., Ito E. and Dyakonova V.
The role of serotonin in the influence of intense locomotion on the behavior under uncertainty in the mollusk Lymnaea stagnalis.
Frontiers in Physiology 11:2020, 221. DOI:10.3389/fphys.2020.00221 - Yue Ma, Keisuke Iida, Kazuo Nagasawa
Topologies of G-quadruplex: Biological functions and regulation by ligands.
Biochem. Biophys. Res. Commun. :2020, in press. DOI:10.1016/j.bbrc.2019.12.103 - Toru Miwa, Kunimasa Ohta, Naofumi Ito, Satoko Hattori, Tsuyoshi Miyakawa, Toru Takeo, Naomi Nakagata, Wen-Jie Song & Ryosei Minoda.
Tsukushi is essential for the development of the inner ear.
Mol Brain 13:2020, 29. DOI:10.1186/s13041-020-00570-z - 及川大輔，伊東秀文，徳永文稔.
直鎖状ユビキチン鎖の神経変性疾患への関与とLUBAC阻害剤の開発.
生化学 91:2020, 28-34. - Wakita D., Kagaya K. and *Aonuma H.
A general model of locomotion of brittle stars with a variable number of arms.
Journal of the Royal Society Interface 17:2019, 162. DOI:10.1098/rsif.2019.0374 - Nagano H, Suzuki S, Koide H, Takeshita N, Sakamoto S, Ban T, Yokote K, Nakamura Y, Ichikawa T, Uno T, Tanaka T.
Aldosterone reduction rate after saline infusion test may be a novel prediction in patients with primary aldosteronism.
J Clin Endocrinol Metab. J Clin Endocrinol Metab. 2019 Oct 19. 105:2019 DOI:10.1210/clinem/dgz092 - Katahira Y, Higuchi H, Matsushita H, Yahata T, Yamamoto Y, Koike R, Ando K, Sato K, Imadome KI, Kotani A.
Increased Granulopoiesis in the Bone Marrow following Epstein-Barr Virus Infection.
Sci Rep. 9(1):2019, 13445. DOI:10.1038/s41598-019-49937 - *Igarashi M
Molecular basis of the functions of the mammalian neuronal growth cone revealed using new methods.
Proc Japan Acad Ser B Phys Biol Sci 95:2019, 358-377. DOI:10.2183/pjab.95.026 - Takahashi N, Nobusue H, Shimizu T, Sugihara E, Yamaguchi-Iwai S, Onishi N, Kunitomi H, Kuroda T, Saya H
Rock inhibition suppresses osteosarcoma tumorigenesis by inducing terminal adipocyte differentiation in chemoresistant stemlike cells.
Cancer Research 79(12):2019, 3088-3099. DOI:10.1158/0008-5472.CAN-18-2693 - 吾郷 由希夫、田邊 航、樋口 桃子、塚田 信司、田中 辰典、五十嵐 久人、横山 玲、勢力 薫、笠井 淳司、中澤 敬信、中川 晋作、橋本 謙二、橋本 均
(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism.
Int J Neuropsychopharmacol 22 (10):2019, 665-674. DOI:10.1093/ijnp/pyz041 - Nishizawa Y, Ikeda R, Yamamoto M , Kawahara K, Shinsato Y, Minami K , Nitta M , Terazono H , Akiyama S, Furukawa T, Takeda Y
5-Aza-2-deoxycytidine Enhances the Sensitivity of 5-Fluorouracil by Demethylation of the Thymidine Phosphorylase Promoter.
Anticancer Res 39:2019, 4129-4136. DOI:10.21873/anticanres.13571 - Masami Ishido
A carrier protein is essential for the action of silver nanoparticles in an animal experiment.
Fund. Toxicol Sci 6:2019, 277-279. DOI:10.2131/fts.6.277 - Miramontes-Gonzalez JP, Hightower M, Zhang K, Kurosaki H, Schork AJ, Biswas N, Vaingankar S, Mahata M, Lipkowitz MS, Ichinose H, O'Connor DT
A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function.
Sci Rep 9:2019, 5055. DOI:10.1038/s41598-019-41504-7 - Saito M, Okumura K, Isogai E, Araki K, Tanikawa C, Matsuda K, Kamijo T, Kominami R, Wakabayashi Y.
A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway.
Journal of Investigative Dermatology 139(7):2019, 1459-1469. DOI:10.1016/j.jid.2018.12.027 - Shigetomi E, Saito K, Sano F, Koizumi S.
Aberrant Calcium Signals in Reactive Astrocytes: A Key Process in Neurological Disorders.
Int J Mol Sci 20:2019, 996. DOI:10.3390/ijms20040996 - Koki Mimura, Tomofumi Oga, Tetsuya Sasaki, Koichi Saito, Izuru Miyawaki, Tetsuya Suhara, Ichio Aoki, Noritaka Ichinohe.
Abnormal axon guidance signals and reduced interhemispheric connection via anterior commissure in neonates of marmoset ASD model.
Neuroimage 0.260416666666667:2019, 243-251. DOI:10.1016/j.neuroimage.2019.04.006 - 林 崇
AMPA受容体の分子修飾変化とてんかん.
Clinical Neuroscience 37:2019, 1268-1270. - Huber J, Obata M, Gruber J, Akutsu M, L?hr F, Rogova N, Guntert P, Dikic I, Kirkin V, Komatsu M, Dotsch V, Rogov VV.
An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.
Autophagy 16:2019, 256-270. DOI:10.1080/15548627.2019.1606637 - Yamashiro H, Negishi M, Kinoshita T, Ishizu H, Ohtani H, Siomi MC.
Armitage determines Piwi－piRISC processing from precursor formation and quality control to inter‐organelle translocation.
EMBO Report 21(2):2019 DOI:10.15252/embr.201948769 - Mori T, Oku K, Miyagawa Y, Nukaga S, Kanto S, Kudo E, Imagita H, Kawahara I
Association between changes in subcutaneous fat mass and heart failure-induced cachexia: a case report.
J Phys Ther Sci 31:2019, 462-465. DOI:10.1589/jpts.31.462. - Matsumura K, Nakazawa T, et al.
Autism-associated protein kinase D2 regulates embryonic cortical neuron development.
Biochem Biophys Res Commun. 519:2019, 626-632. DOI:10.1016/j.bbrc.2019.09.048 - Yang, C-C., Kato, H., Shindo, M. and *Masai. H.
Cdc7 activates replication checkpoint by phosphorylating the Chk1 binding domain of Claspin in human cells.
E-life 8:2019, e50796. DOI:10.7554/eLife.50796 - Ito, S., Goto, H., Kuniyasu, K., Shindo, M., Yamada, M., Tanaka, K., Toh, G-K., Sawa, S., Inagaki, M., Bartek, B., and *Masai. H.
Cdc7 kinase stimulates Aurora B kinase in M-phase.
Scientific Reports 9:2019, 18622. DOI:10.1038/s41598-019-54738-2 - Goto A, Ishii A, Shibata M, Ihara Y, Cooper EC, Hirose S.
Characteristics of KCNQ2 variants causing either benign neonatal epilepsy or developmental and epileptic encephalopathy.
Epilepsia 60(9):2019, 1870-1880. DOI:10.1111/epi.16314 - Tetsuhisa Otani, Thanh Phuong Nguyen, Shinsaku Tokuda, Kei Sugihara, Taichi Sugawara, Kyoko Furuse, Takashi Miura, Klaus Ebnet, Mikio Furuse
Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity.
Journal of Cell Biology 218:2019, 3372-3396. DOI:10.1083/jcb.201812157 - Nakashima C, Yamamoto K, Kishi S, Sasaki T, Ohmori H, Fujiwara-Tani R, Mori S, Kawahara I, Nishiguchi Y, Mori T, Kondoh M, Luo Y*, Tadaaki K*, Kuniyasu H
Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas.
Oncotarget 11:2019, 309-321. DOI:10.18632/oncotarget.27424 - Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy.
Pathobiology 86:2019, 182-189. DOI:10.1159/000496027 - Hirabayashi K, Uehara DT, Abe H, Ishii A, Moriyama K, Hirose S, Inazawa J.
Copy number variation analysis in 83 children with early-onset developmental and epileptic encephalopathy after targeted resequencing of a 109-epilepsy gene panel.
J Hum Genet 64(11):2019, 1097-1106. DOI:10.1038/s10038-019-0661-x - Takemoto M, Song W-J.
Cue-dependent safety and fear learning in a discriminative auditory fear conditioning paradigm in the mouse.
Learning & Memory 26:2019, 284-290. DOI:10.1101/lm.049577.119 - Kano T., Kanauchi D., Aonuma H., Clark E.G. and IshiguroA.
Decentralized control mechanism for determination of moving direction in brittle stars with penta-radially symmetric body.
Frontiers in Neurorobotics 13:2019, 66. DOI:10.3389/fnbot.2019.00066 - Kano M, Watanabe T.
Developmental synapse remodeling in the cerebellum and visual thalamus.
F1000Res. 8:2019 DOI:10.12688/f1000research.18903.1 - Wakita D, Hayase Y and Aonuma H.
Different synchrony in rhythmic movement caused by morphological difference between five- and six-armed brittle stars.
Scientific Reports 9:2019, 8298. DOI:10.1038/s41598-019-44808-w - Rios A, Soma S, Yoshida J, Nonomura S, Kawabata M, Sakai Y, Isomura Y
Differential changes in the lateralized activity of identified projection neurons of motor cortex in hemiparkinsonian rats.
eNeuro 6(4):2019 DOI:10.1523/ENEURO.0110-19.2019 - Chowdhury S, Hung CJ, Izawa S, Inutsuka A, Kawamura M, Kawashima T, Bito H, Imayoshi I, Abe M, Sakimura K, *Yamanaka A
Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice.
eLife 8:2019, e44927. DOI:10.7554/eLife.44927 - Ishizu H, Kinoshita T, Hirakata S, Komatsuzaki C, Siomi MC.
Distinct and Collaborative Functions of Yb and Armitage in Transposon-Targeting piRNA Biogenesis.
Cell Report 27(6):2019, 1822-1835. DOI:10.1016/j.celrep.2019.04.029 - Konno, M., Koseki, J., Ishii, H
Distinct Methylation Levels of Mature MicroRNAs in Gastrointestinal Cancers.
Nature Commun 10:2019, 3888. DOI:10.1038/s41467-019-11826-1 - Kanemaru Y, Natsumeda M, Okada M, Saito R, Watanabe J, Saito S, Tsukamoto Y, Oishi M, Saito H, Nagahashi M, Sasaki T, Hashizume R, Kakita A, Fujii Y, et.al.
Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy.
Acta Neuropathologica Communications 7:2019, 119. DOI:10.1186/s40478-019-0774-7 - Yoshitomi S, Takahashi Y, Yamaguchi T, Imai K, Ishii A, Hirose S, Inoue Y.
Efficacy and tolerability of perampanel in pediatric patients with Dravet syndrome.
Epilepsy Res. 154:2019, 34-38. DOI:10.1016/j.eplepsyres.2019.02.014 - Fukabori, R., Iguchi, Y., Kato, S.,.., Benton, R., & Kobayashi, K.
Enhanced emotional memory retrieval by chemogenetic activation of locus coeruleus norepinephrine neurons.
bioRxiv. Advance online publication. :2019 DOI:10.1101/831313 - Osumi K, Sato K, Murano K, Siomi H, Siomi MC.
Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing.
EMBO Report 20(12):2019 DOI:10.15252/embr.201948296 - Ohmori H, Kawahara I, Mori T, Nukaga S, Luo Y, Kishi S, Fujiwara-Tani R, Mori S, Goto K, Sasaki T, Kuniyasu H
Evaluation of parameters for cancer-induced sarcopenia in patients autopsied after death from colorectal cancer.
Pathobiology 86:2019, 306-314. DOI:10.1159/000503037 - Igarashi M, Okuda S
Evolutionary analysis of proline-directed phosphorylation sites in the mammalian growth cone identified using phosphoproteomics.
Mol Brain 12:2019, 53. DOI:10.1186/s13041-019-0476-x - Nakamoto C, Konno K, Miyazaki T, Nakatsukasa E, Natsume R, Abe M, Kawamura M, Fukazawa Y, Shigemoto R, Yamasaki M, Sakimura K, Watanabe M.
Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain.
Journal of Comparative Neurology 528(6):2019, 1003-1027. DOI:10.1002/cne.24792 - 26. Tanaka S, Ishihara N, Suzuki S, Watanabe Y, Nagayama D, Yamaguchi T, Ohira M, Saiki A, Tanaka T, Tatsuno I.
Fatty acid desaturase 2 is up-regulated by the treatment with statin through geranylgeranyl pyrophosphate-dependent Rho kinase pathway in HepG2 cells.
Sci Rep. 9:2019, 10009. DOI:10.1038/s41598-019-46461-9 - Kano T., Kanauchi D., Ono T, Aonuma H and Ishiguro A.
Flexible coordination of flexible limbs: decentralized control scheme for inter- and intra-limb coordination in brittle stars’ locomotion.
Frontiers in Neurorobotics 13:2019, 104. DOI:10.3389/fnbot.2019.00104 - Chowdhury S, Matsubara T, Miyazaki T, Ono D, Fukatsu N, Abe M, Sakimura K, Sudo Y, Yamanaka A*
GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice .
eLife 8:2019, e44928. DOI:10.7554/eLife.44928 - Murata K, Kinoshita T, Fukazawa Y, Kobayashi Ke,
Kobayashi Ka, Miyamichi K, Okuno H, Bito H, Sakurai Y, Yamaguchi M, Mori K, Manabe H.
GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice.
Scientific reports 9:2019, 7132. DOI:10.1038/s41598-019-43580-1 - Koichiro Abe, Allison Cox, Nobuhiko Takamatsu, .. , Alexander Bassuk, Helmut Fuchs, Polly Ferguson, Martin Hrabe de Angelis
Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans.
PNAS 116:2019, 11872-11877. DOI:10.1073/pnas.1819825116 - Ryo Tanifuji, Kaori Tsukakoshi, Kazunori Ikebukuro, Hideaki Oikawa, Hiroki Oguri
Generation of C5-desoxy analogs of tetrahydroisoquinoline alkaloids exhibiting potent DNA alkylating ability.
Bioorg. Med. Chem. Lett. 29:2019, 1807-1811. DOI:10.1016/j.bmcl.2019.05.009 - Mori T, Ohmori H, Luo Y, Mori S, Miyagawa Y, Nukaga S, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Kawahara I, Kuniyasu H
Giving combined medium-chain fatty acids and glucose protects against cancer-associated skeletal muscle atrophy.
Cancer Sci 110:2019, 3391-3399. DOI:10.1111/cas.14170 - Chernyshova K, Inoue K, Yamashita SI, Fukuchi T, Kanki T.
Glaucoma-Associated Mutations in the Optineurin Gene Have Limited Impact on Parkin-Dependent Mitophagy.
Invest Ophthalmol Vis Sci. 60(10):2019, 3625-3635. DOI:10.1167/iovs.19-27184 - Nakashima T, Yasuda K, Kobayashi M, Wada H, Ishii A, Hirose S.
Heart rate variability in a patient with alternating hemiplegia.
Intractable Rare Dis Res. 8(2):2019, 134-137. DOI:10.5582/irdr.2019.01060 - Matsuzaka T, Kuba M, Koyasu S, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H.
Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice.
Hepatology 71(5):2019, 1609-1625 DOI:10.1002/hep.30953 - Horigome Y, Ida-Yonemochi H, Waguri S, Shibata S, Endo N, Komatsu M.
Horigome Y, Ida-Yonemochi H, Waguri S, Shibata S, Endo N, Komatsu M.
Autophagy 16:2019, 501-511. DOI:10.1080/15548627 - Nagatsu T, Nakashima A, Ichinose H, Kobayashi K
Human tyrosine hydroxylase in Parkinson's disease and in related disorders.
J Neural Transm 126:2019, 397-409. DOI:10.1007/s00702-018-1903-3 - Tamura N, Kageyama S, Komatsu M, Waguri S.
Hyperosmotic Stress Induces Unconventional Autophagy Independent of the Ulk1 Complex.
Mol Cell Biol. 39:2019, e00024-19. DOI:10.1128/MCB.00024-19 - Hasegawa T, Kikuta J, Sudo T, Matsuura Y, Matsui T, Simmons S, Ebina K, Hirao M, Okuzaki D, Yoshida Y, Hirao A, Kalinichenko VV, Yamaoka K, Takeuchi T, Ishii M.
Identification of a Novel Arthritis-Associated Osteoclast Precursor Macrophage Regulated by FoxM1.
Nat Immunol 20:2019, 1631-1643 . DOI:10.1038/s41590-019-0526-7 - shihara E, Takahashi S, Fukaya R, Ohta S, Yoshida K, Toda M.
Identification of KLRC2 as a candidate marker for brain tumor-initiating cells.
Neurol Res 41(11):2019, 1043-1049. DOI:10.1080/01616412.2019.1672390 - Nagai Y, Nishitani N, Yasuda M, Ueda Y, Fukui Y, Andoh C, Shirakawa H,
Nakagawa T, Inoue KI, Nagayasu K, Kasparov S, Nakamura K, Kaneko S.
Identification of neuron-type specific promoters in monkey genome and their functional validation in mice.
Biochemical and biophysical research communications 518(4):2019, 614-624. DOI:10.1016/j.bbrc.2019.08.101 - Keisuke Otake, Kana Yamada, Kazuki Miura, Yukiko Sasazawa, So Miyazaki, Yuki Niwa, Akihiro Ogura, Ken-ichi Takao, Siro Simizu
Identification of topoisomerases as molecular targets of cytosporolide C and its analog.
Bioorganic & Medicinal Chemistry 27:2019, 3334-3338. DOI:10.1016/j.bmc.2019.06.014 - Tatsuya Kawase, Yu Chen, Rieko Ohki*.
IER5 Is a p53-Regulated Activator of HSF1 That Contributes to Promotion of Cancer.
Heat Shock Proteins 17:2019, 253-272. - Kawakami Y, Ohta S, Sayem MA, Tsukamoto N, Yaguchi T
Immune-resistant mechanisms in cancer immunotherapy.
Int J Clin Oncol. :2019, in press. DOI:10.1007/s10147-019-01611-x - Mashima T, Iwasaki R, Kawata N, Kawakami R, Kumagai K, Migita T, Sano T, Yamaguchi K, Seimiya H.
In silico chemical screening identifies epidermal growth factor receptor as a therapeutic target of drug-tolerant CD44v9-positive gastric cancer cells.
Br J Cancer 121:2019, 846-856. DOI:10.1038/s41416-019-0600-9 - Sonoko Chikamatsu, Ken Saijo, Hiroo Imai, Koichi Narita, Yoshifumi Kawamura, Tadashi Katoh, Chikashi Ishioka
In Vitro and in Vivo antitumor activity and the mechanism of siphonodictyal B in human colon cancer cells.
Cancer Medicine 8:2019, 5662-5672. DOI:10.1002/cam4.2409 - Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T, Sasaki T.
Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression.
Sci Rep. :2019 DOI:10.1038/s41598-019-49744-3 - Takamura, S., Kato, S., Motozono, C., Shimaoka, T., Ueha, S., Matsuo, K., Miyauchi, K., Nakayama, T., Tomura, M., Matsushima, K., Kubo, M., Miyazawa, M.
Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung.
J Exp Med. 216:2019, 2736-2747. DOI:10.1084/jem.20190557 - Okada T, Minato N, Kanemoto SY, Zempo N, Saiga K, Namikawa K, Kanno S, Ueno H.
Intimal regeneration after coronary endarterectomy and onlay grafting in coronary artery bypass grafting.
General thoracic and cardiovascular surgery 67(8):2019, 677-683. DOI:10.1007/s11748-019-01083-w - Toyokuni S
Iron Addiction with Ferroptosis-resistance in Asbestos-induced Mesothelial Carcinogenesis: Toward the Era of Mesothelioma Prevention.
Free Radic Biol Med 133:2019, 206-215. DOI:10.1016/j.freeradbiomed.2018.10.401 - Takei Y, Tome S, Sasaki T.
KIF17-mediated transport of NMDA receptors and schizophrenia.
Jap J Biological Psych. 30(3):2019, 101-104. DOI:10.11249/jsbpjjpp.30.3_101 - Yasuo Higurashi, Marc A. Maier, Katsumi Nakajima, Kazunori Morita, Soichiro Fujiki, Shinya Aoi, Futoshi Mori, Akira Murata, Masahiko Inase
Locomotor kinematics and EMG activity during quadrupedal versus bipedal gait in the Japanese macaque.
J. Neurophysiol 122:2019, 398-412. DOI:10.1152/jn.00803.2018 - Yoshida K, Gi M, Fujioka M, Teramoto I, Wanibuchi H
Long-term administration of excess zinc impairs learning and memory in aged mice.
Journal of Toxicological Sciences 44(10):2019, 681-691. DOI:10.2131/jts.44.681 - Takahashi SS, Sou YS, Saito T, Kuma A, Yabe T, Sugiura Y, Lee HC, Suematsu M, Yokomizo T, Koike M, Terai S, Mizushima N, Waguri S, Komatsu M.
Loss of autophagy impairs physiological steatosis by accumulation of NCoR1.
Life Sci Alliance. 3:2019, e201900513. DOI:10.26508/lsa.201900513 - Sato M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T, Ito T, and OikeY
Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice.
Circ J 83(2):2019, 368-378. DOI:10.1253/circj.CJ-18-0925 - Kawahara I, Goto K, Kodama K, Luo Y, Fujiwara-Tani R, Mori T, Miyagawa Y, Tanaka H, Kodama H, Hirayama A, Hosoito N, Taniguchi Y, Miki Y, Kuniyasu H
Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle.
Pathobiology 86:2019, 254-262. DOI:10.1159/000501524 - Saori Shinoda, Sho Kitagawa, Shinichi Nakagawa, Fan-Yan Wei, Kazuhito Tomizawa, Kimi Araki, Masatake Araki, Takeo Suzuki and Tsutomu Suzuki,
Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs.
Nuc. Acids Res. 47:2019, 8734-8745. DOI:10.1093/nar/gkz575 - Jane S. Weng, Takanori Nakamura, Hisashi Moriizumi, Hiroshi Takano, Ryoji Yao & Mutsuhiro Takekawa
MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing.
Communications Biology 2:2019, 227. DOI:10.1038/s42003-019-0478-3 - Fujikawa A, Noda Y, Yamamoto H, Tanga N, Sakaguchi G, Hattori S, Song W-J, Sora I, Nabeshima T, Katsuura G, Noda M.
Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty.
PLoS ONE 14:2019, e0221205. DOI:10.1371/journal.pone.0221205 - Shinozaki Y, Danjo Y, Koizumi S.
Microglial ROCK is essential for chronic methylmercury-induced neurodegeneration.
J Neurochem 151:2019, 64-78. DOI:10.1111/jnc.14817 - Hikosaka, O., Yasuda, M., Nakamura, K., Isoda, M., Kim, H. F., Terao, Y., Amita, H., Maeda, K.
Multiple neuronal circuits for variable object-action choices based on short- and long-term memories.
Proceedings of the National Academy of Sciences of the United States of America 116 (52):2019, 26313-26320. DOI:10.1073/pnas.1902283116 - Yamada N, .., Zankov DP, Shimizu A, .., Ogita H, .., Takashima S.
Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation.
Circulation 139:2019, 2157-2169. DOI:10.1161/CIRCULATIONAHA.118.036761 - Momosaki K, Kido J, Yoshida S, Sugawara K, Miyamoto T, Inoue T, Okumiya T, Matsumoto S, Endo F, Hirose S, Nakamura K.
Newborn screening for Pompe disease in Japan: report and literature review of mutations in the GAA gene in Japanese and Asian patients.
J Hum Genet. 64(8):2019, 741-755. DOI:10.1038/s10038-019-0603-7 - Doi M, Shimatani H, Atobe Y, Murai I, Hayashi H, Takahashi Y, Fustin JM, Yamaguchi Y, Kiyonari H, Koike N, Yagita K, Lee C, Abe M, Sakimura K, and Okamura H
Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity.
Nature Commun. 10:2019, 2563. DOI:10.1038/s41467-019-10532-2 - Shotaro Yamano, Makoto Kimura, Yu Chen, Naoko Imamoto* and Rieko Ohki*.
Nuclear import of IER5 is mediated by a classical bipartite nuclear localization signal and is required for HSF1 full activation.
Experimental Cell Research 386(1):2019, 111686. DOI:10.1016/j.yexcr.2019.111686 - Murano K, Iwasaki YW, Ishizu H, Mashiko A, Shibuya A, kondo S, Adachi S, Suzuki S, Saito K, Natsume T, Siomi MC, Siomi H
Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing.
EMBO J 38(17):2019, e102870. DOI:10.15252/embj.2019102870 - Ghandour K, Ohkawa N, Chung C, Fung A, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, Nishizono H, Matsuo M, Osanai M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Kitamura T, Fukai T, Inokuchi K
Orchestrated ensemble activities constitute a hippocampal memory engram.
Nature Communications 10:2019, 2637. DOI:10.1038/s41467-019-10683-2 - Fujii T, Chiba Y, Nakayama-Imaohji H, Onishi S, Tanaka A, Katami H, Kaji T, Ieiri S, Miki T, Ueno M, Kuwahara T, Shimono R
Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.
J Pediatr Surg 54(12):2019, 2514-2519. DOI:10.1016/j.jpedsurg.2019.08.048 - Ishikawa Y, Okada M, Honda A, Ito Y, Tamada A, Endo N, *Igarashi M
Phosphorylation sites of microtubule-associated protein 1B (MAP1B) involved in axon growth and regeneration.
Mol Brain 12:2019, 93. DOI:10.1186/s13041-019-0510-z - Sanchez-Martin P, Komatsu M.
Physiological Stress Response by Selective Autophagy.
J Mol Biol. 432:2019, 53-62. DOI:10.1016/j.jmb.2019.06.013 - 早田 敦子、加茂 俊彦、貴島 春衣、勢力 薫、尾形 勝弥、吾郷 由希夫、中澤 敬信、新谷 勇介、東野 功典、永安 一樹、新谷 紀人、笠井 淳司、James A Waschek、橋本均
Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation.
Journal of Neuroscience 39 (22):2019, 4208-4220. DOI:10.1523/JNEUROSCI.2468-18.2019 - Watanabe T, Suzuki H, Kano M
Postnatal Development of Cerebellar Neural Circuits.
Brain Nerve. 12:2019, 1373-1383. DOI:10.11477/mf.1416201457 - Sasaki T, Komatsu Y, Yamamori T.
Prefrontal-Enriched SLIT1 Expression in Primate Cortex and its Alteration during Cortical Development.
Jap J Biological Psych. 30(2).:2019, 81-85. DOI:10.11249/jsbpjjpp.30.2_81 - Okumura A, Shimojima K, Kurahashi H, Numoto S, Shimada S, Ishii A, Hirose S, Yamamoto T et al.
PRRT2 mutations in Japanese patients with benign infantile epilepsy and paroxysmal kinesigenic dyskinesia.
Seizure 71:2019, 43835. DOI:10.1016/j.seizure.2019.05.017 - Baba M, Nakazawa T, et al.
Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.
Neuropsychopharmacology 44:2019, 2125-2135. DOI:10.1038/s41386-019-0441-5 - Inoue M, Takeuchi A, Manita S, Horigane SI, Sakamoto M, .. , Bito H.
Rational engineering of XCaMPs, a multicolor GECI suite for in vivo imaging of complex brain circuit dynamics.
Cell 177:2019, 1346-1360. DOI:10.1016/j.cell.2019.04.007 - Mukai J, Cannavo E, Crabtree GW, Sun Z, Diamantopoulou A, Thakur P, Chang CY, Cai Y, Lomvardas S, Takata A, Xu B, Gogos JA.
Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice.
Neuron 104:2019, 471-487. DOI:10.1016/j.neuron.2019.09.014 - Miyake T, and Doi M
Reconstitution of Organismal Liver Clock Function Requires Light.
Trends Endocrinol Metab. 30:2019, 569-571. DOI:10.1016/j.tem.2019.07.017 - Isokawa M, Sassa T, Hattori S, Miyakawa T, Kihara A
Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1.
FASEB BioAdvances 1:2019, 747-759. DOI:10.1096/fba.2019-00067 - Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, Ohmura Y, Mizoguchi H, Kimura K, Yoshioka M, Terao A, Kilduff TS, Yamanaka A*
REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories. .
Science 365(6459):2019, 1308-1313. DOI:10.1126/science.aax9238 - Yoshiyuki Kasahara
Yasufumi Sakakibara
Takashi Hiratsuka
Yuki Moriya
Klaus‐Peter Lesch
F. Scott Hall
George R. Uhl
Ichiro Sora
Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice.
Neuropsychopharmacol Rep 39(2):2019, 130-133. DOI:10.1002/npr2.12049. - Hirakata S, Ishizu H, Fujita A, Tomoe Y, Siomi MC.
Requirements for multivalent Yb body assembly in transposon silencing in Drosophila.
EMBO Rep. 20(7):2019, e47708. DOI:10.15252/embr.201947708 - Maho Tsubota, ..Shuji Wakatsuki,.., Atsufumi Kawabata
Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants.
J Neuroinflamm 16:2019, 199. DOI:10.1186/s12974-019-1581-6 - Nie X, Kitaoka S, Shinohara M, Kakizuka A, Narumiya S, Furuyashiki T.
Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance.
Sci Rep 9:2019, 17548. DOI:10.1038/s41598-019-54082-5 - Kensuke Yamamoto, Yusei Mohara, Yuichiro Mutoh, and Shinichi Saito
Ruthenium-Catalyzed (Z)-Selective Hydroboration of Terminal Alkynes with Naphthalene-1,8-diaminatoborane.
J AM CHEM SOC 141:2019, 17042-17047. DOI:10.1021/jacs.9b06910 - Tomomi Sanagi, Tetsuya Sasaki, Takafumi Minamimoto, Shin-ichi Kohsaka, and Noritaka Ichinohe
Segmented Iba1-positive processes of microglia in autism model marmosets.
Front Cell Neurosci, section Cellular Neuropathology 13:2019, 344-350. DOI:10.3389/fncel.2019.00344 - Toshio Fujino and Tetsuya Mitsudomi
Sensitivity and Resistance of MET Exon 14 Mutations in Lung Cancer to Eight MET Tyrosine Kinase Inhibitors In Vitro.
Journal of thoracic oncology 14:2019, 1753, 1765. DOI:10.1016/j.jtho.2019.06.023 - Sobuz SU, Sato Y, Yoshizawa T, Karim MF, Ono K, Sawa T, Miyamoto Y, Oka Y, Yamagata K
SIRT7 regulates the nuclear export of NF-kB p65 by deacetylating Ran.
BBA - Mol Cell Res 1866:2019, 1355-1367. DOI:10.1016/j.bbamcr.2019.05.001 - Numa C, Nagai H, Taniguchi M, Nagai M, Shinohara R, Furuyashiki T.
Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex.
Sci Rep 9:2019, 16670. DOI:10.1038/s41598-019-52997-7 - Kikuta S, Iguchi Y, Kakizaki T, Kobayashi K, Yanagawa Y, Takada M, Osanai M
Store-operated calcium channels are involved in spontaneous slow calcium oscillations in striatal neurons.
Frontiers in Cellular Neuroscience 13:2019, 547. DOI:10.3389/fncel.2019.00547 - Shinohara, F., Asaoka, Y., Kamii, H., Minami, M., Kaneda, K.
Stress augments the rewarding memory of cocaine via the activation of brainstem-reward circuitry.
Addiction Biology 24:2019, 509-521. DOI:10.1111/adb.12617 - Yuichiro Mutoh, Kensuke Yamamoto, Shinichi Saito
Suzuki-Miyaura Cross-Coupling of 1,8-Diaminonaphthalene (dan)-Protected Arylboronic Acids.
ACS CATAL 10:2019, 352-357. DOI:10.1021/acscatal.9b03667 - Chi-Wai Fung, Go Fukada, Yuichiro Mutoh, Noriko Tsuchida, Shinchi Saito
Synthesis and properties of anionic ruthenium thionitrosyl and selenonitrosyl complexes that contain tetraanionic 2-hydroxybenzamidobenzene ligands.
DALTON TRANSACTIONS 49:2019, 613-624. DOI:10.1039/C9DT04219A - Yamazaki, Y.; Mizuma, R.; Abe, H.; Aoki, R.; Mutoh, Y.; Saito, S.
Synthesis of Helical 3,3′-Bridged-2,2′-bibenzo[g]quinolines.
CHEMISTRY LETTERS 49:2019, 133-136. DOI:10.1246/cl.190803 - Takuma Watanabe, Yuichiro Mutoh, and Shinichi Saito
Synthesis of lactone-fused pyrroles by ruthenium-catalyzed 1,2-carbon migration-cycloisomerization.
ORG BIOMOL CHEM 18:2019, 81-85. DOI:10.1039/C9OB02363A - Nishiguchi Y, Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Kishi S, Mori S, Goto K, Yasui W, Sho M*, Kuniyasu H
Targeting claudin-4 enhances CDDP-chemosensitivity of gastric cancer.
