成果論文リスト

本支援による成果を含む論文として支援依頼者から報告があった論文を発表の新しい順に並べました。成果論文には「先端モデル動物支援」の課題番号「16H06276」を謝辞に入れることをお願いしていますが、課題番号の記載がない論文も含めています。また、前事業「生命科学系3分野（がん・ゲノム・脳）支援活動」の支援を受けた成果のうち、そちらの課題番号のみが記載されたもの（＊）も含まれています。

2018年度
2017年度
2016年度

2018年度

Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S. and Irie, K.
Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin.
Heterocycles 97(1):478-492, 2018. DOI:10.3987/COM-18-S(T)37
Hirotaka Watanabe, et al.
Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells.
Cell Rep. 23:3721-3729, 2018. DOI:10.1016/j.celrep.2018.05.081
和田裕一, 三浦知志, 窪俊一
マンガの読みにおける状況モデルの更新.
マンガ研究 24:93-114, 2018.
Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Ichikawa J, Osada M, Satoh K, Ozaki Y, Suzuki-Inoue K.
Functional characterization of recombinant snake venom rhodocytin: rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis.
J Thromb Haemost 16(5):960-972, 2018. DOI:10.1111/jth.13987
Saito M, Ichikawa J, Ando T, Schoenecker JG, Ohba T, Koyama K, Suzuki-Inoue K, Haro H.
Platelet-Derived TGF-β Induces Tissue Factor Expression via the Smad3 Pathway in Osteosarcoma Cells.
J Bone Miner Res. 33(11):2048-2058, 2018. DOI:10.1002/jbmr.3537
Takayama Y, Ando T, Ichikawa J, Haro H
Effect of Thrombin-Induced MCP-1 and MMP-3 Production Via PAR1 Expression in Murine Intervertebral Discs.
Sci. Rep 8(1):11320, 2018. DOI:10.1038/s41598-018-29669-z
Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama S
Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells.
Sci. Rep. 8:6760, 2018. DOI:10.1038/s41598-018-25189-y
Kamijo Y, Kawahara K, Yoshinaga T, Kurata H, Arima K, Furukawa T.
A novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analyses.
Oncoscience. 5:88-98, 2018. DOI:10.18632/oncoscience.411
Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A.
FEAT enhances INSL3 expression in testicular Leydig cells.
Genes to cells 23:952-962, 2018. DOI:10.1111/gtc.12644
Hideaki ABE, Manabu NATSUMEDA, Yu KANEMARU, Jun WATANABE, Yoshihiro TSUKAMOTO, Masayasu OKADA, Junichi YOSHIMURA, Makoto OISHI, and Yukihiko FUJII
MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas.
Neurol Med Chir (Tokyo) 58:290-295, 2018. DOI:10.2176/nmc.ra.2018-0044
岡田正康, 棗田学, 河嵜麻実, 大石誠, 藤井幸彦, 五十嵐道弘
細胞突起形成抑制による膠芽腫治療戦略.
新潟県医師会報 814（1）:9-10, 2018.
Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
Neurosci Res. in press, 2018. DOI:10.1016/j.neures.2018.08.016
Saitoh F, Hagiwara H, Wakatsuki S, Araki T.
Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency.
Neurosci Res. in press, 2018. DOI:10.1016/j.neures.2018.08.015
Mori R, Tanaka K, Shimokawa I
Identification and functional analysis of inflammation-related miRNAs in skin wound repair.
Dev Growth Differ 60(6):306-315, 2018. DOI:10.1111/dgd.12542
de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu To, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R
Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds.
EMBO Mol Med 10(10):e9024, 2018. DOI:10.15252/emmm.201809024
Umehara T, Mori R, Mace K, Murase T, Abe Y, Yamamoto T, Ikematsu K
Identification of specific microRNAs in neutrophils of type 2 diabetic mice: overexpression of microRNA-129-2-3p accelerates diabetic wound healing.
Diabetes in press, 2019.
Oikawa D, Shiota M, Wanibuchi H, Tokunaga F.
Generation of rat monoclonal antibodies against a deubiquitinase, ovarian tumor domain-containing protein 1.
Monoclon Antib Immunodiagn Immunother. 37(4):180-184, 2018. DOI:10.1089/mab.2018.0023
Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System.
SLAS Discovery 23(10):1018-1029, 2018. DOI:10.1177/2472555218793066
Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O.
Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
Nature Commun. 9:4424, 2018. DOI:10.1038/s41467-018-06922-7
Akatsuka S, Li GH, Toyokuni S
Superiority of rat over murine model for studies on the evolution of cancer genome.
Free Radical Research 7:1-5, 2018. DOI:10.1080/10715762.2018.1467562
Toyokuni S
Iron Addiction with Ferroptosis-resistance in Asbestos-induced Mesothelial Carcinogenesis: Toward the Era of Mesothelioma Prevention.
Free Radical Biology & Medicine , 2019. DOI:10.1016/j.freeradbiomed.2018.10.401
Okada K, Nishizawa K, Setogawa S, Hashimoto K, Kobayashi K.
Task-dependent function of striatal cholinergic interneurons.
Eur J Neurosci 47(10):1174-1183., 2018. DOI:10.1111/ejn.13768
Kurihara Y, Makita Y, Kawashima M, Fujita T, Iwasaki S, and Matsui M.
Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis.
Proc Natl Acad Sci U S A. 115(30):7831-7836, 2018. DOI:10.1073/pnas.1804971115
Taiwa K, Yokoi S, Mito M2, Fujii K, Kimura Y, Iwasaki S, Nakagawa S.
UPA-Seq: Prediction of Functional LncRNAs Using Differential Sensitivity to UV Crosslinking.
RNA 24(12):1785-1802., 2018. DOI:10.1261/rna.067611.118
Akichika S., Hirano S., Shichino Y., Suzuki T., Nishimasu H., Ishitani R., Sugita A., Hirose Y., Iwasaki S., Nureki O., and Suzuki T.
Cap-specific terminal N6-methylation of RNA by an RNA polymerase II-associated methyltransferase.
Science , 2018. DOI:10.1126/science.aav0080
Iwasaki S.*, Iwasaki W., Takahashi M., Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T.*, and Ingolia NT.*
The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA.
Mol. Cell 73:1–10, 2019. DOI:10.1016/j.molcel.2018.11.026
Tsutomu Fukuda, Yusuke Nanjo, Masahiro Fujimoto, Kenyu Yoshida, Yuko Natsui, Fumito Ishibashi, Fumiyasu Okazaki, Hideto To, Masatomo Iwao
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.
Bioorganic and Medicinal Chemistry in press, 2019. DOI:10.1016/j.bmc.2018.11.037 ＊
Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
Generation of Rat Monoclonal Antibodies Specific for DZIP3.
Monoclon Antib Immunodiagn Immunother. 37:153-157, 2018. DOI:10.1089/mab.2018.0005
Hattori M, Ishikawa O, Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki S, Wakamatsu K, Tokunaga F, Shimizu A.
In-frame Val216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response.
J Dermatol Sci. 91:35-42, 2018. DOI:10.1016/j.jdermsci.2018.03.012
Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time- Resolved Fluorescence (HTRF)-Based Assay System.
SLAS Discov. 23:1018-1029, 2018. DOI:10.1177/2472555218793066
Oikawa D, Shiota M, Goto E, Komakura K, Wanibuchi H, Tokunaga F.
Generation of Rat Monoclonal Antibodies against a Deubiquitinase, OTUD1.
Monoclon Antib Immunodiagn Immunother. 37:180-184, 2018. DOI:10.1089/mab.2018.0023
Bando Y*, Sakamoto M* (Co-first and corresponding author), Kim S, Ayzenshtat I, Yuste R.
Comparative evaluation of genetically encoded voltage indicators.
Cell Rep. , 2016.
Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N
Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.
Int J Mol Sci. 19(6):E1811, 2018. DOI:10.3390/ijms19061811
Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N
Forkhead box protein A1 confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.
J Cell Biochem. in press, 2018. DOI:10.1002/jcb.27551
Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.
Oncogene in press, 2018. DOI:10.1038/s41388-018-0481-z
Kurataka Otsuka, Yusuke Yamamoto, Takahiro Ochiya
Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer.
Oncotarget 9(37):24718-24730, 2018. DOI:10.18632/oncotarget.25339
Miyasato Y, Yoshizawa T. et al.
Sirtuin 7 deficiency ameliorates cisplatin-induced acute kidney injury through regulation of the inflammatory response.
Sci. Rep 8:5927, 2018. DOI:10.1038/s41598-018-24257-7
Fukuda M, Yoshizawa T. et al.
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
Nat Commun 19:2833, 2018. DOI:10.1038/s41467-018-05187-4
Yokoshima Y, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Kato R, Hozumi J, Abe H, Azuma K, Tsuchida R, Yamada Y, Japanese TR-Cancer Pain Research Group.
Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain: An exploratory study.
Neuropsychopharmacology Report in press, 2018. DOI:10.1002/npr2.12030
Kokuda R, Watanabe R, Okuzaki D, Akamatsu H, Oneyama C.
MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression.
Genes Cells 23(8):688-701, 2018. DOI:10.1111/gtc.12610
Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration.
Neurochem Int 119:190-198, 2018. DOI:10.1016/j.neuint.2018.01.003
Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.
UBL3 modification influences protein sorting to small extracellular vesicles.
Nature Commun. 9:3936, 2018. DOI:10.1038/s41467-018-06197-y
Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H.
Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
Sci. Rep. 8:e14827, 2018. DOI:10.1038/s41598-018-33139-x
Okazaki S, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Kinoshita M, Inoue E, Ohmori T, Someya T, Sora I.
Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia.
Prog Neuropsychopharmacol Biol Psychiatry 83:33-41, 2018. DOI:10.1016/j.pnpbp.2018.01.001
Kimura A, Hishimoto A, Otsuka I, Okazaki S, Boku S, Horai T, Izumi T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
Loss of chromosome Y in blood, but not in brain, of suicide completers.
PLoS One. 13（1）:e0190667, 2018. DOI:10.1371/journal.pone.0190667
Eguchi N, Sora I, Muguruma K.
Self-organizing cortex generated from human iPSCs with combination of FGF2 and ambient oxygen.
Biochem Biophys Res Commun. 498(4):729-735, 2018. DOI:10.1016/j.bbrc.2018.03.049
Zhang Y, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Yamamori H, Boku S, Horai T, Someya T, Ohmori T, Hashimoto R, Sora I
Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population.
J Psychiatr Res. 103:161-166, 2018. DOI:10.1016/j.jpsychires.2018.05.014
Horai T, Hishimoto A, Otsuka I, So T, Mouri K, Shimmyo N, Boku S, Okishio N, Sora I.
A cross-sectional study exploring useful indicators for low bone mineral density in male alcoholic patients.
Neuropsychiatr Dis Treat 14:663-669, 2018. DOI:10.2147/NDT.S153360
Yu Chen, Masahiro Takikawa, Shuichi Tsutsumi, Yoko Yamaguchi, Atsushi Okabe, Mayuna Shibata, Tatsuya Kawase, Akane Sada, Issei Ezawa, Yuhei Takano, Kisaburo Nagata, Yutaka Suzuki, Kentaro Semba, Hiroyuki Aburatani, Rieko Ohki.
PHLDA1, another PHLDA family protein that inhibits Akt.
Cancer Sci. 109:3532-3542, 2018. DOI:10.1111/cas.13796
Nakatsumi H., Oka T., Higa T., Shirane M., Nakayama KI.
Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1.
Genes Cells 23:599-605, 2018. DOI:10.1111/gtc.12597
Kikuchihara S, Sugio S, Tanaka KF, Watanabe T, Kano M, Yamazaki Y, Watanabe M, Ikenaka K.
Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice.
J Neurochem 147(3):344-360, 2018. DOI:10.1111/jnc.14486
Kano M, Watanabe T, Uesaka N, Watanabe M.
Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum.
Cerebellum. 17(6):722–734, 2018. DOI:10.1007/s12311-018-0964-z
Ashida, Y., Yanagita, R. C., Kawanami, Y., Okamura, M., Dan, S. and Irie, K.
Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin.
Heterocycles in press
Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H
Targeted expression of step-function opsins in transgenic rats for optogenetic studies.
Sci. Rep 8(1):5435, 2018. DOI:10.1038/s41598-018-23810-8
Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H
Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo.
J Physiol Sci :Epub ahead of print, 2018. DOI:10.1007/s12576-018-0618-4
Asano T, Igarashi H, Ishizuka T, Yawo H
Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light.
Front Neurosci. 12:561, 2018. DOI:10.3389/fnins.2018.00561
Shen YC, Sasaki T, Matsuyama T, Yamashita T, Shichida Y, Okitsu T, Yamano Y, Wada A, Ishizuka T, Yawo H, Imamoto Y.
Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues.
Biochemistry 57（38）:5544-5556, 2018. DOI:10.1021/acs.biochem.8b00583
Abe K, Yawo H.
Quantitative study of the somatosensory sensitization underlying cross-modal plasticity.
PLoS One. 13(12):e0208089, 2018. DOI:10.1371/journal.pone.0208089
Tsuge M, Osaki M, Sasaki R, Hirahata M, Okada F
SK-216, a novel inhibitor of plasminogen activator inhibitor-1, suppresses lung metastasis of human osteosarcoma.
Int J Mol Sci 19(3):736, 2018. DOI:10.3390/ijms19030736
Matsuyama S, Kage Y, Fujimoto N, Ushijima T, Tsuruda T, Kitamura K, Shiose A, Asada Y, Sumimoto H, Takeya R.
Interaction between cardiac myosin-binding protein C and formin Fhod3.
Proc Natl Acad Sci U S A. 115(19):E4386-E4395, 2018. DOI:10.1073/pnas.1716498115
Tsutomu Fukuda, Yuri Matsuo, Fuyuki Matsuoka, Naoki Yoshioka, Gen Onodera, Masanari Kimura, Fumito Ishibashi, Masatomo Iwao
Synthesis and evaluation of topoisomerase I inhibitors possessing the 5,13-dihydro-6H-benzo[6,7]indolo[3,2-c]quinolin-6-one scaffold.
Heterocycles 99 in press, 2019. DOI:10.3987/COM-18-S(F)70 ＊
Vu HT, Kobayashi M, Hegazy AM, Tadokoro Y, Ueno M, Kasahara A, Takase Y, Nomura N, Peng H, Ito C, Ino Y, Todo T, Nakada M, Hirao A.
Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas.
Cancer Sci. 109:2497-2508, 2018. DOI:10.1111/cas.13695
Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T.
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.
Nature Commun. 9(1):2733, 2018. DOI:10.1038/s41467-018-05085-9
Saika M, Inoue D, Nagase R, Sato N, Tsuchiya A, Yabushita T, Kitamura T, Goyama S.
ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFb pathway genes through histone deacetylation.
Sci. Rep. 8(1):15873, 2018. DOI:10.1038/s41598-018-33881-2
Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T
Deficiency of AMPA receptor-palmitoylation aggravates seizure susceptibility.
J Neurosci 38:10220-10235, 2018. DOI:10.1523/JNEUROSCI.1590-18.2018
Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T
Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation deficient mice.
Neuropsychopharmacology Reports , 2018. DOI:10.1002/npr2.12044
Nakashima C, Yamamoto K, Fujiwara-Tani R, Luo Y, Matsushima S, Fujii K, Ohmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H
Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.
Cancer Sci. 109(6):2036-2045, 2018. DOI:10.1111/cas.13594
Sasahira T, Nishiguchi Y, Kurihara-Shimomura M, Nakashima C, Kuniyasu H, Kirita T.
NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma.
J Cancer Res Clin Oncol 144(5):875-882, 2018. DOI:10.1007/s00432-018-2612-x
Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H, Kirita T.
The multifarious functions of pyruvate kinase M2 in oral cancer cells.
Int J Mol Sci 19(10), 2018. DOI:10.3390/ijms19102907
Matsushima-Otsuka S, Fujiwara-Tani R, Sasaki T, Ohmori H Nakashima C, Kishi S, Nishiguchi Y, Fujii K, Luo Y, Kuniyasu H
Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma.
Oncotarget 9(93):36561-36574, 2018. DOI:10.18632/oncotarget.26337
Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Nishiguchi Y, Kishi S, Mori S, Goto K, Kondoh M, Kuniyasu H
Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer.
Oncotarget in press, 2018.
Hashimoto Y, Hata T, Tada M, Iida M, Watari A, Okada Y, Doi T, Kuniyasu H, Yagi K, Kondoh M
Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2.
Eur J Pharm Sci 117:161-167, 2018. DOI:10.1016/j.ejps.2018.02.016
Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy.
Pathobiology in press, 2018.
Miyagawa Y, Mori T, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Ohmori H, Kawahara I, Kuniyasu H
Intake of medium-chain fatty acids induces oxidative stress and to atrophy the myocardium.
Lipids in Health and Disease 17:258, 2018. DOI:10.1186/s12944-018-0908-0
Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, Ríos A, Kawabata M, Kimura M, Sakai Y, *Isomura Y
Area-specific modulation of functional cortical activity during block-based and trial-based proactive inhibition.
Neuroscience 388:297-316, 2018. DOI:10.1016/j.neuroscience.2018.07.039
Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, *Isomura Y, *Kimura M
Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways.
Neuron 99(6):1302-1314, 2018. DOI:10.1016/j.neuron.2018.08.002
*Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, Ríos A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y
Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.
J Neurosci , 2018. DOI:10.1523/JNEUROSCI.1584-18
Wang C, Oshima M, Sato D, Matsui H, Kubota S, Aoyama K, Nakajima-Takagi Y, Koide S, Matsubayashi J, Mochizuki-Kashio M, Nakano-Yokomizo T, Bai J, Nagao T, Kanai A, Iwama A, Sashida G.
Ezh2 loss propagates hypermethylation at T-cell differentiation-regulating genes to promote leukemic transformation.
J Clin Invest 128(9):3872-86, 2018. DOI:10.1172/JCI94645
Aoyama K, Oshima M, Koide S, Suzuki E, Mochizuki-Kashio M, Kato Y, Tara S, Shinoda D, Hiura N, Nakajima-Takagi Y, Sashida G, Iwama A.
Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.
iScience 9:161-174, 2018. DOI:10.1016/j.isci.2018.10.008
Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger G, Wang J, Dong Y, Zhou Y, Wang J, Wu LY, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, et al.
Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
Cancer Discovery 8(11):1438-57, 2018. DOI:10.1158/2159-8290.CD-17-1203
Ito N., Mohammad B., A., Shah A., I., A., and *Ohta K.
Transdifferentiation of human somatic cells by ribosome.
Dev Growth Differ. 60:241-247, 2018. DOI:10.1111/dgd.12538
Tsurumaru, H., Ito, N., Mori, K., Wakai, S., Uchiyama, T., Iino, T., Hosoyama, A., Ataku, H., Nishijima, K., Mise, M., Shimizu, A., Harada, T., Horikawa, H., Ichikawa, N., Sekigawa, T., Jinno, K., Tanikawa, S., Yamazaki, J., Sasaki, K., Yamazaki, S., Fujita, N., and *Harayama, S.
An extracellular [NiFe] hydrogenase mediating iron corrosion is encoded in a genetically unstable genomic island in Methanococcus maripaludis.
Scientific Reports 8 8:15149, 2018. DOI:10.1038/s41598-018-33541-5
Ohta K, Aoyama E, Ahmad SAI, Ito N, Anam MB, Kubota S, Takigawa M
CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.
J Cell Commun Signal. , 2018. DOI:10.1007/s12079-018-0487-x
Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output.
Cell Rep. 25:2704-2715, 2018. DOI:10.1016/j.celrep.2018.11.016
Tsukahara, R., Yamamoto, S., Yoshikawa, K., Gotoh, M., Tsukahara, T., Neyama, H., Ishii, S., Akahoshi, N., Yanagida, K., Sumida, H., Araki, M., Araki, K., Yamamura, K. I., Murakami-Murofushi, K., Ueda, H.
LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.
J Pharmacol.Sci. 136:93-96, 2018. DOI:10.1016/j.jphs.2018.01.001
Sumiyoshi K, Koso H, Watanabe S.
Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma.
Cancer Sci. 109(5):1513-1523, 2018. DOI:10.1111/cas.13579
Koso H, Nishinakamura R, Watanabe S
Sall1 regulates microglial morphology cell autonomously in the developing retina.
Adv Exp Med Biol :209-215, 2018. DOI:10.1007/978-3-319-75402-4_26
Kawamura Y, Yamanaka K, Poh B, Kuribayashi H, Koso H, Watanabe S
The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development.
Biochem Biophys Res Commun. 503(4):3023-3030, 2018. DOI:10.1016/j.bbrc.2018.08.088
M. Ishido*
An Overview of Development of Quantitative Neurotoxicity Testing In vitro.
J Applied Life Sci Intl. 19:2394-1103, 2018. DOI:10.9734/JALSI/2018/45377
M. Ishido*
The temporal turning window for rat behavioral phenotypes by rotenone.
Fund. Toxicol. Sci. 5, 2018.
Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrian Marchand, Fernaldo Richtia Winnerdy, Valerie Gabelica, Anh Tuan Phan, Masato Katahira & Kazuo Nagasawa
Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound.
ChemBioChem 19:2268-2272, 2018. DOI:10.1002/cbic.201800425
Yue Ma, Yamato Tsushima, Mai Sakuma, Shogo Sasaki, Keisuke Iida, Sachiko Okabe, Hiroyuki Seimiya, Takatsugu Hirokawa, Kazuo Nagasawa
Development of G-quadruplex ligand for selective induction of parallel-type topology.
Org. Biomol. Chem. 16:7375-7382, 2018. DOI:10.1039/C8OB01702F
Shadi Sedghi Masoud, Kazuo Nagasawa
i-Motif-binding ligand and their effects on the structure and biological functions of i-motif.
Chem. Pharm. Bull. 66:1091-1103, 2018. DOI:10.1248/cpb.c18-00720
Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
Cancer Sci. in press, 2018. DOI:10.1111/cas.13805
Tominaga, K., Minato, H., Murayama, T., Sasahara, A., Nishimura, T., Kiyokawa, E., Kanauchi, H., Shimizu, S., Sato, A., Nishioka, K., Tsuji, E., Yano, M., Ogawa, T., Ishii, H., Mori, M., Akashi, K., Okamoto, K., Tanabe, M., Tada, K., Tojo, A., Gotoh, N.
Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.
Proc Natl Acad Sci U S A. in press, 2018.
Tamari, K., Konno, M., Asai, A., Koseki., Jun., Hayashi, K., Kawamoto, K., Murai, N., Matsufuji, S., Isohashi, F., Satoh, T., Goto, N., Tanaka, S., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells.
Cell Death Discovery 4(104）, 2018. DOI:10.1038/s41420-018-0117-7
Toratani, M., Konno, M., Asai, A., Koseki, J., Kawamoto, K., Tamari, K., Li, Z., Sakai, D., Kudo, T., Satoh, T., Sato, K., Motooka, D., Okuzaki, D., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
Ability of a convolutional neural network to differentiate between mouse and human cell lines and their radioresistant clones using microscopic images.
Cancer Res. 78, 2018. DOI:10.1158/0008-5472
Toshiyama, R., Konno, M., Eguchi, H., Takemoto, H., Noda, T., Asai, A., Koseki, J., Haraguchi, N., Ueda, Y. Matsushita, K., Asukai, K., Ohashi, T., Iwagami, Y., Yamada, D., Sakai, D., Asaoka, T., Kudo, T., Kawamoto, K., Gotoh, K., Kobayashi, S., Satoh, T., Doki, Y., Nishiyama, N., Mori, M.
Poly(ethylene glycol)–poly(lysine) block copolymer–ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.
Oncogene , 2018. DOI:10.1038/s41388-018-0406-x
Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
J Clin Invest 128(12):5603-5619, 2018. DOI:10.1172/JCI121679
Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.
Cerebral Cortex in press, 2018. DOI:10.1093/cercor/bhy253
Ida-Yonemochi H, Morita W, Sugiura N, Kawakami R, Morioka Y, Takeuchi Y, Sato T, Shibata S, Watanabe H, Imamura T, Igarashi M, Ohshima H, Takeuchi K
Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.
Sci. Rep 8:17134-, 2018. DOI:10.1038/s41598-018-35412-5
Yukawa T, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi, M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa S, Takeuchi R, Takahashi H, Kakita A, Someya T, *Nawa H
Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia.
Psychiarty Res 270:940-946, 2018. DOI:10.1016/j.psychres.2018.10.062
Adhikara IM, *Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata K, Emoto N
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.
Biochem Biophys Res Commun. , 2017.
Brew N, Nakamura S, Hale, N. Azhan, A., Davies, G. I., Nitsos, I., Miller, S. L., Walker, D. W., Wong, F. Y.
Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia.
Pediatr Res 83(3):442-450, 2018. DOI:10.1038/s41390-018-0045-5
Yamauchi Y., Itoh S. et al.
HipOP mesenchymal population has high potential for repairing injured peripheral nerves.
J Cell Biochem. 119(6):4836-4844, 2018. DOI:10.1002/jcb.26684
Takeuchi Y., Kito A. et al.
Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling.
Exp. Cell Res. 371(2):417-425, 2018. DOI:10.1016/j.yexcr.2018.09.002
Tainaka K, Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T, Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A, Ueda HR.
Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.