Oncotarget 10:2019, 2189-2202. DOI:10.18632/oncotarget.26758 - Sasaki T, Fujiwara-Tani R, Kishi S, Mori S, Luo Y, Ohmori H, Goto K, Nishiguchi Y, Mori T, Sho M, Kondo M, Kuniyasu H
Targeting claudin-4 enhances chemosensitivity of pancreatic ductal carcinomas.
Cancer Med 8:2019, 6700-6708. DOI:10.1002/cam4.2547 - Braganza, CD., Shibata, K., Fujiwara, A., Motozono, C., Sonoda, KH., Yamasaki, S., Stocker, BL., Timmer, MSM
The effect of MR1 ligand glycol-analogues on mucosal-associated invariant T (MAIT) cell activation.
Org Biomol Chem. 17:2019, 8992-9000. DOI:10.1039/c9ob01436e - Kondo T, Ando M, Nagai N, Tomisato W, Srirat T, Liu B, Mise-Omata S, Ikeda M, Chikuma S, Yoshimura A et al
The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells.
Cancer Res 80:2019, 471-483. DOI:10.1158/0008-5472.CAN-19-1196 - Ahmat Amin MKB, Shimizu A, Ogita H.
The pivotal roles of the epithelial membrane protein family in cancer invasiveness and metastasis.
Cancers 11:2019, E1620. DOI:10.3390/cancers11111620 - Rajput SK, Kumar M, Quan X, Morita M, Furuyashiki T, Awatsuji Y, Tajahuerce E, Matoba O.
Three-dimensional fluorescence imaging using the transport of intensity equation.
J Biomed Opt 25:2019, 1-7. DOI:10.1117/1.JBO.25.3.032004 - Hirao N, Iwata T, Tanaka K, Nishio H, Nakamura M, Morisada T, Morii K, Maruyama N, Katoh Y, Yaguchi T, Ohta S, Kukimoto I Aoki D, Kawakami Y
Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter.
Gynecol Oncology 155(2):2019, 31478-31487. DOI:10.1016/j.ygyno.2019.08.026 - Williams RH, Tsunematsu T, Thomas AM, Bogyo K, Yamanaka A*, Kilduff TS*.
Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy. .
J Neurosci 39(47):2019, 9435-9452. DOI:10.1523/JNEUROSCI.0311-19.2019 - Inami C, Tanihira H, Kikuta S, Ogasawara O, Sobue K, Kume K, Osanai M, Ohsawa M
Visualization of brain activity in a neuropathic pain model using quantitative activity-dependent manganese magnetic resonance imaging.
Frontiers in Neural Circuits 13:2019, 74. DOI:10.3389/fncir.2019.00074 - 勢力 薫、笠井 淳司、中澤 敬信、丹生 光咲、中 雄一郎、田沼 将人、五十嵐 久人、山浦 港生、早田 敦子、吾郷 由希夫、橋本均
Whole-brain Block-Face Serial Microscopy Tomography at Subcellular Resolution Using FAST.
Nat Protoc 14 (5):2019, 1509-1529. DOI:10.1038/s41596-019-0148-4 - Sadaiwa Yorimoto, Akira Tsubouchi, Haruki Mizoguchi, Hideaki Oikawa, Yoshiaki Tsunekawa, Tomoya Ichino, Satoshi Maeda and Hiroki Oguri
Zn(OTf)2-mediated annulations of N-propargylated tetrahydrocarbolines: divergent synthesis of four distinct alkaloidal scaffolds.
Chemical Science 10:2019, 5686-5698. DOI:10.1039/C9SC01507H - 佐藤信吾
骨転移とマイクロRNA.
BIO Clinica 34(9):2019, 794-798. - 菊田 里美, 笠原 二郎, 小山内 実
定量的マンガン造影MRI を用いた疾患モデル動物の神経活動計測.
日本放射線技術学会雑誌 75(8):2019, 799-804.
2018年度
- Hiroaki Tagaya, Kosuke Ishikawa, Yoshito Hosokawa, Shun Kobayashi, Yukino Ueoka, Mayuna Shimada, Yasuko Ohashi, Hirofumi Mikami, Mizuki Yamamoto, Tatsuya Ihara, Kentaro Kumazawa, Kosuke Sugihara, Naoki Goshima, Shinya Watanabe and Kentaro Semba
A method of producing genetically manipulated mouse mammary gland.
Breast Cancer Research 21:1, 2019. DOI:10.1186/s13058-018-1086-8 - Saito M, Okumura K, Isogai E, Araki K, Tanikawa C, Matsuda K, Kamijo T, Kominami R, Wakabayashi Y.
A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway.
Journal of Investigative Dermatology 139(7):1459-1469, 2019. DOI:10.1016/j.jid.2018.12.027 - Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Tani H, Mito T, Matsumoto H, Miyakawa T, Nakada K.
Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior.
Journal of Neuroscience 39(9):1588-1604, 2019. DOI:10.1523/JNEUROSCI.2139-18.2018 - Kurosaki H, Yamaguchi K, Man-Yoshi K, Muramatsu SI, Hara S, Ichinose H
Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP.
Neurochemistry International 125:16-24, 2019. DOI:10.1016/j.neuint.2019.02.005 - Saitoh, S. I., Y. M. Saitoh, K. Kontani, K. Sato, and K. Miyake.
ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus.
Int Immunol. :in press, 2019. DOI:10.1093/intimm/dxy084 - Egawa R, Yawo H.
Analysis of Neuro-Neuronal Synapses Using Embryonic Chick Ciliary Ganglion via Single-Axon Tracing, Electrophysiology, and Optogenetic Techniques.
Curr Protoc Neurosci. :e64, 2019. DOI:10.1002/cpns.64 - Ikeda K, Kaneko R Yanagawa Y, Ogawa M,et al.
Analysis of the neuronal network of the medullary respiratory center in transgenic rats expressing archaerhodopsin-3 in Phox2b-expressing cells.
Brain Res Bull 144:39-45, 2019. DOI:10.1016/j.brainresbull.2018.11.005 - Nam SA, Kim WY, Kim JW, Park SH, Kim HL, Lee MS, Komatsu M, Ha H, Lim JH, Park CW, Yang CW, Kim J, Kim YK.
Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway.
Cell Death Dis. 10(2):535-540, 2019. DOI:10.1038/s41419-019-1356-0 - Saito T., Komatsu M. (19人中19番目)
Autophagy regulates lipid metabolism through selective turnover of NCoR1.
Nat.Commun. 10:1567, 2019. DOI:10.1038/s41467-019-08829-3 - Hashimoto K, Sato S, Ochi H, Takeda S, Futakuchi M
Calvarial Bone Implantation and in vivo Imaging of Tumor Cells in Mice.
Bio Protoc 9(3):e3151, 2019. DOI:10.21769/BioProtoc.3151 - Akichika S., Hirano S., Shichino Y., Suzuki T., Nishimasu H., Ishitani R., Sugita A., Hirose Y., Iwasaki S., Nureki O., and Suzuki T.
Cap-specific terminal N6-methylation of RNA by an RNA polymerase II-associated methyltransferase Cap.
Science 11(363):6423, 2019. DOI:10.1126/science.aav0080 - Saitoh F, Hagiwara H, Wakatsuki S, Araki T.
Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency.
Neuroscience Resarch 139:58-62, 2019. DOI:10.1016/j.neures.2018.08.015 - Ohta K, Aoyama E, Ahmad SAI, Ito N, Anam MB, Kubota S, Takigawa M.
CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.
J Cell Commun Signal. 13(1):113-118, 2019. DOI:10.1007/s12079-018-0487-x - Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M.
Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.
Nautre communications 10 (1):981, 2019. DOI:10.1038/s41467-019-08957-w - Harada, T., Matsumoto, S., Hirota, S., Kimura, H., Fujii, S., Kasahara, Y., Gon, H., Yoshida, T., Itoh, T., Haraguchi, N., Mizushima, T., Noda, T., Eguchi, H., Nojima, S., Morii, E., Fukumoto, T., Obika, S., Kikuchi, A.
Chemically modified antisense oligonucleotide against ARL4C inhibits primary and metastatic liver tumor growth.
Mol. Cancer Ther. 18:602-612, 2019. DOI:10.1158/1535-7163.MCT-18-082 - Orimo, T., I. Sasaki, H. Hemmi, T. Ozasa, Y. Fukuda-Ohta, T. Ohta, M. Morinaka, M. Kitauchi, T. Yamaguchi, Y. Sato, T. Tanaka, K. Hoshino, K. I. Katayama, S. Fukuda, K. Miyake, M. Yamamoto, T. Satoh, K. Furukawa, E. Kuroda, K. J. Ishii, K. Takeda, and T. Kaisho.
Cholera toxin B induces interleukine-1β production from resident peritoneal macrophages through pyrin as well as NLRP3 inflammasome.
Int Immunol. :in press, 2019. DOI:10.1093/intimm/dxz004 - Adhikara IM, *Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata K, Emoto N
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.
Biochem Biophys res Commun 509:89-95, 2019. DOI:10.1016/j.bbrc.2018.12.068 - Kimura H, Yamamoto H, Harada T, Fumoto K, Osugi Y, Sada R, Maehara N, Hikita H, Mori S, Eguchi H, Ikawa M, Takehara T, Kikuchi A.
CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy.
Clin Cancer Res. 25:1936-1947, 2019. DOI:10.1158/1078-0432.CCR-18-2124 - Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.
CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.
Oncogene 14:2580-2594, 2019. DOI:10.1038/s41388-018-0603-7 - Bando Y*, Sakamoto M* (Co-first and corresponding author), Kim S, Ayzenshtat I, Yuste R.
Comparative evaluation of genetically encoded voltage indicators.
Cell Reports 26(3):802-813, 2019. DOI:10.1016/j.celrep.2018.12.088 - Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy.
Pathobiology 86:182-189, 2019. DOI:10.1159/000496027 - Furusho, K., T. Shibata, R. Sato, R. Fukui, Y. Motoi, Y. Zhang, S. I. Saitoh, T. Ichinohe, M. Moriyama, S. Nakamura, and K. Miyake.
Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.
Int Immunol. 31:167-173, 2019. DOI:10.1093/intimm/dxy075 - Naniwa K., Sugimoto Y., Osuka K. and Aonuma H.
Defecation initiates walking in the cricket Gryllus bimaculatus.
J. Insect Physiol. 112:117-122, 2019. DOI:10.1016/j.jinsphys.2018.11.004 - Sashida G, Oshima M, Iwama A.
Deregulated Polycomb functions in myeloproliferative neoplasms.
Int J Hematol 110(2):170-178, 2019. DOI:10.1007/s12185-019-02600-6 - Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.
Oncogene 38:635-655, 2019. DOI:10.1038/s41388-018-0481-z - Serita, T., Miyahara, M., Tanimizu, T., Takahashi, S., Oishi, S., Nagayoshi, T., Tsuji, R., Inoue, H., Uehara, M., Kida, S*.
Dietary magnesium deficiency impairs hippocampus-dependent memories without changes in the spine density and morphology of hippocampal neurons in mice.
Brain Res Bull. 144:149-157, 2019. DOI:10.1016/j.brainresbull.2018.11.019 - Yoshitomi S, Takahashi Y, Imai K, Koshimizu E, Miyatake S, Nakashima M, Saitsu H, Matsumoto N, Kato M, Fujita T, Ishii A, Hirose S, Inoue Y.
Different types of suppression-burst patterns in patients with epilepsy of infancy with migrating focal seizures (EIMFS).
Seizure 65:118-123, 2019. DOI:10.1016/j.seizure.2019.01.009 - Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Mizutani A, et al.
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
Journal of Medicinal Chemistry 62(7):3407-3427, 2019. DOI:10.1021/acs.jmedchem.8b01888 - Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI.
Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
J. Exp. Med. 216:950-965, 2019. DOI:10.1084/jem.20180900 - Takanori NOZAWA, Masayasu OKADA, Manabu NATSUMEDA, Takeyoshi EDA, Hideaki ABE, Yoshihiro TSUKAMOTO, Kouichirou OKAMOTO, Makoto OISHI, Hitoshi TAKAHASHI, Yukihiko FUJII, and Akiyoshi KAKITA
EGFRvIII is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma.
Neurologia medico-chirurgica (Tokyo) 59(3):89-97, 2019. DOI:10.2176/nmc.oa.2018-0078 - Tome S, Sasaki T, Takahashi S, Takei Y.
Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic-polycytidylic acid in inducing fetal loss.
Experimental Animals Volume 68 Issue 4:491-497, 2019. DOI:10.1538/expanim.19-0038 - Noritake A, Nakamura K.
Encoding prediction signals during appetitive and aversive Pavlovian conditioning in the primate lateral hypothalamus.
Journal of neurophysiology 121(2):396-417, 2019. DOI:10.1152/jn.00247.2018 - Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N
Forkhead box protein A1 confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.
J Cell Biochem. 120:2259-2270, 2019. DOI:10.1002/jcb.27551 - Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H.
Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo.
J Physiol Sci. 69(1):65-77, 2019. DOI:10.1007/s12576-018-0618-4 - Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K.
Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.
Addict Biol 25(1):e12723, 2019. DOI:10.1111/adb.12723 - Jun Watanabe, Manabu Natsumeda, Masayasu Okada, Daiki Kobayashi, Yu Kanemaru, Yoshihiro Tsukamoto, Makoto Oishi, Akiyoshi Kakita, Yukihiko Fujii
High detection rate of MYD88 mutations in cerebrospinal fluid from patients with central nervous system lymphomas.
JCO Precision Oncology :in press, 2019. - Kamil M, Shinsato Y, Higa N, Hirano T, Idogawa M, Takajo T, Minami K, Shimokawa M, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K.
High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme.
British Journal of Cancer 120(8):819-826, 2019. DOI:10.1038/s41416-019-0413-x - Htun Y, Nakamura S, Nakao Koyano K, Ohta K, Morimoto A, Wakabayashi T, Sugino M, Fujioka K, Kato I, Kondo S, Yasuda S, Miki T, Ueno M, Kusaka T
Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.
Scientific Reports 9:4088, 2019. DOI:10.1038/s41598-019-40674-8 - Umehara T, Mori R, Mace K, Murase T, Abe Y, Yamamoto T, Ikematsu K
Identification of specific microRNAs in neutrophils of type 2 diabetic mice: overexpression of microRNA-129-2-3p accelerates diabetic wound healing.
Diabetes 68(3):617-630, 2019. DOI:10.1124/jpet.118.253922 - Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
Neuroscience Resarch 139:63-68, 2019. DOI:10.1016/j.neures.2018.08.016 - Yosuke Takei, Saki Tome, Tetsuya Sasaki
Intracellular transport of NMDA receptors and Schizophrenia.
Japanese Journal of Biological Psychiatry :in press, 2019. - *Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, R?os A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y
Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.
The Journal of Neuroscience 39(3):485-502, 2019. DOI:10.1523/JNEUROSCI.1584-18.2018 - Toyokuni S
Iron Addiction with Ferroptosis-resistance in Asbestos-induced Mesothelial Carcinogenesis: Toward the Era of Mesothelioma Prevention.
Free Radical Biology & Medicine 133:206-215, 2019. DOI:10.1016/j.freeradbiomed.2018.10.401 - Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.
Cerebral Cortex 29(9):3738-3751, 2019. DOI:10.1093/cercor/bhy253 - Tsutomu Fukuda, Yusuke Nanjo, Masahiro Fujimoto, Kenyu Yoshida, Yuko Natsui, Fumito Ishibashi, Fumiyasu Okazaki, Hideto To, Masatomo Iwao
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
Bioorganic and Medicinal Chemistry 27 (2):265－277, 2019. DOI:10.1016/j.bmc.2018.11.037 - Miyazaki T, Chowdhury S, Yamashita T, Matsubara T, Yawo H, Yuasa H, Yamanaka A.
Large Timescale Interrogation of Neuronal Function by Fiberless Optogenetics Using Lanthanide Micro-particles. 26(4):1033-1043.e5.
Cell Rep. 26(4):1033-1043.e5., 2019. DOI:10.1016/j.celrep.2019.01.001 - N Shiina
Liquid- and solid-like RNA granules form through specific scaffold proteins and combine into biphasic granules.
J. Biol. Chem. 294:107149 - 107149, 2019. DOI:10.1074/jbc.RA118.005423 - M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T,Oike Y.
Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice.
Circ J. 2019 Jan 25;83(2):368-378, 2019. DOI:10.1253/circj.CJ-18-0925 - Kawahara I, Goto K, Kodama K, Luo Y, Fujiwara-Tani R, Mori T, Miyagawa Y, Tanaka H, Kodama H, Hirayama A, Hosoito N, Taniguchi Y, Miki Y, Kuniyasu H
Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle.
Pathobiology 86:254-262, 2019. DOI:10.1159/000501524 - Iwatani Y, Ogawa, H, Shidara H, Sakura M, Sato T, Hojo MK, Honma A, Tsurui K
Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals.
Advanced Robotics :in press, 2019. - Ueno T, Kaomatsu M
Measuring Nonselective and Selective Autophagy in the Liver.
Methods Mol Biol. 1880, 2019. DOI:10.1007/978-1-4939-8873-0_34 - Keisuke Iida, Yamato Tsushima, Yue Ma, Shadi Sedghi Masoud, Mai Sakuma, Tomomi Yokoyama, Wataru Yoshida, Kazunari Ikebukuro, Kazuo Nagasawa
Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole.
Bioorg. Med. Chem. 27:1742-1746, 2019. DOI:10.1016/j.bmc.2019.02.056 - Sakayori N, Kato S, Sugawara M, Setogawa S, Fukushima H, Ishikawa R, Kida S, Kobayashi K.
Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus.
Mol Brain 12:13, 2019. DOI:10.1186/s13041-019-0431-x - Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H.
mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model.
Pharmacol Biochem Behav.? 176:1-5, 2019. DOI:10.1016/j.pbb.2018.11.003 - Park S, Nayantai E, Komatsu T, Hayashi H, Mori R, Shimokawa I
NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning.
J Gerontol A Biol Sci Med Sci. :in press, 2019. DOI:10.1093/gerona/gly282 - Hosoda, H., *Kida, S
NSP-C contributes to the upregulation of CLOCK/BMAL1-mediated transcription.
Cytotechnology 71:453-460, 2019. DOI:10.1007/s10616-018-0266-9 - Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Yamanaka A, Hikida T, Manabe H, Yamaguchi M.
Opposing roles of dopamine receptor D1- and D2-expressing neurons in the anteromedial olfactory tubercle in acquisition of place preference in mice.
Front Behav Neurosci 13:50, 2019. DOI:10.3389/fnbeh.2019.00050 - Liu Y, Ohshiro T, Sakuragi S, Koizumi K, Mushiake H, Ishizuka T, Yawo H.
Optogenetic study of the response interaction among multi-afferent inputs in the barrel cortex of rats.
Sci Rep. 9(1):3917, 2019. DOI:10.1038/s41598-019-40688-2 - Ghandour K#,?Ohkawa N#,＊, Fung CCA#, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, Nishizono H, Matsuo M, Osanai M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Kitamura T, Fukai T, Inokuchi K＊?(#Equally contributed,?＊Corresponding authors)
Orchestrated ensemble activities constitute a hippocampal memory engram.
Nature Communications 10(1):2637, 2019. DOI:10.1038/s41467-019-10683-2 - Nagase, M., Mikami, K., and Watabe, A.M.# (#責任著者)
Parabrachial-to-amygdala control of aversive learning.
Current Opinion in Behavioral Sciences :in press, 2019. - Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T
Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation deficient mice.
Neuropsychopharmacology Reports 39:61-66, 2019. DOI:10.1002/npr2.12044 - Okada, K., Araki, M., Sakashita, T., Ma, B., Kanda, R., Yanagitani, N., Horiike, A., Koike, S., Oh-Hara, T., Watanabe, K., Tamai, K., Maemondo, M., Nishio, M., Ishikawa, T., Okuno, Y., Fujita, N. and *Katayama, R.
Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance.
EBioMedicine 41:105-119, 2019. DOI:10.1016/j.ebiom.2019.01.019 - Tetsuya Sasaki (Corresponding Author), Yusuke Komatsu, Tetsuo Yamamori (Corresponding Author)
Prefrontal-Enriched SLIT1 Expression in Primate Cortex and its Alteration during Cortical Development.
Japanese Journal of Biological Psychiatry 30(2):in press, 2019. - Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning.
Neurochem Int 126:11-18, 2019. DOI:10.1016/j.neuint.2019.02.011 - Shimizu H., Takeishi S., Nakatsumi H., Nakayama KI.
Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells.
JCI Insight 4:pii-125138, 2019. DOI:10.1172/jci.insight.125138 - Yoshitomi S, Takahashi Y, Yamaguchi T, Oboshi T, Horino A, Ikeda H, Imai K, Okanishi T, Nakashima M, Saitsu H, Matsumoto N, Yoshimoto J, Fujita T, Ishii A, Hirose S, Inoue Y.
Quinidine therapy and therapeutic drug monitoring in four patients with KCNT1 mutations.
Epileptic Disorders 21(1):48-54, 2019. DOI:10.1684/epd.2019.1026 - Koso H, Tsuhako A, Matsubara D, Fujita Y, Watanabe S.
Ras activation in retinal progenitor cells induces tumor formation in the eye.
Exp. Eye Res. 180:39-42, 2019. DOI:10.1016/j.exer.2018.11.025 - Ikuma Kato, Mitsuko Furuya, Masaya Baba, Yoichi Kameda, Masanori Yasuda, Koshiro Nishimoto, Masafumi Oyama, Toshinari Yamasaki, Osamu Ogawa, Hitoshi Niino, Noboru Nakaigawa, Yuta Yano, Kazumasa Sakamoto, Yoji Urata, Kazuya Mikami, Shigetaka Yamasaki, Reiko Tanaka, Toshio Takagi, Tsunenori Kondo, Yoji Nagashima
RBM10‐TFE3 Renal Cell Carcinoma Characterized by Paracentric Inversion with Consistent Closely Split Signals in Break‐apart Fluorescence in situ Hybridization: Study of Ten Cases and a Literature Review.
Histopathology 75(2):254-265, 2019. DOI:10.1111/his.13866 - Imanishi, T., M. Unno, W. Kobayashi, N. Yoneda, S. Matsuda, K. Ikeda, T. Hoshii, A. Hirao, K. Miyake, G. N. Barber, M. Arita, K. J. Ishii, S. Akira, and T. Saito.
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.
Life Sci Alliance 2(1):e201800282, 2019. DOI:10.26508/lsa.201800282 - Kida, S
Reconsolidation/Destabilization, Extinction and Forgetting of Fear Memory as Therapeutic Targets for PTSD.
Psychopharmacology 236:49-57, 2019. DOI:10.1007/s00213-018-5086-2 - Ishifune, C., Tsukumo, SI., Maekawa Y., Hozumi, K., Chung, DH., Motozono, C., Yamasaki, S., Nakano, H., Yasutomo, K.
Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.
PLoS Biol. 17:e3000262, 2019. DOI:10.1371/journal.pbio.3000262 - Hara S, Fukumura S, Ichinose H
Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity.
J Biol Chem 294:1420-1427, 2019. DOI:10.1074/jbc.RA118.005280 - Nakajo H, Ishibashi K, Aoyama K, Kubota S, Hasegawa H, Yamaguchi N, Yamaguchi N
Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling.
Biochem Biophys Res Commun. 511:765-771, 2019. DOI:10.1016/j.bbrc.2019.02.130 - Sugiyama S., Yumimoto K., Inoue I., Nakayama KI.
SCF(Fbxw7) ubiquitylates KLF7 for degradation in a manner dependent on GSK-3?mediated phosphorylation.
Genes Cells 24:354-365, 2019. DOI:10.1111/gtc.12680 - Tatsukawa T, Raveau M, Ogiwara I, Hattori S, Miyamoto H, Mazaki E, Itohara S, Miyakawa T,Montal M, Yamakawa K*
Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity.
Mol Autism 10:15, 2019. DOI:10.1186/s13229-019-0265-5 - Gong B., Kiyotani K., Sakata S., Nagano S., Kumehara S., Baba S., Besse B., Yanagitani N., Friboulet L., Nishio M., Takeuchi K., Kawamoto H., Fujita N., *Katayama R.
Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer.
J Exp Med. 216(4):982-1000, 2019. DOI:10.1084/jem.20180870 - Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F.
Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling.
Biochemical and Biophysical Research Communications 509(3):700-706, 2019. DOI:10.1016/j.bbrc.2018.12.164 - Mitsuhiro Wada, Hiroyuki Suzuki, Mitsuyasu Kato, Hideaki Oikawa, Akira Tsubouchi, Hiroki Oguri
Stereo-Divergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Anti-proliferative Activity.
ChemBioChem 20(10):1273-1281, 2019. DOI:10.1002/cbic.201800815 - Yu Buchin, Yuka Sakemi, Ruriko Hamashima, Yuko Morioka, Daisuke Yamanaka,
Fumihiko Hakuno, Shin-ichiro Takahashi, Kazutoshi Shindo
Structures and biological activities of new carnosic acid- and carnosolrelated compounds generated by heat treatment of rosemary.
Phytochemistry Letters 30:43-48, 2019. DOI:10.1016/j.phytol.2019.01.005 - Tsutomu Fukuda, Yuri Matsuo, Fuyuki Matsuoka, Naoki Yoshioka, Gen Onodera, Masanari Kimura, Fumito Ishibashi, Masatomo Iwao
Synthesis and evaluation of topoisomerase I inhibitors possessing the 5,13-dihydro-6H-benzo[6,7]indolo[3,2-c]quinolin-6-one scaffold.
Heterocycles 99:1032-1052, 2019. DOI:10.3987/COM-18-S(F)70 - Yue Ma, Keisuke Iida, Shogo Sasaki, Takatsugu Hirokawa, Heddi Brahim, Anh Tuan Phan, Kazuo Nagasawa
Synthesis and telomeric G-quadruplex-stabilizing ability of macrocyclic hexaoxazoles bearing three side chains.
Molecules 24:263, 2019. DOI:10.3390/molecules24020263 - Ashida, Y., Yanagita, R. C., Kawanami, Y., Okamura, M., Dan, S. and?Irie, K.
Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin.
Heterocycles 99(2):942-957, 2019. DOI:10.3987/COM-18-S(F)60 - Nishiguchi Y, Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Kishi S, Mori S, Goto K, Yasui W, Sho M*, Kuniyasu H
Targeting claudin-4 enhances CDDP-chemosensitivity of gastric cancer.
Oncotarget 10:2189-2202, 2019. DOI:10.18632/oncotarget.26758 - Mito M.,Kadota M., Nakagawa S.*, Iwasaki S.*
tChIP-Seq: cell-type-specific Eepigenome profiling.
J. Vis. Exp 143:e58298, 2019. DOI:10.3791/58298 - Masaya Baba, Mitsuko Furuya, Takanobu Motoshima, Martin Lang, Shintaro Funasaki, Wenjuan Ma, Hong-Wei Sun, Hisashi Hasumi, Ying Huang, Ikuma Kato, Tsuyoshi Kadomatsu, Yorifumi Satou, Nicole Morris, Baktiar O. Karim, Lilia Ileva, Joseph D. Kalen, Luh Ade Wilan Krisna, Kimi Araki et al.
TFE3 Xp11.2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease.
Molecular Cancer Research 17:1613-1626, 2019. DOI:10.1158/1541-7786.MCR-18-1235 - Iwasaki S.*, Iwasaki W., Takahashi M., Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T.*, and Ingolia NT.*
The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA.
Mol. Cell 73:1-10, 2019. DOI:10.1016/j.molcel.2018.11.026 - Liang L, Teh D, Dinh ND, Chen W, Chen Q, Wu Y, Chowdhury S, Yamanaka A, Sum TC, Chen CH, Thakor N, All A, Liu X
Upconversion Amplification through Dielectric Superlensing Modulation.
Nat Commun 10:1391, 2019. DOI:10.1038/s41467-019-09345-0 - 平石哲也、棗田学、岡田正康、大石誠、藤井幸彦
悪性髄膜腫における個別化医療の可能性.
Precision Medicine 2(1):54-58, 2019. - Ito N., Mohammad B., A., Shah A., I., A., and Ohta K.
Transdifferentiation of human somatic cells by ribosome.
Development Growth & Differentiation 60:241-247, 2018. DOI:10.1111/dgd.12538 - 山本一男
"サイズ"で斬る生物学への誘い.
実験医学 36(13):2168-2173, 2018. - Mizotani Y, Suzuki M, Hotta K, Watanabe H, Shiba K, Inaba K, Tashiro E, Oka K and Imoto M.
14-3-3εa directs the pulsatile transport of basal factors towards the apical domain for lumen growth in tubulogenesis.
Proc. Natl. Acad. Sci. USA 115:E8873-E8881, 2018. DOI:10.1073/pnas.1808756115 - Gong, B., Oh-Hara, T., Fujita, N. and *Katayama, R.
3D culture system containing gellan gum restores oncogene dependence in ROS1 rearrangements non-small cell lung cancer.
Biochem. Biophys. Res. Commun., 501:527-533, 2018. DOI:10.1016/j.bbrc.2018.05.031 - Horai T, Hishimoto A, Otsuka I, So T, Mouri K, Shimmyo N, Boku S, Okishio N, Sora I.
A Cross-Sectional Study Exploring Useful Indicators for Low Bone Mineral Density in Male Alcoholic Patients.
Neuropsychiatr Dis Treat 14:663-669, 2018. DOI:10.2147/NDT.S153360 - Kosuke Ishikawa, Yuta Kobayashi, Yutaro wakabayashi, Shinya Watanabe and Kentaro Semba
A highly sensitive trap vector system for isolating reporter cells and identification of responsive genes.
Biology Methods and Protocols 3:bpy003, 2018. DOI:10.1093/biomethods/bpy003 - Nakajima C, Kamimoto K, Miyajima K, Matsumoto M, Okazaki Y, Kobayashi-Hattori K, Shimizu M, Yamane T, Oishi Y, Iwatsuki K.
A new method for identifying mouse pancreatic ducts.
Tissue Eng. ?24(8):480?485, 2018. DOI:10.1089/ten.tec.2018.0127 - Kamijo Y, Kawahara K, Yoshinaga T, Kurata H, Arima K, Furukawa T.
A novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analyses.
Oncoscience. 5:88-98, 2018. DOI:10.18632/oncoscience.411 - Okumura A, Maruyama K, Shibata M, Kurahashi H, Ishii A, Numoto S, Hirose S, Kawai T, Iso M, Kataoka S, Okuno Y, Muramatsu H, Kojima S.
A patient with a GNAO1 mutation with decreased spontaneous movements, hypotonia, and dystonic features.
Brain & Development 40(10):926-930, 2018. DOI:10.1016/j.braindev.2018.06.005 - Zhang Y, Nakano D, Guan Y, Hitomi H, Masaki T, Kobara H, Sugaya Y, Nishiyama A.
A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice.
Kidney Int. 94(3):524-535., 2018. DOI:10.1016/j.kint.2018.05.002 - Yabe R, Tsuji S, Mochida S, Ikehara T, Usui T, Ohama T*, Sato K
A stable association with PME‐1 may be dispensable for PP2A demethylation ? implications for the detection of PP2A methylation and immunoprecipitation.
FEBS Open Bio 8(9):1486-1496, 2018. DOI:10.1002/2211-5463.12485 - Toratani, M., Konno, M., Asai, A., Koseki, J., Kawamoto, K., Tamari, K., Li, Z., Sakai, D., Kudo, T., Satoh, T., Sato, K., Motooka, D., Okuzaki, D., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
Ability of a convolutional neural network to differentiate between mouse and human cell lines and their radioresistant clones using microscopic images.
Cancer Res 78, 2018. DOI:10.1158/0008-5472 - Takahashi Y, Hamasaki M, Aoki M, Koga K, Koshikawa N, Miyamoto S, Nabeshima K.
Activated EphA2 processing by MT1-MMP is involved in malignant transformation of ovarian tumours in vivo.
Anticancer Res 38:4257-4266, 2018. DOI:10.21873/anticanres.12722 - Ichimura Y, Komatsu M.
Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.
Front Oncol. 8, 2018. DOI:10.3389/fonc.2018.00210 - Moriya S, Yamashita A, Kawashima S, Nishi R, Yamanaka A, Kuwaki T.
Acute aversive stimuli rapidly increase the activity of ventral tegmental area dopamine neurons in awake mice.
Neuroscience 386:16-23, 2018. DOI:10.1016/j.neuroscience.2018.06.027 - Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, Endo M, Zhu S, Fan H, Horiguchi H, Morinaga J, Terada K, Yoshizawa T, Yamagata K, Oike Y
Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice.
J Biol Chem 293:1596-1609, 2018. DOI:10.1074/jbc.M117.814996 - Ichinose H, Inoue KI, Arakawa S, Watanabe Y, Kurosaki H, Koshiba S, Hustad E, Takada M, Aasly JO
Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease.
J Neural Transm 125:45-52, 2018. DOI:10.1007/s00702-017-1784-x - Tsurumaru, H., Ito, N., Mori, K., Wakai, S., Uchiyama, T., Iino, T., Hosoyama, A., Ataku, H., Nishijima, K., Mise, M., Shimizu, A., Harada, T., Horikawa, H., Ichikawa, N., Sekigawa, T., Jinno, K., Tanikawa, S., Yamazaki, J., Sasaki, K., Yamazaki, S., Fujita, N., and Harayama, S.,
An extracellular [NiFe] hydrogenase mediating iron corrosion is encoded in a genetically unstable genomic island in Methanococcus maripaludis.
Scientific Reports 8 8:15149, 2018. DOI:10.1038/s41598-018-33541-5 - M. Ishido*
An Overview of Development of Quantitative Neurotoxicity Testing In vitro.
J. Applied Life Sci. Intl. 19:2394-1103, 2018. DOI:10.9734/JALSI/2018/45377 - Fink J, Jackney A, Matsumoto M, Maekawa T, Nakazato K, Horie S.
Anabolic-androgenic steroids: procurement and administration practices of doping athletes.
Physician. Sportsmedicine 2 47(1):10-14., 2018. DOI:10.1080/00913847.2018.1526626 - Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrian Marchand, Fernaldo Richtia Winnerdy, Valerie Gabelica, Anh Tuan Phan, Masato Katahira & Kazuo Nagasawa
Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound.
ChemBioChem 19:2268-2272, 2018. DOI:10.1002/cbic.201800425 - Shimizu Y, Tamada S, Kato M, Hirayama Y, Takeyama Y, Iguchi T, Sadar MD, Nakatani T.
Androgen Receptor Splice Variant 7 Drives the Growth of Castration Resistant Prostate Cancer without Being Involved in the Efficacy of Taxane Chemotherapy.
J Clin Med 7(11):E444, 2018. DOI:10.3390/jcm7110444 - Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Nishiguchi Y, Kishi S, Mori S, Goto K, Kondoh M, Kuniyasu H
Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer.
Oncotarget 9(100):37367-37378, 2018. DOI:10.18632/oncotarget.26427 - Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki E, Takeda A, Le HPN, Hayashi H, Hiasa M, Moriyama Y, Ikenaka K, Tanaka KF, Koizumi S
Anti-Depressant Fluoxetine Reveals its Thrapeutic Effect Via Astrocytes.
E BioMedicine 32:72-83, 2018. DOI:10.1016/j.ebiom.2018.05.036 - Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, R?os A, Kawabata M, Kimura M, Sakai Y, *Isomura Y
Area-specific modulation of functional cortical activity during block-based and trial-based proactive inhibition.
Neuroscience 388:297-316, 2018. DOI:10.1016/j.neuroscience.2018.07.039 - Saika M, Inoue D, Nagase R, Sato N, Tsuchiya A, Yabushita T, Kitamura T, Goyama S.
ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFb pathway genes through histone deacetylation.
Sci. Rep. 8(1):15873, 2018. DOI:10.1038/s41598-018-33881-2 - Hisashi Hasumi, Mitsuko Furuya, Kenji Tatsuno, Shogo Yamamoto, Masaya Baba, Yukiko Hasumi, Yasuhiro Isono, Kae Suzuki, Ryosuke Jikuya, Shinji Otake, Kentaro Muraoka, Kimito Osaka, Narihiko Hayashi, Kazuhide Makiyama, Yasuhide Miyoshi, Keiichi Kondo, Noboru Nakaigawa, Takashi Kawahara, Koji Izumi, Junichi Teranishi, Yasushi Yumura, Hiroji Uemura, Yoji Nagashima, Adam R Metwalli, Laura S Schmidt, Hiroyuki Aburatani, W Marston Linehan, Masahiro Yao
BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes.
Human molecular genetics 27(15):2712-2724, 2018. DOI:10.1093/hmg/ddy181 - Michael S Nahorski, Sateesh Maddirevula, Ryosuke Ishimura, Saud Alsahli, Angela Brady, Ana?s Begemann, Tsunehiro Mizushima, Francisco J. Guzm?n-Vega, Miki Obata, Yoshinobu Ichimura, Hessa S Alsaif, Shams Anazi, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Dorota Monies, Mohamed Abouelhoda, Brian F Meyer, Majid Alfadhel, Wafa Eyaid, Markus Zweier Katharina Steindl, Anita Rauch, Stefan T. Arold, *C Geoffrey Woods, *Masaaki Komatsu, *Fowzan S Alkuraya.
Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.
Brain 141:1934-1945, 2018. DOI:10.1093/brain/awy135 - Mutoh, H., M. Kato, T. Akita, T. Shibata, H. Wakamoto, H. Ikeda, H. Kitaura, K. Aoto, M. Nakashima, T. Wang, C. Ohba, S. Miyatake, N. Miyake, A. Kakita, K. Miyake, A. Fukuda, N. Matsumoto, and H. Saitsu.?
Biallelic Variants in CNPY3, Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy.
Am J Hum Genet 102(2):321-329, 2018. DOI:10.1016/j.ajhg.2018.01.004 - Kondo T, Saito R, Otaka M, Yoshino-Saito K, Yamanaka A, Yamamori T, Watakabe A, Mizukami H, Schnitzer MJ, Tanaka KF, Ushiba J, Okano H.
Calcium transient dynamics of neural ensembles in the primary motor cortex of naturally behaving monkeys.
Cell Rep 24(8):2191-2195, 2018. DOI:10.1016/j.celrep.2018.07.057 - Tatsunori Nishimura, Asuka Nakata, Xiaoxi Chen, Kurumi Nishi, Makiko Meguro-Horike, Soichiro Sasaki, Kenji Kita, Shin-ichi Horike, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Takahiko Murayama, Susumu Kohno, Chiaki Takahashi, Naofumi Mukaida, Seiji Yano, Tomoyoshi Soga, Arinobu Tojo, Noriko Gotoh
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Oncogene 38(14):2464-2481, 2018. DOI:10.1038/s41388-018-0589-1 - Umeda M, Koga T, Ichinose K, Igawa T, Sato T, Takatani A, Shimizu T, Fukui S, Nishino A, Horai Y, Hirai Y, Kawashiri S.-Y, Iwamoto N, Aramaki T, Tamai M, Nakamura H, Yamamoto K, Abiru N, Origuchi T, Ueki Y and Kawakami A
CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus.
Clinical Immunology 187:50-57, 2018. DOI:10.1016/j.clim.2017.10.004 - Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration.
Neurochem Int 119:190-198, 2018. DOI:10.1016/j.neuint.2018.01.003 - Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H.
Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
Scientific Reports 8:e14827, 2018. DOI:10.1038/s41598-018-33139-x - Morrison, S.F., Nakamura, K.
Central mechanisms for thermoregulation.
Annual Review of Physiology 81:285-308, 2018. DOI:10.1146/annurev-physiol-020518-114546 - Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR.
Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.
Cell Reports 24:2196-2210, 2018. DOI:10.1016/j.celrep.2018.07.056 - Ryo Tanifuji, Kento Koketsu, Michiko Takakura, Ryutaro Asano, Atsushi Minami, Hideaki Oikawa, Hiroki Oguri
Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3.
J. Am. Chem. Soc. 140(34):10705?10709, 2018. DOI:10.1021/jacs.8b07161 - Tomoaki Taniguchi, Akira Tsubouchi, Yuki Imai, Junpei Yuasa, Hiroki Oguri
Chiroptical Inversion of Europium(III) Complexes by Changing a Remote Stereogenic Center of a C2-symmetric Bispyrrolidinoindoline Manifold.
J. Org. Chem. 83(24):15284?15296, 2018. DOI:10.1021/acs.joc.8b02550 - Fukui, R., C. Yamamoto, F. Matsumoto, M. Onji, T. Shibata, Y. Murakami, A. Kanno, T. Hayashi, N. Tanimura, N. Yoshida, and K. Miyake.
Cleavage?of?Toll-Like Receptor 9?Ectodomain?Is?Required?for?In Vivo?Responses to Single Strand DNA.
Front Immunol 9:1491, 2018. DOI:10.3389/fimmu.2018.01491 - Noguchi K, Konno M, Eguchi H, Kawamoto K, Mukai R, Nishida N, Koseki J, Wada H, Akita H, Satoh T, Marubashi S, Nagano H, Doki Y, Mori M, Ishii H.
c-Met affects gemcitabine resistance during carcinogenesis in a mouse model of pancreatic cancer.
Oncol Lett 16(2):1892-1898, 2018. DOI:10.3892/ol.2018.8793 - Sato, R., A. Kato, T. Chimura, S. I. Saitoh, T. Shibata, Y. Murakami, R. Fukui, K. Liu, Y. Zhang, J. Arii, G. H. Sun-Wada, Y. Wada, T. Ikenoue, G. N. Barber, T. Manabe, Y. Kawaguchi, and K. Miyake.
Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.
Nat Immunol 19(10):1071-1082, 2018. DOI:10.1038/s41590-018-0203-2 - Aonuma H., Totani Y., Sakakibara M., Lukowiak K. and Ito E.
Comparison of brain monoamine content in three populations of Lymnaea that correlates with taste-aversive learning ability.
Biophys. Physicobiol. 15:129-135, 2018. DOI:10.2142/biophysico.15.0_129 - Ida-Yonemochi H, Morita W, Sugiura N, Kawakami R, Morioka Y, Takeuchi Y, Sato T, Shibata S, Watanabe H, Imamura T, Igarashi M, Ohshima H, Takeuchi K
Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.
Sci Rep 8:17134-, 2018. DOI:10.1038/s41598-018-35412-5 - Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T
Deficiency of AMPA receptor-palmitoylation aggravates seizure susceptibility.
Journal of Neuroscience 38:10220-10235, 2018. DOI:10.1523/JNEUROSCI.1590-18.2018 - Zhou L, Hossain MI, Yamazaki M, Abe M, Natsume R, Konno K, Kageyama S, Komatsu M, Watanabe M, Sakimura K, Takebayashi H.
Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype.
J Neurochem 147:557-572, 2018. DOI:10.1111/jnc.14591 - Karnakar Reddy Bonepally, Takahisa Hiruma, Haruki Mizoguchi, Kyohei Ochiai, Shun Suzuki, Hideaki Oikawa, Aki Ishiyama, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Omura, Hiroki Oguri
Design and De Novo Synthesis of 6-Aza-artemisinins.
Org. Lett. 20(15):4667?4671, 2018. DOI:10.1021/acs.orglett.8b01987 - Nana Tsuchiya, Yunosuke Ryu, Takahiro Muraoka, Hiroki Oguri
Design of C2-symmetric alkaloidal chiral amphiphiles and configurational effects on self-assembly.
Org. Biomol. Chem. 16:9305-9313, 2018. DOI:10.1039/C8OB02287A - Yue Ma, Yamato Tsushima, Mai Sakuma, Shogo Sasaki, Keisuke Iida, Sachiko Okabe, Hiroyuki Seimiya, Takatsugu Hirokawa, Kazuo Nagasawa
Development of G-quadruplex ligand for selective induction of parallel-type topology.
Org. Biomol. Chem. 16:7375-7382, 2018. DOI:10.1039/C8OB01702F - Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, and Komuro I.
Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury.
JACC:Basic to Translational Science 12;3(5):639-653, 2018. DOI:10.1016/j.jacbts.2018.07.005 - Brew N, Nakamura S, Hale, N. Azhan, A., Davies, G. I.
Nitsos, I., Miller, S. L., Walker, D. W., Wong, F. Y.
Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia.
Pediatr Res 84(3):442-450, 2018. DOI:10.1038/s41390-018-0045-5 - Nagai, N., Ohguchi, H., Nakaki, R., Matsumura, Y., Kanki, Y., Sakai, J., Aburatani, H., and Minami, T
Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.
PLoS Genet. 2018 14:e1007826., 2018. - Kikuchihara S, Sugio S, Tanaka KF, Watanabe T, Kano M, Yamazaki Y, Watanabe M, Ikenaka K.
Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice.
J Neurochem 147(3):344-360, 2018. DOI:10.1111/jnc.14486 - Takayama Y, Ando T, Ichikawa J, Haro H
Effect of Thrombin-Induced MCP-1 and MMP-3 Production Via PAR1 Expression in Murine Intervertebral Discs.
Sci Rep 8(1):11320, 2018. DOI:10.1038/s41598-018-29669-z - Ahmat Amin MKB, Shimizu A, Zankov DP, Sato A, Kurita S, Ito M, Maeda T, Yoshida T, Sakaue T, Higashiyama S, Kawauchi A, Ogita H.
Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1.
Oncogene 37:5416-5434, 2018. DOI:10.1038/s41388-018-0286-0 - Tanaka Y, Higurashi N, Shirasu N, Yasunaga S, Moreira KM, Okano H, Hirose S.
Establishment of a human induced stem cell line (FUi002-A) from Dravet syndrome patient carrying heterozygous R1525X mutation in SCN1A gene.
Stem Cell Research 31:11-15, 2018. DOI:10.1016/j.scr.2018.06.008 - Y. Yamashita, Y. Saito, S. Kikkawa, Y. Mutoh, S. Hosoya, I. Azumaya, S. Saito
Evaluation of the Steric Bulk of Substituents Utilizing the Shuttling Behavior of [2]Rotaxanes with N-Arylpyrrole Moieties.
EUR J ORG CHEM 2019:3412-3420, 2018. DOI:10.1002/ejoc.201801476 - Nakashima C, Yamamoto K, Fujiwara-Tani R, Luo Y, Matsushima S, Fujii K, Ohmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H
Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.
Cancer Sci 109(6):2036-2045, 2018. DOI:10.1111/cas.13594 - Aoyama K, Oshima M, Koide S, Suzuki E, Mochizuki-Kashio M, Kato Y, Tara S, Shinoda D, Hiura N, Nakajima-Takagi Y, Sashida G, Iwama A.
Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.
iScience 9:161-174, 2018. DOI:10.1016/j.isci.2018.10.008 - Wang C, Oshima M, Sato D, Matsui H, Kubota S, Aoyama K, Nakajima-Takagi Y, Koide S, Matsubayashi J, Mochizuki-Kashio M, Nakano-Yokomizo T, Bai J, Nagao T, Kanai A, Iwama A, Sashida G.
Ezh2 loss propagates hypermethylation at T-cell differentiation-regulating genes to promote leukemic transformation.
J Clin Invest 128(9):3872-86, 2018. DOI:10.1172/JCI94645 - Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
Jounal of Clinical Investigation 128(12):5603-5619, 2018. DOI:10.1172/JCI121679 - Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A.
FEAT enhances INSL3 expression in testicular Leydig cells.
Genes to cells 23:952-962, 2018. DOI:10.1111/gtc.12644 - Masaya Baba, Mitsuhiro Endoh, Wenjuan Ma, Hirofumi Toyama, Akiyoshi Hirayama, Keizo Nishikawa, Keiyo Takubo, Hiroyuki Hano, Hisashi Hasumi, Terumasa Umemoto, Michihiro Hashimoto, Nobuko Irie, Chiharu Esumi, Miho Kataoka, Naomi Nakagata, Tomoyoshi Soga, Masahiro Yao, Tomomi Kamba, Takashi Minami, Masaru Ishii, Toshio Suda
Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation.
Journal of Bone and Mineral Research 33(10):1785-1798, 2018. DOI:10.1002/jbmr.3477 - Sulistomo HW, Nemoto T, Yanagita T, Takeya R.
Formin homology 2 domain-containing 3 (Fhod3) controls neural plate morphogenesis in mouse cranial neurulation by regulating multidirectional apical c ….
J Biol Chem 294:2924-2934, 2018. DOI:10.1074/jbc.RA118.005471 - Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women: Chiba bone survey.
Endocr J 65(2):193-202, 2018. DOI:10.1507/endocrj.EJ17-0331 - Kaneko R, Kakinuma T, Sato S, Jinno-Oue A.
Freezing sperm in short straws reduces storage space and allows transport in dry ice.
J Reprod Dev. 64(6):541-545, 2018. DOI:10.1262/jrd.2018-100 - Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Ichikawa J, Osada M, Satoh K, Ozaki Y, Suzuki-Inoue K.
Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis.
J Thromb Haemost 16(5):960-972, 2018. DOI:10.1111/jth.13987 - Hayashida T, Saito Y, Ishii A, Hirose S, Hiraiwa R, Maegaki Y, Ohno K.
Further characterization of CAPOS/CAOS syndrome with the Glu818Lys mutation in the ATP1A3 gene: A case report.
Brain & Development 40(7):576-581, 2018. DOI:10.1016/j.braindev.2018.03.004 - Yokoshima Y, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Kato R, Hozumi J, Abe H, Azuma K, Tsuchida R, Yamada Y, Japanese TR-Cancer Pain Research Group.
Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain: An exploratory study.
Neuropsychopharmacology Report 38:175-181, 2018. DOI:10.1002/npr2.12030 - Kuriyama Y, Hattori M, Mitsui T, Nakano H, Oikawa D, Tokunaga F, Ishikawa O, Shimizu A.
Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency.
Journal of Dermatology 45(5):e108-e109, 2018. DOI:10.1111/1346-8138 - Shiori Miura, Yoshitaka Maeda, Jun Miyamoto, Ena Nakatsukasa, Nobuyoshi Fujisawa, Miki Miwa, Katsuki Nakamura, Kenji Sakimura and Toshikuni Sasaoka
Generation of functional oocytes of common marmoset by xeno-transplantation of ovarian tissue.
Proceedings of International Symposium on Animal Production and Conservation for Sustainable Development 2018 :31-33, 2018. - Oikawa D, Shiota M, Wanibuchi H, Tokunaga F.
Generation of rat monoclonal antibodies against a deubiquitinase, ovarian tumor domain-containing protein 1.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 37(4):180-184, 2018. DOI:10.1089/mab.2018.0023 - Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
Generation of rat monoclonal antibodies specific for DZIP3.
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 37(3):153-157, 2018. DOI:10.1089/mab.2018.0005 - Orr? C*, Szydlowska M*, Taguchi K*, Zavattari P, Perra A, Yamamoto M, Columbano A
Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis.
J Hepatol 69:635-643, 2018. DOI:10.1016/j.jhep.2018.05.010 - Ito-Ishida A, Yamalanchili HK, Shao Y, Baker SA, Heckman LD, Lavery LA, Kim JY, Lombardi LM, Sun Y, Liu Z, Zoghbi HY.
Genome-wide distribution of linker histone H1.0 is independent of MeCP2.
Nature Neuroscience 21(6):794-798, 2018. DOI:10.1038/s41593-018-0155-8 - Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Miyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T.
Glucagonoma With Necrolytic Migratory Erythema: Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.
J Clin Endocrinol Metab 103(7):2417-2423, 2018. DOI:10.1210/jc.2017-02646 - Nishihara S
Glycans in stem cell regulation: from Drosophila tissue stem cells to mammalian pluripotent stem cells.
FEBS Lett. 592(23):3773-3790, 2018. DOI:10.1002/1873-3468.1316 - Maruzuru, Y., T. Ichinohe, R. Sato, K. Miyake, T. Okano, T. Suzuki, T. Koshiba, N. Koyanagi, S. Tsuda, M. Watanabe, J. Arii, A. Kato, and Y. Kawaguchi.
Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.
Cell Host Microbe 23(2):254-265, 2018. DOI:10.1016/j.chom.2017.12.014 - Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System.
SLAS Discovery 23(10):1018-1029, 2018. DOI:10.1177/2472555218793066 - Yamauchi Y., Itoh S. et al.
HipOP mesenchymal population has high potential for repairing injured peripheral nerves.
J. Cell Biochem. 119(6):4836-4844, 2018. DOI:10.1002/jcb.26684 - Nakamura, K., Nakamura, Y.
Hunger and satiety signaling: Modeling two hypothalamomedullary pathways for energy homeostasis.
BioEssays 40:1700252, 2018. DOI:10.1002/bies.201700252 - Mori R, Tanaka K, Shimokawa I
Identification and functional analysis of inflammation-related miRNAs in skin wound repair.
Dev Growth Differ 60(6):306-315, 2018. DOI:10.1111/dgd.12542 - Watanabe T., Ugajin A. and Aonuma H.
Immediate-early promoter-driven transgenic reporter system for neuroethological researches in a hemimetabolous insect.
eNeuro 5:e0016-18, 2018. DOI:10.1523/ENEURO.0061-18.2018 - Shadi Sedghi Masoud, Kazuo Nagasawa
i-Motif-binding ligand and their effects on the structure and biological functions of i-motif.
Chem. Pharm. Bull. 66:1091-1103, 2018. DOI:10.1248/cpb.c18-00720 - Takeuchi E, Ito-Ishida A, Yuzaki M, Yanagihara D.
Improvement of cerebellar ataxic gait by injecting Cbln1 into the cerebellum of cbln1-null mice.
Sci. Rep. 8(1):6184, 2018. DOI:10.1038/s41598-018-24490-0 - Hirofumi Shibata, Shingo Komura, Yosuke Yamada, Nao Sankoda, Akito Tanaka, Tomoyo Ukai, Mio Kabata, Satoko Sakurai, Bunya Kuze, Knut Woltjen, Hironori Haga, Yatsuji Ito,
Yoshiya Kawaguchi, Takuya Yamamoto, Yasuhiro Yamada
In vivo reprogramming drives Kras-induced cancer development.
Nature Communications 9:2081, 2018. DOI:10.1038/s41467-018-04449-5 - Ikoma Y, Kusumoto-Yoshida I, Yamanaka A, Ootsuka Y, Kuwaki T.
Inactivation of serotonergic neurons in the rostral medullary raphe attenuates stress-induced tachypnea and tachycardia in mice.
Front Physiol 9:832, 2018. DOI:10.3389/fphys.2018.00832 - Okazaki S, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Kinoshita M, Inoue E, Ohmori T, Someya T, Sora I.
Increased Serum Levels and Promoter Polymorphisms of Macrophage Migration Inhibitory Factor in Schizophrenia.
Prog Neuropsychopharmacol Biol Psychiatry 83:33-41, 2018. DOI:10.1016/j.pnpbp.2018.01.001 - Okazaki S ; Hishimoto A ; Otsuka I ; Watanabe Y ; Numata S ; Boku S ; Shimmyo N ; Kinoshita M ; Inoue M ; Ohmori T ; Someya T ; Sora I
Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia.
Prog Neuropsychopharmacol Biol Psychiatry 83:33-41, 2018. DOI:10.1016/j.pnpbp.2018.01.001 - Takizawa H*, Hayashi Y
Inflammation and early hematopoiesis.
Rinsho Ketsueki 59:1955-1961, 2018. DOI:10.11406/rinketsu.59.1955 - Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki SI, Wakamatsu K, Tokunaga F, Shimizu A.
In-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.
Journal of Dermatological Science 91(1):35-42, 2018. DOI:10.1016/j.jdermsci.2018.03.012 - Miyagawa Y, Mori T, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Ohmori H, Kawahara I, Kuniyasu H
Intake of medium-chain fatty acids induces oxidative stress and to atrophy the myocardium.
Lipids in Health and Disease 17:258, 2018. DOI:10.1186/s12944-018-0908-0 - Matsuyama S, Kage Y, Fujimoto N, Ushijima T, Tsuruda T, Kitamura K, Shiose A, Asada Y, Sumimoto H, Takeya R.
Interaction between cardiac myosin-binding protein C and formin Fhod3.
Proc Natl Acad Sci U S A. 115(19):E4386-E4395, 2018. DOI:10.1073/pnas.1716498115 - Shimamura M, Yamamoto K, Kurashige T, Nagayama Y
Intracellular redox status controls spherogenicity, an?in vitro?cancer stem cell marker, in thyroid cancer cell lines.
Experimental Cell research 370(2):699-707, 2018. DOI:10.1016/j.yexcr.2018.07.036 - Hirata T ; Hishimoto A ; Otsuka I ; Okazaki S ; Boku S ; Kimura A ; Horai T ; Sora I
Investigation of chromosome Y loss in men with schizophrenia.
Neuropsychiatr Dis Treat 14:2115-2122, 2018. DOI:10.2147/NDT.S172886 - Takeuchi Y., Kito A. et al.
Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling.
Exp. Cell Res. 371(2):417-425, 2018. DOI:10.1016/j.yexcr.2018.09.002 - Sasaki K ; Hall FS ; Uhl GR ; Sora I
Larger Numbers of Glial and Neuronal Cells in the Periaqueductal Gray Matter of μ-Opioid Receptor Knockout Mice.
Front Psychiatry 9:441, 2018. DOI:10.3389/fpsyt.2018.00441 - Zhang Y ; Hishimoto A ; Otsuka I ; Watanabe Y ; Numata S ; Yamamori H ; Boku S ; Horai T ; Someya T ; Ohmori T ; Hashimoto R ; Sora I
Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population.
J Psychiatr Res 103:161-166, 2018. DOI:10.1016/j.jpsychires - Kimura A, Hishimoto A, Otsuka I, Okazaki S, Boku S, Horai T, Izumi T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
Loss of Chromosome Y in Blood, but Not in Brain, of Suicide Completers.
PLoS One 13(1):e0190667, 2018. DOI:10.1371/journal.pone.0190667 - Tsukahara, R., Yamamoto, S., Yoshikawa, K., Gotoh, M., Tsukahara, T., Neyama, H., Ishii, S., Akahoshi, N., Yanagida, K., Sumida, H., Araki, M., Araki, K., Yamamura, K. I., Murakami-Murofushi, K., Ueda, H.
LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.
J. Pharmacol.Sci. 136:93-96, 2018. DOI:10.1016/j.jphs.2018.01.001 - Hideaki ABE, Manabu NATSUMEDA, Yu KANEMARU, Jun WATANABE, Yoshihiro TSUKAMOTO, Masayasu OKADA, Junichi YOSHIMURA, Makoto OISHI, and Yukihiko FUJII
MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas.
Neurol Med Chir (Tokyo) 58:290-295, 2018. DOI:10.2176/nmc.ra.2018-0044 - Takeda A, Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J, Koizumi S.
Microglia mediate non-cell autonomous cell death of retinal ganglion cells.
GLIA 66:2366-2384, 2018. DOI:10.1002/glia.23475 - Kokuda R, Watanabe R, Okuzaki D, Akamatsu H, Oneyama C.
MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression.
Genes Cells 23(8):688-701, 2018. DOI:10.1111/gtc.12610 - Yamaki N ; Otsuka I ; Numata S ; Yanagi M ; Mouri K ; Okazaki S ; Boku S ; Horai T ; Ohmori T ; Shirakawa O ; Sora I ; Hishimoto A
Mitochondrial DNA copy number of peripheral blood in bipolar disorder: The present study and a meta-analysis.
Psychiatry Res 269:115-117, 2018. DOI:10.1016/j.psychres - Takaoka, Y., Konno, M., Koseki, J., Colvin, H., Asai, A., Tamari, K., Satoh, T., Mori, M., Doki, Y., Ogawa, K., Ishii, H.
Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance.
Cancer Sci. 110:1331-1339, 2018. DOI:10.1111/cas.13980 - Fink J, Jackney A, Matsumoto M, Maekawa T, Nkazato K, Horie S.
Mobility and biomechanical functions in the aging male: testosterone and the Locomotive Syndrome.
Aging Male 29:1-8, 2018. DOI:10.1080/13685538.2018.1504914 - Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, *Isomura Y, *Kimura M
Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways.
Neuron 99(6):1302-1314, 2018. DOI:10.1016/j.neuron.2018.08.002 - Kano M, Watanabe T, Uesaka N, Watanabe M.
Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum.
Cerebellum. 17(6):722?734, 2018. DOI:10.1007/s12311-018-0964-z - Someya, M. and Ogawa, H.
Multisensory enhancement of burst activity in an insect auditory neuron.
J Neurophysiol. 120:139-148., 2018. DOI:10.1152/jn.00798.2017 - Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T.
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.
Nature Commun. 9(1):2733, 2018. DOI:10.1038/s41467-018-05085-9 - Hirotaka Watanabe, et al.
Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition With the Neighboring Normal Epithelial Cells.
Cell Reports 23:3721-3729, 2018. DOI:10.1016/j.celrep.2018.05.081 - Tamiya Y ; Ouchi A ; Chen R ; Miyazawa S ; Akimoto Y ; Kaneda Y ; Sora I
Neurocognitive Impairments Are More Severe in the Binge-Eating/Purging Anorexia Nervosa Subtype Than in the Restricting Subtype.
Front Psychiatry 138:9, 2018. DOI:10.3389/fpsyt.2018.00138 - Matsui S, Sasaki T, Kohno D, Yaku K, Inutsuka A, Yokota-Hashimoto H, Kikuchi O, Suga T, Kobayashi M, Yamanaka A, Harada A, Nakagawa T, Onaka T, Kitamura T.
Neuronal sirt1 regulates macronutrient-based diet selection through fgf21 and oxytocin signalling in mice.
Nat Commun 9(1):4604, 2018. DOI:10.1038/s41467-018-07033-z - Sasahira T, Nishiguchi Y, Kurihara-Shimomura M, Nakashima C, Kuniyasu H, Kirita T.
NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma.
J Cancer Res Clin Oncol 144(5):875-882, 2018. DOI:10.1007/s00432-018-2612-x - Tel-Karthaus N, Kers-Rebel ED, Looman MW, Ichinose H, de Vries CJ, Ansems M
Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function.
Front Immunol 9:1797, 2018. DOI:10.3389/fimmu.2018.01797. - Nakatsumi H., Oka T., Higa T., Shirane M., Nakayama KI.
Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1.
Genes Cells 23:599-605, 2018. DOI:10.1111/gtc.12597 - Thannickal TC, John J, Shan L, Swaab DF, Wu MF, Ramanathan L, McGregor R, Chew KT, Cornford M, Yamanaka A, Inutsuka A, Fronczek R, Lammers GJ, Worley PF, Siegel JM.
Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy.
Sci Transl Med 10, 2018. DOI:10.1126/scitranslmed.aao4953 - Asano T, Igarashi H, Ishizuka T, Yawo H
Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light.
Front Neurosci. 12:561, 2018. DOI:10.3389/fnins.2018.00561 - Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi Y, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T.
p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells.
Proc Natl Acad Sci U S A. 115(33):8370-8375, 2018. DOI:10.1073/pnas.1804243115 - S?nchez-Mart?n P, Komatsu M.
p62/SQSTM1 - steering the cell through health and disease.
J Cell Sci. 131, 2018. DOI:10.1242/jcs.222836 - S?nchez-Mart?n P, Saito T, Komatsu M.
p62/SQSTM1: 'Jack of all trades' in health and cancer.
FEBS J. , 2018. DOI:10.1111/febs.14712 - Kajiwara C, Fumoto K, Kimura H, Nojima S, Asano K, Odagiri K, Yamasaki M, Hikita H, Takehara T, Doki Y, Morii E, Kikuchi A.
p63-dependent Dickkopf3 expression promotes esophageal cancer cell proliferation via CKAP4.
Cancer Res. 78:3471-3484, 2018. DOI:10.1158/0008-5472.CAN-18-1749 - Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T, Kuniyasu H
Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma.
Histopathol 70(4):539-548, 2018. DOI:10.1111/his.13097 - Heiss JE, Yamanaka A, Kilduff TS.
Parallel arousal pathways in the lateral hypothalamus.
eNeuro 5, 2018. DOI:10.1523/ENEURO.0228-18.2018 - Black SW, Sun JD, Santiago P, Laihsu A, Kimura N, Yamanaka A, Bersot R, Humphries PS
Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration.
Sleep 41(9), 2018. DOI:10.1093/sleep/zsy116 - Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger G, Wang J, Dong Y, Zhou Y, Wang J, Wu LY, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, et al.
Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
Cancer Discovery 8(11):1438-57, 2018. DOI:10.1158/2159-8290.CD-17-1203 - Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H
Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes.
Chem Res Toxicol 31(10):1025-1031, 2018. DOI:10.1021/acs.chemrestox.8b00067 - Yu Chen, Masahiro Takikawa, Shuichi Tsutsumi, Yoko Yamaguchi, Atsushi Okabe, Mayuna Shibata, Tatsuya Kawase, Akane Sada, Issei Ezawa, Yuhei Takano, Kisaburo Nagata, Yutaka Suzuki, Kentaro Semba, Hiroyuki Aburatani, Rieko Ohki.
PHLDA1, another PHLDA family protein that inhibits Akt.
Cancer Science 109:3532-3542, 2018. DOI:10.1111/cas.13796 - Yashiro R, Murota Y, Nishida KM, Yamashiro H, Fujii K, Ogai A, Yamanaka S, Negishi L, Siomi H, Siomi MC.
Piwi Nuclear Localization and Its Regulatory Mechanism in Drosophila Ovarian Somatic Cells.
Cell Reports 23:3647-3657, 2018. DOI:10.1016/j.celrep.2018.05.051 - Saito M, Ichikawa J, Ando T, Schoenecker JG, Ohba T, Koyama K, Suzuki-Inoue K, Haro H.
Platelet-Derived TGF-β Induces Tissue Factor Expression via the Smad3 Pathway in Osteosarcoma Cells.
J Bone Miner Res. 33(11):2048-2058, 2018. DOI:10.1002/jbmr - Toshiyama, R., Konno, M., Eguchi, H., Takemoto, H., Noda, T., Asai, A., Koseki, J., Haraguchi, N., Ueda, Y. Matsushita, K., Asukai, K., Ohashi, T., Iwagami, Y., Yamada, D., Sakai, D., Asaoka, T., Kudo, T., Kawamoto, K., Gotoh, K., Kobayashi, S., Satoh, T., Doki, Y., Nishiyama, N., Mori, M.
Poly(ethylene glycol)?poly(lysine) block copolymer?ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.
Oncogene , 2018. DOI:10.1038/s41388-018-0406-x - Tamari, K., Konno, M., Asai, A., Koseki., Jun., Hayashi, K., Kawamoto, K., Murai, N., Matsufuji, S., Isohashi, F., Satoh, T., Goto, N., Tanaka, S., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells.