Cell Rep. 24:2196-2210, 2018. DOI:10.1016/j.celrep.2018.07.056
Shiori Miura, Yoshitaka Maeda, Jun Miyamoto, Ena Nakatsukasa, Nobuyoshi Fujisawa, Miki Miwa, Katsuki Nakamura, Kenji Sakimura and Toshikuni Sasaoka
Generation of functional oocytes of common marmoset by xeno-transplantation of ovarian tissue.
Proceedings of International Symposium on Animal Production and Conservation for Sustainable Development 2018 :31-33, 2018.
Michael S Nahorski, Sateesh Maddirevula, Ryosuke Ishimura, Saud Alsahli, Angela Brady, Anaïs Begemann, Tsunehiro Mizushima, Francisco J. Guzmán-Vega, Miki Obata, Yoshinobu Ichimura, Hessa S Alsaif, Shams Anazi, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Dorota Monies, Mohamed Abouelhoda, Brian F Meyer, Majid Alfadhel, Wafa Eyaid, Markus Zweier Katharina Steindl, Anita Rauch, Stefan T. Arold, *C Geoffrey Woods, *Masaaki Komatsu, *Fowzan S Alkuraya.
Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.
Brain 141:1934-1945, 2018. DOI:10.1093/brain/awy135
Ichimura Y, Komatsu M.
Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.
Front Oncol. 8, 2018. DOI:10.3389/fonc.2018.00210
Zhou L, Hossain MI, Yamazaki M, Abe M, Natsume R, Konno K, Kageyama S, Komatsu M, Watanabe M, Sakimura K, Takebayashi H.
Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype.
J Neurochem. 147:557-572, 2018. DOI:10.1111/jnc.14591
Sánchez-Martín P, Komatsu M.
p62/SQSTM1 - steering the cell through health and disease.
J Cell Sci. 131, 2018. DOI:10.1242/jcs.222836
Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Nameta M, Zhang L, Iwakura Y, Nawa H, Higuchi M, Komatsu M, Fujii M.
USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis.
iScience. 9:433-450, 2018. DOI:10.1016/j.isci.2018.11.006
Sánchez-Martín P, Saito T, Komatsu M.
p62/SQSTM1: 'Jack of all trades' in health and cancer.
FEBS J. , 2018. DOI:10.1111/febs.14712
Someya, M. and Ogawa, H.
Multisensory enhancement of burst activity in an insect auditory neuron.
J Neurophysiol. 120:139-148., 2018. DOI:10.1152/jn.00798.2017
Iwatani Y, Ogawa, H, Shidara H, Sakura M, Sato T, Hojo MK, Honma A, Tsurui K
Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals.
Advanced Robotics in press, 2019.
Tatsunori Nishimura, Asuka Nakata, Xiaoxi Chen, Kurumi Nishi, Makiko Meguro-Horike, Soichiro Sasaki, Kenji Kita, Shin-ichi Horike, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Takahiko Murayama, Susumu Kohno, Chiaki Takahashi, Naofumi Mukaida, Seiji Yano, Tomoyoshi Soga, Arinobu Tojo, Noriko Gotoh
Mthfd2の研究.
Oncogene in press, 2018. DOI:10.1038/s41388-018-0589-1
Ng IK, Lee J, Ng C, Kosmo B, Chiu L, Seah E, Mok MMH, Tan K, Osato M, Chng WJ, Yan B, Tan LK.
Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation.
Biomark Res. 6:16, 2018. DOI:10.1186/s40364-018-0130-2
Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
Systematic review of pre-clinical chronic myeloid leukaemia.
Int J Hematol. 108(5):465-484, 2018. DOI:10.1007/s12185-018-2528-x
Koide H, Shiga A, Komai E, Yamato A, Fujimoto M, Tamura A, Kono T, Nakayama A, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Suzuki S, Takeda Y, Shibuya M, Nishioka H, Yamada S, Inoshita N, Ishiwatari N, Horiguchi K, Yokote K, Tanaka T.
Prednisolone-responsive Postpartum IgG4-related Hypophysitis.
Intern Med. 57(3):367-375, 2018. DOI:10.2169/internalmedicine.8446-16
Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women: Chiba bone survey.
Endocr J. 65(2):193-202, 2018. DOI:10.1507/endocrj.EJ17-0331
Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Miyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T.
Glucagonoma With Necrolytic Migratory Erythema: Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.
J Clin Endocrinol Metab. 103(7):2417-2423, 2018. DOI:10.1210/jc.2017-02646
Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi Y, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T.
p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adipocytes and cancer cells.
Proc Natl Acad Sci U S A. 115(33):8370-8375, 2018. DOI:10.1073/pnas.1804243115
Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
Resting-state functional connectivity analysis of the mouse brain using intrinsic optical signal imaging of cerebral blood volume dynamics.
Physiological Measurement 39:054003, 2018. DOI:10.1088/1361-6579/aac033
外川龍之介, 奥畑大悟, 吉田侑冬，中尾光之, 片山統裕
眼位・瞳孔径変動を考慮した内因性光信号イメージングに基づく覚醒時マウス脳視野地図の推定.
生体医工学 in press, 2018.
Maeda A, Nishino T, Matsuzaki R, Yokoyama A, Suga H, Yagi T, Konishi H.
Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling.
Biochim Biophys Acta Mol Cell Res. 1866:285-295, 2018. DOI:10.1016/j.bbamcr.2018.11.009
Kikuchi K, Kozuka-Hata H, Oyama M, Seiki M & Koshikawa N
Identification of proteolytic cleavage sites of EphA2 by membrane type-1 matrix metalloproteinase on the surface of cancer cells.
Methods in Molecular Biology 1731:29-37, 2018. DOI:10.1007/978-1-4939-7595-2_3
Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ.
Study on the tumor-induced angiogenesis using mathematical models.
Cancer Sci. 109:15-23, 2018. DOI:10.1111/cas.13395
Takahashi Y, Hamasaki M, Aoki M, Koga K, Koshikawa N, Miyamoto S, Nabeshima K.
Activated EphA2 processing by MT1-MMP is involved in malignant transformation of ovarian tumours in vivo.
Anticancer Res 38:4257-4266, 2018. DOI:10.21873/anticanres.12722
Okumura K, Saito M, and Wakabayashi Y.
The role of PTH in mouse skin tumorigenesis.
Integrative Cancer Science and Therapeutics 5:2, 2018. DOI:10.15761/ICST.1000271
Aoto Y, Okumura K, Hachiya T, Hase S, Sato K, Wakabayashi Y, Ishikawa F and Sakakibara Y.
Prospective study of the tumorigenesis process with an experimental carcinogenesis model.
Sci. Rep. 8(1):12994, 2018. DOI:10.1038/s41598-018-31349-x
Huizi Li, Aya Sugyo, Atsushi Tsuji, Yukie Morokoshi, Katsuyuki Minegishi, Kotaro Nagatsu, Hiroaki Kanda, Yosuke Harada, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Tatsuya Higashi, Sumitaka Hasegawa
α-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibody against frizzled homolog 10.
Cancer Sci. 109(7):2302-2309, 2018. DOI:10.1111/cas.13636
Noguchi K, Konno M, Eguchi H, Kawamoto K, Mukai R, Nishida N, Koseki J, Wada H, Akita H, Satoh T, Marubashi S, Nagano H, Doki Y, Mori M, Ishii H.
c-Met affects gemcitabine resistance during carcinogenesis in a mouse model of pancreatic cancer.
Oncol Lett 16(2):1892-1898, 2018. DOI:10.3892/ol.2018.8793
Takeuchi E, Ito-Ishida A, Yuzaki M, Yanagihara D.
Improvement of cerebellar ataxic gait by injecting Cbln1 into the cerebellum of cbln1-null mice.
Sci. Rep. 8(1):6184, 2018. DOI:10.1038/s41598-018-24490-0
Ito-Ishida A, Yamalanchili HK, Shao Y, Baker SA, Heckman LD, Lavery LA, Kim JY, Lombardi LM, Sun Y, Liu Z, Zoghbi HY.
Genome-wide distribution of linker histone H1.0 is independent of MeCP2.
Nature Neuroscience 21(6):794-798, 2018. DOI:10.1038/s41593-018-0155-8
Aoto Y, Okumura K, Hachiya T, Hase S, Wakabayashi Y, Ishikawa F, Sakakibara Y.
Time-Series Analysis of Tumorigenesis in a Murine Skin Carcinogenesis Model.
Sci. Rep. 8(1):12994, 2018. DOI:10.1038/s41598-018-31349-x
Zhang Y, Nakano D, Guan Y, Hitomi H, Masaki T, Kobara H, Sugaya Y, Nishiyama A.
A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice.
Kidney Int. 94(3):524-535., 2018. DOI:10.1016/j.kint.2018.05.002
Miyazawa, Y., Takahashi, Y., Watabe, A.M. and Kato F.
Predominant synaptic potentiation and activation of the right central amygdala are independent of bilateral paracrachial activation in the hemilateral trigeminal inflammatory pain model of rats.
Molecular Pain :14:1744806918807102, 2018. DOI:10.1177/1744806918807102
Nagase, M., Mikami, K., and Watabe, A.M.# (#責任著者)
Parabrachial-to-amygdala control of aversive learning.
Current Opinion in Behavioral Sciences in press, 2019.
Futakuchi M, Nitanda T, Ando S, Matsumoto H, Yoshimoto E, Fukamachi K, Suzui M
Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment.
Int J Mol Sci 19（3）, 2018. DOI:10.3390/ijms19030888
Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H
Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes.
Chem Res Toxicol 31（10）:1025-1031, 2018. DOI:10.1021/acs.chemrestox.8b00067
Jinnai, W. Nakamura, S. Koyano, K. Yamato, S. Wakabayashi, T. Htun, Y. Nakao, Y. Iwase, T. Nakamura, M. Yasuda, S. Ueno, M. Miki, T.Kusaka T
Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglets.
Brain Dev 40(8):649-661, 2018. DOI:10.1016/j.braindev.2018.04.010

2017年度

Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI.
Thymidine Catabolism as a Metabolic Strategy for Cancer Survival.
Cell Rep. 19:1313-1321, 2017. DOI:10.1016/j.celrep.2017.04.061
Furukawa T, Tabata S, Yamamoto M, Kawahara K, Shinsato Y, Minami K, Shimokawa M, Akiyama SI
Thymidine phosphorylase in cancer aggressiveness and chemoresistance.
Pharmacol Research 132:15-20, 2018. DOI:10.1016/j.phrs.2018.03.019
河原康一、古川龍彦
核小体によるp53制御とがん治療薬開発の新展開.
実験医学 35:2365-2367, 2017.
Yuichiro Yoneoka, Junichi Yoshimura, Masayasu Okada, Yukihiko Fujii:
Perifocal Inflammatory Reaction with Volume Fluctuation Caused by Diagnostic Radiation-Induced Reduction in Germinoma Makes Histological Diagnosis Difficult despite Its Disappearance following Treatment: A Significant Pitfall and Countermeasures to It.
Pediatr Neurosurg. 52:87-92, 2017. DOI:10.1159/000450583
Yuichiro Yoneoka, Junichi Yoshimura, Masakazu Sano, Masayasu Okada, Akiyoshi Kakita, Yukihiko Fujii
Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement.
Pediatr Neurosurg. 53(1):49-54, 2017. DOI:10.1159/000480021
Hideko Ohno, Yuichiro Yoneoka, Shinya Jinguji, Naoto Watanabe, Masayasu Okada, Yukihiko Fujii
Has acromegaly been diagnosed earlier?.
J Clin Neurosci. 48:138-142, 2017. DOI:10.1016/j.jocn.2017.10.086
Yuichiro Yoneoka, Masayasu Okada, Naoto Watanabe, Satoru Aoki, Akiyoshi Kakita, Yukihiko Fujii
Ectopic pituitary null cell adenoma arising from the infundibulum in the third ventricle: A successful endonasal transsphenoidal resection after long-term follow-up MR imaging – A technical note.
Interdisciplinary Neurosurgery: Advanced Techniques and Case Management 10:122-125, 2017. DOI:10.1016/j.inat.2017.08.004
岡田正康
軸索再生に対するGAP-43の機能解明:GAP-43 (Ser96)のリン酸化は軸索再生の分子マーカーとなる.
新潟医学会雑誌 130(7):405-419, 2016.
Manabu Natsumeda, Kunio Motohashi, Hironaka Igarashi, Takanori Nozawa, Hideaki Abe, Yoshihiro Tsukamoto, Ryosuke Ogura, Masayasu Okada, Tsutomu Kobayashi, Hiroshi Aoki, Hitoshi Takahashi, Akiyoshi Kakita, Koichiro Okamoto, Tsutomu Nakada, Yukihiko Fujii
Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy.
Neurosurg Rev 41（2）:641-647, 2018. DOI:10.1007/s10143-017-0908-y
Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K*.
Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.
Exp Neurol 293:1-12, 2017. DOI:10.1016/j.expneurol.2017.03.009
Park S, Mori R, Shimokawa I
The fat regulator neuropeptide Y and caloric restriction.
Aging (Albany NY) 9(11):2243-2244, 2017. DOI:10.18632/aging.101338
Hattori M, Shimizu A, Oikawa D, Kamei K, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Tokunaga F, Ishikawa O.
Endoplasmic reticulum stress in the pathogenesis of pretibial dystrophic epidermolysis bullosa.
British Journal of Dermatology 177(4):e92-e93, 2017. DOI:10.1111/bjd.15342
Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S.
Iron and thiol redox signaling in cancer.
Free Radical Biology & Medicine 108:610-626, 2017. DOI:10.1016/j.freeradbiomed.2017.04.024
Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon S, Fulda S, Gascon S, Hatzios SK, Kagan V, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat G, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti F, Torti S, Toyokuni S, Woerpel KA, Zhang DD.
Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease.
Cell 171:273-285, 2017. DOI:10.1016/j.cell.2017.09.021
Asami Kawasak, Masayasu Okada, Atsushi Tamada, Shujiro Okuda, Motohiro Nozumi, Yasuyuki Ito, Daiki Kobayashi, Tokiwa Yamasaki, Ryo Yokoyama, Takeshi Shibata, Hiroshi Nishina, Yutaka Yoshida, Yukihiko Fujii, Kosei Takeuchi, Michihiro Igarashi
Growth Cone Phosphoproteomics Reveals that GAP-43 Phosphorylated by JNK Is a Marker of Axon Growth and Regeneration.
iScience 4:190-203, 2018. DOI:10.1016/j.isci.2018.05.019
Michihiro Igarashi, Motohiro Nozumi, Ling-Gang Wu, Francesca Cella Zanacchi, István Katona, László Barna, Pingyong Xu, Mingshu Zhang, Fudong Xue and Edward Boyden
New observations in neuroscience using superresolution microscopy.
J Neurosci 38(44):9459-9467, 2018. DOI:10.1523/JNEUROSCI.1678-18.2018
井口善生
オペラント条件づけ―基礎理論を学ぶ.
臨床心理学 (もっと知りたいあなたのための認知行動療法ガイド) 18:7-11, 2018.
Arakawa, H., & Iguchi, Y.
Ethological and multi-behavioral analysis of learning and memory performance in laboratory rodent models.
Neurosci Res. 135:1-12, 2018. DOI:10.1016/j.neures.2018.02.001
Lucas BA, Lavi E, Shiue L, Cho H, Katzman S, Miyoshi K, Siomi MC, Carmel L, Ares M Jr, Maquat LE.
Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay.
Proc Natl Acad Sci U S A. 115:968-973, 2018. DOI:10.1073/pnas.1715531115
Nishida KM, Sakakibara K, Iwasaki YW, Yamada H, Murakami R, Murota Y, Kawamura T, Kodama T, Siomi H, Siomi MC.
Hierarchical roles of mitochondrial Papi and Zucchini in Bombyx germline piRNA biogenesis.
Nature 555:260-264, 2018. DOI:10.1038/nature25788
Mito M., Kadota M., Tanaka K., Furuta Y., Abe K., Iwasaki S.*, and Nakagawa S.
Cell-type specific survey of epigenetic modifications by tandem chromatin immunoprecipitation sequencing.
Sci. Rep. 8:1143, 2018. DOI:10.1038/s41598-018-19494-9
Naruse K., Matsuura-Suzuki E., Watanabe M., Iwasaki S.*, Tomari Y.
In vitro reconstitution of chaperone-mediated human RISC assembly.
RNA 24(1):6-11, 2018. DOI:10.1261/rna.063891.117
Tsutomu Fukuda, Teppei Umeki, Keiji Tokushima, Gao Xiang, Yuki Yoshida, Fumito Ishibashi, Yusuke Oku, Naoyuki Nishiya, Yoshimasa Uehara, Masatomo Iwao
Design, synthesis, and evaluation of A-ring-modified lamellarin N analogues as noncovalent inhibitors of the EGFR T790M/L858R mutant.
Bioorganic and Medicinal Chemistry 25 (24):6563-6580, 2017. DOI:10.1016/j.bmc.2017.10.030 ＊
Kuriyama Y, Hattori M, Mitsui T, Nakano H, Oikawa D, Tokunaga F, Ishikawa O, Shimizu A.
Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency.
J Dermatol. 45:e108-e109, 2018. DOI:10.1111/1346-8138.14149
Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H
Calmodulin kinases: essential regulators in health and disease.
J Neurochem. 141(6):808-818, 2017. DOI:10.1111/jnc.14020
Kwon T*, Sakamoto M* (Co-first author), Peterka DS, Yuste R
Attenuation of Synaptic Potentials in Dendritc Spines.
Cell Rep. 20(5):1100-1110, 2017. DOI:10.1016/j.celrep.2017.07.012
Yamaguchi N, Nakayama Y, Yamaguchi N
Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6.
J Biol Chem. 292(20):8136-8148, 2017. DOI:10.1074/jbc.M116.763276
Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N
Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).
Biochem Biophys Res Commun. 490(3):1045-1051, 2017. DOI:10.1016/j.bbrc.2017.06.163
Anzai E, Hirata K, Shibazaki M, Yamada C, Morii M, Honda T, Yamaguchi N, Yamaguchi N
FOXA1 Induces E-Cadherin Expression at the Protein Level via Suppression of Slug in Epithelial Breast Cancer Cells.
Biol Pharm Bull. 40(9):1483-1489, 2017. DOI:10.1248/bpb.b17-00307
Takakura Y, Yamaguchi N, Honda T, Morii M, Yuki R, Nakayama Y, Yamaguchi N
The Truncated Isoform of the Receptor Tyrosine Kinase ALK Generated by Alternative Transcription Initiation (ALK(ATI)) Induces Chromatin Structural Changes in the Nucleus in a Kinase Activity-Dependent Manner.
Biol Pharm Bull. 40(11):1968-1975, 2017. DOI:10.1248/bpb.b17-00548
Honda T, Morii M, Nakayama Y, Suzuki K, Yamaguchi N, Yamaguchi N
v-Src-driven transformation is due to chromosome abnormalities but not Src-mediated growth signaling.
Sci. Rep 8:1063, 2017. DOI:10.1038/s41598-018-19599-1
Okamoto A, Morinaga T, Yamaguchi N, Yamaguchi N
Golgi Distribution of Lyn to Caveolin- and Giantin-Positive cis-Golgi Membranes and the Caveolin-Negative, TGN46-Positive trans-Golgi Network.
Biol Pharm Bull. 41(1):142-146, 2017. DOI:10.1248/bpb.b17-00681
Hozumi J, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Kusakabe Y, Yamada Y
Resistin Is a Novel Marker for Postoperative Pain Intensity.
Anesthesia & Analgesia in press, 2018. DOI:10.1213/ANE.0000000000003363
Nakamura T, Okabe S, Yoshida H, Iida K, Ma Y, Sasaki S, Yamori T, Shin-Ya K, Nakano I, Nagasawa K, Seimiya H.
Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole.
Sci. Rep. 7:e3605, 2017. DOI:10.1038/s41598-017-03785-8
Kawada, M., Inoue, H., Kajikawa, M., Sugiura, M., Sakamoto, S., Urano, S., Karasawa, C., Usami, I., Futakuchi, M., Masuda, T.
A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo.
Sci. Rep. 7:40400, 2017. DOI:10.1038/srep40400
Ishisaka N, Shimano S, Miura T, Motomura K, Horii M, Imanaga H, Kishimoto J, Kaneda Y, Sora I, Kanba S.
Neurocognitive profile of euthymic Japanese patients with bipolar disorder.
Psychiatry Clin Neurosci. 71(6):373-382, 2017. DOI:10.1111/pcn.12500
Shimmyo N, Hishimoto A, Otsuka I, Okazaki S, Boku S, Mouri K, Horai T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
Association study of MIF promoter polymorphisms with suicide completers in the Japanese population.
Neuropsychiatr Dis Treat. 13:899-908, 2017. DOI:10.2147/NDT.S130855
Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Inoue E, Igeta H, Otsuka I, Shibuya M, Egawa J, Sora I, Someya T.
Rare FBXO18 variations and risk of schizophrenia: Whole-exome sequencing in two parent-affected offspring trios followed by resequencing and case-control studies.
Psychiatry Clin Neurosci. 71(8):562-568, 2017. DOI:10.1111/pcn.12526
Otsuka I, Izumi T, Boku S, Kimura A, Zhang Y, Mouri K, Okazaki S, Shiroiwa K, Takahashi M, Ueno Y, Shirakawa O, Sora I, Hishimoto A.
Aberrant telomere length and mitochondrial DNA copy number in suicide completers.
Sci. Rep 7(1):3176, 2017. DOI:10.1038/s41598-017-03599-8
Hoya S, Watanabe Y, Hishimoto A, Nunokawa A, Kaneko N, Muratake T, Shinmyo N, Otsuka I, Okuda S, Inoue E, Igeta H, Shibuya M, Egawa J, Orime N, Sora I, Someya T.
Rare PDCD11 variations are not associated with risk of schizophrenia in Japan.
Psychiatry Clin Neurosci. 71(11):780-788, 2017. DOI:10.1111/pcn.12549
Luo H, Hasegawa K, Liu MS, Song W-J.
Comparison of the Upper Marginal Neurons of Cortical Layer 2 with Layer 2/3 Pyramidal Neurons in Mouse Temporal Cortex.
Front Neuroanat 11:115, 2017. DOI:10.3389/fnana.2017.00115
Nishimura M, Takemoto M, Song W-J.
Organization of auditory areas in the superior temporal gyrus of marmoset monkeys revealed by real-time optical imaging.
Brain Structure and Function in press:1599-1614, 2018. DOI:10.1007/s00429-017-1574-0
Meikui Wu,Makoto Takemoto,Huan Luo,Jian-Jun Xu,Mei-Hong Lu,Masaki Kameyama,Toru Takumi,Wen-Jie Song.
A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1.
Eur J Pharmacology 824:99-107, 2018. DOI:10.1016/j.ejphar.2018.02.013
Ohta S, Kawakami Y, Okano H
MIF: functions in brain and glioblastoma.
Oncotarget 8(29):46706-46707, 2017. DOI:10.18632/oncotarget.18489
Naoaki Sakata, Yohko Yamaguchi, Yu Chen, Masayuki Shimoda, Gumpei Yoshimatsu, Michiaki Unno, Shoichiro Sumi, Rieko Ohki.
Pleckstrin homology-like domain family A, member 3 (PHLDA3) deficiency improves islets engraftment through the suppression of hypoxic damage.
PLoS One. 12(11):e0187927, 2017. DOI:10.1371/journal.pone.0187927
Yachie N., Robotic Biology Consortium (incl. Nakayama KI.), Natsume T.
Robotic crowd biology with Maholo LabDroids.
Nature Biotechnol. 35:310-2, 2017. DOI:10.1038/nbt.3758
Zhang S., Chen Q., Liu Q., Li Y., Sun X., Hong L., Ji S., Liu C., Geng J., Zhang W., Lu Z., Yin ZY., Zeng Y., Lin KH., Wu Q., Li Q., Nakayama K., Nakayama KI., Deng X., Johnson RL., Zhu L., Gao D., Chen L., Zhou D.
Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2.
Cancer Cell 31:669-84, 2017. DOI:10.1016/j.ccell.2017.04.004
Muto Y., Nishiyama M., Nita A., Moroishi T., Nakayama KI.
Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
Nature Commun. 8:16114, 2017. DOI:10.1038/ncomms16114
Yaguchi H., Yabe I., Takahashi H., Watanabe M., Nomura T., Kano T., Matsumoto M., Nakayama KI., Watanabe M., Hatakeyama S.
Sez6l2 regulates phosphorylation of ADD and neuritogenesis.
Biochem Biophys Res Commun. 494:234-41, 2017. DOI:10.1016/j.bbrc.2017.10.047
Fukushima H., Shimizu K., Watahiki A., Hoshikawa S., Kosho T., Oba D., Sakano S., Arakaki M., Yamada A., Nagashima K., Okabe K., Fukumoto S., Jimi E., Bigas A., Nakayama KI., Nakayama K., Aoki Y., Wei W., Inuzuka H.
NOTCH2 Hajdu-Cheney mutations escape SCFFBW7-dependent proteolysis to promote osteoporosis.
Mol. Cell 68:645-58.e5, 2017. DOI:10.1016/j.molcel.2017.10.018
Yonehara R., Nada S., Nakai T., Nakai M., Kitamura A., Ogawa A., Nakatsumi H., Nakayama KI., Li S., Standley DM., Yamashita E., Nakagawa A., Okada M.
Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nature Commun. 8:1625, 2017. DOI:10.1038/s41467-017-01762-3
Nakatsumi H., Matsumoto M., Nakayama KI.
Noncanonical pathway for regulation of CCL2 expression by an mTORC1-FOXK1 axis promotes recruitment of tumor-associated macrophages.
Cell Rep. 21:2471-86, 2017. DOI:10.1016/j.celrep.2017.11.014
Hagihara H., Catts VS., Katayama Y., Shoji H., Takagi T., Huang FL., Nakao A., Mori Y., Huang KP., Ishii S., Graef IA., Nakayama KI., Shannon Weickert C., Miyakawa T.
Decreased brain pH as a shared endophenotype of psychiatric disorders.
Neuropsychopharmacology 43:459-68, 2018. DOI:10.1038/npp.2017.167
Sakai E., Nakayama M., Oshima H., Kouyama Y., Niida A., Fujii S., Ochiai A., Nakayama KI., Mimori K., Suzuki Y., Hong CP., Ock CY., Kim SJ., Oshima M.
Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.
Cancer Res. in press, 2018. DOI:10.1158/0008-5472.CAN-17-3303
Mikamo M., Kitagawa K., Sakai S., Uchida C., Ohhata T., Nishimoto K., Niida H., Suzuki S., Nakayama KI., Inui N., Suda T., Kitagawa M.
Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis.
J Mol Sci. 19 in press, 2018. DOI:10.3390/ijms19020474
Nakayama S., Yumimoto K., Kawamura A., Nakayama KI.
Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.
J Biol Chem. in press, 2018. DOI:10.1074/jbc.RA117.000741
Matsumoto M.,. Nakayama KI
The promise of targeted proteomics for quantitative network biology.
Curr. Opin. Biotechnol. 54:88-97, 2018. DOI:10.1016/j.copbio.2018.02.014
Hashimoto Y., Shirane M., Nakayama KI.
TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation.
Genes Cells 23(6):418-434, 2018. DOI:10.1111/gtc.12583
Kano M, Watanabe T
Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease.
F1000Research 6:416, 2017. DOI:10.12688/f1000research.10485.1
Aikawa T, Watanabe T, Miyazaki T, Mikuni T, Wakamori M, Sakurai M, Aizawa H, Ishizu N, Watanabe M, Kano M, Mizusawa H, Watase K.
Alternative splicing in the C-terminal tail of Cav2.1 is essential for preventing a neurological disease in mice.
Human Molecular Genetics 26(16):3094-3104, 2017. DOI:10.1093/hmg/ddx193
Watanabe T, Shimazaki T, Oda Y.
Coordinated expression of two types of low-threshold K+ channels establishes unique single-spiking of Mauthner cells among segmentally homologous neurons in the zebrafish hindbrain.
eNeuro 1523:0249-17, 2017. DOI:10.1523/ENEURO.0249-17.2017
Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M.
Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum.
Neuron 97(4):796-805, 2018. DOI:10.1016/j.neuron.2018.01.018
Hanaki, Y., Kikumori, M., Tokuda, H., Okamura, M., Dan, S., Adachi, N., Saito, N., Yanagita, R. C., Irie, K.
Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities.
Molecules 22(4):e631, 2017. DOI:10.3390/molecules22040631
Katow H, Kanaya T, Ogawa T, Egawa R, Yawo H.
Regulation of axon arborization pattern in the developing chick ciliary ganglion: Possible involvement of caspase 3.
Dev Growth Differ 59(3):115-128, 2017. DOI:10.1111/dgd.12346
Tsunoda SP, Prigge M, Abe-Yoshizumi R, Inoue K, Kozaki Y, Ishizuka T, Yawo H, Yizhar O, Kandori H.
Functional characterization of sodium-pumping rhodopsins with different pumping properties.
PLoS One. 12(7):e0179232, 2017. DOI:10.1371/journal.pone.0179232
Asano T, Ishizuka T, Yawo H.
Myogenic Maturation by Optical-Training in Cultured Skeletal Muscle Cells.
Methods Mol Biol. 1668:135-145, 2017. DOI:10.1007/978-1-4939-7283-8_10
Abe K, Yawo H.
Optogenetic conditioning of paradigm and pattern discrimination in the rat somatosensory system.
PLoS One. 12(12):e0189439, 2017. DOI:10.1371/journal.pone.0189439
Tashima R, Koga K, Sekine M, Kanehisa K, Kohro Y, Tominaga K, Matsushita K, Tozaki-Saitoh H, Fukazawa Y, Inoue K, Yawo H, Furue H, Tsuda M.
Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats.
eNeuro 5(1):ENEURO.0450-17, 2018. DOI:10.1523/ENEURO.0450-17.2018
Okitsu T, Matsuyama T, Yamashita T, Ishizuka T, Yawo H, Imamoto Y, Shichida Y, Wada A.
Alternative Formation of Red-Shifted Channelrhodopsins: Noncovalent Incorporation with Retinal-Based Enamine-Type Schiff Bases and Mutated Channelopsin.
Chem Pharm Bull (Tokyo). 28(3):1024-1038, 2017. DOI:10.1248/cpb.c17-00054
Moriguchi S, Ishizuka T, Yabuki Y, Shioda N, Sasaki Y, Tagashira H, Yawo H, Yeh JZ, Sakagami H, Narahashi T, Fukunaga K.
Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy.
Mol Psychiatry. 23(2):211-221, 2018. DOI:10.1038/mp.2016.187
Ushijima T, Fujimoto N, Matsuyama S, Kan-o M, Kiyonari H, Shioi G, Kage Y, Yamasaki S, Takeya R, Sumimoto H.
The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice.
J Biol Chem. 293:148-162, 2018. DOI:10.1074/jbc.M117.813931
Tsutomu Fukuda, Minoru Komure, Gen Onodera, Masanari Kimura, Masatomo Iwao
Synthesis of 4,5-disubstituted pyrano[3,4-b]pyrrol-7(1H)-ones via Sonogashira–Hagihara cross-coupling of N-benzenesulfonyl-3-bromo-1H-pyrrole-2-carboxylate and subsequent iodine-mediated cyclization.
Heterocycles 97 in press, 2018. DOI:10.3987/COM-18-S(T)68
Ali MAE， Fuse K， Tadokoro Y， Hoshii T， Ueno M， Kobayashi M， Nomura N， Vu HT， Peng H， Hegazy AM， Masuko M， Sone H， Arai F， Tajima A， Hirao A.
Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression.
Sci. Rep. :11442, 2017. DOI:10.1038/s41598-017-11909-3
Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi N, Hirao A
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cell Stem Cell 22:713-725, 2018. DOI:10.1016/j.stem.2018.04.002
Goyama S and Kitamura T.
Epigenetics in Normal and Malignant Hematopoiesis: An Overview and Update 2017.
Cancer Sci. 108(4):553-562, 2017. DOI:10.1111/cas.13168
Kitamura T.
ASXL1 mutations gain a function.
Blood 131(3):274-275, 2018. DOI:10.1182/blood-2017-12-816595
Nagase R, Inoue D, Pastore A, Fujino T, Hou HA, Yamasaki N, Goyama S, Saika M, Kanai A, Sera Y, Horikawa S, Ota Y, Asada S, Hayashi Y, Kawabata KC, Takeda R, Tien HF, Honda H, Abdel-Wahab O, Kitamura T.
Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.
J Exp Med. 215(6):1729-1747, 2018. DOI:10.1084/jem.20171151
Inoue D, Fujino T, Sheridan P, Zhang Yz, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata KC, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang FC, Oyama M, Kitamura T
A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.
Leukemia 32(6):1327-1337, 2018. DOI:10.1038/s41375-018-0083-3
Itoh M, Kaizuka T, Hayashi T
Evolutionary acquisition and divergence of vertebrate HCN2 palmitoylation.
Neurotransmitter 4:e1603, 2017. DOI:10.14800/nt.1603
Hayashi T
Conservation and phylogenetic stepwise changes of aquaporin (AQP) 4 palmitoylation in vertebrate evolution.
Neurotransmitter 4:e1608, 2017. DOI:10.14800/nt.1608
Kaizuka T, Hayashi T
Comparative analysis of palmitoylation sites of serotonin (5-HT) receptors in vertebrates.
Neuropsychopharmacology Reports 38:75-85, 2018. DOI:10.1002/npr2.12011
Kusuoka O, Fujiwara-Tani R, Nakashima C, Fujii K, Ohmori H, Mori T, Kishi S, Miyagawa Y, Goto K, Kawahara I, Kuniyasu H
Intermittent calorie restriction enhances epithelial-mesenchymal transition through alteration of energy metabolism in a mouse tumor model.
International Journal of Oncology 52:413-423, 2018. DOI:10.3892/ijo.2017.4229
Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T, Kuniyasu H.
Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma.
Histopathology 70(4):539-548, 2017. DOI:10.1111/his.13097
Kishi S, Fujiwara-Tani R, Luo Y, Kawahara I, Goto K, Fujii K, Ohmori H, Nakashima C, Sasaki T, Kuniyasu H
Pro-metastatic signaling of elaidic acid, a trans fatty acid, is associated with lipid rafts.
Oncol Lett 15:4423-4426, 2018. DOI:10.3892/ol.2018.7817
Hashimoto Y, Fukasawa M, Kuniyasu H, Yagi K, Kondoh M
Claudin-targeted drug development using anti-claudin monoclonal antibodies to treat hepatitis and cancer.
Annals of New York Academy of Sciences 1397(1):5-16, 2017. DOI:10.1111/nyas.13337
Fujii K, Luo Y, Nishiguchi Y, Fujiwara R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H
Pro-metastatic intracellular signaling of elaidic acid, a trans fatty acid.
Int J Oncol 50(1):85-92, 2017. DOI:10.3892/ijo.2016.3797
Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T, Kuniyasu H
Elaidic acid, a trans fatty acid, enhances the metastasis of colorectal cancer cells.
Pathobiology 84(3):144-151, 2017. DOI:10.1159/000449205
Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Fujiwara R, Kadochi Y, Mori S, Kuniyasu H
Fatty acids inhibit anti-cancer effect of 5-fluorouracil in mouse cancer cell lines.
Oncol Lett 14(1):681-686, 2017. DOI:10.3892/ol.2017.6190
Mori S, Kadochi Y, Luo Y, Fujiwara-Tani R, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
Proton pump inhibitor induces-collagen expression in colonocytes is associated with collagenous colitis.
World Journal of Gastroentrology 23(9):1586-1593, 2017. DOI:10.3748/wjg.v23.i9.1586
Kadochi Y, Mori S, Fujiwara-Tani R, Luo Y, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed proliferation of CT26 mouse colon cancer cells.
Oncol Lett 14(1):673-680, 2017. DOI:10.3892/ol.2017.6195
Kawahara I, Mori T, Goto K, Fujii K, Ohmori H, Fujiwara-Tani R, Kuniyasu H
Fatty acids induce stemness in the stromal cells of a CT26 mouse tumor model.
Pathobiology 84(5):237-242, 2017. DOI:10.1159/000471854
Mukai S, Oue N, Oshima T, Imai T, Sekino Y, Honma R, Sakamoto N, Sentani K, Kuniyasu H, Egi H, Tanabe K, Yoshida K, Ohdan H, Yasui W
Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer.
J. Pathol. 243(1):100-110, 2017. DOI:10.1002/path.4931
Kurihara M, Sasahira T, Nakahiro, Nakashima C, Kuniyasu H, Kirita T
Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma.
J Clin Pathol 71(5):436-441, 2018. DOI:10.1136/jclinpath-2017-204770
Nakashima C, Kishi S, Fujiwara-Tani R, Luo Y, Kawahara I, Goto K, Fujii K, Ohmori H, Kuniyasu H
Expression of the long-chain fatty acid receptor GPR40 was associated with cancer progression in colorectal cancer.
Oncol Lett 15(6):8641-8646, 2018. DOI:10.3892/ol.2018.8383
Soma S, Saiki A, Yoshida J, Ríos A, Kawabata M, Sakai Y, Isomura Y
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J Neurosci 37(45):10904-10916, 2017. DOI:10.1523/JNEUROSCI.1188-17.2017
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SEVEN FAMILIAL DYSALBUMINEMIC HYPERTHYROXINEMIA CASES IN THREE UNRELATED JAPANESE FAMILIES AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ANALYSIS OF THE THYROXINE BINDING PROFILE.
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Yu Okazawa, Kosuke Mizukoshi, Yu Koyama, Shoki Okubo, Hiromitsu Komiyama, Yutaka Kojima, Michitoshi Goto, Sonoko Habu, Okio Hino, Kazuhiro Sakamoto* and Akira Orimo*
High-sensitivity detection of micrometastases in GFP-labelled colon tumor organoids extracted from patient-derived tumor xenografts.