Cell Death Discovery 4(104), 2018. DOI:10.1038/s41420-018-0117-7 - Fink J, Matsumoto M, Tamura Y.
Potential application of testosterone replacement therapy as treatment for obesity and type 2 diabetes in men.
Steroids 161:161-166., 2018. DOI:10.1016/j.steroids.2018.08.002 - Koide H, Shiga A, Komai E, Yamato A, Fujimoto M, Tamura A, Kono T, Nakayama A, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Suzuki S, Takeda Y, Shibuya M, Nishioka H, Yamada S, Inoshita N, Ishiwatari N, Horiguchi K, Yokote K, Tanaka T.
Prednisolone-responsive Postpartum IgG4-related Hypophysitis.
Intern Med 57(3):367-375, 2018. DOI:10.2169/internalmedicine - Miyazawa, Y., Takahashi, Y., Watabe, A.M. and Kato F.
Predominant synaptic potentiation and activation of the right central amygdala are independent of bilateral paracrachial activation in the hemilateral trigeminal inflammatory pain model of rats.
Molecular Pain :14:1744806918807102, 2018. DOI:10.1177/1744806918807102 - Ng IK, Lee J, Ng C, Kosmo B, Chiu L, Seah E, Mok MMH, Tan K, Osato M, Chng WJ, Yan B, Tan LK.
Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation.
Biomark Res. 6:16, 2018. DOI:10.1186/s40364-018-0130-2 - Aoto Y, Okumura K, Hachiya T, Hase S, Sato K, Wakabayashi Y, Ishikawa F and Sakakibara Y.
Prospective study of the tumorigenesis process with an experimental carcinogenesis model.
Scientific Reports 8(1):12994, 2018. DOI:10.1038/s41598-018-31349-x - Abe K, Yawo H.
Quantitative study of the somatosensory sensitization underlying cross-modal plasticity.
PLoS One 13(12):e0208089, 2018. DOI:10.1371/journal.pone.0208089 - Tocan V, Ohkubo K, Higashi K, Toda N, Kojima-Ishii K, Nishiyama K, Ishimura M, Takada H, Sakamoto O, Sasaki F, Yoshimura K, Hirose S, Ohga S.
Reappraising newborn screening for cobalamin C disorder.
Pediatrics & Neonatology 59(4):415-417, 2018. DOI:10.1016/j.pedneo.2017.11.002 - Motohiro Kojima, Yu Chen, Koji Ikeda, Yuichiro Tsukada, Daigoro Takahashi, Shingo Kawano, Kota Amemiya, Masaaki Ito, Rieko Ohki, Atsushi Ochiai.
Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients.
Scientific Reports 9(1):2404, 2018. DOI:10.1038/s41598-018-37707-z - Sakamoto, K., Katayama, R., Asaka, R., Sakata, S., Baba, S., Nakasone, H., Takakuwa, E., Yamazaki, R., Takizawa, J., Maeda, T., Narita, M., Izutsu, K., Kanda, Y., Ohshima, K. and *Takeuchi, K.,
Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response.
Leukemia 32:2590?2603, 2018. DOI:10.1038/s41375-018-0154-5 - Watanabe E, Fujita T, Shimono M, Koike H, Yasumoto S, Hirose S.
Recurrent autonomic and sensory neuropathy in a patient with anti-ganglionic acetylcholine receptor antibodies.
eNeurologicalSci 12:36-38, 2018. DOI:10.1016/j.ensci.2018.08.001 - Shen YC, Sasaki T, Matsuyama T, Yamashita T, Shichida Y, Okitsu T, Yamano Y, Wada A, Ishizuka T, Yawo H, Imamoto Y.
Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues.
Biochemistry 57(38):5544-5556, 2018. DOI:10.1021/acs.biochem.8b00583 - Mon, E.E., *Wei, F.-Y., Ahmad, R.N.R., Yamamoto, T., Moroishi, T., *Tomizawa, K.
Regulation of mitochondrial iron homeostasis by sideroflexin 2.
J. Physiol. Sci. 69:359-373, 2018. - Kurataka Otsuka, Yusuke Yamamoto, Takahiro Ochiya
Regulatory role of resveratrol, a microRNA-controlling compound, in?HNRNPA1?expression, which is associated with poor prognosis in breast cancer.
Oncotarget 9(37):24718-24730, 2018. DOI:10.18632/oncotarget.25339 - Jinnai, W. Nakamura, S. Koyano, K. Yamato, S.
Wakabayashi, T. Htun, Y. Nakao, Y. Iwase, T. Nakamura, M. Yasuda, S. Ueno, M. Miki, T.Kusaka T
Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglets.
Brain Dev 40(8):649-661, 2018. DOI:10.1016/j.braindev.2018.04.010 - Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
Resting-state functional connectivity analysis of the mouse brain using intrinsic optical signal imaging of cerebral blood volume dynamics.
Physiological Measurement 39:54003, 2018. DOI:10.1088/1361-6579/aac033 - Miyazaki K, Miyazaki KW, Yamanaka A, Tokuda T, Tanaka KF, Doya K.
Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience.
Nat Commun 9:2048, 2018. DOI:10.1038/s41467-018-04496-y - Ide S ; Ikekubo Y ; Hua J ; Takamatsu Y ; Uhi GR ; Sora I
Reward-enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice: A model of attention-deficit/hyperactivity disorder.
Neuropsychopharmacol Rep 38:149-153, 2018. DOI:10.1002/npr2.12020 - Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
Cancer Science 109(12):4003-4014, 2018. DOI:10.1111/cas.13805 - Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N
Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.
Int J Mol Sci. 19(6):E1811, 2018. DOI:10.3390/ijms19061811 - Takuma Watanabe, Haruka Abe, Yuichiro Mutoh, and Shinichi Saito
Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylstyrenes via 1,2-Carbon Migration that Leads to Substituted Naphthalenes.
CHEMISTRY-A EUROPEAN JOURNAL 24:11545-11549, 2018. DOI:10.1002/chem.201802413 - Hashimoto Y, Hata T, Tada M, Iida M, Watari A, Okada Y, Doi T, Kuniyasu H, Yagi K, Kondoh M
Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2.
Eur J Pharm Sci 117:161-167, 2018. DOI:10.1016/j.ejps.2018.02.016 - Koso H, Nishinakamura R, Watanabe S
Sall1 regulates microglial morphology cell autonomously in the developing retina.
Adv Exp Med Biol :209-215, 2018. DOI:10.1007/978-3-319-75402-4_26 - Eguchi N, Sora I, Muguruma K.
Self-organizing Cortex Generated From Human iPSCs With Combination of FGF2 and Ambient Oxygen.
Biochem Biophys Res Commun. 498(4):729-735, 2018. DOI:10.1016/j.bbrc.2018.03.049 - Tominaga, K., Minato, H., Murayama, T., Sasahara, A., Nishimura, T., Kiyokawa, E., Kanauchi, H., Shimizu, S., Sato, A., Nishioka, K., Tsuji, E., Yano, M., Ogawa, T., Ishii, H., Mori, M., Akashi, K., Okamoto, K., Tanabe, M., Tada, K., Tojo, A., Gotoh, N.
Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.
Proc. Natl. Acad. Sci. U. S. A. 116:625-630, 2018. DOI:10.1073/pnas.1806851116 - Matsushima-Otsuka S, Fujiwara-Tani R, Sasaki T, Ohmori H Nakashima C, Kishi S, Nishiguchi Y, Fujii K, Luo Y, Kuniyasu H
Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma.
Oncotarget 9(93):36561-36574, 2018. DOI:10.18632/oncotarget.26337 - Fukuda M, Yoshizawa T, Karim MF, Sobuz SU, Korogi W, Kobayashi D, Okanishi H, Tasaki M, Sawa T, Oike Y, Araki N, Takeda S, Mizuta H, Yamagata K
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
Nat. Commun. 9:2833, 2018. DOI:10.1038/s41467-018-05187-4 - Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K
SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.
Biochem Biophys Res Commun 496:891-897, 2018. DOI:10.1016/j.bbrc.2018.01.129 - Miyasato Y, Yoshizawa T, Sato Y, Nakagawa T, Miyasato Y, Kakizoe Y, Kuwabara T, Adachi M, Lanni A, Braun T, Komohara Y, Mukoyama M, Yamagata K
Sirtuin 7 deficiency ameliorates cisplatin-induced acute kidney injury through regulation of the inflammatory responses.
Sci Rep 8:5927, 2018. DOI:10.1038/s41598-018-24257-7 - Tsuge M, Osaki M, Sasaki R, Hirahata M, Okada F
SK-216, a novel inhibitor of plasminogen activator inhibitor-1, suppresses lung metastasis of human osteosarcoma.
Int J Mol Sci 19(3):736, 2018. DOI:10.3390/ijms19030736 - Mitsuko Furuya, Hironori Kobayashi, Masaya Baba, Takaaki Ito, Reiko Tanaka, Yukio Nakatani
Splice-site mutation causing partial retention of intron in the FLCN gene in Birt-Hogg-Dub? syndrome: a case report.
BMC medical genomics 11, 2018. DOI:10.1186/s12920-018-0359-5 - Sumiyoshi K, Koso H, Watanabe S.
Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma.
Cancer Sci. 109(5):1513-1523, 2018. DOI:10.1111/cas.13579 - Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T*, Sato K
Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis.
Mol Cancer Res 16(3):554-563, 2018. DOI:10.1158/1541-7786.MCR-17-0393 - Shimizu Y1, Tamada S1, Kato M1, Takeyama Y1, Fujioka M2, Kakehashi A2, Nakatani T1, Wanibuchi H2, Gi M2.
Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer.
Exp Ther Med 16(6):4463-4470, 2018. DOI:10.3892/etm.2018.6787 - Zhang, Z., U. Ohto, T. Shibata, M. Taoka, Y. Yamauchi, R. Sato, N. M. Shukla, S. A. David, T. Isobe, K. Miyake, and T. Shimizu.
Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep 25(12):3371-3381, 2018. DOI:10.1016/j.celrep.2018.11.081 - Ishida, H., U. Ohto, T. Shibata, K. Miyake, and T. Shimizu.
Structural basis for species-specific activation of mouse Toll-like receptor 9.
FEBS Lett 592(15):2636-2646, 2018. DOI:10.1002/1873-3468.13176 - Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Ishitani R, Tokunaga F, Kasuya G, Nureki O.
Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
Nat Commun. 9:4424, 2018. DOI:10.1038/s41467-018-06922-7 - Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ.
Study on the tumor-induced angiogenesis using mathematical models.
Cancer Science 109:15-23, 2018. DOI:10.1111/cas.13395 - Akatsuka S, Li GH, Toyokuni S
Superiority of rat over murine model for studies on the evolution of cancer genome.
Free Radical Research 52:1323-1327, 2018. DOI:10.1080/10715762.2018.1467562 - Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output.
Cell Rep. 25:2704-2715, 2018. DOI:10.1016/j.celrep.2018.11.016 - Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S. and Irie, K.
Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin.
Heterocycles 97(1):478-492, 2018. DOI:10.3987/COM-18-S(T)37 - Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
Systematic review of pre-clinical chronic myeloid leukaemia.
Int J Hematol. 108(5):465-484, 2018. DOI:10.1007/s12185-018-2528-x - Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H
Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
Sci Rep. 8(1):5435, 2018. DOI:10.1038/s41598-018-23810-8 - de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu To, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R
Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds.
EMBO Mol Med 10(10):e9024, 2018. DOI:10.15252/emmm.201809024 - Okada K, Nishizawa K, Setogawa S, Hashimoto K, Kobayashi K.
Task-dependent function of striatal cholinergic interneurons.
Eur J Neurosci 47(10):1174-1183., 2018. DOI:10.1111/ejn.13768 - Kita Y., Katayama Y., Shiraishi T., Oka T., Sato T., Suyama M., Ohkawa Y., Miyata K., Oike Y., Shirane M., Nishiyama M., Nakayama KI.
The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.
Cell Rep. 23:1988-2000, 2018. DOI:10.1016/j.celrep.2018.04.050 - Matsumoto A., Nakayama KI.
The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.
Cell Struct. Funct. 43:75-83, 2018. DOI:10.1247/csf.18005 - Pelka, K., D. Bertheloot, E. Reimer, K. Phulphagar, S. V. Schmidt, A. Christ, R. Stahl, N. Watson, K. Miyake, N. Hacohen, A. Haas, M. M. Brinkmann, A. Marshak-Rothstein, F. Meissner, and E. Latz.
The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.?.
Immunity 48(5):911-922, 2018. DOI:10.1016/j.immuni.2018.04.011 - Lorente J, Velandia C, Leal JA, Garcia-Mayea Y, Lyakhovich A, Kondoh H, LLeonart ME.
The interplay between autophagy and tumorigenesis: exploiting autophagy as a means of anticancer therapy.
Biol Rev Camb Philos Soc. 93, 1:P152?165, 2018. DOI:10.1111/brv.12337 - Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H, Kirita T.
The multifarious functions of pyruvate kinase M2 in oral cancer cells.
Int J Mol Sci 19:2907, 2018. DOI:10.3390/ijms19102907 - Jin F, Li X, Deng Y, Timilshina M, Huang B, Kim DY, Chang JH, Ichinose H, Baek SH, Murakami M, Lee YJ, Chang HW
The orphan nuclear receptor NR4A1 promotes FcepsilonRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis.
Allergy 74(6):1145-1156, 2018. DOI:10.1111/all.13702 - Okumura K, Saito M, and Wakabayashi Y.
The role of PTH in mouse skin tumorigenesis.
Integrative Cancer Science and Therapeutics 5:2, 2018. DOI:10.15761/ICST.1000271 - Kawamura Y, Yamanaka K, Poh B, Kuribayashi H, Koso H, Watanabe S
The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development.
Biochem Biophys Res Commun 503(4):3023-3030, 2018. DOI:10.1016/j.bbrc.2018.08.088 - M. Ishido*
The temporal turning window for rat behavioral phenotypes by rotenone.
Fund. Toxicol. Sci. 5, 2018. - Ihara T,Mitsui T,Nakamura Y,Kanda M,Tsuchiya S,Kira S,Nakagomi H,Sawada N,kamiyama M, Shigetomi E,Shinozaki Y,Yoshiyama M,Nakao A,Takeda M,Koizumi S.
The time-dependent variation of ATP release in mouse primary-cultured urothlial cells is regulated by the clock gene.
Neurourol Urodym. 37:2535-2543, 2018. DOI:10.1002/nau.23793 - Futakuchi M, Nitanda T, Ando S, Matsumoto H, Yoshimoto E, Fukamachi K, Suzui M
Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment.
Int J Mol Sci 19(3), 2018. DOI:10.3390/ijms19030888 - Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama S
Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells.
Scientific Reports 8:6760, 2018. DOI:10.1038/s41598-018-25189-y - Ohto, U., H. Ishida, T. Shibata, R. Sato, K. Miyake, and T. Shimizu.
Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.?.
Immunity 48(4):649-658, 2018. DOI:10.1016/j.immuni.2018.03.013 - Kurihara Y, Makita Y, Kawashima M, Fujita T, Iwasaki S, and Matsui M.
Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis.
Proc Natl Acad Sci USA 115(30):7831-7836, 2018. DOI:10.1073/pnas.1804971115 - Maeda A, Nishino T, Matsuzaki R, Yokoyama A, Suga H, Yagi T, Konishi H.
Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling.
Biochim Biophys Acta Mol Cell Res. 1866:285-295, 2018. DOI:10.1016/j.bbamcr.2018.11.009 - Momohara Y., Aonuma H. and Nagayama T.
Tyraminergic modulation of agonistic outcomes in crayfish.
J. Comp. Physiol. 204:465-473, 2018. DOI:10.1007/s00359-018-1255-3 - Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K,
Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.
UBL3 modification influences protein sorting to small extracellular vesicles.
Nature Communications 9:3936, 2018. DOI:10.1038/s41467-018-06197-y - Taiwa K, Yokoi S, Mito M2, Fujii K, Kimura Y, Iwasaki S, Nakagawa S.
UPA-Seq: Prediction of Functional LncRNAs Using Differential Sensitivity to UV Crosslinking.
RNA 24(12):1785-1802., 2018. DOI:10.1261/rna.067611.118 - Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Nameta M, Zhang L, Iwakura Y, Nawa H, Higuchi M, Komatsu M, Fujii M.
USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis.
iScience. 9:433-450, 2018. DOI:10.1016/j.isci.2018.11.006 - Shimizu A, Zankov DP, Kurokawa-Seo M, Ogita H.
Vascular endothelial growth factor-A exerts diverse cellular effects via small G proteins, Rho and Rap.
Int J Mol Sci 19:E1203, 2018. DOI:10.3390/ijms19041203 - Huizi Li, Aya Sugyo, Atsushi Tsuji, Yukie Morokoshi, Katsuyuki Minegishi, Kotaro Nagatsu, Hiroaki Kanda, Yosuke Harada, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Tatsuya Higashi, Sumitaka Hasegawa
α-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibody against frizzled homolog 10.
Cancer Science 109(7):2302-2309, 2018. DOI:10.1111/cas.13636 - Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H.
β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.
PLoS ONE 13(5):e0196946, 2018. DOI:10.1371/journal.pone.0196946 - 佐藤信吾
がん骨転移のメカニズムの新知見と創薬への可能性.
PHARM STAGE 18(3):54-58, 2018. - 佐藤信吾
がん細胞由来分泌型マイクロRNAが造骨型骨転移を惹起する.
臨床雑誌整形外科 69(11):1124, 2018. - Kojiro Ishibashi, Riku Egami, Kazuki Nakai, Shunsuke Kon
がん変異細胞が産生されたときの代謝変化に関する総説.
Cell Structure and Function 43:171-176, 2018. DOI:10.1247/csf.18018 - Vu HT, Kobayashi M, Hegazy AM, Tadokoro Y, Ueno M, Kasahara A, Takase Y, Nomura N, Peng H, Ito C, Ino Y, Todo T, Nakada M, Hirao A.
グリオーマ幹細胞の治療抵抗性におけるオートファジーの役割.
Cancer Sci 109:2497-2508, 2018. DOI:10.1111/cas.13695 - 和田裕一, 三浦知志, 窪俊一
マンガの読みにおける状況モデルの更新.
マンガ研究 24:93-114, 2018. - 外川 龍之介, 奥畑 大悟, 吉田 侑冬，中尾 光之, 片山 統裕
眼位・瞳孔径変動を考慮した内因性光信号イメージングに基づく覚醒時マウス脳視野地図の推定.
生体医工学 :in press, 2018. - Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi N, Hirao A
高脂肪食ストレスによる幹細胞制御の破綻.
Cell Stem Cell 22:713-725, 2018. DOI:10.1016/j.stem.2018.04.002 - Zhang Y, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Yamamori H, Boku S, Horai T, Someya T, Ohmori T, Hashimoto R, Sora I
高齢の統合失調症におけるより長いテロメアと、日本人の長期入院との関連.
J Psychiatr Res. 103:161-166, 2018. DOI:10.1016/j.jpsychires.2018.05.014 - Shunsuke Kon.
細胞競合の生理的、病理的な役割に関する総説.
Development, Growth and Differentiation 60:14-20, 2018. DOI:10.1111/dgd.12415 - 岡田正康, 棗田学, 河嵜麻実, 大石誠, 藤井幸彦, 五十嵐道弘
細胞突起形成抑制による膠芽腫治療戦略.
新潟県医師会報 814(1):9-10, 2018. - 古瀬 民生, 若菜 茂晴
胎児期栄養は発達障害の環境要因となりうるのか.
日本衛生学雑誌 73:97-100, 2018. DOI:10.1265/jjh.73.97 - 石堂正美
超低周波電磁界の神経幹細胞に及ぼす影響評価に関する研究.
磁気と健康 30:20-25, 2018. - Nakamura S, Koyama T, Izawa N, Nomura S, Fujita T, Omata Y, Minami T, Matsumoto M, Nakamura M, Fujita-Jimbo E, Momoi T, Miyamoto T, Aburatani H, Tanaka S
Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1.
PLoS One 12(4):e0175632, 2017. DOI:10.1371/journal.pone.0175632
2017年度
- Kotaki R, Kawashima M, Yamamoto Y, Higuchi H, Nagashima E, Kurosaki N, Takamatsu M, Kikuti YY, Imadome KI, Nakamura N, Kotani A.
Dasatinib exacerbates splenomegaly of mice inoculated with Epstein-Barr virus-infected lymphoblastoid cell lines.
Sci Rep. 10(1):4355, 2020. - T. Yamada, A. Tanaka, T. Nehira, T. Nishii, T. Kikuchi
Altercrasins A-E, decalin derivatives, from a sea-urchin-derived Alternaria sp.: isolation and structural analysis including stereochemistry.
Marine Drugs 17:218, 2019. DOI:10.3390/md17040218 - T. Yamada, A. Fujii, T. Kikuchi
New diterpenes with a fused 6-5-6-6 ring system isolated from the marine sponge-derived fungus Trichoderma harzianum.
Marine Drugs 17:480, 2019. DOI:10.3390/md17080480 - Ito T, Oti T, Takanami K, Satoh K, Ueda Y, Sakamoto T, Sakamoto H.
A sexually dimorphic peptidergic system in the lower spinal cord controlling penile function in non-human primates.
Spinal cord 56(1):57-62, 2018. DOI:10.1038/sc.2017.105 - Yamada T, Imamachi N, Onoguchi-Mizutani R, Imamura K, Suzuki Y, Akimitsu N
5'-Bromouridine IP Chase (BRIC)-Seq to Determine RNA Half-Lives.
Methods Mol Biol 1720:1-13, 2018. DOI:10.1007/978-1-4939-7540-2_1 - Inoue D, Fujino T, Sheridan P, Zhang Yz, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata KC, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang FC, Oyama M, Kitamura T
A novel ASXL1?OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.
Leukemia 32(6):1327-1337, 2018. DOI:10.1038/s41375-018-0083-3 - Meikui Wu,Makoto Takemoto,Huan Luo,Jian-Jun Xu,Mei-Hong Lu,Masaki Kameyama,Toru Takumi,Wen-Jie Song.
A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1.
Eur J Pharmacology 824:99-107, 2018. DOI:10.1016/j.ejphar.2018.02.013 - Shinno, N., Kimura, H., Sada, R., Takiguchi, S., Mori, M., Fumoto, K., Doki, Y., and Kikuchi, A.
Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.
Oncogene 37:6107-6120, 2018. DOI:10.1038/s41388-018-0179-2 - Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y, Muto A, Okano H,?Yamanaka A, Tawfik VL, Kuzumaki N, Navratilova E, Porreca F, *Narita M.
Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer.
Molecular Pain 14:1744806918756400, 2018. DOI:10.1177/1744806918756406 - Ueno H, Takao K, Suemitsu S, Murakami S, Kitamura N, Wani K, Okamoto M, Aoki S, Ishihara T
Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex.
Neurochem Int 112:59-70, 2018. DOI:10.1016/j.neuint - Hashimoto M, Yamanaka A, Kato S, Tanifuji M, Kobayashi K, Yaginuma H.
Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus.
Frontiers in Neural Circuit 12:6, 2018. DOI:10.3389/fncir.2018.00006 - Sobue A, Ito N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K.
Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes.
Glia 66:1034-1052, 2018. DOI:10.1002/glia.23299 - Kitamura T.
ASXL1 mutations gain a function.
Blood 131(3):274-275, 2018. DOI:10.1182/blood-2017-12-816595 - Prabakaran T, Bodda C, Krapp C, Zhang BC, Christensen MH, Sun C, Reinert L, Cai Y, Jensen SB, Skouboe MK, Nyengaard JR, Thompson CB, Lebbink RJ, Sen GC, van Loo G, Nielsen R, Komatsu M, Nejsum LN, Jakobsen MR, Gyrd-Hansen M, Paludan SR.
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.
EMBO J. , 2018. DOI:10.15252/embj.201797858 - Moriguchi S, Ishizuka T, Yabuki Y, Shioda N, Sasaki Y, Tagashira H, Yawo H, Yeh JZ, Sakagami H, Narahashi T, Fukunaga K.
Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy.
Mol Psychiatry. 23(2):211-221, 2018. DOI:10.1038/mp.2016.187 - Hayashida T, Saito Y, Ishii A, Yamada H, Itakura A, Minato T, Fukuyama T, Maegaki Y, Hirose S.
CACNA1A-related early-onset encephalopathy with myoclonic epilepsy: A case report.
Brain & Development 40(2):130-133, 2018. DOI:10.1016/j.braindev.2017.08.006 - Hashimoto K, Ochi H, Sunamura S, Kosaka N, Mabuchi Y, Fukuda T, Yao K, Kanda H, Ae K, Okawa A, Akazawa C, Ochiya T, Futakuchi M, Takeda S, Sato S
Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A.
Proc Natl Acad Sci U S A 115(9):2204-2209, 2018. DOI:10.1073/pnas.1717363115 -
Mito M., Kadota M., Tanaka K., Furuta Y., Abe K., Iwasaki S.*, and Nakagawa S.
Cell-type specific survey of epigenetic modifications by tandem chromatin immunoprecipitation sequencing.
Scientific Reports 8:1143, 2018. DOI:10.1038/s41598-018-19494-9 - Nakamura, Y., Nakamura, K.
Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability.
Pfl?gers Archiv - European Journal of Physiology 470:823-837, 2018. DOI:10.1007/s00424-017-2090-z - Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, Nabeshima T.
Cerebellar α6 subunit-containing GABAA receptors: A novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders.
Br J Pharmacol. 175(12):2414-2427, 2018. DOI:10.1111/bph.14198 - Sakai E., Nakayama M., Oshima H., Kouyama Y., Niida A., Fujii S., Ochiai A., Nakayama KI., Mimori K., Suzuki Y., Hong CP., Ock CY., Kim SJ., Oshima M.
Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.
Cancer Res. 78(5):1334-1346, 2018. DOI:10.1158/0008-5472.CAN-17-3303 - Kaizuka T, Hayashi T
Comparative analysis of palmitoylation sites of serotonin (5-HT) receptors in vertebrates.
Neuropsychopharmacology Reports 38:75-85, 2018. DOI:10.1002/npr2.12011 - Hagihara H., Catts VS., Katayama Y., Shoji H., Takagi T., Huang FL., Nakao A., Mori Y., Huang KP., Ishii S., Graef IA., Nakayama KI., Shannon Weickert C., Miyakawa T.
Decreased brain pH as a shared endophenotype of psychiatric disorders.
Neuropsychopharmacology 43:459-68, 2018. DOI:10.1038/npp.2017.167 - *Fakruddin M, *Wei FY, Suzuki T, Asano K, Kaieda T, Omori A, Izumi R, Fujimura A, Kaitsuka T, Miyata K, Araki K, Oike Y, Scorrano L, Suzuki T, Tomizawa K.
Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
Cell Rep 22:482-496, 2018. - Nakayama S., Yumimoto K., Kawamura A., Nakayama KI.
Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7?in a manner dependent on the kinase GSK-3.
J. Biol. Chem. 293(15):5705-5714, 2018. DOI:10.1074/jbc.RA117.000741 - Eisuke Sato, Maho Morita, Haruo Ogawa, Masato Iwatsuki, Rei Hokari, Aki Ishiyama, Satoshi ?mura, Arihiro Iwasaki and Kiyotake Suenaga
Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ pump inhibitor from marine cyanobacteria.
Bioorganic & Medicinal Chemistry Letters 28 (3):298-301, 2018. DOI:10.1016/j.bmcl.2017.12.050 - Suda Y, Kuzumaki N, Narita M, Hamada Y, Shibasaki M, Tanaka K, Tamura H, Kawamura T, Kondo T,?Yamanaka A, *Narita M.
Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors.
Biochemical and Biophysical Research Communications? 496(4):1102-1108, 2018. DOI:10.1016/j.bbrc.2018.01.145 - Kusumoto Y, Okuyama H, Shibata T, Konno K, Takemoto Y, Maekawa D, Kononaga T, Ishii T, Akashi-Takamura S, Saitoh SI, Ikebuchi R, Moriya T, Ueda M, Miyake K, Ono S, Tomura M.
Epithelial Membrane Protein 3 (Emp3) Downregulates Induction and Function of Cytotoxic T Lymphocytes by Macrophages via TNF-α Production.
Cell Immunol. 30(2):43-51, 2018. DOI:10.1016/j.cellimm.2017.12.001 - Ikenoue T, Terakado Y, Zhu C, Liu X, Ohsugi T, Matsubara D, Fujii T, Kakuta S, Kubo S, Shibata T, Yamaguchi K, Iwakura Y, Furukawa Y.
Establishment and Analysis of a Novel Mouse Line Carrying a Conditional Knockin Allele of a Cancer-Specific FBXW7 Mutation.
Sci Rep. 8:2021, 2018. DOI:10.1038/s41598-018-19769-1 - Arakawa, H., & Iguchi, Y.
Ethological and multi-behavioral analysis of learning and memory performance in laboratory rodent models.
Neuroscience Research 135:1-12, 2018. DOI:10.1016/j.neures.2018.02.001 - Lucas BA, Lavi E, Shiue L, Cho H, Katzman S, Miyoshi K, Siomi MC, Carmel L, Ares M Jr, Maquat LE.
Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay.
Proc Natl Acad Sci U S A. 115:968-973, 2018. DOI:10.1073/pnas.1715531115 - Yamazaki M, Yamada H, Munetsuna E, Ishikawa H, Mizuno G, Mukuda T, Mouri A, Nabeshima T, Saito K, Suzuki K, Hashimoto S, Ohashi K.
Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter.
FASEB J. 32(5):2549-2562, 2018. DOI:10.1096/fj.201700783RR - Ueno H, Fujii K, Suemitsu S, Murakami S, Kitamura N, Wani K, Aoki S, Okamoto M, Ishihara T, Takao K
Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex.
IBRO Reports 4:22-37, 2018. DOI:10.1016/j.ibror.2018.01.002 - Nagase R, Inoue D, Pastore A, Fujino T, Hou HA, Yamasaki N, Goyama S, Saika M, Kanai A, Sera Y, Horikawa S, Ota Y, Asada S, Hayashi Y, Kawabata KC, Takeda R, Tien HF, Honda H, Abdel-Wahab O, Kitamura T.
Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.
J Exp Med.? 215(6):1729-1747, 2018. DOI:10.1084/jem.20171151 - Nakashima C, Kishi S, Fujiwara-Tani R, Luo Y, Kawahara I, Goto K, Fujii K, Ohmori H, Kuniyasu H
Expression of the long-chain fatty acid receptor GPR40 was associated with cancer progression in colorectal cancer.
Oncol Lett 15(6):8641-8646, 2018. DOI:10.3892/ol.2018.8383 - Watanabe M, Sugiura Y, Sugiyama E, Narita M, Navratilova E, Kondo T, Uchiyama N, Yamanaka A, Kuzumaki N, Porreca F, *Narita M.
Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system.
Molecular Pain 14:1744806918754930, 2018. DOI:10.1177/1744806918754934 - Ohtsuka J, Oshima H, Ezawa I, Abe R, Oshima M, Ohki R
Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers.
Scientific Reports 8:2291, 2018. DOI:10.1038/s41598-018-20572-1 - Kim HO, Lim JE, Kim MJ, Kang JO, Kim SM, Nam JM, Tak J, Konishi H, Nishino T, Koh IS, Jin YH, Baik HH, Kim JB, Kim MK, Choi BY, Lee SH, Jang Y, Shin J, Oh B.
GAREM1 regulates the PR interval on electrocardiograms.
J Hum Genet. 63:297-307, 2018. DOI:10.1038/s10038-017-0367-x - Kuriyama Y, Hattori M, Mitsui T, Nakano H, Oikawa D, Tokunaga F, Ishikawa O, Shimizu A.
Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency.
J Dermatol. 45:e108-e109, 2018. DOI:10.1111/1346-8138.14149 - Tanaka Y, Sone T, Higurashi N, Sakuma T, Suzuki S, Ishikawa M, Yamamoto T, Mitsui J, Tsuji H, Okano H, Hirose S.
Generation of D1-1 TALEN isogenic control cell line from Dravet syndrome patient iPSCs using TALEN-mediated editing of the SCN1A gene.
Stem Cell Research 28:100-104, 2018. DOI:10.1016/j.scr.2018.01.036 - Honda A, Ito Y, Igarashi M.
Glycoprotein M6a as a signaling transducer in neuronal lipid rafts.
Neurosci Res. 128:19-24, 2018. DOI:10.1016/j.neures.2017.11.002 - Asami Kawasak, Masayasu Okada, Atsushi Tamada, Shujiro Okuda, Motohiro Nozumi, Yasuyuki Ito, Daiki Kobayashi, Tokiwa Yamasaki, Ryo Yokoyama, Takeshi Shibata, Hiroshi Nishina, Yutaka Yoshida, Yukihiko Fujii, Kosei Takeuchi, Michihiro Igarashi
Growth Cone Phosphoproteomics Reveals that GAP-43 Phosphorylated by JNK Is a Marker of Axon Growth and Regeneration.
iScience 4:190-203, 2018. DOI:10.1016/j.isci.2018.05.019 - Nishida KM, Sakakibara K, Iwasaki YW, Yamada H, Murakami R, Murota Y, Kawamura T, Kodama T, Siomi H, Siomi MC.
Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis.
Nature 555:260-264, 2018. DOI:10.1038/nature25788 -
Naruse K., Matsuura-Suzuki E., Watanabe M., Iwasaki S.*, Tomari Y.