J Vis Exp. 14:136, 2018. DOI:10.3791/57374
Tomokatsu Omoto, Joo-ri Kim-Kaneyama, Xiao-Feng Lei, Akira Orimo, Koji Ohnishi, Kosuke Yoshihara, Aya Miyauchi, Shuo Li, Lin Gao, Takahiro Umemoto, Junichi Tanaka, Kenta Nakahara, Motohiro Takeya, Fumio Ishida, Shin-ei Kudo, Shogo Haraguchi, Takuro Miyazaki and Akira Miyazaki
The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling.
Oncogene 37(9):1205-1219, 2018. DOI:10.1038/s41388-017-0033-y
Nakaoka HJ, Tanei Z, Hara T, Weng JS, Kanamori A, Hayashi T, Sato H, Orimo A, Otsuji K, Tada K, Morikawa T, Sasaki T, Fukayama M, Seiki M, Murakami Y, Sakamoto T.
Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth.
Oncogenesis. 6:e334, 2017. DOI:10.1038/oncsis.2017.27
Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu X, Takahashi K.
Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.,.
Respir Res. 18:46, 2017. DOI:10.1186/s12931-017-0529-6
Ogura H, Nagatake-Kobayashi Y, Adachi J, Tomonaga T, Fujita N, Katayama R
TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity.
Sci Rep 7(1):5519, 2017. DOI:10.1038/s41598-017-05736-9
Takase S, Kurokawa R, Arai D, Kanto K K, Okino T, Nakao Y, Kushiro T, Yoshida M, Matsumoto K.
A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B.
Sci Rep 7:2002, 2017. DOI:10.1038/s41598-017-02016-4
Yamaguchi N, Shibazaki M, Yamada C,Anzai E, Morii M, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N.
Tyrosine Phosphorylation of the Pioneer Transcription Factor FoxA1 Promotes Activation of Estrogen Signaling.
J Cell Biochem 118:1453-1461, 2017. DOI:10.1002/jcb.25804
Yamaguchi N, Nakayama Y, Yamaguchi N.
Down-regulation of Forkhead Box Protein A1 (FOXA1) Leads to Cancer-stem Cell-like Properties in Tamoxifen-resistant Breast Cancer Cells through Induction of Interleukin-6.
J Biol Chem 292:8136-8148, 2017. DOI:10.1074/jbc.M116.763276
Mori S, Kadochi Y, Luo Y, Fujiwara-Tani R, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis.
World J Gastroenterol 23:1586-1593, 2017. DOI:10.3748/wjg.v23.i9.1586
Fujii K, Luo Y, Fujiwara-Tani R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H.
Pro-metastatic intracellular signaling of the elaidic trans fatty acid.
Int J Oncol 50:85-92, 2017. DOI:10.3892/ijo.2016.3797
Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T, Kuniyasu H.
Elaidic Acid, a Trans-Fatty Acid, Enhances the Metastasis of Colorectal Cancer Cells.
Pathobiology 84:144-151, 2017. DOI:10.1159/000449205
Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Fujiwara R, Kadochi Y, Mori S, Kuniyasu H
Fatty acids inhibit anti-cancer effect of 5-fluorouracil in mouse cancer cell lines.
Oncol Lett 14:681-686, 2017. DOI:10.3892/ol.2017.6190
Kadochi Y, Mori S, Fujiwara-Tani R, Luo Y, Nishiguchi Y, Kishi S, Fujii K, Ohmori H, Kuniyasu H
Remodeling of energy metabolism by a ketone body and medium-chain fatty acid suppressed proliferation of CT26 mouse colon cancer cells.
Oncol Lett 14:673-680, 2017. DOI:10.3892/ol.2017.6195
Shinji Nakamura, Walker DW, Wong FY
Cerebral haemodynamic response to somatosensory stimulation in neonatal lambs.
J. Pathol. 595(17):6007-21, 2017. DOI:10.1113/JP274244
Shinji Nakamura, Walker DW, Wong FY
Cerebral haemodynamic response to somatosensory stimulation in fetal sheep.
J. Pathol. 595(4):1289-1303, 2017. DOI:10.1113/JP273163
Fujikawa J., Takeuchi Y. et al.
Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes.
Cell & Tissue Research 370(3):441-449, 2017. DOI:10.1007/s00441-017-2674-0

2016年度

Moinuddin FM, Shinsato Y, Komatsu M, Mitsuo R, Minami K, Yamamoto M, Kawahara K, Hirano H, Arita K, Furukawa T
ATP7B expression confers multidrug resistance through drug sequestration.
Oncotarget 7:22779-90, 2016. DOI:10.18632/oncotarget.8059
Tanabe K, Shinsato Y, Furukawa T, Kita Y, Hatanaka K, Minami K, Kawahara K, Yamamoto M, Baba K, Mori S, Uchikado Y, Maemura K, Tanimoto A, Natsugoe S
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
Oncotarget 8:6353-6363, 2017. DOI:10.18632/oncotarget.14087
Katamura, T.; Shimizu, T.; Mutoh, Y.; Saito, S.
Synthesis of Tricyclic Benzazocines by Aza-Prins Reaction.
Organic Letters 19(1):266-269, 2017. DOI:10.1021/acs.orglett.6b03577
Doi H, Kitajima Y, Luo L, Yan C, Tateishi S, Ono Y, Urata Y, Goto S, Mori R, Masuzaki H, Shimokawa I, Hirano A, Li TS
Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing.
Sci. Rep 6:18844, 2016. DOI:10.1038/srep18844
Pei W Tanaka K, Huang SC, Xu L, Liu B, Sinclair J, Idol J, Varshney GK, Huang H, Lin S, Nussenblatt RB, Mori R, Burgess SM
Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation.
NPJ Regen Med 1:16013, 2016. DOI:10.1038/npjregenmed.2016.13
Park S, Komatsu T, Kim SE, Tanaka K, Hayashi H, Mori R, Shimokawa I
Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction.
Aging Cell 16(2):339-348, 2016. DOI:10.1111/acel.12558
Saitoh Y, Hamano A, Mochida K, Kakeya A, Uno M, Tsuruyama E, Ichikawa H, Tokunaga F, Utsnomiya A, Watanabe T, Yamaoka S.
A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.
Leukemia 30(3):716-727, 2016. DOI:10.1038/leu.2015.267
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F.
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.
Nature Commun. 7:12547, 2016. DOI:10.1038/ncomms12547
Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue J.
HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.
PLoS Pathogens 13:e100162, 2017. DOI:10.1371/journal.ppat.1006162
Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H.
Reduced SHARPIN and LUBAC formation may contribute to CCl4- or acetaminophen-induced liver cirrhosis in mice.
International Journal of Molecular Sciences 18:326, 2017. DOI:10.3390/ijms18020326
Goto E, Tokunaga F.
Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.
Biochem Biophys Res Commun. 485:152-159, 2017. DOI:10.1016/j.bbrc.2017.02.040
Toyokuni S
Oxidative stress as an iceberg in carcinogenesis and cancer biology.
Arch Biochem Biophys. 595:46-49, 2016. DOI:10.1016/j.abb.2015.11.025
Toyokuni S
The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis-resistance to non-thermal plasma therapy.
Pathology International 66:245-259, 2016. DOI:10.1111/pin.12396
Motohiro Nozumi, Fubito Nakatsu, Kaoru Katoh, Michihiro Igarashi
Coordinated Movement of Vesicles and Actin Bundles during Nerve Growth Revealed by Superresolution Microscopy.
Cell Rep. 18(9):2203-2216, 2017. DOI:10.1016/j.celrep.2017.02.008
Motohiro Nozumi, Michihiro Igarashi
Vesicular movements in the growth cone.
Neurochemistry International 119:71-76, 2018. DOI:10.1016/j.neuint.2017.09.011
Kai Kitamura, Hiroaki Itoh, Kaori Sakurai, Shingo Dan, Masayuki Inoue
Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase.
Journal of the American Chemical Society 140(38):12189-12199, 2018. DOI:10.1021/jacs.8b07339
Shibata N, Kashima M, Ishiko T, Nishimura O, Rouhana L, Misaki K, Yonemura S, Saito K, Siomi H, Siomi MC, Agata K.
Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian.
Dev. Cell 37:226-37., 2016. DOI:10.1016/j.devcel.2016.04.009
Iwasaki YW, Murano K, Ishizu H, Shibuya A, Iyoda Y, Siomi MC, Siomi H, Saito K.
Piwi Modulates Chromatin Accessibility by Regulating Multiple Factors Including Histone H1 to Repress Transposons.
Mol. Cell 63:p1-12, 2016. DOI:10.1016/j.molcel.2016.06.008
Sumiyoshi T, Sato K, Yamamoto H, Iwasaki YW, Siomi H, Siomi MC.
Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells.
Genes Dev. 30:1617-1622., 2016. DOI:10.1101/gad.283929.116
Guida V, Cernilogar FM, Filograna A, De Gregorio R, Ishizu H, Siomi MC, Schotta G, Bellenchi GC, Andrenacci D.
Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.
Genetics 204:631-644, 2016. DOI:10.1534/genetics.116.187922
Matsumoto N, Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, Siomi MC, Nureki O.
Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA.
Cell 167:484-497, 2016. DOI:10.1016/j.cell.2016.09.002
Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, Nureki O.
Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.
Sci. Rep 6:34756 , 2016. DOI:10.1038/srep34756
Sho Wakayama, Shigeki Kiyonaka, Itaru Arai, Wataru Kakegawa, Shinji Matsuda, Keiji Ibata, Yuri L. Nemoto, Akihiro Kusumi, Michisuke Yuzaki & Itaru Hamachi
Chemical labeling for visualizing native AMPA receptors in live neurons.
Nature Commun. 8:e14850, 2017. DOI:10.1038/ncomms14850
Misako Matsushita, Yuhki Nakatake, Itaru Arai, Keiji Ibata, Kazuhisa Kohda, Sravan Goparaju, Miyako Murakami, Miki Sakota, Nana Chikazawa-Nohtomi, Shigeru Ko, Takanori Kanai, Michisuke Yuzaki & Minoru S.H. Ko
Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors.
Biochem Biophys Res Commun. 490:296-301, 2017. DOI:10.1016/j.bbrc.2017.06.039
Gen Shiihashi, Daisuke Ito, Itaru Arai, Yuki Kobayashi, Kanehiro Hayashi, Shintaro Otsuka, Kazunori Nakajima, Michisuke Yuzaki, Shigeyoshi Itohara, Norihiro Suzuki
Dendritic homeostasis disruption in a novel frontotemporal dementia mouse model expressing cytoplasmic fused in sarcoma.
EBioMedicine 24:102-115, 2017. DOI:10.1016/j.ebiom.2017.09.005
Okamoto M, Nakayama Y, Kakihana A, Yuki R, Yamaguchi N, Yamaguchi N
Fyn Accelerates M Phase Progression by Promoting the Assembly of Mitotic Spindle Microtubules.
J Cell Biochem. 117(4):610-623, 2016. DOI:10.1002/jcb.25373
Honda T, Soeda S, Tsuda K, Yamaguchi C, Aoyama K, Morinaga T, Yuki R, Nakayama Y, Yamaguchi N, Yamaguchi N
Protective role for lipid modifications of Src-family kinases against chromosome missegregation.
Sci. Rep 6:38751, 2016. DOI:10.1038/srep38751
Morii M, Kubota S, Honda T, Yuki R, Morinaga T, Kuga T, Tomonaga T, Yamaguchi N, Yamaguchi N
Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530.
J Biol Chem. 292(5):1648-1665, 2017. DOI:10.1074/jbc.M116.753202
Morinaga T, Yanase S, Okamoto A, Yamaguchi N, Yamaguchi N
Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells.
Sci. Rep 7:493, 2017. DOI:10.1038/s41598-017-00538-5
Sumitani M, Nishizawa D, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain.
Pain Medicine 19:348-354, 2018. DOI:10.1093/pm/pnx102
Katsushima K, Natsume A, Ohka F, Shinjo K, Hatanaka A, Ichimura N, Sato S, Takahashi S, Kimura H, Totoki Y, Shibata T, Naito M, Kim HJ, Miyata K, Kataoka K, Kondo Y.
Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment.
Nat Commun 7:13616-, 2016. DOI:10.1038/ncomms13616
Horigane S*, Ageta-Ishihara N*(*共同筆頭著者), Kamijo S, Fujii H, Okamura M, Kinoshita M, Takemoto-Kimura S, Bito H.
Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKI pathway during neuronal polarization.
Molecular brain 9(1):8, 2016. DOI:10.1186/s13041-016-0189-3
Ide S, Takahashi T, Takamatsu Y, Uhl GR, Niki H, Sora I, Ikeda K.
Distinct Roles of Opioid and Dopamine Systems in Lateral Hypothalamic Intracranial Self-Stimulation.
Int J Neuropsychopharmacol. 20(5):403-409, 2017. DOI:10.1093/ijnp/pyw113
Wu MK, Takemoto M, Taniguchi M, Takumi T, Okazaki T, Song W-J.
Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1.
American Journal of Physiology-Cell Physiology 311(1):C15-23, 2016. DOI:10.1152/ajpcell.00272.2015
Tetsuhisa Otani, Yosuke Ogura, Kazuyo Misaki, Takuya Maeda, Akiyo Kimpara, Shigenobu Yonemura, Shigeo Hayashi
IKKε inhibits PKC to promote Fascin-dependent actin bundling.
Development 143:3806-3816, 2016. DOI:10.1242/dev.138495
Yoshinori Asano, Tatsuya Kawase, Atsushi Okabe, Shuichi Tsutsumi, Hitoshi Ichikawa, Satoko Tatebe, Issay Kitabayashi, Fumio Tashiro, Hideo Namiki, Tadashi Kondo, Kentaro Semba, Hiroyuki Aburatani, Yoichi Taya, Hitoshi Nakagama and Rieko Ohki
IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.
Sci. Rep. 6:19174, 2016. DOI:10.1038/srep19174
Fujieda Y., Amengual O., Matsumoto M., Kuroki K., Takahashi H., Kono M., Kurita T., Otomo K., Kato M., Oku K., Bohgaki T., Horita T., Yasuda S., Maenaka K., Hatakeyama S., Nakayama KI., Atsumi T.
Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.
Rheumatology 55:1117-26, 2016. DOI:10.1093/rheumatology/kew005
Nita A., Nishiyama M., Muto Y., Nakayama KI.
FBXL12 regulates T cell differentiation in a cell-autonomous manner.
Genes Cells 5:517-24, 2016. DOI:10.1111/gtc.12360
Tanaka M., Shiota M., Nakao T., Uemura R., Nishi S., Ohkawa Y., Matsumoto M., Yamaguchi M., Osada-Oka M., Inagaki A., Takahashi K., Nakayama KI., Gi M., Izumi Y., Miura K., Iwao H.
Identification of low-abundance proteins in serum via the isolation of HSP72 complexes.
J Proteomics 136:214-21, 2016. DOI:10.1016/j.jprot.2016.01.008
Hosokawa H., Tanaka T., Endo Y., Kato M., Shinoda K., Suzuki A., Motohashi S., Matsumoto M., Nakayama KI., Nakayama T.
Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.
Nature Commun. 7:11289, 2016. DOI:10.1038/ncomms11289
Takeishi S., Nakayama KI.
To wake up cancer stem cells, or to let them sleep, that is the question.
Cancer Sci. 107:875-81, 2016. DOI:10.1111/cas.12958
Duquesnes N., Callot C., Jeannot P., Daburon V., Nakayama KI., Manenti S., Davy A., Besson A.
p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith–Wiedemann syndrome.
J Pathol. 239:250-61, 2016. DOI:10.1002/path.4721
Kitade S., Onoyama I., Kobayashi H., Yagi H., Yoshida S., Kato M., Tsunematsu R., Asanoma K., Sonoda K., Wake N., Hata K., Nakayama KI., Kato K.
FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors.
Cancer Sci. 107:1399-405, 2016. DOI:10.1111/cas.13026
Katayama Y., Nishiyama M., Shoji H., Ohkawa Y., Kawamura A., Sato T., Suyama M., Takumi T., Miyakawa T., Nakayama KI.
CHD8 haploinsufficiency results in autistic-like phenotypes in mice.
Nature 537:675-9, 2016. DOI:10.1038/nature19357
Hatano A, Matsumoto M, Nakayama KI.
Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling.
Genes Cells 21:1095-112, 2016. DOI:10.1111/gtc.12406
Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S.
The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.
J Mol Cell Cardiol. 100:43-53, 2016. DOI:10.1016/j.yjmcc.2016.09.013
Kayama K., Watanabe S., Takafuji T., Tsuji T., Hironaka K., Matsumoto M., Nakayama KI., Enari M., Kohno T., Shiraishi K., Kiyono T., Yoshida K., Sugimoto N., Fujita M.
GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
EMBO Rep. 18:123-37, 2017. DOI:10.15252/embr.201642444
Matsumoto M., Matsuzaki F., Oshikawa K., Goshima N., Mori M., Kawamura Y., Ogawa K., Fukuda E., Nakatsumi H., Natsume T., Fukui K., Horimoto K., Nagashima T., Funayama R., Nakayama K. & Nakayama KI.
A large-scale targeted proteomics assay resource based on an in vitro human proteome.
Nature Methods 14:251-8, 2017. DOI:10.1038/nmeth.4116
Matsumoto A., Pasut A., Matsumoto M., Yamashita R., Fung J., Saghatelian A., Nakayama KI., Clohessy JG., Monteleone E., Pandolfi PP.
mTORC1 and muscle regeneration are regulated by the LINC00961 encoded SPAR polypeptide.
Nature 541:228-32, 2017. DOI:10.1038/nature21034
Ohnishi T., Shirane M., Nakayama KI.
SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth.
Sci. Rep. 7:41130, 2017. DOI:10.1038/srep41130
Yamauchi T., Nishiyama M., Moroishi T., Kawamura A., Nakayama KI.
FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem-progenitor cells.
Mol. Cell. Biol. 37:e00470-16, 2017. DOI:10.1128/MCB.00470-16
渡邉貴樹, 上阪直史, 狩野方伸
生後発達期の小脳におけるシナプス刈り込みのメカニズム.
生化学 88(5):621-629, 2016. DOI:10.14952/SEIKAGAKU.2016.880621
Hoque MR, Ishizuka T, Inoue K, Abe-Yoshizumi R, Igarashi H, Mishima T, Kandori H, Yawo H.
A Chimera Na+-Pump Rhodopsin as an Effective Optogenetic Silencer.
PLoS One. 11(11):e0166820, 2016. DOI:10.1371/journal.pone.0166820
Zamani A, Sakuragi S, Ishizuka T, Yawo H.
Kinetic characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization.
Biophys Physicobiol. 14:13-22, 2017. DOI:10.2142/biophysico.14.0_13
Ohta H, Kohno Y, Arake M, Tamura R, Yukawa S, Sato Y, Morimoto Y, Nishida Y, Yawo H.
Adrenergic receptor-mediated modulation of striatal firing patterns.
Neurosci Res. 112:47-56, 2016. DOI:10.1016/j.neures.2016.05.004
Lee W, Kim D, Rivnay J, Matsuhisa N, Lonjaret T, Yokota T, Yawo H, Sekino M, Malliaras GG, Someya T.
Integration of Organic Electrochemical and Field-Effect Transistors for Ultraflexible, High Temporal Resolution Electrophysiology Arrays.
Adv Mater. 28(44):9722-9728, 2016. DOI:10.1002/adma.201602237
Umeda K, Ishizuka T, Yawo H, Shoji W.
Position- and quantity-dependent responses in zebrafish turning behavior.
Sci. Rep 6:27888, 2016. DOI:10.1038/srep27888
Igarashi H, Koizumi K, Kaneko R, Ikeda K, Egawa R, Yanagawa Y, Muramatsu S, Onimaru H, Ishizuka T, Yawo H.
A Novel Reporter Rat Strain That Conditionally Expresses the Bright Red Fluorescent Protein tdTomato.
PLoS One. 11(5):e0155687, 2016. DOI:10.1371/journal.pone.0155687
T. Fukuda, T. Katae, I. Harada, M. Iwao
Synthesis of Lamellarins via Regioselective Assembly of 1,2-Diarylated [1]Benzopyrano[3,4-b]pyrrol-4(3H)-one Core.
Heterocycles 95 (2):950-971, 2017. DOI:10.3987/COM-16-S(S)63
Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C, Hirao A.
Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance.
J Biol Chem. 291:21496-21509, 2016. DOI:10.1074/jbc.M116.734756
Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, Mukaida N.
MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.
Blood 127:2607-2617, 2016. DOI:10.1182/blood-2015-10-673087
Inoue, D., Nishimura, K., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K-I. and Kitamura, T
Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.
Experimental Hematology 44:172 -176, 2016. DOI:10.1016/j.exphem.2015.11.011
Kitamura, T., Watanabe-Okochi, N., Enomoto, Y., Nakahara, F., Oki, T., Komeno, Y., Kato, N., Doki, N., Uchida, T., Kagiyama, Y., Togami, K., Kawabata, K.C., Nishimura, K., Hayashi, Y., Nagase, R., Saika, M., Fukushima, T., Asada, S., Fujino, T., Izawa, Y., Horikawa, S., Fukuyama, T., Tanaka, Y., Ono, R., Goyama, S., Nosaka, T., Kitaura, J., and Inoue D.
Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).
J Biol Chem. 159:17-25, 2016. DOI:10.1093/jb/mvv114
Naganuma T, Takagi S, Kanetake T, Kitamura T, Hattori S, Miyakawa T, Sassa T, Kihara A
Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
J Biol Chem. 291(22):11676-11688, 2016. DOI:10.1074/jbc.M116.714030
Kanetake T, Sassa T, Nojiri K, Sawai M, Hattori S, Miyakawa T, Kitamura T, Kihara A
Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide.
FASEB Journal in press, 2019.
Adachi T, Hayashi T
Evolutionarily conserved phosphorylation and palmitoylation-dependent regulation of dopamine D1-like receptors in vertebrates.
Neurotransmitter 3:e1434, 2016. DOI:10.14800/nt.1434
Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y
Large-scale analysis reveals populational contributions of cortical spike rate and synchrony to behavioral functions.
J. Pathol. 595(1):385-413, 2017. DOI:10.1113/JP272794
Saiki A, Sakai Y, Fukabori R, Soma S, Yoshida J, Kawabata M, Yawo H, Kobayashi K, Kimura M, Isomura Y
In Vivo Spiking Dynamics of Intra- and Extratelencephalic Projection Neurons in Rat Motor Cortex.
Cerebral Cortex 28(3):1024-1038, 2017. DOI:10.1093/cercor/bhx012
Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A.
The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.
J Exp Med 213(8):1459-1477, 2016. DOI:10.1084/jem.20151121
Kanda M, Nagai T, Takahashi T, Liu ML, Kondou N, Naito AT, Akazawa H, Sashida G, Iwama A, Komuro I, Kobayashi Y.
Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction.
PLoS One. 11(5):e0156562., 2016. DOI:10.1371/journal.pone.0156562
Etsu Tashiro, Shizuka, Henmi, Hiroyuki Odake, Seitaro Ino, Masaya Imoto
Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation.
Biochem Biophys Res Commun. 477:801-806, 2016. DOI:10.1016/j.bbrc.2016.06.138
Kuribayashi H, Tsuhako A, Kikuchi M, Yoshida N, Koso H, Watanabe S
Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina.
Exp. Eye Res. 152:34-42, 2016. DOI:10.1016/j.exer.2016.09.005
Koso H, Tsuhako A, Lai CY, Baba Y, Otsu M, Ueno K, Nagasaki M, Suzuki Y, Watanabe
Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina.
Glia 64(11):2005-2024, 2016. DOI:10.1002/glia.23038
Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T and Sumiko Watanabe S
Identification of RNA-binding protein LARP4B as a tumor suppressor in glioma.
Cancer Res. 76(8):2254-2264, 2016. DOI:10.1158/0008-5472.CAN-15-2308
Honda A, Ito Y, Takahashi-Niki K, Matsushita N, Nozumi M, Tabata H, Takeuchi K, *Igarashi M
Extracellular signals induce glycoprotein M6a clustering of lipid rafts and associated signaling molecules.
J Neurosci 37:4046-4064, 2017. DOI:10.1523/JNEUROSCI.3319-16.2017
Nomir AG., Takeuchi Y. et al.
Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1-Cre mice.
Genesis 54(7):379-388, 2016. DOI:10.1002/dvg.22951
Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A and Hikida T.
Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage.
Learning and Memory 23 (7):359-64, 2016. DOI:10.1101/lm.042507.116
Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T.
Dopamine D2L receptor is required for visual discrimination learning.
Molecular Neuropsychiatry 2 (3):124-132, 2016. DOI:10.1159/000447970
Maekawa T, Sasaoka T, Azuma S, Ichikawa T, Melrose HL, Farrer MJ, Obata F;
Leucine-rich repeat kinase 2 (LRRK2) regulates alpha-synuclein clearance in microglia.
BMC Neuroscience 17 (1):77, 2016. DOI:10.1186/s12868-016-0315-2
Habisov, S., Huber, J., Ichimura, Y., Akutsu, M., Rogova, N., Loehr, F., McEwan, D.G., Johansen, T., Dikic, I., Doetsch, V., Komatsu, M., Rogov, V.V., *Kirkin, V.
Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.