In vitro reconstitution of chaperone-mediated human RISC assembly.
RNA 24(1):6-11, 2018. DOI:10.1261/rna.063891.117 - Saiki A, Sakai Y, Fukabori R, Soma S, Yoshida J, Kawabata M, Yawo H, Kobayashi K, Kimura M, Isomura Y.
In Vivo Spiking Dynamics of Intra- and Extratelencephalic Projection Neurons in Rat Motor Cortex.
Cereb Cortex. 28(3):1024-1038, 2018. DOI:10.1093/cercor/bhx012 - Mikamo M., Kitagawa K., Sakai S., Uchida C., Ohhata T., Nishimoto K., Niida H., Suzuki S., Nakayama KI., Inui N., Suda T., Kitagawa M.
Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis.
J. Mol. Sci. 19:E474, 2018. DOI:10.3390/ijms19020474 - Kusuoka O, Fujiwara-Tani R, Nakashima C, Fujii K, Ohmori H, Mori T, Kishi S, Miyagawa Y, Goto K, Kawahara I, Kuniyasu H
Intermittent calorie restriction enhances epithelial-mesenchymal transition through alteration of energy metabolism in a mouse tumor model.
International Journal of Oncology 52:413-423, 2018. DOI:10.3892/ijo.2017.4229 - Suzuki K., Yamada T, Yamazaki K, Hirota M, Ishihara N, Sakamoto M, Takahashi D, Iijima H, Hase K.
Intestinal epithelial cell-specific deletion of α-mannosidase II ameliorates experimental colitis. Cell Struct. Funct.
Cell Struct. Funct. 43 (1):25-39, 2018. DOI:10.1247/csf.17022 - Futatsuki T, Yamashita A, Ikbar KN,?Yamanaka A, Arita K, Kakihana Y, *Kuwaki T
Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia.
Scientific reports 8(1):2717, 2018. DOI:10.1038/s41598-018-21252-w - Shah A., I., A., Mohammad B., A., Ito I., and Ohta K.
Involvement of Tsukushi in diverse developmental processes.
Joural of Cell Communication and Signaling. 19:205-210, 2018. DOI:10.1007/s12079-018-0452-8 - Mouri A, Ukai M, Uchida M, Hasegawa S, Taniguchi M, Ito T, Hida H, Yoshimi A, Yamada K, Kunimoto S, Ozaki N, Nabeshima T, Noda Y.
Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis.
Neuropharmacology. 133:23-37, 2018. DOI:10.1016/j.neuropharm - Ito T, Narugami M, Egawa K, Yamamoto H, Asahina N, Kohsaka S, Ishii A, Hirose S, Shiraishi H.
Long-term follow up of an adult with alternating hemiplegia of childhood and a p.Gly755Ser mutation in the ATP1A3 gene.
Brain & Development 40(3):226-228, 2018. DOI:10.1016/j.braindev.2017.11.007 - Sato S, Uchihara T, Fukuda T, Noda S, Kondo H, Saiki S, Komatsu M, Uchiyama Y, Tanaka K, Hattori N.
Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice.
Sci Rep. 8, 2018. DOI:10.1038/s41598-018-21325-w - Pernilla Roswall, -------- Akira Orimo, et al.,
Microenvironmental control of breast cancer subtype elicited by paracrine platelet derived growth factor-CC signaling.,.
Nat. Med 12, 2018. DOI:10.1038/nm.4494 - Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, McHugh TJ.
Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics.
Science 359:679-684, 2018. DOI:10.1126/science.aaq1144 - Kageyama S, Saito T, Obata M, Koide RH, Ichimura Y, *Komatsu M.
Negative regulation of the Keap1-Nrf2 pathway by a p62/Sqstm1 splicing variant.
Mol Cell Biol. , 2018. DOI:10.1128/MCB.00642-17 - Michihiro Igarashi, Motohiro Nozumi, Ling-Gang Wu, Francesca Cella Zanacchi, Istv?n Katona, L?szl? Barna, Pingyong Xu, Mingshu Zhang, Fudong Xue and Edward Boyden
New observations in neuroscience using superresolution microscopy.
J Neurosci 38(44):9459-9467, 2018. DOI:10.1523/JNEUROSCI.1678-18.2018 - Tashima R, Koga K, Sekine M, Kanehisa K, Kohro Y, Tominaga K, Matsushita K, Tozaki-Saitoh H, Fukazawa Y, Inoue K, Yawo H, Furue H, Tsuda M.
Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats.
eNeuro 5(1):ENEURO.0450-17, 2018. DOI:10.1523/ENEURO.0450-17.2018 - Nishimura M, Takemoto M, Song W-J.
Organization of auditory areas in the superior temporal gyrus of marmoset monkeys revealed by real-time optical imaging.
Brain Structure and Function 223(4):1599-1614, 2018. DOI:10.1007/s00429-017-1574-0 - Yamamoto R, Osawa T, Sasaki Y, Yamamoto S elt al.
Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth.
Oncotarget 9(12):10510-10524, 2018. - Tran HQ, Lee Y, Shin EJ, Jang CG, Jeong JH, Mouri A, Saito K, Nabeshima T, Kim HC.
PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT1A Receptor and Upregulation of Nrf2-Dependent GSH Synthesis.
Mol Neurobiol. 55(10):7802-7821, 2018. DOI:10.1007/s12035-018-0938-7 - Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Matsumoto S, Matsumoto M, Nakayama KI, Tanuma N. et. al.
Pkm1 confers metabolic advantages and promotes cell-autonomous tumor cell growth.
Cancer Cell 33(3):355-367, 2018. DOI:10.1016/j.ccell.2018.02.004 - Kishi S, Fujiwara-Tani R, Luo Y, Kawahara I, Goto K, Fujii K, Ohmori H, Nakashima C, Sasaki T, Kuniyasu H
Pro-metastatic signaling of elaidic acid, a trans fatty acid, is associated with lipid rafts.
Oncology Letters 15:4423-4426, 2018. DOI:10.3892/ol.2018.7817 - Manabu Natsumeda, Kunio Motohashi, Hironaka Igarashi, Takanori Nozawa, Hideaki Abe, Yoshihiro Tsukamoto, Ryosuke Ogura, Masayasu Okada, Tsutomu Kobayashi, Hiroshi Aoki, Hitoshi Takahashi, Akiyoshi Kakita, Koichiro Okamoto, Tsutomu Nakada, Yukihiko Fujii
Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy.
Neurosurg Rev, 41(2):641-647, 2018. DOI:10.1007/s10143-017-0908-y - Hozumi J, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Kusakabe Y, Yamada Y
Resistin Is a Novel Marker for Postoperative Pain Intensity.
Anesthesia & Analgesia 128:563-568, 2018. DOI:10.1213/ANE.0000000000003363 - Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M.
Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum.
Neuron 97(4):796-805, 2018. DOI:10.1016/j.neuron.2018.01.018 - Ito, N., Katoh, K., Kushige, H., Saito, Y., Umemoto, T., Matsuzaki, Y., Kiyonari, H., Kobayashi, D., Soga, M., Era, T., Araki, N., Furuta, Y., Suda, T., Kida, Y, and *Ohta,
Ribosome incorporation into somatic cells promotes transdifferentiation towards multipotency.
Scientific Reports, 8:1634, 2018. DOI:10.1038/s41598-018-20057-1 - Maeda A, Uchida M, Nishikawa S, Nishino T, Konishi H.
Role of N-myristoylation in stability and subcellular localization of the CLPABP protein.
Biochem Biophys Res Commun. 495:1249-1256, 2018. DOI:10.1016/j.bbrc.2017.11.112.Epub2017Nov24 - *Igarashi M, Takeuchi K, Sugiyama S
Roles of CSGalNAcT1, a key enzyme in regulation of CS synthesis, in neuronal regeneration and plasticity.
Neurochem Int 119:77-83, 2018. DOI:10.1016/j.neuint.2017.10.001 - Kikusui T, Kajita M, Otsuka N, Hattori T, Kumazawa K, Watarai A, Nagasawa M, Inutsuka A, Yamanaka A, Matsuo N, Covington HE 3rd, *Mogi K.
Sex differences in olfactory-induced neural activation of the amygdala.
Behavioural Brain Research 346:96-104, 2018. DOI:10.1016/j.bbr.2017.11.034.? - Islam MS, Wei FY, Ohta K, Shigematsu N, Fukuda T, Tomizawa K, Yoshizawa T, Yamagata K
Sirtuin 7 is involved in the consolidation of fear memory in mice.
Biochem Biophys Res Commun 495:261-266, 2018. DOI:10.1016/j.bbrc.2017.10.159 - Nakayama T, Ishii A, Yoshida T, Nasu H, Shimojima K, Yamamoto T, Kure S, Hirose S.
Somatic mosaic deletions involving SCN1A cause Dravet syndrome.
American Journal of Medical Genetics 176(3):657-662, 2018. DOI:10.1002/ajmg.a.38596 - T. Yamada, M. Matsuda, M. Seki, M. Hirose, T. Kikuchi
Sterepinic acids A-C, new carboxylic acids produced by a marine alga-derived fungus.
Molecules 23:1336, 2018. DOI:10.3390/molecules23061336 - Miyata S, Nadanaka S, Igarashi M, *Kitagawa H
Structural variation of chondroitin sulfate chains contributes to molecular heterogeneity of perineuronal nets.
Front Integr Neurosci 12:3ｰ, 2018. DOI:10.3389/fnint.2018.00003 - Tsutomu Fukuda, Minoru Komure, Gen Onodera, Masanari Kimura, Masatomo Iwao
Synthesis of 4,5-disubstituted pyrano[3,4-b]pyrrol-7(1H)-ones via Sonogashira?Hagihara cross-coupling of N-benzenesulfonyl-3-bromo-1H-pyrrole-2-carboxylate and subsequent iodine-mediated cyclization.
Heterocycles 97 (2):916－930, 2018. DOI:10.3987/COM-18-S(T)68 - Ushijima T, Fujimoto N, Matsuyama S, Kan-o M, Kiyonari H, Shioi G, Kage Y, Yamasaki S, Takeya R, Sumimoto H.
The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice.
J Biol Chem 293:148-162, 2018. DOI:10.1074/jbc.M117.813931 - Yamaguchi T, Suzuki T, Sato T, Takahashi A, Watanabe H, Kadowaki A, Natsui M, Inagaki H, Arakawa S, Nakaoka S, Koizumi Y, Seki S, Adachi S, Fukao A, Fujiwara T, Natsume T, Kimura A, Komatsu M, Shimizu S, Ito H, Suzuki Y, Penninger JM, Yamamoto T, Imai Y, Kuba K.
The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function.
Sci Signal. 11, 2018. DOI:10.1126/scisignal.aan3638 - Kimura H, Matsuyama Y, Araki S, Koizumi A, Kariya Y, Takasuga S, Eguchi S, Nakanishi H, Sasaki J, Sasaki T.
The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis.
Mod Rheumatol 28(3):530-541, 2018. DOI:10.1080/14397595.2017.1367116 - Matsumoto M.,. Nakayama KI
The promise of targeted proteomics for quantitative network biology.
Curr. Opin. Biotechnol. 54:88-97, 2018. DOI:10.1016/j.copbio.2018.02.014 - Furukawa T, Tabata S, Yamamoto M, Kawahara K, Shinsato Y, Minami K, Shimokawa M, Akiyama SI
Thymidine phosphorylase in cancer aggressiveness and chemoresistance.
Pharmacol Research 132:15-20, 2018. DOI:10.1016/j.phrs.2018.03.019 - Hashimoto Y., Shirane M., Nakayama KI.
TMEM55B contributes to lysosomal homeostasis and amino acid?induced mTORC1 activation.
Genes Cells 23(6):418-434, 2018. DOI:10.1111/gtc.12583 - Mizunoe Y, Kobayashi M, Sudo Y, Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita N, Komatsu M, Higami Y.
Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.
Redox Biol. 15:115-124, 2018. DOI:10.1016/j.redox.2017.09.007 - Kawasaki, N. Isogaya, K. Dan, S. Yamori, T. Takano, H. Yao, R. Morishita, Y. Taguchi, L. Morikawa, M. Heldin, C. H. Noda, T. Ehata, S. Miyazono, K. Koinuma, D.
TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling.
Cell Discov 4, 2018. DOI:10.1038/s41421-017-0001-2 - Bailey JN, de Nijs L, Bai D, Suzuki T, Miyamoto H, Tanaka M, Patterson C, Lin YC, Medina MT, Alonso ME, Serratosa JM, Duron RM, Nguyen VH, Wight JE, Martinez-Juarez IE, Ochoa A, Jara-Prado A, Guilhoto L, Molina Y, Yacubian EM, Lopez-Ruiz M, Inoue Y, Kaneko S, Hirose S, Osawa M, Oguni H, Fujimoto S, Grisar TM, Stern JM, Yamakawa K, Lakaye B, Delgado-Escueta AV.
Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy.
New England Journal of Medicine 378(11):1018-1028, 2018. DOI:10.1056/NEJMoa1700175 - Yeon‐Joo Kim, Daniel PS Osborn, Ji‐Young Lee, Masatake Araki, Kimi Araki, Timothy Mohun, Johanna K?ns?koski, Nina Brandstack, Hyun‐Taek Kim, Francesc Miralles, Cheol‐Hee Kim, Nigel A Brown, Hyung‐Goo Kim, Juan Pedro Martinez‐Barbera, Paris Ataliotis, Taneli Raivio, Lawrence C Layman, Soo‐Hyun Kim
WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.
EMBO reports 19:269-289, 2018. DOI:10.15252/embr.201744632 - Kurihara M, Sasahira T, Nakahiro, Nakashima C, Kuniyasu H, Kirita T
Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma.
J Clin Pathol 71(5):436-441, 2018. DOI:10.1136/jclinpath-2017-204770 - 井口善生
オペラント条件づけ―基礎理論を学ぶ.
臨床心理学 (もっと知りたいあなたのための認知行動療法ガイド) 18:7-11, 2018. - Ohta S, Kawakami Y, Okano H
MIF: functions in brain and glioma.
Oncotarget 8 (29):46706-4670, 2017. DOI:10.18632/oncotarget.18489 - Shikata Y, Kiga M, Futamura Y, Aono H, Inoue H, Kawada M, Osada H, and Imoto M.
Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor.
Cancer Science 108:785-794, 2017. DOI:10.1111/cas.13175 - Harada, T., Yamamoto, H, Kishida, S., Kishida, M., Awada, C., Takao, T., and Kikuchi, A.
Wnt5b-associated exosomes promote cancer cell migration and proliferation.
Cancer Science 108:42-52, 2017. DOI:10.1111/cas.1310 - Yuichiro Mutoh, Yusei Mohara, Shinichi Saito
(Z)-Selective Hydrosilylation of Terminal Alkynes with HSiMe(OSiMe3)2 Catalyzed by a Ruthenium Complex Containing an N-Heterocyclic Carbene.
ORGANIC LETTERS 19:5204-5207, 2017. DOI:10.1021/acs.orglett.7b02477 - 中村加枝, 林和子, 中尾和子
【予測・意思決定・情動の脳内計算機構-セロトニン研究の新展開-】 背側縫線核による報酬・嫌悪情報処理.
日本薬理学雑誌 149(1):40-43, 2017. - H Muranaka, A Hayashi, K Minami, S Kitajima, S Kohno, Y Nishimoto, N Nagatani, M Suzuki, LAN Kulathunga, N Sasaki, N Okada, T Matsuzaka, H Shimano, H Tada, C Takahashi
A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling.
Oncogenesis 6:e350, 2017. DOI:10.1038/oncsis.2017.51 - Marsman J, Thomas A, Osato M, O'Sullivan JM, Horsfield JA.
A DNA Contact Map for the Mouse Runx1 Gene Identifies Novel Haematopoietic Enhancers.
Sci Rep 7(1):13347, 2017. DOI:10.1038/s41598-017-13748-8 - M. Ishido*, R.Usu
A new insight into proliferative action of bisphenol A at low-dose.
Fund. Toxicol. Sci. 4:191-193, 2017. DOI:10.2131/fts.4.191 - Kawada, M., Inoue, H., Kajikawa, M., Sugiura, M., Sakamoto, S., Urano, S., Karasawa, C., Usami, I., Futakuchi, M., Masuda, T.
A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo.
Sci. Rep. 7:40400, 2017. DOI:10.1038/srep40400 - Ren, Y., Sekine-Kondo, E., Shibata, R., Kato-Itoh, M., Umino, A., Yanagida, A., Satoh, M., Inoue, K., Yamaguchi, T., Mochida, K., Nakae, S., Van Kaer, L., Iwabuchi, K., Nakauchi, H., Watarai, H.
A novel mouse model of iNKT cell-deficiency generated by CRISPR/Cas9 reveals a pathogenic role of iNKT cells in metabolic disease.
Sci. Rep. 7（1）:12765, 2017. DOI:10.1038/s41598-017-12475-4 - Yamamoto S, Muramatsu M, Azuma E, Ikutani M, Nagai Y, Sagara H, Koo BN, Kita S, O'Donnell E, Osawa T et al.
A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS.
Scientific Reports 7(1):3855, 2017. - Masahiro Takikawa and Rieko Ohki
A vicious partnership between AKT and PHLDA3 to facilitate neuroendocrine tumors.
Cancer Science 108(6):1101-1108, 2017. DOI:10.1111/cas.13235 - Liau WS, Tan SH, Ngoc PCT, Wang CQ, Tergaonkar V, Feng H, Gong Z, Osato M, Look AT, Sanda T.
Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia.
Leukemia 31(8):1798-1807, 2017. DOI:10.1038/leu.2016.392 - Yoshioka N, Miyata S, Tamada A, Watanabe Y, Kawasaki A, Kitagawa H, Takao K, Miyakawa T, Takeuchi K, Igarashi M
Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis.
Mol Brain 10(1):47, 2017. DOI:10.1186/s13041-017-0328-5 - Bayarsaikhan G, Miyakoda M, Yamamoto K, Kimura D, Akbari M, Yuda M and Yui K
Activation and exhaustion of antigen-specific CD8+ T cells occur in different splenic compartments during infection with Plasmodium berghei.
Parasitology International 66(3):227-235, 2017. DOI:10.1016/j.parint.2017.01.022 - Matsumoto Y, Niwa M, Mouri A, Noda Y, Fukushima T, Ozaki N, Nabeshima T.
Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice.
Psychopharmacology (Berl). 234:3055-3074, 2017. DOI:10.1007/s00213-017-4704-8 - Toba S, Jin M, Yamada M, Kumamoto K, Matsumoto S, Yasunaga T, Fukunaga Y, Miyazawa A, Fujita S, Itoh K, Fushiki S, Kojima H, Wanibuchi H, Arai Y, Nagai T, Hirotsune S.
Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport.
Sci Rep. 7(1):e16386, 2017. DOI:10.1038/s41598-017-15575-3 - Okitsu T, Matsuyama T, Yamashita T, Ishizuka T, Yawo H, Imamoto Y, Shichida Y, Wada A.
Alternative Formation of Red-Shifted Channelrhodopsins: Noncovalent Incorporation with Retinal-Based Enamine-Type Schiff Bases and Mutated Channelopsin.
Chem Pharm Bull (Tokyo). 28(3):1024-1038, 2017. DOI:10.1248/cpb.c17-00054 - Aikawa T, Watanabe T, Miyazaki T, Mikuni T, Wakamori M, Sakurai M, Aizawa H, Ishizu N, Watanabe M, Kano M, Mizusawa H, Watase K.
Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice.
Human Molecular Genetics 26(16):3094-3104, 2017. DOI:10.1093/hmg/ddx193 - Ueno K, Iwagawa T, Ochiai G, Koso H, Nakauchi H, Nagasaki M, Suzuki Y, Watanabe S
Analysis of Muller glia specific genes and their histone modification using Hes1-promoter driven EGFP expressing mouse.
Sci. Rep. 7(1):3578, 2017. DOI:10.1038/s41598-017-03874-8 - Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y
Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.
Osteoarthr Cartilage 26:108-117, 2017. DOI:10.1016/j.joca.2017.10.011 - Tanaka N, Mashima T, Mizutani A, Sato A, Aoyama A, Gong B, Yoshida H, Muramatsu Y, Nakata K, Matsuura M, Katayama R, Nagayama S, Fujita N, Sugimoto Y, Seimiya H.
APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.
Molecular Cancer Therapeutics 16(4):752-762, 2017. DOI:10.1158/1535-7163.MCT-16-0578 - Yamamoto, H., Sato, A., and Kikuchi, A.
Apical secretion of Wnt1 in polarized epithelial cells is regulated by exocyst-mediated trafficking.
J. Biochem. 162:317-326, 2017. DOI:10.1093/jb/mvx035 - Shimmyo N, Hishimoto A, Otsuka I, Okazaki S, Boku S, Mouri K, Horai T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
Association Study of MIF Promoter Polymorphisms With Suicide Completers in the Japanese Population.
Neuropsychiatr Dis Treat. 13:899-908, 2017. DOI:10.2147/NDT.S130855 - Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.
Autophagy 17:764-777, 2017. DOI:10.1080/15548627.2017.1314897 - Ishihara N, Suzuki S, Tanaka S, Watanabe Y, Nagayama D, Saiki A, Tanaka T, Tatsuno I.
Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells.
Mol Med Rep. 16(4):4756-4762, 2017. DOI:10.3892/mmr.2017.7141 - Kwon T*, Sakamoto M* (Co-first author), Peterka DS, Yuste R
Attenuation of Synaptic Potentials in Dendritc Spines.
Cell Reports 20(5):1100-1110, 2017. DOI:10.1016/j.celrep.2017.07.012 - Kuma A, Komatsu M, Mizushima N.
Autophagy-monitoring and autophagy-deficient mice.
Autophagy 13:1619-1628, 2017. DOI:10.1080/15548627.2017.1343770 - Sakagami H, Katsumata O, Hara Y, Sasaoka T, Fukaya M
BRAG2a, a guanine nucleotide exchange factor for Arf6, is a component of the dystrophin-associated glycoprotein complex at the photoreceptor terminal.
Investigative Ophthalmology and Visual Science (IOVS) 58 (9):3795-3803, 2017. DOI:10.1167/iovs.17-21746 - Morita N, Yamai I, Takahashi K, Kusumoto Y, Shibata T, Kobayashi T, Nonaka MI, Ichimonji I, Takagi H, Miyake K, Takamura SA
C4b Binding Protein Negatively Regulates TLR1/2 Response.
Innate Immun 23(1):11-19, 2017. DOI:10.1177/1753425916672312 - Shimizu T, Kamel WA, Yamaguchi-Iwai S, Fukuchi Y, Muto A, Saya H
Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response.
Cancer Science 108 (9):1793-1802, 2017. DOI:10.1111/Cas.13304 - Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H
Calmodulin kinases: essential regulators in health and disease.
Journal of neurochemistry 141(6):808-818, 2017. DOI:10.1111/jnc.14020 - Fakruddin M, Wei FY, Emura S, Matsuda S, Yasukawa T, Kang D, Tomizawa K.
Cdk5rap1-mediated 2-methylthio- N6- isopentenyl adenosine modification is absent from nuclear-derived RNA species.
Nucleic Acids Res 45:11954-11961, 2017. - Shunsuke Kon, Kojiro Ishibashi, et al.
Cell Competition With Normal Epithelial Cells Promotes Apical Extrusion of Transformed Cells Through Metabolic Changes.
Nature Cell Biology 19(5):530-541, 2017. DOI:10.1038/ncb3509 - Okumura K, Kagawa N, Saito M, Yoshizawa Y, Munakata H, Isogai E, Fukagawa T and Wakabayashi Y.
CENP-R acts bilaterally as a tumor suppressor and an oncogene in the two-stage skin carcinogenesis model.
Cancer Science 108(11):2142-2148, 2017. DOI:10.1111/cas.13348 - Okumura K, Kagawa N, Saito M, Yoshizawa Y, Munakata H, Isogai E, Fukagawa T, and Wakabayashi Y.
CENP-R acts bilaterally as a tumor suppressor and an oncogene in the two-stage skin carcinogenesis model.
Cancer Science 108(11):2142-2148, 2017. - Shinji Nakamura, Walker DW, Wong FY
Cerebral haemodynamic response to somatosensory stimulation in fetal sheep.
Journal of Physiology 595(4):1289-1303, 2017. DOI:10.1113/JP273163 - Shinji Nakamura, Walker DW, Wong FY
Cerebral haemodynamic response to somatosensory stimulation in neonatal lambs.
Journal of Physiology 595(17):6007-21, 2017. DOI:10.1113/JP274244 - Black SW,?Yamanaka A,?*Kilduff TS
Challenges in the development of therapeutics for narcolepsy.
Progress in Neurobiology 152:89-113, 2017. DOI:10.1016/j.pneurobio.2015.12.002 - Urai M, Aizawa T, Imamura K, Hamamoto H, Sekimizu K
Characterization of the chemical structure and innate immune-stimulating activity of an extracellular polysaccharide from?Rhizobium?sp. strain M2 screened using a silkworm muscle contraction assay.
Drug discoveries & therapeutics 11 (5):238-245, 2017. DOI:10.5582/ddt.2017.01045 - Okuno H, Renault Mihara F, Ohta S, Fukuda K, Kurosawa K, Akamatsu W, Sanosaka T, Kohyama J, Hayashi K, Nakajima K, Takahashi T, Wysocka J, Kosaki K, Okano H.
CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations.
Elife 6:e21114, 2017. DOI:10.7554/eLife.21114 - Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, *Igarashi M, *Sugiyama S
Chondroitin sulfate is required for onset and offset of critical period plasticity in visual cortex.
Sci Rep 7:12646-, 2017. DOI:10.1038/s41598-017-04007-x - Hashimoto Y, Fukasawa M, Kuniyasu H, Yagi K, Kondoh M
Claudin-targeted drug development using anti-claudin monoclonal antibodies to treat hepatitis and cancer.
Annals of New York Academy of Sciences 1397(1):5-16, 2017. DOI:10.1111/nyas.13337 - Luo H, Hasegawa K, Liu MS, Song W-J.
Comparison of the Upper Marginal Neurons of Cortical Layer 2 with Layer 2/3 Pyramidal Neurons in Mouse Temporal Cortex. .
Front Neuroanat 11:115, 2017. DOI:10.3389/fnana.2017.00115 - Umemura M, Ogura T, Matsuzaki A, Nakano H,?Takao?K,?Miyakawa?T, Takahashi Y
Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice.
Frontiers in Behavioral Neuroscience 11:125, 2017. DOI:10.3389/fnbeh - Hayashi T
Conservation and phylogenetic stepwise changes of aquaporin (AQP) 4 palmitoylation in vertebrate evolution.
Neurotransmitter 4:e1608, 2017. DOI:10.14800/nt.1608 - Watanabe T, Shimazaki T, Oda Y.
Coordinated expression of two types of low-threshold K+ channels establishes unique single-spiking of Mauthner cells among segmentally homologous neurons in the zebrafish hindbrain.
eNeuro 1523:0249-17, 2017. DOI:10.1523/ENEURO.0249-17.2017 - Fukutomi, M. and Ogawa, H.
Crickets alter wind-elicited escape strategies depending on acoustic context.
Sci. Rep. 7:15158, 2017. DOI:10.1038/s41598-017-15276-x - Akaike T, *Ida T, *Wei FY, *Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H.
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.
Nat Commun. 8:1177, 2017. DOI:10.1038/s41467-017-01311-y - Aoto Y, Hachiya T, Okumura K, Hase S, Sato K, Wakabayashi Y, and Sakakibara Y.
DEclust: A statistical approach for obtaining differential expression profiles of multiple conditions.
PLoS ONE 12(11):e0188285, 2017. DOI:10.1371/journal.pone.0188285 - Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H.
Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.
Sci Rep. 7:45050, 2017. DOI:10.1038/srep45050 - Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M,?Takao K,?Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T
Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior.
The Journal of Experiment Medicine 214(5):1431-1452, 2017. DOI:10.1084/jem - Takano, T., Motozono, C*., Imai, T., Sonoda, KH., Nakanishi, Y., Yamasaki, S*.
Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity.
J. Biol. Chem. 292:16933-16941, 2017. DOI:10.1074/jbc.M117.800847 - Piao X, Yamazaki S, Komazawa-Sakon S, Miyake S, Nakabayashi O, Kurosawa T, Mikami T, Tanaka M, Van Rooijen N, Ohmuraya M, Oikawa A, Kojima Y, Kakuta S, Uchiyama Y, Tanaka M, Nakano H.
Depletion of Myeloid Cells Exacerbates Hepatitis and Induces an Aberrant Increase in Histone H3 in Mouse Serum.
Hepatology 65(1):237-252, 2017. DOI:10.1002/hep.28878 - Tsutomu Fukuda, Teppei Umeki, Keiji Tokushima, Gao Xiang, Yuki Yoshida, Fumito Ishibashi, Yusuke Oku, Naoyuki Nishiya, Yoshimasa Uehara, Masatomo Iwao
Design, synthesis, and evaluation of A-ring-modified lamellarin N analogues as noncovalent inhibitors of the EGFR T790M/L858R mutant.
Bioorganic and Medicinal Chemistry 25 (24):6563-6580, 2017. DOI:10.1016/j.bmc.2017.10.030 - Syuji Kurogi, Tomohisa Sekimoto, Taro Funamoto, Tomomi Ota, Shihoko Nakamura, Takuya Nagai, Mai Nakahara, Kumiko Yoshinobu, Kimi Araki, Masatake Araki and Etsuo Chosa
Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
Sci. Rep. 7:40692, 2017. DOI:10.1038/srep40692 - Kumamoto K, Iguchi T, Ishida R, Uemura T, Sato M, Hirotsune S.
Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning.
Biol Open. 15:1041-1055, 2017. DOI:10.1242/bio.025999 - Kikuchi A., Fumoto K., Kimura H.
Dickkopf1-cytoskeleton-associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy.
Br. J. Pharmacol 174(24):4651-4665, 2017. DOI:10.1111/bph.13863 - Okubo T, Sato A, Okamoto H, Sato T, Sasaoka T
Differential behavioral phenotypes of dopamine D1 receptor knockdown mice at the embryonic, postnatal, and adult stages.
International Journal of Developmental Neuroscience 66:1-8, 2017. DOI:10.1016/j.ijdevneu.2017.11.004 - Zankov DP, Sato A, Shimizu A, Ogita H.
Differential effects of myocardial afadin on pressure overload-induced compensated cardiac hypertrophy.
Circ J 81:1862-1870, 2017. DOI:10.1253/circj.CJ-17-0394 - Jiang F-X, Li K, Archer M, Mehta M, Jamieson E, Charles A, Dickinson JE, Matsumoto M, Morahan G
Differentiation of Islet Progenitors Regulated by Nicotinamide into Transcriptome-verified β Cells that Ameliorate Diabetes.
Stem Cells 35:1341-1354, 2017. DOI:10.1002/stem.2567 - Yasuda D, Yuasa A, Obata R, Nakajima M, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.
Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor.
Bioorg Med Chem Lett. 27:5006-5009, 2017. DOI:10.1016/j.bmcl.2017.10.008 - Ueda Y, Yamanaka K, Noritake A, Enomoto K, Matsumoto N, Yamada H, Samejima K, Inokawa H, Hori Y, Nakamura K, Kimura M.
Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection.
Frontiers in Neuroanatomy 0.504166666666667, 2017. DOI:10.3389/fnana.2017.00066 - Soma S, Saiki A, Yoshida J, R?os A, Kawabata M, Sakai Y, Isomura Y
Distinct laterality in forelimb-movement representations of rat primary and secondary motor cortical neurons with intratelencephalic and pyramidal tract projections.
The Journal of Neuroscience 37(45):10904-10916, 2017. DOI:10.1523/JNEUROSCI.1188-17.2017 - M. Ishido*, R.Usu
Distinct regulation of nuclear localization of caspase-activated DNase during cadmium-induced apoptosis of the target cells.
Fund. Toxicol. Sci. 4:159-165, 2017. DOI:10.2131/fts.4.159 - Ide S, Takahashi T, Takamatsu Y, Uhl GR, Niki H, Sora I, Ikeda K.
Distinct Roles of Opioid and Dopamine Systems in Lateral Hypothalamic Intracranial Self-Stimulation.
Int J Neuropsychopharmacol. 20(5):403-409, 2017. DOI:10.1093/ijnp/pyw113 - Shindou H, Koso H, Sasaki J, Nakanishi H, Sagara H, Nakagawa KM, Takahashi Y, Hishikawa D, Iizuka-Hishikawa Y, Tokumasu F, Noguchi H, Watanabe S, Sasaki T, Shimizu T
Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells.
J. Biol. Chem 292(29):12054-12064, 2017. DOI:10.1074/jbc.M117.790568 - Yamaguchi N, Nakayama Y, Yamaguchi N
Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6.
J Biol Chem. 292(20):8136-8148, 2017. DOI:10.1074/jbc.M116.763276 - Kanki Y, Nakaki R, Shimamura T, Matsunaga T, Yamamizu K, Katayama S, Suehiro J, Osawa T et al.
Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation.
Nucleic Acids Research 45(8):4344-4358, 2017. - Nakamoto K, Aizawa F, Miyagi K, Yamashita T, Mankura M, Koyama Y, Kasuya F, Hirasawa A, Kurihara T, Miyata A, Tokuyama S.