J Biol Chem. 291:9025-9041, 2016. DOI:10.100xxx2/ejoc.201601023
Yang H, Ni HM, Guo F, Ding Y, Shi YH, Lahiri P, Fröhlich LF, Rülicke T, Smole C, Schmidt VC, Zatloukal K, Cui Y, Komatsu M, Fan J, Ding WX.
Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice.
J Biol Chem. 291:18663-18674, 2016. DOI:10.1074/jbc.M116.739821
Saito, T., Waguri, S (38人中34番目)., *Komatsu, M (38人中38番目).
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.
Nat Commun 7, 2016. DOI:10.1038/ncomms12030
Muona, M., *Lehesjoki, AE., *Komatsu, M (28人中28番目).
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.
Am. J. Hum. Genet 99:683-694, 2016. DOI:10.1016/j.ajhg.2016.06.020
Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A.
Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.
Elife 5, 2016. DOI:10.7554/eLife.14810
Lee DH, Han DH, Nam KT, Park JS, Kim SH, Lee M, Kim G, Min BS, Cha BS, Lee YS, Sung SH, Jeong H, Ji HW, Lee MJ, Lee JS, Lee HY, Chun Y, Kim J, Komatsu M, Lee YH, Bae SH.
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
Free Radic Biol Med. 99:520-532, 2016. DOI:10.1016/j.freeradbiomed.2016.09.009
Ye X, Zhou Q, Matsumoto Y, Moriyama M, Kageyama S, Komatsu M, Satoh S, Tsuchida M, Saijo Y.
Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma.
Anticancer Res. 36:6021-6029, 2016.
*Ueno T, *Komatsu M.
Autophagy in the liver: functions in health and disease.
Nat Rev Gastroenterol Hepatol. 14:170-184, 2017. DOI:10.1038/nrgastro.2016.185
Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, *Komatsu M.
A novel approach to assess the ubiquitin-fold modifier 1-system in cells.
FEBS Lett. 591:196-204, 2017. DOI:10.1002/1873-3468.12518
小川宏人
昆虫の短中距離ナビゲーションを支える神経基盤.
日本ロボット学会誌 34:685-689, 2016. DOI:10.7210/jrsj.34.685
Kimiko Shimizu, Yodai Kobayashi, Erika Nakatsuji, Maya Yamazaki, Shigeki Shimba, Kenji Sakimura & Yoshitaka Fukada
SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory.
Nature Commun. 7:12926, 2016. DOI:10.1038/ncomms12926
Jun J. Nakano, Kimiko Shimizu, Shigeki Shimba & Yoshitaka Fukada
SCOP/PHLPP1β in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior.
Sci. Rep. 6:33500, 2016. DOI:10.1038/srep33500
Jayapal SR, Ang HY, Wang CQ, Bisteau X, Caldez MJ, Xuan GX, Yu W, Tergaonkar V, Osato M, Lim B, Kaldis P.
Cyclin A2 regulates erythrocyte morphology and numbers.
Cell Cycle 15(22):3070-3081, 2016. DOI:10.1053/j.gastro.2016.09.018
Chin DW, Sakurai M, Nah GS, Du L, Jacob B, Yokomizo T, Matsumura T, Suda T, Huang G, Fu XY, Ito Y, Nakajima H, Osato M.
RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.
Blood Cancer J. 6:e379, 2016. DOI:10.1038/bcj.2015.105
Iizuka K, Yokomizo T, Watanabe N, Tanaka Y, Osato M, Takaku T, Komatsu N.
Lack of Phenotypical and Morphological Evidences of Endothelial to Hematopoietic Transition in the Murine Embryonic Head during Hematopoietic Stem Cell Emergence.
PLoS One. 11(5):e0156427, 2016. DOI:0.1371/journal.pone.0156427
Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y.
Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice.
Gastroenterology 152(1):218-231.e14, 2017. DOI:10.1053/j.gastro.2016.09.018
Sakuma I, Higuchi S, Fujimoto M, Takiguchi T, Nakayama A, Tamura A, Kohno T, Komai E, Shiga A, Nagano H, Hashimoto N, Suzuki S, Mayama T, Koide H, Ono K, Sasano H, Tatsuno I, Yokote K, Tanaka T.
Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop.
J Clin Endocrinol Metab 101(3):841-6, 2017. DOI:10.1210/jc.2015-2855
Hengguang Zhao, Rieger S, Abe K, Hewison M, Lisse T.
DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization.
Int. J. Mol. Sci. 17:1984, 2016. DOI:10.3390/ijms17121984
Hadano S, Mitsui S, Pan L, Otomo A, Kubo M, Sato K, Ono S, Onodera W, Abe K, Chen X, Koike M, Uchiyama Y, Aoki M, Warabi E, Yamamoto M, Ishii T, Yanagawa T, Shang H-F, Yoshii F.
Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.
Human Molecular Genetics 25:25, 2016. DOI:10.1093/hmg/ddw180
Motojima M, Tanimoto S, Ohtsuka M, Matsusaka T, Kume T, Abe K
Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2.
Cells Tissues Organs 201:380-389, 2016. DOI:10.1159/000445027
Motojima M, Ogiwara S, Matsusaka T, Kim SY, Sagawa N, Abe K, Ohtsuka M.
Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system.
Mammalian genoem 27:62-69, 2016. DOI:10.1007/s00335-015-9610-y
Fuchs H, Sabrautzki S, Przemeck G, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, Östereicher M, Hans W, Abe K et al.
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.
G3・Genes| Genomes| Genetics 6:4035-4046, 2016. DOI:10.1534/g3.116.033670
Nakamura, Y., Yanagawa, Y., Morrison, S.F., Nakamura, K.
Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication.
Cell Metabolism 25:322–334, 2017. DOI:10.1016/j.cmet.2016.12.002
Matsunaga R, Nishino T, Yokoyama A, Nakashima A, Kikkawa U, Konishi H.
Versatile function of the circadian protein CIPC as a regulator of Erk activation.
Biochem Biophys Res Commun. :377-383, 2016. DOI:10.1016/j.bbrc.2015.11.117
Nishino T, Matsunaga R, Jikihara H, Uchida M, Maeda A, Qi G, Abe T, Kiyonari H, Tashiro S, Inagaki-Ohara K, Shimamoto F, Konishi H.
Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.
Biochim Biophys Acta. 1861:1816-1827, 2016. DOI:10.1016/j.bbalip.2016.09.006
Ayumi Hashimoto, Toyohiro Sawada, Itsuki Kageyama, Kiyohisa Natsume
Activation of the muscarinic receptors induces the transition of the epileptic discharges to beta oscillation in hippocampal slices.
Biophysics_and Physicobiology 14:137-146, 2017. DOI:10.2142/biophysico.14.0_137
Watabe, A.M., Nagase, M., Hagiwara, A., Hida, Y., Tsuji, M., Ochiai, T., Kato, F., Ohtsuka, T.
SAD-B Kinase regulates presynaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory.
Journal of Neurochemistry 136(1):36-47, 2016. DOI:10.1111/jnc.13379
Tsuji, M., Takahashi, Y., Watabe, A.M., Kato, F.
Enhanced long-term potentiation in mature rats with a history of cryptogenic infantile spasms.
Epilepsia 57(3):495-505, 2016. DOI:10.1111/epi.13315
Sugimura, Y.K., Takahashi, Y., Watabe, A.M., Kato, F.
Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala.
Journal of Neurophysiology 115:2721-2739, 2016. DOI:10.1152/jn.00946.2015
Nomoto, M., Ohkawa, N., Nishizono, H., Yokose, J., Suzuki, A., Matuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A.M., Kato, F., Inokuchi, K.
Cellular tagging as a neural network mechanism for behavioral tagging.
Nature Communications 7(12319):1-11, 2016. DOI:10.1038/ncomms12319
Takamura, S., Yagi, H., Hakata, Y., Motozono, C., McMaster, SR., Masumoto, T., Fujisawa, M., Chikaishi, T., Komeda, J., Itoh, J., Umemura, M., Kyusai, A., Tomura, M., Nakayama, T., Woodland, DL., Kohlmeier, JE., Miyazawa, M.
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
J Exp Med. 213(13):3057-3073, 2016. DOI:10.1084/jem.20160938
Tuboly E, Futakuchi M, Varga G, Erces D, Tokes T, Meszaros A, Kaszaki J, Suzui M, Imai M, Okada A, Okada N, Boros M, Okada H
C5a inhibitor protects ischemia/reperfusion injury in rat small intestine.
Microbiol Immunol 60（1）:35-46, 2016. DOI:10.1111/1348-0421
Futakuchi M, Fukamachi K, Suzui M
Heterogeneity of tumor cells in the bone microenvironment: mechanisms and therapeutic targets for bone metastasis of prostate or breast cancer.
Adv Drug Deliv Rev 99, 2016. DOI:10.1016/j.addr.2015.11.017
Suzui M, Futakuchi M, Fukamachi K, Numano T, Abd Elgied M, Takahashi S, Ohnishi M, Omori T, Tsuruoka S, Hirose A, Kanno J, Sakamoto Y, Alexander DB, Xu J, Tsuda H
Multiwalled carbon nanotubes intratracheally instilletd into the rat lung induce development of pleural malignant mesothelioma and lung tumors.
Cancer Sci 107（7）:924-935, 2016. DOI:10.1111/cas.12954
Escudero-Esparza A., Bartoschek M., Gialeli C., Okroj M., Owen S., Jirström K., Orimo A., Jiang WG., Pietras K., Blom AM.
Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer.
Oncotarget 7:76920-76933, 2016. DOI:10.18632/oncotarget.12729
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The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas.
Cell Tissue Res 365:675-89, 2016. DOI:10.1007/s00441-016-2471-1
Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirström K, Pietras K, Blom AM.
Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer.
Oncogene. 235:5585-5596, 2016. DOI:10.1038/onc.2016.98
Okada M, Mei ZW, Hossain MI, Tominaga T, Takebayashi T, Murakami M, Yasuda M, Shigehiro T, Kasai T, Mizutani A, Murakami H, El Sayed Iel T, Dan S, Yamori T, Seno M, Inokuchi T.
Synthesis and in vitro cancer cell growth inhibition evaluation of 11-amino-modified 5-Me-indolo[2,3-b]quinolines and their COMPARE analyses.
Med Chem Res 25(5):879-892, 2016. DOI:10.1007/s00044-016-1508-z
Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H.
Proteomic profiling reveals that collismycin A is an iron chelator.
Sci Rep 6:38385, 2016. DOI:10.1038/srep38385
Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H.
Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.
Sci Rep 6:26521, 2016. DOI:10.1038/srep26521
Muroi M, Futamura Y, Osada H.
Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase.
Nat Prod Rep 33:621-625, 2016. DOI:10.1039/c5np00106d
Nakamura T, Ma Y, Iida K, Ohtake T, Seimiya H, Nagasawa K.
Design, Synthesis and Evaluation of an L-Dopa-Derived Macrocyclic Hexaoxazole (6otd) as a G-Quadruplex-Selective Ligand.
Heterocycles 92:305-315, 2016. DOI:10.3987/COM-15-13383
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Total Synthesis of the Depsipeptide FR901375 and Preliminary Evaluation of Its Biological Activity.
European Journal of Organic Chemistry 34:5667-5677, 2016. DOI:10.1002/ejoc.201601023
Narita K, Matsuhara K, Itoh J, Akiyama Y, Dan S, Yamori T, Ito A, Yoshida M, Katoh T.
Synthesis and biological evaluation of novel FK228 analogues as potential isoform selective HDAC inhibitors.
Eur J Med Chem 121:592-609, 2016. DOI:10.1016/j.ejmech.2016.05.031
Lou C, Yokoyama S, Abdelhamed S, Saiki I, Hayakawa Y.
Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells.
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Uesugi S, Fujisawa N, Yoshida J, Watanabe M, Dan S, Yamori T, Shiono Y, Kimura K.
Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition.
J Antibiot (Tokyo) 69(3):133-140, 2016. DOI:10.1038/ja.2015.103
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NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in oral squamous cell carcinoma.
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Sasahira T, Nishiguchi Y, Fujiwara R, Kurihara M, Kirita T, Bosserhoff AK, Kuniyasu H.
Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression.
Oncotarget 7:26754-26764, 2016. DOI:10.18632/oncotarget.8495
Kubo H, Shimono R*,Nakamura S, Koyano K,Jinnai W, Yamato S, Yasuda S, Nakamura M, Tanaka A, Fujii T, Kanenishi K, Chiba Y, Miki T, Kusaka T, Ueno M.
Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets.
Neonatology 111(3):203-10, 2016. DOI:10.1159/000450721
Saito M, Okumura K, Yoshizawa Y, Munakata H, Isogai E, and Wakabayashi Y.
Meis1 is required for c-Met inhibition to suppress cell proliferation of skin squamous cell carcinoma cells.
Journal of Biosciences and medicines 4(1):53-65, 2016. DOI:10.4236/jbm.2016.47007

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