Dysfunctional GPR40/FFAR1 Signaling Exacerbates Pain Behavior in Mice.
PLoS One 12(7):e0180610, 2017. DOI:10.1371/journal.pone.0180610 - Yuichiro Yoneoka, Masayasu Okada, Naoto Watanabe, Satoru Aoki, Akiyoshi Kakita, Yukihiko Fujii
Ectopic pituitary null cell adenoma arising from the infundibulum in the third ventricle: A successful endonasal transsphenoidal resection after long-term follow-up MR imaging ? A technical note.
Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 10:122-125, 2017. DOI:10.1016/j.inat.2017.08.004 - Masatsugu Ohgami, Nobuhiko Takai , Masahiko Watanabe, Koichi Ando, Akiko Uzawa, Ryoichi Hirayama
EFFECT OF N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST ON RADIATION-INDUCED GUT INJURIES IN MICE.
RadProc vol.2, 2017. DOI:10.21175 - Ohta Y, Kubo H, Yashiro K, Ohashi K, Tsuzuki Y, Wada N, Yamamoto Y, Saito K.
Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues.
J Physiol Sci. 67:361-372, 2017. DOI:10.1007/s12576-016-0467-y - Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T, Kuniyasu H
Elaidic acid, a trans fatty acid, enhances the metastasis of colorectal cancer cells.
Pathobiology 84(3):144-151, 2017. DOI:10.1159/000449205 - Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabe M, Sasahara M, Fukunaga K
Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons.
Molecular Psychiatry 22 (8):1205-1222, 2017. DOI:10.1038/mp.2016.200 - Hattori M, Shimizu A, Oikawa D, Kamei K, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Tokunaga F, Ishikawa O.
Endoplasmic reticulum stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa.
British Journal of Dermatology 177(4):e92-e93, 2017. DOI:10.1111/bjd.15342 - Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama, Kentaro semba, Takuya Tomita, Shigeo Murata, Hiroyuki Arai and Tomohiko Taguchi
Endosomal phosphatdylserine is critical for the YAP signaling pathway in proliferating cells.
Nature Communications 8:1246, 2017. DOI:10.1038/s41467-017-01255-3 - Goswami, D., Marz, S., Li, Y. T., Artz, A., Schafer, K., Seelige, R., Pacheco-Blanco, M., Jing, D., Bixel, M. G., Araki, M., Araki, K., Yamamura, K., Vestweber, D.
Endothelial CD99 supports arrest of mouse neutrophils in venules and binds to neutrophil PILRs.
Blood 129(13):1811-1822, 2017. DOI:10.1182/blood-2016-08-733394 - Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N
Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).
Biochem Biophys Res Commun. 490(3):1045-1051, 2017. DOI:10.1016/j.bbrc.2017.06.163 - Goyama S and Kitamura T.
Epigenetics in Normal and Malignant Hematopoiesis: An Overview and Update 2017.
Cancer Sci. 108(4):553-562, 2017. DOI:10.1111/cas.13168 - Shinohara K., Watabe, A.M. # , Nagase M., Okutsu Y., Takahashi Y., Kurihara H., Kato F.(#責任著者)
Essential Role of Endogenous Calcitonin Gene-Related Peptide in Pain-associated Plasticity in the Central Amygdala.
European Journal of Neuroscience 46(6):2149-2160, 2017. DOI:10.1111/ejn.13662 - Muto Y., Nishiyama M., Nita A., Moroishi T., Nakayama KI.
Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
Nature Commun. 8:16114, 2017. DOI:10.1038/ncomms16114 - Kondo A & Osawa T
Establishment of an extracellular acidic pH culture system.
JoVE 129:e56660, 2017. - Itoh M, Kaizuka T, Hayashi T
Evolutionary acquisition and divergence of vertebrate HCN2 palmitoylation.
Neurotransmitter 4:e1603, 2017. DOI:10.14800/nt.1603 - Yanase T, Matsumoto M, Tanaka T, Mera T, Yasunami Y, Daibo K
Expansion of transplanted islets in mice by co-transplantation with adipose tissue-derived mesenchymal stem cells.
Heliyon :e00632, 2017. DOI:10.1016/j.heliyon.2018.e00632 - Huang M, Narita S, Inoue T, Koizumi A, Saito M, Tsuruta H, Numakura K, Satoh S, Nanjo H, Sasaki T, Habuchi T
Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production.
Oncotarget 8(67):111780-111794, 2017. DOI:10.18632/oncotarget.22908 - Kawahara I, Mori T, Goto K, Fujii K, Ohmori H, Fujiwara-Tani R, Kuniyasu H
Fatty acids induce stemness in the stromal cells of a CT26 mouse tumor model.
Pathobiology 84(5):237-242, 2017. DOI:10.1159/000471854 - Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Fujiwara R, Kadochi Y, Mori S, Kuniyasu H
Fatty acids inhibit anti-cancer effect of 5-fluorouracil in mouse cancer cell lines.
Oncology Letters 14(1):681-686, 2017. DOI:10.3892/ol.2017.6190 - Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon S, Fulda S, Gascon S, Hatzios SK, Kagan V, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat G, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti F, Torti S, Toyokuni S, Woerpel KA, Zhang DD.
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease.
Cell 171:273-285, 2017. DOI:10.1016/j.cell.2017.09.021 - Suzuki-Kerr H, Baba Y, Tsuhako A, Koso H, Dekker JD, Tucker H, Kuribayashi H, Watanabe S.
Forkhead box protein P1 is essential for lens epithelium transition to the fiber cells during development but does not play roles for retinal development.
Invest. Ophthalmol. Vis. Sci. 58:1916-1929, 2017. DOI:10.1167/iovs.16-20085 - Anzai E, Hirata K, Shibazaki M, Yamada C, Morii M, Honda T, Yamaguchi N, Yamaguchi N
FOXA1 Induces E-Cadherin Expression at the Protein Level via Suppression of Slug in Epithelial Breast Cancer Cells.
Biol Pharm Bull. 40(9):1483-1489, 2017. DOI:10.1248/bpb.b17-00307 - Saito K, Ohta S, Kawakami Y, Yoshida K, Toda M
Functional analysis of KIF20A, a potential immunotherapeutic target for glioma.
J Neurooncol 132(1):63-74, 2017. DOI:10.1007/s11060-016-2360-1 - Tsunoda SP, Prigge M, Abe-Yoshizumi R, Inoue K, Kozaki Y, Ishizuka T, Yawo H, Yizhar O, Kandori H.
Functional characterization of sodium-pumping rhodopsins with different pumping properties.
PLoS One. 12(7):e0179232, 2017. DOI:10.1371/journal.pone.0179232 - Ali MAE， Fuse K， Tadokoro Y， Hoshii T， Ueno M， Kobayashi M， Nomura N， Vu HT， Peng H， Hegazy AM， Masuko M， Sone H， Arai F， Tajima A， Hirao A.
Functional Dissection of Hematopoietic Stem Cell Populations With a Stemness-Monitoring System Based on NS-GFP Transgene Expression.
Scientific Report 7:11442, 2017. DOI:10.1038/s41598-017-11909-3 - Sato M, Kokabu S, Enoki Y, Hayashi N, Matsumoto M, Nakahira M, Sugasawa M, Yoda T
Functional roles of netrin-1 in osteoblast differentiation.
In vivo 31(3):321-8, 2017. - Ostrovidov S, Ebrahimi M, Bae H, Nguyen HK, Salehi S, Kim SB, Kumatani A, Matsue T, Shi X, Nakajima K, Hidema S, Osanai M, Khademhosseini A
Gelatin-Polyaniline Composite Nanofibers Enhanced Excitation-Contraction Coupling System Maturation in Myotubes.
ACS Applied Materials & Interfaces 9(49):42444-42458, 2017. DOI:10.1021/acsami.7b03979 - Nishihara S
Glycans define the stemness of na?ve and primed pluripotent stem cells.
Glycoconj J. 34(6):737-747, 2017. DOI:10.1007/s10719-016-9740-9 - Okamoto A, Morinaga T, Yamaguchi N, Yamaguchi N
Golgi Distribution of Lyn to Caveolin- and Giantin-Positive cis-Golgi Membranes and the Caveolin-Negative, TGN46-Positive trans-Golgi Network.
Biol Pharm Bull.? 41(1):142-146, 2017. DOI:10.1248/bpb.b17-00681 - Shuji Wakatsuki, Shinji Tokunaga, Megumi Shibata,Toshiyuki Araki
GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration.
J Cell Biology 216:477, 493, 2017. DOI:10.1083/jcb.201606020 - Hasumi H, Hasumi Y, Baba M, Nishi H, Furuya M, Vocke CD, Warner AC, Haines DC, Wei MH, Zbar B, Yao M, Metwalli AR, Marston Linehan W, Schmidt LS.
H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.
Human Molecular Genetics 26(2):354-366, 2017. DOI:10.1093/hmg/ddw392 - Hideko Ohno, Yuichiro Yoneoka, Shinya Jinguji, Naoto Watanabe, Masayasu Okada, Yukihiko Fujii
Has acromegaly been diagnosed earlier?.
Journal of Clinical Neuroscience 48:138-142, 2017. DOI:10.1016/j.jocn.2017.10.086 - Zhang S., Chen Q., Liu Q., Li Y., Sun X., Hong L., Ji S., Liu C., Geng J., Zhang W., Lu Z., Yin ZY., Zeng Y., Lin KH., Wu Q., Li Q., Nakayama K., Nakayama KI., Deng X., Johnson RL., Zhu L., Gao D., Chen L., Zhou D.
Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2.
Cancer Cell 31:669-84, 2017. DOI:10.1016/j.ccell.2017.04.004 - M. Ishido*, R.Usu
HSP70-Ran-RCC1 transport system during cadmium-induced apoptosis in porcine kidney LLC-PK1 cells.
Fund. Toxicol. Sci. 4:187-189, 2017. DOI:10.2131/fts.4.187 - Goto A, Yoshimi A, Nagai T, Ukigai M, Mouri A, Ozaki N, Noda Y.
Human neutrophils show decreased survival upon long-term exposure to clozapine.
Hum Psychopharmacol. 32:e2629, 2017. DOI:10.1002/hup.2629 - Ono D, Yamanaka A
Hypothalamic regulation of the sleep/wake cycle.
Neuroscience Research 118:74-81, 2017. DOI:10.1016/j.neures.2017.03.013 - Sato Y, Tsuyama T, Sato C, Karim MF, Yoshizawa T, Inoue M, Yamagata K
Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase.
J Biol. Chem. 292:8716-8728, 2017. DOI:10.1074/jbc.M116.767574 - Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A.
Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.
Leukemia 31(4):861-871, 2017. DOI:10.1038/leu.2016.268 - Tsukada M, Ota Y, Wilkinson AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S.
In?Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma.
Stem Cell Reports. 9(4):1024-1033, 2017. DOI:10.1016/j.stemcr.2017.08.010 - Kimura A, Takemura M, Saito K, Serrero G, Yoshikura N, Hayashi Y, Inuzuka T.
Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder.
J Neuroimmunol. 305:175-181, 2017. DOI:10.1016/j.jneuroim.2017.01.006 - DiRienzo, N. and Aonuma H.
Individual differences are consistent across changes in mating status and mediated by biogenic amine.
Behav. Ecol. Sociobiol. 71:118, 2017. DOI:10.1007/s00265-017-2345-x - Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S.
Iron and thiol redox signaling in cancer.
Free Radical Biology & Medicine 108:610-626, 2017. DOI:10.1016/j.freeradbiomed.2017.04.024 - Fujikawa J., Takeuchi Y. et al.
Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes.
Cell & Tissue Research 370(3):441-449, 2017. DOI:10.1007/s00441-017-2674-0 - Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
Large-scale analysis reveals populational contributions of cortical spike rate and synchrony to behavioral functions.
The Journal of Physiology 595(1):385-413, 2017. DOI:10.1113/JP272794 - Yamashita T, *Yamanaka A
Lateral hypothalamic circuits for sleep-wake control.
Current Opinion in Neurobiology 44:94-100, 2017. DOI:10.1016/j.conb.2017.03.020 - Yamamoto, H., Umeda, D., Matsumoto, S., and Kikuchi, A.
LDL switches the LRP6 internalization route from flotillin dependent to clathrin dependent in hepatic cells.
J. Cell Sci 130:3542-3556, 2017. DOI:10.1242/jcs.202135 - Masukawa D, Koga M, Sezaki A, Ichinose H, Sakurai T, Umemura S, Tamura K, Ishikawa Y, Goshima Y, et al.
L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor.
JCI Insight 2:e90903, 2017. DOI:10.1172/jci.insight.90903 - van Wijk SJL, Fricke F, Herhaus L, Gupta J, H?tte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I.
Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.
Nat Microbiol. 2:17066, 2017. DOI:10.1038/nmicrobiol.2017.66 - Yanagisawa H, Ishii T, Endo K, Kawakami E, Nagao K, Miyashita T, Akiyama K, Watabe K, Komatsu M, Yamamoto D, Eto Y.
L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human Niemann-Pick type C disease.
Sci Rep. 7, 2017. DOI:10.1038/s41598-017-15305-9 - Kondo A, Nonaka A, Shimamura T, Yamamoto S, Yoshida T, Kodama T, Aburatani H and Osawa T
Long non-coding RNA JHDM1D-AS1 promotes tumor growth by regulating angiogenesis in response to nutrient starvation.
Molecular and Cellular Biology 37(18):e00125-17, 2017. - Connor SA, Ammendrup-Johnsen I, Kishimoto Y, Karimi Tari P, Cvetkovska V, Harada T, Ojima D, Yamamoto T, Wang YT, Craig AM.
Loss of Synapse Repressor MDGA1 Enhances Perisomatic Inhibition, Confers Resistance to Network Excitation, and Impairs Cognitive Function.
Cell Rep. 21:3637-3645, 2017. DOI:10.1016/j.celrep.2017.11.109 - Hanaki, Y., Kikumori, M., Tokuda, H., Okamura, M., Dan, S., Adachi, N., Saito, N., Yanagita, R. C., Irie, K.
Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities.
Molecules 22(4):e631, 2017. DOI:10.3390/molecules22040631 - Hashimotodani, Y., Nasrallah, K., Jensen, K.R., Chavez, A.E., Carrera, D., and Castillo, P.E.
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
Neuron 95:928-943, 2017. DOI:10.1016/j.neuron.2017.07.028 - Iizuka-Hishikawa Y, Hishikawa D, Sasaki J, Takubo K, Goto M, Nagata K, Nakanishi H, Shindou H, Okamura T, Ito C, Toshimori K, Sasaki T, Shimizu T.
Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis.
J Biol Chem. 292:12065-12076, 2017. DOI:10.1074/jbc.M117.791277 - Fuse MJ, Okada K, Oh-hara T, Ogura H, Fujita N, *Katayama R.
Mechanisms of resistance to NTRK inhibitors and therapeutic strategies in NTRK1-rearranged cancers.
Molecular Cancer Therapeutics 16:2130-2143, 2017. DOI:10.1158/1535-7163.MCT-16-0909 - Yamamoto K, Mak TW
Mechanistic aspects of mammalian cell size control.
Development Growth and Differentiation 59(1):33-40, 2017. DOI:10.1111/dgd.12334 - Yamamoto S., Hagihara T., Horiuchi H., Okui A., Wani S., Yoshida T., Inoue T., Tanaka A., Ito T., Hirose Y., and Ohkuma Y.
Mediator Cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.
Genes to Cells 22(3):265-276, 2017. DOI:10.1111/gtc.12475 - Yoshida A, Kitajima S, Li F, Cheng C, Takegami Y, Kohno S, Wan YS, Hayashi N, Muranaka H, Nishimoto Y, Nagatani N, Nishiuchi T, Thai TC, Suzuki S, Nakao S, Tanaka T, Hirose O, Barbie DA, Takahashi C.
MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6.
Oncotarget 8(8):13872-13885, 2017. DOI:10.18632/oncotarget.14681 - Tanaka K, Kim SE, Yano H, Matsumoto G, Ohuchida R, Ishikura Y, Araki M, Araki K, Park S, Komatsu T, Hayashi H, Ikematsu K, Tanaka K, Hirano A, Martin P, Shimokawa I, Mori R
MiR-142 Is Required for Staphylococcus aureus Clearance at Skin Wound Sites via Small GTPase-Mediated Regulation of the Neutrophil Actin Cytoskeleton.
J Invest Dermatol 137(4):931-940, 2017. DOI:10.1016/j.jid.2016.11.018 - Shikata Y, Kiga M, Futamura Y, Aono H, Inoue H, Kawada M, Osada H, and Imoto M.
Mitochondrial uncoupler exerts a synthetic lethal effect against beta-catenin mutant tumor cells.
Cancer Science 108:772-784, 2017. DOI:10.1111/cas.13172 - Fumoto, K., Takigawa-Imamura, H., Sumiyama, K., Kaneiwa, T., and Kikuchi, A.
Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition.
Development 144:151-162, 2017. DOI:10.1242/dev.141325 - Mashima T, Taneda Y, Jang MK, Mizutani A, Muramatsu Y, Yoshida H, Sato A, Tanaka N, Sugimoto Y, Seimiya H.
mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer.
Oncotarget 8(29):47902-47915, 2017. DOI:10.18632/oncotarget.18146 - Sashida G, Iwama A.
Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies.
Int J Hematol 105(1):23-30, 2017. DOI:10.1007/s12185-016-2124-x - Takiguchi T, Koide H, Nagano H, Nakayama A, Fujimoto M, Tamura A, Komai E, Shiga A, Kono T, Higuchi S, Sakuma I, Hashimoto N, Suzuki S, Miyabayashi Y, Ishiwatari N, Horiguchi K, Nakatani Y, Yokote K, Tanaka T.
Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
BMC Endocr Disord. 17(1):54-61, 2017. DOI:10.1186/s12902-017-0203-5 - Umeda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, Tomiyama T
Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.
Acta Neuropathol Commun 31:5(1):59, 2017. DOI:10.1186/s40478-017-0461-5 - Asano T, Ishizuka T, Yawo H.
Myogenic Maturation by Optical-Training in Cultured Skeletal Muscle Cells.
Methods Mol Biol. 1668:135-145, 2017. DOI:10.1007/978-1-4939-7283-8_10 - M. Ishido*, J. Suzuki, Y. Masuo
Neonatal rotenone lesions cause onset hyperactivity during juvenile and adulthood in the rat.
Toxicol. Lett. 266:42-48, 2017. DOI:10.1016/j.toxlet.2016.12.008 - Enoki Y, Sato T, Kokabu S, Hayashi N, Iwata T, Yamato M, Usui M, Matsumoto M, Tomoda T, Ariyoshi W, Nishihara T, Yoda T
Netrin-4 Promotes Differentiation and Migration of Osteoblasts.
In vivo 31(5):793-9, 2017. - Ishisaka N, Shimano S, Miura T, Motomura K, Horii M, Imanaga H, Kishimoto J, Kaneda Y, Sora I, Kanba S.
Neurocognitive Profile of Euthymic Japanese Patients With Bipolar Disorder.
Psychiatry Clin Neurosci. 71(6):373-382, 2017. DOI:10.1111/pcn.12500 - Yuji Sato, Satoko Suzuki, Yoko Iijima, and Takatoshi Iijima.
Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of Neurexin in cerebellar cultures.
Biochemical and Biophysical Research Communications. 493:1030-1036, 2017. DOI:10.1038/s41598-017-11319-5 - Nakatsumi H., Matsumoto M., Nakayama KI.
Noncanonical pathway for regulation of CCL2 expression by an mTORC1-FOXK1 axis promotes recruitment of tumor-associated macrophages.
Cell Rep. 21:2471-86, 2017. DOI:10.1016/j.celrep.2017.11.014 - Fukushima H., Shimizu K., Watahiki A., Hoshikawa S., Kosho T., Oba D., Sakano S., Arakaki M., Yamada A., Nagashima K., Okabe K., Fukumoto S., Jimi E., Bigas A., Nakayama KI., Nakayama K., Aoki Y., Wei W., Inuzuka H.
NOTCH2 Hajdu-Cheney mutations escape SCFFBW7-dependent proteolysis to promote osteoporosis.
Mol. Cell 68:645-58.e5, 2017. DOI:10.1016/j.molcel.2017.10.018 - Kim TS, Shin YH, Lee HM, Kim JK, Choe JH, Jang JC, Um S, Jin HS, Komatsu M, Cha GH, Chae HJ, Oh DC, Jo EK.
Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway.
Sci Rep. 7, 2017. DOI:10.1038/s41598-017-03477-3 - Yamaki N, Hishimoto A, Otsuka I, Sasada T, Boku S, Saito T, Yasuda Y, Yamamori H, Ikeda M, Sora I, Iwata N, Hashimoto R
Optimizing Outcomes in Clozapine Rechallenge Following Neutropenia Using Human Leukocyte Antigen Typing: A Case Report.
Psychiatry Clin Neurosci 71(4):289-290, 2017. DOI:10.1111/pcn.12505 - Ozaki M, Sano H, Sato S, Ogura M, Mushiake H, Chiken S, Nakano N, Nambu A
Optogenetic activation of the sensorimotor cortex reveals “local inhibitory and global excitatory” inputs to the basal ganglia.
Cerebral cortex 27:5716-5726, 2017. DOI:10.1093/cercor/bhx234 - Abe K, Yawo H.
Optogenetic conditioning of paradigm and pattern discrimination in the rat somatosensory system.
PLoS One 12(12):e0189439, 2017. DOI:10.1371/journal.pone.0189439 - Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, *Mendelowitz D
Optogenetic identification of hypothalamic orexin neuron projections to paraventricular spinally projecting neurons.
American journal of physiology. Heart and circulatory physiology 312(4):H808-H817, 2017. DOI:10.1152/ajpheart.00572.2016 - M. Ishido*, R.Usu
Orally administered p-nitrotoluene causes hyperactivity, concomitant with gliosis and impairment of tyrosine hydroxylase immunoreactivity in the rat substantia nigra.
Fund. Toxicol. Sci. 4:151-158, 2017. DOI:10.2131/fts.4.151 - Mukai S, Oue N, Oshima T, Imai T, Sekino Y, Honma R, Sakamoto N, Sentani K, Kuniyasu H, Egi H, Tanabe K, Yoshida K, Ohdan H, Yasui W
Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer.
Journal of Pathology 243(1):100-110, 2017. DOI:10.1002/path.4931 - Yokose, J., Okubo-Suzuki, R., Nomoto, M., Ohkawa, N., Nishizono, H., Suzuki, A., Matsuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A.M., Sasahara, M., Kato, F., Inokuchi, K.
Overlapping memory trace indispensable for linking, but not recalling, individual memories.
Science 355(6323):398-403, 2017. DOI:10.1126/science.aal2690 - Nasanbuyan N, Yoshida M, Takayanagi Y, Inutsuka A, Nishimori K, Yamanaka A, *Onaka T.
Oxytocin-Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice.
Endocrinology. 159(2)::763-775, 2017. DOI:10.1210/en.2017-00606 - Nakamura K, Ding L
Parsing Heterogeneous Striatal Activity.
Frontiers in neuroanatomy 0.488194444444444, 2017. DOI:10.3389/fnana.2017.00043 - Sato A, Ogita H.
Pathophysiological Implications of Dipeptidyl Peptidases.
Curr Protein Pept Sci 18:843-849, 2017. DOI:10.2174/1389203718666170329104936 - Yuichiro Yoneoka, Junichi Yoshimura, Masayasu Okada, Yukihiko Fujii:
Perifocal Inflammatory Reaction with Volume Fluctuation Caused by Diagnostic Radiation-Induced Reduction in Germinoma Makes Histological Diagnosis Difficult despite Its Disappearance following Treatment: A Significant Pitfall and Countermeasures to It.
Pediatr Neurosurg. 52:87-92, 2017. DOI:10.1159/000450583 - Naoaki Sakata, Yohko Yamaguchi, Yu Chen, Masayuki Shimoda, Gumpei Yoshimatsu, Michiaki Unno, Shoichiro Sumi, Rieko Ohki.
Pleckstrin homology-like domain family A, member 3 (PHLDA3) deficiency improves islets engraftment through the suppression of hypoxic damage.
PLoS One 12(11):e0187927, 2017. DOI:10.1371/journal.pone.0187927 - Sato N, Shidara H, Ogawa H.
Post-molting development of wind-elicited escape behavior in the cricket.
J Insect Physiol. 103:36-46, 2017. DOI:10.1016/j.jinsphys.2017.10.003 - Fujii K, Luo Y, Nishiguchi Y, Fujiwara R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H
Pro-metastatic intracellular signaling of elaidic acid, a trans fatty acid.
Int J Oncol 50(1):85-92, 2017. DOI:10.3892/ijo.2016.3797 - Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A
Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory-functions and neurogenesis.
Journal of Neurochemistry, 141(1):124-136, 2017. DOI:10.1111/jnc.13963 - Mori S, Kadochi Y, Luo Y, Fujiwara-Tani R, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
Proton pump inhibitor induces-collagen expression in colonocytes is associated with collagenous colitis.
World Journal of Gastroentrology 23(9):1586-1593, 2017. DOI:10.3748/wjg.v23.i9.1586 - Kuramitsu M, Sekizuka T, Yamochi T, Firouzi S, Sato T, Umeki K, Sasaki D, Hasegawa H, Kubota R, Sobata R, Matsumoto C, Kaneko N, Momose H, Araki K, Saito M, Nosaka K, Utsunomiya A, Koh KR, Ogata M, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, Okayama A, Miura K, Satake M, Saito S, Itabashi K, Yamaguchi K, Kuroda M, Watanabe T, Okuma K, Hamaguchi I.
Proviral Features of Human T Cell Leukemia Virus Type 1 in Carriers with Indeterminate Western Blot Analysis Results.
Journal of Clinical Microbiology 55(9):2838-2849, 2017. DOI:10.1128/JCM.00659-17 - Malek M, Kielkowska A, Chessa T, Anderson KE, Barneda D, Pir P, Nakanishi H, Eguchi S, Koizumi A, Sasaki J, Juvin V, Kiselev VY, Niewczas I, Gray A, Valayer A, Spensberger D, Imbert M, Felisbino S, Habuchi T, Beinke S, Cosulich S, Le Nov俊e N, Sasaki T, Clark J, Hawkins PT, Stephens LR.
PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.
Mol Cell 68(3):566-580, 2017. DOI:10.1016/j.molcel.2017.09.024 - Koike M, Shibata M, Sunabori T, Yamaguchi J, Sakimura K, Komatsu M, Tanaka K, Uchiyama Y.
Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.
Am J Pathol. 187:1586-1600, 2017. DOI:10.1016/j.ajpath.2017.02.020 - Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Inoue E, Igeta H, Otsuka I, Shibuya M, Egawa J, Sora I, Someya T.
Rare FBXO18 Variations and Risk of Schizophrenia: Whole-exome Sequencing in Two Parent-Affected Offspring Trios Followed by Resequencing and Case-Control Studies.
Psychiatry Clin Neurosci. 71(8):562-568, 2017. DOI:10.1111/pcn.12526. - Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Kaneko N, Muratake T, Shinmyo N, Otsuka I, Okuda S, Inoue E, Igeta H, Shibuya M, Egawa J, Orime N, Sora I, Someya T.
Rare PDCD11 Variations Are Not Associated With Risk of Schizophrenia in Japan.
Psychiatry Clin Neurosci 71(11):780-788, 2017. DOI:10.1111/pcn.12549 - Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.
Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.
Nucleic Acids Res. 45:435-445, 2017. DOI:10.1093/nar/gkw745 - Moriguchi S, Kita S, Fukaya M, Osanai M, Inagaki R, Sasaki Y, Izumi H, Horie K, Takeda J, Saito T, Sakagami H, Saido TC, Iwamoto T, Fukunaga K
Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.
Neuropharmacology 131:291-303, 2017. DOI:10.1016/j.neuropharm.2017.12.037 - Fukai Y, Ohsawa Y, Ohtsubo H, Nishimatsu S, Hagiwara H, Noda M, Sasaoka T, Murakami T, Sunada Y
Redundancy of matrix metalloproteinases cleaving beta-dystroglycan: Implications for the pathogenesis of sarcoglycanopathy.
Biochemical Biophysical Research Communications 492 (2):199-205, 2017. DOI:10.1016/j.bbrc.2017.08.048 - Katow H, Kanaya T, Ogawa T, Egawa R, Yawo H.
Regulation of axon arborization pattern in the developing chick ciliary ganglion: Possible involvement of caspase 3.
Dev Growth Differ. 59(3):115-128. 2017 59(3):115-128, 2017. DOI:10.1111/dgd.12346 - Kadochi Y, Mori S, Fujiwara-Tani R, Luo Y, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed proliferation of CT26 mouse colon cancer cells.
Oncology Letters 14(1):673-680, 2017. DOI:10.3892/ol.2017.6195 - *Tamada A, Igarashi M
Revealing chiral cell motility by 3D Riesz transform-differential interference contrast microscopy and computational kinematic analysis.
Nature Communications 8:2194ｰ, 2017. DOI:10.1038/s41467-017-02193-w - Kuroda N, Ohe C, Kato I, Furuya M, Baba M, Nagashima Y, Nakatani Y, Murakami I, Zhou M, Michal M, He O, Amin MB
Review of hereditary leiomyomatosis renal cell carcinoma with focus on clinical and pathobiological aspects of renal tumors.
Polish Journal of Pathology 68(4):284-296, 2017. DOI:10.5114/pjp.2017.73920 - Ito S, Koso H, Sakamoto K, Watanabe S
RNA helicase DHX15 acts as a tumour suppressor in glioma.
Br. J. Cancer 117(9):1349-1359, 2017. DOI:10.1038/bjc.2017.273 - K Nakayama, R Ohashi, Y Shinoda, M Yamazaki, M Abe, A Fujikawa, S Shigenobu, A Futatsugi, M Noda, K Mikoshiba, T Furuichi, K Sakimura, and N Shiina
RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation.
eLife 6:e29677, 2017. DOI:10.7554/eLife.29677 - Yachie N., Robotic Biology Consortium (incl. Nakayama KI.), Natsume T.
Robotic crowd biology with Maholo LabDroids.
Nature Biotechnol. 35:310-2, 2017. DOI:10.1038/nbt.3758 - Honda A, Usui H, Sakimura K, *Igarashi M
Rufy3 is an adapter protein for small GTPases that activates a Rac guanine nucleotide exchange factor to control neuronal polarity.
J Biol Chem 292:20936-20946, 2017. DOI:10.1074/jbc.M117.809541 - Wang CQ, Mok MM, Yokomizo T, Tergaonkar V, Osato M.
Runx Family Genes in Tissue Stem Cell Dynamics.
Adv Exp Med Biol 962(-):117-138, 2017. DOI:10.1007/978-981-10-3233-2_9 - Selvarajan V, Osato M, Nah GSS, Yan J, Chung TH, Voon DC, Ito Y, Ham MF, Salto-Tellez M, Shimizu N, Choo SN, Fan S, Chng WJ, Ng SB.
RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC.
Leukemia 31(10):2219-2227, 2017. DOI:10.1038/leu.2017.40 - T. Watanabe, Y. Mutoh, S. Saito
Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylanilides: Synthesis of 3-Substituted Indoles by 1,2-Carbon Migration.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139:7749-7752, 2017. DOI:10.1021/jacs.7b04564 - Kubo H, Hoshi M, Matsumoto T, Irie M, Oura S, Tsutsumi H, Hata Y, Yamamoto Y, Saito K.
Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice.
Lipids Health Dis. 16:106, 2017. DOI:10.1186/s12944-017-0501-y - Sumi-Ichinose C, Suganuma Y, Kano T, Ihira N, Nomura H, Ikemoto K, Hata T, Katoh S, Ichinose H, Kondo K
Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia.
Physiol Rep 5:e13196, 2017. DOI:10.14814/phy2.13196 - Shibata Y, Hara T, Matsumoto T, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Goto N, Nannya Y, Ito H, Kito Y, Miyazaki T, Takeuchi T, Saito K, Seishima M, Takami T, Moriwaki H, Shimizu M, Tsurumi H.
Serum concentrations of l-kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified.
Hematol Oncol 35:637-644, 2017. DOI:10.1002/hon.2318 - Kiyokawa H, Yasuda H, Oikawa R, Okuse C, Matsumoto N, Ikeda H, Watanabe T, Yamamoto H, Itoh F, Otsubo T, Yoshimura T, Yoshida E, Nakagawa M, Koshikawa N & Seiki M
Serum monomeric laminin-gamma2 as a novel biomarker for hepatocellular carcinoma.
Cancer Science 108:1432-1439, 2017. DOI:10.1111/cas.13261 - Nagano H, Nakagawa Y, Ishikawa N, Watanabe Y, Miyabayashi Y, Nakayama A, Fujimoto M, Komai E, Shiga A, Tamura A, Kono T, Takiguchi T, Higuchi S, Sakuma I, Hashimoto N, Suzuki S, Koide H, Yokote K, Tanaka T.
SEVEN FAMILIAL DYSALBUMINEMIC HYPERTHYROXINEMIA CASES IN THREE UNRELATED JAPANESE FAMILIES AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ANALYSIS OF THE THYROXINE BINDING PROFILE.
Endocr Pract 23(11):1325-1332, 2017. DOI:10.4158/EP171964.OR - Yaguchi H., Yabe I., Takahashi H., Watanabe M., Nomura T., Kano T., Matsumoto M., Nakayama KI., Watanabe M., Hatakeyama S.
Sez6l2 regulates phosphorylation of ADD and neuritogenesis.
Biochem. Biophys. Res. Commun. 494:234-41, 2017. DOI:10.1016/j.bbrc.2017.10.047 - Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K
SIRT7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Biochem Biophys Res Commun 490:423-428, 2017. DOI:10.1016/j.bbrc.2017.06.057 - Satoko Suzuki, Noriko Ayukawa, Chisa Okada, Masami Tanaka, Susumu Takekoshi, Yoko Iijima, and Takatoshi Iijima.
Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons.
Scientific Reports 7:11405, 2017. DOI:10.1038/s41598-017-11319-5 - Higuchi T, Ishizaki Y, Noritake A, Yanagimoto Y, Kobayashi H, Nakamura K, Kaneko K.
Spatiotemporal characteristics of gaze of children with autism spectrum disorders while looking at classroom scenes.
PLoS ONE 12(5), 2017. DOI:10.1371/journal.pone.0175912 - Shuji Wakatsuki, Toshiyuki Araki
Specific phospholipid scramblases are involved in exposure of phosphatidylserine, an "eat-me" signal for phagocytes, on degenerating axons.
Commun Integr Biol 17:e1296615, 2017. DOI:10.1080/19420889.2017.1296615 - Ryo Watanabe, Haruki Mizoguchi, Hideaki, Oikawa, Hirofumi Ohashi, Koichi Watashi, HirokiOguri
Stereo-controlled synthesis of functionalized tetrahydropyridines based on the cyanomethylation of 1,6-dihydropyridines and generation of anti-hepatitis C virus agents.
Bioorg. Med. Chem. 25(11):2851-2855, 2017. DOI:10.1016/j.bmc.2017.03.011 - Kimiko Shimizu and Yoshitaka Fukada
Stereotaxic Surgery for Suprachiasmatic Nucleus Lesions in Mice.
Bio-protocol 7:2346, 2017. DOI:10.21769/BioProtoc.2346 - Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H
Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor.
Neuroscience Letters 654:99-106, 2017. DOI:10.1016/j.neulet.2017.06.005 - Yonehara R., Nada S., Nakai T., Nakai M., Kitamura A., Ogawa A., Nakatsumi H., Nakayama KI., Li S., Standley DM., Yamashita E., Nakagawa A., Okada M.
Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nature Commun. 8:1625, 2017. DOI:10.1038/s41467-017-01762-3 - K. Ito, Y. Mutoh, S. Saito
Synthesis of [2]Catenanes by Intramolecular Sonogashira-Type Reaction.
JOURNAL OF ORGANIC CHEMISTRY 82:6188-6124, 2017. DOI:10.1021/acs.joc.7b00672 - Yamazaki, Y.; Mutoh, Y.; Saito, S.
Synthesis of Interlocked Compounds by Utilizing Bond-forming Reactions Mediated by Macrocyclic Phenanthroline-Cu Complexes.
CHEMISTRY LETTERS 46:904-912, 2017. DOI:10.1246/cl.170031 - Y. Mochizuki, K. Ikeyatsu, Y. Mutoh, S. Hosoya, S. Saito
Synthesis of Mechanically Planar Chiral rac-[2]Rotaxanes by Partitioning of an Achiral [2]Rotaxane: Stereoinversion Induced by Shuttling.
ORGANIC LETTERS 19:4347-4350, 2017. DOI:10.1021/acs.orglett.7b02043 - Nakamura T, Okabe S, Yoshida H, Iida K, Ma Y, Sasaki S, Yamori T, Shin-Ya K, Nakano I, Nagasawa K, Seimiya H.
Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole.
Scientific Reports 7:e3605, 2017. DOI:10.1038/s41598-017-03785-8 - Aizawa F, Ogaki Y, Kyoya N, Nakamoto K, Kurihara T, Hirasawa A, Miyata A, Tokuyama S,
The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice.
Biol Pharm Bull 40:1255-1259, 2017. DOI:10.1248/bpb.b17-00082 - Park S, Mori R, Shimokawa I
The fat regulator neuropeptide Y and caloric restriction.
Aging (Albany NY) 9(11):2243-2244, 2017. DOI:10.18632/aging.101338 - Nobuhiko Takai, Masatsugu Ohgami, Koichi Ando, Akiko Uzawa, Ryoichi Hirayama, Saori Nakamura, Yoshihito Ohba
THE FOCAL BRAIN IRRADIATION OF PROTON BEAM INSULT IN RATS INDUCED MEMORY DISTURBANCE RELATED CHANGE IN ACETYLCHOLINE RECEPTOR BINDING.
RadProc vol.2:25-29, 2017. DOI:10.21175 - Mouri A, Noda Y, Niwa M, Matsumoto Y, Mamiya T, Nitta A, Yamada K, Furukawa S, Iwamura T, Nabeshima T.
The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization.
Behav Brain Res. 329:157-165, 2017. DOI:10.1016/j.bbr.2017.04.052 - Yahiro, T., Kataoka, N., Nakamura, Y., Nakamura, K.
The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation.
Scientific Reports 7:5031, 2017. DOI:10.1038/s41598-017-05327-8 - Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I, Wakana S, Yamaguchi M, Shitara H, Taya C, Karaplis AC, Kominami R, and Wakabayashi Y
The parathyroid hormone regulates skin tumour susceptibility in mice.
Scientific Reports 7(1):11208, 2017. DOI:10.1038/s41598-017-11561-x - Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I, Wakana S, Yamaguchi M, Shitara H, Taya C, Karaplis AC, Kominami R, and Wakabayashi Y.
The parathyroid hormone regulates skin tumour susceptibility in mice.
Scientific Reports 7 (1):11208, 2017. - Murakami Y, Fukui R, Motoi Y, Shibata T, Saitoh SI, Sato R, Miyake K.
The Protective Effect of the anti-Toll-like Receptor 9 Antibody Against Acute Cytokine Storm Caused by Immunostimulatory DNA.
Sci Rep 7:44042, 2017. DOI:10.1038/srep44042 - Kake S, Tsuji S, Enjoji S, Hanasaki S, Hayase H, Yabe R, Tanaka Y, Nakagawa T, Liu HP, Chang SC, Usui T, Ohama T*, Sato K
The Role of SET/I2PP2A in canine mammary tumors.
Scientific Reports 27:4279, 2017. DOI:10.1038/s41598-017-04291-7 - Takakura Y, Yamaguchi N, Honda T, Morii M, Yuki R, Nakayama Y, Yamaguchi N
The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALK(ATI)) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner.
Biol Pharm Bull. 40(11):1968-1975, 2017. DOI:10.1248/bpb.b17-00548 - Yuichiro Yoneoka, Junichi Yoshimura, Masakazu Sano, Masayasu Okada, Akiyoshi Kakita, Yukihiko Fujii
Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement.
Pediatr Neurosurg. 53(1):49-54, 2017. DOI:10.1159/000480021 - Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI.
Thymidine Catabolism as a Metabolic Strategy for Cancer Survival.
Cell Reports 19:1313-1321, 2017. DOI:10.1016/j.celrep.2017.04.061 - Ogura H, Nagatake-Kobayashi Y. Adachi J, Tomonaga T, Fujita N, *Katayama R.
TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity.
Scientific Reports 7:5519, 2017. DOI:10.1038/s41598-017-05736-9 - Saitoh S, Abe F, Kanno A, Tanimura N, Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K, and Miyake K
TLR7 Mediated Viral Recognition Results in Focal Type I Interferon Secretion by Dendritic Cells.
Nat. Commun. 8(1):1592, 2017. DOI:10.1038/s41467-017-01687-x - Eisuke Sato, Miho Sato, Yurika Tanabe, Naoya Nakajima, Akifumi Ohkubo, Kiyotake Suenaga
Total Synthesis of Biselyngbyaside.
The Jornal of Organic Cehmistry 82 (13):6770-6777, 2017. DOI:10.1021/acs.joc.7b00905 - Wong-Lin K, Wang DH, Moustafa AA, Cohen JY, Nakamura K.
Toward a multiscale modeling framework for understanding serotonergic function.
Journal of psychopharmacology 31(9):1121-1136, 2017. DOI:10.1177/0269881117699612 - Magi S, Iwamoto K, Yumoto N, Hiroshima M, Nagashima T, Ohki R, Garcia-Munoz A, Volinsky N, Kriegsheim AV, Sako Y, Takahashi K, Kimura S, Kholodenko BN, Okada-Hatakeyama M
Transcriptionally inducible Pleckstrin homology-like domain family A member 1 attenuates ErbB receptor activity by inhibiting receptor oligomerization.
J Biol Chem 293:2206-2218., 2017. DOI:10.1074/jbc.M117.778399 - Nomiyama H, Osada N, Takahashi I, Terao K, Yamagata K, Yoshie O
Translational repression of a splice variant of cynomolgus macaque CKCL1L by its C-terminal sequence.
Journal of Interferon and Cytokine Research 37:129-138, 2017. DOI:10.1089/jir.2016.0085 - Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K*.
Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Exp Neurol 293:1-12, 2017. DOI:10.1016/j.expneurol.2017.03.009 - Kano M, Watanabe T
Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease.
F1000Research 6:416, 2017. DOI:10.12688/f1000research.10485.1 - Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R.
Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.
Cell Res. 27:657-6674, 2017. DOI:10.1038/cr.2017.40 - Oh Y-M, Karube F…Fujiyama F. et al.
Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations.
Brain Struct Funct 222:2359-2378, 2017. DOI:10.1007/s00429-016-1346-2 - Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T.
Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.
JCI Insight 2(1):e89462, 2017. DOI:10.1172/jci.insight.89462 - Honda T, Morii M, Nakayama Y, Suzuki K, Yamaguchi N, Yamaguchi N
v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling.
Sci Rep. 8:1063, 2017. DOI:10.1038/s41598-018-19599-1 - Aonuma H., Kaneda M., Hatakeyama D., Watanabe T., Lukowiak K. and Ito E.
Weak involvement of octopamine in aversive taste learning in a snail.
Neurobiol. Learn. Mem. 141:189-198, 2017. DOI:10.1016/j.nlm.2017.04.010 - 斎藤慎一， 片村友大， 武藤雄一郎
アジリジン，アゼチジンの環拡大反応を利用したN-ヘテロ環合成法の開発.
有機合成化学協会誌 75:340-348, 2017. DOI:10.5059/yukigoseikyokaishi.75.340 - 山中章弘
オレキシン神経活動操作による機能解明.
睡眠医療 11(1):19-25, 2017. - 設樂久志，小川宏人
コオロギの音源定位ナビゲーション－神経行動学が迫る動物のナビゲーションメカニズム.
生物の科学 遺伝 71:519-525, 2017. - Iijima J, Kobayashi S, Kitazume S, Kizuka Y, Fujinawa R, Korekane H, Shibata T, Saitoh SI, Akashi-Takamura S, Miyake K, Miyoshi E, Taniguchi N.
タンパク質におけるフコース修飾の意義の解析.
Glycobiology 27(11):1006-1015, 2017. DOI:10.1093/glycob/cwx075 - Sato R*, Shibata T*, Tanaka Y, Kato C, Yamaguchi K, Furukawa Y, Shimizu E, Yamaguchi R, Imoto S, Miyano S, Miyake K. (* equally contributed)
ノックアウトライブラリーを用いた分子探索.
Int Immunol 29(8):347-355, 2017. DOI:10.1093/intimm/dxx044 - 河原康一、古川龍彦
核小体によるp53制御とがん治療薬開発の新展開.
実験医学 35:2365-2367, 2017. - 山中章弘
光遺伝学による神経科学研究の新展開.
医学のあゆみ 262(5):491-495, 2017. - 山中章弘
光遺伝学による睡眠覚醒の制御.
生体の科学 65(5):484-485, 2017. - Otsuka I, Izumi T, Boku S, Kimura A, Zhang Y, Mouri K, Okazaki S, Shiroiwa K, Takahashi M, Ueno Y, Shirakawa O, Sora I, Hishimoto A.
自殺既遂者におけるテロメア長とミトコンドリアDNAコピー数の研究.
Sci Rep. 7(1):31-76, 2017. - 山中章弘
睡眠のマニピュレーション-光遺伝学、薬理遺伝学を用いた睡眠覚醒の操作.
医学のあゆみ 263(9):765-774, 2017. - Wu MK, Takemoto M, Taniguchi M, Takumi T, Okazaki T, Song W-J.
Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1.
American Journal of Physiology-Cell Physiology 311(1):C15-23, 2016. DOI:10.1152/ajpcell.00272.2015 - 岡田正康
軸索再生に対するGAP-43の機能解明:GAP-43 (Ser96)のリン酸化は軸索再生の分子マーカーとなる.
新潟医学会雑誌 130(7):405-419, 2016. - Katsutoshi Imamura, Akiko Takaya, Yo-ichi Ishida, Yayoi Fukuoka, Toshiki Taya, Ryo Nakaki, Miho Kakeda, Naoto Imamachi, Aiko Sato, Toshimichi Yamada, Yutaka Suzuki, Masami Nagahama, Tomoko Yamamot, Torben Heick Jensen, Nobuyoshi Akimitsu
Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs.
EMBO Journal
2016年度
- Hiroshi Fukamachi, Seon-Kyu Kim, Jiwon Koh, Hye Seung Lee, Yasushi Sasaki, Kentaro Yamashita, Taketo Nishikawaji, Shu Shimada, Yoshimitsu Akiyama, Sun-ju Byeon, Dong-Hyuck Bae, Keisuke Okuno, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Hiroshi Kawachi, Kiichiro Tsuchiya, Kazuyuki Kojima, Takashi Tokino, Yoshinobu Eishi, Yong Sung Kim, Woo Ho Kim, Yasuhito Yuasa, and Shinji Tanaka
A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors.
Journal of Experimental & Clinical Cancer Research 38:127, 2019. DOI:10.1186/s13046-019-1121-3 - Kanetake T, Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, Kihara A
Neural symptoms in a gene knockout mouse model of Sj?gren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide.
FASEB Journal 33:928-941, 2019. DOI:10.1096/fj.201800291R - Kasahara Y, Sakakibara Y, Hiratsuka T, Moriya Y, Lesch KP, Hall FS, Uhl GR, Sora I
Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice.
Neuropsychopharmacology Reports 39:130-133, 2019. DOI:10.1002/npr2.12049 - Kano T., Sato E., Ono T., Aonuma H., Matsuzaka Y. and Ishiguro A.
A brittle star-like robot capable of immediately adapting to unexpected physical damage.
Royal Soc. Open Sci. 4:171200, 2018. DOI:10.1098/rsos.171200 - Sumitani M, Nishizawa D, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain.
Pain Medicine 19:348-354, 2018. DOI:10.1093/pm/pnx102 - DiRienzo, N. and Aonuma H.
Plasticity in extended phenotype increases offspring defense despite individual variation in web structure and behavior.
Animal Behav. 138:9ｰ17, 2018. DOI:10.1016/j.anbehav.2018.01.022 - Kai Kitamura, Hiroaki Itoh, Kaori Sakurai, Shingo Dan, Masayuki Inoue
Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase.
Journal of the American Chemical Society 140(38):12189-12199, 2018. DOI:10.1021/jacs.8b07339 - Motohiro Nozumi, Michihiro Igarashi
Vesicular movements in the growth cone.
Neurochemistry International 119:71-76, 2018. DOI:10.1016/j.neuint.2017.09.011 - Shiratori C., Suzuki N., Momohara Y., Shiraishi K., Aonuma H., and Nagayama T.
Cyclic AMP-regulated opposing and parallel effects of serotonin and dopamine on phototaxis in the Marmorkrebs (marbled crayfish).
Europ. J. Neurosci. 46:1863-1874, 2017. DOI:10.1111/ejn.13632 - Saito T, Ishii A, Sugai K, Sasaki M, Hirose S.
A de novo missense mutation in SLC12A5 found in a compound heterozygote patient with epilepsy of infancy with migrating focal seizures.
Clinical Genetics 92(6):654-658, 2017. DOI:10.1111/cge.13049 - Matsumoto M., Matsuzaki F., Oshikawa K., Goshima N., Mori M., Kawamura Y., Ogawa K., Fukuda E., Nakatsumi H., Natsume T., Fukui K., Horimoto K., Nagashima T., Funayama R., Nakayama K. & Nakayama KI.
A large-scale targeted proteomics assay resource based on an in vitro human proteome.
Nature Methods 14:251-8, 2017. DOI:10.1038/nmeth.4116 - Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, *Komatsu M.
A novel approach to assess the ubiquitin-fold modifier 1-system in cells.
FEBS Lett. 591:196-204, 2017. DOI:10.1002/1873-3468.12518 - Uchida T, Lossin C, Ihara Y, Deshimaru M, Yanagawa Y, Koyama S, Hirose S.
Abnormal gamma-aminobutyric acid neurotransmission in a Kcnq2 model of early onset epilepsy.
Epilepsia 58(8):1430-1439, 2017. DOI:10.1111/epi.13807 - Ayumi Hashimoto, Toyohiro Sawada, Itsuki Kageyama, Kiyohisa Natsume
Activation of the muscarinic receptors induces the transition of the epileptic discharges to beta oscillation in hippocampal slices.
Biophysics_and Physicobiology 14:137-146, 2017. DOI:10.2142/biophysico.14.0_137 - *Ueno T, *Komatsu M.
Autophagy in the liver: functions in health and disease.
Nat Rev Gastroenterol Hepatol. 14:170-184, 2017. DOI:10.1038/nrgastro.2016.185 - Uchibori K, Inase N, Araki M, Kamada M, Sato S, Okuno Y, Fujita N, *Katayama R.
Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer.
Nature communications 8:14768, 2017. DOI:10.1038/ncomms14768 - Sho Wakayama, Shigeki Kiyonaka, Itaru Arai, Wataru Kakegawa, Shinji Matsuda, Keiji Ibata, Yuri L. Nemoto, Akihiro Kusumi, Michisuke Yuzaki & Itaru Hamachi
Chemical labeling for visualizing native AMPA receptors in live neurons.
Nature Communications 8:e14850, 2017. DOI:10.1038/ncomms14850 - Ishii A, Watkins JC, Chen D, Hirose S, Hammer MF.
Clinical implications of SCN1A missense and truncation variants in a large Japanese cohort with Dravet syndrome.
Epilepsia 58(2):282-290, 2017. DOI:10.1111/epi.13639 - Jun Nakayama, Emi Ito, Jiro Fujimoto, Shinya Watanabe and Kentaro Semba
Comparative analysis of gene regulatory networks of highly metastatic breast cancer cells established by orthotopic transplantation and intra-circulation injection.
International Journal of Oncology 50.2:497-504, 2017. DOI:10.3892/ijo.2016.3809 - Nozumi M, Nakatsu F, Katoh K, *Igarashi M
Coordinated movement of vesicles and actin bundles during nerve growth revealed by superresolution microscopy.
Cell Rep 18:2203-2216, 2017. DOI:10.1016/j.celrep.2017.02.008 - Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.
J Clin Endocrinol Metab 101(3):841-6, 2017. DOI:10.1210/jc.2015-2855 - Goto E, Tokunaga F.
Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.
Biochemical and Biophysical Research Communications 485(1):152-159, 2017. DOI:10.1016/j.bbrc.2017.02.040 - Gen Shiihashi, Daisuke Ito, Itaru Arai, Yuki Kobayashi, Kanehiro Hayashi, Shintaro Otsuka, Kazunori Nakajima, Michisuke Yuzaki, Shigeyoshi Itohara, Norihiro Suzuki
Dendritic homeostasis disruption in a novel frontotemporal dementia mouse model expressing cytoplasmic fused in sarcoma.
EBioMedicine 24:102-115, 2017. DOI:10.1016/j.ebiom.2017.09.005 - Kanki, Y., Nakaki, R., Shimamura, T., Matsunaga, T., Yamamizu, K., Katayama, S., Suehiro, J.I., Osawa, T., Aburatani, H., Kodama, , and Minami, T
Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation.
Nuc.Acids.Res 2017 45:4344-58, 2017. - Furuya M, Hasumi H, Baba M, Tanaka R, Iribe Y, Onishi T, Nagashima Y, Nakatani Y, Isono Y, Yao M
Establishment and characterization of BHD-F59RSVT, an immortalized cell line derived from a renal cell carcinoma in a patient with Birt-Hogg-Dub? syndrome.
Laboratory Investigation 97(3):343-351, 2017. DOI:10.1038/labinvest.2016.137 - Honda A, Ito Y, Takahashi-Niki K, Matsushita N, Nozumi M, Tabata H, Takeuchi K, *Igarashi M
Extracellular signals induce glycoprotein M6a clustering of lipid rafts and associated signaling molecules.
J Neurosci 37:4046-4064, 2017. DOI:10.1523/JNEUROSCI.3319-16.2017 - Yamauchi T., Nishiyama M., Moroishi T., Kawamura A., Nakayama KI.
FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem-progenitor cells.
Mol. Cell. Biol. 37:e00470-16, 2017. DOI:10.1128/MCB.00470-16 - Tanabe K, Shinsato Y, Furukawa T, Kita Y, Hatanaka K, Minami K, Kawahara K, Yamamoto M, Baba K, Mori S, Uchikado Y, Maemura K, Tanimoto A, Natsugoe S
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
Oncotarget 8:6353-6363, 2017. DOI:10.18632/oncotarget.14087 - Kayama K., Watanabe S., Takafuji T., Tsuji T., Hironaka K., Matsumoto M., Nakayama KI., Enari M., Kohno T., Shiraishi K., Kiyono T., Yoshida K., Sugimoto N., Fujita M.
GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
EMBO Rep. 18:123-37, 2017. DOI:10.15252/embr.201642444 - Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue J.
HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.
PLoS Pathogens 13:e100162, 2017. DOI:10.1371/journal.ppat.1006162 - Jinshu Xu, Ueno H,Chelsea Xu, Binglai Chen, Irving Weissman, and Pin-Xian Xu.
Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti.
Nature Communications 8, 15046, 2017. DOI:10.1038/ncomms15046 - Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y.
Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice.
Gastroenterology 152(1):218-231.e14, 2017. DOI:10.1053/j.gastro.2016.09.018 - T. Hara, T. Kojima, H. Matsuzaki, T. Nakamura, E. Yoshida, Y. Fujiwara, C. Yamamoto, S. Saito, T. Kaji
Induction of Syndecan-4 by Organic-Inorganic Hybrid Molecules with a 1,10-Phenanthroline Structure in Cultured Vascular Endothelial Cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18:352, 2017. DOI:10.3390/ijms18020352 - Numata T, Tsumoto K, Yamada K, Kurokawa T, Hirose S, Nomura H, Kawano M, Kurachi Y, Inoue R, Mori Y.
Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing.
Scientific Reports 7(1):9760, 2017. DOI:10.1038/s41598-017-10357-3 - Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Saiga K, Ohsugi H, Tokuyama Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M, and Ueno H.
Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion.
Scientific Reports 7, 41838, 2017. DOI:10.1038/srep41838 - Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Saiga K, Ohsugi H, Tokuyama Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M, and Ueno H.
Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity.
Scientific Reports 7, 9891, 2017. DOI:10.1038/s41598-017-09927-2 - Jin M, Pomp O, Shinoda T, Toba S, Torisawa T, Furuta K, Oiwa K, Yasunaga T, Kitagawa D, Matsumura S, Miyata T, Tan TT, Reversade B, Hirotsune S.
Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.
Sci Rep. 7:e39902, 2017. DOI:10.1038/srep39902 - Zamani A, Sakuragi S, Ishizuka T, Yawo H.
Kinetic characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization.
Biophys Physicobiol. 14:13-22, 2017. DOI:10.2142/biophysico.14.0_13 - Jin Cui, Maho Morita, Osamu Ohno, Tomoyuki Kimura, Toshiaki Teruya, Takumi Watanabe, Kiyotake Suenaga, and Masakatsu Shibasaki:
Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis.
Chemistry An Eurean Journal 23 (35):8500-8509, 2017. DOI:10.1002/chem.201701183 - Nakamura, Y., Yanagawa, Y., Morrison, S.F., Nakamura, K.
Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication.
Cell Metabolism 25:322?334, 2017. DOI:10.1016/j.cmet.2016.12.002 - Matsumoto A., Pasut A., Matsumoto M., Yamashita R., Fung J., Saghatelian A., Nakayama KI., Clohessy JG., Monteleone E., Pandolfi PP.
mTORC1 and muscle regeneration are regulated by the LINC00961 encoded SPAR polypeptide.
Nature 541:228-32, 2017. DOI:10.1038/nature21034 - Hayashi K, Katanosaka K, Abe M, Yamanaka A, Nosaka K, Mizumura K, *Taguchi T
Muscular mechanical hyperalgesia after lengthening contractions in rats depends on stretch velocity and range of motion.
European Journal of Pain 21(1):125-139, 2017. DOI:10.1002/ejp.909 - Misako Matsushita, Yuhki Nakatake, Itaru Arai, Keiji Ibata, Kazuhisa Kohda, Sravan Goparaju, Miyako Murakami, Miki Sakota, Nana Chikazawa-Nohtomi, Shigeru Ko, Takanori Kanai, Michisuke Yuzaki & Minoru S.H. Ko
Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors.
Biochemical and Biophysical Research Communications 490:296-301, 2017. DOI:10.1016/j.bbrc.2017.06.039 - Ishii A, Hirose S.
New Genes for Epilepsy - Autism Comorbidity.
Journal of Pediatric Neurology 15(3):105-114, 2017. DOI:10.1055/s-0037-1602822 - Matsuzaka Y, Sato E., Kano T., Aonuma H. and Ishiguro A.
Non-centralized and functionally localized nervous system of ophiuroids: evidence from topical anesthetic experiments.
Biology Open 6:425-438, 2017. DOI:10.1242/bio.019836 - Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Ueno H, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, and Kuo CJ.
Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.
Nature 545:238-242, 2017. DOI:10.1038/nature22313 - Sasaki M, Ishii A, Saito Y, Hirose S.
Progressive Brain Atrophy in Alternating Hemiplegia of Childhood.
Movement Disorders Clinical Practice 4(3):406-411, 2017. DOI:10.1002/mdc3.12451 - Furuse T., Miyake K., Kohda T., Kaneda H., Hirasawa T., Yamada I., Kushida T., Kashimura M., Kobayashi K., Ishino F., Kubota T., Wakana S.
Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny.
Genes & Nutrition , 2017. DOI:10.1186/s12263-016-0550-2 - Hammer MF, Ishii A, Johnstone L, Tchourbanov A, Lau B, Sprissler R, Hallmark B, Zhang M, Zhou J, Watkins J, Hirose S.
Rare variants of small effect size in neuronal excitability genes influence clinical outcome in Japanese cases of SCN1A truncation-positive Dravet syndrome.
PLoS ONE 12(7):e0180485, 2017. DOI:10.1371/journal.pone.0180485 - Morinaga T, Yanase S, Okamoto A, Yamaguchi N, Yamaguchi N
Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells.
Sci Rep. 7:493, 2017. DOI:10.1038/s41598-017-00538-5 - Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H.
Reduced SHARPIN and LUBAC formation may contribute to CCl4- or acetaminophen-induced liver cirrhosis in mice.
International Journal of Molecular Sciences 18:326, 2017. DOI:10.3390/ijms18020326 - Morii M, Kubota S, Honda T, Yuki R, Morinaga T, Kuga T, Tomonaga T, Yamaguchi N, Yamaguchi N
Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530.
J Biol Chem. 292(5):1648-1665, 2017. DOI:10.1074/jbc.M116.753202 - Ohnishi T., Shirane M., Nakayama KI.
SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth.
Sci. Rep. 7:41130, 2017. DOI:10.1038/srep41130 - T. Fukuda, T. Katae, I. Harada, M. Iwao
Synthesis of Lamellarins via Regioselective Assembly of 1,2-Diarylated [1]Benzopyrano[3,4-b]pyrrol-4(3H)-one Core.
Heterocycles 95 (2):950-971, 2017. DOI:10.3987/COM-16-S(S)63 - Katamura, T.; Shimizu, T.; Mutoh, Y.; Saito, S.
Synthesis of Tricyclic Benzazocines by Aza-Prins Reaction.
Organic Letters 19(1):266-269, 2017. DOI:10.1021/acs.orglett.6b03577 - Hanaya R, Niantiarno FH, Kashida Y, Hosoyama H, Maruyama S, Otsubo T, Tanaka K, Ishii A, Hirose S, Arita K.
Vagus nerve stimulation for genetic epilepsy with febrile seizures plus (GEFS+) accompanying seizures with impaired consciousness.
Epilepsy & Behavior Case Reports 7:16-19, 2017. DOI:10.1016/j.ebcr.2016.11.001 - 山中章弘
睡眠覚醒調節におけるオレキシンの役割.
医薬ジャーナル 53(2):97-100, 2017. - 辻敬一郎・井口善生
動物心理学研究における還元・比較・発生―研究遍歴をめぐる対談をふまえて―.
動物心理学研究 67:73-78, 2017. DOI:10.2502/janip.67.2.1 - Ohta S, Yaguchi T, Okuno H, Chneiweiss H, Kawakami Y, Okano H
CHD7 promotes proliferation of neural stem cells mediated by MIF.
Molecular Brain 9(1):96, 2016. DOI:10.1186/s13041-016-0275-6 - Etsu Tashiro, Shizuka, Henmi, Hiroyuki Odake, Seitaro Ino, Masaya Imoto
Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation.
Biochem Biophys Res Commun 477:801-806, 2016. DOI:10.1016/j.bbrc.2016.06.138 - Muramatsu, M. and Minami, T
Oncogenic combined calcineurin-NFAT and TLR signals in colon.
Trans.Cancer.Res 2016 5, 2016. - Sakata K, Araki K, Nakano H, Nishina T, Komazawa-Sakon S, Murai S, Lee GE, Hashimoto D, Suzuki C, Uchiyama Y, Notohara K, Gukovskaya AS, Gukovsky I, Yamamura KI, Baba H, Ohmuraya M.
Novel Method to Rescue a Lethal Phenotype Through Integration of Target Gene Onto the X-chromosome.
Sci Rep. 6:37200, 2016. DOI:10.1038/srep37200 - Hoque MR, Ishizuka T, Inoue K, Abe-Yoshizumi R, Igarashi H, Mishima T, Kandori H, Yawo H.
A Chimera Na+-Pump Rhodopsin as an Effective Optogenetic Silencer.
PLoS One. 11(11):e0166820, 2016. DOI:10.1371/journal.pone.0166820 - Ishii A, Kang JQ, Schornak CC, Hernandez CC, Shen W, Watkins JC, Macdonald RL, Hirose S.
A de novo missense mutation of GABRB2 causes early myoclonic encephalopathy.
Journal of Medical Genetics 54(3):202-211, 2016. DOI:10.1136/jmedgenet-2016-104083 - Igarashi H, Koizumi K, Kaneko R, Ikeda K, Egawa R, Yanagawa Y, Muramatsu S, Onimaru H, Ishizuka T, Yawo H.
A Novel Reporter Rat Strain That Conditionally Expresses the Bright Red Fluorescent Protein tdTomato.
PLoS One. 11(5):e0155687, 2016. DOI:10.1371/journal.pone.0155687 - Ayumi Suzuki, Takahiro Arai, Kota Ikenaga, Yuichiro Mutoh, Noriko Tsuchida, Scinchi Saito, Youichi Ishii
A ruthenium tellurocarbonyl (CTe) complex with a cyclopentadienyl ligand: Systematic studies of a series of the chalcogenocarbonyl complexes [CpRuCl(CE)(H2IMes)] (E = O, S, Se, Te).
DALTON TRANSACTIONS 46:44 - 48, 2016. DOI:10.1039/C6DT04440A - Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T, Yamaoka S.
A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.
Leukemia 30(3):716-727, 2016. DOI:10.1038/leu.2015.267 - Ohta H, Kohno Y, Arake M, Tamura R, Yukawa S, Sato Y, Morimoto Y, Nishida Y, Yawo H.
Adrenergic receptor-mediated modulation of striatal firing patterns.
Neurosci Res. 112:47-56, 2016. DOI:10.1016/j.neures.2016.05.004 - Hosokawa H., Tanaka T., Endo Y., Kato M., Shinoda K., Suzuki A., Motohashi S., Matsumoto M., Nakayama KI., Nakayama T.
Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.
Nature Commun. 7:11289, 2016. DOI:10.1038/ncomms11289 - Connor SA, Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Kurihara N, Tada A, Ge Y, Lu H, Yan R, LeDue JM, Matsumoto M, Kiyonari H, Kirino Y, Matsuzaki F, Suzuki T, Murphy TH, Wang YT, Yamamoto T, Craig AM
Altered cortical dynamics and cognitive function upon haploinsufficiency of the autism linked excitatory synaptic suppressor MDGA2.
Neuron 91:1052-1068, 2016. DOI:10.1016/j.neuron.2016.08.016 - Yamashita-Sugahara Y, Matsumoto M, Ohtaka M, Nishimura K, Nakanishi M, Mitani K, Okazaki Y
An inhibitor of Fibroblast Growth Factor Receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors.
Scientific Rep. 6:335908, 2016. DOI:10.1038/srep35908 - Nishino T, Matsunaga R, Jikihara H, Uchida M, Maeda A, Qi G, Abe T, Kiyonari H, Tashiro S, Inagaki-Ohara K, Shimamoto F, Konishi H.
Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.
Biochim Biophys Acta. 1861:1816-1827, 2016. DOI:10.1016/j.bbalip.2016.09.006 - Saito S, Fujimaki T, Panbangred W, Igarashi Y and Imoto M
Antarlides, A new-type of Androgen Receptor (AR) Antagonist, that overcomes resistance to AR-targeted Therapy.
Angewandte Chemie Int. Ed. 55:2728-2732, 2016. DOI:10.1002/anie.201510079 - Moinuddin FM, Shinsato Y, Komatsu M, Mitsuo R, Minami K, Yamamoto M, Kawahara K, Hirano H, Arita K, Furukawa T
ATP7B expression confers multidrug resistance through drug sequestration.
Oncotarget 7:22779-90, 2016. DOI:10.18632/oncotarget.8059 - Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A.
Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.
Elife 5, 2016. DOI:10.7554/eLife.14810 - Muona, M., *Lehesjoki, AE., *Komatsu, M (28人中28番目).
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.
Am. J. Hum. Genet 99:683-694, 2016. DOI:10.1016/j.ajhg.2016.06.020 - Tanaka T, Atsumi N, Nakamura N, Yanai H, Komai Y, Omachi T, Tanaka K, Saiga K, Ohsugi H, Tokuyama Y, Hisha H, Yoshida N, Kumano K, Okazaki K, and Ueno H.
Bmi1-positive cells in the lingual epithelium could serve as cancer stem cells in tongue cancer.
Scientific Reports 6, 39386, 2016. DOI:10.1038/srep39386 - Tuboly E, Futakuchi M, Varga G, Erces D, Tokes T, Meszaros A, Kaszaki J, Suzui M, Imai M, Okada A, Okada N, Boros M, Okada H
C5a inhibitor protects ischemia/reperfusion injury in rat small intestine.
Microbiol Immunol 60(1):35-46, 2016. DOI:10.1111/1348-0421 - Mehanna S, Suzuki C, Shibata M, Sunabori T, Imanaka T, Araki K, Yamamura K, Uchiyama Y,?Ohmuraya?M
Cathepsin D in Pancreatic Acinar Cells Is Implicated in Cathepsin B and L Degradation, but Not in Autophagic Activity.
Biochem Biophys Res Commun 469（9）:405-411, 2016. DOI:10.1016/j.bbrc.2015.12.002 - Nomoto, M., Ohkawa, N., Nishizono, H., Yokose, J., Suzuki, A., Matuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A.M., Kato, F., Inokuchi, K.
Cellular tagging as a neural network mechanism for behavioral tagging.
Nature Communications 7:12319, 2016. DOI:10.1038/ncomms12319 - Hiroshi Yamada , Hitoshi Inokawa , Yukiko Hori , Xiaochuan Pan , Ryuichi Matsuzaki , Kae Nakamura , Kazuyuki Samejima , Munetaka Shidara d, Minoru Kimura , Masamichi Sakagami , Takafumi Minamimoto
Characteristics of fast-spiking neurons in the striatum of behaving monkeys.
Neuroscience research 105:2-18, 2016. DOI:10.1016/j.neures.2015.10.003 - Motojima M, Tanimoto S, Ohtsuka M, Matsusaka T, Kume T, Abe K
Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2.
Cells Tissues Organs 201:380-389, 2016. DOI:10.1159/000445027 - Katayama Y., Nishiyama M., Shoji H., Ohkawa Y., Kawamura A., Sato T., Suyama M., Takumi T., Miyakawa T., Nakayama KI.
CHD8 haploinsufficiency results in autistic-like phenotypes in mice.
Nature 537:675-9, 2016. DOI:10.1038/nature19357 - Yan M, Audet-Walsh ?, Manteghi S, Rosa Dufour C, Walker B, Baba M, St-Pierre J, Gigu?re V, Pause A
Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.
Genes & Development 30(9):1034-1046, 2016. DOI:10.1101/gad.281410.116 - Kimura, H., Fumoto, K., Shojima, K., Nojima, S., Osugi, Y., Tomihara, H., Eguchi, H., Shintani, Y., Endo, E., Inoue, M., Doki, Y., Okumura, M., Morii, E., and Kikuchi, A
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression.
J Clin. Invest. 126(7):2689-2705, 2016. DOI:10.1172/JCI84658 - Motojima M, Ogiwara S, Matsusaka T, Kim SY, Sagawa N, Abe K, Ohtsuka M.
Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system.
Mammalian genoem 27:62-69, 2016. DOI:10.1007/s00335-015-9610-y - Koso H, Tsuhako A, Lai CY, Baba Y, Otsu M, Ueno K, Nagasaki M, Suzuki Y, Watanabe
Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina.
Glia 64(11):2005-2024, 2016. DOI:10.1002/glia.23038 - Matsumoto N, Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, Siomi MC, Nureki O.
Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA.
Cell 167:484-497, 2016. DOI:10.1016/j.cell.2016.09.002 - Jayapal SR, Ang HY, Wang CQ, Bisteau X, Caldez MJ, Xuan GX, Yu W, Tergaonkar V, Osato M, Lim B, Kaldis P.
Cyclin A2 regulates erythrocyte morphology and numbers.
Cell Cycle 15(22):3070-3081, 2016. DOI:10.1080/15384101.2016.1234546 - T. Hara, H. Matsuzaki, T. Nakamura, E. Yoshida, T. Ohkubo, H. Maruyama, C. Yamamoto, S. Saito, T. Kaji
Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells.
Fundamental Toxicological Sciences 3:109 - 113, 2016. DOI:10.2131/fts.3.109 - Saito A, Taniguchi Y, Kim SH, Selvakumar B, Perez G, Ballinger MD, Zhu X, Sabra J, Jallow M, Yan P, Ito K, Rajendran S, Hirotsune S, Wynshaw-Boris A, Snyder SH, Sawa A, Kamiya A.
Developmental Alcohol Exposure Impairs Activity-Dependent S-Nitrosylation of NDEL1 for Neuronal Maturation.
Cereb Cortex. 27:3918-3929., 2016. DOI:10.1093/cercor/bhw201 - *Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D
Direct Projections from Hypothalamic Orexin Neurons to Brainstem Cardiac Vagal Neurons.
Neuroscience 339:47-53, 2016. DOI:10.1016/j.neuroscience.2016.09.038 - Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, Kihara A
Disruption of the Sj?gren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
Journal of Biological Chemistry 291(22):11676-11688, 2016. DOI:10.1074/jbc.M116.714030 - Hengguang Zhao, Rieger S, Abe K, Hewison M, Lisse T.
DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization.
Int. J. Mol. Sci. 17:1984, 2016. DOI:10.3390/ijms17121984 - Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T.
Dopamine D2L receptor is required for visual discrimination learning.
Molecular Neuropsychiatry 2 (3):124-132, 2016. DOI:10.1159/000447970 - 山中章弘
DREADD による神経活動操作と精神医学研究.
分子精神医学 16(3):45(189)-47(191), 2016. - Tsuji, M., Takahashi, Y., Watabe, A.M., Kato, F.
Enhanced long-term potentiation in mature rats with a history of cryptogenic infantile spasms.
Epilepsia 57(3):495-505, 2016. DOI:10.1111/epi.13315 - Fujii, S., Shinjo, K., Matsumoto, S., Harada, T., Nojima, S., Sato, S., Usami, Y., Toyosawa, S., Morii, E., Kondo, Y., and Kikuchi, A
Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3'-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma.
Oncotarget 7:81571-81587, 2016. DOI:10.18632/oncotarget.13147 - Kikuta S, Ynagawa Y, Homma N, Osanai M
Evaluation of the amount of the manganese entry in the neurons for activity-induced manganese-enhanced MRI.
Electronics and Communications in Japan 99(8):48-53, 2016. DOI:10.1002/ecj.11838 - Adachi T, Hayashi T
Evolutionarily conserved phosphorylation and palmitoylation-dependent regulation of dopamine D1-like receptors in vertebrates.
Neurotransmitter 3:e1434, 2016. DOI:10.14800/nt.1434 - Pei W Tanaka K, Huang SC, Xu L, Liu B, Sinclair J, Idol J, Varshney GK, Huang H, Lin S, Nussenblatt RB, Mori R, Burgess SM
Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation.
NPJ Regen Med 1:16013, 2016. DOI:10.1038/npjregenmed.2016.13 - Lee DH, Han DH, Nam KT, Park JS, Kim SH, Lee M, Kim G, Min BS, Cha BS, Lee YS, Sung SH, Jeong H, Ji HW, Lee MJ, Lee JS, Lee HY, Chun Y, Kim J, Komatsu M, Lee YH, Bae SH.
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
Free Radic Biol Med. 99:520-532, 2016. DOI:10.1016/j.freeradbiomed.2016.09.009 - Horigane S*, Ageta-Ishihara N*(*共同筆頭著者), Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S, Bito H.
Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKI? pathway during neuronal polarization.
Molecular brain 9(1):8, 2016. DOI:10.1186/s13041-016-0189-3 - Nomir AG., Takeuchi Y. et al.
Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1-Cre mice.
Genesis 54(7):379-388, 2016. DOI:10.1002/dvg.22951 - Nita A., Nishiyama M., Muto Y., Nakayama KI.
FBXL12 regulates T cell differentiation in a cell-autonomous manner.
Genes Cells 5:517-24, 2016. DOI:10.1111/gtc.12360 - Kitade S., Onoyama I., Kobayashi H., Yagi H., Yoshida S., Kato M., Tsunematsu R., Asanoma K., Sonoda K., Wake N., Hata K., Nakayama KI., Kato K.
FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors.
Cancer Sci. 107:1399-405, 2016. DOI:10.1111/cas.13026 - Hadano S, Mitsui S, Pan L, Otomo A, Kubo M, Sato K, Ono S, Onodera W, Abe K, Chen X, Koike M, Uchiyama Y, Aoki M, Warabi E, Yamamoto M, Ishii T, Yanagawa T, Shang H-F, Yoshii F.
Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.
Human Molecular Genetics 25:25, 2016. DOI:10.1093/hmg/ddw180 - Okamoto M, Nakayama Y, Kakihana A, Yuki R, Yamaguchi N, Yamaguchi N
Fyn Accelerates M Phase Progression by Promoting the Assembly of Mitotic Spindle Microtubules.
J Cell Biochem. 117(4):610-623, 2016. DOI:10.1002/jcb.25373 - Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M.
Generation of a new model rat: Nrf2 knockout rats are sensitive to aflatoxin B1 toxicity.
Toxicol Sci 152:40-52, 2016. DOI:10.1093/toxsci/kfw065 - Ishikawa T, Imamura K, Kondo T, Koshiba Y, Hara S, Ichinose H, Furujo M, Kinoshita M, Oeda T, Takahashi J, Takahashi R, Inoue H
Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders.
Hum Mol Genet 25:5188-5197, 2016. DOI:10.1093/hmg/ddw339 - Furuya M, Yao M, Tanaka R, Nagashima Y, Kuroda N, Hasumi H, Baba M, Matsushima J, Nomura F, Nakatani Y
Genetic, epidemiologic and clinicopathologic studies of Japanese Asian patients with Birt-Hogg-Dub? syndrome.
Clinical Genetics 90(5):403-412, 2016. DOI:10.1111/cge.12807 - Taki K, Ohmuraya M, Tanji E, Komatsu H, Hashimoto D, Semba K, Araki K, Kawaguchi Y, Baba H, Furukawa T.
GNAS(R201H) and Kras(G12D) Cooperate to Promote Murine Pancreatic Tumorigenesis Recapitulating Human Intraductal Papillary Mucinous Neoplasm.
Oncogene 35（18）:2407-2412, 2016. DOI:10.1038/onc.2015.294 - Futakuchi M, Fukamachi K, Suzui M
Heterogeneity of tumor cells in the bone microenvironment: mechanisms and therapeutic targets for bone metastasis of prostate or breast cancer.
Adv Drug Deliv Rev 99, 2016. DOI:10.1016/j.addr.2015.11.017 - Yoshikawa Y, Emi M, Hashimoto-Tamaoki T, Ohmuraya M, Sato A, Tsujimura T, Hasegawa S, Nakano T, Nasu M, Pastorino S, Szymiczek A, Bononi A, Tanji M, Pagano I, Gaudino G, Napolitano A, Goparaju C, Pass HI, Yang H, Carbone M.
High-density array-CGH With Targeted NGS Unmask Multiple Noncontiguous Minute Deletions on Chromosome 3p21 in Mesothelioma.
Proc Natl Acad Sci U S A. 113(47):13432-13437, 2016. DOI:10.1073/pnas.1612074113 - Wani S., Sugita A., Ohkuma Y., and Hirose Y.
Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation.
The Journal of Biochemistry 160(2):111-120, 2016. DOI:10.1093/jb/mvw018 - *Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D
Hypoxia and hypercapnia inhibit hypothalamic orexin neurons in rats.
Journal of Neurophysiology 116(5):2250-2259, 2016. DOI:10.1152/jn.00196.2016 - Kubo H, Shimono R*,Nakamura S, Koyano K,Jinnai W, Yamato S, Yasuda S, Nakamura M, Tanaka A, Fujii T, Kanenishi K, Chiba Y, Miki T, Kusaka T, Ueno M.
Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets.
Neonatology 111(3)::203-10, 2016. DOI:10.1159/000450721 - Tanaka M., Shiota M., Nakao T., Uemura R., Nishi S., Ohkawa Y., Matsumoto M., Yamaguchi M., Osada-Oka M., Inagaki A., Takahashi K., Nakayama KI., Gi M., Izumi Y., Miura K., Iwao H.
Identification of low-abundance proteins in serum via the isolation of HSP72 complexes.
J. Proteomics 136:214-21, 2016. DOI:10.1016/j.jprot.2016.01.008 - Ueno H.
Identification of normal and neoplastic stem cells by the multicolor lineage tracing method.
Pathology International 66(8):423-430, 2016. DOI:10.1111/pin.12425 - Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T and Sumiko Watanabe S
Identification of RNA-binding protein LARP4B as a tumor suppressor in glioma.
Cancer Res. 76(8):2254-2264, 2016. DOI:10.1158/0008-5472.CAN-15-2308 - Yoshinori Asano, Tatsuya Kawase, Atsushi Okabe, Shuichi Tsutsumi, Hitoshi Ichikawa, Satoko Tatebe, Issay Kitabayashi, Fumio Tashiro, Hideo Namiki, Tadashi Kondo, Kentaro Semba, Hiroyuki Aburatani, Yoichi Taya, Hitoshi Nakagama and Rieko Ohki
IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.
Scientific Reports 6:19174, 2016. DOI:10.1038/srep19174 - Tetsuhisa Otani, Yosuke Ogura, Kazuyo Misaki, Takuya Maeda, Akiyo Kimpara, Shigenobu Yonemura, Shigeo Hayashi
IKKε inhibits PKC to promote Fascin-dependent actin bundling.
Development 143:3806-3816, 2016. DOI:10.1242/dev.138495 - Shibata N, Kashima M, Ishiko T, Nishimura O, Rouhana L, Misaki K, Yonemura S, Saito K, Siomi H, Siomi MC, Agata K.
Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian.
Dev. Cell 37:226-37., 2016. DOI:10.1016/j.devcel.2016.04.009 - Ye X, Zhou Q, Matsumoto Y, Moriyama M, Kageyama S, Komatsu M, Satoh S, Tsuchida M, Saijo Y.
Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma.
Anticancer Res. 36:6021-6029, 2016. - Lee W, Kim D, Rivnay J, Matsuhisa N, Lonjaret T, Yokota T, Yawo H, Sekino M, Malliaras GG, Someya T.
Integration of Organic Electrochemical and Field-Effect Transistors for Ultraflexible, High Temporal Resolution Electrophysiology Arrays.
Adv Mater. 28(44):9722-9728, 2016. DOI:10.1002/adma.201602237 - Wakaizumi K, Kondo T, Hamada Y, Narita M, Kawabe R, Narita H, Watanabe M, Kato S, Senba E, Kobayashi K, Kuzumaki N, Yamanaka A, Morisaki H, *Narita M
Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise: A study for specific neural control with Gi-DREADD in mice.
Molecular Pain 12:1744806916681567., 2016. DOI:10.1177/1744806916681567 - Iizuka K, Yokomizo T, Watanabe N, Tanaka Y, Osato M, Takaku T, Komatsu N.
Lack of Phenotypical and Morphological Evidences of Endothelial to Hematopoietic Transition in the Murine Embryonic Head during Hematopoietic Stem Cell Emergence.
PLoS One 11(5):e0156427, 2016. DOI:10.1371/journal.pone.0156427 - Maekawa T, Sasaoka T, Azuma S, Ichikawa T, Melrose HL, Farrer MJ, Obata F;
Leucine-rich repeat kinase 2 (LRRK2) regulates alpha-synuclein clearance in microglia.
BMC Neuroscience 17 (1):77, 2016. DOI:10.1186/s12868-016-0315-2 - Kanda M, Nagai T, Takahashi T, Liu ML, Kondou N, Naito AT, Akazawa H, Sashida G, Iwama A, Komuro I, Kobayashi Y.
Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction.
PLoS One 11(5):e0156562., 2016. DOI:10.1371/journal.pone.0156562 - Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F.
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nat Commun. 7:12547, 2016. DOI:10.1038/ncomms12547 - Baba M, Toyama H, Sun L, Takubo K, Suh H-C, Hasumi H, Nakamura-Ishizu A, Hasumi Y, Klarmann KD, Schmidt LS, Linehan WM, Suda T, Keller JR
Loss of Folliculin disrupts hematopoietic stem cell quiescence and homeostasis resulting in bone marrow failure.
Stem Cells 34(4):1068-1082, 2016. DOI:10.1002/stem.2293 - Sumiyoshi T, Sato K, Yamamoto H, Iwasaki YW, Siomi H, Siomi MC.
Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells.
Genes Dev. 30:1617-1622., 2016. DOI:10.1101/gad.283929.116 - Ichinose K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri S-Y, Iwamoto N, Tamai M, Arima K, Nakamura H, Obata Y, Yamamoto K, Origuchi T, Nishino T, Kawakami A and Tsokos GC
Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.
Arthritis and Rheumatology 68(4):944-952, 2016. DOI:10.1002/art.39499 - Saito M, Okumura K, Yoshizawa Y, Munakata H, Isogai E, and Wakabayashi Y.
Meis1 is required for c-Met inhibition to suppress cell proliferation of skin squamous cell carcinoma cells.
Journal of Biosciences and medicines 4(1):53-65, 2016. DOI:10.4236/jbm.2016.47007 - Fukaya R, Ohta S, Yaguchi T, Matsuzaki Y, Sugihara E, Okano H, Saya H, Kawakami Y, Kawase T, Yoshida K, Toda M.
MIF Maintains the Tumorigenic Capacity of Brain Tumor-Initiating Cells by Directly Inhibiting p53.
Cancer Res. 34:5667-5677, 2016. DOI:10.1158/0008-5472.CAN-15-1011 - Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, Mukaida N.
MIP-1α/CCL3-expressing Basophil-Lineage Cells Drive the Leukemic Hematopoiesis of Chronic Myeloid Leukemia in Mice.
Blood 127:2607-2617, 2016. DOI:10.1182/blood-2015-10-673087 - Suzui M, Futakuchi M, Fukamachi K, Numano T, Abd Elgied M, Takahashi S, Ohnishi M, Omori T, Tsuruoka S, Hirose A, Kanno J, Sakamoto Y, Alexander DB, Xu J, Tsuda H
Multiwalled carbon nanotubes intratracheally instilletd into the rat lung induce development of pleural malignant mesothelioma and lung tumors.
Cancer Sci 107(7):924-935, 2016. DOI:10.1111/cas.12954 - Inaba H, Goto H, Kasahara K, Kumamoto K, Yonemura S, Inoko A, Yamano S, Wanibuchi H, He D, Goshima N, Kiyono T, Hirotsune S, Inagaki M.
Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.
J Cell Biol. 212:409-423, 2016. DOI:10.1083/jcb.201507046 - Park S, Komatsu T, Kim SE, Tanaka K, Hayashi H, Mori R, Shimokawa I
Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction.
Aging Cell 16(2):339-348, 2016. DOI:10.1111/acel.12558 - Kitamura, T., Watanabe-Okochi, N., Enomoto, Y., Nakahara, F., Oki, T., Komeno, Y., Kato, N., Doki, N., Uchida, T., Kagiyama, Y., Togami, K., Kawabata, K.C., Nishimura, K., Hayashi, Y., Nagase, R., Saika, M., Fukushima, T., Asada, S., Fujino, T., Izawa, Y., Horikawa, S., Fukuyama, T., Tanaka, Y., Ono, R., Goyama, S., Nosaka, T., Kitaura, J., and Inoue D.
Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).
J Biol Chem. 159:17-25, 2016. DOI:10.1093/jb/mvv114 - Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A and Hikida T.
Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage.
Learning and Memory 23 (7):359-64, 2016. DOI:10.1101/lm.042507.116 - Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M,?Ohmuraya?M, Sato T, Yoshimura SI, Sato K, Harada R, Kim YJ, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A.
Opposing Roles for SNAP23 in Secretion in Exocrine and Endocrine Pancreatic Cells.
J Cell Biol. 215（1）:121-138, 2016. DOI:10.1083/jcb.201604030 - Chowdhury S, *Yamanaka A
Optogenetic activation of serotonergic terminals facilitates GABAergic inhibitory input to orexin/hypocretin neurons.
Scientific reports 6:36039, 2016. DOI:10.1038/srep36039 - Hisha H, and Ueno H.
Organoid Culture of Lingual Epithelial Cells in a Three-Dimensional Matrix.
Methods in molecular biology 1576:93-99, 2016. DOI:10.1007/7651_2016_3 - Toyokuni S
Oxidative stress as an iceberg in carcinogenesis and cancer biology.
Archives of Biochemistry and Biophysics 595:46-49, 2016. DOI:10.1016/j.abb.2015.11.025 - Duquesnes N., Callot C., Jeannot P., Daburon V., Nakayama KI., Manenti S., Davy A., Besson A.
p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith?Wiedemann syndrome.
J. Pathol. 239:250-61, 2016. DOI:10.1002/path.4721 - Saito, T., Waguri, S (38人中34番目)., *Komatsu, M (38人中38番目).
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.
Nat Commun 7, 2016. DOI:10.1038/ncomms12030 - Hatano A, Matsumoto M, Nakayama KI.
Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling.
Genes Cells 21:1095-112, 2016. DOI:10.1111/gtc.12406 - Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K.
Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons.
Mol. Cell 63:p1-12, 2016. DOI:10.1016/j.molcel.2016.06.008 - Umeda K, Ishizuka T, Yawo H, Shoji W.
Position- and quantity-dependent responses in zebrafish turning behavior.
Sci Rep. 6:27888, 2016. DOI:10.1038/srep27888 - Doi H, Kitajima Y, Luo L, Yan C, Tateishi S, Ono Y, Urata Y, Goto S, Mori R, Masuzaki H, Shimokawa I, Hirano A, Li TS
Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing.
Sci Rep 6:18844, 2016. DOI:10.1038/srep18844 - Lim, BC., Matsumoto, S., Yamamoto, H., Mizuno, H., Kikuta, J., Ishii, M., and Kikuchi, A
Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.
J. Cell Sci 129:3115-3129, 2016. DOI:10.1242/jcs.185439 - Guida V, Cernilogar FM, Filograna A, De Gregorio R, Ishizu H, Siomi MC, Schotta G, Bellenchi GC, Andrenacci D.
Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.
Genetics 204:631-644, 2016. DOI:10.1534/genetics.116.187922 - Honda T, Soeda S, Tsuda K, Yamaguchi C, Aoyama K, Morinaga T, Yuki R, Nakayama Y, Yamaguchi N, Yamaguchi N
Protective role for lipid modifications of Src-family kinases against chromosome missegregation.
Sci Rep.? 6:38751, 2016. DOI:10.1038/srep38751 - Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S.
Protein Kinase D Regulates Positive Selection of CD4 + Thymocytes Through Phosphorylation of SHP-1.
Nat Commun. 7:12756, 2016. DOI:10.1038/ncomms12756 - 8. Toda, S., Iguchi, Y., Lin, Z., Nishikawa. H, Nagasawa, T., Watanabe, H., & Minabe, Y.
Reconsidering animal models of major depressive disorder in the elderly.
Frontiers in Aging Neuroscience 8:188, 2016. DOI:10.3389/fnagi.2016.00188 - Fujieda Y., Amengual O., Matsumoto M., Kuroki K., Takahashi H., Kono M., Kurita T., Otomo K., Kato M., Oku K., Bohgaki T., Horita T., Yasuda S., Maenaka K., Hatakeyama S., Nakayama KI., Atsumi T.
Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.
Rheumatology 55:1117-26, 2016. DOI:10.1093/rheumatology/kew005 - Kuribayashi H, Tsuhako A, Kikuchi M, Yoshida N, Koso H, Watanabe S
Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina.
Exp. Eye Res. 152:34-42, 2016. DOI:10.1016/j.exer.2016.09.005 - Chin DW, Sakurai M, Nah GS, Du L, Jacob B, Yokomizo T, Matsumura T, Suda T, Huang G, Fu XY, Ito Y, Nakajima H, Osato M.
RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.
Blood Cancer J. 6:e379, 2016. DOI:10.1038/bcj.2015.105 - Watabe, A.M., Nagase, M., Hagiwara, A., Hida, Y., Tsuji, M., Ochiai, T., Kato, F., Ohtsuka, T.
SAD-B Kinase regulates presynaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory.
Journal of Neurochemistry 136(1):36-47, 2016. DOI:10.1111/jnc.13379 - Meisler MH, Helman G, Hammer MF, Fureman BE, Gaillard WD, Goldin AL, Hirose S, Ishii A, Kroner BL, Lossin C, Mefford HC, Parent JM, Patel M, Schreiber J, Stewart R, Whittemore V, Wilcox K, Wagnon JL, Pearl PL, Vanderver A, Scheffer IE.
SCN8A encephalopathy: Research progress and prospects.
Epilepsia 57(7):1027-1035, 2016. DOI:10.1111/epi.13422 - Kimiko Shimizu, Yodai Kobayashi, Erika Nakatsuji, Maya Yamazaki, Shigeki Shimba, Kenji Sakimura & Yoshitaka Fukada
SCOP/PHLPP1b mediates circadian regulation of long-term recognition memory.
Nature Communications 7:12926, 2016. DOI:10.1038/ncomms12926 - Jun J. Nakano, Kimiko Shimizu, Shigeki Shimba & Yoshitaka Fukada
SCOP/PHLPP1β in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior.
Scientific Reports 6:33500, 2016. DOI:10.1038/srep33500 - Yang H, Ni HM, Guo F, Ding Y, Shi YH, Lahiri P, Fr?hlich LF, R?licke T, Smole C, Schmidt VC, Zatloukal K, Cui Y, Komatsu M, Fan J, Ding WX.
Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice.
J Biol Chem. 291:18663-18674, 2016. DOI:10.1074/jbc.M116.739821 - Takamura, S., Yagi, H., Hakata, Y., Motozono, C., McMaster, SR., Tomura, M., Nakayama, T., Woodland, DL., Kohlmeier, JE., Miyazawa, M.
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
J Exp Med. 213:3057-3073, 2016. DOI:10.1084/jem.20160938 - Habisov, S., Huber, J., Ichimura, Y., Akutsu, M., Rogova, N., Loehr, F., McEwan, D.G., Johansen, T., Dikic, I., Doetsch, V., Komatsu, M., Rogov, V.V., *Kirkin, V.
Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.
J Biol Chem 291:9025-9041, 2016. DOI:10.100xxx2/ejoc.201601023 - Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, Nureki O.
Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.
Sci Rep. 6:34756?, 2016. DOI:10.1038/srep34756 - Sugimura, Y.K., Takahashi, Y., Watabe, A.M., Kato, F.
Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala.
Journal of Neurophysiology 115:2721-2739, 2016. DOI:10.1152/jn.00946.2015 - Yasuda D, Nakajima M, Yuasa A, Obata R, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.
Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity.
Bioorg Med Chem Lett 26:5956-5959, 2016. DOI:10.1016/j.bmcl.2016.10.083 - Katsushima K, Natsume A, Ohka F, Shinjo K, Hatanaka A, Ichimura N, Sato S, Takahashi S, Kimura H, Totoki Y, Shibata T, Naito M, Kim HJ, Miyata K, Kataoka K, Kondo Y.
Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment.
Nat Commun 7:13616-, 2016. DOI:10.1038/ncomms13616 - Fuchs H, Sabrautzki S, Przemeck G, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, O?stereicher M, Hans W, Abe K et al.
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.
G3・Genes| Genomes| Genetics 6:4035-4046, 2016. DOI:10.1534/g3.116.033670 - Inutsuka A, Yamashita A, Chowdhury S, Nakai J, Ohkura M, Taguchi T, *Yamanaka A
The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation.
Scientific reports 6:29480, 2016. DOI:10.1038/srep29480 - Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A.
The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.
J Exp Med 213(8):1459-1477, 2016. DOI:10.1084/jem.20151121 - Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S.
The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.
J. Mol. Cell. Cardiol. 100:43-53, 2016. DOI:10.1016/j.yjmcc.2016.09.013 - Toyokuni S
The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy.
Pathology International 66:245-259, 2016. DOI:10.1111/pin.12396 - Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C, Hirao A.
Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance.
J Biol Chem. 291:21496-21509, 2016. DOI:10.1074/jbc.M116.734756 - Takeishi S., Nakayama KI.
To wake up cancer stem cells, or to let them sleep, that is the question.
Cancer Sci. 107:875-81, 2016. DOI:10.1111/cas.12958 - Miyamoto D,?Hirai D,?Fung CC,?Inutsuka A,?Odagawa M,?Suzuki T,?Boehringer R,?Adaikkan C,?Matsubara C,?Matsuki N,?Fukai T,?McHugh TJ,Yamanaka A,?*Murayama M
Top-down cortical input during NREM sleep consolidates perceptual memory.
Science 352(6291):1315-1318, 2016. DOI:10.1126/science.aaf0902 - Eisuke Sato, Yurika Tanabe, Naoya Nakajima, Akifumi Ohkubo, and Kiyotake Suenaga
Total Synthesis of Biselyngbyolide B.
Organic Letters 18 (9):2047-2049, 2016. DOI:10.1021/acs.orglett.6b00660 - Ju J, Hirose S, Shi XY, Ishii A, Hu LY, Zou LP.
Treatment with Oral ATP decreases alternating hemiplegia of childhood with de novo ATP1A3 Mutation.
Orphanet Journal of Rare Diseases. 11(1):55, 2016. DOI:10.1186/s13023-016-0438-7 - Inoue, D., Nishimura, K., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K-I. and Kitamura, T
Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.
Experimental Hematology 44:172 -176, 2016. DOI:10.1016/j.exphem.2015.11.011 - Takaori T, Kumakura A, Ishii A, Hirose S, Hata D.
Two mild cases of Dravet syndrome with truncating mutation of SCN1A.
Brain & Development 39(1):72-74, 2016. DOI:10.1016/j.braindev.2016.07.006 - Takatoshi Iijima, Chiharu Hidaka and Yoko Iijima.
Update Article: Spatio-temporal regulations and functions of neuronal alternative RNA splicing in developing and adult brains.
Neuroscience Research. 109:43473, 2016. DOI:10.1016/j.neures.2016.01.010 - Matsunaga R, Nishino T, Yokoyama A, Nakashima A, Kikkawa U, Konishi H.
Versatile function of the circadian protein CIPC as a regulator of Erk activation.
Biochem Biophys Res Commun. :377-383, 2016. DOI:10.1016/j.bbrc.2015.11.117 - Abedini, A., Zamberlam, G., Lapointe, E., Tourigny, C., Boyer, A., Paquet, M., Hayashi, K., Honda, H., Kikuchi, A., Price, C., and Boerboom, D
WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
FASEB J 30(4):1534-1547, 2016. DOI:10.1096/fj.15-280313 - Matsumoto, S., Kurimoto, T., Taketo, M., Fujii, S., and Kikuchi, A
Wnt-Myb pathway suppresses KIT expression to control the timing of salivary proacinar differentiation and duct formation.
Development 143(13):2311-2324, 2016. DOI:10.1242/dev.134486 - 山中章弘
オレキシンを中心とした睡眠覚醒調節の神経機構.
高齢者の睡眠とその障害 :221-228, 2016. - 蛯原功介、山中章弘
オレキシン受容体の関連物質をターゲットとした臨床応用.
Clinical Neuroscience 34(7):740-741, 2016. - 山中章弘
オレキシン受容体の種類.
Clinical Neuroscience 34(5):496-497, 2016. - 山下貴之、山中章弘
オレキシン受容体の生理的および薬理的機能.
Clinical Neuroscience 34(6):612-613, 2016. - 小川宏人
昆虫の短中距離ナビゲーションを支える神経基盤.
日本ロボット学会誌 34:685-689, 2016. DOI:10.7210/jrsj.34.685 - 渡邉 貴樹, 上阪 直史, 狩野 方伸
生後発達期の小脳におけるシナプス刈り込みのメカニズム.
生化学 88(5):621-629, 2016. DOI:10.14952/SEIKAGAKU.2016.880621 - 山本一男
哺乳類の細胞サイズを規定する分子基盤.
実験医学 34(15):2615-2620, 2016.
